Pathway Figures deposited at NDEx

Browse the subset of pathway figures below that have been coverted to the Cytoscape CX format and deposited at NDEx.

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• Superimposing mTOR signaling subgraphs from KEGG and WikiPathways (2019, Homo sapiens,unidentified)
• By KEGG pathway enrichment analysis, ANXA2 upregulated filopodia pathway, resulting in cell metastasis (2019, NA)
• HER4-JAK2-STAT5 pathway modeled in this paper (2019, Homo sapiens,Mus musculus)
• Circadian rhythm pathway identified as one of the significant pathways by the IPA (2019, NA)
• The DA-induced ascorbate release signaling pathway in the retina (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Gallus gallus,Xenopus laevis,Homo sapiens,Diaporthe sclerotioides)
• Mechanism of PDCoV N protein interfered with the type I IFN response (2019, Influenza A virus,Coronaviridae,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Vesicular stomatitis virus,West Nile virus,Murine hepatitis virus,Porcine epidemic diarrhea virus,SARS coronavirus NS-1,Transmissible gastroenteritis virus,Porcine deltacoronavirus,Porcine rotavirus,Bos taurus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Mus musculus,Gallus gallus,Renilla reniformis,NA)
• A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence (2019, Zea mays,Glycine max,Triticum aestivum,Malus domestica,Camellia sinensis,Fragaria x ananassa,Theobroma cacao,Punica granatum,Vicia faba,Prunus domestica,Prunus dulcis,Picea abies,Vaccinium myrtillus,Rubus idaeus,Pistacia vera,Carya illinoinensis,Vaccinium angustifolium,Annona squamosa,Arbutus unedo,Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus,Opsanus beta)
• Variants of the Notch-Wnt crosstalk (2019, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis)
• Canonical Notch signaling pathway (2019, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis)
• Canonical Wnt signaling pathway (2019, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis)
• CXCR7-EGFR crosstalk and its effect on the MAPK signaling pathway (2019, NA)
• Novel Insights of Lymphomagenesis of Helicobacter pylori-Dependent Gastric Mucosa-Associated Lymphoid Tissue Lymphoma (2019, NA)
• Targeting the Hedgehog pathway (2019, NA)
• Hedgehog pathway in absence (a) and in presence (b) of HH ligand (2019, NA)
• Therapeutic targeting of oncogenic HH/GLI signaling in cancer cells resistant to SMOi (2019, NA)
• Genetic and molecular mechanisms conferring resistance to SMO inhibitors (2019, NA)
• Canonical SMO-dependent HH/GLI signaling (2019, NA)
• The MAPK pathway in melanoma (2019, NA)
• Attenuation of insulin signaling pathway in insulin resistance condition (2019, NA)
• Insulin signaling pathway under physiological condition (2019, NA)
• Proposed model for ANXA2 regulation of AKT activation (2019, NA)
• Schematic diagram explaining how TRPC3 acts as an anti-apoptotic regulator via RASA4-MAPK pathway in MDA-MB-231 (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Schematic drawing showing proposed mechanisms of action of Curcuma longa (curcumin) (2019, NA)
• Estradiol action (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Equus caballus,vectors)
• Metabolomic analysis of in vitro effects of OPC-163493 in HepG2 cells (2019, NA)
• VPA induces apoptosis and inhibits IL-4 production in TGD lymphocytes (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• Impaired ribosome biogenesis (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Thermochaetoides thermophila,Homo sapiens)
• Proposed molecular mechanism of the anti-esophageal cancer activity of Rk3 (2019, Panax ginseng,Panax notoginseng,Homo sapiens,Mus musculus,Bos taurus)
• CLIP‐170 controlling Met RTK recycling in migrating cells (2019, Armoracia rusticana,Diaporthe sclerotioides,Broussonetia kazinoki,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• VPA impacts the B cell differentiation into plasma cells and in the isotype switch and maturation affinity of immunoglobulins (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach (2019, Homo sapiens,Sequoia sempervirens)
• Aberrant BCR signaling in GC‐derived B‐cell lymphomas (2019, NA)
• Metabolic dysregulation in GC‐derived B‐cell lymphoma (2019, NA)
• VPA promotes the generation of Treg cells (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• Schematic indicating the pathway from Micronucleus formation to activation of the cGAS-STING pathway, and canonical and non-canonical routes to Type I interferon response (2019, NA)
• STAT3 signaling pathway in cancer cells (2019, Ganoderma lucidum,Inula helenium,Eupatorium lindleyanum,Rhus coriaria,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease (2019, NA)
• Schematic diagram of ROS-medicate HIF-1 signaling pathway (2019, Oryctolagus cuniculus,Armoracia rusticana,Canis lupus familiaris,Capra hircus,Malus domestica,Sesamum indicum,Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Metabolic pathway of amino acid glutamate (a) and expression changes of related genes (b) (2019, NA)
• Schematic drawing presents the detail signaling pathways of endometrial carcinogenesis (2019, NA)
• ABT cell receptor (TCR) signaling pathway (2019, NA)
• Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach (2019, Homo sapiens,Sequoia sempervirens)
• Pathway representing T cell signaling (2019, Saccharomyces cerevisiae,Nicotiana tabacum,Diaporthe sclerotioides,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Bos taurus)
• Schematic drawing of the details of the signaling pathways of five major cardiomyopathies (2019, NA)
• Analysis of the PI3K/AKT signaling pathway based on the KEGG database (2019, NA)
• VPA inhibits LPS signaling in macrophages (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach (2019, Homo sapiens,Sequoia sempervirens)
• Representation of the genes in glycolysis, pentose phosphate pathway, and the TCA cycle (2019, Corynebacterium glutamicum)
• Core molecular mechanism of non-apoptotic regulated cell death (2019, Escherichia coli,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Chlamydia trachomatis,Francisella tularensis,Brucella abortus,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Vaccinia virus,Cowpox virus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Sus scrofa)
• Model suggesting the relationships between Th17, Th1* and cTh1 populations and their potential roles in post-vaccination immunity, LTBI and active TB (2019, Homo sapiens,Mycobacterium tuberculosis,Macaca mulatta,Mycobacterium tuberculosis variant bovis BCG,Macaca fascicularis,Mycobacterium tuberculosis variant bovis,Mus musculus,Bos taurus,Human immunodeficiency virus 1)
• Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Prosopis affinis,Homo sapiens)
• Differential network for the pathway “Signaling by NOTCH1” in the lateral compartment (2019, Homo sapiens,Mus musculus,Danio rerio,Listeria monocytogenes,Canis lupus dingo)
• Flip-Flopping Retinal in Microbial Rhodopsins as a Template for a Farnesyl/Prenyl Flip-Flop Model in Eukaryote GPCRs (2019, Caenorhabditis elegans,Helicoverpa armigera,Rhodnius prolixus,Ecdysozoa,Saccharomyces cerevisiae,Chlamydomonas reinhardtii,Opisthokonta,Homo sapiens,Bos taurus,Halobacterium salinarum)
• Extrinsic and intrinsic apoptosis (2019, Escherichia coli,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Chlamydia trachomatis,Francisella tularensis,Brucella abortus,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Vaccinia virus,Cowpox virus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Sus scrofa)
• MicroRNA-regulated networks in muscle wasting during cancer cachexia based on meta-analysis data (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Solanum aethiopicum)
• Key metabolic gene sets are differentially regulated in subcutaneous adipose tissue after 36 h fasting vs control study (horizontally) and in LBW vs NBW men (vertically) (2019, Homo sapiens,Mus musculus)
• Differential gene expression involved in the KEGG pathway regulated by TRF treatment, i.e., (a) cell cycle, (b) p53 signalling pathway, (c) FoxO signalling pathway, (d) Wnt signalling pathway, and (e) ErbB signalling pathway (2019, NA)
• Protein–protein interaction (PPI) network in muscle wasting in cancer cachexia (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Solanum aethiopicum)
• Mechanisms contributing to regulation of tumor clearance by effector cells (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human papillomavirus,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,NA)
• Signaling pathway of apoptosis (2019, NA)
• Negative regulation of the TRAIL-driven pathway (2019, Panax ginseng,Tripterygium wilfordii,Garcinia mangostana,Andrographis paniculata,Lithospermum erythrorhizon,Pinus koraiensis,Homo sapiens,Mandrillus leucophaeus,Mus musculus)
• TRAIL (TNF-related apoptosis-inducing ligand)-mediated signaling (2019, Panax ginseng,Tripterygium wilfordii,Garcinia mangostana,Andrographis paniculata,Lithospermum erythrorhizon,Pinus koraiensis,Homo sapiens,Mandrillus leucophaeus,Mus musculus)
• Main signaling pathways activated by growth factor signaling through receptor tyrosine kinases (RTK) and the importance of Mg2+ (2019, NA)
• Network analysis of proteome datasets in M2 polarized (vs (2019, Respiratory syncytial virus,Human gammaherpesvirus 8,Murid gammaherpesvirus 4,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis variant bovis BCG,Trypanosoma cruzi,NA)
• Network analysis of proteome datasets in M1 polarized (vs (2019, Respiratory syncytial virus,Human gammaherpesvirus 8,Murid gammaherpesvirus 4,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis variant bovis BCG,Trypanosoma cruzi,NA)
• Bone morphogenetic protein (BMP) signaling pathway and inhibition by Noggin (2019, NA)
• Schematic detailing the relationship among CaMKII-, BDNF-, and NMDAR-inducing LTP and morphine tolerance (2019, NA)
• Hypothetical model for the role of thrombomodulin (TM) in mitogen-activated protein kinases (MAPKs) signaling: Thrombomodulin regulates the activation of MAPKs under various pathophysiological conditions (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Klebsiella pneumoniae,Antarctothoa delta)
• Molecular genetic pathways in long-term epilepsy-associated tumors (LEATs) and pediatric type diffuse low-grade glioma (DLGG) (2019, NA)
• Upstream and downstream of mTORC1 and mTORC2 (2019, NA)
• mTORC1 and mTORC2 (2019, NA)
• Reelin signaling pathway in Golgi Dynamics and morphology (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Interconnection of the pathways studied, the genes in which we have measured expression and connection to mitochondrial respiration (2019, NA)
• Cellular pathways and major players for the induction of the immediate early genes egr (a) and c-jun (b), and downstream targets, with focus on pathways previously linked to learning and memory in honey bees [, , , ] (2019, NA)
• Irradiation-induced retraction and death of endothelial cells (2019, NA)
• Expression of the NCRs and their Ligands (2019, Homo sapiens)
• Diagrammatic model summarising the proposed bimodal Wnt signalling regulation by DYRK1A, as reported in Figs – (2019, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Matthiola incana,Equus asinus,Iris germanica,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Human immunodeficiency virus 1)
• Brief summary of the possible mechanisms of KSHV-mediated pathogenesis at the cellular level (2019, NA)
• Acorus calamus (asarone) for cancer chemoprevention (2019, Acorus calamus,Homo sapiens)
• Possible site of action of beta (B) asarone in apoptosis, cell proliferation and growth (2019, Acorus calamus,Homo sapiens)
• Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers (2019, NA)
• Schematic diagram for the inhibitory mechanism of CYC116 in mast cell activation (2019, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Flavonoids on the expression of MMP and ADAMTS in osteoarthritis (2019, Streptococcus pneumoniae,Escherichia coli O157H7,Mycoplasmoides pneumoniae,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Human gammaherpesvirus 8)
• PIN1and PTOV1 pathway interactions (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells (2019, NA)
• Fatty livers demonstrate a premalignant signature (2019, NA)
• At the intersection of DNA damage and immune responses (2019, Homo sapiens,Mus musculus,Listeria monocytogenes)
• Illustration of proposed effects of the phosphoinositide 3‐kinase (PI3K) pathway inhibition on the heart in the setting of anthracycline cancer therapy (2019, Zea mays,Triticum aestivum,Homo sapiens,Mus musculus)
• T10 inhibited NFKB activity via miR155-5p/SHIP1 axis (2019, NA)
• PI3K/Akt signaling pathway (2019, Mus musculus,Homo sapiens)
• LSD1–NOTCH–ASCL1 Axis in Small Cell Lung Cancer (SCLC) (2019, NA)
• Effect of changes in ECM‐mediated signalling pathways (2019, NA)
• Flow chart of the DARPP-32-CaN pathway in the Cys311 variant of DRD2 (2019, NA)
• Conceptualized overview of the association between inflammation and angiogenesis (2019, NA)
• Protein-protein network analysis using the DE genes (log2 fold > 2 and < 2) in the transcriptomic profiles of the cows with PTB-associated lesions versus the control group (2019, Mycobacterium avium,Mycobacterium avium subsp. paratuberculosis,Homo sapiens)
• The MAPK (ERK) signaling pathway in the KEGG pathway map (hsa04010) where the main path from growth factor to ERK kinase is marked in pink (2019, metagenome,metagenomes,environmental samples,Homo sapiens,Human gammaherpesvirus 8,NA)
• Molecular biological features in the adrenal gland of Hatano rats (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries,Matthiola incana)
• Generalised mechanism of chimeric antigen receptor (CAR) signalling provided by CD3‐ζ ITAMs and a costimulator domain (2019, NA)
• NLRP3 inflammasome activation involved in OA-induced ALI rat model (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Enrichment analysis of genes transcriptionally related to morphometric similarity (2019, Homo sapiens,Rattus norvegicus)
• Diagram illustrates the mechanisms of insulin resistance (2019, Saccharomyces cerevisiae,Vitis vinifera,Ganoderma lucidum,Platycodon grandiflorus,Caulerpa lentillifera,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Equus caballus,Homo sapiens)
• The signaling pathways regulating TREM2 phagocytosis and TREM2 modulation of NFKB phosphorylation/activation (2019, NA)
• Scheme of the parietal cell of a gastric gland (2019, Homo sapiens,Rattus norvegicus)
• Immune signaling network in MS (2019, Homo sapiens)
• The phenylpropane pathway (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Solanum tuberosum,Arachis hypogaea,Magnoliopsida,Fragaria x ananassa,Nicotiana benthamiana,Eucalyptus intertexta,Ipomoea batatas,Solanum melongena,Phytophthora infestans,Brassica rapa subsp. chinensis,Solanum chilense,Lilium regale,Homo sapiens,vectors,Agrobacterium tumefaciens)
• Therapeutic targeting of glycolysis, lipid and redox metabolism in CSCs (2019, Homo sapiens)
• Synthesis, activation, secretion, and downstream actions of MGP (matrix Gla protein) (2019, NA)
• Lipotoxicity in promoting insulin resistance in skeletal muscle (2019, NA)
• AA metabolic network in human PMNs (2019, Homo sapiens,Cricetus cricetus)
• Annotated functions of the extracted pathway network (2019, NA)
• DEGs relevant to the “protein processing in endoplasmic reticulum” pathway under group “D vs (2019, NA)
• Influence of TGFB1 on the balance between the canonical WNT/Beta-catenin signaling and PPARG (2019, NA)
• Regulation of gene expression (A) and protein phosphorylation level (B) of ILP (IGF → FOXO cascade) during different diet stress (2019, NA)
• IGF-PI3K-AKT-FOXO pathway of insulin signaling (2019, NA)
• Wnt/Beta-catenin signaling pathway regulated by PARG gene silencing during BaP-induced lung cancer (2019, NA)
• The role of FcμR in central deletion and B cell repertoire selection (2019, NA)
• Summary of NAD+ metabolism (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,unidentified)
• Mechanistic pathways underlying reverse cholesterol transport from macrophages to liver (2019, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• GPCR trafficking and compartmentalized signaling (2019, NA)
• Antibody-mediated complement activation (2019, NA)
• Proposed models of CST1 participating in the signaling pathways.Notes: CST1 was involved in GSK3, AKT, and IL-6 pathways (2019, Homo sapiens)
• Gene networks and canonical pathways generated by Ingenuity Pathway Analysis (2019, NA)
• GSK-3B/Snail pathway is involved in the synergistic effect of BAY 87-2243 plus HDAC inhibitors (2019, NA)
• Transcriptome analysis results of nuclear factor erythroid-2 related factor 2 knockdown (2019, Homo sapiens)
• Role and expression of proteins identified by proteomic analysis within NAD+ metabolism and signaling pathway (2019, NA)
• Downstream signaling pathway of adiponectin (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• T helper cell differentiation pathway of MAIT cells in comparison with conventional T cells (2019, NA)
• Natural killer cell signaling pathway of MAIT cells in comparison with conventional T cells (2019, NA)
• Role of macrophage, fibroblast and endothelial cell pathways in MAIT cells (2019, NA)
• Schematic model of LOXL2 promoting lymphangiogenesis and lymph node metastasis (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• Scheme of the immune system in HCC surveillance and the metabolic effects of alcohol exposure on hepatocyte (2019, NA)
• Five functional lncRNA-mRNA trans regulatory network (2019, Homo sapiens,Mus musculus)
• Protein-Protein interaction network and 5 identified sub-networks of TTR-mRNAs (2019, Homo sapiens,Mus musculus)
• Wnt signaling with two intersecting networks: Canonical Wnt (or Beta-catenin-dependent) and non-canonical Wnt (or Beta-catenin-independent) pathways (2019, NA)
• Parallel pathway in detoxifying environmental electrophiles (2019, NA)
• Scheme of differentiation of M cells in PP (2019, NA)
• MEF-2 isoforms' (A-D) roles in development and tumorigenesis (2019, NA)
• BCR: a promiscuous fusion partner in hematopoietic disorders (2019, NA)
• Mitochondrial generation of ROS (2019, Mus musculus,Rattus norvegicus,Homo sapiens,herbal medicine)
• Interaction mapping of overlapping proteome changes in astrocytes treated with GBM a -stem and b -diff EVs (2019, NA)
• Mutation enrichment of Nectin adhesion pathway (2019, NA)
• Sprouty2—a Novel Therapeutic Target in the Nervous System? (2019, NA)
• IPA prediction networks associated with Ginsenoside Rg1 protective activity on AD mice in this study (2019, NA)
• Mitochondrial physiology (2019, Mus musculus,Rattus norvegicus,Homo sapiens,herbal medicine)
• Diagram showing differentially expressed genes in BXW-resistant and BXW-susceptible genotypes of banana after inoculation with Xanthomonas campestris pv (2019, NA)
• Pulmonary vascular responses to hypoxia with emphasis on the role of HIF isoforms in remodeling (2019, Bos taurus,Felis catus,Vicugna pacos,Bos grunniens,Lama glama,Vicugna vicugna,Bos grunniens x Bos taurus,Lama guanicoe,Mus musculus,Rattus norvegicus,Homo sapiens)
• Alpha-Synuclein and the modulation of lipid signaling (2019, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Sus scrofa,NA,NA)
• Action of MR309 to decrease the expression of inflammatory cytokines and the hyperexcitability of spinal neurons after contusion of the spinal cord (2019, NA)
• Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway network for Kashin-Beck disease (KBD)-related genes (2019, NA)
• Functional interplay of IL-21 with type I interferons in the response to MRSA (2019, Staphylococcus aureus,Homo sapiens)
• Potential role for TXNIP in HG-mediated RPE dysfunction (2019, NA)
• PID1 alters the antilipolytic action of insulin and increases lipolysis via inhibition of AKT/PKA pathway activation (2019, Rattus norvegicus,Homo sapiens)
• UV-C treatment promotes quality of early ripening apple fruit by regulating malate metabolizing genes during postharvest storage (2019, Nicotiana tabacum,Zea mays,Solanum lycopersicum,Solanum tuberosum,Malus domestica,Fragaria x ananassa,Phaseolus vulgaris,Prunus persica,Mangifera indica,Actinidia deliciosa,Citrus reticulata,Prunus avium,Cydonia oblonga,Ribes rubrum,NA)
• HSVs interfere with antiviral processes in innate immune cells (2019, Human alphaherpesvirus 1,Human alphaherpesvirus 2,Homo sapiens)
• HSV proteins modulate key steps in interferon-related pathways (2019, Human alphaherpesvirus 1,Human alphaherpesvirus 2,Homo sapiens)
• HSVs modulate antiviral mechanisms related to cell death in non-immune cells (2019, Human alphaherpesvirus 1,Human alphaherpesvirus 2,Homo sapiens)
• Prospective model for clarifying the role and regulation of ATG5 and ATG7 on autophagy and ER stress (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Squalene biosynthetic pathways and production strategies (2019, NA)
• S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• “Cytokine–cytokine receptor interaction”, “steroid biosynthesis” and “cell cycle” pathway and the identified regulator (2019, Bos taurus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Bos grunniens,Mus musculus,Rattus norvegicus,Homo sapiens,Molva molva,Staphylococcus aureus 1-B-1)
• Xylose metabolism in C (2019, Escherichia coli,Clostridium acetobutylicum,Acetivibrio thermocellus,Clostridium acetobutylicum ATCC 824,Synechococcus elongatus,Clostridium acetobutylicum DSM 1731,Diaporthe sclerotioides,Eucalyptus intertexta,Homo sapiens,Dromaius novaehollandiae)
• Herpesviral antagonist m152 reveals differential activation of STING‐dependent IRF and NF‐KB signaling and STING's dual role during MCMV infection (2019, Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Murid betaherpesvirus 1,Murid gammaherpesvirus 4,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Listeria monocytogenes,Matthiola incana,Listeria monocytogenes Italy,Homo sapiens,NA,NA)
• Protein–protein interaction networks.Notes: Upexpression genes were analyzed and constructed a network (2019, NA)
• Diagram showing the main paracrine and dichotomic autocrine functions of the IL-6/JAK/STAT3 pathway in the pathophysiology of skeletal muscle (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathogenesis of diabetic complications (2019, NA)
• Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) (2019, Danio rerio,Homo sapiens)
• Hypothesized mechanism of DS on learning and memory (2019, NA)
• Promoter hypomethylation of genes involved in myogenesis, structural dynamics of muscles and CDC42 signaling (2019, NA)
• Colorectal cancer pathway enriched in KEGG (2019, NA)
• Proposed molecular mechanism for LPS-induced downregulation of StAR expression and progesterone production in pGL (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli)
• Angiogenesis signaling pathways induced by oxidative stress (2019, Mus musculus,Rattus norvegicus,Glycine max,Allium sativum,Homo sapiens)
• Model depicting how novel drugs targeting the Y‐box binding protein‐1 (YBX1) activation pathway overcome drug resistance (2019, NA)
• Mechanisms of Annexin A1 in tumorigenesis (2019, NA)
• Annexin A1 in inflammation (2019, NA)
• Putative suppressive pathway of Pj-ME in displaying its anti-inflammatory response (2019, Protium javanicum,Homo sapiens)
• A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis (2019, NA)
• Metabolic pathway of propionyl-CoA and methylmalonyl-CoA (2019, NA)
• Proposed model of participation of SNHG1 in the regulation of signaling pathways that contribute sorafenib resistance in HCC cells (2019, NA)
• Mechanistic scheme of lncRNA lnc-TALC in GBM (2019, NA)
• Pool sizes of intracellular metabolites in S (2019, Kluyveromyces marxianus)
• Graphical summary (2019, Candida dubliniensis,Olea europaea,Helianthus annuus,Mus musculus,Cavia porcellus,Homo sapiens,Luscinia megarhynchos)
• A Developing Therapeutic Decision Tree for Ductal Breast Cancer with Emphasis on the TNBC Subtype (2019, NA)
• Endocrine and pharmacological regulation of penile erection (2019, NA)
• Comfrey’s mode of action by interference with the NFKB signaling pathway (2019, Symphytum officinale,Homo sapiens)
• Regulatory pathways leading to stem-like cells underlie prostate cancer progression (2019, Homo sapiens)
• Beta-adrenergic signaling pathway in prostatic cancer (2019, NA)
• Evolutionary conservation of the IIS pathway (2019, Saccharomyces cerevisiae,Oryza sativa,Malus domestica,Olea europaea,Curcuma longa,Agaricus bisporus,Theobroma cacao,Zingiber officinale,Punica granatum,Salvia rosmarinus,Astragalus membranaceus,Ganoderma lucidum,Withania somnifera,Aloe vera,Centella asiatica,Lentinula edodes,Erythrina poeppigiana,Rhodiola rosea,Phyllanthus emblica,Mucuna pruriens,Agaricus blazei,Ilex paraguariensis,Pterocarpus marsupium,Auricularia auricula-judae,Platanus orientalis,Homo sapiens,Macaca mulatta,Homo sapiens neanderthalensis,Drosophila melanogaster,Caenorhabditis elegans,Mus musculus,NA)
• CGAS-STING pathway in anti-tumor immunity (2019, NA)
• IFNG pathway associated with differentially expressed genes between SRHIC and WRHIC purified CD8 T cells (2019, NA)
• Comprehensive overview of the role of Clusterin on apoptosis-related events in cancer cells (2019, Mus musculus,Meriones unguiculatus,Homo sapiens,prion,Mustela lutreola)
• Schematic showing mechanisms underlying morphine tolerance (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Simian immunodeficiency virus,Phytomonas oxycareni,NA)
• Targeting of host gene expression by Toxoplasma gondii (2019, Toxoplasma gondii,Sus scrofa,Equus caballus,Felis catus,Trypanosoma cruzi,Toxoplasma gondii type I,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,NA)
• Autophagy initiates host immunity and Toxoplasma immune evasion (2019, Toxoplasma gondii,Sus scrofa,Equus caballus,Felis catus,Trypanosoma cruzi,Toxoplasma gondii type I,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,NA)
• Proposed Schematic diagram of Mda5 signaling pathway in Teleost based on a Mammalian Model (2019, NA)
• Role of the classical and terminal complement pathways in cold agglutinin disease and target levels of complement inhibitors (2019, NA)
• Graphical sketch of the expression and inhibition of different pathways (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• New mechanistic insights into modifiable risk factors that promote pancreatic cancer (2019, Mus musculus,Plasmid pTF1,Homo sapiens)
• Schematic presentation of the cytotoxic pathways, induced in cancer cells by the complement C5b-9, the counteractive cellular resistance mechanisms, and postulated approaches to overcome this cancer evasion (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Escherichia coli)
• MiR‐125b‐protein and protein‐protein interaction network of differentially expressed genes, with particular focus on AHSG (fetuin‐A), FGF‐23, and TNFRSF11B (osteoprotegerin) (2019, Homo sapiens,Caenorhabditis elegans,clinical samples)
• Schematic view of signaling events elicited by LPS in RPE cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus caballus,Equus asinus,Armoracia rusticana,Raphanus sativus,Lycium barbarum,Mus musculus,Rattus norvegicus,Homo sapiens,Klebsiella pneumoniae,Melanogrammus aeglefinus)
• Proposed mode of action for RHOA to maintain TE characteristics in the expanding blastocyst (2019, NA)
• Differential regulation and effects of glycolysis induction in GM-DCs upon stimulation over time (2019, NA)
• Cellular metabolism networks (2019, NA)
• Proposed model for the impact of Metformin on FOXO3a and gene transcription in primary human fibroblasts (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Hepatitis B virus,Bacillus anthracis)
• The regulation of CP biosynthesis and the attachment to PG in S (2019, NA)
• Functional network of cancer derived EVs in GC microenvironment (2019, NA)
• Regulatory network of ferroptosis (2019, NA)
• Illustrative diagram for exosome-mediated transfer of therapeutic resistance in the tumor microenvironment (TME) (2019, NA)
• Fibroblast growth factor receptor 4 signalling pathway in cancer (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Effects of SIRT2/cMYC pathway in CCA cells.SIRT2 and cMYC reprogrammed the metabolism of CCA cells by up-regulating downstream p-PHDA1 and PHGDH/PSAT1/PSPH (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Hepatovirus A,NA)
• DNA repair pathways with mutated genes highlighted (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Scophthalmus rhombus)
• Therapies targeting cancer specific DNA repair defects (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Scophthalmus rhombus)
• Compound-target network (2019, NA)
• Target-pathway network (2019, NA)
• Mechanism by which GBE attenuates diabetic atherosclerosis (2019, NA)
• Schematic illustration of SAA attenuating kidney oxidative stress in 5/6Nx rats (2019, NA)
• Focal forebrain IR/IGF1R DKO eliminates signaling by receptor homodimers and hybrids in hippocampus or central amygdala (2019, NA)
• Targeting NRF2 antioxidant pathway for IDH1-mutated cancers (2019, NA)
• TNFA and cAMP-PKA signal pathways exert opposite effects to regulate GD3 synthase gene expression in human melanocytes (2019, Homo sapiens,Mus musculus,Armoracia rusticana,Harvey murine sarcoma virus)
• Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches (2019, Gallus gallus,Danio rerio,Xenopus laevis,teleost fish,Xenopus tropicalis,Oreochromis niloticus,Coturnix japonica,Pimephales promelas,Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Adenoviridae,Ruditapes philippinarum)
• T Helper 9 Cells: A New Player in Immune-Related Diseases (2019, NA)
• Evolution of CIN+ tumors (2019, NA)
• Oncogenic activity of Bacteroides fragilis and Salmonella enterica (2019, Salmonella enterica,Bacteroides fragilis,Homo sapiens)
• Biological applications of light‐induced dimerization systems (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Agriosomyces longus,Avena sativa,Cereibacter sphaeroides,Rhodopseudomonas palustris,Homo sapiens)
• Inflammasome (2019, Mycobacterium tuberculosis,Helicobacter pylori,Streptococcus pneumoniae,Bacillus anthracis,Shigella flexneri,Streptococcus sp. group A,Coxiella burnetii,Acinetobacter lwoffii,Orthomyxoviridae,Vesicular stomatitis virus,Encephalomyocarditis virus,Enterovirus,Human rhinovirus sp.,Mengo virus,Saccharomyces cerevisiae,Candida albicans,Arachis hypogaea,Ambrosia artemisiifolia,Drosophila melanogaster,Pyroglyphidae,Homo sapiens,Mus musculus,prion,Bacteriophage sp.,NA,NA)
• TLR‐mediated signaling pathway (2019, Mycobacterium tuberculosis,Helicobacter pylori,Streptococcus pneumoniae,Bacillus anthracis,Shigella flexneri,Streptococcus sp. group A,Coxiella burnetii,Acinetobacter lwoffii,Orthomyxoviridae,Vesicular stomatitis virus,Encephalomyocarditis virus,Enterovirus,Human rhinovirus sp.,Mengo virus,Saccharomyces cerevisiae,Candida albicans,Arachis hypogaea,Ambrosia artemisiifolia,Drosophila melanogaster,Pyroglyphidae,Homo sapiens,Mus musculus,prion,Bacteriophage sp.,NA,NA)
• Schematic overview for the roles of miR-24, miR-23a and miR-145 in TGFB signaling in AKI (2019, NA)
• All currently known proteins required for germling communication and fusion in N (2019, NA)
• Ciona robusta cardiopharyngeal gene regulatory network and tunicate phylogeny (2019, NA)
• Schematic depicting the sensitization mechanism of CsA to crizotinib (2019, NA)
• Deletion of both cytosolic superoxide dismutases impacts metabolite concentrations and enzyme abundance of TCA cycle (A), glycolysis (B), and pentose phosphate pathway (C) (2019, Salmonella enterica,Homo sapiens)
• Enriched genes from the ANOVA statistically significant disease status gene list (p-value < 0.05) found in the KEGG Alzheimer's disease pathway (hsa05010) [Kanehisa and Goto, ; Kanehisa et al., , ] (2019, NA)
• Positive and negative feedback signals for neuronal polarization (2019, NA)
• Complement system (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Cavia magna,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Bikinia letestui,Neisseria meningitidis)
• Schematic representation that hypothesizes the effects of ethanol (A), THC and/or OEA (B) on neurotrophic signaling pathway via AKT and ERK1/2, and its neurogenic response in the hippocampus (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Nicotiana tabacum,Equus asinus,Cannabis sativa,Homo sapiens)
• Metacore™ map showing the signaling context of the genes contained in the “Vascular endothelial cell damage in SLE” pathway (2019, Homo sapiens)
• The Hippo signaling pathway-YAP/TAZ in human endothelial cells (2019, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Role of immune cells and TNF family members in regulating drug-induced liver damage (2019, NA)
• Network analysis of Ly6D, Ly6E, Ly6K, and Ly6H genes (2019, Homo sapiens,Mus musculus)
• Rationale and workflow of CRISPR-BEST (2019, NA)
• Schematic depiction of the CD38/CD203a/CD73 adenosinergic pathway as a major mechanism of the acquired resistance to anti-PD-1/PD-L1 blockade within the BM niche (2019, NA)
• The purinome in the MM environment under bone marrow niche metabolic reprogramming (2019, NA)
• Modes of MUC1 control of cellular inflammatory signaling pathways (2019, NA)
• Reversion of HIV-1 latency regulated by DCs (2019, Homo sapiens,Bos taurus,Human immunodeficiency virus 1,Matthiola incana)
• MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer (2019, NA)
• MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer (2019, NA)
• Th17 in non-atopic asthma (2019, Blattella germanica,Dermatophagoides farinae,Dermatophagoides pteronyssinus,Periplaneta americana,Blomia tropicalis,Homo sapiens,Diaporthe sclerotioides)
• Dauer signalling pathway model proposed for Haemonchus contortus (2019, NA)
• Mechanistic illustration of the effect of alcohol on the dysregulation of genes involving several metabolic pathways leading to alterations in serum metabolomic profiles (2019, NA)
• Mitogen-activated protein kinase (MAPK) signaling pathway and related miRNAs (2019, Gallus gallus,H9N2 subtype,Anser sp.,Avian leukosis virus evJ,Homo sapiens,Escherichia coli,NA)
• Map of molecular mechanisms involved in SRPK1 regulation in the apoptosis of intracranial aneurysm smooth muscle cells (2019, Rattus norvegicus,Homo sapiens)
• Costs of clinical trials with anticancer biological agents in an Oncologic Italian Cancer Center using the activity-based costing methodology (2019, NA)
• Broken TCA cycle in M1 macrophages (2019, Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Francisella tularensis,Trypanosoma cruzi,Toxoplasma gondii,Leishmania infantum,Dengue virus,Respiratory syncytial virus,Homo sapiens,Mus musculus,NA,NA)
• The cellular functions of the PLAC8 up-regulated genes (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Zea mays,Solanum lycopersicum,Schizosaccharomyces pombe,Eucalyptus intertexta,eudicotyledons,Pyrus communis,Saccharomyces cerevisiae S288C,Persea americana,Physalis pubescens,Oidiodendron maius,Escherichia coli,Escherichia coli IS5,Homo sapiens,Mus musculus)
• Proposed model for the induction of the Vps34-autophagy pathway in ETV6 RUNX1-positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells (2019, Homo sapiens,Mus musculus)
• Scheme for metabolic flux in stimulated platelets and sites of action of small-molecule modulators (2019, Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition (2019, NA)
• Localized decidualization in the cycling human endometrium (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Streptococcus sp. group B,Ulex europaeus)
• PI3K/Akt /mTOR pathway (2019, NA)
• Therapeutic strategies targeting mutant p53 (2019, Homo sapiens)
• Representative working modes of mutant p53 GOF (2019, Homo sapiens)
• Action of methylxanthine (MTXs) in glioblastoma (GBM) (2019, NA)
• Protein–protein interaction (PPI) network of the set of DEGs/DEPs identified in the overrepresented GO Immune System Process terms (2019, Influenza A virus,Dengue virus,Human betaherpesvirus 5,Betapolyomavirus macacae,Isavirus salaris,Sprivivirus cyprinus,Viral hemorrhagic septicemia virus,Piscine orthoreovirus,Spleen necrosis virus,Rock bream iridovirus,Gallus gallus,Oncorhynchus mykiss,Salmo salar,Salmo trutta,Dicentrarchus labrax,Teleostei,Oplegnathus fasciatus,Abramis brama,Channa argus,Homo sapiens,Mus musculus,Syringa vulgaris,Yersinia ruckeri,Gyrodactylus salaris)
• FOXK2 role as an oncogene in cancer (2019, NA)
• ADRB2 signaling in prostate cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Equus asinus x Equus caballus)
• Hypothetical sequentially coupled transduction pathway leading to the activation of VRAC by hypotonicity-induced cell swelling (2019, NA)
• Biogenesis and function of ribosomal RNA-derived fragments (2019, NA)
• RhoA/ROCK signaling (2019, NA)
• Diagram of Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways (2019, NA)
• Theoretical regulation of bevacizumab on claudin5 signaling pathway (2019, Homo sapiens)
• Citrate produced through mitochondrial metabolism can enter the fatty acid synthesis pathway (2019, Homo sapiens,Mus musculus)
• Schematic model for Cbl-b in BCR- and CD40-mediated signaling pathways Activation of CD40-dependent signaling pathway is mediated primarily by several TNFR-associated factor (TRAF) protein family members including TRAF2, 3, 5, and 6 (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Process and regulatory mechanism of autophagy (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanisms involved in the prooncogenic activation of the NRF2/KEAP1 pathway (2019, NA)
• Modulatory mechanisms of TRAIL extrinsic signaling pathway by E3 ligases and deubiquitinases (2019, Homo sapiens)
• Schematic of chemical-driven cell fate change and expansion (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• Proposed model for the role of RarA in adrenocortical development (2019, NA)
• Vascular endothelial growth factor (VEGF) binds to the VEGF receptor, a receptor tyrosine kinase, leading to receptor dimerization and subsequent auto phosphorylation of the receptor complex (2019, NA)
• Proposed model of cell signaling associated with the ALK5-SMAD2/3 tumor-suppressive arm identified by Monsivais et al (2019, NA)
• AhR−AREG axis defines a signaling pathway between cellular intrinsic redox mechanisms and surrounding TME (2019, NA)
• Critical roles of B3GalT5 and the globo-series GSLs in regulating the apoptosis and survival of breast carcinoma cells (2019, NA)
• Chemoautotroph Ca (2019, NA)
• The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases (2019, NA)
• G protein-coupled estrogen receptor 1 (GPER) activation triggers different signaling pathways on neurons and astrocytes (2019, NA)
• Signaling pathways participating in the function of cadherins in cancer (2019, Gallus gallus,Phoenicopterus roseus,Homo sapiens,Mus musculus,NA)
• AT-rich interactive domain 1A (ARID1A) chromatin remodeling abnormalities in ovarian clear cell carcinoma (OCCC) (2019, NA)
• Involvement and regulation of lncRNAs in M1‐like macrophage polarization (2019, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Moraxella bovis,Homo sapiens,Canis lupus familiaris,Candida dubliniensis,Porcine bocavirus 1)
• Poly(I:C)-toll-like receptor 3 signaling pathway and polarization of mesenchymal stem cells (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Schematic outline of major Btk signalling cascades (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,Dengue virus,Orthomyxoviridae,H1N1 subtype,Enterovirus C,Murine adenovirus 1,Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Shigella flexneri,Trypanosoma cruzi,Leishmania major,Leishmania amazonensis,Candida albicans,Aspergillus fumigatus,Homo sapiens,Mus musculus,NA)
• Effects of ASA in SK‐N‐SH (N) cells (2019, Homo sapiens,Mus musculus,Armoracia rusticana)
• Overall possible mechanism of CS-PAC-AgNPs induced mitochondrial apoptotic signaling pathway (2019, Danio rerio,Homo sapiens)
• Scheme of SUMOylation and deSUMOylation pathway (2019, Homo sapiens,Mus musculus)
• Possible mechanisms of the anti-tumor effects of bitter melon (2019, Momordica charantia,Homo sapiens)
• AMPK-dependent anticancer activities of honokiol in ovarian cancer cells (2019, Armoracia rusticana,herbal medicine,Magnolia officinalis,Impatiens balsamina,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Regulatory effects of H2S on PCSK9 expression and lipid metabolism (2019, NA)
• Schematic view of Scrophularia buergeriana extract (SBE) regulating reactive oxygen species (ROS) levels and the apoptotic signaling cascade (2019, NA)
• Hypoxia-inducible factor-1 (HIF-1) signaling pathway (2019, NA)
• Hypothesized pathways of volatile anesthetics induced neuropathology associated with Alzheimer’s disease (2019, NA)
• Schematic model of NMDAR-mediated signaling in GBM cells (2019, NA)
• Model illustrating BEFV-induced autophagy signaling pathways (2019, Bovine ephemeral fever virus,Human immunodeficiency virus 1,Hepatitis B virus,Adenoviridae,Influenza A virus,Dengue virus,Orthomyxoviridae,Vesicular stomatitis virus,Coxsackievirus B3,Lyssavirus rabies,Ebola virus sp.,Foot-and-mouth disease virus,Avian orthoreovirus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Cricetus cricetus,Homo sapiens,Bos taurus,NA)
• GnIH action at the hypothalamic-pituitary levels (2019, Gallus gallus,Coturnix coturnix,Coturnix japonica,Passer domesticus,Melospiza melodia,Mus musculus,Rattus norvegicus,Mesocricetus auratus,Phodopus sungorus,Homo sapiens,Macaca mulatta,Bos taurus)
• Pathway by which starvation induces a glucagon-mediated increase in liver autophagy (2019, Homo sapiens,Mus musculus)
• Canonical Notch signaling pathway (2019, Silybum marianum,Livistona chinensis,Rubus alceifolius,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Hepatitis B virus,clinical samples)
• CircRNA regulates cell proliferation (2019, Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Sus scrofa,Homo sapiens)
• GPs unmask cryptic variation in parallel signaling pathways and subpathways (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Matthiola incana,Drosophila melanogaster,Plasmodium falciparum,Homo sapiens,Mus musculus,Simian retrovirus 2)
• Calcium signaling pathway is overrepresented in the specific differentially expressed genes altered by alfalfa intervention during the preweaning period (2019, NA)
• Epigenetic regulation of stem cells (2019, NA)
• Histone chaperoning pathway: from ribosome to nucleosome (2019, Saccharomyces cerevisiae,Xenopus laevis,Schizosaccharomyces pombe,Triportheus paranensis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Schematic representation showing that B‐arrestin2 (ARRB2) negatively regulated NOD2 signalling pathway through the association with TRAF6 in cerebral ischaemia/reperfusion injury (2019, NA)
• Metabolism in tumor cells (2019, Saccharomyces cerevisiae,PX clade,Cryptococcus neoformans,Mus musculus,Rattus norvegicus,Escherichia coli,Oryctolagus cuniculus,Canis lupus familiaris,Mycobacterium tuberculosis,Human papillomavirus type 16,Rous sarcoma virus,Homo sapiens,NA)
• Illustration for cut-edges and the CTGs in AD pathway from KEGG (2019, NA)
• Visualization of resulting networks from Min-cut on the pathway of AD (2019, NA)
• Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma (2019, NA)
• Uxe function in biosynthesis of cell surface polysaccharides in S (2019, NA)
• Basic mechanisms of lithium function (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,unidentified)
• Molecular pathways targeted by the TCMs covered in this review are summarized (2019, herbal medicine,Panax ginseng,Salvia miltiorrhiza,Ginkgo biloba,Scutellaria baicalensis,Panax notoginseng,Melia azedarach,Carthamus tinctorius,Apium graveolens Dulce Group,Tripterygium wilfordii,Angelica sinensis,Polygonum cuspidatum,Wolfiporia cocos,Panax quinquefolius,Rheum palmatum,Ophiocordyceps sinensis,Paeonia suffruticosa,Magnolia officinalis,Rehmannia glutinosa,Astragalus mongholicus,Cnidium monnieri,Alpinia officinarum,Gynostemma pentaphyllum,Erigeron breviscapus,Dioscorea oppositifolia,Cornus officinalis,Oreocome striata,Phytolacca acinosa,Alisma plantago-aquatica,Aristolochia fangchi,Monochasma savatieri,Taxus celebica,Ophiocordyceps sobolifera,Mus musculus,Rattus norvegicus,Homo sapiens,Merluccius merluccius)
• Summary and functional network target analysis of ginsenoside Rb1, which exerts significantly anti-obesity, anti-hyperglycemic, and anti-diabetic effects on diabetes via multiple links across regulatory mechanisms and multi-target effects (2019, NA)
• Schematics presenting mechanisms of actions of approved and selected experimental cytokine and cytokine receptor agonists and antagonists (2019, NA)
• Complexity of GAL/SPX and receptor systems and pharmacological properties of SG2A (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Carassius auratus)
• Eukaryotic cell metabolism (2019, NA)
• The physiological generation and function of lipid mediators in immunity (2019, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Mycobacterium leprae,Mycobacterium marinum,Mycobacterium avium subsp. paratuberculosis,Streptococcus sanguinis,Mycobacterium avium complex sp.,Mycobacterium ulcerans,Mycobacterium intracellulare,Bos taurus,Trichosurus vulpecula,Homo sapiens,Mus musculus,Danio rerio,Candida dubliniensis)
• Mechanism of foam cell formation (2019, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Mycobacterium leprae,Mycobacterium marinum,Mycobacterium avium subsp. paratuberculosis,Streptococcus sanguinis,Mycobacterium avium complex sp.,Mycobacterium ulcerans,Mycobacterium intracellulare,Bos taurus,Trichosurus vulpecula,Homo sapiens,Mus musculus,Danio rerio,Candida dubliniensis)
• The Insulin Signalling Pathway and insulin resistance (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Spleen focus-forming virus)
• Hypothalamic regulation of energy homeostasis in healthy (blue) and obesity (pink) (2019, NA)
• Thyroid enlargement in patients with homozygous INSR mutation (2019, Homo sapiens)
• Schematic representation of the major components of the endosomal pathway and the generation of exosomes (2019, Saccharomyces cerevisiae,Solanum lycopersicum,Curcuma longa,Human immunodeficiency virus,Lyssavirus rabies,Homo sapiens,Mus musculus,Escherichia coli,Danio rerio,Capra hircus,NA)
• Working model of stiffness-dependent calcium response for neutrophils on HUVECs (2019, Bos taurus,Capra hircus,Pekania pennanti,Mus musculus,Rattus norvegicus,Homo sapiens)
• Inflammatory mediatorsA: Inflammatory mediators with mainly proatherogenic effects are mediated by interleukin-1(IL-1), interleukin-6 (IL-6), and tumor necrosis factorA (TNFA) through nuclear factor kappa beta (NFDB) signaling cascade (2019, NA)
• Novel IL-1Beta-ILC3-IL-2 circuit is essential for the maintenance of Tregs and immunologic homeostasis uniquely within the small intestine (2019, NA)
• Microarray and pathway analysis of two COMMA-DB derived clones reveal important differences relevant to their developmental capacity in-vivo (2019, NA)
• TLR4/NFKB pathway mediating miR-625-5p and COL1A1 in IDD pathogenesis (2019, Homo sapiens)
• Schema of ACh-muscarinic acetylcholine receptor 3 (M3R) signaling pathway in gastrointestinal (GI) tumor cells (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,Helicobacter pylori)
• The illustration of human IgG1 structure with N-glycan attached at Asn297 site in the CH2 of the Fc region (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,Nicotiana tabacum,Cricetulus griseus,Salmonella enterica,Komagataella pastoris,Escherichia coli str. K-12 substr. W3110,Homo sapiens,Canis lupus familiaris,Human immunodeficiency virus 1)
• Microarray and pathway analysis of two COMMA-DB derived clones reveal important differences relevant to their developmental capacity in-vivo (2019, NA)
• APR signaling pathway is associated with ozone exposure and bacterial infection (2019, NA)
• Complement activation triggers neuronal damage (2019, NA)
• The insulin-like growth factor system role in PMSC differentiation into the skeletal muscle (2019, Homo sapiens,Mus musculus,Bos taurus)
• Proposed mechanism by which type 2 diabetes (T2DM) and aerobic exercise can affect the brain and lead to alterations of hippocampal glucose metabolism with subsequent effects on synaptic plasticity-associated proteins (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Key components and potential pharmacological targets of Wnt signaling implicated in orofacial clefts (2019, Homo sapiens,Mus musculus)
• Crosstalk between Wnt, Cdh1, Bmp, TgfB and Fgf signaling pathways in orofacial clefts (2019, Homo sapiens,Mus musculus)
• AKR1C1-3 are involved in a pathway with 44 unique interactors (2019, Homo sapiens)
• Graphic summary for nifedipine-induced lipogenesis on renal tubular cell (2019, NA)
• Schematic overview of the TLR4 signaling pathway (2019, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Vesicular stomatitis virus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Inhibition of NFKB signaling can occur at different steps of its activation pathway (2019, NA)
• Shh signaling pathway in hepatocellular carcinoma (2019, NA)
• VEGFR structures and their specific ligands (2019, NA)
• Transcriptional changes of type I interferon (IFN-I) signaling pathway members in the cerebellum of canine distemper virus (CDV)-infected compared to control dogs (2019, NA)
• Optotherapeutic strategies: several optogenetic implants have already been tested in mice and proved to be functional to treat diabetes as well as erectile dysfunction (2019, Saccharomyces cerevisiae,Escherichia coli,Arabidopsis thaliana,Cereibacter sphaeroides,Avena sativa,Thermus thermophilus,Rhodopseudomonas palustris,Microbacterium aurantiacum,Vaucheria frigida,Neurospora crassa 49,Mus musculus,Rattus norvegicus,Cricetus cricetus,Drosophila melanogaster,Carybdea rastonii,Homo sapiens,Bos taurus,Vesicular stomatitis virus,synthetic gene)
• Pathway analysis shows the identified proteins and their respective interactions (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Aphyosemion alpha,Acanthamoeba polyphaga mimivirus)
• Bioinformatics analyses for the top two negatively co-expressed hub modules of SNHG7 in thyroid cancer (2019, Homo sapiens,Danio rerio)
• PPI networks and GO and KEGG pathway analyses for the top two positively co-expressed hub modules of SNHG7 in thyroid cancer (2019, Homo sapiens,Danio rerio)
• Nano-Hydroxyapatite Coating Promotes Porous Calcium Phosphate Ceramic-Induced Osteogenesis Via BMP/Smad Signaling Pathway (2019, NA)
• Diagram of microRNAs and their involved pathways to cancer hallmarks (2019, NA)
• Rapamycin (mTOR) signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Capra hircus)
• Traumatic brain injury induces long-lasting changes in immune and regenerative signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Traumatic brain injury induces long-lasting changes in immune and regenerative signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Generalized Toll-like receptor signaling mechanism, adapted from (2019, Adenoviridae,Human immunodeficiency virus,Enterovirus,Simian immunodeficiency virus,ssRNA viruses,dsRNA viruses,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Helicobacter pylori,Listeria monocytogenes,Aspergillus fumigatus,Toxoplasma gondii,Phytolacca americana,Homo sapiens,Danio rerio)
• Calvarial bone development and suture closure (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Regulation of osteoblast proliferation and differentiation by transcription factors (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Schematic diagram of EGCG anti-tumor mechanisms based on reverse docking (2019, NA)
• Proposed mechanical cues regulates Hippo signaling pathway in gastric tumorigenesis (2019, Homo sapiens,Drosophila melanogaster,Helicobacter pylori)
• Intracellular peptidoglycan (PGN) is detected by intracellular receptors and activates the NFKB signaling pathway in Drosophila melanogaster and human enterocytes (2019, Drosophila melanogaster,Homo sapiens)
• Schematic model of the mechanisms of the ANA-induced apoptosis and its synergies with the cell death inducing cytokines (2019, NA)
• Enriched extracellular matrix organization pathway in non-type subtype of bladder carcinoma cell lines (2019, NA)
• Impacts of mutations in the TGFB signaling transduction components contribute to PDAC development (2019, NA)
• Pathways involved in alcohol metabolism (2019, NA)
• Human adenovirus induced cell signaling and downstream immune responses in human keratocytes, highlighting the centrality of Src kinase (2019, Human immunodeficiency virus 1,Hepatitis B virus,Adenoviridae,Coronaviridae,Human alphaherpesvirus 1,Human immunodeficiency virus,Adeno-associated virus,Vaccinia virus,Betapolyomavirus macacae,Human coronavirus 229E,Human adenovirus 5,Foot-and-mouth disease virus,Polyomavirus sp.,Human papillomavirus types,Rift Valley fever virus,Human adenovirus sp.,Betapolyomavirus hominis,Subgroup C,Human adenovirus 2,Human enterovirus,Echovirus E1,Human adenovirus D37,Human mastadenovirus B,Tiger frog virus,Human mastadenovirus D,Human adenovirus 19,Human adenovirus D8,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Macaca mulatta,Matthiola incana,Aspergillus fumigatus,Gallus gallus,Staphylococcus aureus,Panthera leo)
• Transcriptional profiling of enzymes involved in type II fatty acid synthesis (FASII), glycerolipid synthesis in plastid (GLSp) and cytosol glycolysis (GLSc), and beta-oxidation (2019, Nannochloropsis sp.,Saccharomyces cerevisiae,Embryophyta,PX clade,Sequoia sempervirens,Chlamydomonas reinhardtii,Chlorophyta,Thalassiosira pseudonana,Dunaliella salina,Volvox carteri,Chlorella variabilis,Nannochloropsis oceanica,Ostreococcus sp. lucimarinus,Micromonas pusilla,Fistulifera solaris,Coccomyxa subellipsoidea,Ochrophyta,Cereibacter sphaeroides,NA,Homo sapiens)
• Rationale for combining immune checkpoint inhibitors with antiangiogenic drugs, anti-tumor immune response modulation adapted from Amin et al (2019, NA)
• The core components of the Hippo signaling pathway (2019, NA)
• Innate immune pathways inhibition by calicivirus infection (2019, Murine norovirus,Norwalk virus,Feline calicivirus,Murine norovirus 1,Rabbit hemorrhagic disease virus,Felid alphaherpesvirus 1,Norovirus GII.4,Tulane virus,Porcine sapovirus,Norovirus isolates,Feline picornavirus,Hom-1 vesivirus,Rabbit vesivirus,Oryctolagus cuniculus,Sus scrofa,Felis catus,Homo sapiens,Macaca mulatta,Mus musculus,gut metagenome,Salmo salar)
• Network analysis from RNA seq (2019, Human immunodeficiency virus 1,Influenza A virus,Coronaviridae,Dengue virus,Orthomyxoviridae,West Nile virus,Enterovirus C,Japanese encephalitis virus,Coxsackievirus B3,Enterovirus,Dengue virus type 2,Human rhinovirus sp.,Dengue virus group,Avian myeloblastosis virus,Alfalfa mosaic virus,Homo sapiens,Macaca mulatta,Aspergillus fumigatus,Sequoia sempervirens,Mus musculus,Aedes aegypti,NA,NA)
• Crosstalk between Wnt, Shh, primary cilia and other related signaling components in orofacial clefts (2019, Homo sapiens,Mus musculus)
• PPI network generated for the proteins encoded by the eight statistical driver genes (2019, Homo sapiens,Mus musculus,Phleum pratense,Panthera leo)
• Schematic view of the role of AvB3-int in PD-L1 expression and antitumor immunity (2019, NA)
• Metabolic pathway scheme summarizing changes in carbon, energy and photosynthesis metabolic pathways during tomato fruit ripening (2019, NA)
• Crosstalk between Wnt, RA and related signaling pathways in orofacial clefts (2019, Homo sapiens,Mus musculus)
• Activation of serotonin receptors (5-HT-R) initiates a signaling cascade that leads to the activation of extracellular signal-regulated kinases (ERK) (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• This study (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed working model of omega-3 PUFAs induced inhibitory effect on inflammation and autoimmunity (2019, Mus musculus,Rattus norvegicus,Hordeum vulgare,Olea europaea,Homo sapiens,Caenorhabditis elegans)
• Mechanism of neuroprotection mediated by dexmedetomidine in astrocytes and MCAO rats (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs (2019, Homo sapiens,Mus musculus,Armoracia rusticana,Adenoviridae)
• Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs (2019, Homo sapiens,Mus musculus,Armoracia rusticana,Adenoviridae)
• Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs (2019, Homo sapiens,Mus musculus,Armoracia rusticana,Adenoviridae)
• Kyoto Encyclopedia of Genes and Genomes pathway analysis in SK-BR-3 vs (2019, Homo sapiens,Mus musculus,Armoracia rusticana,Adenoviridae)
• Signaling pathways associated with tumorigenesis and combined treatments that alleviate drug resistance (2019, Homo sapiens)
• Cyclin D-CDK4/6-INK4-Rb pathway in breast cancer (2019, Homo sapiens)
• Signaling pathway mediating cardiovascular protection of OT (2019, NA)
• Functional analyses of five core clusters (2019, NA)
• New biologics and small molecules in inflammatory bowel disease: an update (2019, Homo sapiens,Bikinia letestui,JC polyomavirus)
• Changes in PUFA metabolomes are conserved across pharmacological and physiological models of skeletal muscle injury (2019, Homo sapiens,Mus musculus,Escherichia coli,Canis lupus familiaris,Parthenos sylvia)
• The proposed mechanism underlying TRPA1-mediated CMF transdifferentiation and cardiac fibrosis after MI injury (2019, Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Proposed mechanism through which Fucoidan-Sargassum impedes invadopodia formation in HCCLM3 cells (2019, NA)
• Relationship of the three diseases at gene, pathway, module, and function levels and the biological mechanism of T2DM, CML, and PCa (2019, NA)
• Proposed regulatory mechanism of melanin-regulating signaling pathways in C (2019, NA)
• Regulatory system of ERK1/2 signaling (2019, Rhus coriaria,Carya myristiciformis,Artemisia anomala,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Proposed signaling network of regulating the formation and development of seminal vesicle tumors in TRAMP mice (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Betapolyomavirus macacae)
• Pathway of Alzheimer's disease (2019, NA)
• Effect of WNT signaling on cancer immunosurveillance (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Immune exclusion through the Wnt/beta-catenin pathway (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Role of Wnt Proteins in T cells (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Network visualization analysis of “potential lipid markers-lipoproteins-TLR4/MyD88 signaling pathways” for anti-inflammatory effects of HLJDD (2019, Escherichia coli,Staphylococcus aureus,Streptococcus mutans,Streptococcus iniae,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Candida dubliniensis,Melia azedarach,Homo sapiens,Human immunodeficiency virus,Venustaconcha ellipsiformis)
• Glycolysis (2019, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• LRRK2 substrates involved in vesicle trafficking and synaptic transmission (2019, NA)
• Control of aerobic glycolysis by ERK and JNK signaling pathways in proliferating cells (2019, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• ERK- and JNK-mediated phosphorylation of PKM2 is at the crossroad between proliferation and apoptosis (2019, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• Regulation mechanism of ECM/integrin/EphA1‐mediated cell adhesion (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,clinical samples,Eucalyptus intertexta)
• Core cell metabolic pathways (2019, NA)
• Proposed regulatory network involved in Keratinocytes of Type 2 Diabetes (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Main strategies of immunomodulation (2019, Saccharomyces cerevisiae,Candida dubliniensis,Olea europaea,Vitis vinifera,Theobroma cacao,Linum usitatissimum,Staphylococcus aureus,Bacillus subtilis,Lacticaseibacillus casei,Akkermansia muciniphila,Mus musculus,Rattus norvegicus,Human betaherpesvirus 5,Human alphaherpesvirus 3,Homo sapiens,gut metagenome)
• PDGF effects in periosteum derived progenitor cells and its interaction with BMP2/Smad signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus,Meleagris gallopavo)
• Schematic models of molecular targets affected by ISE to attenuate inflammatory signaling pathways (2019, NA)
• Internalization and cellular trafficking of FGFRs (2019, NA)
• Disorders resulting from mutational defects in the SL synthesis pathway for ceramide and GSLs and the nonlysosomal SL degradation pathway (2019, NA)
• Disorders resulting from mutational defects in the lysosomal SL degradation pathway (2019, NA)
• Canonical Wnt/B‐catenin and divergent signaling pathways (2019, Homo sapiens,Mus musculus,Danio rerio)
• Clinal candidates in the insulin/TOR signaling pathway (2019, Drosophila melanogaster,Homo sapiens)
• Mutual interactions of the mitochondrial compartment with hepatitis viruses and the consequences on the infections (2019, Mus musculus,Rattus norvegicus,Meriones unguiculatus,Hepatitis B virus,Hepatovirus A,Homo sapiens,prion,NA,NA)
• KEGG pathways for TCA cycle and retinol metabolism in the T 6 vs (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Monodelphis domestica)
• IGF signalling pathway alterations occurring in cisplatin‐resistant TGCT (2019, NA)
• Complement system and crosstalk with other innate immune effector systems in liver IRI, regeneration, and transplantation (2019, Mus musculus,Rattus norvegicus,Escherichia coli,Canis lupus familiaris,Sus scrofa,Neisseria meningitidis,Homo sapiens,Lareunionomyces loeiensis)
• Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma (2019, NA)
• Rational combinations of PARPi with other targeted agents (2019, Homo sapiens)
• String network of proteins (encoded by the differentially expressed genes (DEGs)) involved in signalling pathways (2019, NA)
• Co-expression analysis of genes overexpressed in Puławska pigs, characterized by high feed conversion values (2019, NA)
• Pituitary Transcriptional Response Related to Feed Conversion in Pigs (2019, NA)
• Functional analysis of significantly changed proteins (SCPs) (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecules and cellular pathways that contribute to thyroid cancer development (2019, NA)
• Schematic diagram on the molecular mechanism of the anti-adipogenic effect of 10-HDA in 3 T3-L1 preadipocytes (2019, NA)
• Activation of autophagy process by extracellular vesicles (2019, NA)
• KEGG AMPK signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Candida dubliniensis)
• Pathway of energy metabolism and ginsenoside synthesis (2019, Panax ginseng,Homo sapiens)
• Redifferentiation of thyroid cancer (2019, Homo sapiens,Rattus norvegicus)
• Rac3-mediated mechanisms in cancer (2019, NA)
• TLR4–p38B MAPK–C/EBPB signaling pathway mediates the coordinate activation of UPP and ALP in cancer-induced muscle catabolism (2019, NA)
• A Novel Tanshinone Analog Exerts Anti-Cancer Effects in Prostate Cancer by Inducing Cell Apoptosis, Arresting Cell Cycle at G2 Phase and Blocking Metastatic Ability (2019, herbal medicine,Salvia miltiorrhiza,Homo sapiens,Mus musculus,Helicobacter pylori)
• Hypothetical signalling pathway that illustrates how the various pathways in this review may be connected, which is partially informed by preliminary research (2019, NA)
• Simplified TGFB pathway leading to p21 expression (2019, NA)
• Map of potential pathways and their potential interactions activated by a soluble factor- radiation-induced bystander effect (RIBE) signal (2019, NA)
• Proposed action mechanism of 6SL (2019, Scutellaria baicalensis,Serenoa repens,Homo sapiens,Rattus norvegicus,Canis lupus familiaris)
• Schematic diagram for apoptosis induced by KRG extract (2019, NA)
• Schematic drawing presents the detailed signaling pathways of breast carcinogenesis (2019, NA)
• Diallyl trisulfide (DATS) protected the brain tissue against the damage induced by ischemia/reperfusion (IR) (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Allium sativum,Homo sapiens)
• Scheme of the de novo synthesis pathway of glutathione (2019, NA)
• Coelonin inhibiting LPS-stimulated activation of NFKB and inducing G1 phase cell-cycle arrest in RAW264.7 cells (2019, NA)
• Key metabolic pathway and regulatory network in mutant ptsd1 (2019, Arabidopsis thaliana,Armoracia rusticana,Nicotiana tabacum,Oryza sativa,Zea mays,Triticum aestivum,Hordeum vulgare,Panax ginseng,Brassica napus,Sorghum bicolor,Liliopsida,Dianthus caryophyllus,Triticum turgidum,Puccinia striiformis f. sp. tritici,Triticum dicoccoides,Homo sapiens,Venustaconcha ellipsiformis)
• Chemotherapy-induced apoptosis and pyroptosis in cancer cell (2019, NA)
• Molecular mechanisms involved in inflammasome activation (2019, NA)
• Hyperglycemia associated metabolic reprogramming in cancer cells and potential targets (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Human gammaherpesvirus 4,NA)
• Apoptosis pathways (hsa04210) and targets of cordycepin (2019, NA)
• Key metabolic remodeling and potential therapeutic targets in glioblastoma (GBM) (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Splenic sympathetic nerve-mediated anti-inflammatory pathway after stroke (2019, NA)
• DNA damage response network in SCLC cells (2019, Homo sapiens,Mus musculus,NA)
• Tumour necrosis factor receptor 1 (TNFR1) signalling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,prion)
• Regulation of EMT at different molecular levels: upregulation of the WNT pathway, PI3K/AKT pathway, and RAS/RAF/MEK/ERK/MAPK pathway and downregulation of the TGFB/Smad pathway lead to the activation of EMT through downregulation of E-cadherin (2019, Homo sapiens,Mus musculus)
• Bone metastasis physiopathology: implication of cancer cell-microenvironment interactions and therapeutic targets (2019, NA)
• Biological origin of free radicals and their effect on cell viability (2019, NA)
• Three major branches of the Unfolded Protein Response (UPR) signaling pathway and their interconnections (2019, NA)
• TGFB signaling in cholangiocarcinoma (CCA) progression (2019, Fasciola hepatica,Clonorchis sinensis,Opisthorchis viverrini,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Veratrum californicum,NA)
• Basics of transforming growth factor B (TGFB) signaling (2019, Fasciola hepatica,Clonorchis sinensis,Opisthorchis viverrini,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Veratrum californicum,NA)
• Mechanism of optimal therapeutic drugs in each subtype of breast cancer (2019, Homo sapiens)
• Specific crosstalk network of each breast cancer subtype (2019, Homo sapiens)
• Hepatic synthesis of glutathione and nutritional substrates, co-factors, and other nutrients that influence metabolism (2019, Saccharomyces cerevisiae,Solanum lycopersicum,Malus domestica,Cucumis sativus,Curcuma longa,Spinacia oleracea,Brassica oleracea,Ginkgo biloba,Punica granatum,Salvia rosmarinus,Silybum marianum,Persea americana,Sinapis alba,Nasturtium officinale,Brassica oleracea var. viridis,Platanus racemosa,Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori,Human immunodeficiency virus)
• Our model of the BRAF mutation positive mitogen-activated protein kinase (MAPK) pathway signaling mechanisms (2019, Armoracia rusticana,Syringa vulgaris,Homo sapiens,Ovis aries)
• Substance P/neurokinin-1 receptor (SP/NK-1R) system regulates several cell signaling pathways involved in cancer progression (2019, NA)
• Mechanism of TRA/GO action (2019, NA)
• HER2 signaling pathway (2019, NA)
• Differentially expressed genes in the cyclic AMP (cAMP) signaling pathway between mandarin fish in the control group (CG) and the learning group (LG) from a transcriptome analysis (2019, NA)
• Differentially expressed genes in the neurotrophin signaling pathway between mandarin fish at CG and LG from a transcriptome analysis (2019, NA)
• Anthocyanins on pro-survival and pro-apoptotic signaling pathways (2019, NA)
• Pathway shows the influence of adipocytes on cancer (2019, Homo sapiens,Mus musculus)
• miRNA-responsive biological pathways and the presence or absence of interactions between its genes and the transfected miRNA (2019, Bos taurus,Canis lupus familiaris,Sus scrofa,Eutheria,Monodelphis domestica,Gallus gallus,Xenopus laevis,Xenopus tropicalis,Gallirallus australis,Homo sapiens,Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Venustaconcha ellipsiformis,Pan troglodytes,Ligustrum vulgare)
• Interference of hepatitis C virus (HCV) with the nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)/ Keap1-signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Hepatitis B virus,NA,NA,NA)
• The different Transforming Growth Factor B (TGFB) family members on articular cartilage biology and osteoarthritis (OA) development (2019, NA)
• Transforming growth factor B (TGFB) family SMAD-independent signaling (2019, NA)
• Transforming growth factor B (TGFB) family SMAD-dependent signaling (2019, NA)
• How solid stress signal transduction via Akt pathway regulates GDF15 expression to induce pancreatic cancer cell migration (2019, Homo sapiens,Mus musculus,Bos taurus)
• Simple depiction of signaling pathways for the activation of classical NLRP3 inflammasome (canonical and non-canonical) and alternative inflammasome (2019, NA)
• Metabolic pathway of classic and non-classic androgens (2019, Homo sapiens,Bos taurus,Danio rerio)
• Apoptotic pathways triggered by inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors (2019, Mus musculus,Rattus norvegicus,Bos taurus,Human immunodeficiency virus 1,DNA viruses,Elephas maximus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Receptors used by chemerin, visfatin, resistin and apelin for their signaling pathways (2019, Human immunodeficiency virus 1,Coronaviridae,Human immunodeficiency virus,Simian immunodeficiency virus,Homo sapiens,Mus musculus,Rattus norvegicus,Cricetulus griseus,Pan troglodytes,Papio hamadryas,Bos taurus,Gallus gallus,Meleagris gallopavo,Actinobacillus pleuropneumoniae,Haemophilus ducreyi,Scotophilus heathii)
• Ligand-dependent EGFR signaling pathways (2019, NA)
• Downregulation of G2/mitotic-specific cyclinB1 triggers autophagy via AMPK-ULK1-dependent signal pathway in nasopharyngeal carcinoma cells (2019, NA)
• Schematic summarizing the molecular mechanisms contributing to cancer progression (2019, NA)
• Mutation Hotspots in the Beta-Catenin Gene: Lessons from the Human Cancer Genome Databases (2019, NA)
• Retrograde signalling and cellular adaptations (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Pathway of the investigated genes involved in apoptosis (2019, NA)
• Flavonoids as anti-diabetic agents: Modes of Action (2019, Glycine max,Solanum lycopersicum,Solanum tuberosum,Malus domestica,Arachis hypogaea,Cucumis sativus,Fragaria x ananassa,Spinacia oleracea,Brassica oleracea,Allium cepa,Theobroma cacao,Allium sativum,Daucus carota,Ginkgo biloba,Pyrus communis,Ipomoea batatas,Scutellaria baicalensis,Solanum melongena,Citrus x paradisi,Petroselinum crispum,Citrus limon,Brassica juncea,Apium graveolens Dulce Group,Brassica rapa subsp. pekinensis,Fagopyrum esculentum,Citrus reticulata,Origanum vulgare,Prunus dulcis,Vaccinium myrtillus,Syringa vulgaris,Psidium guajava,Hypericum perforatum,Citrus trifoliata,Citrus aurantiifolia,Citrus aurantium,Hippophae rhamnoides,Opuntia ficus-indica,Vaccinium angustifolium,Oroxylum indicum,Scutellaria lateriflora,Euonymus alatus,Levisticum officinale,Oenanthe javanica,Passiflora caerulea,Prunus davidiana,Apium graveolens Secalinum Group,Pelargonium crispum,Tilia tomentosa,Millettia duchesnei,Tridax procumbens,Scrophularia nodosa,Mus musculus,Rattus norvegicus,Mesocricetus auratus,aerobic bacillus,Brevundimonas bacteroides,Melittangium lichenicola,Homo sapiens,Influenza A virus,Opsanus beta,Apis mellifera,NA,NA)
• HSP90 functions as a mediator of many oncogenic and signaling pathways (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Sus scrofa,Homo sapiens,herbal medicine)
• Anti-apoptotic and cell survival activities of some HSPs in cancer (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Sus scrofa,Homo sapiens,herbal medicine)
• Genetic network and functions of PSGs (positively selected genes) related with the KEGG pathway of the PPAR signaling pathway, fat digestion and absorption, vitamin digestion and absorption (2019, Mus musculus,Rattus norvegicus,Glycine max,Candida dubliniensis,Homo sapiens,Sus scrofa,Gammarus fossarum)
• Proteasome pathway mapping of altered genes in DLD-1-miR-21 cells (2019, Armoracia rusticana,Nicotiana tabacum,Homo sapiens)
• Possible mechanism of action underlying the protective effects of maltol against APAP-induced hepatic injury through inhibition of oxidative stress-mediated activation of the NFKB pathway and apoptosis and regulation of the PI3K/Akt pathway (2019, NA)
• Identification of Radioactive Iodine Refractory Differentiated Thyroid Cancer (2019, Homo sapiens)
• Anti-autophagic and anti-apoptotic pathway activated in human DCs by P (2019, NA)
• Tumor microenvironment shapes NK cell metabolism and effector functions (2019, Homo sapiens,Mus musculus)
• BK ablation attenuates osteoblast bone formation via integrin pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana)
• Manipulation of the interferon signaling pathway in myeloid cells (2019, Human immunodeficiency virus 1,Human immunodeficiency virus,Simian immunodeficiency virus,Human immunodeficiency virus 2,HIV-1 group M,HIV-1 group O,HIV-1 group N,Homo sapiens,Macaca mulatta,Chlorocebus aethiops,Cercocebus atys,Mus musculus,Matthiola incana,Simian-Human immunodeficiency virus)
• MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/Beta-catenin signaling (2019, Homo sapiens,Mus musculus)
• MiR-708 expression gradient is reduced during the transformation from normal prostate epithelial cells through adenocarcinoma cells to NEPC (2019, Homo sapiens,Mus musculus)
• Mechanisms underlying the loss of primary cilia frequently observed in cancer cells with aberrant RTK (2019, NA)
• Roles of omental and bone marrow adipocytes in tumor biology (2019, Candida dubliniensis,Candida dubliniensis CD36,Homo sapiens,Mus musculus)
• Sirtuins and metabolism (2019, Homo sapiens,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae,Plasmodium falciparum)
• Role of TRPML1 in the regulation of ERK signaling in cells harboring HRASG12V mutations (2019, NA)
• KIT mutant GISTs have enrichment for KEGG cell cycle pathway (p = 0.0007) and spliceosome pathway (p = 0.0008) using STRING v10 clustering of significantly somatic mutated genes (p < 0.003) (2019, Homo sapiens)
• Nrf2 signaling cascade (2019, Candida dubliniensis,Camellia sinensis,Lentinula edodes,Mus musculus,Rattus norvegicus,Homo sapiens)
• Canonical and noncanonical signaling pathways of NOD1 and NOD2 (2019, NA)
• Cyclooxygenase (COX) pathway and prostaglandin E2 (PGE2) signaling (2019, Homo sapiens,Mus musculus)
• Schematic diagram showing PR/RANKL pathway and downstream RANK-mediated signaling in mammary epithelial cells (2019, Homo sapiens,Mus musculus)
• Promotion of Peripheral Nerve Regeneration by Stimulation of the Extracellular Signal‐Regulated Kinase (ERK) Pathway (2019, NA)
• Effect of corilagin on the TGFB signaling pathway in ovarian cancer (2019, Saccharomyces cerevisiae,herbal medicine,Catharanthus roseus,Punica granatum,Taxus brevifolia,Jatropha curcas,Crocus sativus,Dimocarpus longan,Vinca minor,Phyllanthus emblica,Pelargonium x hortorum,Terminalia chebula,Phyllanthus niruri,Terminalia arjuna,Phyllanthus amarus,Phyllanthus urinaria,Nephelium lappaceum,Saururus chinensis,Terminalia bellirica,Parthenium hysterophorus,Terminalia catappa,Solanum virginianum,Euphorbia pekinensis,Excoecaria agallocha,Acer rubrum,Pelargonium reniforme,Arctostaphylos uva-ursi,Macaranga tanarius,Acer nikoense,Vincetoxicum pycnostelma,Phyllanthus debilis,Canarium album,Zanthoxylum piperitum,Euphorbia prostrata,Mallotus japonicus,Libidibia coriaria,Geranium thunbergii,Persicaria chinensis,Geranium carolinianum,Acalypha australis,Lumnitzera racemosa,Cunonia macrophylla,Terminalia citrina,Bauhinia variegata,Acer palmatum subsp. amoenum,Acalypha hispida,Geranium wilfordii,Alchornea glandulosa,Acalypha wilkesiana,Caraipa densifolia,Phyllanthus tenellus,Phyllanthus ussuriensis,Erodium cicutarium,Phyllanthus muellerianus,Erodium stephanianum,Geranium sibiricum,Geranium pyrenaicum,Nymphaea nouchali,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Thereva major,Homo sapiens,Hepatitis B virus)
• Protein C activation by the thrombin-thrombomodulin complex and the cytoprotective function of Activated Protein C (APC) in ischemic heart disease and heart failure (2019, NA)
• Multiple levels of MKP regulation in fungi (2019, NA)
• Mitogen-activated protein kinase (MAPK) signaling pathways in model fungi (2019, NA)
• The effect of corilagin on the Notch-mTOR signaling pathway in cholangiocarcinoma (2019, Saccharomyces cerevisiae,herbal medicine,Catharanthus roseus,Punica granatum,Taxus brevifolia,Jatropha curcas,Crocus sativus,Dimocarpus longan,Vinca minor,Phyllanthus emblica,Pelargonium x hortorum,Terminalia chebula,Phyllanthus niruri,Terminalia arjuna,Phyllanthus amarus,Phyllanthus urinaria,Nephelium lappaceum,Saururus chinensis,Terminalia bellirica,Parthenium hysterophorus,Terminalia catappa,Solanum virginianum,Euphorbia pekinensis,Excoecaria agallocha,Acer rubrum,Pelargonium reniforme,Arctostaphylos uva-ursi,Macaranga tanarius,Acer nikoense,Vincetoxicum pycnostelma,Phyllanthus debilis,Canarium album,Zanthoxylum piperitum,Euphorbia prostrata,Mallotus japonicus,Libidibia coriaria,Geranium thunbergii,Persicaria chinensis,Geranium carolinianum,Acalypha australis,Lumnitzera racemosa,Cunonia macrophylla,Terminalia citrina,Bauhinia variegata,Acer palmatum subsp. amoenum,Acalypha hispida,Geranium wilfordii,Alchornea glandulosa,Acalypha wilkesiana,Caraipa densifolia,Phyllanthus tenellus,Phyllanthus ussuriensis,Erodium cicutarium,Phyllanthus muellerianus,Erodium stephanianum,Geranium sibiricum,Geranium pyrenaicum,Nymphaea nouchali,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Thereva major,Homo sapiens,Hepatitis B virus)
• Mechanism of CB-R-mediated antitumor activity in breast cancer cells (2019, Homo sapiens,Mus musculus,Canis lupus familiaris,Mouse mammary tumor virus,Cannabis sativa)
• ERK1/2 regulate IL-10 transcription via MSK1/2 dependent and independent mechanisms (2019, Saccharomyces cerevisiae,Nicotiana tabacum,Oryza sativa,Zea mays,Hordeum vulgare,Candida albicans,Panax ginseng,Agaricus bisporus,Musa acuminata,Aspergillus oryzae,Thymus vulgaris,Sclerotinia sclerotiorum,Aloe vera,Lentinula edodes,Trametes versicolor,Pleurotus ostreatus,Saccharomyces boulardii nom. inval.,Ambrosia artemisiifolia,Aureobasidium pullulans,Grifola frondosa,Hydrastis canadensis,Agaricus blazei,Trypanosoma cruzi,Apis mellifera,Leishmania major,Leishmania donovani,Plasmodium berghei,earthworms,Mesocestoides corti,Eimeria vermiformis,Escherichia coli,Staphylococcus aureus,Bacillus anthracis,Serratia marcescens,Lacticaseibacillus rhamnosus GG,Streptococcus suis,Streptococcus suis SC5,Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Pan troglodytes,Gorilla gorilla,Pongo pygmaeus,Gallus gallus,Dipnomorpha,Oreochromis niloticus,H5N1 subtype)
• General representation of the signaling pathways involved in the antagonism of both ionotropic and metabotropic glutamate receptors in anti-cancer mediated effects (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• IL-36 signaling pathway (2019, Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis H37Rv,Homo sapiens,Mus musculus,Candida albicans,Human alphaherpesvirus 2)
• Partly hypothetical model describing the characteristic shifts of balance within the sphingomyelin/salvage pathway attributed to immune low and immune high tumor subtypes/subgroups of patients (2019, Homo sapiens,Mus musculus,Oryctolagus cuniculus,NA)
• Cell cycle regulation in GCs of small follicles (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Cricetus cricetus,Equus asinus,Homo sapiens)
• SNG mediated action in MM cells (2019, Bos taurus,Oryctolagus cuniculus,Ginkgo biloba,Sanguinaria canadensis,Homo sapiens,Mus musculus,Calloplesiops altivelis)
• Mechanisms supporting BRAF inhibitor resistance in melanoma (2019, Homo sapiens,Mus musculus)
• Pervasive regulation of TLR signaling pathway by miR-146a/b family and miR-125a~99b~let-7e cluster (2019, NA)
• Cell cycle‐non specific mechanisms for the resistance to CDK4/6 inhibitors (2019, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Sirtuins and B lymphocytes (2019, Homo sapiens,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae,Plasmodium falciparum)
• Differentially expressed coat color genes in Changthangi Pashmina goat and their involvement in melanogenesis signaling pathway (Adapted from ref.) (2019, NA)
• PTP1B modulates IL-8 production via a SFK-Akt-GSK-3-C/EBPß pathway (2019, NA)
• Major biological processes highlighted by pathway analysis of genome-wide association studies including 29 391 coronary artery disease cases and 66 819 controls (2019, Homo sapiens,Mus musculus)
• Proposed CLIC4/Arf6 signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus,NA)
• Possible mechanisms contributing to the inhibition of fat synthesis and glucose utilization of M (2019, Momordica charantia,Glycine max,Panax ginseng,Arachis hypogaea,Cucumis sativus,Vicia faba,Prunus armeniaca,Cucumis melo,Trigonella foenum-graecum,Platycodon grandiflorus,Gardenia jasminoides,Jasminum officinale,Vicia faba var. minor,Cucurbita maxima,Alcea rosea,Mus musculus,Rattus norvegicus,Mesocricetus auratus,Streptococcus thermophilus,Lactobacillus delbrueckii subsp. bulgaricus,Homo sapiens,Gallus gallus,NA)
• Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome (2019, Homo sapiens,Mus musculus,Malus domestica)
• Schematic overview of the mevalonate pathway (2019, NA)
• Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif is a point of convergence in signaling pathways (2019, NA)
• The proposed cardioprotective mechanism of mAb A treatment in hearts following a myocardial infarction (2019, NA)
• Kinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility (2019, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Meleagris gallopavo)
• Relationships of the top differentially expressed genes within the top GSEA gene sets (2019, Homo sapiens,Macaca mulatta,Pan troglodytes,Macaca fascicularis,Mus musculus,Rattus norvegicus)
• Nonalcoholic fatty liver disease-Kyoto Encyclopedia of Genes and Genomes pathway and mechanisms of disease pathogenesis (2019, NA)
• Significant metabolic pathways, Ubiquitin‐mediated proteolysis pathway and Adherens junction and Wnt signaling pathway for regulated genes associated with IS‐SM when compared to IS‐NSM (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Regulation of neutrophil metabolism (2019, NA)
• Key metabolic pathways in neutrophils (2019, NA)
• SMI suppressed Ang II–induced cardiomyocyte hypertrophy and apoptosis through the activation of the AMPK signaling pathway via energy-dependent mechanisms (2019, NA)
• Molecular mechanism of S1P signaling via its receptors (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Role of the biomarkers explored in the study on EGFR signaling (2019, Homo sapiens)
• Proposed working model (2019, Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Regulation of the main phases of the autophagic pathway by the C2‐WW‐HECT E3s (2019, Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Parabacteroides chongii,Human immunodeficiency virus 1,Hepatitis B virus,Homo sapiens,Mus musculus,Equus asinus x Equus caballus)
• Mechanism of neuroprotective and antioxidant effects of genistein by interacting with estrogen receptor (2019, Glycine max,Phyllanthus emblica,Asparagus racemosus,Phyllanthus reticulatus,Baccaurea ramiflora,Mus musculus,Rattus norvegicus,Bacillus subtilis,Vibrio harveyi,Homo sapiens,Caenorhabditis elegans)
• Mechanism of neuroprotective effects of genistein against neuropathological insults of Alzheimer’s disease (2019, Glycine max,Phyllanthus emblica,Asparagus racemosus,Phyllanthus reticulatus,Baccaurea ramiflora,Mus musculus,Rattus norvegicus,Bacillus subtilis,Vibrio harveyi,Homo sapiens,Caenorhabditis elegans)
• EGL-9 inhibits the HIF-1 target NHR-57 from reducing RAS/MAPK signaling through a DELTA/NOTCH-induced negative feedback loop (2019, Caenorhabditis elegans,Homo sapiens)
• DEGs are potentially related to Alzheimer’s relevant pathways and functions (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,unidentified,Amomum maximum)
• MAPK/MKP3 signaling network and application of caged cysteine toward caging the catalytic site of the phosphatase (2019, Homo sapiens,Escherichia coli,Danio rerio)
• Laser Microdissection-Based Tissue-Specific Transcriptome Analysis Reveals a Novel Regulatory Network of Genes Involved in Heat-Induced Grain Chalk in Rice Endosperm (2019, NA)
• Regulation of the C-type lectin receptor signalling pathway by curdlan and MacroGard® (2019, Gallus gallus,Danio rerio,teleost fish,Cyprinus carpio,Salmo salar,Oreochromis niloticus,Paralichthys olivaceus,Ictalurus punctatus,Takifugu rubripes,Sparus aurata,Pagrus pagrus,Anguilla anguilla,Cyprinus carpio carpio,Haplochromis chilotes,Homo sapiens,Saccharomyces cerevisiae,Aspergillus fumigatus,Gorilla gorilla,Mus musculus,Bos taurus,Alcaligenes faecalis)
• Cell damage in peripheral neurons caused by cigarette smoking (2019, NA)
• Pathogen antioxidant networks: The examples of Mtb and T (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Mycobacterium tuberculosis variant bovis BCG,Bacillus subtilis At2,Escherichia coli IS1,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Mycobacterium tuberculosis H37Rv,Drosophila melanogaster,Trypanosoma cruzi,Trypanosoma brucei,Leishmania major,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Models for the roles of Scribble in organizing molecular interactomes involved in synaptogenesis, epithelial polarity, and adhesion, and growth regulation (2019, NA)
• Scar tissue to lung cancer; pathways and treatment (2019, Homo sapiens,Mus musculus)
• Identification of key regulatory genes connected to NFKB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia phage T7)
• Feedback loops based on self-sustaining kinase activation or translation, hypothesized to play roles in maintaining persistent LTP and LTM (2019, NA)
• EBV latent and lytic proteins on inhibition of apoptosis (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,NA)
• Notch pathway promotes drug resistance by regulating cancer cell survival, glycolytic switch and cancer stem cells (2019, NA)
• RUNX3 and p53 act independently and in concert to elicit their tumour suppressive function (2019, Homo sapiens,Mus musculus,Capsaspora owczarzaki,NA)
• Ten simple rules to create biological network figures for communication (2019, NA)
• Regulation of fatty acid oxidation, mevalonate pathway, and arachidonic acid metabolism by p53 (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,unidentified shuttle vector)
• Whole driver PC3-represented PCa signaling pathway (2019, NA)
• LC1405 neuroprotective pathway against amyloidB peptide (AB)-induced toxicity (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Carica papaya,Homo sapiens)
• Putative mechanism of necroptosis and relative inflammatory responses during the development of CCI (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus,Celithemis elisa)
• Strategies for immunomodulation to mitigate periprosthetic osteolysis induced by wear particles (2019, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Suggestive model for receptor-mediated pathway involved in CD biology (2019, NA)
• Kynurenine pathway with a focus on KYNA synthesis (2019, Anopheles gambiae,Pyrococcus horikoshii)
• Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations (2019, Bos taurus,Eutheria,Elephas maximus,Delphinus delphis,Tursiops truncatus,Orcinus orca,Balaena mysticetus,Ursus maritimus,Physeter catodon,Hippopotamus amphibius,Balaenoptera acutorostrata,Lipotes vexillifer,Phocoena phocoena,Odobenus rosmarus,Odobenus rosmarus divergens,Balaenoptera musculus,Leptonychotes weddellii,Cetacea,Delphinapterus leucas,Tursiops aduncus,Mysticeti,Manis pentadactyla,Arctocephalus gazella,Hexaprotodon liberiensis,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,gut metagenome)
• Cystathionine Beta-synthase (CBS) deficiency suppresses erythropoiesis by disrupting expression of heme biosynthetic enzymes and transporter (2019, Feline leukemia virus,Homo sapiens)
• MKK7/JNK signaling pathway (2019, NA)
• Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02870b (2019, NA)
• Interaction between reprogramming to pluripotency and tumorigenesis (2019, Bos taurus,Sus scrofa,Ovis aries,Bubalus bubalis,Mus musculus,Rattus norvegicus,Homo sapiens,Matthiola incana)
• Schematic model for the possible E2 uptake pathways in leukocytes (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Middle East respiratory syndrome-related coronavirus,NA)
• The mTOR-signaling pathway in ASD (2019, NA)
• Scheme for the MKK7-dependent JNK pathway (2019, NA)
• Different ncRNAs regulate PDCD4 in mutiple ways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Enrichment in multiple cancer-associated networks in breast cancer (2019, Homo sapiens,Mus musculus)
• Mechanistic network analysis predicts multiple affected signaling networks (2019, Homo sapiens,Mus musculus)
• Schematic overview of gene expression regulation of fatty acid oxidation and tricarboxylic acid (TCA) cycle in tPVAT and IAT (2019, Mustela putorius furo,Mustela lutreola,Nyctereutes procyonoides,Mustela erminea,Mustela putorius,Mus musculus,Rattus norvegicus,Homo sapiens,Didymium minus,Thiocystis minor)
• Functional overview of the embryonic complement system (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis)
• Exemplary metabolic pathways transcriptionally affected by oleuropein in Lactobacillus plantarum WCFS1 (2019, Escherichia coli,Pseudomonas putida,Lactiplantibacillus plantarum,Bacillus thuringiensis,Lactiplantibacillus pentosus,Dickeya chrysanthemi,Lactiplantibacillus plantarum WCFS1,Latilactobacillus sakei,Dickeya dadantii,Arabidopsis thaliana,Nicotiana tabacum,Solanum lycopersicum,Olea europaea,Origanum vulgare,Verticillium dahliae,Ligustrum vulgare,Homo sapiens)
• Abbreviated summary of monocyte activation pathways (2019, NA)
• Activation of NFKB in ITME (2019, Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Citrus deliciosa,Glossogyne tenuifolia,Homo sapiens,Mus musculus,NA)
• PIN1 acts at multiple levels of cooperating cellular pathways (2019, Saccharomyces cerevisiae,Candida albicans,Aspergillus nidulans,Neurospora crassa,Danio rerio,Xenopus laevis,Raphus cucullatus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus,Plasmid pTF1)
• AMF secretion and interaction with GPER-1, which drive EC progression (2019, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Homo sapiens,Mus musculus,prion,clinical samples)
• Signaling pathway proposed in this study (2019, Homo sapiens,Mus musculus,Bos taurus,Caenorhabditis elegans)
• Important signaling pathways that govern the differentiation of pancreatic conversion and the mechanism of action of different small molecules and peptides reported on pancreatic differentiation from MSC (2019, Homo sapiens,Mus musculus,NA)
• KEGG pathway analysis of the differentially expressed genes in head and neck squamous cell carcinoma (2019, Homo sapiens,Caenorhabditis elegans)
• STC1 expression and cell invasion (2019, NA)
• Glutamine-dependent regulation of BMSC osteogenic and adipocyte differentiation (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Mitogen-activated protein kinase signaling pathway in lung squamous cell carcinoma (2019, NA)
• Signaling pathways by which NPs induce apoptosis (2019, Homo sapiens)
• Wnt/Beta-catenin signaling as a useful therapeutic target in hepatoblastoma (2019, NA)
• Illustration of pathway signalling where phosphorylation signalling PTMs have been sequenced and annotated in melanoma tumours from patients (2019, NA)
• New targeted therapies in advanced primary cutaneous anaplastic large cell lymphoma (2019, NA)
• Proposed model (2019, Homo sapiens,Mus musculus,Corynephage beta)
• Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis (2019, NA)
• Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis (2019, NA)
• Autophagy signaling pathways induced by NPs (2019, Homo sapiens)
• MHtt aggregation, generation of ER stress and the consequent UPR protective and later pro-apoptotic responses (2019, NA)
• Schematic overview of genetic and epigenetic abnormalities in Wnt pathway components in MM and drugs that target canonical Wnt signaling (2019, NA)
• Adipocytes represent a central player in the creation of the metabolic tumor microenvironment in the omentum during ovarian cancer metastasis (2019, Homo sapiens,Mus musculus)
• Biological pathways associated with non-synonymously mutated genes in TCL1 mice (2019, NA)
• Hypothetical mechanism underlying the inhibition of palmitic acid-induced lipid accumulation by apigenin in HepG2 cells (2019, NA)
• TGF-ß signaling pathway (2019, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Equus caballus,Homo sapiens,Adenoviridae)
• Main synthesis pathway of n-3 long-chain PUFA-derived lipid mediators (2019, NA)
• Signaling pathway regulation network of the three validated differentially expressed tRFs (2019, NA)
• T-cell receptor signaling pathway (2019, NA)
• The inflammasome as a gear or cogwheel that couples purinergic signaling with the complement cascade (ComC) in the process of HSPC mobilization (2019, NA)
• Regulation of the BMP signaling pathway (2019, NA)
• The ubiquitylation of glycoprotein (GP) VI signalling pathway (2019, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Re-analysis of 15 selected genes by KEGGpathway enrichment (2019, NA)
• Transcriptional reprogramming of the H-series strains H14, 20, 27, and 31 at 24 h post-induction of gene expression (2019, NA)
• Schematic overview of the brassinosteroid pathway components that are targeted by BPC6 in vivo (2019, NA)
• Model illustrates the mechanism for the effect of DAPT on modulating F-actin polymerization through PI3K/AKT/Cdc42 signaling by Non-canonical Notch pathway during cancer cell migration (2019, NA)
• Distribution of target proteins of hesperidin in the “Alzheimer’s disease pathway” (2019, NA)
• Distribution of target proteins of dihydromyricetin within the “Alzheimer’s disease pathway” (2019, NA)
• Ginsenoside Rb1 prevent the steroid-induced avascular necrosis of the femoral head through BMP-2 and VEGF signaling pathway (2019, Armoracia rusticana,Panax ginseng,Panax notoginseng,Homo sapiens,Rattus norvegicus)
• STRING connectivity network demonstrating a protein–protein interaction network of predicted functional partners for differentially expressed genes in the brown module (2019, NA)
• Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Sugar metabolism pathway components and corresponding heat-map expression profiles of sugar-related genes in 6-BA treated buds of ‘Nagafu No.2’ apple (2019, NA)
• Mechanism diagram depicting that the miR-193a-5p/DPEP1 axis affects the progression of HB through the PI3K/Akt/mTOR signaling (2019, NA)
• Classes of drugs that modulate the cGMP-PKG pathway in relation to SERCA2a within cardiac myocytes (cardiomyocytes) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,gut metagenome,Carpinus caroliniana)
• Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Common signaling pathway for IL-1 family cytokines (2019, NA)
• Engineering the mitochondrial isobutanol biosynthetic pathway in a xylose-utilizing strain of S (2019, Saccharomyces cerevisiae,Homo sapiens)
• The mechanism by which Rel/NFKB-dependent STING expression activates antiviral autophagy to restrict ZIKV infection in fly brain (2019, NA)
• Core metabolism for growth on methanol with MIDs for key metabolites (2019, NA)
• LPS-TLR4-NFKB signaling pathway in metabolic disorders (2019, NA)
• Peptide/amino acid transport and metabolism and cofactor synthesis in Gs and Au cells (2019, NA)
• Distribution of target proteins of icariin within the “Alzheimer’s disease pathway” (2019, NA)
• Distribution of target proteins of baicalin in the “Alzheimer’s disease pathway” (2019, NA)
• MiR-155 is expressed in plasma (P), monocytes, fibroblast-like synoviocytes (RASF) and synovial fluid monocytes (SFCD14*C) of patients with RA/JIA (2019, NA)
• Schematic diagram of the pathogen-derived molecules used to escape cytokine-sensing pathways in cells (2019, NA)
• Interplay between HPV-infected keratinocytes and the local immune microenvironment critically influences cervical carcinogenesis.HPV suppresses inflammatory signaling in the host keratinocyte (2019, NA)
• Overview on the principles of canonical and non-canonical NFKB pathways activation (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Biogenesis of mature, secreted clusterin involves the traditional secretory pathway common to other secreted proteins (2019, Homo sapiens)
• Tbx1-Isl1-Met genetic pathway regulates only a subset of CPM-derived muscles (2019, NA)
• Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor (2019, Mus musculus,Rattus norvegicus,Rickettsia slovaca,Allochromatium vinosum,Homo sapiens,Armoracia rusticana)
• Summary of molecular basis on which epigallocatechin-3-gallate (EGCG) prevents chronic kidney disease (CKD) and renal fibrosis based on preclinical evidence (2019, NA)
• Interaction between BAs and the TGR5 signaling pathwayThese are three major metabolic pathways in the TGR5 signaling pathway (2019, Homo sapiens)
• Brief conclusion of miR-27a in regulating cell signal pathways Panel gray, miR-27a can regulate Ras/MAPK/ERK pathway to active key gene such as c-myc (2019, Hepatitis B virus,Saimiriine gammaherpesvirus 2,Homo sapiens,Rattus norvegicus,Caenorhabditis elegans)
• Implication of hexosamine biosynthetic pathway on the NLRP3 inflammasome (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Triticum aestivum,Human T-cell leukemia virus type I)
• Schematic description of TLR7-mediated enhancement of CD8+ T cell function (2019, Homo sapiens,Mus musculus,Hepatitis B virus,Pan troglodytes,Marmota monax,Woodchuck hepatitis virus)
• Functional mechanisms of COL2A1 on the BMP-SMAD1 pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Possible integrated mechanism of cell injury and its relationship with microcephaly ZIKV-induced and cell death (2019, NA)
• Lithium chloride with immunomodulatory function for regulating titanium nanoparticle-stimulated inflammatory response and accelerating osteogenesis through suppression of MAPK signaling pathway (2019, NA)
• Challenges of driving CD30-directed CAR-T cells to the clinic (2019, NA)
• Lung microenvironment: an important regulator of tumour growth and metastasis (2019, NA)
• Active constituent-protein targets-signaling pathway network of frankincense–myrrh compound against breast cancer (2019, Olea europaea,Pelargonium x hortorum,Acorus calamus,Boswellia sacra,Commiphora myrrha,Boswellia serrata,Cyperus papyrus,Commiphora mukul,Commiphora wightii,Boswellia papyrifera,Boswellia frereana,Boswellia neglecta,Protium heptaphyllum,Boswellia rivae,Commiphora guidottii,Commiphora erythraea,Commiphora quadricincta,Commiphora kua,Commiphora sphaerocarpa,Escherichia coli,Staphylococcus aureus,Bacillus cereus,Proteus mirabilis,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Molva molva,Schistocerca gregaria)
• Translational regulation in response to glucose availability: The presence of glucose results in the activation of PKA promoting high levels of protein biogenesis (2019, Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Aspergillus fumigatus,Aspergillus nidulans,Aspergillus niger,Cryptococcus neoformans,Crateva religiosa,Cryptococcus amylolentus,Homo sapiens,Mus musculus,Danio rerio,Mycobacterium tuberculosis,environmental samples,Acanthamoeba castellanii)
• Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage (2019, NA)
• Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury (2019, NA)
• KEGG Pathview readouts of DEX vs Control-associated differential gene expression (2019, NA)
• Erythropoietin (Epo) binds to the Epo receptor (EpoR) to activate erythroid-specific gene transcription (EpoR, globins, glycophorin A (GPA), and miR-144/451) by GATA-1, resulting in hemoglobin (Hb) production (2019, NA)
• Proposed signaling pathway involved in EXD against TNF-Alpha-induced cell damage (2019, Ganoderma lucidum,Angelica sinensis,Gynochthodes officinalis,Epimedium sagittatum,Epimedium koreanum,Aspalathus linearis,Anemarrhena asphodeloides,Salvia divinorum,Phellodendron chinense,Curculigo orchioides,Bombax ceiba,Magnolia officinalis var. officinalis,Homo sapiens,Rattus norvegicus)
• Schematic depicting the proposed molecular mechanism by which citrate regulates cellular redox signaling pathways in BMSCs (2019, NA)
• How insulin-stimulated cleavage of TUG and subsequent trafficking of GSVs coordinately regulates multiple physiologic effects (2019, NA)
• Schematic summary of the molecular pathways of F (2019, NA)
• Syntenin-mediated signaling in the regulation of membrane structure and cell motility (2019, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Venustaconcha ellipsiformis,Homo sapiens,NA)
• Canonical and non-canonical signaling of FGF23 (2019, NA)
• The different expression of HH (hedgehog) signaling (2019, Homo sapiens,Mus musculus,Gallus gallus,Sus scrofa,Mouse mammary tumor virus)
• The Fas/Fas-L pathway (2019, Homo sapiens,Mus musculus,Nicotiana tabacum,Helicobacter pylori,Hepatitis B virus)
• Signaling pathway of DNAM-1 receptor (2019, Homo sapiens,Mus musculus,Nicotiana tabacum,Helicobacter pylori,Hepatitis B virus)
• Model describing the distinct fates of NK cells during NK cell education (2019, NA)
• Signaling pathways involved in the AVP-dependent myogenic differentiation (2019, NA)
• Isoflurane (ISO) cardiac preconditioning (2019, NA)
• Stress-induced senescence (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Human alphaherpesvirus 1,Prevotella sp.)
• Signaling pathways involved in the switch between proliferation and dormancy (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Signaling pathway of DNA damage response (DDR) in the context of chromatin (2019, NA)
• Endoplasmic reticulum (ER) stress-mediated inflammation (2019, NA)
• Canonical and alternative Wnt signaling pathways (2019, NA)
• Elevated FAM83A expression in pancreatic cancers is driven by a MEK/ERK-JUNB-driven feed-forward signalling loop (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Matthiola incana)
• Schematic diagram of EB virus involved in the G1/S transition (2019, NA)
• PI3K/Ras signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Leptin regulates fatty acid oxidation in muscle by activating AMPK (2019, Homo sapiens,Mus musculus)
• Vitamin D pathway (2019, Homo sapiens,Mus musculus)
• Intrinsic cancer cell pathways mediate the regulation of PD-L1 expression and MHC in EGFR-mutant NSCLC (2019, NA)
• Major hallmark of immunosuppression in the TME through diverse pathways in EGFR-mutant NSCLC (2019, NA)
• DAMPs exposure (2019, Homo sapiens)
• Significance of bioactive sphingolipids in neurodegeneration (2019, Homo sapiens)
• The PI3K-Akt-mTOR signaling by bioactive sphingolipids (2019, Homo sapiens)
• Graphical abstract shows the protective mechanism of SFN against Ar-induced damage in the kidney tissue via PI3K/Akt-mediated Nrf2 signaling pathway (2019, Rattus norvegicus,Homo sapiens)
• Rectal cancer sub-clones respond differentially to neoadjuvant therapy (2019, Homo sapiens)
• Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition (2019, NA)
• Tumor Necrosis Factor Receptor 1 (TNFR-1) Signalling Pathway (2019, NA)
• CD28 KO reverses lung blast injury by the PI3K/Akt/FoxO1 signaling pathway (2019, NA)
• Results of network analysis: differentially regulated proteins from the SILAC approach are indicated in green (TCam-2) or in red (NTERA-2) (2019, Homo sapiens,Mus musculus)
• Mechanisms of Yi Guan Jian Decoction in Chronic Hepatitis B Patients with Liver Fibrosis (2019, NA)
• Summary of mammalian Sia metabolism and the Neu5Ac-activated signaling pathway in cardiomyocyte (2019, NA)
• Network modeling of the epithelial-to-mesenchymal transition (EMT) (2019, NA)
• Proposed mechanisms of the pro-apoptotic effect on human GC AGS and BGC-823 cells induced by pholidonone (2019, Sarcodon aspratus,Coelogyne cantonensis,Homo sapiens)
• Cross-talk between DNA damage and immune response (2019, NA)
• DNA single-strand break and double-strand break repair pathways (2019, NA)
• TAAR1 signaling pathway/apoptotic pathway components (2019, Homo sapiens,Mus musculus)
• Executable pathway analysis using ensemble discrete-state modeling for large-scale data (2019, Respiratory syncytial virus,H1N1 subtype,Homo sapiens,Mus musculus,Parthenos sylvia)
• Petri net–based model of the human DNA base excision repair pathway (2019, NA)
• Simplified schematic of the RAS-RAF-MEK-ERK signaling pathway, the mutation sites and frequencies of key effectors, and their representative targeted inhibitors (2019, Homo sapiens,Mus musculus,Canis lupus familiaris)
• How the RAM (regulation of Ace2 and morphogenesis) and the CWI (cell wall integrity) pathways regulate the transition between growth and quiescence (2019, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,prion,Aphyosemion alpha)
• Proposed model illustrating the roles of CHL1 during NPC carcinogenesis (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human gammaherpesvirus 4,clinical samples)
• Molecular mechanisms of KLF15 in renal fibrosis and mesangial pathology (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Regulatory mechanism of calcium on HIF1A induction (2019, Mus musculus,Rattus norvegicus,Homo sapiens,prion)
• Exposure to high fat diets over time, enriched in saturated fatty acids, would promote the glial activation and an increased mitochondrial oxidative stress (2019, Mus musculus,Rattus norvegicus,Gallus gallus,Olea europaea,Curcuma longa,Uria aalge,Homo sapiens,prion)
• Complement-platelet interactions that can facilitate an inflammatory response that favors atheroma formation (2019, NA)
• Dacarbazine and PLX4032 cross-resistance emerges via distinct MAPK-dependent and -independent pathway activation (2019, Homo sapiens,Armoracia rusticana)
• Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019, NA)
• Terminal telomeric complex (2019, Homo sapiens,Arabidopsis thaliana)
• Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison (2019, Mus musculus,Rattus norvegicus,Zea mays,Pisum sativum,Homo sapiens,Danio rerio)
• Mechanism of ROCK1 promoting tumor cell migration, invasion and progression in NSCLC (2019, NA)
• Major pathways converging on uncontrolled growth in Drosophila epithelial cells (2019, NA)
• Metabolic pathway of aerial and submerged mycelia in the liquid surface culture of Cordyceps militaris (2019, Cordyceps militaris,Homo sapiens)
• Metabolic profiles influence macrophage inflammatory status (2019, NA)
• The signaling cascade activated by the CaSR that induces the arrival of ZO-2 to TJs (2019, NA)
• IIP-effectors in FOXJ1 regulatory network and their probable ciliary associations (2019, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Plasmodium falciparum)
• Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy (2019, Escherichia coli,Human alphaherpesvirus 1,Human immunodeficiency virus,Escherichia coli 14A,Homo sapiens)
• Biological functions of IL-32 in non-inflammatory tumors (2019, Helicobacter pylori,Hepatitis B virus,Human papillomavirus,Homo sapiens,Mus musculus,NA)
• Biological functions of IL-32 in inflammatory tumors (2019, Helicobacter pylori,Hepatitis B virus,Human papillomavirus,Homo sapiens,Mus musculus,NA)
• Upstream factors of the TOR pathway (2019, NA)
• CD44v6 engages in colorectal cancer progression (2019, NA)
• Summary of ventral midline crossing (2019, NA)
• Seminal fluid and semen induce expression changes in honeybee queen brains for genes mapping to the phototransduction pathway of Drosophila in both Experiment 1 (A) and Experiment 2 (B) (2019, NA)
• Schematics shown miRNAs which might regulate mGluR/mTOR/LTD signaling (2019, NA)
• Pathway map assigned for MAPKs signalling (2019, NA)
• Identification of DEGs relevant to protein processing in the endoplasmic reticulum pathway (2019, NA)
• CD44v6 engages in colorectal cancer progression (2019, NA)
• Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae (2019, NA)
• Regulation of B cell receptor (BCR) signaling on B cell survival (2019, Homo sapiens,Mus musculus,Oryza sativa,Human gammaherpesvirus 4)
• Scheme summarizing the role of TRP channels in cardiac fibrosis (2019, NA)
• HMGB1, as a priming signalling, involved in the stress-neuroinflammation-mesolimbic dopaminergic pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Melia azedarach)
• GnRH-stimulated signaling pathways that regulate Fshb gene expression (2019, NA)
• Modular network regulation map of gene-related ncRNA/TFs (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Role of Fyn in misfolded Alpha-synuclein (ASyn)-mediated NLRP3 inflammasome activation (2019, NA)
• Lung adenocarcinoma treatment and emerging therapeutic potential of targeting macrophages (2019, NA)
• P2X7 activation induces cell death via different molecular pathways depending on the cell type (2019, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Delphinus delphis,Lama glama,Homo sapiens)
• Phosphorylation of central carbon metabolic enzymes (2019, Zymomonas mobilis,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Bacillus subtilis,Corynebacterium glutamicum,Klebsiella pneumoniae,Bacillus anthracis,Lactococcus lactis,Streptomyces coelicolor,Synechocystis sp. PCC 6803,Synechocystis sp.,Synechococcus elongatus PCC 6301,phototrophic bacterium,Azotobacter vinelandii,Rhodopseudomonas palustris,Alphaproteobacteria,Halobacterium salinarum,Streptomyces coelicolor A32,Betaproteobacteria,Streptomyces collinus,Saccharomyces cerevisiae,Erythrobasidium elongatum,Mus musculus,NA,Homo sapiens)
• SCD-associated oxidative stress pathways and antioxidant systems (2019, NA)
• Metabolism in WSSV-infected hemocytes showing the aerobic glycolysis, glutamine metabolism and lipogenesis pathways at the WSSV genome replication stage (12 hpi) (2019, NA)
• Summary of the role of TTC7A in intestinal epithelial cells and the consequences of its mutation (2019, NA)
• CD44v6 engages in colorectal cancer progression (2019, NA)
• CD44v6 engages in colorectal cancer progression (2019, NA)
• miR-155 role in increased ROS production: miR-155 increases ROS production by silencing SOCS, a negative regulator of the JAK/STAT signaling pathway, a pathway known to play a role in ROS generation (2019, NA)
• Predictive biomarkers for bevacizumab efficacy in breast cancer (2019, Homo sapiens,Mus musculus)
• Canonical Hh signaling (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• CD44v6 engages in colorectal cancer progression (2019, NA)
• Non-nociceptive roles of opioids in the CNS: opioids’ effects on neurogenesis, learning, memory and affect (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Papaver somniferum,Phytomonas oxycareni,Pteropus alecto retrovirus)
• MicroRNA-146bb induces the PI3K/Akt/NFKB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN (2019, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Momordica charantia,Homo sapiens)
• Proposed schematic representation of the immune response to MERS-CoV infection and how the invading virus is processed during an infection (2019, Hepatitis B virus,Influenza A virus,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Adeno-associated virus,Vaccinia virus,H5N1 subtype,unidentified human coronavirus,Human adenovirus 5,Influenza A virus H3N2,Modified Vaccinia Ankara virus,Bos taurus,Oryctolagus cuniculus,Camelus dromedarius,Homo sapiens,Mus musculus,recombinant coronavirus,NA,NA)
• Signaling in HIV-1-mediated inflammation (2019, NA)
• DAXX in cell death (2019, NA)
• Signaling pathways involved in ICA-mediated BMSC proliferation, osteogenesis, angiogenesis, and migration (2019, herbal medicine,Epimedium brevicornu,Epimedium grandiflorum,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Drosophila melanogaster)
• Epidermal growth factor receptor Pathway and its two pathways: Ras/Raf/Mitogen-activated protein kinases or PI3K/AKT (2019, NA)
• Predicted model for Ras-MAPK pathway controlling the differentiation of workers into neotenic reproductives (2019, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Termitoidae,Zootermopsis nevadensis,Reticulitermes speratus,Reticulitermes flavipes,Reticulitermes santonensis,Reticulitermes labralis,Homo sapiens)
• Networks related to immune modulation and inflammatory response (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Streptococcus sp. group B)
• Pyroptosis in cancer: pro-cancer or pro-“host”? (2019, Salmonella enterica subsp. enterica serovar Typhimurium,Bacillus anthracis,Shigella flexneri,Francisella tularensis,Homo sapiens,Mus musculus,Human alphaherpesvirus 2)
• Consequences of indoleamine 2,3 dioxygenase (IDO) overexpression on the antitumoral immune response (2019, NA)
• Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway (2019, Homo sapiens)
• Dual prey-inactivation strategy of the venom of C (2019, Cupiennius salei,Drosophila melanogaster,Bombyx mori,Apis mellifera,Ixodes scapularis,Tetranychus urticae,Pleocyemata sp.,Rhipicephalus microplus,Ixodes ricinus,Amblyomma americanum,Limulus polyphemus,Rhipicephalus sanguineus,Parasteatoda tepidariorum,Tachypleus tridentatus,Phoneutria nigriventer,Latrodectus hesperus,Mesobuthus martensii,Amblyomma cajennense,Tityus serrulatus,Sagmariasus verreauxi,Xibalbanus tulumensis,Amblyomma triste,Cyriopagopus schmidti,Stegodyphus mimosarum,Conus marmoreus,Hadogenes troglodytes,Amblyomma parvum,Nephila pilipes,Conus textile,Simulium vittatum,Androctonus bicolor,RTA clade,Amilenus aurantiacus,Tityus obscurus,Atypus piceus,Trittame loki,Isometroides vescus,Lychas buchari,Hadrurus spadix,Dolomedes fimbriatus,Hadronyche infensa,Eratigena atrica,Megacormus gertschi,Viridasius fasciatus,Oxyopes heterophthalmus,Alopecosa marikovskyi,Ancylometes rufus,Cupiennius getazi,Tegenaria atrica,Haplopelma hainanum,Macrothele gigas,Brachypelma vagans,Phoneutria reidyi,Tenebrio obscurus,Agelena orientalis,Superstitionia donensis,Oxyopes lineatus,Lachesana tarabaevi,Lycosa singoriensis,Tityus bahiensis,Synsphyronus apimelus,Cheiracanthium punctorium,Atrax robustus,Hadronyche versuta,Agelenopsis aperta,Latrodectus tredecimguttatus,Polybetes pythagoricus,Centruroides hentzi,Xysticus cristatus,Gallus gallus,Calloplesiops altivelis,Naja kaouthia,Dendroaspis polylepis polylepis,Bombina maxima,Draco fimbriatus,Solanum tuberosum,Aspergillus niger,Manihot esculenta,Mus musculus,Rattus norvegicus,Homo sapiens,Wisteria badnavirus 1,NA)
• Ingenuity pathway analysis networks related to neurological disease are presented in this figure (A,B) (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Streptococcus sp. group B)
• The potential molecular pathways representing potential targets for treatment in patients with ACC, based on the results presented in the current review (2019, Homo sapiens,Mus musculus,NA)
• Proposed scheme of the antitumor effects of DIFs (2019, NA)
• Network analysis of differentially expressed genes (2019, Homo sapiens,Sequoia sempervirens,Avena sativa,Gorilla gorilla,Mus musculus)
• Pattern Diagram of SFRP blocking the WNT pathway (2019, NA)
• In the DP-treated cells, DP preferentially recognized and activated EGFR receptors on the cell surface (2019, Armoracia rusticana,Diaporthe sclerotioides,Panax ginseng,Artemisia annua,Centella asiatica,Croton lechleri,Dracaena cambodiana,Pterocarpus officinalis,Bos taurus,Oryctolagus cuniculus,Equus caballus,Camelus bactrianus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Proposed scheme for the glucose uptake-promoting effect of DIFs (2019, NA)
• Optimal management of atypical hemolytic uremic disease: challenges and solutions (2019, Escherichia coli,Streptococcus pneumoniae,Haemophilus influenzae,Neisseria meningitidis,Homo sapiens,Ovis aries,Cinchona pubescens)
• The proposed mechanism of FAM289 in GBM cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Musa acuminata,Homo sapiens,Xenopus laevis,clinical samples)
• Axon death signalling across species (2019, NA)
• Intracellular signaling pathways involved in initiation and perpetuation of hepatic stellate cell activation (2019, NA)
• Schematic summary for the protective effects of escin on APAP-induced liver injury in mice (2019, NA)
• Proposed model for the roles of Wnt/Beta-catenin signaling regulated by quercetin in protection of BBB breakdown (2019, NA)
• Pathway altered on both transcriptomic and epigenomic levels (2019, Homo sapiens,Mus musculus)
• Proteins in the glycolysis, tricarboxylic acid, and oxidative phosphorylation pathways examined by the Ingenuity Pathway Analysis software (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Escherichia coli,vectors,Sequoia sempervirens)
• Scheme of proposed IS-induced apoptosis via ROS-NRF2 and MAPK signaling pathways in human astrocytes (2019, Homo sapiens,Sequoia sempervirens,Avena sativa,Gorilla gorilla,Mus musculus)
• Effects of mutant Kras in reprogramming amino acid metabolism (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Zn2+-induced mitochondrial dysfunction is a critical and targetable early contributor to ischemic neuronal injury (2019, NA)
• Protein–protein interaction network of associated genes in the etiopathogenesis of ANCA-associated vasculitis (2019, Homo sapiens)
• TNF-related apoptosis-inducing ligand (TRAIL)-induced signaling pathways (2019, Homo sapiens)
• Major calcium channels, pumps, exchangers and sensors in mammalian cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta)
• Schematic model of METTL3 in regulating CRC (2019, NA)
• Differentiated insulin-producing cells (IPCs) for transplantation (2019, NA)
• Transfection with GAB increases the sensitivity of GBM cell lines T98G, U87MG, and LN229 to H2O2-induced oxidative stress (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Regulation of intestinal organoid formation by different growth factors (2019, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Helicobacter pylori,Clostridioides difficile,Homo sapiens)
• Signaling pathways of proteins with different concentration (2019, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana,Cyprinus carpio)
• Biliary tract cancers: current knowledge, clinical candidates and future challenges (2019, Mus musculus,Rattus norvegicus,Fasciola hepatica,Opisthorchis viverrini,Homo sapiens,Bikinia letestui,human metagenome)
• Intracellular signaling pathways of FFAR1-mediated HASM cell proliferation (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Neuroimmune interactions and kidney disease (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Chlamydomonas reinhardtii,Mustela putorius furo,Merluccius merluccius)
• WDR92 in the axonemal dynein assembly pathway (2019, Saccharomyces cerevisiae,Embryophyta,PX clade,Magnoliopsida,Chlamydomonas reinhardtii,Eucalyptus intertexta,Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Amoebozoa,Danio rerio,Bellapiscis medius,Homo sapiens)
• Biosynthesis of AhR ligands from tryptophan metabolism (2019, Nicotiana tabacum,Brassica oleracea,Wolfiporia cocos,Tropicoporus linteus,Alisma plantago-aquatica subsp. orientale,Polyporus umbellatus,Escherichia coli,Clostridium sporogenes,Arthrobacter pascens,Mus musculus,Rattus norvegicus,gut metagenome,human gut metagenome,Homo sapiens)
• AhR transcription in mammalian cells and the putative mechanism of AhR activation (2019, Nicotiana tabacum,Brassica oleracea,Wolfiporia cocos,Tropicoporus linteus,Alisma plantago-aquatica subsp. orientale,Polyporus umbellatus,Escherichia coli,Clostridium sporogenes,Arthrobacter pascens,Mus musculus,Rattus norvegicus,gut metagenome,human gut metagenome,Homo sapiens)
• circRNAs and the Warburg effect associated signaling pathways (2019, Homo sapiens,Mus musculus)
• Altered metabolic pathways and associated circRNAs in cancer (2019, Homo sapiens,Mus musculus)
• Pre-synaptic and post-synaptic mechanisms regulated by PPT1 (2019, NA)
• SnoRD126 activates the PI3K-AKT signaling pathway through FGFR2 and snoRD50A/B and affects the MAPK signaling cascades (2019, Homo sapiens)
• CAMP signalling pathway (2019, NA)
• Functional roles of SALL4 in cervical cancer cells (2019, NA)
• Based on our findings, there are several crucial paths, including PI3/AKT/mTOR as well as HIF-1A activation (in hypoxia) and inhibition (in normoxia) (2019, NA)
• Schematic overview of metabolic pathways of P (2019, NA)
• Schematic diagram depicting CCN1 induction of tip cell identity through interplay of integrin AvB3/VEGFR2 with Hippo pathway (2019, Homo sapiens,Mus musculus,Danio rerio)
• Small molecules enhance knock-in efficiency (2019, Porcine circovirus 2,Peanut clump virus,Porcine endogenous retrovirus,Human adenovirus E4,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Mus musculus)
• Contrasting Patterns of Rapid Molecular Evolution within the p53 Network across Mammal and Sauropsid Lineages (2019, Gallus gallus,Coturnix coturnix,Xenopus tropicalis,Tetrapoda,Amniota,Zootoca vivipara,Chrysemys picta bellii,Python bivittatus,Pelodiscus sinensis,Caretta caretta,Podarcis muralis,Sauropsida,Sphenodon punctatus,Emys orbicularis,Mus musculus,Cavia porcellus,Elephas maximus,Heterocephalus glaber,Metatheria,Cryptomys hottentotus,Balaena mysticetus,Myotis brandtii,Homo sapiens,Drosophila melanogaster,Zea mays)
• Model of the effect of the Ras/Erk vs. the PI3k/Akt pathways (2019, Mus musculus,Rattus norvegicus,Betapolyomavirus macacae,Rous sarcoma virus,Homo sapiens,Xenopus laevis)
• NMII knockdown cells show altered gene expression (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Olea europaea,Homo sapiens,Mus musculus,NA)
• Model of TNFR2-mediated regulation of NFKB transcriptions factors in Tregs (2019, NA)
• TNFR2 can modulate TNFR1 signaling (2019, NA)
• MCSP- and ABCB5-enriched CTCs exhibit distinct transcriptional programming (2019, NA)
• Hypothetical network of metabolism in F (2019, NA)
• Tumor necrosis factorA signaling in gastric cancer (2019, Helicobacter pylori)
• Pathway inhibition by targeted agents and their effects on cell proliferation, apoptosis, metastasis and angiogenesis (2019, Homo sapiens,Mus musculus,Human gammaherpesvirus 8)
• IL-38 signaling pathways (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Candida albicans,Candida albicans 11C,Homo sapiens,Adeno-associated virus)
• Hypothetical model for adenoviral regulation of stress-induced EGFR signaling through NFKB (2019, Hepatitis B virus,Adenoviridae,Human alphaherpesvirus 1,Human T-cell leukemia virus type I,Coxsackievirus,Human adenovirus 5,Human adenovirus sp.,Human adenovirus 2,Human adenovirus E4,Human adenovirus 12,Human adenovirus D37,Human mastadenovirus C,Human adenovirus 52,Mus musculus,Rattus norvegicus,Homo sapiens)
• Adenovirus-directed innate immunity through nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) (2019, Hepatitis B virus,Adenoviridae,Human alphaherpesvirus 1,Human T-cell leukemia virus type I,Coxsackievirus,Human adenovirus 5,Human adenovirus sp.,Human adenovirus 2,Human adenovirus E4,Human adenovirus 12,Human adenovirus D37,Human mastadenovirus C,Human adenovirus 52,Mus musculus,Rattus norvegicus,Homo sapiens)
• Representative miRNA-gene network interactions between the genes with an altered expression levels when comparing tumor to normal tissue and their respective miRNAs, generated using miRNet (2019, Homo sapiens)
• Interaction network showing miRNAs and their predicted and validated targets (2019, Helicobacter pylori)
• Differentially expressed genes associated with the p53 signaling pathway (2019, PX clade,Argopecten irradians)
• Prebiotics: Mechanisms and Preventive Effects in Allergy (2019, Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Bifidobacterium longum,Faecalibacterium prausnitzii,Akkermansia muciniphila,Lacticaseibacillus rhamnosus,Clostridioides difficile CD3,Bifidobacterium bifidum,Bifidobacterium breve,Bifidobacterium animalis subsp. lactis,Bifidobacterium pseudolongum,Clostridioides difficile CD44,Lachnospira eligens,Bifidobacterium bifidum NCIMB 41171,Saccharomyces cerevisiae,Zea mays,Diaporthe sclerotioides,Triticum aestivum,Hordeum vulgare,Malus domestica,Arachis hypogaea,Allium cepa,Allium sativum,Musa acuminata,Cichorium intybus,Cyamopsis tetragonoloba,Allium ampeloprasum,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,gut metagenome)
• Metabolite pathway analysis with Pearson correlation coefficient only edges corresponding to correlations whose similarity was less than 0.5 are shown (2019, NA)
• Adenosine Blockage in Tumor Microenvironment and Improvement of Cancer Immunotherapy (2019, Homo sapiens,Mus musculus)
• Immunopathology of Trichomoniasis (TV) (2019, Neisseria gonorrhoeae,Gardnerella vaginalis,Lactobacillus jensenii,Lactobacillus iners,Prevotella bivia,Fannyhessea vaginae,Megasphaera sp.,Leptotrichia sp.,Saccharomyces cerevisiae,Candida dubliniensis,Candida albicans,Nakaseomyces glabratus,Pichia kudriavzevii,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Trichomonas vaginalis,Tritrichomonas suis,Homo sapiens,cellular organisms,NA)
• Circadian regulation of hepatic gluconeogenesis illustrates an example of bi-directional regulation between clock genes and metabolism (2019, NA)
• miRNAs orchestrate T cell metabolic reprogramming (2019, Homo sapiens,Mus musculus)
• BC subtype-specific EV protein kinase networks (2019, NA)
• DEGs’ products protein-protein interaction network for each mineral (2019, NA)
• Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies (2019, Homo sapiens)
• Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies (2019, Homo sapiens)
• Adaptive response-mediated resistance to BRAF inhibitors in melanoma (2019, NA)
• MAPK signalling in the context of wild type BRAF and mutant BRAFV600E (2019, NA)
• Simplified model of fatty acid (FA) metabolism (2019, NA)
• Molecular mechanisms to increase glucose turnover in AML (2019, NA)
• Simplified scheme of the cellular metabolism pathways important for AML pathophysiology (2019, NA)
• Molecular interplay between estrogen, EGF, and Notch signaling pathways in FTEC ciliogenesis (2019, Homo sapiens,Bos taurus,Capra hircus,Papio anubis,Mus musculus,NA)
• Upstream regulators and signaling cascades linked to the hNgb protein interactors in a non-stress condition (2019, NA)
• Signaling pathways downstream urokinase-type plasminogen activator (uPA) receptor (uPAR) and its co-receptors (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Drugs developed against canonical WNT pathway components (2019, NA)
• Canonical WNT pathway components associated with disease (2019, NA)
• Canonical WNT pathway in on and off states (2019, NA)
• FoxO functions in cell response to antitumor drugs (2019, NA)
• Pathways of androgen action in the Sertoli cell (2019, NA)
• After interacting with CD154, CD40 recruits and interacts with several adapter proteins, including TRAF1, 2, 3, 5 and 6 (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Canis lupus familiaris,Diaporthe sclerotioides)
• Human oligodendrocyte precursor cells (hOPCs) incorporate and metabolize nervonic acid (2019, NA)
• Role of heat shock protein 27 (HSP27) in different cellular apoptotic processes (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Ceratitis capitata)
• LRP6 and WNT/Beta-catenin pathway alterations in epithelial cancers (2019, Nicotiana tabacum,Lareunionomyces loeiensis,Hepatitis B virus,Mouse mammary tumor virus,Homo sapiens,Mus musculus,Xenopus laevis,Helicobacter pylori)
• Canonical WNT signaling (2019, Nicotiana tabacum,Lareunionomyces loeiensis,Hepatitis B virus,Mouse mammary tumor virus,Homo sapiens,Mus musculus,Xenopus laevis,Helicobacter pylori)
• Direct and indirect epigenetic control of cellular metabolism (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sesamum indicum,Homo sapiens)
• The PI3K/Akt/mTOR signaling pathway (2019, Homo sapiens)
• Simplified overview of the MAPK and PI3K pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Human gammaherpesvirus 4)
• Glucose metabolism is highly crucial for cancer cells (2019, NA)
• Figure depicts pathways that cross-talk with Hh pathway leading to its non-canonical activation (2019, Homo sapiens,Mus musculus,Mouse mammary tumor virus,Paraechinus aethiopicus)
• Figure depicts canonical hedgehog signaling pathway (2019, Homo sapiens,Mus musculus,Mouse mammary tumor virus,Paraechinus aethiopicus)
• The regulation of Keratin 6, 16 and 17 during skin wounding and in psoriasis (2019, NA)
• TRPML1-3 and TPC1-2 in the endocytic pathway (2019, NA)
• Expanding High Mobility Group A1 (HMGA1) chromatin functions (2019, NA)
• BRAF-mediated signaling in normal and cancer cells (2019, NA)
• PTEN-mediated control of cancer stem cells (CSCs) hallmarks (2019, Homo sapiens)
• Protein functional interactome network for differentially expressed proteins identified in Pancreatic ductal adenocarcinoma (PDAC) tissue; down-regulated proteins (A) and up-regulated proteins (B) (2019, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Ca2+ toolkit in endothelial colony forming cells (ECFC) (2019, NA)
• Ca2+-dependent activation of the extracellular signal-regulated kinase (ERK) pathway and of the Nuclear Factor of Activated T-cells (NFAT) (2019, NA)
• Pro-angiogenic Ca2+ toolkit in vascular endothelial cells (2019, NA)
• Role of SUMOylation in the regulation of Tax oncoprotein of the human T-cell lymphotropic virus type I (HTLV1) virus (2019, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• SUMOylation regulates gene expression during Acute Myeloid Leukemia (AML) response to chemo- and differentiation therapies (2019, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• SUMO conjugation/deconjugation cycle (2019, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Upper, matrix metalloproteinase 1 (MMP1) cleavage of protease-activated receptors (PARs) result in increased Ca2+signaling (2019, NA)
• Intracellular signaling involved in cardioprotective response stimulated by ischemic postconditioning (PostC) in cardiac cells (2019, Arachis hypogaea,Polygonum cuspidatum,Ziziphus mauritiana,Oryctolagus cuniculus,Mustela putorius furo,Homo sapiens,Rattus norvegicus)
• Stress and depression drive an increase in corticotropin releasing factor (CRF) that activates mucosal mast cells and leads to an increase in gut permeability, coupled to gut dysbiosis and decreased butyrate production (2019, NA)
• Schematic of the signalling pathways involved in AVE 0991-attenuated pyroptosis and hepatocyte damage induced by heat stress by inhibiting the ROS-NLRP3 inflammatory signalling pathway (2019, NA)
• Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences (2019, Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Rattus norvegicus,Moloney murine leukemia virus)
• Analysis of potential roles of combinatorial microRNA regulation in occurrence of valvular heart disease with atrial fibrillation based on computational evidences (2019, Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Rattus norvegicus,Moloney murine leukemia virus)
• Assessment of network module identification across complex diseases (2019, NA)
• piRNA and KRAB-ZFPs: two host systems that recognize and silence TEs (2019, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Aedes aegypti,Dictyostelium discoideum,Acyrthosiphon pisum,Culex quinquefasciatus,Tetrahymena thermophila,Drosophila simulans,Drosophila yakuba,Oxytricha trifallax,Drosophila erecta,Drosophila biarmipes,Sterkiella histriomuscorum,DNA viruses,Dengue virus type 2,Semliki Forest virus,Murine leukemia virus,Human endogenous retroviruses,Avian leukosis virus,Human endogenous retrovirus K,Human endogenous retrovirus H,Gallus gallus,Danio rerio,Xenopus laevis,teleost fish,Xenopus tropicalis,Ambystoma mexicanum,Tetrapoda,Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Zea mays,Schizosaccharomyces pombe,Solanum melongena,Monodelphis domestica,Phascolarctos cinereus,Homo sapiens,Mus musculus,transposons)
• Local action of atrial natriuretic peptide (ANP) in cardiomyocytes (2019, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Nobiletin-induced apoptotic pathway in bladder cancer cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Leptailurus serval,Armoracia rusticana,Citrus reticulata,Hesperocyparis lusitanica,Mus musculus,Rattus norvegicus,Homo sapiens,Mycobacterium tuberculosis variant bovis BCG)
• RTT-related protein known functional interaction networks (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Microglial signaling pathways determining development of cells with divergent abilities (2019, NA)
• Role of IL-1 cytokine family members in the immunological history of the hepatocarcinoma (2019, NA)
• Several metabolic mechanisms may provide an advantage to Tregs in the tumor microenvironment (2019, Homo sapiens,Mus musculus,Candida dubliniensis)
• Classification of caspases (2019, NA)
• Mammalian target of rapamycin (mTOR) pathway (2019, Mycobacterium tuberculosis,Homo sapiens)
• Our proposed model of KRAS and TP53 oncogenes driving PDAC malignancy via the ARF6–AMAP1 pathway (2019, NA)
• Schematic overview of glycolysis and mitochondrial respiration (2019, Homo sapiens,Rattus norvegicus,Bos taurus,Gallus gallus,NA)
• MicroRNA regulation in colorectal cancer tissue and serum (2019, Homo sapiens,prion)
• MicroRNA regulation in colorectal cancer tissue and serum (2019, Homo sapiens,prion)
• Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• SUCO related genes involved in the cell cycle pathway (2019, Homo sapiens,Hepatitis B virus)
• Secretin receptor signaling in GnRH neurons (2019, NA)
• Mucosal innate immune responses to STIs in the female genital tract that could potentiate HIV transmission risk (2019, NA)
• Anti‐ and proviral roles of autophagy in plants (2019, NA)
• NLRP3 inflammasome activation pathway (2019, Mus musculus,Rattus norvegicus,Candida dubliniensis,Melia azedarach,Homo sapiens,Escherichia coli)
• Hedgehog (Hh) pathway (2019, NA)
• MST1 acts as a regulator of the extrinsic apoptotic pathway in Jurkat T cells (2019, NA)
• Adenovirus early region 3 RIDA protein limits NFKB signaling through stress-activated EGF receptors (2019, NA)
• Most potent small molecules capable of inhibiting Hh pathway with their mode of action (2019, Sar)
• Hedgehog signaling pathway (2019, Sar)
• Immunotherapies that target CAFs (2019, NA)
• DEGs involved in estrogen and prostaglandin signaling pathways (2019, NA)
• The role and proposed mechanism of Wnt5a in psoriatic arthritis (2019, NA)
• LPS/TLR4 signalling pathway (2019, NA)
• Schematic diagram showing the cardioprotective effects of YWPC on DOX‐induced cardiotoxicity (2019, Mus musculus,Rattus norvegicus,Oryza sativa,Triticum aestivum,Homo sapiens,Bos taurus)
• The mechanisms of total triterpenes of the E (2019, NA)
• Signal transduction pathways and transcriptional regulators affecting the filamentous growth of dimorphic pathopoiesis fungus in response to environmental conditions, which were reconstructed based on the predicted morphological shift in C (2019, NA)
• Central carbon metabolism of T (2019, NA)
• Current targets and therapies in PAH (2019, Homo sapiens)
• Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India (2019, Trypanosoma cruzi,Leishmania donovani,Plasmodium vivax,Leishmania infantum,Plasmodium knowlesi,Homo sapiens,Mus musculus,Dengue virus,Entomocorus benjamini)
• Bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Signalling pathway induced by ManLAM (2019, NA)
• Myofibroblasts were treated with curcumin (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Curcuma longa,Homo sapiens,Carassius auratus)
• Schemes for nanoparticles loaded with specific agents to target TAM signaling pathways (2019, NA)
• The TGF-ß/Smad signalling pathway and the possible targets of tamoxifen (TAM) and rBMP7 to prevent PF development (2019, NA)
• Vascular inflammation during tumor cell extravasation and metastasis (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Nicotiana tabacum,NA)
• Hypothetic model of OME on colon cancer cells (2019, Origanum majorana,Homo sapiens)
• Linc00152 promotes the proliferation of gastric cancer cells by regulating the PI3K/AKT signaling pathway (2019, NA)
• Linc00152 promotes the proliferation of HCC cells by activating the mTOR signaling pathway (2019, NA)
• Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy (2019, NA)
• Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy (2019, NA)
• Mitochondrial NAD+/NADH Redox State and Diabetic Cardiomyopathy (2019, NA)
• Subnetworks of special pathogenic pathways corresponded to different metastasis lesions (2019, NA)
• Mitochondria and neurotrophic hypothesis in MDD pathophysiology (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Overlapping molecular mechanisms involved in the onset and progression of DM and AD that can be modulated by the specific action of phenolic compounds (2019, NA)
• Schematic depicting the role of the C/EBP-Beta-lcn2 signaling pathway in MA-induced microglial apoptosis (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Filovirus replication cycle showing host and viral proteins that either promote (green boxes) or block (red boxes) virion assembly and release (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Ebola virus,Chikungunya virus,Murine leukemia virus,SARS coronavirus NS-1,Influenza B virus,Zaire ebolavirus,Chimpanzee adenovirus,Human spumaretrovirus,Bombali ebolavirus,Sudan ebolavirus,Tai Forest ebolavirus,Bundibugyo ebolavirus,Reston ebolavirus,Mus musculus,Cricetulus griseus,Homo sapiens,NA,NA,NA,NA)
• Differential Transcriptome Responses to Aflatoxin B1 in the Cecal Tonsil of Susceptible and Resistant Turkeys (2019, NA)
• An overview of Wnt signaling pathway (2019, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Clostridioides difficile,Mycobacterium tuberculosis variant bovis BCG,Shigella flexneri,Citrobacter rodentium,Salmonella enterica subsp. enterica serovar Enteritidis,Ehrlichia chaffeensis,Lawsonia intracellularis,Gallus gallus,Danio rerio,Dipnomorpha,Homo sapiens,Mus musculus,Drosophila melanogaster,Sus scrofa,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Molecular mechanism of miR-134 involvement in ESCC tumorigenesis (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Danio rerio,Armoracia rusticana)
• Physiological and pathological hypertrophy (2019, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified,NA)
• In response to various stimuli such as infection or injury, mucosal epithelial barriers express a range of signals that ILC2s can integrate (2019, Nippostrongylus brasiliensis,Schistosoma haematobium,Heligmosomoides polygyrus,Trichuris muris,Onchocerca volvulus,Wuchereria bancrofti,Trichuris trichiura,Loa loa,Human gammaherpesvirus 4,Fowlpox virus,Homo sapiens,Mus musculus)
• Schematic diagram of CB2R mediated signaling (2019, NA)
• Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• KRT19 and Wnt/beta-catenin/Notch signaling pathway in colon and breast cancers (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Meleagris gallopavo)
• CNVs, SNVs/indels on histamine‐related metabolism and signalling pathways (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster,Vasconcellea candicans,Merluccius merluccius)
• Closer Look at Pyroptosis (2019, NA)
• The main enzyme pathways involved in mitochondrial pyrimidine dNTPs metabolism (2019, NA)
• Deoxynucleotide salvage and de novo synthesis pathways (2019, Homo sapiens,Mus musculus,Escherichia coli,Oryctolagus cuniculus,Diaporthe sclerotioides)
• Proposed model of dovitinib-mediated autophagy and apoptosis with regard to the SHP-1/p-STAT3 pathway in breast cells (2019, NA)
• Ang/Tie2 signalling in the diabetic eye, including crosstalk with the VEGF pathway (2019, NA)
• Schematic KEGG map representations of signaling pathways involved in Alzheimer's disease (a), Parkinson's disease (b), and amyotrophic lateral sclerosis (c) (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Heterocephalus glaber,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Nicotiana tabacum,Homo sapiens,Bos taurus)
• Kinetochore PP2A-B56 and PP1 promote the stability of microtubule attachments and efficient Spindle Assembly Checkpoint silencing in animal cells (2019, NA)
• JAK/STAT pathway is involved in the miR155/SOCS1 axis in the immune system (2019, Citrobacter rodentium,Francisella tularensis,Francisella tularensis subsp. novicida,Homo sapiens,Mus musculus,Reticuloendotheliosis virus)
• Proposed pathway explaining some biochemical effects, induced in vitro by PBDEs, on cell cycle, antioxidant status, metabolism and proliferation (2019, NA)
• Role of the NFKB pathway in the miR-155/SOCS1 axis in the immune system (2019, Citrobacter rodentium,Francisella tularensis,Francisella tularensis subsp. novicida,Homo sapiens,Mus musculus,Reticuloendotheliosis virus)
• Apoptosis pathway and potential targets for pharmacological modulation (2019, NA)
• Illustration of a putative additional molecular mechanism for the ability of the inhibitory T cell signaling proteins CTLA-4 and PD-1 and the GPCR A2AR to diminish T cell activation leading to the enhancement of cancer development (2019, Homo sapiens)
• Microglial inflammatory responses by IFNB signaling (2019, Mus musculus,Rattus norvegicus,Plantago princeps,Prenanthella exigua,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus 1)
• Before binding by a Hedgehog family ligand (most often Shh, but also Ihh or Dhh), Ptch1 and presumably Ptch2 maintain Smo sequestered, by a currently unknown mechanism (2019, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Drosophila melanogaster,Nematostella vectensis,Eumetazoa,Mus musculus,Rattus norvegicus,Homo sapiens,Paraechinus aethiopicus,Veratrum californicum,NA)
• Hepatocellular carcinoma development in the Mat1a knockout mouse (2019, NA)
• Mechanism of response mediated by M1, M2, and M4 macrophages (2019, NA)
• Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic Beta-Cells to Type 2 Diabetes (2019, NA)
• Interactions between VHL, HIF and the NFKB signaling pathway (2019, Homo sapiens,Mus musculus)
• LRRFIP1/GCF2 binds to exogenous and endogenous nucleic acids and activates type 1 interferon and pro-inflammatory cytokine responses (2019, NA)
• Enriched immunological pathway and genes (2019, Homo sapiens)
• HMGB1-RAGE/TLR-TNFA signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers (2019, Saccharomyces cerevisiae,Diaporthe sclerotioides,Ipomoea batatas,Sesamum indicum,Ganoderma lucidum,Nigella sativa,Piper longum,Cyclocarya paliurus,Bixa orellana,Syzygium cumini,Rosa roxburghii,Physalis peruviana,Rumex crispus,Catathelasma ventricosum,Neopicrorhiza scrophulariiflora,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Bifidobacterium longum,Lambis lambis)
• Structural hotspots and signaling pathways that are essential to the hepatic phenotype of highly differentiated HepaRG cells (2019, Bos taurus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Mus musculus,Escherichia coli,unidentified,Venustaconcha ellipsiformis)
• SDF-1 induces angiogenesis-related signaling pathways in HUVECs co-cultured with SMMC-7721 hepatocellular carcinoma cells (A) (2019, Homo sapiens,Taraxacum officinale)
• Cell death pathways induced by gef/apoptin (2019, Escherichia coli,Clostridium perfringens,Bacillus thuringiensis,Plasmid R1,Plasmid R483,Human alphaherpesvirus 1,Avian myeloblastosis virus,Infectious pancreatic necrosis virus,Chicken anemia virus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Insulin signaling regulates neuronal function (2019, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Oryctolagus cuniculus,Canis lupus familiaris,Olea europaea,Urtica dioica,Homo sapiens)
• Putative model of positive and negative loops in the regulation of CREB-1 and CREB-2 expression and likely pathways by which Olibanum could control these loops (2019, NA)
• Identification of unique pathways after treatment with SC-3–141 (2019, Sequoia sempervirens,Psidium guajava,Homo sapiens,Rattus norvegicus,Bos taurus)
• AvB5 integrin/FAK-mediated phagocytic pathway in TM-1 cells (2019, NA)
• Crosstalk between the Rho kinase and BMP-2 signaling pathways (2019, NA)
• System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells (2019, NA)
• Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study (2019, Homo sapiens,prion,Propionibacterium freudenreichii)
• Proteome-transcriptome alignment of molecular portraits achieved by self-contained gene set analysis: Consensus colon cancer subtypes case study (2019, Homo sapiens,prion,Propionibacterium freudenreichii)
• Biomarkers in the Pathways in cancer (2019, Homo sapiens)
• MiRNAs involve in different types of cancers and colorectal cancer biomarkers (2019, Homo sapiens)
• Rapamycin pathwa, cell cycle and autophagy in cancer and Alzheimer’s disease (2019, NA)
• Role of Itch in Type I non-canonical Hh pathway (2019, NA)
• Analysis of human inner ear transcriptome over-layed on a generic human neurotrophin signaling pathway (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Felis catus)
• Proposed model for MAPK inhibition in paired TP53WT and TP53MUT cell lines selected for resistance to MDM2 inhibitors (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Nongenomic and Genomic actions of Thyroid hormone and thyroid hormone receptor (2019, NA)
• Autophagy pathway and potential targets for pharmacological modulation (2019, NA)
• Schema of miR-451 regulated YWHAZ pathway (2019, Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Working model (2019, NA)
• Protection for oral SUB+IV vaccine against tick infestations in cattle (2019, Rhipicephalus microplus,Homo sapiens)
• Cartoon picture represents the mechanisms of inhibition of in-vitro metastatic potential after single and combined treatment (2019, NA)
• Signaling pathways for CSF-1 and FAK (2019, NA)
• Gene category of the NFKB signaling pathway (2019, Homo sapiens,Oryctolagus cuniculus,Helicobacter pylori,Human T-cell leukemia virus type I)
• Proposed model of the combined effect of ROR1 inhibition and erlotinib treatment in non-small cell lung cancer cell lines via inhibition of the AKT/mTOR signaling pathway (2019, NA)
• The cooperation between M and P proteins to inhibit different Jak-Stat-pathway steps (2019, Influenza A virus,unidentified influenza virus,Dengue virus,Vesicular stomatitis virus,Vaccinia virus,Measles morbillivirus,Lyssavirus rabies,Polyomavirus sp.,Human orthopneumovirus,Borna disease virus,Bovine orthopneumovirus,Dengue virus type 3,Lyssavirus mokola,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Mus musculus,Gallus gallus,Armoracia rusticana,NA)
• Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma (2019, NA)
• Ca2+signaling pathways in Beta-cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Estradiol signaling (2019, NA)
• Schema of miR-19a-3p regulated Fra-1 gene pathway (2019, Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Proposed model by which polyphenols may modulate oxidative stress-induced pathways including Ang II, VEGF and TNFA (2019, Saccharomyces cerevisiae,Solanum tuberosum,Malus domestica,Olea europaea,Curcuma longa,Camellia sinensis,Fragaria x ananassa,Punica granatum,Thymus vulgaris,Vaccinium myrtillus,Hippophae rhamnoides,Rubus occidentalis,Vaccinium corymbosum,Euterpe oleracea,Malus pumila,Passiflora tarminiana,Mus musculus,Rattus norvegicus,Mesocricetus auratus,Homo sapiens,Bos taurus)
• Selected enriched KEGG pathways among DETs between S41 and S43 during tail resorption (2019, NA)
• Proposed mechanism of LAMB3-mediated tumor antiapoptotic signaling, invasion and metastasis through the PI3K/Akt axis in patients with pancreatic ductal adenocarcinoma (PDAC) (2019, Homo sapiens,Mus musculus,Bos taurus)
• Proposed schematic diagram of RLIP76 role in angiogenesis (2019, NA)
• Schematic picture of the type I interferon production and different nucleic acid sensors (2019, NA)
• Inducers and regulators of IFNA production by plasmacytoid dendritic cell (2019, NA)
• Interferon receptors and signalling (2019, NA)
• The NFE2L2 pathway in fibroblasts (2019, NA)
• Summary of the role of the ERK1/2signaling pathway in CIRI (2019, NA)
• Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma (2019, NA)
• Summary of the functions of the ERK1/2signaling pathway (2019, NA)
• State of art of neutrophil extracellular traps in protozoan and helminthic infections (2019, Trypanosoma cruzi,Entamoeba histolytica,Neospora caninum,Eimeria bovis,Homo sapiens)
• Summary of the classical Ras-Raf-MEK-ERK1/2signaling pathway (2019, NA)
• Muscle Wasting Diseases: Novel Targets and Treatments (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Adeno-associated virus,Bikinia letestui)
• Pathways participate in tumourigenesis of CCA (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Clonorchis sinensis,Opisthorchis viverrini,Cyathopoma iota,Homo sapiens,Pleistophora sp. 1)
• B‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 R239X mice (2019, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Matthiola incana,Bikinia letestui,Vasconcellea candicans,Danio rerio,Opsanus beta,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Arachidonic acid pathway (left panel) with associated impact of aspirin/non-steroidal anti-inflammatory disease (NSAID) therapy and inhibition (right panel) (2019, Homo sapiens,Mus musculus)
• Biological processes associated with up-regulated genes after cecal ligation and puncture and back-regulated by landiolol infusion (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Theilers encephalomyelitis virus,Derris trifoliata)
• Different stages of erythropoiesis and regulatory processes (including cytokines, transcription factors and related signal transduction proteins) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• KEGG pathway analysis for HepG2 cells depicting the upregulated genes in the TNF signaling pathway after the treatment with TIT3; the altered genes are marked (2019, Diaporthe sclerotioides,Lessertia frutescens,Homo sapiens,Mus musculus,Bos taurus,Hepatitis B virus,NA)
• Transforming growth factor-Beta- (TGF-Beta-) induced EndoMT (2019, NA)
• GTS-21 has cell-specific anti-inflammatory effects independent of A7 nicotinic acetylcholine receptors (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Xenopus laevis)
• Circadian clock pathway mapped with relative expression levels (T1 vs (2019, Arabidopsis thaliana,Zea mays,Solanum lycopersicum,Solanum tuberosum,Triticum aestivum,Cucumis sativus,Fragaria x ananassa,Cicer arietinum,Manihot esculenta,Fragaria vesca,Citrus trifoliata,Fragaria vesca subsp. americana,Homo sapiens)
• IH protection against liver fibrosis (2019, NA)
• Signaling pathways in mDA neuron development (2019, Homo sapiens,Mouse mammary tumor virus)
• Mechanisms promoting macrophage phagocytosis of AC by lipid mediators (2019, NA)
• In vivo induction of demyelination by direct Mycobacterium leprae injection into sciatic nerves (2019, NA)
• Interaction between the TGFB signaling pathway and HCV core protein (2019, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Merkel cell polyomavirus,Human T-cell lymphotropic virus,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Cystobasidium portillonense,Homo sapiens,NA)
• Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells (2019, Homo sapiens,Mus musculus,Vasconcellea candicans)
• Inflammatory pathway centered upon TNF in the process of NASH-HCC development (2019, gut metagenome,metagenome,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli)
• Intrinsic intracellular signaling cascades of BDNF-TrkB and TrkB-A2a receptors (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Diaporthe sclerotioides)
• Sphingolipid metabolic pathway (2019, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Measles morbillivirus,Homo sapiens,Danio rerio,Antarctothoa delta,NA)
• Dual sequential cell death checkpoints in the TNFR1 signaling pathway (2019, Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG)
• RAS/ERK, PI3K/AKT, WNT and Beta-catenin signaling pathways are involved in different stages of brain development and are commonly disrupted in ASD (2019, Homo sapiens,Mus musculus)
• Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets (2019, NA)
• Facets of Theiler’s Murine Encephalomyelitis Virus-Induced Diseases: An Update (2019, NA)
• Alterations of the PI3K/Akt-Cyclin D1 pathway in cell cycle progression from G1 to S phase in 2-cell embryos (2019, Bixa orellana,Homo sapiens)
• Signaling pathway of the AR (2019, NA)
• Interaction between VEGF signaling pathway and HCV core protein (2019, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Merkel cell polyomavirus,Human T-cell lymphotropic virus,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Cystobasidium portillonense,Homo sapiens,NA)
• The Function and Therapeutic Potential of Epstein-Barr Virus-Encoded MicroRNAs in Cancer (2019, NA)
• Proposed molecular mechanism of regulation of the pyrin inflammasome (2019, NA)
• Translesion synthesis (2019, Saccharomyces cerevisiae,Nicotiana tabacum,Schizosaccharomyces pombe,Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• Regulating mechanisms of UCA1 in multiple human cancers (2019, Homo sapiens,Mus musculus,Human endogenous retrovirus H)
• p38MAPK signalling cascade (2019, NA)
• A glucagon-like peptide-1 analog, liraglutide, ameliorates endothelial dysfunction through miRNAs to inhibit apoptosis in rats (2019, NA)
• DEGs clustered in the PPAR signaling pathway (2019, NA)
• Wnt signaling: a promising target for osteoarthritis therapy (2019, Lareunionomyces loeiensis,Cullen corylifolium,Ligustrum lucidum,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Wnt signaling: a promising target for osteoarthritis therapy (2019, Lareunionomyces loeiensis,Cullen corylifolium,Ligustrum lucidum,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Manipulation of Glucose and Hydroperoxide Metabolism to Improve Radiation Response (2019, NA)
• Wnt signaling: a promising target for osteoarthritis therapy (2019, Lareunionomyces loeiensis,Cullen corylifolium,Ligustrum lucidum,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• PI3K pathway inhibitors target one or more aspects of PI3K signaling (2019, Homo sapiens,Mus musculus)
• An illustration of the bidirectional interaction between Th17 and BEC (2019, Homo sapiens)
• Putative signalling pathway of Ctyl1 (2019, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Nicotiana tabacum)
• Main molecular interactions implemented in the model (2019, NA)
• miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGFB Signaling (2019, Homo sapiens,Mus musculus,Bos taurus,Treponema medium)
• Interaction between Wnt/Beta-catenin signaling pathway and HCV core protein (2019, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Merkel cell polyomavirus,Human T-cell lymphotropic virus,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Cystobasidium portillonense,Homo sapiens,NA)
• Graphical model of IL-1B activation of signaling pathways leading to acquisition of resistance to cisplatin in breast cancer cells (2019, NA)
• Estrogen signaling pathways in cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Tyrosine kinases in the development of atopic dermatitis (2019, NA)
• ASD gene networks constructed with PASCAL associated genes and its FunCoup interactors (2019, NA)
• Autophagy and VEGF signaling (2019, Mus musculus,Armoracia rusticana,Cavia porcellus,Linum usitatissimum,Homo sapiens)
• Schematic diagram depicting possible mechanisms involved in the anti-fibrotic effect of melatonin and PAA (2019, NA)
• Scheme summarizing the protection of AB25–35-induced SH-SY5Y cell mitochondrial dysfunction by ginsenoside Re via inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response pathway (2019, NA)
• Simplified MAPK signaling pathways (2019, Drosophila melanogaster,Trypanosoma cruzi,Toxoplasma gondii,Leishmania donovani,Schistosoma mansoni,Leishmania amazonensis,Clonorchis sinensis,Echinococcus multilocularis,Echinococcus granulosus,Homo sapiens,Mus musculus,Cystobasidium portillonense)
• Autophagy Intertwines with Different Diseases (2019, Human immunodeficiency virus 1,Human immunodeficiency virus,West Nile virus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,prion)
• Signaling pathway for GSSA via SCARB1 receptor from CD19+ lymphocyte (2019, NA)
• Proposed targeting approaches involving ACSL isoenzymes in cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Ananas comosus,Lactobacillus gasseri)
• Crucial role of Wnt/Beta-catenin signaling pathway in multiple steps of bone sarcoma progression and metastatic dissemination (2019, NA)
• Canonical Wnt/Beta-catenin signaling pathway (2019, NA)
• Regulation of autophagy by ROS (2019, NA)
• DNAM-1 signaling pathway leading to natural killer (NK) cell activation (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Enterovirus C,Human alphaherpesvirus 2,Chikungunya virus,Human immunodeficiency virus 2,Suid alphaherpesvirus 1,Aurantiochytrium single-stranded RNA virus 01,Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus,Pseudomonas phage PRR1,NA,NA)
• VPA affects IL-12-, IL-15-, and IL-18-mediated IFNG production in NK cells (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• Transcriptional co-ordination between YAP1/Hippo and p53 family proteins in tumorigenesis or apoptosis (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Toll-like receptor (TLR) signaling (2019, Escherichia coli,Staphylococcus aureus,Streptococcus pyogenes,Streptococcus agalactiae,Gardnerella vaginalis,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Candida albicans,Influenza A virus,Zika virus,Candida albicans 11C,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Bos taurus,NA)
• Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC) (2019, NA)
• EGFR pathway regulates PD-L1 expression in NSCLC (2019, NA)
• Epidermal growth factor receptor (EGFR) pathway in non-small cell lung cancer (NSCLC) (2019, NA)
• GRA/PPARA controlled points of interference with the TNF signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Graphical summary: the metabolic reprogramming during macrophage polarization induced by M-CSF (M2) and reinforced by IL-10 (M2c) leads to P2Y11 receptor upregulation (2019, NA)
• The effect of P (2019, Pseudomonas aeruginosa,Homo sapiens)
• rLj-112 was internalized with EGFR to suppress the downstream signaling pathways to initiate the anti-tumor steps in B16 cells (2019, NA)
• Physiopathology of JCPyV in the brain (2019, NA)
• Renin-angiotensin system and its bypass loops and converging signaling pathways can be targeted at different points (2019, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Sub-network of SNHG12 (2019, NA)
• P53 signaling pathway (hsa04115) is extended in the weighted network (2019, Homo sapiens,Mus musculus)
• Transcriptome analysis of the molecular mechanism underlying immunity- and reproduction trade-off in Locusta migratoria infected by Micrococcus luteus (2019, Micrococcus luteus,Locusta migratoria)
• The role of CXXC5 and molecular mechanism of KY19382 in longitudinal bone growth (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Homo sapiens,unidentified)
• Icaritin induced apoptosis through multiple and differential signaling pathways (2019, NA)
• Thiamine metabolism (2019, Oryza sativa,Theobroma cacao,Ziziphus mauritiana,Equisetum arvense,Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome,Phoca vitulina)
• Basic schematic representation of the cAMP-PKA pathway (green) and three MAPK pathways in Candida albicans which are important for morphogenesis, adaptation to stress and survival (2019, NA)
• Interaction between the PPARA signaling pathway and HCV core protein (2019, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Merkel cell polyomavirus,Human T-cell lymphotropic virus,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Cystobasidium portillonense,Homo sapiens,NA)
• Assessment of in vivo genotoxicity of citrated-coated silver nanoparticles via transcriptomic analysis of rabbit liver tissue (2019, Oncorhynchus mykiss,Calloplesiops altivelis,Ctenopharyngodon idella,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Daphnia magna)
• Transcriptional coverage of penguin transcripts within the vertebrate nuclear factor kappa B (NFKB) signaling pathway (#04064) (2019, NA)
• Transcriptional coverage of penguin transcripts on the vertebrate Janus kinase/signal transducers and activators of transcription (JAK-STAT) (#04630) (A) and vertebrate Toll-like receptor (TLR) signaling pathway (#04620) (B) (2019, NA)
• TLR-7/-8 signaling in dendritic cells (2019, NA)
• Th17 cells produce a pro‐osteoclastogenic effect (2019, Bacteroides fragilis,Homo sapiens)
• Sodium and potassium loci in behavior, thermoregulation, and weight loss networks (2019, NA)
• Signaling pathway of CCR5 and neuronal plasticity (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Curcuma longa)
• Pathways for Nuclear factor K B (NFKB) signaling in the cytoplasm and the mitochondrion (2019, NA)
• Control of fruit biochemical composition (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Solanum tuberosum,Magnoliopsida,Helianthus annuus,eudicotyledons,Prunus persica,Musa acuminata,Capsicum annuum,Manihot esculenta,Solanum melongena,Fusarium oxysporum,Citrus sinensis,Phytophthora infestans,Petunia x hybrida,Capsicum frutescens,Atropa belladonna,Solanum aethiopicum,Ochroma pyramidale,Mandragora officinarum,Prunus persica f. duplex,Drosophila melanogaster,Venustaconcha ellipsiformis,Meloidogyne incognita,Globodera pallida,Globodera rostochiensis,Cauliflower mosaic virus,Tobacco mosaic virus,Potato virus X,Potato virus Y,Pseudomonas syringae,Xanthomonas campestris,Homo sapiens)
• Models of replication-coupled ICL repair (2019, Escherichia coli,Gallus gallus,Xenopus laevis,Escherichia coli FBH1,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Lambdavirus lambda)
• Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21WAF1/CIP1 and p27KIP1 in Cancer Cells (2019, NA)
• CD40 signalling pathway (2019, NA)
• EV production procedure.Exosomes, 50–150 nm, are initially formed by a process of inward budding in early endosomes to form multivesicular bodies (2019, NA)
• Differentially expressed genes involved in cell cycle pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Impact of ovarian cancer-exosomes on target cells during pre-metastatic niche formation (2019, NA)
• TSP-1-CD36 signaling induces apoptosis of tumor-associated endothelial cells (2019, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Plasmodium falciparum,Homo sapiens,Candida dubliniensis,NA)
• Schematic model for the positive feedback loop between fibroblast activation and ECM deposition mediated by CD44-RhoA-YAP signaling pathway (2019, NA)
• Schematic drawing showing the role of MRP4 in regulation of Wnt/Beta-catenin signaling in the endometrium (2019, NA)
• Cell apoptosis under ER stress (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Bikinia letestui)
• Proposed pathophysiological mechanisms that could explain the presence or absence of response to treatment in myocarditis (2019, Coxsackievirus B3,Coxsackievirus,Human parvovirus B19,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Endothelial theory (2019, NA)
• Platelet Theory (2019, NA)
• Drug screening of the lysosomal pathway by the lysosomal-METRIQ probe (2019, NA)
• Telomere length maintenance mechanisms (2019, NA)
• Pathway analysis for PRR and IFN signaling (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Dengue virus,Zika virus,West Nile virus,Japanese encephalitis virus,Ebola virus sp.,Yellow fever virus,Borna disease virus,Reticuloendotheliosis virus,Mus musculus,Candida dubliniensis,Cavia porcellus,Sequoia sempervirens,Homo sapiens,Aedes aegypti,NA,NA)
• Apoptosis induced by Endoplasmic Reticulum (ER) stress (2019, NA)
• Hypoxia-Induced Autophagy Degrades Stromal Lumican into Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma: A Mini-Review (2019, Homo sapiens,Mus musculus)
• Schematic diagram showing the protective mechanism of DPHC on PM2.5-induced skin damage (2019, NA)
• Induced glutathione and reduced beta-alanine metabolism during IS sensing and signaling in response to oxidative stress (2019, Mus musculus,Rattus norvegicus,Zea mays,Avena sativa,Homo sapiens,Bos taurus,gut metagenome,Lacticaseibacillus paracasei)
• Autophagy in the differentiation/function of osteoclast, osteoblast and osteocyte (2019, NA)
• Cartoon representing the osteolytic and osteosclerotic vicious cycles (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Mouse mammary tumor virus)
• ANAC044/ANAC085-mediated pathway involved in stress-induced G2 arrest (2019, Drosophila melanogaster,Arabidopsis thaliana,Zea mays,Anavitrinella pampinaria,Homo sapiens,Oryctolagus cuniculus,Dipturus trachyderma,Agrobacterium tumefaciens)
• MicroRNAs regulate the smoking‐related ERBB2 signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Biosynthesis of isoprenoids in X (2019, NA)
• BTLA-associated signaling pathways (stimulatory/inhibitory) regulate the outcomes of HBV-ACLF, liver graft tolerance/rejection, liver cirrhosis and hepatocellular carcinoma (2019, Human immunodeficiency virus 1,Hepatitis B virus,Human alphaherpesvirus 1,unidentified influenza virus,Vaccinia virus,Murine hepatitis virus,Murine hepatitis virus strain 3,Homo sapiens,Mus musculus,Strongyloides stercoralis,NA)
• (A1) GPCRs induce GAq dependent c-Src activation at the plasma membrane and tyrosine phosphorylation of NEDD4-2, releasing NEDD4-2 auto-inhibition (2019, Homo sapiens,Mus musculus)
• Summary of genes involved in the glycolate production pathway (2019, NA)
• Differential pathway regulation in advanced idiopathic pulmonary fibrosis (IPF) lung (2019, Homo sapiens,Mus musculus,Byrsonima crassifolia)
• Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNFA Pathway and Reactive Oxygen Species Accumulation (2019, NA)
• Screening and Risk Assessment of Coronary Artery Disease in Patients With Type 2 Diabetes: An Updated Review (2019, Homo sapiens)
• Insulin signaling pathway (2019, NA)
• Dropwort extract exerts broad anticancer effects on MPM cells affecting cell proliferation, viability, migration, metabolism and in vivo tumor growth of MPM cell lines (2019, Armoracia rusticana,Psidium guajava,Cynara cardunculus,Cynara cardunculus var. scolymus,Filipendula vulgaris,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Calloplesiops altivelis)
• Microbial-based production of nutraceuticals from simple carbon sources (2019, Escherichia coli,Bacillus subtilis,Escherichia coli DH5alpha,Corynebacterium glutamicum,Enterococcus faecalis,Bacillus subtilis At2,Escherichia coli BL21,Escherichia coli BW25113,Rhodobacter capsulatus,Levilactobacillus brevis,Corynebacterium glutamicum ATCC 13032,Escherichia coli str. K-12 substr. W3110,Pantoea agglomerans,Pantoea ananatis,Escherichia coli ATCC 8739,Herpetosiphon aurantiacus,Agrobacterium aurantiacum,Brevundimonas vesicularis,Paracoccus sp. N81106,Saccharomyces cerevisiae,Arabidopsis thaliana,Diaporthe sclerotioides,Malus domestica,Vitis vinifera,Catharanthus roseus,Yarrowia lipolytica,Pichia kudriavzevii,Mucor circinelloides,Astragalus mongholicus,Blakeslea trispora,Taxus x media,Rhodotorula kratochvilovae,Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta,synthetic construct,Anthonomus grandis)
• Autophagy-A highly conservative cascaded regulatory mechanism upholds the intracellular homeostasis of the biological system (2019, Human immunodeficiency virus 1,Human immunodeficiency virus,West Nile virus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,prion)
• Signal transduction pathways that mediate migration induced by OA in breast cancer cells (2019, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Candida dubliniensis,Homo sapiens,Mus musculus)
• A proposed model of tau hyperphosphorylation under the conditions of normal and impaired insulin signaling (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Matthiola incana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Rg3 inhibits cell proliferation and induces apoptosis via different effector molecules and pathways, in MDA-MB-231 cell line (2019, NA)
• Key intrinsic immune evasion mechanisms exploited by HPV oncoproteins in keratinocytes (KCs) (2019, Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Vaccinia virus,Human papillomavirus types,human papillomavirus 11,Human papillomavirus 5,Human papillomavirus 38,Homo sapiens,Mus musculus)
• Hepatic metabolism of lipid and carbohydrate through insulin induced transcriptional regulation and circadian clock (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Extrinsic and intrinsic pathways of apoptosis (2019, Oryza sativa,Bixa orellana,Goniothalamus lanceolatus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Biosynthetic pathways for phosphatidic acid production (2019, NA)
• IRE1Alpha-XBP1 pathway of the UPR in CF (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Staphylococcus aureus,Pseudomonas aeruginosa,Homo sapiens,Vasconcellea candicans)
• The TORC1–PKA signaling circuit (2019, NA)
• Natriuretic peptide signaling in adipose tissue (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Elephas maximus)
• Proteoglycans in cancer-predicted pathway (2019, NA)
• CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3 (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Armoracia rusticana,Homo sapiens)
• Hypothetical scheme of the kefir peptides regulatory pathway (2019, NA)
• Epinephrine-induced PGE2 reduces Na+/K+ ATPase activity in Caco-2 cells via PKC, NFKB and NO (2019, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Vitamins on Alzheimer’s disease (2019, NA)
• Diagrammatic sketch of the working hypothesis (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Involvement of KRAS in cell survival and growth as well as in tumor microenvironment through MEK→ERK and PI3K signaling pathways (2019, NA)
• PG biosynthesis, receptors and signalling pathways (2019, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Helicobacter hepaticus,Homo sapiens,clinical samples)
• Lymphocyte‐mediated chronic inflammatory responses (2019, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Helicobacter hepaticus,Homo sapiens,clinical samples)
• Molecular mechanisms for PGE2‐cytokine crosstalk in facilitation of adaptive Th1 and Th17 cell responses (2019, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Helicobacter hepaticus,Homo sapiens,clinical samples)
• lncRNAs mediate drug and radiation resistance (2019, Homo sapiens,Mus musculus)
• Multi-loop model of AD: an integrated perspective on the Wnt/GSK3B, Alpha-synuclein, and type 3 diabetes hypotheses (2019, NA)
• Dysfunctions in canonical Wnt-Signaling contribute to the neuropathology of Alzheimer disease (AD) (2019, NA)
• Molecular characterization of subpathway signatures (2019, Homo sapiens)
• Kaposi Sarcoma (2019, NA)
• Kaposi Sarcoma (2019, NA)
• Wnt/Beta-cat signaling pathway (2019, NA)
• Intrinsic pathway (2019, Homo sapiens,Mus musculus)
• Translational challenges with systemic and local cell delivery (2019, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Diaporthe sclerotioides,Human betaherpesvirus 5)
• Regulation of C/EBPB in MDSCs (2019, Homo sapiens,Mus musculus)
• Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma (2019, NA)
• Suggested model of brassinosteroid (BR) regulation of immunity at multiple levels (2019, NA)
• Canonical pathway for A2B1 signaling (2019, NA)
• Metabolic reprogramming of T cells after allogeneic stem cell transplantation (2019, NA)
• Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Escherichia coli,clinical samples)
• Gold nanoparticles-loaded hydroxyapatite composites guide osteogenic differentiation of human mesenchymal stem cells through Wnt/Beta-catenin signaling pathway (2019, NA)
• Oxygen- and hydroxylase-dependent mechanisms regulating hypoxia-inducible factor 1 (HIF-1) activity (2019, NA)
• Schematic model of Dex-SPIONs protect HUVECs from H2O2 damage via inducing autophagy response (2019, NA)
• Interplay between shrimp NFKB pathways and WSSV (2019, NA)
• Comparison of the shrimp IMD pathways (A) and Drosophila IMD pathways (B) and Human TNFR signaling (C) (2019, NA)
• The mechanism of Notch1 signaling and CXCL12/CXCR4 axis in GICs self-renewal, invasion and tumor growth (2019, NA)
• Mechanism map depicting the molecular mechanism of BMP2 in HCC (2019, NA)
• Molecular landscape of SCLC (2019, Homo sapiens,Nicotiana tabacum,NA)
• Cyclin D1-CDK4/6-RB pathway and crosstalk in breast cancer (2019, Homo sapiens,Mus musculus)
• Representation of the various selenium metabolic pathways leading to selenoprotein synthesis (2019, NA)
• LncRNAs regulate angiogenesis through modulating multiple signaling pathways (2019, NA)
• Autophagy signaling in HCC (2019, NA)
• Natural plant compounds and epithelial-to-mesenchymal transition (2019, Celastrus orbiculatus)
• Molecular consequences of the PrPC/AB interaction in AD (2019, NA)
• HIF-1-dependent reprogramming of the glucose metabolic pathway, and resultant radioresistance (2019, NA)
• KLF5-targeted genes in the pancreatic cancer pathway (2019, NA)
• Schematic mechanism of apoptosis in ovarian cancer and some current targeted molecular therapeutic approaches (2019, NA)
• Putative pathway and analysis schematic diagram of glucose repression in K (2019, NA)
• UVB-induced ROS production followed by the activation of both JNK and p38 MAPK subfamilies, leading to apoptosis and photoaging on fibroblasts (red arrows) (2019, NA)
• Pharmacokinetic and pharmacodynamics pathways for mycophenolate mofetil (2019, NA)
• Reconstruction of insect hormone pathways in an aquatic firefly, Sclerotia aquatilis (Coleoptera: Lampyridae), using RNA-seq (2019, Sclerotia aquatilis,Homo sapiens)
• Signal pathway simulation of OPG regulating proliferation and migration of endothelial progenitor cells (2019, NA)
• Functional networks overrepresented in the list of DE mRNA in response to infection of bMDMs with Streptococcus agalactiae strain ST103 compared to uninfected controls (2019, Streptococcus agalactiae,Homo sapiens)
• construction of mutant E (2019, NA)
• Molecular mechanism by which RV hypertrophy (RVH) develops in response to pressure overload (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Sturnus vulgaris)
• The (a) glycolysis and (b) PKA-AMPK pathway genes and metabolites modulated by dietary BRBs during oral carcinogenesis (2019, NA)
• The action of dietary polysaccharides on the insulin signaling pathway (2019, NA)
• Diagrammatic summary of the dinoflagellate orthologues predicted in the nucleotide excision repair pathway (2019, NA)
• Druggable proteome across five classic cancer pathways (2019, NA)
• Proposed regulatory mechanism of estrogen in colitis-associated colorectal cancer at week 2 (A) and at weeks 10 and 16 (B) (2019, NA)
• NRs and cytokines signaling (2019, Escherichia coli,Enterococcus faecalis,Bacteroides fragilis,Citrobacter rodentium,Faecalibacterium prausnitzii,Lactobacillus crispatus,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,gut metagenome)
• Regulation of genes and myomiRs expression in the IGF/PI3K/Akt signaling pathway during myogenesis (2019, NA)
• The role of inflammasomes in lupus nephritis (2019, Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Clostridioides difficile,Bacillus anthracis,Streptococcus sp. group A,Hepatitis B virus,unidentified influenza virus,Gorilla papillomavirus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Wnt-EarlyEx tumors show expression of Wnt-associated pathway signatures (2019, NA)
• Signaling in AML FLT3-ITD (2019, NA)
• Schematic view of therapeutic opportunities targeting mutp53 and the homeostatic mechanisms it coordinates in cancer cells (2019, NA)
• Proposed model of the mechanism of GALNT6-mediated regulation of proliferation and metastasis thought Beta-catenin /MUC1-C signaling in breast cancer (2019, NA)
• The mechanism of miR-34 in EMT (2019, NA)
• Summary of Olea europaea extract and its active compounds’ mechanism of action on signaling pathway of EMT (2019, NA)
• The PI3K/AKT/mTOR/NFKB Pathway (2019, Homo sapiens,Mus musculus,unidentified)
• WNT pathway molecules and their involvement in chemoresistance in NB (2019, NA)
• DNA virus stimulation of the mitogen-activated protein kinase extracellular signal-regulated kinase (MAPK-ERK) cascade (2019, NA)
• Beneficial role of NSAIDs in cancer process (2019, NA)
• Canonical WNT/Beta-catenin pathway (2019, NA)
• miR526b and miR655 overexpressing cells showing significant down regulation of tumour suppressor gene phosphatase and tensin homolog (PTEN) mRNA expression (2019, NA)
• Molecular signaling of inflammatory pathways involved in structural remodeling (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus)
• Altered metabolism as the source of nadph biosynthesis (2019, NA)
• Protein network analysis of the overexpressed genes in the TLR non-responsive patient cells (2019, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Mus musculus)
• Filamin-A as a balance between Erk/Smad activities during cardiac valve development (2019, NA)
• Immunosuppressive role of tumour-associated macrophages (TAMs) (2019, NA)
• CSCs-activated signaling pathways: Schematic representation of the signaling pathway responsible for induction and maintenance of CSC state (2019, NA)
• Cilia-dependent and independent activation of Gli proteins (2019, NA)
• FGFR signaling pathway regulation (2019, NA)
• FGFR signaling pathway (2019, NA)
• Anti-neuroinflammatory modulation afforded by bakuchiol in activated microglia (2019, NA)
• Stearoyl-CoA desaturase 1 (SCD1) as a molecular target for anticancer therapy (2019, Homo sapiens)
• RANKL/RANK signaling pathway from stromal cells/OBs showing downward signaling molecules to the transcription factors in the nucleus that regulate OC differentiation (2019, Allium sativum,Prunus domestica,Citrus sudachi,Mus musculus,Rattus norvegicus,Homo sapiens,Paracheirodon innesi)
• Mechanism by which alantolactone (Ala) suppresses neuroinflammation (2019, Armoracia rusticana,Raphanus sativus,Ligusticum sinense,Inula helenium,Saussurea costus,Elephantopus scaber,Escherichia coli,Escherichia coli IS1,Escherichia coli O111B4,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Rac1 activation is regulated by GEFs and GAP (2019, Mus musculus,Rattus norvegicus,Homo sapiens,synthetic construct)
• Negative role of AMPK in angiogenesis (2019, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Bos taurus,Lycium barbarum)
• Regulation of sprouting angiogenesis (2019, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Bos taurus,Lycium barbarum)
• Illustration of proposed mechanisms of stem cell therapy in rescuing ischemia-reperfusion induced acute kidney injury (2019, NA)
• Molecular mechanism of soft-jet plasma-induced cancer cell apoptosis via the mitochondrial intrinsic pathway and extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activation (2019, NA)
• Unigenes involved in the Wnt signaling pathway: Red and green represent upregulated and downregulated genes, respectively (2019, Taenia pisiformis,Homo sapiens)
• Schematic diagram represents the mechanism of melatonin neuroprotection in mouse brains following traumatic brain injury (TBI) (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,Bovine leukemia virus)
• Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• PKZ-mediated signaling pathway (2019, Danio rerio,Oncorhynchus mykiss,teleost fish,Carassius auratus,Salmo salar,Dipnomorpha,Ctenopharyngodon idella,Paralichthys olivaceus,Carassius carassius,Gobiocypris rarus,Escherichia coli,Escherichia coli DH5alpha,Escherichia coli IS25,Human immunodeficiency virus 1,Human betaherpesvirus 5,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Activation of c-Rel signaling by the canonical NFKB pathway in B cells (2019, NA)
• Candidates of miRNA-based therapy against perinatal hypoxic-ischemic brain injury (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Lyssavirus rabies,Fusarium sp.)
• Possible mechanisms of cancers caused by Porphyromonas gingivalis (2019, NA)
• Points of complement inhibition (2019, NA)
• BmPGRP2 functional differentiation in host immune response to pathogens (2019, NA)
• Biochemical reactions of the phosphatidylinositol 3′-OH kinase (PI3K)-Akt and Nuclear Factor-kappaB (NFKB) pathway and its modularization (2019, Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Armoracia rusticana,Human papillomavirus)
• Expression patterns of the most relevant genes related to hormone biosynthesis/homeostasis, perception, and signal transduction plotted within the correspondent KEGG maps (the pathway code is also indicated at the top-right of eachmap) (2019, NA)
• Transfer RNA-derived fragment target genes in the Kyoto Encyclopedia of Genes and Genomes AMPK pathway map generated using DAVID software (2019, NA)
• Molecular signaling in cancer (2019, NA)
• NMP induced apoptosis in NSCLC cells by dual pathways (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Vasconcellea candicans)
• Simplified pathways showing the effect of F-6 cell proliferation and death (2019, Danio rerio,Armoracia rusticana,Zea mays,PX clade,Dipnomorpha,catfish,Euphorbia hirta,Esox lucius,Bos taurus,Oryctolagus cuniculus,Bison bonasus,Homo sapiens,Mus musculus)
• Role of the canonical Wnt/Beta-catenin pathway in cancer metabolism (2019, Homo sapiens,Mus musculus,Danio rerio,NA)
• Hypothetical G protein-coupled receptor (GPCR) heterodimeric T1R2/T1R3 taste receptors exist in a multimeric receptor complex with NMBR, IRB, and Neu-1 in naïve IR expressing cells (2019, NA)
• Cinobufagin-induced effects on hepatocellular carcinoma Huh-7 cells with mutant p53 (2019, NA)
• Neurotoxicity of Anesthetics: Mechanisms and Meaning from Mouse Intervention Studies (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Caenorhabditis elegans,unidentified)
• Metabolic pathway dysregulations in PD (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Equus caballus,Carassius auratus,Eleutherococcus senticosus)
• New therapeutics based on emerging concepts in pulmonary fibrosis (2019, NA)
• Schematic drawing of the proposed role of FGFR2c and its signaling in the regulation of autophagy and EMT interplay (2019, NA)
• MiR-146b-3p mediated regulatory mechanism in myoblast proliferation, differentiation, and apoptosis (2019, NA)
• Compounds that inhibit and activate autophagy (2019, NA)
• TNFAlpha-mediated necroptosis aggravates IRI in the fatty liver by regulating the inflammatory response (2019, Bos taurus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanisms responsible for ETR (endocrine therapy resistance) progression (2019, Homo sapiens)
• Role of LOXL3 in tumor (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Canis lupus familiaris,Diaporthe sclerotioides)
• Representation of the two serrated pathways (2019, gut metagenome,human gut metagenome,human metagenome,Homo sapiens,Mus musculus,Fusobacterium nucleatum)
• Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention (2019, NA)
• HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1B (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• The inhibitory effect of Gal-3BP on TAK1-dependent NFKB signaling pathway (2019, Human immunodeficiency virus,Dengue virus,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,NA)
• Protective potential of glucagon like peptide 2 (GLP-2) against the neurodegeneration (2019, Mus musculus,Rattus norvegicus,Agaricus bisporus,Homo sapiens)
• Indirect pathway striatal spiny module.The medium spiny neuron dendritic spine, the glutamatergic terminal and the dopaminergic terminal constitute the so-called striatal spiny module (SSM) (2019, Homo sapiens,Mus musculus,Eurhynchium striatum)
• Bioinformatics analysis of direct ERRA target genes in mouse liver (2019, NA)
• Neuroprotective effects of resveratrol in AD (2019, NA)
• Putative Cripto-1 targets the MAPK, FA and ErbB signalling pathways (2019, NA)
• Graphical summary of the anticancer mechanisms of formononetin (2019, Agaricus bisporus,Medicago sativa,Cicer arietinum,Astragalus membranaceus,Trifolium pratense,Glycyrrhiza glabra,Sophora flavescens,Astragalus mongholicus,Bipolaris zeicola,Trifolium subterraneum,Amorpha fruticosa,Ononis spinosa,Actaea racemosa,Cananga odorata,Pterocarpus indicus,Baptisia australis,Dalbergia stevensonii,Dalbergia ecastaphyllum,Phyllolobium chinense,Andira inermis,Bolusanthus speciosus,Glycyrrhiza pallidiflora,Euphorbia portlandica,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,unidentified)
• Mucins: the Old, the New and the Promising Factors in Hepatobiliary Carcinogenesis (2019, Homo sapiens)
• JAK/STAT pathway (2019, NA)
• RNA MODOMICS and heterogeneity of tumors (2019, NA)
• Proposed mechanism of apoptosis induction by 3-cloroplumbagin (ChPL) in breast cancer cells (2019, NA)
• Pterostilbene (PTS) prevented ROS formation and reversed palmitic acid (PA) mediated increase in hepatic glucose production by reducing expression of genes coding for gluconeogenic enzymes and their transcription factors (2019, Mus musculus,Rattus norvegicus,Armoracia rusticana,Pterocarpus marsupium,Homo sapiens)
• Cell signalling dysfunction in mTOR signalling pathway leading to syndromic and idiopathic autism (2019, NA)
• Various molecular inhibitors and stimulators in mTOR signalling pathway (2019, NA)
• HPV16 endocytosis and trafficking to multivesicular bodies (2019, NA)
• mTOR signaling network (2019, NA)
• The VEGF signaling pathway acting on endothelialization.Abbreviations: VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; Shc, src homology 2 domain containing; RAS, family of related proteins (2019, NA)
• Synthesis of triacylglycerol (TAG) (2019, NA)
• Regulation of the expression and cleavage of sterol regulatory element-binding protein-1c (SREBP-1c) and the transcriptional activation of the acyl-CoA:glycerol-sn-3-phosphate acyltransferase1 (GPAT1) gene (2019, NA)
• De novo synthesis of NAD(P) from tryptophan, nicotinamide and nicotinic acid (2019, Zea mays,Sorghum bicolor,Dimocarpus longan,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Apoptotic signaling during ER stress (2019, NA)
• Signal transduction pathway of EGFR (2019, NA)
• Proposed mechanisms model of Activin B on mouse vibrissae growth (2019, NA)
• Sirtuins and epigenetic regulation of immune cell functions (2019, NA)
• Probable molecular mechanistic pathway of ruthenium baicalein complex (2019, NA)
• The proposed mechanisms for the inhibitory effects of MS-275 on osteogenesis in VICs (2019, NA)
• After the skin was injured to form a wound, the alarm signal has bound and activated the NLRP3 inflammasome by damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) (2019, NA)
• Proposed mechanisms of nitrergic neurotransmission in the SIP syncytium (2019, NA)
• Biochemical process networks of the differentially expressed proteins generated by MetaCore™ software using a transcription regulation algorithm (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,prion,Chlamydomonas reinhardtii)
• Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis (2019, Homo sapiens,Mus musculus)
• Intracellular signaling mechanism after sequential treatment with gliotoxin followed by paclitaxel in human ovarian cancer cells (2019, Aspergillus fumigatus,Aspergillus sp.,Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Schematic diagram showing the activation of Ca2+ signal transduction pathway and other miscellaneous pathways in response to the electrical and mechanical stimulations (2019, NA)
• Summary diagram of signaling pathway of this study (2019, NA)
• RNF8 involves in DSB signaling pathway (2019, NA)
• Dimensionality and the cell malignancy potential on lipid species amounts in the MCF10A breast cancer in vitro model (2019, Homo sapiens,PX clade)
• Various regulatory mechanisms of MALAT1 in different diabetes-related complications (2019, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus,clinical samples)
• Negative regulation between FoxO3a and EPS8 in EGF/PI3K/Akt pathway (2019, NA)
• TLR signaling pathways (2019, NA)
• NK cell transduction pathways involved in primary immunodeficiencies (2019, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Human gammaherpesvirus 4)
• GLI1 activation by non-classical pathway integrin AvB3/ERK1/2 maintains stem cell-like phenotype of multicellular aggregates in gastric cancer peritoneal metastasis (2019, NA)
• Complement dysregulation in complement-mediated HUS Complement activation initiated by any of the three pathways (classical, alternative, or lectin pathway) leads to C3 activation and C3 convertase formation on C3-opsonized surfaces (2019, Escherichia coli,Campylobacter jejuni,Escherichia coli O157H7,Escherichia coli O104H4,Homo sapiens,Mus musculus,Osphranter robustus)
• DMAMCL-mediated cell death in human glioma cells.Abbreviations: DMAMCL, dimethylaminomicheliolide; ROS, reactive oxygen species (2019, NA)
• Synthesis pathway of cardiolipin from lysophosphatidylcholine and lysophosphatidic acid (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Triportheus paranensis)
• Notch and APP signalling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,prion)
• Pivotal functions of the molecules in heme metabolic pathway in inflammation (2019, NA)
• Heme metabolic pathway (2019, NA)
• Changes in expression of genes involved in ethanol oxidation and TCA cycle in K (2019, NA)
• Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis (2019, NA)
• Overview of direct and indirect pro-allergenic immune responses to anti-ulcer drugs (AUD) (2019, Clostridioides difficile,Clostridioides difficile CD3,Homo sapiens,Mus musculus,gut metagenome)
• Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients’ skin fibroblasts (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• Graph representation of the Signaling by NOTCH2 pathway as extracted from the Reactome database (2019, NA)
• The mechanism by which ASIC1a attenuates the activation of autophagy via elevated intracellular calcium levels and the CaMKKB/AMPK/mTOR signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Amitermes group)
• ceRNA regulatory network associated with the MAPK signaling pathway (2019, NA)
• Longitudinal multi-omics of host–microbe dynamics in prediabetes (2019, gut metagenome,metagenome,human gut metagenome,human metagenome,Respiratory syncytial virus,Enterovirus,Human rhinovirus sp.,Homo sapiens,Mus musculus,Clarkia concinna,unclassified Butyricicoccus)
• Signalling pathways related to PRL-3/EGFR/c-myc genes in cancer cells (2019, NA)
• Rickettsia conorii and R (2019, Rickettsia conorii,Homo sapiens)
• Dynamic mechanism of ADP-ribosylation reversal (2019, Drosophila melanogaster,Dryas iulia,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Herpetosiphon aurantiacus)
• Predicted mechanisms of ELF1 regulation of doxorubicin-induced apoptosis (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Bikinia letestui)
• Proposed model of the Lgr5-mediated stimulation of cancer growth through activation of the Wnt/Beta-catenin signaling pathway (2019, NA)
• The canonical Wnt signaling pathway (2019, NA)
• Ex vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery (2019, Homo sapiens,Mus musculus,murine stem cell retroviral vector)
• Network visualization of the calcium signaling pathway with expression and GWAS information (2019, NA)
• KEGG AD pathway (2019, NA)
• Diagrammatic representation of human hedgehog signaling pathway (2019, Mus musculus,Danio rerio,Xenopus laevis,Chinchilla chinchilla,Homo sapiens,Drosophila melanogaster,Helicobacter pylori,Veratrum californicum)
• Proposed molecular mechanisms of PAX3 in glioma pathogenesis and progression (2019, Homo sapiens,Mus musculus,Xenopus laevis)
• Intrinsic pathway refers to mainly mitochondrial-mediated apoptotic pathway (2019, NA)
• Smad3 linker phosphorylation negatively regulates transforming growth factor‐B (TGF‐B)/Smad3 signaling (2019, Homo sapiens,Mus musculus)
• Hypothetical scenarios for the role of NGF after systemic oxidative stress (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Solanum lycopersicum,Equus caballus,Matthiola incana,Homo sapiens,Xenopus laevis)
• Proposed model to explain how COX-2 might be essential in the stimulatory pathway for ROS production and increased expression of profibrotic genes mediated by PRR activation (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Macaca mulatta,Equus asinus)
• Different types of GSLs (2019, NA)
• Cerebellum (CB)-specific biological processes in Alzheimer’s disease (AD) brain (2019, NA)
• Signaling cascade in RANKL-RANK induced osteoclastogenesis: A model of IRF8-mediated regulation of osteoclast differentiation (2019, NA)
• Neuroprotective effects of DBS at the synapse (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGFB signaling as well as the role of TGFB signaling pathway in cancer onset and progression (2019, NA)
• Roles and regulation of PAH1-encoded PA phosphatase in lipid synthesis (2019, NA)
• Cell cycle timing and regulation of replicative histone genes (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Gallus gallus,Xenopus laevis,Schizosaccharomyces pombe,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,H4N1 subtype)
• The signaling pathway for membrane glucocorticoid receptor-induced endocannabinoid synthesis (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Xenopus laevis)
• Activated TLR4 signal inhibited by neurosteroids (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Zea mays,Macaca fascicularis,Human alphaherpesvirus 2,Apogon leslie)
• Signaling pathway explains how PERK activation affects CREB signaling and memory impairment (2019, NA)
• Gene network on chemokine signaling pathway by KEGG analysis of module-related DEGs (2019, NA)
• AMPK Signaling Pathway (2019, NA)
• Working model (2019, Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Matthiola incana,Agaricus bisporus,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• PPAR signaling pathway and DEGs.Abbreviation: DEGs, differentially expressed genes (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Schematic of TriPOINT (2019, NA)
• Three branches of the unfolded protein response (UPR) (2019, NA)
• Mechanisms involved in the regulation of glycometabolism in T2DM by RC (2019, NA)
• IA through the JNK Signaling Pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Viola sororia,Homo sapiens,Escherichia coli)
• CCN2–MAPK–Id-1 loop feedback amplification is involved in maintaining stemness in oxaliplatin-resistant hepatocellular carcinoma (2019, NA)
• Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Cryptosporidium parvum)
• Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Cryptosporidium parvum)
• Pathways associated with long-term potentiation in the pre-and post-synaptic membrane (2019, NA)
• Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease (2019, Mus musculus,Rattus norvegicus,Corynocarpus laevigatus,Annona reticulata,Homo sapiens,Danio rerio,Mouse mammary tumor virus)
• Metabolic engineering strategies for enhancing citric acid production (2019, NA)
• SiNPs-induced apoptotic and necrotic cell death pathways independently in HUVECs (2019, NA)
• Mechanisms involved in Notch-mediated therapeutic resistance (2019, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Human betaherpesvirus 5)
• Other Notch-related tumorigenic aspects in the pathogenesis of Glioblastoma (2019, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Human betaherpesvirus 5)
• The Notch signaling pathway (2019, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Human betaherpesvirus 5)
• Reprogramming of lipid metabolism under hypoxia (2019, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Associative gene network describing interactions between three central genes/proteins of the extrinsic apoptotic signaling pathway biological process (2019, NA)
• Multiple nonunidirectional levels through which autophagy-related processes in senescence affect regulation of SASP genes, often via NFkB activation (2019, Measles morbillivirus,Satellites,Homo sapiens,Mus musculus,transposons)
• Genetic risk factors and synapse dysfunction in AD pathogenesis (2019, NA)
• Activation of antiviral pathways in Atlantic cod (2019, Gallus gallus,Danio rerio,Oncorhynchus mykiss,teleost fish,Cyprinus carpio,Carassius auratus,Salmo salar,Dipnomorpha,Xenopus tropicalis,Anas platyrhynchos,Oreochromis niloticus,Paralichthys olivaceus,Epinephelus coioides,Gadus morhua,Takifugu rubripes,Sparus aurata,Larimichthys crocea,Scophthalmus maximus,Taeniopygia guttata,Carassius carassius,Siniperca chuatsi,Callorhinchus milii,Cyprinus carpio color,Alligator mississippiensis,Oplegnathus fasciatus,Abramis brama,Esox lucius,Protacanthopterygii,Crocodylus porosus,Nothobranchius guentheri,Sciaenops ocellatus,Niphon spinosus,Hyporthodus octofasciatus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Vesicular stomatitis virus,Dengue virus type 2,Suid alphaherpesvirus 1,Grass carp reovirus,Isavirus salaris,Viral hemorrhagic septicemia virus,Infectious spleen and kidney necrosis virus,Ostreid herpesvirus 1,Chum salmon reovirus CS,Crassostrea gigas,Branchiostoma lanceolatum,Tetrahymena thermophila,Branchiostoma japonicum,Homo sapiens,Pan troglodytes,Mus musculus,Bos taurus,Aeromonas salmonicida,NA,NA)
• Statins on several pathways involved in bone metabolism (2019, NA)
• Functional enrichment analysis of the 2,397 intersected differential genes (2019, Homo sapiens)
• The mechanism of PP26 induction of G2/M-phase arrest in HepG2 cells (2019, NA)
• Mechanism of action of ALK inhibitors (2019, NA)
• Pyruvate and glutamate are 2 major metabolic hubs in GSCs (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities (2019, NA)
• Signaling pathways involved on induction of endoplasmic reticulum (ER) stress (2019, NA)
• Systems biology reveals how altered TGFB signalling with age reduces protection against pro-inflammatory stimuli (2019, NA)
• Interferon-gamma (IFNG) pathway and its modeled representation to demonstrate the step-by-step calculations for protein-protein interactions at each node in this pathway and as an annexure section of other pathways (2019, NA)
• A modeled signaling pathway using a G Protein Coupled Receptor activation as an example (2019, NA)
• Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer (2019, NA)
• Synergistic effect of three combined strategies by targeting complement/C3aR /C5aR1/IL-10 pathway and other treatment modalities (2019, Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Panthera tigris)
• Central metabolism in the S (2019, Aedes aegypti,Trypanosoma brucei,Rhodnius prolixus,Glossina morsitans,Anopheles stephensi,Lutzomyia longipalpis,Sitophilus oryzae,Glossina morsitans morsitans,Homalodisca vitripennis,Henestaris halophilus,Phlebotomus chinensis,Rhodnius ecuadoriensis,Helicobacter pylori,Serratia marcescens,Escherichia coli BW25113,Halobacillus halophilus,Wolbachia endosymbiont of Drosophila melanogaster,Wigglesworthia glossinidia,Blattabacterium cuenoti,Candidatus Karelsulcia muelleri,Rhodococcus rhodnii,Candidatus Sodalis pierantonius,Homo sapiens,Matthiola incana)
• ProQ-dependent changes in Salmonella-infected HeLa cells (2019, Salmonella enterica,Homo sapiens)
• Complex interplay between CCT and actin and tubulin (2019, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Caenorhabditis elegans,Human immunodeficiency virus)
• Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice (2019, NA)
• Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice (2019, NA)
• Other stimuli leading to necroptosis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Murid betaherpesvirus 1)
• TNFR1-mediated signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Murid betaherpesvirus 1)
• Pathways to DHT synthesis (modified from Ref (2019, NA)
• Sugar sensing and signaling in S (2019, NA)
• Circular RNA profile in liver tissue of EpCAM knockout mice (2019, NA)
• Antibactericidal mechanisms of C5a-TLR2 cross-talk induced by P (2019, NA)
• Contrast inflammatory signals in human gingival fibroblasts triggered by the different acylation structures of P (2019, NA)
• Sugar sensing and signaling in C (2019, NA)
• Cilia-dependent regulation of PDGFRA signaling pathway (2019, NA)
• Summary of the neuroprotective action of resveratrol (2019, NA)
• Hydrogen peroxide mediates pro-inflammatory cell-to-cell signaling: a new therapeutic target for inflammation? (2019, Agaricus bisporus,Cinnamomum verum,Cinnamomum aromaticum,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• The role of p38 mitogen-activated protein kinase (MAPK) in host cell death (2019, Mycobacterium tuberculosis,Salmonella enterica,Bacillus anthracis,Mycobacterium tuberculosis str. Erdman ATCC 35801,Homo sapiens,Rattus norvegicus,Human immunodeficiency virus 1)
• Significant dysregulation of P53 pathway in urothelial cells exposed to either S (2019, NA)
• Targets molecules of bta-mir-182 involved in the apoptosis signaling pathway (2019, NA)
• Significant dysregulation of genes involved in Colorectal Cancer Signaling Pathway in urothelial cells (2019, NA)
• Six main metabolic pathways relevant for immune cell function (2019, NA)
• Ferroptosis induction (2019, Homo sapiens,Mus musculus)
• Schematic figure illustrating the signalling pathway activation with mechanical ventilation and endotoxaemia (2019, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Vasconcellea candicans,Homo sapiens,Gallus gallus,Coxsackievirus B3)
• Mechanism of the loss of cell polarity in CBDL rat lung (2019, NA)
• SakA and MpkC SAPK pathway in Aspergillus fumigatus (2019, Aspergillus fumigatus,Homo sapiens)
• FGFR1 pathway promotes NFKB signaling (2019, NA)
• Strategies to inhibit insulin induced PCa invasion and plasticity (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Cricetulus griseus,Homo sapiens,Diaporthe sclerotioides,clinical samples)
• Stimulation of TLRs activates multiple signaling pathways (2019, Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Porphyromonas gingivalis,Limosilactobacillus reuteri,Prevotella melaninogenica,Metamycoplasma salivarium,Capnocytophaga ochracea,Mus musculus,Rattus norvegicus,Candida dubliniensis,Aspergillus fumigatus,Homo sapiens,Drosophila melanogaster,gut metagenome)
• Possible EPO signaling pathway (2019, NA)
• Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A (2019, NA)
• RIG-I/MDA5 signaling pathway RIG-I and MDA5 are first activated by recognition of PAMP dsRNA, which causes them to interact with MAVS (2019, NA)
• n-Butanol pathway combinations (2019, NA)
• Intracellular vesicular trafficking-cellular organelle rough endoplasmic reticulum (RER) Coat protein I and Coat protein II form vesicles that mediate cargo transport between Golgi to ER and ER to Golgi, respectively (2019, NA)
• Representation of S100B effects on Caco-2 cells (2019, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Glycine max,Homo sapiens,Mus musculus)
• Signaling pathways selected for the evaluation of the biological effects of essential oils (2019, Armoracia rusticana,Curcuma longa,Cinnamomum verum,Ocimum basilicum,Angelica sinensis,Origanum vulgare,Melissa officinalis,Citrus nobilis,Copaifera langsdorffii,Copaifera multijuga,Homo sapiens,Mus musculus,Bos taurus)
• Therapeutic benefits of Selective D2R-Beta-arrestin2 ligands in prefrontal cortex and basal ganglia in schizophrenia (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed antipsychotic actions to confer bias of GPCR signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• G protein-coupled receptor (GPCR) signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mutual interactions of expression of the genes examined with qPCR and shown in , and (2019, NA)
• Mechanism of Activation for the Non-Canonical and Alternative NLRP3 Inflammasome Pathways (2019, Pseudomonas aeruginosa,Bacillus cereus,Streptococcus sp. group B,Francisella tularensis subsp. novicida,Leptospira kmetyi,Diaporthe sclerotioides,Candida albicans,Influenza A virus,Human alphaherpesvirus 1,Homo sapiens,Mus musculus,Triportheus paranensis)
• Possible mode of cell death pathway in Caco-2 cells (2019, NA)
• Mechanism of Action of Phenformin (2019, Homo sapiens,Mus musculus,Galega officinalis)
• Activity pathways for apoptosis induction resulting from cereal phenolic compound exposure (↓ downregulation, ↑ upregulation, Caspase (Cas), pro-apoptotic protein (Pro-AP), anti-apoptotic protein (anti-AP)) (2019, Oryza sativa,Hordeum vulgare,Matthiola incana,Sorghum bicolor,Avena sativa,Homo sapiens,Rattus norvegicus,Bos taurus)
• Phagocytic pathway in glial cells (2019, NA)
• Different sources of EVs in the cancer-to-stroma communication network (2019, NA)
• Summary of epigenetic and gene expression differences in the insulin and PI signaling pathways (2019, NA)
• “photosynthesis” pathway enriched by KEGG analysis of DE mRNA corresponding genes in the cultivar “Huoche” under heat stress (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Glycine max,Solanum lycopersicum,Triticum aestivum,Cucumis sativus,Sorghum bicolor,Raphanus sativus,Capsicum annuum,Brassica rapa,Brassica rapa subsp. pekinensis,Jatropha curcas,Populus tomentosa,Gigaspora gigantea,Homo sapiens,Mus musculus)
• Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment (2019, NA)
• Proposed molecular mechanisms underlying the inhibitory effect of NAB on the LPS-activated RAW264.7 macrophages (2019, NA)
• Pathways affected by the combined selected kinase inhibitors in BRAF mutant melanoma cells (2019, NA)
• Activation of the Akt signaling pathway by ST6GALNAC1 enables tumor cells to acquire stem cell stemness (2019, NA)
• AnvM-mediated regulation and its interaction with host cell (2019, NA)
• Reaction-based specification of the model according to the notation previously introduced (2019, Arabidopsis thaliana,Neurospora crassa,Homo sapiens,Mus musculus)
• Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference (2019, NA)
• Proposed schematic depicting the signalling pathway via which TGFB1 promotes the osteogenesis and migration of osteoblasts (2019, NA)
• Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma (2019, Homo sapiens)
• Milk exosomes and allergy prevention (2019, NA)
• New Blue Donor–Acceptor Pechmann Dyes: Synthesis, Spectroscopic, Electrochemical, and Computational Studies (2019, Homo sapiens,Leptospira kmetyi)
• Osteopontin (OPN)-induced B1-integrin activation and HIV-1 envelope signaling converge on mTORC1/2 pathways in a mechanism that promotes neurite outgrowth (2019, NA)
• Tumor microenvironment influences the metabolic status of cancer cells with consequences for their metastatic potential (2019, NA)
• Beneficial role of curcumin in cancer (2019, NA)
• Curcumin actions on the WNT pathway in cancer therapy (2019, NA)
• Schematic presentation depicting the energy metabolic pathways through which AMPK controls the activation of MDSCs (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Human gammaherpesvirus 4)
• Schematic presentation depicting the signaling connections through which AMPK signaling controls the major activation pathways of MDSCs (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Human gammaherpesvirus 4)
• Pharmacology of rapid-acting antidepressants in corticomesolimbic brain circuits (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Panthera tigris)
• Illustration of the anti-fibrotic effects and their relationship between TAF and NS5ATP9 in BLM-induced pulmonary fibrosis (2019, NA)
• Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke (2019, NA)
• Glutamatergic synapse (path:hsa04724) pathway mapping of the protein targets of DPCs: The location of protein targets of DPCs in the KEGG pathway hsa04724 is represented in yellow and red coloured boxes, red ones are specific to mGluRs (2019, NA)
• Simplified overview of one-carbon metabolism pathway (2019, NA)
• Schematic model of SNHG6 in CRC cells (2019, NA)
• Glycolysis pathway in the heart (2019, NA)
• Identification, expression, alternative splicing and functional analysis of pepper WRKY gene family in response to biotic and abiotic stresses (2019, NA)
• Mechanisms by which carbon-based nanoparticles induce cytotoxicity of macrophages (2019, NA)
• Partial diagram of the “Signaling by SCF-KIT” pathway showing the feedback loop that generates the “p-STAT dimers” complex annotated in Reactome (2019, Homo sapiens,NA)
• MyD88 played a critical role in alveolar macrophage-mediated inflammatory response to CNTs (2019, NA)
• PRR signalling pathways (2019, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Nakaseomyces glabratus,Candida tropicalis,Histoplasma capsulatum,Candida parapsilosis,Pneumocystis carinii,Candida auris,Trichophyton rubrum,Pneumocystis jirovecii,Blastomyces dermatitidis,Sporothrix schenckii,Fonsecaea pedrosoi,Coccidioides posadasii,Malassezia furfur,Coccidioides immitis,Fonsecaea monophora,Mycobacterium tuberculosis,Rubinisphaera brasiliensis,Homo sapiens,Mus musculus,gut metagenome)
• ETC and ATP synthase are required for normal eye development (2019, Drosophila melanogaster,Homo sapiens)
• Schematic diagrams of the CWI pathway (A) and the HOG pathway (B) in S (2019, NA)
• Schematic diagram summarizing the anti-NSCLC action of butein via activation of ER stress and ROS generation (2019, Diaporthe sclerotioides,herbal medicine,Toxicodendron vernicifluum,Piper methysticum,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Relation graph of KEGG pathways in which differentially expressed genes were significantly enriched (2019, NA)
• GPCR signaling (2019, Homo sapiens)
• Recapitulative diagram of IL-15 pathway involved in TGFB signaling (2019, NA)
• Ovarian cancer stem cells and macrophages reciprocally interact through the Wnt pathway to promote a pro-tumoral microenvironment (2019, Homo sapiens,Mus musculus,Bos taurus,Escherichia coli)
• LAIR1 signalling pathway in malaria.The LAIR1 pathway is activated by attachment of collagen and collagenous ligands (C1q) to LAIR1 extracellular surface (2019, Plasmodium falciparum,Plasmodium falciparum HB3,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,clinical samples)
• The complement system, showing approximately 50 directly involved soluble and membrane-bound complement proteins (2019, Staphylococcus aureus,Streptococcus pneumoniae,Streptococcus pyogenes,Neisseria meningitidis,Neisseria meningitidis serogroup B,Influenza A virus,Respiratory syncytial virus,Homo sapiens,Mus musculus)
• Novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NFKB inactivation in colorectal cancer cells (2019, Armoracia rusticana,Diaporthe sclerotioides,Curcuma longa,Fraxinus berlandieriana,Homo sapiens,Bos taurus)
• Exogenous H2S restores PC-induced cardioprotection by up-regulating the HB-EGF/EGFR pathway, which activates the ERK1/2-c-myc (and fos and c-jun) and PI3K-Akt-GSK-3B pathways in the aged cardiomyocytes (2019, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Helicobacter pylori)
• Main aspects of folate receptor signaling and C1 metabolism discussed during the meeting (2019, Saccharomyces cerevisiae,Anacardium occidentale,Podocarpus latifolius,Mus musculus,Rattus norvegicus,Homo sapiens)
• In vivo safety evaluations of MOv18 IgE (2019, NA)
• Architecture of the Fanconi anemia (FA) core complex, with FAAPs (Fanconi anemia–associated proteins) indicated by numbers (2019, Homo sapiens,Mus musculus,Gallus gallus)
• Roles of FA proteins in replication stress (2019, Homo sapiens,Mus musculus,Gallus gallus)
• Illustration of FGF1 signaling in Leydig cell development (2019, NA)
• CXCL13 in prostate cancer (2019, NA)
• Proposed model of MEK as a key regulatory pathway of the IFN response against RV and RSV in airway epithelial cells (2019, NA)
• An example of autocrine and paracrine interactions between NPY neuron (blue) and POMC neuron (green) in the ARC and their downstream effector neuron (i.e., neuron in PVN; beige) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Tissue-specific gene regulatory network of the top KDs in psoriasis (2019, NA)
• Signaling pathway involved in papain-hydrolyzed glycomacropeptide modulation on HepG2 cell response to hydrogen peroxide or to high-glucose conditions (2019, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Lacticaseibacillus casei,Lactobacillus acidophilus,Streptococcus mutans,Bifidobacterium longum,Bifidobacterium bifidum,Bifidobacterium longum subsp. infantis,Bifidobacterium animalis subsp. lactis,Salmonella enterica subsp. enterica serovar Enteritidis,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Streptococcus sanguinis,Lactiplantibacillus pentosus,Bacillus infantis,Morganella morganii,Empedobacter brevis,Streptococcus sobrinus,Actinomyces viscosus,Desulfovibrio sp.,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Macaca mulatta)
• Overexpression of IL-6 and its potential negative consequences on the viral immune response (2019, NA)
• Pathogenic role of connective tissue growth factor in osteoarthritis (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• The central role of C1 inhibitor in various plasma systems., Upon contact with negatively charged surfaces factor XII (FXII) is (auto‐) activated to activated factor XIIa (FXIIa) (2019, NA)
• Cellular glycolysis and oxidative phosphorylation (2019, Diaporthe sclerotioides,Vasconcellea candicans,Homo sapiens,Mus musculus,Bos taurus,Triportheus paranensis)
• READ pathways (p53 signaling pathway, intestinal immune network for IgA production, and colorectal cancer pathway) enriched in DEmRNAs during READ (2019, NA)
• Conceivable migration pathway related to PNETs based on literatures (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Summary scheme represents the possible pathways of drug sensitive and drug resistance to cordycepin in MA‐10 mouse Leydig tumor cells (2019, NA)
• NADPH oxidase 4 mediates TGFB1/Smad signaling pathway induced acute kidney injury in hypoxia (2019, NA)
• The wild-type CARD9 protein consists of an N-terminal caspase activation and recruitment domain (CARD) followed by a coiled-coil domain and a C-terminal tail (2019, Candida albicans,Aspergillus fumigatus,Candida tropicalis,Candida albicans 23R,Saccharomycopsis fibuligera,Listeria monocytogenes,Citrobacter rodentium,Limosilactobacillus reuteri,Homo sapiens,Mus musculus,gut metagenome)
• Nobiletin inhibiting proliferation and inducing apoptosis (2019, NA)
• Beta-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma (2019, Saccharomyces cerevisiae,Armoracia rusticana,Thuja plicata,Thujopsis dolabrata,Thujopsis dolabrata var. hondae,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Functional prediction of key lncRNA-mRNAs network (2019, Homo sapiens,Mus musculus,Human papillomavirus)
• Regulatory loop among Kaiso, Wnt11/5a and Suz12 (2019, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Helicobacter pylori,NA)
• In monocytes/macrophages and adipocytes, SIRT1 deacetylates NFKB(p65), resulting in reduced expression of inflammatory mediators such as TNFA and MCP-1 (2019, NA)
• Schematic illustration showing anti-inflammatory responses in RAW 264.7 cells after treatment with AS-6 (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Ascochyta viciae,Homo sapiens,Escherichia coli)
• Fludarabine Improves NDV-Mediated Oncolytic Viro-immunotherapyOn the one hand, the viral RNA activates the cytoplasmic RIG-I signaling pathway in the host cells to produce type I IFNs or other antiviral molecules (2019, Hepatitis B virus,Human alphaherpesvirus 1,Measles morbillivirus,Human alphaherpesvirus 3,Reovirus sp.,Ebola virus sp.,Replication competent viruses,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Armoracia rusticana,NA,NA,NA,NA,NA)
• RIG-I, MDA5, LGP2, PKR, and TLRs3/7/8 are activated during viral infection in the presence of non-self dsRNA (2019, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Influenza A virus,Human alphaherpesvirus 1,Human papillomavirus,Dengue virus,Respiratory syncytial virus,Human papillomavirus type 16,Orthomyxoviridae,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Zika virus,Human T-cell leukemia virus type I,West Nile virus,DNA viruses,Ebola virus,Enterovirus C,Japanese encephalitis virus,Human alphaherpesvirus 2,Coxsackievirus B3,Encephalomyocarditis virus,Human alphaherpesvirus 3,Reovirus sp.,Coxsackievirus,Simian immunodeficiency virus,Yellow fever virus,Human immunodeficiency virus 2,Murine leukemia virus,Dengue virus group,Zaire ebolavirus,Ectromelia virus,Kunjin virus,Invertebrate iridescent virus 6,Yellow fever virus group,Coxsackievirus B1,Cedar virus,Alkhumra hemorrhagic fever virus,Cardiovirus A,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Campylobacter jejuni,Chlamydia trachomatis,Francisella tularensis,Legionella pneumophila,Francisella tularensis subsp. novicida,Chlamydia muridarum,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Gallus gallus,Svunavirus sv1,NA,NA,NA,NA,NA,NA)
• Signaling pathway involved in intact or papain-hydrolyzed glycomacropeptide modulation on RAW 264.7 macrophage response to lipopolysaccharide or hydrogen peroxide (2019, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Lacticaseibacillus casei,Lactobacillus acidophilus,Streptococcus mutans,Bifidobacterium longum,Bifidobacterium bifidum,Bifidobacterium longum subsp. infantis,Bifidobacterium animalis subsp. lactis,Salmonella enterica subsp. enterica serovar Enteritidis,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Streptococcus sanguinis,Lactiplantibacillus pentosus,Bacillus infantis,Morganella morganii,Empedobacter brevis,Streptococcus sobrinus,Actinomyces viscosus,Desulfovibrio sp.,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Macaca mulatta)
• Biosynthetic pathways of branched short-chain alcohols and esters and their regulation in S (2019, NA)
• L-proline-mediated differentiation of mESCs to EPL cells (2019, Homo sapiens)
• Cell signalling events that mediate the switch between self-renewal and differentiation in mouse embryonic stem cells (2019, Homo sapiens)
• Activation of the MAPK signaling pathway by miR-30e (2019, NA)
• Breast cancer cell-based pathobiochemical pathways showing LPHN-induced activation of PKCA, which triggers the translocation of Tim-3 and galectin-9 onto the cell surface which is required for immune escape (2019, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Homo sapiens,Mus musculus,Hepatitis B virus)
• Interaction network of proteins overexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 116) (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Bos taurus,Sus scrofa,Equus caballus,Homo sapiens,unidentified)
• Interaction network of proteins underexpressed in in vitro matured cumulus complexes (interaction confidence: high (> 0.7), database matches n = 82) (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Bos taurus,Sus scrofa,Equus caballus,Homo sapiens,unidentified)
• Wnt/Beta-catenin signal transduction pathway (2019, Homo sapiens,Hepatitis B virus,Macaca mulatta,Human papillomavirus type 16,H1N1 subtype,Pan troglodytes,Macaca fascicularis,Betapolyomavirus macacae,Hylobates sp.,Hepatitis delta virus,Mus musculus,Rattus norvegicus,Marmota monax,Sus scrofa,Tupaia glis,Lareunionomyces loeiensis,clinical samples,NA)
• Synthetic metabolic pathway for isobutanol production in E (2019, NA)
• Signaling pathway involved in THP-1 human monocyte activation by glycomacropeptide (2019, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Lacticaseibacillus casei,Lactobacillus acidophilus,Streptococcus mutans,Bifidobacterium longum,Bifidobacterium bifidum,Bifidobacterium longum subsp. infantis,Bifidobacterium animalis subsp. lactis,Salmonella enterica subsp. enterica serovar Enteritidis,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Streptococcus sanguinis,Lactiplantibacillus pentosus,Bacillus infantis,Morganella morganii,Empedobacter brevis,Streptococcus sobrinus,Actinomyces viscosus,Desulfovibrio sp.,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Macaca mulatta)
• Cellular and molecular responses to extracellular and intracellular DNA (2019, NA)
• Differential genes: the PI3K-Akt signaling pathway (2019, NA)
• Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis (2019, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Cricetus cricetus,Phodopus sungorus,Vicugna pacos,Bison bonasus,Gallus gallus,Sparus aurata,Homo sapiens,Zika virus)
• Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis (2019, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Cricetus cricetus,Phodopus sungorus,Vicugna pacos,Bison bonasus,Gallus gallus,Sparus aurata,Homo sapiens,Zika virus)
• Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis (2019, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Cricetus cricetus,Phodopus sungorus,Vicugna pacos,Bison bonasus,Gallus gallus,Sparus aurata,Homo sapiens,Zika virus)
• Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis (2019, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Cricetus cricetus,Phodopus sungorus,Vicugna pacos,Bison bonasus,Gallus gallus,Sparus aurata,Homo sapiens,Zika virus)
• Innate immune response activation in BRCA2-deficient cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• A) Experimental design depicting the sampling time points represented as days post hatching (dph) during the different gonad developmental stages covered by the study (2019, Dicentrarchus labrax,Gallus gallus,Danio rerio,Oncorhynchus mykiss,teleost fish,Oryzias latipes,Xenopus tropicalis,Salmo trutta,Oreochromis niloticus,catfish,Takifugu rubripes,Tetrapoda,Sparus aurata,Tetraodon nigroviridis,Taeniopygia guttata,Gasterosteus aculeatus,Pelodiscus sinensis,Lepisosteus oculatus,Odontesthes bonariensis,Acanthopagrus schlegelii,Acanthomorphata,Silurus meridionalis,Homo sapiens,Mus musculus,NA)
• Schematic diagram showing the proposed signalling pathways for inflammatory and autoimmunity‐associated gene expression via Ca2+ and Ca2+‐dependent/‐binding proteins (2019, NA)
• KXS ameliorated behavioral and pathological deterioration via the improvement of neurotransmitters and PI3K/Akt signaling pathways on the AD model (2019, NA)
• Proposed model for the impact of targeted therapeutics, vemurafenib (PLX) and trametinib (TRA) on differentiated/pigmented phenotype of melanoma cells (2019, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Schematic model of ROS-activated signaling involved in the rapid modulation of NGB levels, its localization, and function on the redox balance outside mitochondria (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• E2 intracellular activated pathway impacting on NGB expression levels/intracellular localization and the related antiapoptotic role of both mitochondrial NGB and AKT which appears to be double linked with NGB function (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Network of Wnt signaling regulates tumor metabolism reprogramming (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Gallus gallus,Human gammaherpesvirus 4,Fusobacterium nucleatum)
• metabolic pathways in cancer cells (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Gallus gallus,Human gammaherpesvirus 4,Fusobacterium nucleatum)
• Protein associations and potential functions of SHARPIN in human megakaryocytes and platelets (2019, Homo sapiens)
• Isolation of svh-6 RNAi (2019, Homo sapiens,Caenorhabditis elegans)
• Enriched KEGG pathways generated by ClueGO and Cluepedia (2019, Homo sapiens)
• Activation modes of the NLRP3 inflammasome and the regulatory mechanism of CVDs (2019, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,prion)
• Targeting pathways and molecules in the treatment of NMSC (2019, NA)
• hBM-MSCs-Ex treatment alleviates liver fibrosis in both HSCs and liver fibrosis tissues through inhibition of Wnt/Beta-catenin signaling (PPARG, Wnt3a, Wnt10b, Beta-catenin) and the downregulation of downstream gene expression (WISP1, Cyclin D1) (2019, NA)
• Rb pathway loss and assays for their detection (2019, Homo sapiens)
• Chronic hyperglycemia impairs neuron function (2019, NA)
• Ezrin-induced pancreatic cancer cell proliferation, invasion, and EMT progression (2019, Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Armoracia rusticana)
• Cyclin D1–CDK4/6–Rb pathway in breast cancer (2019, NA)
• Potential signaling pathways (2019, NA)
• Genes were clustered in the PPI network according to string database (genes from top 10 predicted pathways in BQG-treated group versus BLM group) (2019, NA)
• EP receptors and their downstream signaling: PGE2 binds to its cognate receptors, the E-series of prostaglandin receptors (EP1–EP4) on the plasma membrane and nuclear membrane (2019, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Cavia porcellus,Human gammaherpesvirus 4,Cricetulus griseus,Cricetus cricetus,Respiratory syncytial virus,Human gammaherpesvirus 8,Human betaherpesvirus 6A,Homo sapiens,Xenopus laevis,NA,NA)
• Modulating PI3K-Akt signaling pathway of SCD (2019, NA)
• LPS-mediated platelet activation and TLR4 expression in canine platelets (2019, NA)
• Iatrogenic interference with the initiation of antifungal immunity (2019, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Nakaseomyces glabratus,Carex albicans var. albicans,Escherichia coli,Lacticaseibacillus rhamnosus GG,Candidatus Arthromitus sp. SFB-mouse,Escherichia coli K1,Homo sapiens,Mus musculus,gut metagenome)
• COPD pathogenesis based on metabolomic analysis (2019, Mus musculus,Rattus norvegicus,Arabidopsis thaliana,Nicotiana tabacum,Homo sapiens,Ovis aries)
• PPI network for the upregulated genes in the AMPK signaling pathway (2019, NA)
• In the absence of Hh signal, Patched1 (Ptch1) inhibits the Hh pathway through the modulation of the Smoothened (Smo) (2019, NA)
• Schematic showing that exosomes carrying miRNAs promote NDV infection (2019, NA)
• SAM on signal transduction pathways (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Hepatitis B virus,Papio hamadryas,Xenopus laevis,NA)
• Evolutionarily conserved signaling pathways (2019, NA)
• The regulation of major histocompatibility complex class I (MHC‐I) expression in non–small cell lung cancer cells by epidermal growth factor receptor (EGFR)‐MEK‐extracellular signal‐regulated kinase (ERK) signaling (2019, Homo sapiens,Bos taurus,Armoracia rusticana,NA)
• Signaling pathway nodes effected by loss of CDK11 in A375 melanoma cells following PanCancer Reactome pathways analysis (2019, NA)
• The Role of Wnt and R-spondin in the Stomach During Health and Disease (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Helicobacter pylori,Mouse mammary tumor virus)
• Metabolic reprogramming in RCC (2019, NA)
• Herpesviruses modulate the JAK-STAT pathway (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human alphaherpesvirus 2,Human alphaherpesvirus 3,Human betaherpesvirus 6,Murid gammaherpesvirus 4,Murid herpesvirus 68,Macaca mulatta rhadinovirus,Cercopithecine alphaherpesvirus 9,Homo sapiens,Saccharomyces cerevisiae,Gorilla gorilla,Saccharomyces cerevisiae IR-2,Mus musculus,Danio rerio,prion,NA)
• Expression of MALAT1 is increased in response to inflammatory stimuli in CD11c+ cells of tolerized allograft cardiac tissue (2019, Gallus gallus,Danio rerio,Human alphaherpesvirus 1,Porcine bocavirus 1,Homo sapiens,Mus musculus,Listeria monocytogenes,NA)
• Genetic mutations, HIF-1A activation and metabolism of RCC (2019, NA)
• General molecular mechanisms of metformin on inhibiting cancer cell growth (2019, Homo sapiens,Mus musculus,Syringa vulgaris)
• Illustration of how SerB2 can be secreted within macrophage cytosol to disturb immune response and cause cytoskeletal remodeling (adapted from ) (2019, NA)
• Apoptotic events (2019, Arabidopsis thaliana,Armoracia rusticana,Diaporthe sclerotioides,Stachybotrys sp.,Calcarisporium arbuscula,Paramyrothecium roridum,Myrothecium sp.,Cylindrocarpon sp.,Verticimonosporium diffractum,Calcarisporium sp.,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Proposed model for miR-130a downregulation of HCV infection (2019, NA)
• Signaling pathways underlying the potential involvement of latrophilins in growth cone and actin structures formation (2019, NA)
• Air pollution and ultraviolet radiation (UVR) on the skin (2019, Nicotiana tabacum,Oryza sativa,Diaporthe sclerotioides,Viola sororia,Homo sapiens,Mus musculus,Dipturus trachyderma,cellular organisms,Subgroup A)
• Proposed model of the C (2019, NA)
• Maize metabolic responses to Ustilago maydis infection in specific cell-types (2019, NA)
• Clinical update on head and neck cancer: molecular biology and ongoing challenges (2019, NA)
• Clinical update on head and neck cancer: molecular biology and ongoing challenges (2019, NA)
• Combating inflammation promoted by KSHV infection: KSHV infection promotes pro-inflammatory lipid mediators of arachidonic acid pathway and the enzymes involved in their synthesis (2019, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Cavia porcellus,Human gammaherpesvirus 4,Cricetulus griseus,Cricetus cricetus,Respiratory syncytial virus,Human gammaherpesvirus 8,Human betaherpesvirus 6A,Homo sapiens,Xenopus laevis,NA,NA)
• Molecular mechanisms of the cGAS/STING pathway as a senescence-associated DNA damage sensor and inflammation trigger (2019, Homo sapiens,Rattus norvegicus,Nicotiana tabacum)
• Epigenetic mediators involved in the establishment and erasure of histone post-translational modifications and DNA methylation, as described in the text (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Human papillomavirus type 16,Citrus macrophylla)
• Pathway scheme with marked involved proteins (2019, Homo sapiens,Mus musculus,Sus scrofa,Venustaconcha ellipsiformis,Artemisia vulgaris)
• UPLC-Q-TOF-MS profiling of the hippocampus reveals metabolite biomarkers for the impact of Dl-3-n-butylphthalide on the lipopolysaccharide-induced rat model of depression (2019, Glycine max,Punica granatum,Apium graveolens,Mus musculus,Rattus norvegicus,Homo sapiens,Human alphaherpesvirus 3)
• Proposed model of gga- miR-1306-5p regulation on activation of pro-inflammatory responses via targeting Tollip in chickens (Red arrow: up-regulation or down-regulation) (2019, NA)
• Synthesis of BDNF and potential downstream involved in the effects of botanicals and active components on depression (2019, NA)
• NPR-C signaling pathway (2019, NA)
• An overview of proven and hypothetical oxidative stress signaling pathways, where PP2A is involved (2019, NA)
• Preclinical Characteristics of the Irreversible Pan-HER Kinase Inhibitor Neratinib Compared with Lapatinib: Implications for the Treatment of HER2-Positive and HER2-Mutated Breast Cancer (2019, Homo sapiens)
• Canonical Wnt signaling pathway illustrating therapeutic intervention points targeted by Wnt modulators (2019, Lareunionomyces loeiensis,Artemisia annua,Homo sapiens,Mus musculus,Xenopus laevis,Mouse mammary tumor virus)
• Schematic illustration of the effects of SSE on insulin signaling and the suggested mechanism (2019, Malus domestica,Sequoia sempervirens,Sarcopoterium spinosum,Poterium spinosum,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Daphnia similis)
• Biofunction analysis of differentially expressed genes from eWAT (A) Biofunction-overlay of the disease and function related to lipolysis in eWAT; (B) the disease and function in response to CLE in eWAT (2019, NA)
• Fibroblast growth factor receptors (FGFRs) are highly conserved transmembrane receptors consisting of three extracellular immunoglobulin-like (Ig-like) domains, a transmembrane helical region, and a cytoplasmic region with kinase activity (2019, NA)
• Schematic representation of physiological and pathological aspects (major sources of oxidative stress) in Alzheimer’s disease (AD) and their corresponding antioxidant defense approach by anthocyanin in cholinergic neurons (2019, Nicotiana tabacum,Solanum tuberosum,Malus domestica,Arachis hypogaea,Curcuma longa,Camellia sinensis,Ginkgo biloba,Ipomoea batatas,Prunus domestica,Withania somnifera,Salvia officinalis,Melissa officinalis,Vitis labrusca,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• TLR4 signal pathway in oxidative stress (2019, NA)
• TLR2 signal pathway involved in oxidative stress (2019, NA)
• Sphingolipids (SLs) together with the responsible key genes involved in regulating the pathway (2019, NA)
• Graphical illustration of the proposed mode of FBXW5-induced regulation of intracellular signaling in gastric cancer (2019, NA)
• Role of Leukotriene B4 Receptor-2 in Mast Cells in Allergic Airway Inflammation (2019, NA)
• Signaling pathways and receptors involved in uveal melanoma (UM) and cutaneous melanoma (CM) (2019, Homo sapiens,Mus musculus,Danio rerio,clinical samples)
• Kinase signalling pathway (2019, NA)
• mTOR signaling in spermatozoa from older men (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Network of the sperm proteins differentially associated with male age (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Simplified scheme of the PI3K/Akt signaling pathway (2019, Olea europaea,Allium cepa,Theobroma cacao,Punica granatum,Pinus pinaster,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Triportheus paranensis)
• The interaction between Sildenafil, Leucine, PDE2, and PDE3 (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Predicted/established targets of selective flavonoids in platelets: Flavonoids modulate platelet activation through multiple mechanisms (2019, Diaporthe sclerotioides,Allium cepa,Punica granatum,Citrus limon,Cystobasidium portillonense,Justicia procumbens,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Diagram showing the different molecular mechanisms of non-canonical NLRP3 inflammasome activations (2019, NA)
• Diagram showing the different molecular mechanisms of canonical nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome activation (2019, NA)
• Proposed mechanisms for fucoidan-mediated inhibition of osteoclastogenesis (2019, Armoracia rusticana,PX clade,Phaeophyceae,Undaria pinnatifida,Sargassum hemiphyllum,Homo sapiens,Mus musculus,Bos taurus)
• Schematic representation showing phagosomal rupture-mediated phagosomal escape of MAB-R in infected murine macrophage, leading to Type I INF production via the cGAS-STING-IRF3 axis (2019, NA)
• Interactions between RHOB and EGFR, Ras, PI3K/Akt/mTOR, MYC, and HDAC (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Nicotiana tabacum)
• Scheme of copper and silver distribution in a mammalian cell (2019, Escherichia coli,Escherichia coli KD1,Methylosinus trichosporium OB3b,Escherichia coli O2H1,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Komagataella pastoris,Cinnamomum verum,Tharsalea heteronea,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio,prion)
• Mitochondrial antiviral response (2019, Mus musculus,Rattus norvegicus,Influenza A virus,Respiratory syncytial virus,Homo sapiens,prion,Thymallus thymallus,NA)
• Mechanisms underlying the anti-inflammatory effects of oxytocin (OT) on lipopolysaccharide (LPS)-stimulated microglia (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Epidermal Growth Factor Receptor-dependent activation of the MAPK signaling pathway (2019, NA)
• Neoplastic transformation of melanocyte (2019, Homo sapiens,Human alphaherpesvirus 1,clinical samples)
• Synthetic lethality of PARP-inhibitors in HR-deficient tumors (2019, Homo sapiens,Mus musculus)
• Ingenuity Pathway Analysis integrating differentially expressed genes and microRNAs between imatinib-naïve (IM-n) and imatinib-resistant (IM-r) gastrointestinal stromal tumor (GIST) samples (2019, NA)
• Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAs (2019, NA)
• PCOS–disease subnetwork 28 (2019, NA)
• PCOS–disease subnetwork 8 (2019, NA)
• PCOS–disease subnetwork 1 (2019, NA)
• IPKB analysis of relationships among upregulated genes on silk film topography (2019, Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens,Bombyx mori)
• Involvement of FGFR4-related signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Four branches of MOB control (2019, NA)
• Viral appropriation of cellular nucleocytoplasmic transport (2019, Venezuelan equine encephalitis virus,Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Dengue virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Zika virus,Human T-cell leukemia virus type I,West Nile virus,Ebola virus,Enterovirus C,Betapolyomavirus macacae,Japanese encephalitis virus,Enterovirus A71,Sindbis virus,Chikungunya virus,Lyssavirus rabies,Human adenovirus 5,Dengue virus type 2,Semliki Forest virus,Human rhinovirus sp.,SARS coronavirus NS-1,Human adenovirus sp.,human papillomavirus 11,Borna disease virus,Equine infectious anemia virus,Rhinovirus A,Woolly monkey sarcoma virus,Human adenovirus 19C,Gallus gallus,Xenopus laevis,Equus caballus,Aedes aegypti,Mustela putorius furo,Aedes albopictus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA,NA,NA,NA)
• Aberrant activation of the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma (2019, NA)
• CXCL16/CXCR6 interaction promotes endometrial decidualization via PI3K-PDK1-AKT-Cyclin D1 pathway (2019, NA)
• miRNA-223 may be an anticancer gene in NSCLC through the PI3K/AKT pathway by targeting EGFR (2019, NA)
• Biosynthesis pathway of sialylation (2019, NA)
• Proposed model illustrating the anti-IL-1B activity of matrine (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Citrus x paradisi,Porcine reproductive and respiratory syndrome virus,Ziziphus jujuba,Sophora flavescens,Porcine circovirus 2,Porcine circovirus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Convergent inflammatory signaling through NFKB potentiates BRD4-dependent transcription of VI mediators, a result suppressed by apabetalone (2019, NA)
• LUCAT1 and Wnt/beta-catenin signaling in breast cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Alocasia macrorrhizos,Human endogenous retroviruses,Renilla reniformis)
• Key components of the Hippo pathway in Drosophila and mammals (2019, NA)
• The effects of the growth factor Wnt in receptor-mediated endocytosis (micropinocytosis) and in receptor-independent endocytosis of proteins from extracellular fluids (macropinocytosis) (2019, NA)
• CaMKK2 and advanced glycation endproducts (AGEs) within the bone microenvironment (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Summary of the regulation network of Ids in heart development is shown (2019, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• GRP78 mediates hypoxia-induced EMT through smad2/3 and SRC/MAPK signaling (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Proposed model of AKAP13 and PR-B signaling in fibroids (2019, NA)
• Experimental workflow (2019, NA)
• Role of the cAMP/CREB pathway in intrinsic apoptosis (2019, NA)
• Epidermal growth factor receptor (EGFR)/EGFR variant III (EGFRvIII)-dependent biological signaling pathways (2019, Bombyx mori,Daphnis nerii,Homo sapiens,Mus musculus,Adeno-associated virus,Alburnus alburnus)
• Showing Possible effect of the mutation in leptin–leptin receptor signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• B-cell receptor pathway, which may be dysregulated in TNBC (2019, Lareunionomyces loeiensis)
• MAPK signaling pathway, which may be dysregulated in TNBC (2019, Lareunionomyces loeiensis)
• mTOR signaling pathway, which may be dysregulated in TNBC (2019, Lareunionomyces loeiensis)
• Pathway involved in gemcitabine-resistant pancreatic cancer cells with digoxin treatment (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Chaenomeles thibetica)
• TSL suppresses angiogenesis by inhibiting the VEGFR2 signaling pathway (2019, Zea mays,Diaporthe sclerotioides,Tussilago farfara,Gnetum gnemon,Homo sapiens,Mus musculus,Bos taurus)
• Metformin combined with Abs or small molecular inhibitors in cancer treatment (2019, Homo sapiens,Mus musculus,Syringa vulgaris)
• Euglena gracilis has flexible and fault-tolerant mitochondrial metabolism (2019, Euglena gracilis,Homo sapiens)
• Canonical pathways generated in Ingenuity Pathway Analysis of Oncostatin M signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi (2019, Influenza A virus,unidentified influenza virus,Ebola virus,Measles morbillivirus,Sindbis virus,Zaire ebolavirus,H5N8 subtype,Bos taurus,Capra hircus,Ovis aries,Homo sapiens,Sequoia sempervirens,NA,NA)
• Canonical pathways generated in Ingenuity Pathway Analysis of interferon signaling pathway of DEGs in (A) T helper cells, (B) T cytotoxic cells, (C) monocytes, and (D) B lymphocytes of infected goats at 9 dpi (2019, Influenza A virus,unidentified influenza virus,Ebola virus,Measles morbillivirus,Sindbis virus,Zaire ebolavirus,H5N8 subtype,Bos taurus,Capra hircus,Ovis aries,Homo sapiens,Sequoia sempervirens,NA,NA)
• PI3K/Akt/mTOR pathway activated by IL-2 and CD28 signaling and growth factors (2019, NA)
• MtDNA in activating the innate immune response (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans)
• Risk pathway interaction network from iDRW(GP) and iDRW(GMP) (2019, NA)
• Functional interaction network analysis (2019, NA)
• Pathview graph for the Kyoto Encyclopedia of Genes and Genomes term ‘calcium signaling pathway’ allows the visualization of the differentially expressed genes involved in this signaling pathway (2019, NA)
• Directed acyclic graph (DAG) of the 10 most enriched Gene Ontology (GO) terms and cytokine–cytokine receptor interaction pathways based on KEGG analysis (2019, NA)
• Regulation of immune EP expression by Tumour necrosis factor (TNF) signalling after exposure of IPEC-J2 cells to micro algae extracts in the absence and presence of ETEC (2019, Escherichia coli,Homo sapiens)
• Outline of the main altered pathways in SiNETs (2019, NA)
• Schematic highlighting the signaling cascades that are dependent on erbB4 in MPNSTs (2019, Armoracia rusticana,Diaporthe sclerotioides,Bikinia letestui,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Schematic drawing to illustrate JAK-STAT signaling pathway (2019, NA)
• Ubiquitin regulations on mTOR signaling components (2019, NA)
• Promoting immune evasion by Hippo pathway (2019, NA)
• Conceptual model of cellular processes within Tv (2019, NA)
• Platelets involvement in the pathogenesis of AAVs (2019, NA)
• PI3K/Akt signaling pathway and glucose metabolism (glycolysis, glucose uptake, nitric oxide glucose synthase, apoptosis and cell survival) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Schematic presentation of the proposed effects of melatonin against ANIT-induced intrahepatic cholestasis (2019, NA)
• Highlights of tumor metabolism (2019, NA)
• microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1 (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Nicotiana tabacum,Human gammaherpesvirus 4,Venustaconcha ellipsiformis)
• Regulatory mechanisms of Robo4 and their effects on angiogenesis (2019, NA)
• Arenaviral proteins (NP and Z) inhibit the RIG-I/MDA5 and NFKB pathways (2019, NA)
• Innate immune recognition of Chlamydia (2019, Pseudomonas aeruginosa,Helicobacter pylori,Bacteroides fragilis,Chlamydia trachomatis,Chlamydia pneumoniae,Chlamydia muridarum,Chlamydia abortus,Chlamydia caviae,Chlamydia pecorum,Chlamydia suis,Chlamydia pneumoniae AR39,Chlamydia felis,Chlamydia pneumoniae TW-183,Chlamydiales incertae sedis,Bos taurus,Sus scrofa,Ovis aries,Felis catus,Homo sapiens,Mus musculus,Cavia porcellus,Pongo pygmaeus,Gallus gallus,clinical samples)
• Neurotrophic factors and their receptors in dopamine neurons (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Macaca mulatta,Adeno-associated virus,adeno-associated virus 2,Drosophila melanogaster,unidentified)
• Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity (2019, Mus musculus,Rattus norvegicus,Vasconcellea candicans,Dioscorea alata,Homo sapiens,Oryctolagus cuniculus,Gallus gallus)
• Tumorigenic mechanisms of Fusobacterium nucleatum in colorectal cancer (2019, Fusobacterium nucleatum,Homo sapiens)
• Mitonuclear communication (2019, NA)
• Macrophage metabolic pathways (2019, Candida dubliniensis,Citrus reticulata,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Molecular mechanisms of insulin functions and associated modifications in the hypothalamus (2019, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Homo sapiens,NA)
• Schematic proposal on how toxins utilize the ER and cytosolic host factors in their transport to the cytosol in the mammalian or yeast cells (2019, NA)
• Type I and III interferon production following pathogen sensing (2019, Influenza A virus,unidentified influenza virus,Dengue virus,H5N1 subtype,Murine norovirus,Myxoma virus,Homo sapiens,Mus musculus,Antarctothoa delta,NA)
• Pathway of the EGFR-IGF1R model in lung cancer (2019, NA)
• Schematic outline of the salinity-induced response pathway based on proteome, gene expression, and physiological changes in chickpea leaves (2019, Arabidopsis thaliana,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Triticum aestivum,Hordeum vulgare,Brassica napus,Medicago truncatula,Spinacia oleracea,Pisum sativum,Medicago sativa,Phaseolus vulgaris,Prunus persica,Cicer arietinum,Vicia faba,Brachypodium distachyon,Lotus japonicus,Vigna unguiculata,Chrysanthemum x morifolium,Cajanus cajan,Glycine soja,Cynodon dactylon,Cucurbita pepo,Gossypium raimondii,Suaeda salsa,Zostera marina,Robinia pseudoacacia,Solanum chacoense,Lolium rigidum,Acanthus ebracteatus,Cynodon x magennisii,Kengyilia thoroldiana,Trifolium aureum,Halogeton glomeratus,Androctonus crassicauda,Heterometrus longimanus,Homo sapiens)
• Role of inositol in insulin signalling pathway (inspired on Larner and Brautigan) (2019, NA)
• Distinct molecular and morphologic features of apoptotic, necroptotic, and necrotic cell death (2019, NA)
• Illustration of IPO5 involvement in CRC (2019, Human papillomavirus type 16,Human gammaherpesvirus 8,Human spumaretrovirus,Homo sapiens,Mus musculus,Bos taurus,NA)
• Lipotoxicity of VLDLs on mediating maladaptation of calcium regulation to derangement of sarcomere proteins in atrial myopathy (2019, NA)
• Expressional change of genes for the central carbon metabolic network in Kmmig1 (2019, Kluyveromyces marxianus,Homo sapiens)
• Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise (2019, NA)
• Signaling pathways involved in the protective effects of tea bioactive compounds against cardiovascular diseases (2019, Nicotiana tabacum,Malus domestica,Agaricus bisporus,Camellia sinensis,Theobroma cacao,Cinnamomum verum,Mus musculus,Rattus norvegicus,Chinchilla chinchilla,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Danio rerio)
• Long non-coding RNA acting within the NODAL signalling pathway (2019, NA)
• Main energy metabolism and carbon/nitrogen fluxes in heterocysts (2019, NA)
• Reconstructed key metabolic pathways of Thermoprofundales based on eight MAGs (a) (2019, metagenome,metagenomes,activated sludge metagenome,uncultured bacterium Of10,uncultured archaeon,uncultured bacterium Of13,uncultured bacterium Of23,Pyrococcus furiosus,Thermoplasmatales archaeon,Thermoplasma volcanium GSS1,Thermoplasmatales archaeon SM1-50,Thermoplasmatales archaeon SG8-52-4,Candidatus Thermoprofundales,Erythrina poeppigiana,Plantago princeps,Quercus alba,Anas acuta,Homo sapiens)
• Functional enrichment and gene network analysis (2019, Danio rerio,Triportheus paranensis,Homo sapiens,Mus musculus,Hordeum vulgare)
• Proposed mechanism of the p75NTR as a mediator of synaptic changes during SD (2019, Mus musculus,Homo sapiens)
• Pericytes contribute in homeostasis of the BBB through different mechanisms (2019, NA)
• Molecular mechanism underlying the promoting roles of the expression of CSE on the progression of breast cancer (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Punica granatum,Homo sapiens)
• General summary of the NBP-involved cellular signal pathway in (a) cancer cell proliferation, migration, and apoptosis and in (b) stem cell differentiation (2019, NA)
• Molecular regulators and signalling mechanisms involved in the activation of astrocytes (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• NRF2 acts as a central hub to facilitate the transition of BCSCs from the M to E state as well as the maintenance/proliferation of E-BCSCs under metabolic/oxidant stress (2019, NA)
• Under pathologic circumstances, pericytes present stemness or trans-differentiation potential (2019, NA)
• Pathway Map of Glioblastoma obtained from Wikipathways using Cytoscape (2019, Homo sapiens,Mus musculus,Caenorhabditis elegans,Nicotiana tabacum)
• Relationships among Gal-1, MAPK JNK/p38 signalling pathway and EMT (2019, NA)
• Pathway-based analysis for glycolysis, TCA cycle and pentose phosphate pathway (2019, Escherichia coli,Mycobacterium tuberculosis,Escherichia coli O2H1,Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Pathways to B cell memory (2019, NA)
• Signaling crosstalk at the IKB module (2019, Homo sapiens,Mus musculus,Candida dubliniensis,Aggregatibacter actinomycetemcomitans)
• Signaling crosstalk at receptors and adaptors (2019, Homo sapiens,Mus musculus,Candida dubliniensis,Aggregatibacter actinomycetemcomitans)
• NFKB signaling pathway (2019, Homo sapiens,Mus musculus,Candida dubliniensis,Aggregatibacter actinomycetemcomitans)
• Pathogen-Responsive NFKB (2019, Homo sapiens,Mus musculus,Candida dubliniensis,Aggregatibacter actinomycetemcomitans)
• Differentially expressed miRNAs in thyroid cancer tissues modulating the PI3K pathway (2019, Homo sapiens,Mus musculus)
• Differentially expressed miRNAs in thyroid cancer tissues modulating the MAPK pathway (2019, Homo sapiens,Mus musculus)
• Signaling pathways involved in Alpha-CGRP-induced vasodilation (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Castor fiber,Diaporthe sclerotioides,Allium tricoccum,Homo sapiens,Oryctolagus cuniculus)
• Alpha-CGRP-mediated intracellular signaling (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Castor fiber,Diaporthe sclerotioides,Allium tricoccum,Homo sapiens,Oryctolagus cuniculus)
• Antioxidant mechanism of the NRF2 pathway (2019, NA)
• Selective Autophagy degrades cell cycle proteins (2019, NA)
• Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Drosophila melanogaster,Leishmania donovani,Homo sapiens,Saccharomyces cerevisiae,Dengue virus)
• Models for potential interaction between Toll-like receptor 4 (TLR4) and protease-activated receptor 2 (PAR2).(A) Direct interaction at the plasma membrane model (2019, NA)
• PD-1 signaling in B cells and T cells (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Mus musculus,Helicobacter pylori,Carassius auratus,Cryptosporidium parvum)
• Therapeutic strategies targeting NAMPT against stroke (2019, NA)
• Biosynthetic pathway of ginsenosides according to (2019, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Malus domestica,Panax ginseng,Vitis vinifera,Fragaria x ananassa,Salvia miltiorrhiza,Ginkgo biloba,Artemisia annua,Petroselinum crispum,Morus alba,Andrographis paniculata,Panax quinquefolius,Taxus chinensis,Picrorhiza kurrooa,Freesia alba,Onosma paniculata,Magnolia chapensis,Escherichia coli,Escherichia coli DH5alpha,Escherichia coli IS1,Schaalia meyeri,Homo sapiens)
• Differentially expressed genes in p53 signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus,clinical samples)
• TLR4-mediated inflammatory signaling pathway in the rumen epithelium (2019, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Sequoia sempervirens,Foot-and-mouth disease virus,Phleum pratense,Bovine viral diarrhea virus 1,Mycobacterium tuberculosis variant bovis,Pollachius virens,Homo sapiens)
• Intestinal disease-related pathway including MAPK signaling pathway, NF-kappa B signaling pathway, calcium signaling pathway, and chemokine signaling pathway (2019, Diaporthe sclerotioides,herbal medicine,Panax ginseng,Glycyrrhiza uralensis,Wolfiporia cocos,Platycodon grandiflorus,Atractylodes macrocephala,Cystobasidium portillonense,Dioscorea oppositifolia,Lablab purpureus,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Ruminococcus gnavus,Blautia sp.,Blautia stercoris,Blautia faecis,Mus musculus,Rattus norvegicus,Meleagris gallopavo,Molva molva,Homo sapiens,Sus scrofa,gut metagenome,Coxsackievirus)
• Bt-resistance mechanisms in target pests (2019, NA)
• Signaling network of the MSC components related to protein synthesis and cancer (2019, NA)
• The roles of circRNAs in cancer phenotypes and biological characteristics (2019, NA)
• CK2 actions on chaperone machinery (a), NFKB signaling (b), and PI3K/AKT/PTEN pathway (c) (2019, NA)
• POL-P3b-induced protection against tumor-induced intestinal DC apoptosis through the cross talk between TLR4/PI3K/AKT and NFKB signaling pathway (2019, NA)
• Mechanisms of ionizing radiation sensitizing and resistant effects in various subtypes of breast cancer and irradiation-induced apoptosis (2019, NA)
• Pathway map based on renal age-associated gene (RAAGs).Enriched molecular pathways based on the set of 634 RAAGs are displayed (2019, Homo sapiens,Mus musculus,Bos taurus)
• Hypothesis of the mechanism of IDH mutant gliomas (2019, Homo sapiens,Bos taurus,clinical samples,Venustaconcha ellipsiformis)
• The mutIDH1 and mutIDH2 pathways and molecular mechanisms related to oncogenesis (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Ciliary TGFB/BMP signalling (2019, Drosophila melanogaster,Caenorhabditis elegans,Trypanosoma brucei,Paracentrotus lividus,Tetrahymena thermophila,Gallus gallus,Danio rerio,Xenopus laevis,Lareunionomyces loeiensis,Chlamydomonas reinhardtii,Sesamum indicum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Phospholipid and TG synthesis pathway (2019, NA)
• Lipid biosynthesis in cancer cells (2019, NA)
• Systematic association of the MSC components with mTOR and DNA repair pathways (2019, NA)
• Comparative RNA-seq analysis reveals dys-regulation of major canonical pathways in ERG-inducible LNCaP cell progression model of prostate cancer (2019, NA)
• Emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications (2019, Human betaherpesvirus 5,Murid betaherpesvirus 1,Human herpesvirus 5 strain Towne,Homo sapiens,Mus musculus,Eucalyptus intertexta,NA)
• Anti-pancreatic cancer pathway of Wumei Pill (2019, NA)
• Schematic and simplified representation of the several components of the IGF-1/PI3K/AKT/mTOR pathway discussed in this review (2019, Homo sapiens,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Mus musculus,Bos taurus)
• HBP regulates multiple proteins in cancer cells via OGT (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Triportheus paranensis,Moloney murine leukemia virus)
• Hexosamine biosynthetic pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Triportheus paranensis,Moloney murine leukemia virus)
• miRNA-26a-5p Accelerates Healing via Downregulation of PTEN in Fracture Patients with Traumatic Brain Injury (2019, NA)
• Transcriptional effects in zebrafish liver after feeding with 25% of maize substitution (2019, Danio rerio,Triportheus paranensis,Oncorhynchus mykiss,Salmo salar,Oreochromis niloticus,Dicentrarchus labrax,catfish,Sparus aurata,Pagrus pagrus,Perca fluviatilis,Rhamdia quelen,Zea mays,Glycine max,Triticum aestivum,Pisum sativum,Homo sapiens,Bos taurus,Bacillus thuringiensis,Artemia salina)
• Schematic summary of molecular pathways induced by HBx-B genes (2019, NA)
• Mechanisms by which bacteria influence cancer development and progression (2019, NA)
• The MEK5–extracellular signal-regulated kinase 5 (ERK5) pathway with activators and downstream effectors (2019, Homo sapiens,Mus musculus,Glycine max)
• TRAFs in IL-17 signaling pathway (2019, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Ovis aries)
• FGFRs signaling pathway could be elicited by FGFs with the existence of heparin (2019, NA)
• Figure illustrates the signal transduction cascades of TGF/BMP, Wnt, Hedgehog signaling pathway in the development of cranial sutures (2019, NA)
• Release of mitochondrial proteins and mtDNA initiates an inflammatory response in CICD (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Model illustrating potential effects of cold stress on membrane lipid pathway in peanut (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Arachis hypogaea,Brassica napus,Aspergillus niger,Saccharum officinarum,Gossypium hirsutum,Brassica rapa subsp. pekinensis,Paeonia lactiflora,Saccharomyces cerevisiae CAT-1,Chenopodium quinoa,Mimosa pudica,Candida pruni nom. inval.,Rhodotorula glutinis,Medicago falcata,Eutrema salsugineum,Crambe hispanica subsp. abyssinica,Triadica sebifera,Descurainia sophia,Bambusa emeiensis,Homo sapiens,Escherichia coli,Erebia epipsodea)
• Possible mechanism of matrine on inhibiting skeletal muscle atrophy (2019, Bos taurus,Equus caballus,Sophora flavescens,Parthenium integrifolium,Homo sapiens,Mus musculus,Danio rerio,clinical samples)
• ERK1/2 and p38 MAPK-CREB-mediated GM-CSF secretion (2019, NA)
• Suppressive mechanism of regulatory T (Treg) cells (2019, NA)
• IFITM3 promotes bone metastasis of prostate cancer cells by mediating activation of the TGFB signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,unidentified influenza virus,Homo sapiens,Escherichia coli,Armoracia rusticana,vectors)
• Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFKB—IL-6 signalling axis (2019, Human papillomavirus,Human papillomavirus type 16,Merkel cell polyomavirus,human papillomavirus 18,Homo sapiens,Mus musculus,Bos taurus,clinical samples,murine stem cell retroviral vector,NA)
• Drugs targeting Wnt/beta-catenin signaling in Desmoid-Type Fibromatosis (2019, NA)
• Regulation of the mucus production by MAPK signalling (2019, NA)
• Regulatory mechanisms of macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor kappa B, ligand (RANKL) induced osteoblast differentiation and survival (2019, NA)
• Complement pathways (2019, NA)
• Cytosolic glucose enters glycolysis and pentose phosphate pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Argentina sphyraena)
• Comparative proteomic study reveals the enhanced immune response with the blockade of interleukin 10 with anti-IL-10 and anti-IL-10 receptor antibodies in human U937 cells (2019, NA)
• Implication of various approaches employed by host-mediated resistance factors in defense against geminiviruses (2019, NA)
• Consequence of post-translational modification of viral and host proteins during geminiviral pathogenesis (2019, NA)
• Snapshot of trastuzumab resistance pathway (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,clinical samples)
• STING pathway activation in DNA repair deficient breast cancer (2019, Homo sapiens,Mus musculus)
• Protein-protein interaction network complex and modular analysis (2019, NA)
• Herbal medicines promote the activation of the HIF-1 pathway through different targets in ischemic stroke (2019, NA)
• Chinese herbal medicines inhibit the activation of the HIF-1 pathway in cancer treatment through different targets (2019, NA)
• Temporal changes in the transcriptome related to the central metabolic pathway in a synchronized C (2019, Cyanidioschyzon merolae,Homo sapiens)
• Mec1/Rad53 pathway senses ongoing DNA replication to inhibit mitotic entry (2019, Saccharomyces cerevisiae,Homo sapiens)
• Possible antifibrotic mechanism of exogenous hydrogen sulfide in diabetic cardiomyocytes (2019, NA)
• Helper T cell differentiation and HBP (2019, NA)
• Oncogenic activation of MAPK pathway (2019, NA)
• TLR2/IFN-λ3 protein-protein interaction was performed by using String software (2019, Homo sapiens,Pan troglodytes,Mus musculus,Hepatitis B virus,NA)
• Schematic depiction of the major pathways involved in signaling through the ALK-MYCN axis in neuroblastoma (NB) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Acute phase response (APR) is central to the FL induced response in skin, brain, and liver of all three model organisms (2019, NA)
• Proposed model relating canonical and non-canonical Wnt signaling with teneurin-3 expression (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster)
• Leptin metabolism pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Ovis aries,unidentified)
• Probable mechanisms of the effects produced by lncRNAs on TBI.Notes: There are several lncRNAs that have been reported to play different roles in the process of TBI (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model for role of MARK4 in regulating lipogenesis in pig placental trophoblast cells (2019, NA)
• Tangeretin-induced apoptotic pathway in BFTC-905 bladder cancer cells (2019, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Citrus sinensis,Piper betle,Mus musculus,Rattus norvegicus,Homo sapiens,Calloplesiops altivelis,Sarcophyton crassocaule)
• Schematic illustration of the proposed model depicting a p53/miR-27a/NFAT5 mediated regulatory pathway in mouse GCs (2019, NA)
• Schematic map describing apoptosis induction of the TRAIL and Andro combination therapy (2019, Bos taurus,Oryctolagus cuniculus,herbal medicine,Andrographis paniculata,Homo sapiens,Mus musculus,Papaya ringspot virus)
• NLRP3 inflammasome pathways and putative mechanism by which cyclic stretch negatively regulates IL-1B secretion in murine macrophages (2019, NA)
• Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial (2019, NA)
• MUC17 inhibits the progression of human gastric cancer by limiting inflammatory responses (2019, NA)
• Isobutanol biosynthesis pathway in yeast S (2019, NA)
• Ang-II induced cardiac fibrosis mediated by periostin (2019, NA)
• Fanconi anemia curated map, based in the KEGG FA pathway (2019, NA)
• Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways (2019, NA)
• Methyltransferases linked to regulation of autophagy (2019, Homo sapiens)
• Differentially expressed genes were labeled in the proteoglycans in cancer pathway in the placenta after IVF-ET during the first trimester by KEGG (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Diaporthe sclerotioides,Helicobacter pylori,Ovis aries)
• Pathway schematic of the effect of paeoniflorin on TGFB1/Smads signaling pathway in chronic heart failure rats (2019, Rattus norvegicus,Homo sapiens)
• Diagram of ellagic acid target proteins from the DrugBank database (2019, Armoracia rusticana,Punica granatum,Vitis rotundifolia,Alchemilla vulgaris,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Outline of potential mechanism of sEH inhibition-stabilized EETs in inhibiting colonic adenoma—carcinoma sequence via targeting inflammation and its activated Wnt/mutant p53 signals (2019, NA)
• Outline of the potential mechanism of sEH inhibition-stabilized EETs in blocking NSAID-induced GI ulcers (2019, NA)
• IL-1F family signaling complexes (2019, NA)
• ROS involved in vegetative apical meristem identity in the shoot apical meristem (2019, NA)
• Diagram summarizing the role of glia connexin changes in demyelinating disorders (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• illustrates the contractive and proliferative role of increased [Ca2+]i in PAH PASMC (2019, NA)
• Comprehensive pathway of Alzheimer’s disease derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,prion)
• Proposed schematic mechanism of EBV-associated gastric carcinogenesis via the activation of the PI3K/AKT/mTOR pathway, and its blockade by CMG002 (2019, NA)
• Gene-pathway network of 26 DEGs (2019, Influenza A virus,Measles morbillivirus,Felid alphaherpesvirus 1,Homo sapiens,Cereibacter sphaeroides)
• JAK2-STAT5-SOCS pathway and domain structure of STAT5 (2019, NA)
• KEGG pathways enriched by the differentially expressed mRNAs in the competing endogenous RNA network (2019, Homo sapiens,Candida dubliniensis,clinical samples)
• Proposed mechanisms of action of glutamatergic modulators and other putative rapid-acting antidepressants (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model of OLFM4‐induced STAT3 activation mediated by the LGR5‐Wnt signaling pathway in HCC (2019, NA)
• Gradient-triggered activation of the cAMP-dependent pathway controls signaling from stimulatory G protein-coupled receptors (2019, NA)
• Wnt signaling pathway (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Pseudomonas aeruginosa)
• Decidual RANKL/RANK interaction promotes the residence and polarization of TGFB1-producing regulatory GD T cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Hepatitis B virus)
• Identification of gene signature and critical pathway associated with childhood-onset type 2 diabetes (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mitochondria-mediated apoptotic signaling pathway by JNK and p38 (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Mechanism by which EPD attenuates IMQ-induced psoriasis by inhibiting the inflammation responses via TLR7/8–MyD88–NFKB–NLRP3 inflammasome signaling pathways (2019, Vasconcellea candicans,Cullen corylifolium,Physalis peruviana,Datura metel,Mus musculus,Bos taurus,Oryctolagus cuniculus,Cricetulus griseus,Homo sapiens,Opsanus beta)
• Agent that activates the cascade in the MAPK pathway, which can lead to TJs opening or assembly (2019, NA)
• Proposed divergent role of Notch signaling in endothelial and smooth muscle cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Possible role of DhHP-6 in type 2 diabetes experimental model (2019, Mus musculus,Rattus norvegicus,Siraitia grosvenorii,Rosa roxburghii,Homo sapiens,Bos taurus,Caenorhabditis elegans,Triportheus paranensis,Bifidobacterium pseudocatenulatum)
• Proposed 5-HT1A receptor-mediated signaling pathway through which mGlu2/3 receptor antagonists and ketamine exert their antidepressant effects (2019, NA)
• Upon T-cell receptor (TCR) signaling, the protein arginine methyltransferase PRMT5 interacts with DUSP14 and induces its methylation on Arg17, Arg38, and Arg45 residues (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,gut metagenome)
• Cell migration elicited by chemotactic GPCRs via the GBG–P-REX1–Rac pathway is mainly mediated by Gi over Gq or G13 because of the tight control that GAq and GA13 subunits exert on GBG (2019, NA)
• Skeletal muscle insulin signalling (2019, NA)
• Schematic pathway predicting the role of sodium acetate-induced genes in G (2019, NA)
• Signal Exchange through Extracellular Vesicles in Neuromuscular Junction Establishment and Maintenance: From Physiology to Pathology (2019, NA)
• Molecular mechanisms of alcohol-induced apoptosis and autophagy in hepatocytes (2019, NA)
• Leptin receptor signaling is mediated by JAK-STAT, PI3K-Akt, and SHP2-ERK pathway (2019, Mus musculus,Helicobacter pylori,Meriones unguiculatus,Helicobacter felis,Homo sapiens,Entamoeba histolytica)
• Regulation and role of the PI3K-AKT-mTORC1 pathway in ribosome biogenesis and translation initiation (2019, NA)
• Major phenotypic responses in activated, myofibroblast-like cells (HSC/MFs) as well as, more generally, in hepatic MFs (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• Mitogen-activated protein kinase (MAPK) cascades in activated, myofibroblast-like hepatic stellate cells (HSC/MFs) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• Targeting the TGFB signaling pathway in cancer (2019, NA)
• TGFB mediates metastasis (2019, NA)
• TGF-Beta-induced growth inhibition and apoptosis (2019, NA)
• TGFB/SMAD and non-SMAD signaling (2019, NA)
• Survival signaling pathways related to the PI3K/Akt pathway in mouse macrophages (2019, NA)
• Metabolic and signaling pathway crosstalk in tissues of animals with high inherent aerobic capacity (HIAC) and animals with low inherent aerobic capacity (LIAC) (2019, Homo sapiens,Rattus norvegicus,Venustaconcha ellipsiformis)
• Role of the RAS and the hexosamine biosynthetic pathways in DCM (2019, NA)
• IL-6–JAK/STAT–SOCS3 signalling pathway (2019, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens)
• Pathogenic mechanisms of hyperglycemia through the production of AGEs (2019, NA)
• Glycolysis/gluconeogenesis pathway (2019, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Triticum aestivum,Brassica napus,Medicago sativa,Gossypium hirsutum,Citrus sinensis,Vigna radiata,Capsicum frutescens,Morus alba,Cajanus cajan,Populus nigra,Lolium multiflorum,Kalanchoe daigremontiana,Lactococcus lactis,Pseudomonas putida KT2440)
• Ubiquitination-monitored regulation of the Wnt/Beta-Catenin pathway in colorectal cancer (CRC) cells (2019, NA)
• Genomic correlates of response to immune checkpoint blockade (2019, Human papillomavirus,Polyomavirus sp.,Homo sapiens,Mus musculus,gut metagenome)
• TRAFs in TLR signaling pathways (2019, NA)
• Nrf2 signaling in homeostasis and a deregulated environment (2019, NA)
• Simplified schematic illustration of pathways for Wnt/Beta-catenin, ERK/MAPK and PI3K/Akt and PGE2-metabolism (2019, Homo sapiens)
• Regulatory role of GRK2 in TLRs-mediated signaling pathways for iNOS expression in microglial cells (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Signaling pathway downstream of TLR4 receptor in platelets with related cellular events and their regulatory miRNAs* (2019, NA)
• Simplified schematic representation of the affected pathways in an emerging honeybee worker that impact Varroa and DWV symptoms via their interactions (2019, Varroa destructor,Homo sapiens)
• Antioxidant signaling pathway regulated by quercetin (2019, NA)
• Label propagation defines signaling networks associated with recurrently mutated cancer genes (2019, NA)
• Cooperation of 17-aminogeldanamycin (AG) and trametinib (TRA) or vemurafenib (PLX) a A schematic summary of molecular effects of TRA, and PLX activity, and 17-aminogeldanamycin-mediated HSP90 inhibition in melanoma cells (2019, NA)
• Essential metabolism and mitochondrial regulation on B cells (A) and Antibody-Secreting Cells (B) (2019, NA)
• Immature and mature neutrophils have different metabolic requirements (2019, NA)
• Wnt signaling pathways and the intervention targets of Wnt pathway inhibitors (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis)
• Current model of iron sensing in the liver to regulate hepcidin production (2019, NA)
• Illustration depicting primary signalling mechanisms of different neuronal and astrocytic proteins encoded by genes implicated in ID/ASDs (2019, NA)
• Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway (2019, NA)
• The effects of polyphenols on signaling pathways in prostate cancer (2019, Homo sapiens)
• Apoptosis can be modulated by the activity of polyphenols in prostate cancer (2019, Homo sapiens)
• Schematic diagram showing the critical role of FDPS in normal prostate and prostate cancer and its associated potential mecahnism (s) (2019, NA)
• Molecular signaling pathway of TNFR2 (2019, NA)
• Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation (2019, Plasmodium falciparum,Homo sapiens)
• The major mechanisms involved in the response of the Vitis flower to a cold night (2019, Arabidopsis thaliana,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Malus domestica,Panax ginseng,Vitis vinifera,Brassica napus,Camellia sinensis,Spinacia oleracea,Brassica oleracea,Pisum sativum,Phaseolus vulgaris,Gossypium hirsutum,Ipomoea batatas,Glycine soja,Vitis amurensis,Tamarix hispida,Pinus densiflora,Paraboea rufescens,Escherichia coli,Paraburkholderia phytofirmans PsJN,Paraburkholderia phytofirmans,unidentified)
• Compound-target network of 3DC2ME (2019, NA)
• mTORC1 as a key hub transducing the metabolic effects of glucose and fructose in the liver (2019, NA)
• Major mechanisms regulated by SUMOs and SUMOylation in kidney disease (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• LINC00520 suppresses EGFR expression and inactivates the PI3K/Akt signaling pathway, thereby suppressing cSCC migration, invasion and metastasis (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• AMPK integration of energy stress shapes mTORC1 activity at the lysosome (2019, Escherichia coli,Listeria monocytogenes,Bacillus anthracis,Escherichia coli MP1,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,NA)
• PKM2: Junction of Metabolic Networks and Signal Cascades (2019, NA)
• Signaling pathway and inhibitors of inflammasomes (2019, NA)
• The proposed mechanisms by which norepinephrine (NE) and corticosterone/cortisol (CORT) regulate sterile inflammation (2019, NA)
• Signaling pathway (2019, NA)
• TPO receptor pathway (2019, Homo sapiens)
• Other fatty acid metabolism targets (2019, NA)
• Tumor- and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures (2019, NA)
• Endoplasmic reticulum (ER) stress signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus)
• Autophagy signaling pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus)
• Potential proinflammatory role of resistin in the pathogenesis of osteoarthritis (2019, NA)
• Dysregulated immune response in the primary mediastinal B‐cell lymphoma (PMBCL) tumour microenvironment (2019, NA)
• Schematic depiction (2019, NA)
• Model describing the mechanism regarding the inhibitory effect of IFITM2 on Type I IFN signaling pathway (2019, Hepatitis B virus,Human alphaherpesvirus 1,Dengue virus,H1N1 subtype,West Nile virus,Myxoma virus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,NA)
• Molecular mechanisms for renoprotection of EGCG (2019, NA)
• Possible pathways underlying the DLL1/Notch signaling pathway defect (2019, Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis,Dipturus trachyderma)
• Dual aspects of GM-CSF immunomodulatory effects (2019, NA)
• GM-CSF in MS pathogenesis (2019, NA)
• T-cell receptor (TCR) signaling (2019, NA)
• Curcumin mediated inhibition of cell growth via inhibition of AKT signaling and activation of mitochondrial apoptotic pathway (2019, Homo sapiens,Calloplesiops altivelis,Iberis amara)
• Ligand-independent and ligand-dependent transactivation of epidermal growth factor receptor (EGFR)/MAPK3/1 pathway in pig cumulus cells by FSH (2019, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Matthiola incana,Pieris brassicae)
• Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness (2019, NA)
• Purinergic signaling complex (2019, Homo sapiens)
• Mutations of the MAPK/TSC/mTOR pathway characterize periventricular glioblastoma with epithelioid SEGA-like morphology–morphological and therapeutic implications (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Association between high glycolytic flux and extracellular pH (pHe) gradient formation by carbonic anhydrase, as well as proton pump and exchangers (2019, NA)
• Coordinated interactions between glycolysis, citrate cleavage enzyme, and glutaminolysis for the fatty acids biosynthesis in growing tumor cells (2019, NA)
• Connections between the cAMP/PKA pathway and virulence-related functions in C (2019, Cryptococcus neoformans,Homo sapiens)
• CAMP/PKA pathway in C (2019, Cryptococcus neoformans,Homo sapiens)
• CAMP/PKA pathway in S (2019, Cryptococcus neoformans,Homo sapiens)
• Potential mechanisms underlying EOC chemoresistance and the sensitizing effect of PI3K inhibition (2019, NA)
• Network of the cellular thiol redox system in multicellular eukaryotes (2019, NA)
• Integration of TRP channel involvement in mechanotransduction-associated mechanisms during cell migration (2019, NA)
• Schematic presentation of PI3K-Akt intracellular signaling (2019, NA)
• Inflammasome regulatory network (2019, Human endogenous retroviruses,Human endogenous retrovirus,Homo sapiens)
• Possible underlying mechanism of PAR4 signaling (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Phosphorylation of cofilin and actin cytoskeleton rearrangement induced by gliotoxin during A (2019, NA)
• Mechanisms promoting regulatory T cell (Treg) development and immunosuppression in the tumor microenvironment (2019, NA)
• Schematic diagram for anti-ethanol caused damage in K (2019, NA)
• Nuclear gene-encoded regulatory factors are essential for mitochondrial biogenesis and function (2019, NA)
• Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Simplified figure depicting the roles of RORC consensus pathway members, adapted from Yu et al (2019, Staphylococcus aureus,Streptococcus pyogenes,Homo sapiens,Mus musculus,Human T-cell leukemia virus type I,Candida albicans 23R)
• WNT signaling model (2019, Homo sapiens)
• Intensity of the stimulus that induces DNA damage and the degree of activation of PARP1 determines the fate of a cell toward survival or death (2019, NA)
• Japanese encephalitis virus (JEV) intracellular effect mechanism (2019, NA)
• Signal transduction pathway related to the immune-regulation of botanical polysaccharides in macrophage activation (2019, Saccharomyces cerevisiae,Nicotiana tabacum,Triticum aestivum,Panax ginseng,Salvia miltiorrhiza,Ipomoea batatas,Panax notoginseng,Angelica sinensis,Lycium barbarum,Chlorella vulgaris,Aloe vera,Dendrobium officinale,Platycodon grandiflorus,Lentinula edodes,Hippophae rhamnoides,Populus tomentosa,Moringa oleifera,Citrus unshiu,Ophiopogon japonicus,Leymus chinensis,Cucurbita moschata,Sargassum fusiforme,Rosa rugosa,Tinospora cordifolia,Aconitum carmichaelii,Cistanche deserticola,Eutrema salsugineum,Parachlorella kessleri,Ganoderma atrum,Ganoderma sinense,Limonium bicolor,Dictyophora indusiata,Ganoderma formosanum,Basella alba,Spondias dulcis,Aegilops markgrafii,Curcuma xanthorrhiza,Bupleurum smithii,Rhynchosia minima,Alchornea cordifolia,Genista tridentata,Baeomyces lotiformis,Pteris ensiformis,Ixeris polycephala,Thamnolia vermicularis,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Human immunodeficiency virus 1,NA)
• Mechanism of progesterone actions (2019, NA)
• Immunosuppressive effect of the tumor microenvironment (2019, NA)
• Wnt, Beta-catenin. and PCP signaling (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Daucus carota)
• Telomerase regulation and telomere elongation pathway (2019, NA)
• TGFB signaling pathway regulated autophagy and EMT (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• PKA actives CREB (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Inhibition of Cyclin‐Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy (2019, NA)
• Dorsal root ganglion (DRG) neurons branch out to the skin with transient receptor potential channel vanilloid 1 (TRPV1)/transient receptor potential channel ankyrin transmembrane protein 1 (TRPA1) and other receptors expressing (2019, NA)
• Interaction network formed by the encoded proteins of genes showing P values of potential relevance in our study (P < 1 × 10−4), according to the presence/absence of carotid plaques (2019, NA)
• Pheromone response and negative feedback (2019, NA)
• Schematic illustration of the interleukin (IL)-12/IL-23 pathway (2019, Homo sapiens)
• Characterization of complex transporter-mediated model of carbon allocation and energy supply for oil synthesis in developing P (2019, NA)
• Proposed model of regulation of endothelial barrier function by FBXW7 (2019, NA)
• Generalized Lymphatic Anomaly and Gorham–Stout Disease: Overview and Recent Insights (2019, NA)
• Generalized Lymphatic Anomaly and Gorham–Stout Disease: Overview and Recent Insights (2019, NA)
• Phytochemicals Targeting VEGF and VEGF-Related Multifactors as Anticancer Therapy (2019, NA)
• Schematic model of CCI in inducing the activation of microglia and NP (2019, NA)
• Explanations of impaired effect of tolerogenic DCs in vaccine generated from patients with chronic hyperglycemia (2019, Homo sapiens,Mus musculus,Plantago princeps)
• Pathway map of Notch signaling (A) and Th1 differentiation (B) in KEGG (2019, Danio rerio,Oncorhynchus mykiss,teleost fish,Cyprinus carpio,Carassius auratus,Salmo salar,Salmo trutta,Oreochromis niloticus,Ctenopharyngodon idella,Paralichthys olivaceus,Ictalurus punctatus,Dicentrarchus labrax,Epinephelus coioides,catfish,Larimichthys crocea,Scophthalmus maximus,Pagrus pagrus,Anser sp.,Cynoglossus semilaevis,Oreochromis mossambicus,Lates calcarifer,Siniperca chuatsi,Tachysurus fulvidraco,Micropterus salmoides,Cyprinus carpio color,Megalobrama amblycephala,Carassius gibelio,Lateolabrax japonicus,Mugil cephalus,Notothenia coriiceps,Acipenser schrenckii,Hypophthalmichthys molitrix,Miichthys miiuy,Argyrosomus japonicus,Tor putitora,Trachinotus blochii,Planiliza affinis,Pampus argenteus,Coregonus lavaretus,Seriola lalandi,Epinephelus lanceolatus,Lutjanus campechanus,Cottus gobio,Tachysurus vachellii,Lutjanus sanguineus,Epinephelus fuscoguttatus,Planiliza haematocheilus,Schizothorax prenanti,Paralichthys lethostigma,Culter alburnus,Seriola dumerili,Coregonus palaea,Misgurnus mizolepis,Escherichia coli,Pseudomonas fluorescens,Francisella tularensis,Aeromonas hydrophila,Streptococcus agalactiae,Vibrio parahaemolyticus,Vibrio harveyi,Vibrio anguillarum,Edwardsiella tarda,Vibrio alginolyticus,Aeromonas salmonicida,Yersinia ruckeri,Flavobacterium columnare,Piscirickettsia salmonis,Lactococcus garvieae,Streptococcus dysgalactiae,Aeromonas veronii bv. sobria,Aeromonas hydrophila subsp. hydrophila,Nocardia seriolae,Aeromonas sobria,Reovirus sp.,Grass carp reovirus,Isavirus salaris,Sprivivirus cyprinus,Lymphocystis disease virus 1,Striped jack nervous necrosis virus,Mus musculus,environmental samples,NA,Homo sapiens)
• Proposed cell death mechanism (2019, Armoracia rusticana,Fragaria x ananassa,Vasconcellea candicans,Nigella sativa,Phytolacca americana,Prunella vulgaris,Prunella vulgaris var. lilacina,Pleiocarpa pycnantha,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Human papillomavirus type 16)
• Brief summary of reciprocal regulation between AMPK and mTOR pathways (2019, NA)
• NLRP3 inflammasome pathway (2019, NA)
• MET protein structure (a) and HGF/MET signaling pathway (b) (2019, NA)
• AMPK-mTOR signaling pathways during Mtb infection (2019, NA)
• Metabolic network of Pseudomonas species (2019, Escherichia coli,Pseudomonas aeruginosa,Escherichia coli K-12,Klebsiella pneumoniae,Pseudomonas syringae,Pseudomonas putida,Pseudomonas fluorescens,Pseudomonas aeruginosa PAO1,Pseudomonas putida KT2440,Stutzerimonas stutzeri,Pseudomonas chlororaphis,Pseudomonas protegens Pf-5,Pseudomonas protegens CHA0,Pseudomonas oleovorans,Pseudomonas syringae pv. syringae B728a,Pseudomonas aeruginosa UCBPP-PA14,Pseudomonas extremaustralis,Pseudomonas aeruginosa DK2,Pseudomonas aeruginosa LESB58,Escherichia coli PA23,Pseudomonas extremaustralis 14-3,Pseudomonas aeruginosa SJTD-1,Pseudomonas aeruginosa RP73,Pseudomonas aeruginosa c7447m,Pseudomonas aeruginosa PACS2,Pseudomonas aeruginosa AES-1R,Pseudomonas extremaustralis 14-3 substr. 14-3b,Pseudomonas mediterranea CFBP 5447,Pseudomonas aeruginosa MTB-1,Pseudomonas aeruginosa SCV20265,Pseudomonas aeruginosa YL84,Armoracia rusticana,Solanum lycopersicum,Diaporthe sclerotioides,Fulvia fulva,Homo sapiens,Oryctolagus cuniculus)
• T cells are differentiated into multiple T cell subtypes including Th1, Th2, T-fh, Th17 and T-reg cells (2019, Homo sapiens,Rattus norvegicus)
• Regulation of immunometabolism in macrophages infected with Mtb (2019, NA)
• Cytochrome b5 Is an Obligate Electron Shuttle Protein for Syringyl Lignin Biosynthesis in Arabidopsis (2019, Arabidopsis thaliana,Magnoliopsida)
• Schematic model of intracellular signaling mechanisms regulating proteasome inhibitor-induced apoptosis by FLT3-ITD involving the STAT5/Pim axis and the mTORC1/eIF4F/Mcl-1 pathway (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Ras-cAMP/PKA Pathway in yeast and mammalian cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Heme activator proteins (HAP) complex (2019, Saccharomyces cerevisiae,Homo sapiens)
• Speculated antioxidant related signaling pathways induced by APS in MEFs (2019, Armoracia rusticana,Malus domestica,Olea europaea,Ginkgo biloba,Medicago sativa,Lycium barbarum,Glycyrrhiza glabra,Polygonatum sibiricum,Dovyalis caffra,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Bacillus sp. in firmicutes,Scombridae gen. sp.)
• Cellular Signaling Pathways Modulated by Low-intensity Extracorporeal Shock Wave Therapy (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• BMPR signaling (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Gallus gallus,Macaca fascicularis,Turdus migratorius,Lama glama)
• Mechanistic interactions between VEGF-targeted anti-angiogenic therapy and checkpoint inhibitors in the systemic treatment of mRCC (2019, NA)
• Proposed mechanism for kCer acting as a Sema3A-like ligand (2019, NA)
• Crosstalk between mitochondria and peroxisome: the pathogenic Mtb enters into the macrophage cells via different PRRs like mannose receptor (MRs) or TLRs (2019, NA)
• WNTs signaling pathway regulated autophagy and EMT (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• Integrin signaling pathway regulated autophagy and EMT (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• P53 signaling pathway regulated autophagy and EMT (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• Beclin-1 signaling pathway regulated autophagy and EMT (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• Proposed oncogenic mechanisms for Plk1 (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Hepatitis B virus)
• IL-1, IL-36, IL-37, and IL-38 receptors and intracellular signaling (2019, NA)
• Cellular action of FSH and FSHR through the classical cyclic AMP/protein kinase A signalling pathway (2019, NA)
• Association between miRNAs of interest and their predicted targets in the insulin signaling pathway (A) and Type II diabetes mellitus pathway (B) (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori)
• Hypoxia signaling in human diseases and therapeutic targets (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Oryctolagus cuniculus,Mirabilis mosaic virus)
• Hypoxia and aging (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Caenorhabditis elegans)
• Cancer–immunity cycle (2019, NA)
• Linking morphogenesis with antifungal drug treatment and drug resistance in Candida (2019, NA)
• Schematic diagram to illustrate the activation of the nuclear factorKB (NFKB) pathway in the radiation-induced rescue effect (RIRE) (2019, Danio rerio,Dipturus trachyderma,Homo sapiens,Mus musculus)
• KEGG cell cycle pathway analysis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Moonlighting functions of the endothelial protein C receptor (EPCR) (2019, Bacillus subtilis,Enterococcus faecalis,Homo sapiens,Mus musculus,Bos taurus,gut metagenome)
• YAP/TAZ regulate prostate cancer stem cells (PCSCs) (2019, NA)
• mTOR signaling pathway regulated autophagy and EMT (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• Elicitation as a tool to improve the profiles of high‐value secondary metabolites and pharmacological properties of Hypericum perforatum (2019, NA)
• Diagram of knockdown of TFPI-anchored endothelial cells induced a more severe LPS-induced acute lung injury via NFKB signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Escherichia coli,Pseudomonas aeruginosa,Homo sapiens,Armoracia rusticana)
• Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells (2019, NA)
• Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells (2019, NA)
• The role of LRRK2 on PKA-NFKB pathway in microglia cells: implications for Parkinson’s disease (2019, NA)
• Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Morchella esculenta)
• Photic signaling pathways involving main kinases activities in the circadian clock (2019, NA)
• Regulating EMT by targeting autophagy (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pleistophora sp. 1,Homo sapiens,Nostoc commune,Cyathopoma iota)
• Transcriptional changes of genes involved in fatty acid catabolism, MVA formation, and energy metabolism by ΔYPL062W, whose reactions mainly occur in the peroxisome (A), cytoplasm (B), and mitochondrion (C), respectively (2019, Saccharomyces cerevisiae,Homo sapiens)
• Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells (2019, NA)
• Summary and schematic diagram of this study (2019, NA)
• Proposed signaling pathway for LPI in cardiomyocytes that contributes to exacerbation of I/R injury (2019, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Armoracia rusticana,Glycine max,Homo sapiens)
• Model depicting drought tolerance of two sesame genotypes (2019, NA)
• Schematic model of IL‐1B‐ and Fn‐fs‐mediated ADAMTS‐12 and ‐7 stimulation by Runx2 and Wnt/B‐catenin signalling modulation in OA‐SF (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Punica granatum)
• SUMOylation‐mediated signalling pathway of cardiac hypertrophy (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Protection effects of Aucubin (AU) against lipid accumulation and inflammation in tyloxapol induced hyperlipidaemia mice and apoC‐III induced differential 3T3‐L1 cells via activating Nrf2/hemeoxygenase‐1 (HO‐1) signalling pathway (2019, NA)
• Roles of Slit/Robo in neurocyte navigation (2019, NA)
• Upstream regulatory molecules of Slit/Robo (2019, NA)
• Downstream targets of Slit/Robo (2019, NA)
• Slit/Robo protein proteolytic processing (2019, NA)
• PI3K/AKT and cell cycle signaling pathway model of NKTCL (2019, NA)
• mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGFB1––induced collagen biosynthesis (2019, NA)
• Pathway map for “LRRK2 in neurons in Parkinson’s disease” (2019, NA)
• Proposed regulation of the Cbr/Crc system in a P (2019, Pseudomonas donghuensis,Caenorhabditis elegans,Homo sapiens)
• Possibly mechanisms underlying dihydromyricetin (DMY) against sodium nitroprusside (SNP) in the HUVECs (2019, NA)
• Schematic diagram showing the two major insulin signaling pathways and the role of Mg2+ in metabolic signaling (2019, NA)
• Mechanistic cross-connection between the transforming growth factor beta pathway and bone morphogenetic protein signaling (2019, NA)
• Mechanism diagram (2019, NA)
• TRAIL death receptor pathway and its regulation by bioactive peptides (2019, Staphylococcus aureus,Arthrospira platensis,Homo sapiens,Mus musculus)
• STAT3 signaling pathway and its regulation by bioactive peptides (2019, Staphylococcus aureus,Arthrospira platensis,Homo sapiens,Mus musculus)
• Crosstalk between hepatocytes, hepatic nonparenchymal cells, and ncRNA during the pathology of NAFLD (2019, NA)
• Functioning of the AMPK signaling pathway in cell metabolism and its regulation by bioactive peptides (2019, Staphylococcus aureus,Arthrospira platensis,Homo sapiens,Mus musculus)
• PI3/AKT/mTOR signaling pathway in tumor cells and regulation by bioactive peptides of the PI3/AKT/mTOR signaling pathway (2019, Staphylococcus aureus,Arthrospira platensis,Homo sapiens,Mus musculus)
• Schematic represents regulatory molecules involved in the ubiquitin-lysosome, autophagy-lysosome and caspase-mediated degradation pathway of BCR-ABL protein (2019, Homo sapiens,Mus musculus)
• Schematic represents regulatory molecules involved in the ubiquitin-proteasome degradation pathway of BCR-ABL protein (2019, Homo sapiens,Mus musculus)
• Schematic shows the regulation of CCK-BR on IA and the involvement of CCK-8/CCK-BR in pain sensitivity (2019, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mustela putorius furo,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Adenoviridae)
• Schematic diagram illustrate the potential mechanisms of VPA and gemcitabine on pancreatic cancer cells (2019, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Scheme and working model (2019, Mus musculus,Rattus norvegicus,Bos taurus,Armoracia rusticana,Canis lupus familiaris,Vasconcellea candicans,Homo sapiens,unidentified,Bellapiscis medius)
• Non-canonical activation of HH-GLI signaling by oncogenic pathways (2019, NA)
• Canonical activation of HH-GLI signaling (2019, NA)
• HoxA10-mediated inhibition of HBV replication (2019, NA)
• Sub-network of the innate signaling pathway obtained after IPA analysis of the differentially expressed genes in A549 lung epithelial cells infected with WM 06.482 conidia (2019, NA)
• Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets (2019, NA)
• Shown are the edges whose scores exceeded the threshold ; edges are labelled with their scores (2019, Arabidopsis thaliana,Homo sapiens)
• Transcriptome sequencing of olfactory-related genes in olfactory transduction of large yellow croaker (Larimichthy crocea) in response to bile salts (2019, NA)
• Lysosome as the nutrient sensor and signaling hub of the cell (2019, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,adeno-associated virus 2)
• Simplified signaling pathway: this simplified signaling cartoon encompasses all significant molecular changes detected in this study in spleen, hippocampus, and plasma after PEA treatment (PEA/sal) (2019, NA)
• Network diagram displaying the IAV-dependent phosphorylation changes in the actin cytoskeleton and focal adhesion KEGG pathways (2019, NA)
• Salient features of EBV latent transcripts during B-cell transformation, followed by B-cell lymphoma development (2019, NA)
• Simplified schematic of the PI3K pathway, which highlights the common targets for small molecule inhibitors (2019, Homo sapiens)
• Proposed pathway for metabolic detoxication of AAI (2019, Zea mays,Diaporthe sclerotioides,Triticum aestivum,herbal medicine,Cucumis sativus,Melia azedarach,Avena sativa,Candida pruni nom. inval.,Rheum tanguticum,Aristolochia clematitis,Betula utilis subsp. albosinensis,Aristolochia fimbriata,Aristolochia manshuriensis,Asarum sieboldii,Aristolochia fangchi,Saruma henryi,Aristolochia tomentosa,Aristolochia macrophylla,Aristolochia debilis,Aristolochia mollissima,Aristolochia taliscana,Aristolochia contorta,Asarum canadense,Fusicladium mandshuricum,Asarum europaeum,Aristolochia grandiflora,Aristolochia fordiana,Aristolochia argentina,Aristolochia baetica,Aristolochia cucurbitifolia,Aristolochia cymbifera,Aristolochia gibertii,Aristolochia indica,Aristolochia kaempferi,Aristolochia kwangsiensis,Aristolochia maurorum,Aristolochia maxima,Aristolochia moupinensis,Aristolochia odoratissima,Aristolochia ovalifolia,Aristolochia ringens,Aristolochia triangularis,Aristolochia trilobata,Aristolochia westlandii,Aristolochia pothieri,Aristolochia californica,Aristolochia zollingeriana,Aristolochia bracteolata,Aristolochia serpentaria,Aristolochia chamissonis,Aristolochia littoralis,Aristolochia sempervirens,Aristolochia fontanesii,Aristolochia paucinervis,Aristolochia acuminata,Aristolochia rotunda,Aristolochia heterophylla,Asarum campaniflorum,Asarum sagittarioides,Asarum himalaicum,Mus musculus,Rattus norvegicus,Dipturus trachyderma,Molva molva,Homo sapiens,Canis lupus familiaris)
• Negative regulators of NRF2 are found in autophagy (2019, NA)
• Mechanistic diagram of NGF and ILM-mediated proliferation promotion by regulating cell cycle of Müller cells (2019, NA)
• unctions and subsequent pathways of eukaryotic initiation factor 5A2 in human digestive system neoplasms (2019, NA)
• Mechanism of rapamycin’s anti-angiogenic and anti-lymphangiogenic effects in melanoma (2019, NA)
• Alternative pathway of the complement system (2019, NA)
• Ketamine on the glutamatergic synapse (2019, NA)
• EA ameliorates osteoclastogenesis by inhibiting NFKB (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Bone development and skeletal homeostasis (2019, Homo sapiens,NA)
• Schematic graph of the proposed cardioprotective mechanism of H2 when rats were exposed to CIH (2019, NA)
• Human mTOR pathway (2019, NA)
• Wnt/Beta-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast (2019, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Equus asinus,bacterium 4B-7)
• Cellular response to small molecules that selectively stall protein synthesis by the ribosome (2019, Saccharomyces cerevisiae,Armoracia rusticana,Lareunionomyces loeiensis,Mus musculus,Rattus norvegicus,vectors,synthetic construct,Homo sapiens,Danio rerio,teschovirus A1)
• Integrative pathway enrichment analysis showing the interaction between predicted and experimental targets (2019, Saccharomyces cerevisiae,herbal medicine,Astragalus membranaceus,Homo sapiens,Rattus norvegicus,Hepatitis B virus,clinical samples)
• RANKL-RANK signaling pathway via Btk in osteoclast differentiationTec family kinases are activated by RANK and bind to scaffolding proteins (BLNK or SLP76) activated by ITAM signaling, thereby forming a complex that cooperates to activate PLCG2 (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Hippo pathway regulation of advanced prostate cancer (2019, NA)
• Possible mechanisms of action of targeted polyIC (2019, NA)
• Exposure of Candida albicans B (1,3)-glucan is promoted by activation of the Cek1 pathway (2019, Candida albicans,Homo sapiens)
• Application of built-in adjuvants for epitope-based vaccines (2019, NA)
• Theory for polymicrogyria and brain arteriovenous malformations in HHT (2019, Homo sapiens)
• Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• PTEN/PI3K/AKT/FOXO3 signaling and pathway modulators (2019, NA)
• Proposed molecular mechanism of EP that protects the kidney against renal IR injury (2019, NA)
• Bradykinin effect on TJs: bradykinin (BK), interacting with its receptors B1R and B2R, induces the intracellular release of Ca2+ that can affect occludin polymerization as well as increase the production of nitric oxide that relaxes the junctions (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Human immunodeficiency virus,unidentified,Clostridium perfringens,Filamentous phage)
• Enriched integrin signaling pathway in non-type subtype of bladder carcinoma cell lines (2019, Saccharomyces cerevisiae,Armoracia rusticana,Lareunionomyces loeiensis,Sequoia sempervirens,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Mycobacterium tuberculosis H37Rv)
• Ulmus macrocarpa Hance modulates lipid metabolism in hyperlipidemia via activation of AMPK pathway (2019, Ulmus macrocarpa,Homo sapiens)
• Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K (2019, Saccharomyces cerevisiae,Eucalyptus intertexta,Citrus aurantiifolia,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens)
• Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K (2019, Saccharomyces cerevisiae,Eucalyptus intertexta,Citrus aurantiifolia,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens)
• Hippo Signaling pathway with marked expression levels of deregulated genes (2019, Homo sapiens,Mus musculus,Caenorhabditis elegans,Helicobacter pylori)
• Immune evasion mechanisms associated with the PD-1/PD-L1 signaling pathway in the tumor microenvironment of lymphoma (2019, Homo sapiens,Human gammaherpesvirus 4)
• Transforming growth factorB (TGFB) signaling pathway with marked expression levels of deregulated genes (2019, Homo sapiens,Mus musculus,Caenorhabditis elegans,Helicobacter pylori)
• Signaling pathways modulated by EV miRNAs associated with T2DM (2019, Homo sapiens,Mus musculus,gut metagenome)
• Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MAGE A11 in patients with esophageal squamous cell carcinoma (ESCC) (2019, NA)
• Activation of AMPK/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I/R) injury in rats (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants (2019, NA)
• YAP regulation in early stages of prostate cancer (2019, NA)
• Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of MAGE A9 in patients with esophageal squamous cell carcinoma (ESCC) (2019, NA)
• Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression (2019, Homo sapiens,NA)
• Common alterations in fluorosis‐proliferation and differentiation (2019, NA)
• Common alterations in fluorosis‐homeostasis & autophagy (2019, NA)
• Possible mechanisms responsible for the effect of Nox on SAP-associated cardiac injury (2019, NA)
• Main cellular protein clearance mechanisms, the ubiquitin–proteasome system (UPS), and the autophagy pathway (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Triticum aestivum,Brassica napus,Carica papaya,Dianthus caryophyllus,Oxybasis rubra,Paris polyphylla var. minor,Mus musculus,Heterocephalus glaber,Homo sapiens)
• Model depicting the potential involvement of the Mek/ERK1/2-MAPK and the PI3K/Akt/mTOR signaling pathways at different stages of developmental myelination and during adulthood (2019, Homo sapiens,Mus musculus,Capra hircus,Helianthus annuus,Phenes raptor)
• ASD causal genes affecting BMP signaling and potential crosstalk with other signaling pathways (2019, NA)
• PAK4 signaling in health and disease: defining the PAK4–CREB axis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio)
• Possible interactions between ASD causal genes and RA signaling (2019, NA)
• T cell receptor signaling pathway and cytokine-cytokine receptor interaction affect the rehabilitation process after respiratory syncytial virus infection (2019, NA)
• Melanogenesis (2019, NA)
• Musashi2 (Msi2) gene is a major factor in normal hematopoietic and leukemia stem cells (2019, NA)
• Illustration of the FGF16 signalling pathway to regulate Leydig cell development (2019, NA)
• PAK4 signaling in health and disease: defining the PAK4–CREB axis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio)
• The signalling pathways and deletions investigated in the current study (2019, NA)
• Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining (2019, NA)
• Model of JS‐K‐induced anti‐tumour activity in gastric cancer (2019, Mus musculus,Rattus norvegicus,Armoracia rusticana,Vasconcellea candicans,Homo sapiens,Bos taurus,Spleen focus-forming virus)
• Transcriptional Regulation of Proteasome Subunit Genes (2019, NA)
• Suggested mechanism of rFlaA:Betv1-mediated mDC activation (2019, NA)
• Leptin signaling pathways (2019, NA)
• Necroptosis signaling pathwayNecroptosis can be caused by a variety of stimuli, including the ligands of the death receptor, TLRs, IFN receptors, and certain pathogens (2019, NA)
• Frequent genetic alterations in genes from angiogenesis pathway in UBC (2019, Bos taurus,Oryctolagus cuniculus,Suricata suricatta,Homo sapiens,Mus musculus,Danio rerio,Armoracia rusticana,clinical samples)
• Regulation of FABP4/aP2 secretion from adipocytes (2019, NA)
• Metabolic model of Desulfosporosinus sp (2019, Desulfosporosinus sp.,Homo sapiens)
• Functions of IL-1B signaling in cancer (2019, NA)
• Activating p38 MAPK intersection signaling pathway (2019, NA)
• Synthetic representation of the main mechanisms leading to BRAF and MEK inhibitors acquired resistance frequently present in melanoma and colorectal cancer in vivo and in vitro (2019, Homo sapiens,Mus musculus,Coturnix coturnix,Linuche aquila,NA)
• Proposed model of IFN and inflammasome activation by HCMV and IL-1B inhibition by IE86 (2019, NA)
• Regulatory mechanisms of the IL-17–TRAF6 pathway (2019, NA)
• Inflammatory loops in the EIME of psoriasis (2019, NA)
• Receptor signaling pathways upstream of TRAF6 (2019, NA)
• Synthesis, metabolic pathways and function of acetyl-CoA (2019, NA)
• Synthesis and function of NAD+ in the cytoplasm and nucleus (2019, NA)
• Construction of a regulatory network for integrated miRNA-target genes (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Osphranter robustus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Curcumin modulates cancer progression by controlling diverse signal transduction pathways (2019, NA)
• Anti-shock mechanisms of molecular hydrogen during sepsis (2019, NA)
• Mapping of hits in the MAPK signaling pathway (2019, Influenza A virus,unidentified influenza virus,Vesicular stomatitis virus,Ebola virus,Lyssavirus rabies,Foot-and-mouth disease virus,Human orthopneumovirus,SARS coronavirus NS-1,Human respirovirus 3,Bovine orthopneumovirus,Aichivirus A,Saccharomyces cerevisiae,Bos taurus,Canis lupus familiaris,Prunus armeniaca,Homo sapiens,Mus musculus,NA,NA)
• Polyphenols modulating upstream (TLR activation) and downstream (different kinase and transcription factors) pathway of surface and endogenous TLR to reduce or demolish pro-inflammatory cytokines and type I interferon generation (2019, NA)
• Anti-apoptosis mechanisms of molecular hydrogen in sepsis (2019, NA)
• Anti-inflammation mechanisms of molecular hydrogen during sepsis (2019, NA)
• Known mechanisms and signaling pathways involved in histone deacetylase inhibitor-activated induction or suppression of autophagy (2019, Homo sapiens)
• Iron handling in the tumor microenvironment (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Xanthorhoe munitata,Mycobacterium tuberculosis SP1)
• SOCS induction by and inhibition of the JAK/STAT pathway (2019, Human betaherpesvirus 5,Murid betaherpesvirus 1,Mus musculus,NA,Homo sapiens)
• Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation (2019, gut metagenome,metagenome,Homo sapiens,Mus musculus,Candida dubliniensis)
• Insulin resistance mechanism and potential sites of vanadium activity (2019, Homo sapiens)
• Tumor-associated macrophage (TAM) function in the ovarian cancer tumor microenvironment (TME) and examples of therapeutic strategies (2019, Homo sapiens,Mus musculus,Human papillomavirus,NA)
• TLRs-signaling in microglial cells in different neurodegenerative disease progression (2019, NA)
• Gene net correlated to JA, ABA and other hormone biosynthetic, signaling and response pathway under water stress (2019, Oryza sativa,Arabidopsis thaliana,Nicotiana tabacum,Zea mays,Glycine max,Solanum lycopersicum,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Malus domestica,Cucumis sativus,Sorghum bicolor,Brassica oleracea,Populus trichocarpa,Brassica juncea,Oryza sativa Indica Group,Panicum miliaceum,Larrea tridentata,Saccharum spontaneum,Brassica rapa Broccoletto Group,Erythrina lysistemon,Pseudomonas syringae,Pseudomonas syringae pv. japonica,Moloney murine leukemia virus,NA)
• Neuroprotective mechanisms of antidiabetic drugs in the context of Parkinson’s disease dementia (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Canis lupus familiaris)
• Adiponectin-induced signaling pathway (2019, NA)
• Leptin-induced signaling pathway (2019, NA)
• The interactions involved in the alteration of DC function following exposure to F (2019, Faecalibacterium prausnitzii,Homo sapiens)
• Simplified diagram of the signaling assays measured (2019, NA)
• Crosstalk of signaling pathways under butyrate influence (2019, NA)
• Effect of butyrate on methylation of oncogene HEY1 (2019, NA)
• Effect of butyrate on the Wnt signaling pathway Butyrate can increase Wnt1/2/3 expression, which bind to their receptor Fzd to activate Wnt signaling pathway (2019, NA)
• Butyrate on signaling molecules through its receptors (2019, NA)
• Butyrate on Cell Death Pathway (2019, NA)
• Cell surface and endosomal signaling pathway of TLRs (2019, NA)
• Networks of Ingenuity Canonical Pathways results of mRNA of APP/PS1 and SAMP8 mice brain tissues (2019, NA)
• Possible mechanisms releasing mitochondrial components into the circulation (2019, NA)
• Schematic illustrating the mechanism in which elevated HP induces apoptosis in RGCs through the regulation of the NGF signalling pathway (2019, NA)
• Set of motor neuron proteins in the MAPK signaling pathway (2019, Homo sapiens,Mus musculus)
• TREM2 activation and downstream signaling (2019, Homo sapiens,Mus musculus,prion)
• Scheme of the mechanisms involved in the rise of blood pressure in low calcium intake by an increase in peripheral vascular resistance (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cross-talks between tumor and immune cells determining chemo-immune-resistance (2019, NA)
• Pathway analysis reveals the dysregulated expression of apoptosis-inducing genes (2019, NA)
• Some of the signaling pathways involved in the differentiation of ADSCs into IPCs (2019, NA)
• TGF-Beta-mediated skeletal muscle fibrosis (2019, NA)
• This figure shows the insulin signaling pathway (2019, NA)
• Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Non-A non-B hepatitis virus)
• Fighting Thyroid Cancer with Microgravity Research (2019, Homo sapiens,Mus musculus,Betapolyomavirus macacae,Pyrocystis noctiluca)
• MDSC-dependent promotion of PMN formation and evolution (2019, Homo sapiens,Mus musculus)
• Cytokine-cytokine receptor interaction signaling pathway map in the male group (2019, Lareunionomyces loeiensis,Psidium guajava,Homo sapiens,Mus musculus)
• Hematopoietic cell lineage signaling pathway in the male and female groups (2019, Lareunionomyces loeiensis,Psidium guajava,Homo sapiens,Mus musculus)
• Small molecule inhibitors and the ALK-Smad signaling pathway (2019, NA)
• Molecular process of DNA damage repair associated with PARP inhibitor sensitivity and resistance (2019, NA)
• Complement pathway (2019, NA)
• The roles of the cAMP-PKA and cGMP-PKG pathway in DRG neuron hyperexcitability after peripheral injury or injury- related stress including chronic compression of DRG (CCD) and acute dissociation of DRG (ADD) (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Castor fiber,Homo sapiens,Drosophila melanogaster)
• Schematic overview of DNA demethylation during glioma progression (2019, NA)
• Schematic relationships between the wound-induced signal transduction mechanisms for the sesquiterpene biosynthesis and regulation in Aquilaria species for the agarwood production (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Solanum lycopersicum,Embryophyta,PX clade,Magnoliopsida,Artemisia annua,Cucumis melo,Aspergillus sp.,Fusarium solani,Penicillium sp.,Fusarium sp.,Chaetomium sp.,Aquilaria sinensis,Xylaria sp.,Imperata cylindrica,Lasiodiplodia sp.,Aquilaria crassna,Aquilaria malaccensis,Chamaemelum nobile,Aquilaria microcarpa,Gyrinops salicifolia,Bothriochloa ischaemum,Gyrinops walla,Pieris brassicae,Zeuzera conferta,Homo sapiens,Escherichia coli)
• Social status regulates the hepatic miRNAome in rainbow trout: Implications for posttranscriptional regulation of metabolic pathways (2019, Oncorhynchus mykiss,teleost fish,Dipnomorpha,Salmo trutta,salmonid fish,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,unidentified,artificial sequences)
• Schematic model depicting the proposed signaling pathway in LH/hCG-induced the resumption of meiosis (2019, NA)
• Effect of the PI3K/AKT signaling pathway on gynecological tumors (2019, NA)
• Mechanism of Action of FSH on Adipocytes (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• P53-HSF1-PGC1A integrated responses in HD (2019, NA)
• Proposed model of molecular interactions and clustering analysis (2019, NA)
• Upregulated genes in proteasome biosynthetic pathway at 24 h after inoculation using F (2019, NA)
• Different forms of programmed cell death and associated cascades (2019, NA)
• Diversity of the effects of DJ-1 in cell (2019, NA)
• Cytosolic recognition of foreign nucleic acids and activation of interferon stimulated genes (ISGs) (2019, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Zika virus,West Nile virus,Measles morbillivirus,Enterovirus A71,Encephalomyocarditis virus,Sindbis virus,Reovirus sp.,Lyssavirus rabies,Ebola virus sp.,Yellow fever virus,Dengue virus type 2,SARS coronavirus NS-1,dsRNA viruses,Zaire ebolavirus,Flock House virus,Drosophila C virus,Cricket paralysis virus,Invertebrate iridescent virus 6,Drosophila X virus,Nora virus,Gekko adenovirus,Nodamura virus,Culex Y virus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Cricetus cricetus,Aedes aegypti,Homo sapiens,Saccharomyces cerevisiae,Archaeoglobus fulgidus,NA,NA,NA,NA)
• The proposed mechanisms of IRF5 activation (2019, Staphylococcus aureus,Mycobacterium tuberculosis,Chlamydia trachomatis,Mycobacterium avium subsp. paratuberculosis,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Homo sapiens,Mus musculus,Candida albicans,NA)
• Pathway visualization using downregulated differentially-expressed unigenes in cAMP signaling, Focal adhesion, Calcium signaling, Hippo signaling in fly and Notch signaling (2019, Culicoides sonorensis,Homo sapiens)
• Pathway visualization using downregulated differentially-expressed unigenes in Axon guidance, Regulation of actin cytoskeleton and Adherens junction (2019, Culicoides sonorensis,Homo sapiens)
• DEGs that are located in the neighborhood (putative cis-targets) of DELs and that are associated with Notch signaling pathway and stress granule formation (2019, NA)
• Simplified reference TLR signaling pathway projected onto putative homologs in Trichoplax sp (2019, Trichoplax sp. H2,Cerobasis alpha,Crassostrea gigas,Branchiostoma lanceolatum,Pinna nobilis,Branchiostoma floridae,Bilateria,Mytilus galloprovincialis,Amphimedon queenslandica,Trichoplax adhaerens,Acropora digitifera,Homo sapiens,Candida dubliniensis,NA)
• Putative Celangulin V biosynthetic pathway in C (2019, Celastrus angulatus,Homo sapiens)
• Pathway visualization (2019, Homo sapiens,Mus musculus)
• Dual functions of the cancer cell-intrinsic Hippo pathway in immune modulation (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Mycobacterium tuberculosis)
• Roles of the Hippo pathway in effector T cell differentiation (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Mycobacterium tuberculosis)
• Canonical NFKB signaling pathway (2019, NA)
• Canonical and alternative Hippo pathways (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Mycobacterium tuberculosis)
• NOX4-related mechanisms in thyroid carcinogenesis (2019, NA)
• Alternative (backdoor) androgen production and masculinization in the human fetus (2019, NA)
• Proposed mechanism between mTOR Signaling Pathway, Inhibitors and Photodynamic Therapy (PDT) (2019, NA)
• mTOR Signaling pathway (2019, NA)
• Schematic view of PKCA inhibitory activity on the Wnt/Beta-catenin signaling pathway in the normal colon epithelium and in colon cancer (2019, Erythroxylum coca,Zea mays subsp. mays,Euphorbia peplus,Croton tiglium,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Cerobasis alpha,Bugula neritina,Homo sapiens,unidentified)
• RKIP protein as a signaling modulator in lung cancer (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,Nicotiana tabacum,unidentified)
• Illustration of the main signaling pathways activated upon Ang2 binding to endothelial cells (2019, Mus musculus,Rattus norvegicus,Staphylococcus aureus,Mouse mammary tumor virus,Human gammaherpesvirus 8,Mycoplasmopsis pulmonis,Homo sapiens,Oryctolagus cuniculus,NA)
• LOXL1 in NSCLC tumorigenicity (2019, NA)
• Role for fibroblast-derived metabolites in tumor-stroma interactions (2019, NA)
• TGFB Signaling (2019, Homo sapiens,Mus musculus)
• Signal crosstalk in NFKB transcriptional regulation (2019, NA)
• Mitochondria and ER in activation of the NLRP3 inflammasome (2019, NA)
• Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis (2019, NA)
• Kinases in the insulin signaling cascades and its interaction with nutrients in control of FOXO1-mediated physiological function (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Litchi chinensis,NA)
• Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis (2019, NA)
• PPAR (peroxisome proliferator-activated receptor) signaling pathway enriched of differentially expressed genes (DEGs) in the jejunum of broiler chickens (2019, Mus musculus,Rattus norvegicus,Escherichia coli,Gallus gallus,Diaporthe sclerotioides,Candida dubliniensis,Oncorhynchus mykiss,Infectious bronchitis virus,Escherichia coli 27A,Gallid alphaherpesvirus 2,Homo sapiens,Sus scrofa)
• Flaccidoxide-13-acetate-induced apoptotic pathway in bladder cancer cells (2019, Homo sapiens)
• The PI3K/AKT signaling pathway (2019, NA)
• Interconnected pathways of non-essential amino acids (NEAA) metabolism (2019, NA)
• Signaling Pathways and Cellular Processes Regulated by Keratins, Vimentin, and Nestin (2019, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human papillomavirus type 16)
• RAC1 signaling in tumor cells: RAC1 signaling in tumors cells and the involvement of the RAC1 protein in tumorigenesis and drug-resistance as presented in the review (2019, NA)
• Hedgehog signaling pathway (2019, NA)
• Main O2-sensing pathways described in plants (identified in Arabidopsis and hypothesized to be present in M (2019, NA)
• Sublytic C5b-9 promotes tumor growth and survival by activating several signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 4)
• Downstream effector proteins of the major Rho GTPases, Rac1, Cdc42, and RhoA (2019, NA)
• Effect of chronic treatment with PDF and addition of AlaGln on individual pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Mutations in key pathways controlling cell growth (2019, Homo sapiens,Bos taurus,Human gammaherpesvirus 4,Venustaconcha ellipsiformis,Cladophora subtilissima)
• Target sites of therapeutics along the pathogenetic pathway of celiac disease (2019, NA)
• YAP/TAZ-mediated regulatory networks in cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Schematic model of regulation of the Hippo pathway by numerous signaling pathways in cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• The Hippo pathway in the pathogenesis of tissue fibrosis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• De novo pyrimidine and purine synthesis pathways (2019, NA)
• Regulation of YAP/TAZ in epidermal cells (2019, NA)
• PyCyp protein effects on EGFR signaling in IEC-6 cells (2019, Arabidopsis thaliana,Armoracia rusticana,PX clade,Chlamydomonas reinhardtii,Neopyropia yezoensis,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• The consequences of tricarboxylic acid (TCA) cycle disruption in pheochromocytomas and paragangliomas (PPGL) (2019, Homo sapiens,Mus musculus)
• Stress signal path model of WRKY participation (2019, Zanthoxylum bungeanum,synthetic gene)
• Top left: Wnt binds to the Frizzled receptor (Fz) and the LRP5/6 co-receptor (2019, NA)
• Working model for the effects of DCA described in this study (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Schematic overview of pathways that are involved in desmoplasia in pancreatic cancer, including drugs and their targets (2019, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Olea europaea,Triportheus paranensis,Sturnus vulgaris,Homo sapiens)
• B1 integrin induces EGFR- or HER (ErbB2)-targeted therapy resistance (2019, NA)
• MiniSOX9 has an oncogenic behavior in CRC (2019, NA)
• Phosphodiesterases (PDEs) in the pituitary gland: After stimulation of somatotroph cells via GHRH, the G protein coupled receptor is activated, which causes a conformational change of the receptor (2019, NA)
• Differential expression and bioinformatics analysis of circRNA in osteosarcoma (2019, NA)
• Stem cell-related signaling pathways in miR-25 overexpressing LX-2 cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Danio rerio,Lareunionomyces loeiensis,Adeno-associated virus)
• Immunogenic Cell Death (ICD) and Tolerogenic Cell Death (TCD) (2019, NA)
• Dysfunctional subpathway (path:04020_1) of calcium signaling pathway in CESC (2019, Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Diaporthe sclerotioides,Human papillomavirus type 16)
• The pathogen‐derived molecules employed to evade the intracellular DNA sensing pathway (2019, Dengue virus,Zika virus,West Nile virus,Japanese encephalitis virus,Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,DNA viruses,Ebola virus,Measles morbillivirus,Murid betaherpesvirus 1,Foot-and-mouth disease virus,Yellow fever virus,Human orthopneumovirus,ssRNA viruses,SARS coronavirus NS-1,Human metapneumovirus,Modified Vaccinia Ankara virus,Human adenovirus sp.,Dengue virus group,Alphapapillomavirus 7,Virus-associated RNAs,New world arenaviruses,Toscana virus,Human papillomavirus 151,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pyogenes,Shigella flexneri,Streptococcus sp. group A,Streptococcus sp. group B,Vibrio vulnificus,prion,unidentified,Homo sapiens,Mus musculus,Plasmodium falciparum,NA,NA,NA,NA)
• Graphic abstract (2019, NA)
• 17Beta-Estradiol induced estrogen receptor-alpha, -beta, and G-protein-coupled estrogen receptor signaling (2019, NA)
• CREB-B acts as a key mediator of NPF/NO pathway involved in phase-related locomotor plasticity in locusts (2019, NA)
• Mechanism of anti-hOrai1 channel monoclonal antibody (mAb) action on the human T-cell (2019, NA)
• Integration of photosynthetic light reactions and C metabolism (2019, NA)
• Hydrogen sulfide interaction and effects upon the activity of its biological targets (2019, NA)
• Putative mechanisms involving ET-1 system whereby MPs released under VEGFi treatment causes endothelial cell dysfunction (2019, NA)
• Fistein Suppresses Human Osteosarcoma U-2 OS Cell Migration and Invasion via Affecting FAK, uPA and NF-ĸB Signaling Pathway In Vitro (2019, Homo sapiens)
• Model: The role of secCl within the tyramine/leucokinin diuretic pathway (2019, Drosophila melanogaster,Apis mellifera,Aedes aegypti,Bilateria,Chandlerella quiscali,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris,Xenopus laevis,Avian myeloblastosis virus)
• Schematic diagram illustrating insulin-induced PD-L1 up-regulation and EGF help in PD-L1 transport in colon CSCs (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human papillomavirus)
• Influence of non-oncogenic viruses on the components of non-canonical NFKB signaling (2019, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Human gammaherpesvirus 8,Vaccinia virus,Human T-cell leukemia virus type I,H5N1 subtype,Measles morbillivirus,Enterovirus A71,Human alphaherpesvirus 3,Sindbis virus,Lyssavirus rabies,Human orthopneumovirus,Orf virus,Ateline gammaherpesvirus 2,Bovine foamy virus,Bos taurus,Capra hircus,Ovis aries,Homo sapiens,Mus musculus,NA,NA)
• Hypothesized therapeutic role of blocking IL6 pathway in Sarcoidosis (2019, NA)
• Interaction between miRNAs and TGFB pathway in GC (2019, NA)
• Lymphatic vessel functions during tumor progression (2019, NA)
• UPR signaling cascade (2019, NA)
• Schematic model of DHAV-1 inhibiting type I interferon signaling by hijacking the SOCS3 protein (2019, NA)
• M6A function in AML (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Betapolyomavirus macacae)
• Graphical representation of organohalogen exposure to mitochondrial disease AOP (2019, NA)
• Schematic presentation of the anti-TNBC mechanism of Ilamycin C (2019, Streptomyces atratus,Streptomyces sp. SCSIO 11594,Homo sapiens,Penicillium brevicompactum)
• Gene network analysis of RNA-Seq data from MDA-MB-231 and OVCAR3 cells (2019, NA)
• Possible mechanisms underlying the reinforcing and analgesic effects of alcohol exposure (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Nicotiana tabacum,Chlorocebus aethiops,Cannabis sativa,Phytomonas oxycareni)
• Interaction between miRNAs and FSH pathway in GC (2019, NA)
• Health to disease (HTD) network (2019, NA)
• Insulin and autophagy signaling modulation in Huntington’s disease (HD) (2019, Homo sapiens,Macaca mulatta,Saimiri sciureus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Canis lupus familiaris,Zea mays,Akkermansia muciniphila)
• Summary of changes related to insulin-autophagy pathway observed in Parkinson’s Disease (2019, Homo sapiens,Macaca mulatta,Saimiri sciureus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Canis lupus familiaris,Zea mays,Akkermansia muciniphila)
• Treatment to health (HTD) network (2019, NA)
• PI3K-AKT-mTOR signaling and Metformin targets (2019, Homo sapiens,Macaca mulatta,Saimiri sciureus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Canis lupus familiaris,Zea mays,Akkermansia muciniphila)
• Interaction between miRNAs and apoptosis pathway in GC (2019, NA)
• Drosophila Hippo pathway Network (2019, NA)
• Diagram of major H4K20-related proteins and their proposed role in DNA double stranded break (DSB) repair (2019, NA)
• Mechanistic role of NRP-1 in intrahepatic angiogenesis of liver cirrhosis.A proposed model depicting the role of NRP-1 in intrahepatic angiogenesis of liver cirrhosis (2019, Homo sapiens,Mus musculus,Bos taurus,Olea europaea,Lactococcus phage P001)
• Mechanism of lncRNA MBNL1-AS1 involved in the biological activity of NSCLC CSCs via regulation of TGFBR2 (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• An integrated gene interaction network built for genes related to wing dimorphism (2019, Sogatella furcifera,Homo sapiens)
• GPL pathway constructed in this study (2019, Nicotiana tabacum,herbal medicine,Salvia miltiorrhiza,Astragalus membranaceus,Atractylodes macrocephala,Engelhardia roxburghiana,Betula platyphylla,Oldenlandia diffusa,Curcuma zedoaria,Corethrodendron multijugum,Pseudostellaria heterophylla,Homo sapiens,Rattus norvegicus,Helicobacter pylori)
• Predicted metabolic pathway of lignocellulose-derived inhibitors (2019, Amorphotheca resinae)
• Underlying mechanism of SSa on T cell-mediated immune surveillance in breast cancer (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana)
• Cell death pathways currently implicated in motor neuron cell death in ALS and related miRNAs (2019, NA)
• Mammalian Hippo pathway signaling (2019, Drosophila melanogaster,Homo sapiens)
• WWOX controls TGFB, Hyal-2, and Wnt signaling pathways that cross talks with the Hippo signaling (2019, Drosophila melanogaster,Homo sapiens)
• PD-1 signaling pathway in T cells.When engaged with a ligand, PD-1 becomes phosphorylated at its cytoplasmic tyrosine residue, leading to binding of protein tyrosine phosphatases (PTPs), such as SHP2 (2019, NA)
• TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress (2019, NA)
• Proposed MFG-E8 signaling in radial glial cells (RGL) via AvB3/PI3K/Akt/mTOR pathway (2019, Mus musculus,Rattus norvegicus,Sus scrofa,Mustela putorius furo,Homo sapiens,Gallus gallus,prion)
• Possible mechanism of CAPE-pNO2 inhibits TNBC growth and metastasis (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Exercise-induced myokines mediate organ cross-talk and improve cardiometabolic health (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Adeno-associated virus)
• Pathogenesis of hRSV and molecules with a biomarker potential induced in the airways during hRSV infection (2019, NA)
• Evaluations on Substrates of FBXL Family E3s(A and B) Known (red edge) and predicted (gray edge) ESIs for FBXLs (2019, NA)
• Comparison of a canonical, cAMP-signaling pathway in the human host cell and in Apicomplexan parasites: (A) Activation/reactivation cycle of a heterotrimeric G-protein in the context of G-protein-coupled receptor (GPCR) signaling: 1 (2019, Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Trypanosoma brucei,Leishmania major,Leishmania donovani,Plasmodium berghei,Plasmodium vivax,Cryptosporidium parvum,Leishmania mexicana,Glossina morsitans,Alveolata,Trypanosoma brucei rhodesiense,Leishmania tropica,Plasmodium sp. A,Euglenozoa,Cryptosporidium hominis,Cryptosporidium muris,Babesia motasi,Plasmodium reichenowi,Babesia caballi,Saccharomyces cerevisiae,Melia azedarach,Ardisia crenata,Mus musculus,Rattus norvegicus,Escherichia coli,Ovis aries,Equus caballus,Pasteurella multocida,Homo sapiens,Human immunodeficiency virus 1,NA)
• Schematic diagram shows the regulatory non-coding RNAs in NAFLD disease development and progression (2019, NA)
• Regulation of PD-L1 expression in response to DNA damage in cancer cells (2019, Mycobacterium tuberculosis,Mycolicibacterium obuense,Homo sapiens,Mus musculus,Dipturus trachyderma,Trametes versicolor)
• Repair pathways and signaling in response to DSB induction by IR (2019, Mycobacterium tuberculosis,Mycolicibacterium obuense,Homo sapiens,Mus musculus,Dipturus trachyderma,Trametes versicolor)
• 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Armoracia rusticana)
• Eicosanoid synthesis pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• L-Norvaline, a new therapeutic agent against Alzheimer’s disease (2019, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Eucalyptus intertexta,Homo sapiens)
• Chronic inflammation activates multiple signaling cascades (2019, NA)
• Significant pathways identified using Tied Diffusion through Interacting Events method, an approach that can extract the most likely set of interconnectors between two sets of nodes (2019, NA)
• Molecular pathogenesis of Epstein-Barr virus-positive NK/T-cell lymphoma (2019, NA)
• VPA inhibits monocyte to DC cell differentiation (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• ERM structure and function in immune cells (2019, NA)
• The regulatory mechanism of miRNAs in TLR signaling (2019, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,unidentified influenza virus,Simian immunodeficiency virus,Leishmania RNA virus 1,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Francisella tularensis,Francisella tularensis subsp. novicida,Cryptosporidium parvum,Schistosoma japonicum,Homo sapiens,Mus musculus,Gallus gallus,Candida dubliniensis,NA)
• Analysis of severe asthma differential expression gene signature in the context of STRING protein association network (2019, NA)
• Examples of representations for contextualizing disease associated genes (2019, NA)
• MC4R signaling pathway plays a vital role in regulating appetite and energy balance (2019, Homo sapiens,Mus musculus)
• Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of T cell receptor signaling pathway in asthma (2019, NA)
• Proposed mechanism for the inhibitory effects of ASP on the migration, invasion, and angiogenesis of HCC cells (2019, NA)
• VHL-HIF-BNIP3 signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Nek2B-mediated chemotheropy-resistant mechanism in TNBC (2019, NA)
• Diagram summarising a critical role of ZEB1-tPA axis regulated by EGFR–RAS–ERK pathway in the development of lung fibrosis (details provided in Discussion) (2019, NA)
• Strategies to overcome NK resistance in solid tumors (2019, Homo sapiens)
• MINA Workflow (2019, Homo sapiens)
• Complement activation pathways and examples of complement-targeting therapeutics for IgAN (2019, NA)
• TGFB signalling pathway with FOXN3 (2019, Neogale vison,Nyctereutes procyonoides,Vulpes lagopus,Lycalopex griseus,Drosophila melanogaster,Xenopus laevis,Paracentrotus lividus,Cyprinus carpio,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• An overview of proteins and pathways activated and targeted by PemKSa toxin in C (2019, Caenorhabditis elegans,Homo sapiens)
• Cancer pathway gene set targeted only by natural products for a cancer driver target (2019, NA)
• GSK-3 signalling in heart (2019, Homo sapiens)
• Illustration of DEGs encoding the key enzymes of the ricinoleic acid biosynthetic pathway (2019, Ricinus communis,Homo sapiens)
• A model for the regulation of T cell-mediated adaptive immune responses to apoptotic cells (2019, NA)
• Parallel Molecular Evolution in Pathways, Genes, and Sites in High-Elevation Hummingbirds Revealed by Comparative Transcriptomics (2019, NA)
• Network for abnormal sub-pathway (2019, NA)
• Proposed model of ChemoRx-induced effects on PAF-R-dependent gemcitabine-induced MVP release (2019, NA)
• Sub-pathways identified using the sub-pathway strategy (2019, Homo sapiens,Mus musculus,Helicobacter pylori)
• Proposed mechanisms of polycystins implication in CRC (2019, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) mutations in the cytoplasmic region of the cysteine-X-cysteine chemokine receptor CXCR4 result in gain-of-function (2019, NA)
• Anti-tumor mechanism of Lycosin-I (2019, NA)
• Focal adhesion pathway (A) and HIF-1 signaling pathway (B) altered in a CRC (2019, NA)
• Involvement of circRNAs in the ErbB signaling pathway (2019, Homo sapiens)
• Biological interaction networking of identified HCAECs phosphoproteins in KD (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Involvement of circRNAs in the Hippo signaling pathway (2019, Homo sapiens)
• 15d-PGJ2 regulates adipocyte differentiation and osteoblast differentiation via a PPARGamma-dependent pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Interaction between tumor microenvironment components, including stromal cells, and tumor cells leads to enhanced cell growth, proliferation, angiogenesis and invasion (2019, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Signaling pathways implicated in different categories of breast cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Rhythms of life: circadian disruption and brain disorders across the lifespan (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Cricetus cricetus,Papio hamadryas,Drosophila melanogaster,Cannabis sativa)
• ERK signaling pathway was hyperactivated in the patient's tumor tissue (2019, Homo sapiens,Bos taurus,mixed sample)
• Negative regulators of JAK-STAT signaling (2019, NA)
• ERK signaling pathway was hyperactivated in the patient’s tumor tissue (2019, Homo sapiens)
• Hypothetical signaling pathway related to heterogeneous cytoplasm-induced suppression of the multi-ovary gene (2019, NA)
• Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NFKB expression (2019, Triticum aestivum,herbal medicine,Curcuma wenyujin,Wurfbainia villosa,Dioscorea oppositifolia,Adenophora triphylla,Fritillaria thunbergii,Homo sapiens,Mus musculus,Bos taurus,Molva molva)
• Signaling pathways related to RUNX3 (2019, NA)
• Signaling pathways related to RUNX2 (2019, NA)
• Signaling pathways related to RUNX1 (2019, NA)
• Proposed model for an auto-regulatory feedback loop between the miR-17-92 cluster and the Wnt/Beta-catenin/LEF1 signaling pathway (2019, NA)
• Type I interferons in the cytotoxic TLR-TNF signaling network (2019, Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica,Clostridioides difficile,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Salmonella enterica subsp. enterica serovar Typhi,Yersinia pestis,Vibrio parahaemolyticus,Yersinia pseudotuberculosis,Ureaplasma urealyticum,Clostridioides difficile CD40,Human betaherpesvirus 5,Enterovirus A71,Cowpox virus,Coxsackievirus A16,enterovirus D68,Coxsackievirus A6,Mus musculus,Rattus norvegicus,Homo sapiens)
• Cytotoxic TLR-TNF signaling network (2019, Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica,Clostridioides difficile,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Salmonella enterica subsp. enterica serovar Typhi,Yersinia pestis,Vibrio parahaemolyticus,Yersinia pseudotuberculosis,Ureaplasma urealyticum,Clostridioides difficile CD40,Human betaherpesvirus 5,Enterovirus A71,Cowpox virus,Coxsackievirus A16,enterovirus D68,Coxsackievirus A6,Mus musculus,Rattus norvegicus,Homo sapiens)
• TNFR2 signaling (2019, Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica,Clostridioides difficile,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Salmonella enterica subsp. enterica serovar Typhi,Yersinia pestis,Vibrio parahaemolyticus,Yersinia pseudotuberculosis,Ureaplasma urealyticum,Clostridioides difficile CD40,Human betaherpesvirus 5,Enterovirus A71,Cowpox virus,Coxsackievirus A16,enterovirus D68,Coxsackievirus A6,Mus musculus,Rattus norvegicus,Homo sapiens)
• TNFR1 signaling (2019, Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica,Clostridioides difficile,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Salmonella enterica subsp. enterica serovar Typhi,Yersinia pestis,Vibrio parahaemolyticus,Yersinia pseudotuberculosis,Ureaplasma urealyticum,Clostridioides difficile CD40,Human betaherpesvirus 5,Enterovirus A71,Cowpox virus,Coxsackievirus A16,enterovirus D68,Coxsackievirus A6,Mus musculus,Rattus norvegicus,Homo sapiens)
• IL-6 production by blood leukocytes is altered in the RA-like PsoA patient in response to immune activators (2019, Bos taurus,Bison bonasus,Homo sapiens,Mus musculus,Dipturus trachyderma)
• Results of Pancancer Pathway Panel analysis (2019, NA)
• Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors (2019, Human immunodeficiency virus 1,Adeno-associated virus,adeno-associated virus 2,Canine parvovirus,Adeno-associated virus - 4,Homo sapiens,Macaca mulatta,Macaca fascicularis,Mus musculus,Rattus norvegicus,Molva molva)
• Interesting putative mechanisms are identified by iPathwayGuide (www.advaitabio.com) on the Glutamatergic synapse and the Chemokine signaling pathways (2019, NA)
• Cellular pathway of the effects of MET + PTX-induced growth inhibition and apoptosis of PCa cells (2019, Armoracia rusticana,Persea americana,Homo sapiens,Mus musculus,Bos taurus)
• TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Escherichia coli)
• Intracellular hyperglycemia results in increased production of mitochondrial ROS (2019, NA)
• GPR88 signaling pathway (2019, NA)
• MAPK and MST2/Hippo signaling, energy and glucose metabolism (2019, NA)
• Hypothetic functional model of UASR1 (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• CSC signaling pathways which are regulated by BRCA proteins (2019, NA)
• Signaling pathway based on the literatures we reviewed (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Pan troglodytes,Saccharomyces cerevisiae CAT-1)
• TGF-beta signalling in bovine mammary gland involution and a comparative assessment of MAC-T and BME-UV1 cells as in vitro models for its study (2019, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Zea mays,Staphylococcus aureus,Betapolyomavirus macacae)
• PLK-dependent latent TGFB activation and TGFB/Smad signaling pathways (2019, NA)
• Acute phase response network: The acute phase response was the most-significantly represented pathway common to all CAPN5-NIV stages (2019, NA)
• Neuroprotective effects of osteocalcin (OCN) in rats with Parkinson’s disease (PD) (2019, NA)
• Schematic drawing of the suggested intracellular signaling pathways of LIF and OSM receptors in osteoblasts mediating expression of osteoclastogenic factors, osteoclast formation and bone resorption (2019, NA)
• Impact of flight condition on expression of crystallins in the network of proteins associated with ophthalmic disease as defined by Ingenuity Pathway Analysis (IPA, https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis) (2019, NA)
• Involvement of LOAD risk factors at the BBB (2019, NA)
• Spatial regulation of non-amyloidogenic and amyloidogenic processing of APP (2019, NA)
• Atypical PKCs control actin cytoskeleton via Cofilin activation (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Triportheus paranensis,Cerobasis alpha)
• Illustration of the synergistic effect of SNX-2112 and TRAIL in HeLa cells (2019, Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus,Plasmodium falciparum)
• Cartoon model of METTL14-P2RX6-Ca2+ −p-ERK1/2-MMP9 axis signal on RCC cell migration and invasion (2019, NA)
• Cholinergic signaling via nAChRs and muscarinic acetylcholine receptors (mAChRs) regulates striatal function (2019, NA)
• Functional significance of several key genes from four KEGG pathways differentially expressed in female and male magpies (2019, NA)
• Proposed ternatin biosynthetic pathway (2019, Clitoria ternatea,Saccharomyces cerevisiae,Zea mays,Glycine max,Diaporthe sclerotioides,Candida albicans,Aspergillus fumigatus,Magnoliopsida,Helianthus annuus,Pisum sativum,Aspergillus niger,Medicago sativa,Cryptococcus neoformans,Phaseolus vulgaris,Aspergillus flavus,Fusarium oxysporum,Petunia x hybrida,Rhizoctonia solani,Colletotrichum gloeosporioides,Garcinia mangostana,Cyamopsis tetragonoloba,Candida parapsilosis,Citrus aurantiifolia,Fusarium solani,Picea sitchensis,Vigna mungo,Alternaria sp.,Bipolaris oryzae,Syzygium cumini,Colletotrichum lindemuthianum,Momordica cochinchinensis,Cladosporium sp.,Lablab purpureus,Naganishia albida,Pterocarpus marsupium,Curvularia sp.,Leucaena leucocephala,Centrosema molle,Macadamia integrifolia,Papiliotrema laurentii,Rhizopus sp.,Viola tricolor,Trichosanthes dioica,Crossostylis biflora,Calopogonium mucunoides,Callitriche heterophylla,Ardisia paniculata,Setaria sphacelata,Afrohybanthus enneaspermus,Entada phaseoloides,Oldenlandia affinis,Canavalia brasiliensis,Vigna trilobata,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Bacillus subtilis,Klebsiella pneumoniae,Enterococcus faecalis,Bacillus subtilis At2,Streptococcus pyogenes,Bacillus cereus,Micrococcus luteus,Bradyrhizobium japonicum,Agrobacterium rhizogenes,Rhizobium sp.,Xanthomonas axonopodis,Streptococcus viridans,Bradyrhizobium elkanii,Pseudomonas aeruginosa PA1,Caenorhabditis elegans,Helicoverpa armigera,Meloidogyne javanica,Meloidogyne incognita,Eisenia fetida,Acanthoscelides obtectus,Metaphire posthuma,Zabrotes subfasciatus,Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Capra hircus,Cavia porcellus,Homo sapiens,Opsanus beta,NA)
• VGF/BDNF/TrkB autoregulatory feedback loop stimulates synaptic plasticity changes in response to rapid-acting antidepressant treatment (2019, Homo sapiens,Mus musculus)
• Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses (2019, NA)
• Rationale for choosing Arl13b, SMO, and melanin-concentrating hormone receptor 1 (MCHR1) as cilia-targeting moieties (2019, NA)
• Regulatory mechanism of LA1 on the activation of TLR4 pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Trametes sanguinea,Homo sapiens)
• Molecular factors involved in cell migration (2019, NA)
• Receptor signaling pathway and recruitment of IL-1RAcP (2019, NA)
• Summary of the proposed inhibitory mechanisms exhibited by WG-391D in ovarian cancer (2019, NA)
• A potential nuclear factorKB activation pathway obtained by RNA-sequencing analysis in canine diffuse large B-cell lymphomas (2019, Homo sapiens,Canis lupus familiaris)
• Model hypothesizing the potential regulation of Beta-catenin by G-alpha subunits and PMT (2019, NA)
• VPA induces apoptosis in neutrophils and diminishes their phagocytic capacity (2019, Staphylococcus aureus,Homo sapiens)
• Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses (2019, NA)
• Possible therapeutic implications of resveratrol/metformin/exercise in cognition through osteocalcin signalling (2019, NA)
• Overview of PI3K/AKT/mTOR signaling pathway (2019, NA)
• Targeting PI3K/Akt/mTOR pathway in cancer (2019, NA)
• Schematic diagram shows the mechanism underlying cTFRC as a ceRNA for miR-107 (2019, NA)
• Complement pathways (2019, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Acute methamphetamine (Meth) effects on altering astrocyte activity are mediated by TAAR1-coupled signaling and K+ channel dysfunction (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Human immunodeficiency virus 1)
• Complement regulators (2019, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Mechanism of salidroside-induced apoptosis, cell cycle arrest and suppressed invasion of osteosarcoma cells via inhibition of the JAK2/STAT3 signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Rhodiola rosea,Homo sapiens,Mus musculus)
• Graphic conclusion (2019, Bos taurus,Canis lupus familiaris,Homo sapiens,Mus musculus)
• Fatty acid synthesis (FAS) pathway in S (2019, Saccharomyces cerevisiae,Homo sapiens)
• miR-15/107 family targeted genes in cell cycle KEGG pathway calculated by miRPath v3.0 web-server (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• IL-17 inhibited fungal keratitis by reducing the level of CX43 through the AKT signaling pathway (2019, Mus musculus,Candida albicans,Homo sapiens)
• Illustration summarizes the molecular mechanism and signaling pathways underlying the effect of Dis on HCT-116 cells (2019, NA)
• Cause-effect relationship between oxidative stress and type 2 diabetes mellitus (T2DM) (2019, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Homo sapiens)
• VPA reduces the cytolytic activity in NK lymphocytes against tumor cells (2019, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Moraxella bovis,Mycobacterium tuberculosis SP1,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Japanese encephalitis virus,Coxsackievirus B3,Coxsackievirus,Mus musculus,Rattus norvegicus,Cannabis sativa,Valeriana officinalis,Homo sapiens,Xenopus laevis)
• Mechano-chemical transduction signaling pathways participating in the production of IL-6 (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Complement cascade and complement regulatory proteins (CRP) (2019, NA)
• LncRNA/pseudogene–miRNA–mRNA ceRNA network in CRC (2019, NA)
• Sonic hedgehog signaling controls dentate gyrus patterning and adult neurogenesis in the hippocampus (2019, Homo sapiens,Mus musculus)
• Multiple pathway stimulation of ADAM activity, leading to sAPPA proliferation and notch stimulation (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Vitamin D metabolism and signaling (2019, NA)
• Relationship between USP6NL and the pathway (2019, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Canonical and non-canonical NFKB pathway (2019, Klebsiella pneumoniae,Fasciola hepatica,Homo sapiens)
• Interaction of tumor-associated macrophages and cancer chemotherapy (2019, NA)
• Proposed regulatory mechanism of the Fbw7-XBP1s axis pathway (2019, Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Parturition-specific signaling networks constructed using shortest paths and differential expression data (2019, NA)
• IRFs in the TLR and IFN pathways (2019, NA)
• Tumor immunity by radiotherapy and immune checkpoint blockade (2019, NA)
• Signaling pathway analysis for Amphetamine, a stimulant with addiction (2019, NA)
• Signaling pathway analysis for Theophylline, an antagonist of adenosine A2a receptor for drug abuse (2019, NA)
• Scheme of role of 67-kDa LR in vasogenic edema formation induced by SE based on the present data and previous reports (, ; ; ) (2019, NA)
• Genetic Predisposition for Immune System, Hormone, and Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (2019, Homo sapiens,Mus musculus)
• Proposed molecular Wnt signaling pathway in lung fibrosis during ARDS (2019, Homo sapiens)
• UPR Signaling During Influenza A Virus Infection.Upon IAV infection, BiP is released from UPR proteins (e.g (2019, NA)
• Compound K, a ginsenoside metabolite, plays an antiinflammatory role in macrophages by targeting the AKT1-mediated signaling pathway (2019, NA)
• Schematic diagram showing the apoptosis effects of MB8 in HepG2 cell (2019, NA)
• Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease (2019, NA)
• Hypothetical mechanisms of the intracellular pathways underlying the results found in this study (2019, Rattus norvegicus,Homo sapiens)
• Proposed mechanisms of obesity-induced BAT depletion (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Capsicum frutescens)
• Complement activation cascades and functions (2019, NA)
• Signaling pathway of different DCs receptors (CLRs) (2019, NA)
• GPCR/EGFR-CARMA3 signaling pathway leading to NFKB activation (2019, NA)
• Apoptosis Signaling During Influenza A Virus Infection.IAV infection affects apoptosis in early and late infection (2019, NA)
• Regulation of complement activation by RCAs or parasite-expressed proteins targeting different complement components at the different steps of complement activation (2019, NA)
• Apoptosis Signaling During Arbovirus Infection.Arboviruses exert their effect on apoptosis through different signaling routes (2019, NA)
• Pathomechanisms and clinical features of diabetic cardiomyopathy (2019, NA)
• Mechanistically distinct regulation of VEGF secretion in MDA-MB-231 TNBC and T47D (ER+/PR+/HER2-) cells (2019, Homo sapiens,Mus musculus,Bos taurus)
• Current and future medical options for tumor control in neuroendocrine tumors (2019, Dipturus trachyderma,Triportheus paranensis,Homo sapiens)
• Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Biological parts utilised for combinatorial construction of a lycopene biosynthetic pathway (2019, NA)
• An illustrated view of Netrin-UNC5B signaling (2019, NA)
• Temporal dependence of G2/M DNA replication checkpoint mechanism on the G1/S transition mechanism (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Diaporthe sclerotioides,Schizosaccharomyces pombe,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway (2019, NA)
• Estrogen receptor (ER) activity in breast cancer - canonical (classical; ligand-mediated) and non-canonical (alternative; ligand-independent) pathways of ER activation (2019, NA)
• Anti-inflammatory and antioxidant mechanisms of neuroprotection and neuronal function by ursolic acid (2019, Candida dubliniensis,Malus domestica,Pyrus communis,Ipomoea batatas,Citrus limon,Salvia rosmarinus,Ocimum basilicum,Melissa officinalis,Origanum majorana,Artemisia indica,Stylosanthes hamata,Agastache mexicana,Primula vulgaris subsp. sibthorpii,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Sus scrofa,Proteus vulgaris)
• Deregulated Wnt signaling pathways in the BM of ENU induced experimental leukemic mice (2019, NA)
• Comparison of nucleic acid signalling pathways leading to type I interferon (IFN) production in an autoimmune disease and bacterial infection (2019, NA)
• Differential expression of A (2019, Acropora millepora,Homo sapiens)
• Human mesenchymal stem cells promote tumor growth via MAPK pathway and metastasis by epithelial mesenchymal transition and integrin A5 in hepatocellular carcinoma (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Proteome changes in (A) G-protein signaling pathway, (B) calcium signaling pathway and (C) ginsenoside synthesis pathway and (D) ribosomes biogenesis, ubiquitin-mediated proteolysis and RNA transport pathway (2019, NA)
• Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs (2019, NA)
• Modified KEGG map of the JNK and p38 MAP kinase signaling pathway showing transcriptional changes (2019, NA)
• Relationship between middle-age obesity, glutamate excitotoxicity and increased risk of Alzheimer’s disease (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Network view of infected dendritic cells (2019, Aspergillus fumigatus,Homo sapiens)
• Effects of DUSP5 deletion on oncogenic signalling through the Ras-ERK pathway may depend on the nature of the driving oncogene (2019, NA)
• Model illustrating the potential pathway from pseudohypoxia-induced cilia loss to increased cell proliferation and dysregulation of tumorigenesis relevant cilia-mediated signaling pathways in PCCs (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• The mechanism on apoptosis inducing effected of HA-based PDT (2019, NA)
• The deregulated metabolic pathways in AML (2019, NA)
• Anti-metastasis effect of inotilone and the proposed signaling pathway (2019, NA)
• Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway (2019, NA)
• Evolution of erlotinib resistance in CD166+ OSCs (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Moloney murine leukemia virus)
• Hippo signaling pathway which was achieved by DAVID pathway analysis (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Triticum aestivum,Oryza glaberrima,Acer tataricum subsp. ginnala,Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus,mixed sample)
• Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Staphylococcus aureus 7-B-1)
• Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Staphylococcus aureus 7-B-1)
• PI3K-AKT signaling pathway which was achieved by DAVID pathway analysis (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Triticum aestivum,Oryza glaberrima,Acer tataricum subsp. ginnala,Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus,mixed sample)
• The insulin signaling pathway and the modulation of this pathway by cannabinoid receptor type 1 (CB1R) (2019, NA)
• MTOR/S6K intracellular signal transduction pathways in the osteoclast (2019, NA)
• Cmah deficiency may lead to age-related hearing loss by influencing miRNA-PPAR mediated signaling pathway (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Staphylococcus aureus 7-B-1)
• ZINC24469384 regulates genes involved in P53 and STAT signaling pathways (2019, NA)
• T-cell receptor (TCR) binding to antigen-loaded MHC-II triggers T-cell initial activation (2019, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Rattus norvegicus,Antarctothoa delta)
• Downstream products of ROS promote endothelial cells (ECs) dysfunction in atherosclerosis (2019, NA)
• Interplay of major zonation signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Nicotiana tabacum,gut metagenome,Hepatitis B virus,NA)
• T-cell suppression and immune checkpoint blockage in tumor and organ rejection (2019, Homo sapiens,unidentified)
• Four hyperglycemia-induced pathogenic pathways which are related to overproduction of ROS and inflammation progression in atherosclerosis (2019, NA)
• Activation of the prolactin signalling pathway in the mink uterus in activated versus diapause states (2019, Bos taurus,Capra hircus,Sus scrofa,Mustela putorius furo,Mustela lutreola,Notamacropus eugenii,Neogale vison,Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus)
• NO signaling mediating NMDA-R activation in the central nucleus of the IC (2019, NA)
• Roles of PARPs in the immune response after pathogen invasion (2019, Homo sapiens)
• Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 signaling cascades (2019, NA)
• Activation of the PI3K/AKT signalling pathway in mink uteri in activated versus diapause states (2019, Bos taurus,Capra hircus,Sus scrofa,Mustela putorius furo,Mustela lutreola,Notamacropus eugenii,Neogale vison,Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus)
• RNA granules and caprin-1-associated tumorigenesis (2019, NA)
• Cofilin regulating the actin cytoskeleton and initiating PHEV entry (2019, Human immunodeficiency virus 1,Hepatitis B virus,Coronaviridae,Human alphaherpesvirus 1,H1N1 subtype,Human gammaherpesvirus 8,Ebola virus,Enterovirus C,Measles morbillivirus,Porcine reproductive and respiratory syndrome virus,Murine leukemia virus,Transmissible gastroenteritis virus,Infectious bursal disease virus,Porcine hemagglutinating encephalomyelitis virus,Homo sapiens,Mus musculus,Sus scrofa,Escherichia coli BL21,NA)
• BRO priming of NFkB target gene expression in the absence of virus (2019, NA)
• BRO priming of interferon response pathway in the absence of virus (2019, NA)
• BRO modulation of RV-induced NFkB target gene expression (2019, NA)
• KEGG-defined p53 signaling pathway with dysregulated mRNA and miRNA highlighted (2019, NA)
• Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices (2019, NA)
• Scheme of the effect of pioglitazone on CKD-mediated ER stress in CKD-MSCs (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Cricetus cricetus,Homo sapiens,Armoracia rusticana,prion)
• Gene-Pathway network (2019, Human papillomavirus,Dengue virus,Human papillomavirus type 16,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,Danio rerio)
• Intensity of information flow through the mTORC1-signaling pathway defines the fate of quiescent adult stem cells (2019, Homo sapiens)
• Some common metabolic features of adult stem cells are essential for the maintenance of their quiescence, number, proliferation potential, and differentiation ability (2019, Homo sapiens)
• Carbohydrate and protein metabolisms (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Representative summary of the non-glycolytic roles of GAPDH (2019, NA)
• EGF and TPA mediated pathway to phosphorylate serines in the SCFBTRCP recognition site of PDCD4-protein in Huh7 hepatoma cells (2019, Gallus gallus,Xenopus laevis,Dipnomorpha,Callorhinchus milii,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Acanthella cavernosa,Homo sapiens,Saccharomyces cerevisiae)
• Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway (2019, Armoracia rusticana,Vasconcellea candicans,Hypericum perforatum,Ecklonia cava,Citrus sunki,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,NA)
• Pathways of EGF mediated protein synthesis and PDCD4 degradation (2019, Gallus gallus,Xenopus laevis,Dipnomorpha,Callorhinchus milii,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Acanthella cavernosa,Homo sapiens,Saccharomyces cerevisiae)
• Signaling pathways interconnecting V-ATPase and glycolysis (2019, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Influenza A virus)
• V-ATPase integrates glycolytic signals to control cellular metabolism (2019, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Influenza A virus)
• VEGF in MRP1 expression (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Curcuma longa)
• Roles of c-Myc in colorectal cancer (CRC) organoids (2019, NA)
• Mechanisms of protection against enteroinvasive bacteria (Salmonella and Shigella) (2019, Escherichia coli,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Vibrio cholerae,Clostridioides difficile,Bacillus anthracis,Shigella flexneri,Campylobacter jejuni,Citrobacter rodentium,Faecalibacterium prausnitzii,Akkermansia muciniphila,Yersinia enterocolitica,Eubacterium rectale,Blautia coccoides,Clostridioides difficile CD40,Clostridioides difficile CD86,Salmonella enterica subsp. enterica serovar Typhimurium str. DT104,Helicobacter suis,Saccharomyces cerevisiae,Candida albicans,Litchi chinensis,Garcinia mangostana,Saccharomyces boulardii nom. inval.,Mus musculus,Rattus norvegicus,Entamoeba histolytica,Giardia intestinalis,Homo sapiens,Sus scrofa)
• Regulation of Wnt/Beta-catenin/c-Myc signaling pathway (2019, NA)
• IL-37 signaling pathway induced by TLR2/4 extracellularly and intracellularly (2019, NA)
• Mechanism of Nrf2 activation and Nrf2-mediated antioxidant responses in the lungs (2019, NA)
• Flavonoids on impaired insulin signaling (2019, Glycine max,Olea europaea,Spinacia oleracea,Allium cepa,Theobroma cacao,Vaccinium myrtillus,Euonymus alatus,Aristotelia chilensis,Tetracera scandens,Mus musculus,Rattus norvegicus,Phodopus sungorus,Homo sapiens,Opsanus beta)
• Normal insulin signaling (2019, Glycine max,Olea europaea,Spinacia oleracea,Allium cepa,Theobroma cacao,Vaccinium myrtillus,Euonymus alatus,Aristotelia chilensis,Tetracera scandens,Mus musculus,Rattus norvegicus,Phodopus sungorus,Homo sapiens,Opsanus beta)
• Suppositional pathway of AT together with PS-induced apoptosis in HepG2 cells (2019, NA)
• Interaction between TNFA and the Hippo signalling pathway (2019, NA)
• Hypothetical mechanisms by which the esophageal microbiota participates in the pathogenesis of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) (2019, NA)
• MVA pathway (2019, NA)
• Summarized molecular pathway of BDNF/TrkB's oncogenic role (2019, NA)
• NOD1 and TLR4 signaling pathways and the main target of CBN in the suppression of LPS-induced inflammation (2019, Angelica pubescens,Sparassis crispa,Angelica decursiva,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,gut metagenome,Molva molva,Escherichia coli O55,NA)
• Schematic model depicting RARA’s involvement in regulation of intracellular signaling, protein synthesis, and synaptic plasticity in postsynaptic neurons (2019, NA)
• Simplified schematic depiction of the major signalling cascades in filamentous fungal cell factories (2019, NA)
• Intracellular sensing of viral genomes and viral evasion (2019, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Severe acute respiratory syndrome-related coronavirus,Dengue virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,Orthomyxoviridae,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Zika virus,West Nile virus,DNA viruses,Ebola virus,Enterovirus C,Measles morbillivirus,Japanese encephalitis virus,Coxsackievirus B3,Murid betaherpesvirus 1,Enterovirus A71,Encephalomyocarditis virus,Coxsackievirus,Enterovirus,Murine hepatitis virus,Lyssavirus rabies,Foot-and-mouth disease virus,Human immunodeficiency virus 2,Human orthopneumovirus,Rift Valley fever virus,Murid gammaherpesvirus 4,Classical swine fever virus,Murid herpesvirus 68,Influenza B virus,Coxsackievirus A16,enterovirus D68,Echovirus,Porcine deltacoronavirus,Poliovirus 2,Severe fever with thrombocytopenia syndrome virus,Coxsackievirus A6,Murine norovirus 1,Coxsackievirus B2,Menangle virus,Salem virus,Saffold virus,Homo sapiens,Mus musculus,Listeria monocytogenes,NA,NA,NA,NA,NA,NA,NA,NA,NA)
• Intracellular sensing of viral genomes and viral evasion (2019, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Severe acute respiratory syndrome-related coronavirus,Dengue virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,Orthomyxoviridae,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Zika virus,West Nile virus,DNA viruses,Ebola virus,Enterovirus C,Measles morbillivirus,Japanese encephalitis virus,Coxsackievirus B3,Murid betaherpesvirus 1,Enterovirus A71,Encephalomyocarditis virus,Coxsackievirus,Enterovirus,Murine hepatitis virus,Lyssavirus rabies,Foot-and-mouth disease virus,Human immunodeficiency virus 2,Human orthopneumovirus,Rift Valley fever virus,Murid gammaherpesvirus 4,Classical swine fever virus,Murid herpesvirus 68,Influenza B virus,Coxsackievirus A16,enterovirus D68,Echovirus,Porcine deltacoronavirus,Poliovirus 2,Severe fever with thrombocytopenia syndrome virus,Coxsackievirus A6,Murine norovirus 1,Coxsackievirus B2,Menangle virus,Salem virus,Saffold virus,Homo sapiens,Mus musculus,Listeria monocytogenes,NA,NA,NA,NA,NA,NA,NA,NA,NA)
• ER stress and chemo-resistance: Role of inositol-requiring enzyme 1 alpha (IRE1), activating transcription factor 6 alpha (ATF6), and glucose-regulated protein 78 (GRP78) (2019, NA)
• Angiomotin-p130 inhibits Beta-catenin stability by competing with Axin for binding to tankyrase in breast cancer (2019, NA)
• CXCL5 induces tumor angiogenesis via enhancing the expression of FOXD1 mediated by the AKT/NFKB pathway in colorectal cancer (2019, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Rubus occidentalis)
• Networks representing protein-protein interactions in differentially regulated proteins from the NOD1 (HS578T/NOD1) (a) and NOD2 (HS578T/NOD2) (b) experimental groups (2019, Mus musculus,Rattus norvegicus,Helicobacter pylori,Porphyromonas gingivalis,Homo sapiens)
• LRF/ZBTB7A’s silencing compromises Warburg effect and induces apoptosis in cancer cells (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Yin-Yang model of hair follicle regeneration tuned by Wnt/BMP signaling (2019, NA)
• Small molecules guiding mesenchymal stem cell osteogenic cell fate determination (2019, Oryza sativa,Glycine max,herbal medicine,Vitis vinifera,Medicago truncatula,Salvia miltiorrhiza,Ginkgo biloba,Cicer arietinum,Scutellaria baicalensis,Sesamum indicum,Paeonia lactiflora,Ligustrum vulgare,Hippophae rhamnoides,Cordyceps militaris,Cullen corylifolium,Butea monosperma,Anethum graveolens,Tithonia diversifolia,Ajuga decumbens,Artemisia apiacea,Aiphanes horrida,Cornus walteri,Solanum muricatum,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Lacanobia radix,Homo sapiens)
• Biomechanical stress stimulates the mechanosensitive molecules on the EPC surface, and then induces cytoskeleton rearrangement and activates series of downstream signaling pathway (2019, NA)
• TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKB/VPS34 pathway (2019, Homo sapiens,Mus musculus,vectors)
• TGF and RBM5 signaling cascade (2019, NA)
• Homologous recombination (HR) repair deficiency represents an opportunity for a synthetic lethality approach through the use of PARP inhibitors (PARPi) (2019, Homo sapiens)
• Suppression of WNT2 in signaling pathway (2019, NA)
• Mechanism of simvastatin in alleviating endothelial dysfunction under oxidative stress (2019, Homo sapiens,Mus musculus,Bos taurus,Candida dubliniensis,Vaccinia virus)
• miR-506 inhibited the expression of LHX2, which hampered TCF4 expression and inactivated the Wnt/Beta-catenin signaling pathway, consequently inhibiting tumor growth and metastasis in NPC (2019, NA)
• The AMPK/mTOR signaling pathway in TNBC tumor growth and progression (2019, NA)
• Target network of bradycardia (2019, NA)
• Interactions of TGFB pathways, WNT, Smad and the Hippo pathway in fibrosis (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Bos taurus,Diaporthe sclerotioides,Mouse mammary tumor virus)
• TGFB1 effects on the balance between the canonical WNT/Beta-catenin pathway and PPARG (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Bos taurus,Diaporthe sclerotioides,Mouse mammary tumor virus)
• Molecular pathways of cellular senescence (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Main production and uptake mechanism of exosomes (2019, NA)
• Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases (2019, NA)
• Interaction network of proteins involved in cancer, immune system, and signal transduction pathways (2019, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human gammaherpesvirus 8,Gallid alphaherpesvirus 2,Meleagrid alphaherpesvirus 1,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Gallus gallus,NA)
• Mechanism used by EGCG to promote cancer cell growth arrest and apoptosis (2019, Malus domestica,Panax ginseng,Camellia sinensis,Salacia crassifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori,Mayaro virus)
• Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans (2019, Candida albicans,Homo sapiens)
• Immunologic Pathways in Protective versus Maladaptive Host Responses (2019, NA)
• Associated cell signaling pathway and related potential therapeutic areas (2019, Mus musculus,Rattus norvegicus,Homo sapiens,synthetic construct)
• The proposed pathway of IPs synthesis (2019, NA)
• Proposed molecular mechanisms of apoptosis and autophagy induced by BOS-93 in A549 cells (2019, Armoracia rusticana,PX clade,Rhodomela confervoides,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Schematic overview of the WNT signaling pathway (2019, Homo sapiens,Mus musculus,Clostridium perfringens)
• Exacerbation between G6PD dysfunction and neuroinflammation mediated chronic neurodegeneration (2019, NA)
• Regulated signal pathways and transcription factors of NCX1 in digestive diseases (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Callithrix jacchus,Nicotiana tabacum,Canis lupus familiaris)
• Ras/ERK signal transduction pathway with emphasis on p120-RasGAP interactions (2019, NA)
• Current Strategies for Elimination of HIV-1 Latent Reservoirs Using Chemical Compounds Targeting Host and Viral Factors (2019, NA)
• Schematic model showing the antiangiogenic and anti‐inflammatory functions of CUR in human ESCs (2019, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Malus domestica)
• Working model (2019, NA)
• Regenerative abilities contribute to the application of BM-MSC in psychocardiological disease (2019, Homo sapiens)
• Illustration of the NEK2/Beta-catenin/Myc/KDM5B/H3K4me3 pathway (2019, NA)
• PGK1 involvement in drug resistance (2019, NA)
• Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes (2019, Homo sapiens)
• Several typical post-translational modifications of PGK1 (2019, NA)
• As a tumor-suppressor gene, RASSF1A mainly acts as a crossroad of three intertwined molecular signaling mechanisms including Ras/Rho GTPases, MTs, and Hippo pathway (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Adaptive divergence of Notch signalling pathway in tiger (2019, Bos taurus,Canis lupus familiaris,Equus caballus,Felis catus,Mustela putorius furo,Panthera tigris,Panthera leo,Panthera pardus,Panthera onca,Acinonyx jubatus,Felis silvestris,Panthera tigris altaica,Panthera tigris tigris,Mustela putorius,Panthera uncia,Neofelis nebulosa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Hormone-related pathways enriched in DEGs of the brain and gonads (2019, Leptobrachium leishanense,Homo sapiens)
• Apoptosis adapted from KEGG (ID: hsa04210), the know targets were signed in red; (B,C) the insulin signaling pathway adapted from KEGG (ID: hsa04910) the predicted targets and other human proteins were signed in red (2019, NA)
• Differences in the functional impact of IL-7/IL-7R-mediated signaling in T-ALL cells and their normal counterparts (2019, Homo sapiens,Mus musculus,Catopsilia pomona)
• Signaling transduction of mTOR pathway (2019, Homo sapiens,Mus musculus,Molva molva)
• Schematic view of the AP-1 and PKB signaling pathways between MSCs and HCC cells in inflammation microenvironment (2019, NA)
• Schematic view of the TLR4 signaling pathways between MSCs and HCC cells in inflammation microenvironment (2019, NA)
• Schematic view of the Wnt signaling pathways between MSCs and HCC cells in inflammation microenvironment (2019, NA)
• Wnt/Beta-catenin signaling pathway (2019, Lareunionomyces loeiensis,Curcuma longa,Ginkgo biloba,Cannabis sativa,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Metabolic pathway of DEGs related to lipid metabolism in the liver by DNA microarray analysis (2019, NA)
• Oxidative stress and vascular implications in metabolic syndrome (2019, Saccharomyces cerevisiae,Oryza sativa,Zea mays,Olea europaea,Vitis vinifera,Citrus limon,Alpinia zerumbet,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,gut metagenome)
• Regulating mechanism of autophagy (2019, NA)
• Models for CAN function in larval development (2019, NA)
• Representative model of the MMP-2 and MMP-9 secretion induced by leptin in a cultured model for breast cancer (2019, NA)
• Energy metabolism and lactate shuttling between astrocytes and neurons (2019, Mus musculus,Rattus norvegicus,herbal medicine,Euglena gracilis,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,West Nile virus)
• Major phospholipid biosynthetic pathways, genes involved, and subcellular localization of the encoded enzymes.PTDSS1,PCYT1A, andPISD from this study (all in red font) are associated with syndromic skeletal dysplasias (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Number of studies suggest that an increase in microbial BSH activity results in a reduction in stimulation of intestinal FXR (2019, NA)
• Retinoic acid (RA)-signaling pathway (2019, NA)
• Immune system pathways in KEGG pathway analysis (2019, Saccharomyces cerevisiae,PX clade,Phaeophyceae,Cichorium intybus,Undaria pinnatifida,Sargassum fusiforme,Eisenia bicyclis,Sargassum binderi,Bifurcaria bifurcata,Sargassum horridum,Homo sapiens,Rattus norvegicus,NA)
• Nervous system pathways in KEGG pathway analysis (2019, Saccharomyces cerevisiae,PX clade,Phaeophyceae,Cichorium intybus,Undaria pinnatifida,Sargassum fusiforme,Eisenia bicyclis,Sargassum binderi,Bifurcaria bifurcata,Sargassum horridum,Homo sapiens,Rattus norvegicus,NA)
• Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol (2019, Saccharomyces cerevisiae,PX clade,Phaeophyceae,Cichorium intybus,Undaria pinnatifida,Sargassum fusiforme,Eisenia bicyclis,Sargassum binderi,Bifurcaria bifurcata,Sargassum horridum,Homo sapiens,Rattus norvegicus,NA)
• Potential roles of aberrant activations of MAPK and PI3K signaling pathways in pathogenesis of PWS/SWS (2019, NA)
• cAMP regulates immune response of astrocytes (2019, Mus musculus,Rattus norvegicus,herbal medicine,Euglena gracilis,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,West Nile virus)
• Relationship between autophagy and cytokines (2019, NA)
• The proposed mechanism by which T (2019, Toxoplasma gondii,Homo sapiens)
• Mutant proteasomes from CANDLE/PRAAS subjects have a potential pro-inflammatory potential due to the negative impact they exert on mTORC1 (2019, Human alphaherpesvirus 1,West Nile virus,Coxsackievirus B3,Semliki Forest virus,Transmissible gastroenteritis virus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,NA)
• Defective proteasomes in CANDLE/PRAAS subjects provoke ER stress and trigger the so-called unfolded protein response (UPR) which is associated with inflammation (2019, Human alphaherpesvirus 1,West Nile virus,Coxsackievirus B3,Semliki Forest virus,Transmissible gastroenteritis virus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,NA)
• Summary of changes to the Wnt pathway as a result of AD + TS treatment (2019, NA)
• Visual representation of molecular interactions in the HSF flock (2019, Haemonchus contortus,Homo sapiens)
• Caffeine, theanine and catechin biosynthetic pathways in plants, and expression patterns of genes related to quality metabolites in ‘Xiaoxueya’ leaves (2019, NA)
• Visual representation of molecular interactions in the TSF flock (2019, Haemonchus contortus,Homo sapiens)
• Altered cancer pathways in ASL, CCA and HCC (2019, Homo sapiens,Mus musculus,Fasciola hepatica)
• Schematic view of the ERK pathway in response to growth factors, hormones, and mechanical stress (2019, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Danio rerio,Cyprinus carpio,Panthera pardus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Molecular mechanisms of adipogenesis (2019, NA)
• Cend1 induces the p53-Cyclin D1-pRb signaling pathway resulting in cell cycle arrest at the G1/G0 phase of the cell cycle (2019, NA)
• MiRNA-gene-pathway interactive map (2019, NA)
• mTOR Signaling Pathway (2019, Escherichia coli,Bacteroides fragilis,Fusobacterium nucleatum,Helicobacter hepaticus,bacterium B,gut metagenome,human metagenome,metagenomes,Homo sapiens,Mus musculus)
• Notch, PI3K, TGFB, Wnt/B-catenin, and EGFR/Ras signaling pathways are interacting with each other (2019, NA)
• Notch signaling pathways in CRC (2019, NA)
• Mechanism of whey protein/resistance training to induce muscle protein synthesis (2019, NA)
• EGFR and PI3K signaling pathways in CRC (2019, NA)
• Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae (2019, Escherichia coli,Escherichia coli DH5alpha,Mycobacterium marinum,Mycobacteroides abscessus,Mycolicibacterium fortuitum,Flavobacterium columnare,Edwardsiella ictaluri,Mycobacteroides chelonae,Mycobacterium haemophilum,Mycolicibacterium peregrinum,Bos taurus,Oryctolagus cuniculus,Capra hircus,Eucalyptus intertexta,Ichthyophthirius multifiliis,Myxidium streisingeri,Pleistophora hyphessobryconis,Homo sapiens,Mus musculus,Danio rerio,Infectious spleen and kidney necrosis virus)
• Signaling pathway with involvement of RASSF1A (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Drosophila melanogaster,Mesomycoplasma hyorhinis)
• Mechanism of suppression of FN-induced EMT by cirsiliol in B16F10 metastatic melanoma cells (2019, Arachis hypogaea,Curcuma longa,Artemisia scoparia,Centaurea jacea,Achillea fragrantissima,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens)
• DUBs and their role in Hippo signaling (2019, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• Hippo signaling pathway (2019, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• DUB family members (2019, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• PI3K/mTOR signaling cascade (2019, NA)
• Canonical KEAP1/NFE2L2 antioxidant signalling pathway, induced by electrophilic ligands (2019, NA)
• Roles of non-canonical Wnt pathways in osteoclast differentiation and function (2019, Mus musculus,Rattus norvegicus,Human immunodeficiency virus,Mouse mammary tumor virus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Wnt signal transduction (2019, Mus musculus,Rattus norvegicus,Human immunodeficiency virus,Mouse mammary tumor virus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Wnt signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic diagram showing molecular mechanism of SC in varicocele-induced testicular dysfunction in male SD rats (2019, Schisandra chinensis,Homo sapiens)
• Canonical pathway explaining the NASH progression from steatosis to hepatocellular carcinoma (2019, Candida dubliniensis,Bikinia letestui,Homo sapiens,Mus musculus)
• Cell signaling pathways activated in osteogenesis and angiogenesis models: Wingless-related integration site (Wnt) pathway, bone morphogenetic protein (BMP) pathway, and fibroblast growth factor (FGF)/platelet-derived growth factor (PDGF) pathway (2019, NA)
• Cellular effects of extracellular ADO in the regulation of lymphocyte functions (2019, NA)
• Extracellular ADO on subsets of macrophages (2019, NA)
• Extracellular and intracellular (canonical and non-canonical) adenosinergic pathways (2019, NA)
• G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules (2019, NA)
• Agonist (e.g., histamine) binds histamine receptors (2019, NA)
• Agonist (e.g., bradykinin) binds bradykinin receptors (2019, NA)
• Agonist (e.g., dopamine) binds dopamine receptors (2019, NA)
• Agonist (e.g., serotonin) binds serotonin receptors (2019, NA)
• Agonist (e.g., epinephrine, norepinephrine) binds adrenergic receptors (2019, NA)
• Agonist (e.g., acetylcholine, carbachol, pilocarpine, etc.) binds muscarinic receptors (2019, NA)
• Acute lung injury and autophagy pathway (2019, NA)
• Pulmonary arterial hypertension and autophagy pathway (2019, NA)
• Infectious lung disease and autophagy pathway (2019, NA)
• Lung cancer and autophagy pathway (2019, NA)
• COPD and autophagy pathway (2019, NA)
• TSC2 mediated crosstalk between the Akt/mTOR pathway and the cyclin D1-CDK4/6 axis.The cyclinD1/CDK4/6 axis is responsible for increased phosphorylation TSC2 and TSC1, and promotes the phosphorylation of the mTOR substrates, 4E-BP1 and S6K1 (2019, NA)
• Biochemical pathway in neutrophils showing the signaling cascade and the effects related to DAG and PA activation (2019, Mus musculus,Cavia porcellus,Homo sapiens)
• Biochemical pathway showing the interplay between different actors in DAG and phosphatidic acid signaling (2019, Mus musculus,Cavia porcellus,Homo sapiens)
• Main signalling pathways of programmed necrosis in cardiomyocytes (2019, NA)
• Two‐signal model of inflammasome signaling (2019, NA)
• Ezrin, more than a metastatic detERMinant? (2019, NA)
• EtOAc extract of L (2019, Leathesia difformis,Armoracia rusticana,PX clade,Punica granatum,Phaeophyceae,Saccharina japonica,Undaria pinnatifida,Fucus vesiculosus,Ecklonia cava,Sargassum fusiforme,Eisenia bicyclis,Ishige okamurae,Sargassum siliquastrum,Kaempferia galanga,Sargassum serratifolium,Ishige foliacea,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Danio rerio,Corynephage beta,NA)
• THD on a crosstalk in Fzd/GSK3B/Beta-catenin/P62 axis (2019, NA)
• Protein–protein interaction network of the differentially expressed proteins between IH-exposed HUVECs treated with or without estradiol (E2) (2019, NA)
• PLNet2: LocPL pathway reconstructions (first 100 paths) (2019, Homo sapiens,Saccharomyces cerevisiae,Venustaconcha ellipsiformis)
• Interactions between EV-A71 and the type I IFN- signaling pathway (2019, NA)
• Comparison of HTRgene results to known biological pathways for cold and heat stress (2019, NA)
• Diagrammatic representations of putative mechanisms of microRNA 375 in regulating metadherin-induced cell proliferation, cell migration, and angiogenesis in human colorectal cancer (2019, NA)
• Effects of hydrostatin-SN10 on the JAK2/STAT3 signaling pathway (2019, NA)
• Role of MYOF in EGFR-related pathway (2019, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Homo sapiens,Mus musculus)
• Toxic function evaluation in cancer EVs (2019, Homo sapiens)
• DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency (2019, NA)
• Polycystin-associated pathogenic mechanisms in human diseases (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasis (2019, Homo sapiens)
• Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells (2019, Homo sapiens,Petroselinum crispum)
• Whole Transcriptomic Analysis of Apigenin on TNFA Immuno-activated MDA-MB-231 Breast Cancer Cells (2019, Homo sapiens,Petroselinum crispum)
• Analysis of miRNA expression profiles in the liver of Clock-delta19 mutant mice (2019, NA)
• Proposed schematic diagram of LPS-induced ROS-mediated neuroinflammation, neurodegeneration, and memory deficits via dysregulation of the JNK/NFKB/Akt signaling pathway (2019, Armoracia rusticana,Olea europaea,Diospyros kaki,Mus musculus,Rattus norvegicus,Homo sapiens)
• MTOR signaling pathway is involved in liver IR injury and plays crucial roles in autophagy (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Scheme of the mechanisms in the protective effect of nerolidol on LPS-induced ALI (2019, Armoracia rusticana,Zingiber officinale,Melaleuca alternifolia,Zingiber zerumbet,Chenopodium album,Amaranthus retroflexus,Cinnamomum chartophyllum,Peperomia serpens,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,unidentified,Trypanosoma evansi)
• CRPC development (2019, NA)
• Neutrophil immunometabolism in cystic fibrosis (2019, Homo sapiens,Mus musculus)
• Proteins and metabolites in JK1 that change by >2-fold relative to wild-type E (2019, Escherichia coli,Homo sapiens)
• Tobacco-smoking associated genes map to interconnected interferon and stress response signaling networks (2019, NA)
• Immunomodulating effects of SCFAs (2019, Faecalibacterium prausnitzii,Akkermansia muciniphila,Bifidobacterium adolescentis,Ruminococcus gnavus,Roseburia intestinalis,Methanobrevibacter smithii,Roseburia hominis,Dialister invisus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,gut metagenome,Punica granatum)
• Network visualization of pathways enriched with genes influencing non-platinum-based treatment response in oral cancer.Hexagon shapes are genes (2019, NA)
• Network visualization of pathways enriched with genes influencing platinum-based treatment response in oral cancer.Hexagon shapes are genes (2019, NA)
• Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study (2019, NA)
• Transcriptomic Pattern of Genes Regulating Protein Response and Status of Mitochondrial Activity Are Related to Oocyte Maturational Competence—A Transcriptomic Study (2019, NA)
• Effects of abnormal DA release and stimulation of DA receptors on proteasome and autophagy (2019, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Callithrix jacchus,Euphilotes enoptes,Saccharomyces cerevisiae,Equus caballus,prion)
• ERK/MAPK signaling pathway in liver metastasis of colorectal cancer (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Citrus macrophylla,Homo sapiens,Mus musculus)
• Wnt signaling deregulation in the aging brain and in AD (2019, NA)
• Probable mechanisms of action of IGFBP-2 in the CNS (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Ginkgo biloba)
• Most significant module of PPI network of DEPs involved in ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathway (2019, Armoracia rusticana,Candida dubliniensis,Homo sapiens,Clonorchis sinensis)
• Comparing ECM-receptor interaction pathway for (a) DA and (b) non-DA neurons based on DEGs and DEmiR (2019, Nicotiana tabacum,Iris germanica,Homo sapiens,Rattus norvegicus)
• PI3K-Akt signaling pathway changed in FSH-positive relative to negative NFPAs (2019, Armoracia rusticana,Candida dubliniensis,Homo sapiens,Clonorchis sinensis)
• Hh signaling pathway transduction (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori,Lareunionomyces loeiensis,Paraechinus aethiopicus,Paracentrotus lividus)
• Cellular context of TLR5 engagement by UPEC FliC in the bladder leading to early IL-10 induction (2019, Escherichia coli,Homo sapiens)
• Circular RNAs Regulate Cancer Onset and Progression via Wnt/Beta-Catenin Signaling Pathway (2019, NA)
• The Action circTTN Competitively Sponging miR-432 Mediating Myoblast Proliferation and Differentiation (2019, NA)
• Animal cell cytokinesis (2019, Drosophila melanogaster,Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Trypanosoma brucei,Leishmania donovani,Plasmodium berghei,Entamoeba histolytica,Giardia intestinalis,Cryptosporidium parvum,Leishmania mexicana,Leishmania infantum,Trichomonas vaginalis,Tetrahymena thermophila,Glossina morsitans,Amoebozoa,Alveolata,Nymphalis io,Eimeria tenella,Theileria parva,Botrynema brucei,Theileria annulata,Nucula nucleus,Tetrahymena pyriformis,Entamoeba invadens,Naegleria gruberi,Eimeria maxima,Babesia microti,Trypanosoma evansi,Trypanosoma congolense,Ichthyophthirius multifiliis,Trypanosoma vivax,Parabasalia,Naegleria fowleri,Ixodidae,Trypanosoma equiperdum,Eimeria bovis,Eimeria vermiformis,Tritrichomonas foetus,Hyalomma excavatum,Tetrahymena sp.,Sarcocystis neurona,Archamoebae,Trypanosoma lewisi,Balantioides coli,Trypanosoma evansi evansi,Eimeria crandallis,Tetrahymena empidokyrea,Saccharomyces cerevisiae,Bos taurus,Canis lupus familiaris,Sus scrofa,Ovis aries,Embryophyta,Equus caballus,Schizosaccharomyces pombe,Felis catus,Chlorophyta,Opisthokonta,Tanacetum vulgare,Mus musculus,Rattus norvegicus,Homo sapiens,Poecilia reticulata,NA)
• Roles of CAFs in drug resistance (2019, NA)
• Proposed mechanisms for the role of MC mediators in response to tumor cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Molecular mechanisms of p53 loss of heterozygosity in breast cancer in response to DNA damage (2019, NA)
• Signaling role for chloride in the bidirectional communication between neurons and astrocytes (2019, NA)
• Myostatin signaling pathway in sarcopenia (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Representative cardiovascular disease pathway (2019, Nicotiana tabacum,herbal medicine,Allium cepa,Salvia miltiorrhiza,Allium sativum,Ginkgo biloba,Zingiber officinale,Panax notoginseng,Cinnamomum verum,Citrus limon,Thymus vulgaris,Origanum vulgare,Syzygium aromaticum,Lavandula angustifolia,Mentha x piperita,Trigonella foenum-graecum,Ligusticum sinense,Myristica fragrans,Piper nigrum,Piper methysticum,Alpinia zerumbet,Thymus mongolicus,Oncorhynchus mykiss,Salmo trutta,Hoplerythrinus unitaeniatus,Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Venustaconcha ellipsiformis)
• Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways (2019, Homo sapiens,Mus musculus,Candida dubliniensis)
• NLRC5’s role in renal diseases (2019, NA)
• Chronic inflammation in MetS and skin diseases (2019, Homo sapiens,Mus musculus,Meleagris gallopavo,Cutibacterium acnes)
• Insulin signaling and insulin resistance in MetS and skin diseases (2019, Homo sapiens,Mus musculus,Meleagris gallopavo,Cutibacterium acnes)
• Coral2 module-based phosphatidylinositol (PI) signaling system networks (2019, Gloiopeltis furcata,Homo sapiens)
• Schematic diagram showing molecular mechanism of varicocele-induced testicular dysfunction and its prevention by MAS (2019, Allium cepa,Gynochthodes officinalis,Cuscuta chinensis,Cuscuta chinensis var. chinensis,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens)
• Schematic of the components of the integrated model (2019, Homo sapiens,Eucalyptus intertexta)
• Representative liver disease pathway (2019, Nicotiana tabacum,herbal medicine,Allium cepa,Salvia miltiorrhiza,Allium sativum,Ginkgo biloba,Zingiber officinale,Panax notoginseng,Cinnamomum verum,Citrus limon,Thymus vulgaris,Origanum vulgare,Syzygium aromaticum,Lavandula angustifolia,Mentha x piperita,Trigonella foenum-graecum,Ligusticum sinense,Myristica fragrans,Piper nigrum,Piper methysticum,Alpinia zerumbet,Thymus mongolicus,Oncorhynchus mykiss,Salmo trutta,Hoplerythrinus unitaeniatus,Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Venustaconcha ellipsiformis)
• PPI network and module analysis (2019, NA)
• Construction of pathway map and PPI interaction map (2019, Homo sapiens,Caenorhabditis elegans)
• HIF-mediated suppression of ROS (2019, Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Rickettsia prowazekii)
• Long non-coding RNA TCONS_00000200 as a non-invasive biomarker in patients with intracranial aneurysm (2019, NA)
• Hereditary systemic autoinflammatory diseases and Schnitzler’s syndrome (2019, Homo sapiens,Mus musculus)
• Astaxanthin improves insulin sensitivity and glucose uptake (2019, NA)
• FGFR pathway.FGFRs dimerize upon ligand building and trigger a downstream cascade of signaling pathways (2019, NA)
• Predicted localization of proteins and biosynthetic pathways in Synechocystis (2019, NA)
• Proposed model for the role of TLR-mediated innate immune events in regulating the Th1/Th17 and Th2 immune balance (2019, NA)
• MyD88-dependent and TRIF-dependent TLR signaling pathways (2019, NA)
• Suggested mechanism by which L (2019, Escherichia coli,Lactiplantibacillus plantarum,Lactobacillus acidophilus,Limosilactobacillus fermentum,Escherichia coli Nissle 1917,Lactobacillus delbrueckii,Pediococcus pentosaceus,Limosilactobacillus reuteri I5007,Saccharomyces cerevisiae,Armoracia rusticana,Glycine max,Homo sapiens,Gallus gallus,Sus scrofa,Pieris brassicae)
• The endocytosis pathway (2019, Alexandrium minutum,Homo sapiens)
• Schematic view of microglial activation and cross-talks between microglia and other immune factors in the pathogenesis of Parkinson’s disease (2019, NA)
• Canonical WNT/Beta-catenin pathway, Warburg glycolysis, and cancer (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• WNT/Beta-catenin, TGFB1, PI3K-AKT, SMAD, and PPARG pathways (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Canonical WNT/Beta-catenin pathway: “on” and “off” states (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis of the target genes of CTD-2357A8.3 in HNSCC tissues (2019, Homo sapiens)
• Mammalian or mechanistic target of rapamycin (mTOR) complexes and signaling pathway of mTORC1 and mTORC2 (2019, Homo sapiens)
• The JAK-Stat signalling pathway (2019, Homo sapiens,Human alphaherpesvirus 3)
• Schematic depiction of the mTOR signaling network (2019, NA)
• Cross talk between induction of mitochondrial oxidative/nitrosative stress and autophagy (2019, NA)
• STRING analysis of integrin signaling pathways and response to wound healing pathways (2019, Armoracia rusticana,Human gammaherpesvirus 4,Human immunodeficiency virus,Sequoia sempervirens,Human parvovirus B19,Echium plantagineum,Homo sapiens,Mus musculus,Equus caballus,Treponema pallidum,NA)
• PPI network analysis (2019, NA)
• LKB1 loss alters cancer cell biology (2019, NA)
• LKB1-proficient tumors display coordinated control of metabolism, DNA repair, and mitochondrial dynamics (2019, NA)
• Molecules associated with ‘focal adhesion’ pathway (2019, NA)
• Wnt signaling pathways (2019, NA)
• Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells (2019, NA)
• Schematic presentation of the signaling pathways involved in resistin-induced angiogenesis in human osteosarcoma cells (2019, NA)
• Functional enrichment analysis and construction of PPI network (2019, Homo sapiens,Mus musculus,NA)
• Ras signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Gluconeogenesis pathway in glucose deprived lung cancer cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Malus domestica,NA)
• Glycolysis and biosynthetic pathways emanating from glycolysis (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Malus domestica,NA)
• RAS-ERK signaling pathway and associated disorders (2019, NA)
• Non small cell lung cancer KEGG pathway (2019, NA)
• Simplified pathway model (2019, NA)
• Non small cell lung cancer pathway logic circuit with miRNA (2019, NA)
• Non small cell lung cancer pathway circuit (2019, NA)
• YAP regulation by focal adhesion signaling (2019, NA)
• YAP regulation by mechanical stimuli (2019, NA)
• Short- and long-term action of ceramides on insulin signaling in muscle cells (2019, NA)
• For using mTOR in PD treatment (2019, NA)
• Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels (2019, NA)
• Differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation (2019, Homo sapiens,Rattus norvegicus,Dryas iulia)
• Schematic overview of the autophagy process and genetic and drug targets to inhibit specific aspects of autophagy (2019, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Pathways controlling the response of physioxia MSC chondrogenesis (2019, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• One proposed mechanism for how vascular endothelial growth factor/neuropilin (VEGF/NRP) signaling impacts cancer stem cell (CSC) function independently of VEGFRs (2019, Homo sapiens,Mus musculus,Aphyosemion alpha)
• Summary diagram demonstrating the contribution of IGF-1/IGFBP to transcriptional levels of PPARG, VEGF, and HIF-1A under the administration of BV intervention (2019, NA)
• IRAK1 kinase drives distinct prosurvival responses to microbial infection and ionizing radiation (2019, NA)
• Activation of signaling pathways in respiratory epithelial cells upon viral infection (2019, NA)
• Core genes involved in the promotion of depression in patients with ovarian cancer (2019, NA)
• Proposed model for the interaction between miR-30a-5p, CD73, and TNFR2 and inhibition of the AKT/ERK pathway to induce G0/G1 phase arrest (2019, NA)
• Pancreatic cancer cell proliferative arrest caused by PTP1B inhibition (2019, NA)
• Conflicting roles of RASAL2 in different cancers (2019, NA)
• Metabolic pathway of n-alkanes and the enzymes implicated in oxidation and hydroxylation processes in Y (2019, Yarrowia lipolytica)
• (A–C) The most significance predictive genes for renal ischemia-reperfusion injury (IRI) in the rat model (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Angelica sinensis)
• Toll-like receptors (TLRs) in Lamellibrachia luymesi (2019, NA)
• HCC microenvironment inhibits SIRT4 expression in TAMs and modulates alternative activation of TAMs, which contributes to HCC development (2019, Homo sapiens,Mus musculus,Sus scrofa)
• SPRY-altered signaling network profiles in mammary stromal fibroblasts (2019, Drosophila melanogaster,Venustaconcha ellipsiformis,Homo sapiens,Mus musculus,Adenoviridae,Agriosomyces longus)
• IPA® analysis of signalling pathways of the genes differentially expressed upon lysozyme treatment (2019, NA)
• Signaling pathways and therapeutic targets (2019, NA)
• Gut dysbiosis/permeability increase circulating LPS and exosomal HMGB1, leading to TLR activation in microglia and the induction of iNOS and superoxide (2019, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus,gut metagenome,Human gammaherpesvirus 4)
• Estrogen biogenesis, and its metabolism (2019, NA)
• Pathways activated by several dysregulated hormones in central obesity (2019, NA)
• Schematic model (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,synthetic RNA)
• GBM induction of PD-L1 secretion (2019, Homo sapiens,Mus musculus,Candida dubliniensis)
• PrRP physiological functions and signaling—summary (2019, Gallus gallus,Danio rerio,Xenopus laevis,Cyprinus carpio,Carassius auratus,Periophthalmus kalolo,Periophthalmus modestus,Carassius langsdorfii,Mus musculus,Rattus norvegicus,Cricetulus griseus,Venustaconcha ellipsiformis,Sar,Dirofilaria ursi,Homo sapiens,Bos taurus)
• Summary of altered metabolic pathways and regulatory mechanism of rFIP-nha against A549 cells (2019, Nicotiana tabacum,Ganoderma lucidum,Flammulina velutipes,Ganoderma microsporum,Ganoderma sinense,Ganoderma tsugae,Stachybotrys chlorohalonata,Homo sapiens,NA)
• Complement lectin pathway activation (2019, Mus musculus,Rattus norvegicus,Armoracia rusticana,Agriosomyces longus,Homo sapiens,Venustaconcha ellipsiformis)
• Adaptive feedback signaling in BRAF V600E-mutated mCRC (2019, Homo sapiens,Mus musculus,Bikinia letestui)
• The potential role and mechanisms of icariin in HG-induced EPC dysfunction (2019, NA)
• Apoptosis pathway in LNCaP cells treated with LEP (1 × 10−6 M) (2019, NA)
• p53 signaling pathway in LNCaP cells treated with LEP (1 × 10−6 M) (2019, NA)
• Antidepressant-like effects and mechanisms of GXDSF via mediation of the CaMKII-CREB-BDNF signalling pathway in chronic unpredictable mild stress (CUMS)-induced depressive rats (2019, NA)
• Pathway analysis network of 131 preliminary potential genes (2019, Homo sapiens)
• TRK signalling pathway (2019, NA)
• NLR-dependent regulation of MHC class I antigen presentation (2019, Homo sapiens,Mus musculus,Vaccinia virus)
• Warburg's theory that cancer cells depend on aerobic glycolysis led to the assumption that OXPHOS is downregulated in cancer (2019, Homo sapiens,Mus musculus)
• Activation of the KEAP1-NRF2 and HSF1 pathways by electrophilic lipoxidation products (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Xenopus laevis)
• Redox Regulation in Glucose Metabolism (2019, NA)
• Redox regulation of IRE1A to control UPR (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• Redox regulation of apoptosis under ER stress (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• UPR pathway under ER stress (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• Basic metabolic pathways used in T cells (2019, Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,Human gammaherpesvirus 4,NA)
• Cancer pathway analysis of DEPs (2019, NA)
• Multifunctional neuron-specific enolase: its role in lung diseases (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Trypanosoma brucei,Euglena gracilis,Mastigamoeba balamuthi,Homo sapiens,Streptococcus pneumoniae)
• The association between bacterial translocation hypothesis and related traits of Crohn’s disease in the pathophysiology of chronic fatigue syndrome (2019, Lactobacillus acidophilus,Lactobacillus delbrueckii subsp. bulgaricus,Bifidobacterium bifidum,Homo sapiens,gut metagenome,Human alphaherpesvirus 3)
• Representative pathway featuring multiple enzyme-/non-enzyme-assisted post-translational modifications (PTMs) that control cell-decision making (2019, NA)
• IPA to identify the signaling pathway associated with the differentially expressed proteins across all the conditions studied (2019, NA)
• TRPV1 activates a complicated pathway that converges on NR1 trafficking in remifentanil-induced postoperative hyperalgesia.Notes: Schematic illustration of proposed TRPV1-CaMKII/PKC-NR1 signaling in remifentanil-induced postoperative hyperalgesia (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Castor fiber,Homo sapiens)
• Intrinsic and extrinsic pathways of neutrophil apoptosis (2019, NA)
• Schematic overview of steroidogenesis and corresponding urine steroid metabolites (2019, NA)
• MDC1 loss causes greater IR sensitivity than H2AX loss (2019, Homo sapiens,Mus musculus,Escherichia coli,vectors)
• Comparative analysis of genes in regeneration-related signaling pathways of regenerative animals (2019, Apostichopus japonicus,Homo sapiens)
• Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease (2019, NA)
• Chronic obstructive pulmonary disease (2019, NA)
• Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease (2019, NA)
• Simplified Version of the Canonical Wnt/ Beta-Catenin Pathway (2019, Nicotiana tabacum,Oryza sativa,Glycine max,Malus domestica,Panax ginseng,Cucumis sativus,Curcuma longa,Brassica oleracea,Allium cepa,Allium sativum,Daucus carota,Zingiber officinale,Catharanthus roseus,Ipomoea batatas,Petroselinum crispum,Salvia rosmarinus,Linum usitatissimum,Apium graveolens Dulce Group,Origanum vulgare,Piper betle,Curcuma mangga,Mus musculus,Rattus norvegicus,Homo sapiens)
• Modules of core PPI networks of baicalein against HCC (2019, herbal medicine,Scutellaria baicalensis,Homo sapiens,Rattus norvegicus,Hepatitis B virus,Cerobasis alpha,NA,NA)
• The melanogenesis pathway shows where common ENAMs affect the pathway (2019, NA)
• TGFB signaling pathway and its role in tumor immune microenvironment (2019, Homo sapiens,Mus musculus,gut metagenome)
• Target-pathway network analyses results (2019, NA)
• De novo biosynthesis of various aromatic compounds derived from the SHK and aromatic amino acid biosynthesis pathway (2019, NA)
• Schematic overview of androgen biosynthesis (2019, Rattus norvegicus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Danio rerio,gut metagenome,Clostridium scindens,NA)
• Coexpression network was constructed by WGCNA (2019, Agaricus bisporus,Auricularia auricula-judae,Vanderbylia robiniophila,Homo sapiens,Mus musculus)
• The E-cadherin (E-cad) interactions and signaling pathway (2019, NA)
• BRD4 is involved in the transforming growth factor B (TGF-ß)/SMAD signaling pathway (2019, NA)
• Gene expression profiles of the PI3K-AKT signaling pathway in treated HepG2 cell (2019, Camellia sinensis,Swertia chirayita,Swertia mussotii,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulatory roles of lncRNAs in TAM polarization (2019, NA)
• Recognition of HSV-1 infection by pattern recognition receptors (PRRs) (2019, NA)
• Proposed signaling pathway of this study (2019, NA)
• Simplified scheme of core steroidal glycoalkaloid modification in tomato and potato species (2019, NA)
• MicroRNA Regulatory network with miRs from the anti-survival/EMT group (2019, Homo sapiens,Mus musculus,Armoracia rusticana,Ornithorhynchus anatinus)
• Metabolic engineering approaches to microbial production of SHK pathway derivatives (2019, NA)
• Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways (2019, Rattus norvegicus,Homo sapiens)
• Metabolic engineering approaches to microbial production of aromatic amino acid derivatives (2019, NA)
• The regulation of the expression of ZNF638 in response to thermogenic cues (2019, NA)
• Inhibitors and mutants of the histidine biosynthesis pathway (2019, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Zea mays,Glycine max,Schizosaccharomyces pombe,Brassica napus,Ricinus communis,Nakaseomyces glabratus,Trifolium repens,Nicotiana plumbaginifolia,Ipomoea purpurea,Escherichia coli,Homo sapiens)
• Molecular pathway signaling of angiogenesis-induced epithelial-mesenchymal transition in hepatocellular carcinoma (2019, NA)
• Antifracture pathways of potential targets for treating fracture from main active ingredients of Drynariae Rhizoma (2019, NA)
• Sperm structure and energy production mechanisms in the sperm cytoplasm and mitochondria (2019, NA)
• Illustration representing the mechanisms of compound 1-induced human breast cancer cell apoptosis (2019, Armoracia rusticana,Oryza sativa,Houttuynia cordata,Uvaria argentea,Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathway of the Akt + diuron-induced glioma (2019, NA)
• Mechanism scheme uncovers that CRISPR/Cas9-mediated knockout of NSD1 promotes H3K27me3 methylation and inhibits Wnt10b transcription, thereby suppressing activation of the Wnt/Beta-catenin signaling pathway (2019, NA)
• Running young is more effective than running at midlife (2019, Homo sapiens,Mus musculus)
• PH-EPS modulates the activation of RAW264.7 cells through the TLR4(Dectin-1)/NFKB/MAPK pathway (2019, NA)
• Study on the mechanism of the MPAPO promoting of corneal wound repair and axonal regeneration (A) MPAPO activates the classic Wnt/Beta-catenin signaling pathway through the PAC1 receptor (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana,Ctenopharyngodon idella)
• CMTM7 activates Rab5 which controls the fusion of early endosomes and affects EGFR protein trafficking, an essential part of the PI3K/AKT signaling pathway (2019, NA)
• Graphical abstract of how EGFR signaling pathway and downstream effector inhibit the miR-124a expression and the role of ETS2 in insulin production in pancreatic beta cells (2019, NA)
• Schematic representation of TLR and JAK-STAT pathways postulated in the slug I (2019, Drosophila melanogaster,Caenorhabditis elegans,Crassostrea gigas,Penaeus vannamei,Pinna nobilis,Patinopecten sp.,Aplysia californica,Mytilus galloprovincialis,Penaeus monodon,Apostichopus japonicus,Lymnaea stagnalis,Mizuhopecten yessoensis,Azumapecten farreri,Crassostrea virginica,Pinctada imbricata,Ruditapes philippinarum,Portunus trituberculatus,Biomphalaria glabrata,Haliotis discus hannai,Argopecten irradians,Anadara broughtonii,Bathymodiolus azoricus,Tegillarca granosa,Chlamys nipponensis,Cyclina sinensis,Saccostrea glomerata,Dicathais orbita,Pinctada maxima,Crassostrea hongkongensis,Haliotis discus discus,Pinctada margaritifera,Haliotis discus,Haliotis midae,Rapana venosa,Physella acuta,Deroceras reticulatum,Solen grandis,Corbicula fluminea,Radix auricularia,Oncomelania hupensis,Fabriciana nerippe,Cybister chinensis,Aegista chejuensis,Plectotropis quelpartensis,Ellobium chinense,Cristaria plicata,Colletes inaequalis,Nodipecten subnodosus,Satsuma myomphala,Cybister japonicus,Meghimatium fruhstorferi,Atrina pectinata,Stylommatophora,Diaporthe sclerotioides,Matthiola incana,Cucumis sativus,Listeria monocytogenes,Triportheus paranensis,Vibrio parahaemolyticus,Epinephelus tauvina,Homo sapiens,Mus musculus,Paraechinus aethiopicus,transposons,Satellites,NA)
• Proposed model for apoptosis suppression via R-Ras pathway by RasGRP2 (2019, Homo sapiens,Mus musculus,Xenopus laevis)
• Amyloidogenesis and the influence of lipid managing proteins (2019, Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Sus scrofa)
• Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Vaccinated Subjects (–) (2019, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza B virus BShanghai3612002,Homo sapiens,Mus musculus,Canis lupus familiaris,Streptococcus pneumoniae)
• Highlighted NF-Kappa B Signaling KEGG Pathway (hsa04040) with Enriched Genes from the LRT Analysis (Bonferroni-adjusted p < 0.05) for Influenza Infected Subjects (–) (2019, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza B virus BShanghai3612002,Homo sapiens,Mus musculus,Canis lupus familiaris,Streptococcus pneumoniae)
• GABABR signaling model (2019, NA)
• Schematic overview depicting regulatory pathways for PYY and GLP-1 secretion by enteroendocrine L-cell (2019, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Limosilactobacillus reuteri,Faecalibacterium prausnitzii,Akkermansia muciniphila,Bacteroides thetaiotaomicron,Clostridioides difficile CD3,Bifidobacterium animalis subsp. lactis,Eubacterium rectale,Lactobacillus delbrueckii,Roseburia intestinalis,Anaerobutyricum hallii,Clostridium leptum,Methanobrevibacter smithii,Ruminococcus bromii,Clostridium symbiosum,Clostridioides difficile CD68,gut metagenome,human gut metagenome,human metagenome,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Danio rerio,Hordeum vulgare)
• GPCR/Beta-arr-dependent signal pathways controlling cell survival, cytoskeleton remodeling, and gene expression, leading to enhanced cell growth, invasion and metastasis (2019, NA)
• Proposed molecular model of non-coding RNAs involved in CXCL12/CXCR4-induced CRC invasion and progression (2019, NA)
• JAK inhibitors: do they bring a paradigm shift for the management of rheumatic diseases? (2019, NA)
• Anchorage-dependent regulation of cell survival and glucose metabolism (2019, NA)
• Inhibitory effect of miRNAs on their target molecules in the UPS pathway (2019, Candida dubliniensis,Hordeum vulgare,Brucella abortus,Cutibacterium acnes,Burkholderia pseudomallei,Pleistophora sp. 3,Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,prion,NA,NA)
• Comparison of central metabolic features of the Rifle comammox Nitrospira (2019, Helicobacter pylori,Thermus thermophilus,Enterococcus hirae,Nitrosomonas europaea,Rhodococcus rhodochrous,Nitrospira sp.,Nitrospina gracilis,Hydrogenobacter thermophilus TK-6,Candidatus Nitrospira inopinata,Nitrospira moscoviensis,Nitrospira lenta,Nitrosomonas nitrosa,metagenome,metagenomes,activated sludge metagenome,Homo sapiens,Neoglyphea inopinata)
• Part of the central carbon metabolism network (CCM) in Mtb (2019, Mycobacterium tuberculosis,Homo sapiens)
• Pathways in the pathogenesis of PSO (2019, NA)
• Molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• MiR‐24‐3p regulates cell proliferation and milk protein synthesis in mammary epithelial cells through cooperatively acting with MEN1/menin (2019, NA)
• Silencing of SPARC represses heterotopic ossification via inhibition of the MAPK signaling pathway (2019, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Armoracia rusticana,Coxsackievirus B3)
• PU.1 and Notch collectively determine T vs (2019, Homo sapiens,Mus musculus,NA)
• Graphic image representation of the possible mechanisms of lung inflammation in COPD involving purinergic signaling pathway (2019, NA)
• CCAT1 in human cancer (2019, NA)
• Metabolic alterations in AML blasts (2019, NA)
• The anti-TGEV effect of Lp-1s (2019, NA)
• Current translational potential and underlying molecular mechanisms of necroptosis (2019, NA)
• Pathways leading to IDO enzyme production and regulation (2019, NA)
• Resveratrol (Res)‐mediated suppression of ALI through STAT3/SOCS3 signalling (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Inhibition of leucocyte migration was included in early moderate exercise‐mediated improvement of inflammation (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori,Lareunionomyces loeiensis,Python bivittatus)
• Signal transduction pathways initiated by IL‐29 (2019, Homo sapiens,Mus musculus,Human alphaherpesvirus 1)
• How PPM1H counteracts LRRK2 signaling pathway by dephosphorylating Rab proteins (2019, Escherichia coli,Mycobacterium tuberculosis,Bacillus subtilis,Escherichia coli DH5alpha,Mus musculus,Rattus norvegicus,Agriosomyces longus,Aklioshbomyces papillarum,Homo sapiens,Ovis aries,Adeno-associated virus)
• PPARy‐mediated effects in the liver (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Adenoviridae)
• How ablation of IKBNS affects B cell activation and PC differentiation (2019, NA)
• Simplified lipid metabolic pathway in maize (2019, Arabidopsis thaliana,Zea mays,Glycine max,Embryophyta,Brassica napus,Homo sapiens,Sinorhizobium meliloti)
• Pathogenesis of antibody‐mediated rejection and potential therapeutic targets (2019, NA)
• Modeling therapy resistance via the EGFR signaling pathway (2019, Homo sapiens)
• The possible signaling pathways induced by nsPEFs in MSCs (2019, Rattus norvegicus,Homo sapiens)
• Ceramide (Cer) synthesis pathways and their cellular compartmentalization (2019, NA)
• PI3K/AKT/mTOR and ERK signalling pathways associated with cardiac hypertrophy (2019, NA)
• Notch signaling pathway as seen in the KEGG database (hsa:04330) (2019, Homo sapiens)
• Scheme illustrating the proposed mechanism by which ET-1 increases phenylephrine-induced contraction in hypertension and the effect of PPARG activation (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• 1A,25(OH)2D3 attenuates Il-6 and IL-1Beta-mediated inflammatory responses in MacCM-stimulated human white preadipocytes (2019, NA)
• Representation of signaling pathways upstream of MTORC1 (2019, NA)
• Control case interaction visualized on RPGeNet showing the connections between NRL, NR2E3 and CRX retinal transcription factors (2019, Homo sapiens,Mus musculus,Danio rerio)
• Mechanisms of action of miR-21 showing the regulation of the WNT signaling pathway in NAFLD mice (2019, NA)
• NKG2D-mediated tumor evasion (2019, NA)
• PI3K-AKT signaling pathway adapted from KEGG (ID: hsa04151) (A) the predicted targets and genes were signed in red; (B) the known targets and genes were signed in red (2019, NA)
• KEGG pathway annotations of the PI3K-Akt pathway in non-small cell lung cancer (2019, Homo sapiens)
• Different death mechanisms of liver cells are involved in the pathogenesis of liver injury induced by MNPs (2019, NA)
• Effectors downstream of MTORC1 (2019, NA)
• Phosphoproteins identified in NIL-R (R) and NIL-S (S) roots inoculated with V (2019, Gossypium hirsutum,Verticillium dahliae)
• Top three molecular networks identified by Ingenuity Pathway Analysis (IPA): (a) Network 1 (2019, NA)
• Top 18 overlapping canonical pathways visualized as a network, which shows each pathway as a single “node” colored proportionally to the Fisher’s Exact Test p-value, where brighter red indicates higher significance (2019, NA)
• Coordinated contribution of ROS and BMPs to vascular diseases (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• BMP signaling pathways (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• AMPK stimulates autophagy by phosphorylation of ULK1 at the Ser377 and Ser777 (2019, NA)
• ALDH1A1-retinoic acid-HIF-1Alpha-VEGF pathway is activated in breast cancer MCF-7 cells (A) (2019, NA)
• IL-22 signaling pathway for expression of acute phase response proteins (2019, NA)
• Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells (2019, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Diagrammatic representation of known mechanisms of action of lithium in endocrine cancers (2019, NA)
• Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae (2019, Saccharomyces cerevisiae,Homo sapiens)
• NLRP3 inflammasome pathway and potential blockade sites of various pharmacological inhibitors (2019, Escherichia coli,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Escherichia coli O157H7,Saccharomyces cerevisiae,Candida albicans,Isodon rubescens,Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,NA)
• Proposed model depicting the underlying molecular mechanism by which aqueous bark extract of T (2019, Candida dubliniensis,Candida dubliniensis CD36,Terminalia arjuna,Homo sapiens,Carnobacterium mobile)
• Levels of regulation of NKG2DL expression (2019, NA)
• Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Inflammatory disease pathway (2019, NA)
• Ingenuity pathway analysis of the significantly altered miRNA found in the follicular fluid showing that 12 of these miRNA were related to the genes involved in the Organismal Injury and Abnormalities, Reproductive System Disease pathway (2019, NA)
• Effect of andrographolide and Simvastatin on the mevalonate pathway in HL-60 leukaemia cells (2019, Mus musculus,Rattus norvegicus,Cricetus cricetus,Andrographis paniculata,Clinacanthus nutans,Homo sapiens,Porphyromonas gingivalis)
• Schematic showing the proposed dynamic changes in the localization of LHCGR, DENND1A.V2, and RAB5B in various cellular compartments (2019, Matthiola incana,Cricetulus griseus,Cricetus cricetus,Galanthus nivalis,Homo sapiens,Oryctolagus cuniculus)
• MicroRNA-182 in ovarian cancer (2019, NA)
• Canonical and non-canonical mammalian autophagy processes (2019, Leishmania major,Paracentrotus lividus,Leishmania donovani,Manduca sexta,Leishmania mexicana,Leishmania infantum,Leishmania amazonensis,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Listeria monocytogenes,Porphyromonas gingivalis,Legionella pneumophila,Coxiella burnetii,Mus musculus,Saccharomyces cerevisiae,Human alphaherpesvirus 1,Cricetulus griseus,Sindbis virus,Ogataea angusta,Homo sapiens,Canis lupus familiaris)
• Main processes involved in exercise-induced and neurotrophin-mediated increased viability of dopaminergic neurons (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Adenoviridae)
• Signaling pathways in osteoclast (OC) differentiation, survival and death (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Betapolyomavirus macacae)
• Systemic Immune Dyshomeostasis Model and Pathways in Alzheimer’s Disease (2019, Panax ginseng,Curcuma longa,Allium sativum,Ginkgo biloba,Pisum sativum,Zingiber officinale,Tripterygium wilfordii,Withania somnifera,Glycyrrhiza glabra,Centella asiatica,Berberis vulgaris,Human immunodeficiency virus 1,Human alphaherpesvirus 1,West Nile virus,Mus musculus,Rattus norvegicus,Clinitrachus argentatus,Auchenoglanis occidentalis,Homo sapiens,gut metagenome)
• High-Throughput Assessment of Kinome-wide Activation States (2019, Saccharomyces cerevisiae,Milicia excelsa,Homo sapiens,Mus musculus)
• Gut microbiota from colorectal cancer patients enhanced the progression of intestinal adenoma in Apcmin/+ mice (2019, NA)
• ‘Stemness’ maintenance pathways in CSCs (2019, NA)
• Proposed mechanisms in SS MSG (2019, NA)
• Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3B/Beta-catenin signaling pathway (2019, NA)
• Integrative regulation of physiology by histone deacetylase 3 (2019, NA)
• SPARCL1 promotes C2C12 cell differentiation via BMP7-mediated BMP/TGFB cell signaling pathway (2019, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Armoracia rusticana)
• Signaling pathway model of leptin in EA.hy926 endothelial cells (2019, NA)
• ER stress and chemo-resistance: Role of protein kinase R-like endoplasmic reticulum kinase (PERK) (2019, NA)
• mTORC1 and its signaling networks (2019, NA)
• Integrative regulation of physiology by histone deacetylase 3 (2019, NA)
• GREM1 expression is associated with genes involved in collagen formation and extracellular matrix (ECM) organization (2019, Homo sapiens,Mus musculus,Danio rerio)
• Signaling pathways that regulate autophagy and autophagy-related proteins that are affected by astaxanthin (AST) (2019, Saccharomyces cerevisiae,Nicotiana tabacum,Ganoderma lucidum,Haematococcus lacustris,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Drosophila melanogaster,Channa argus)
• Continuous impaired insulin signalling causes the activation of AD markers (GSK3B and TAU genes), thus increasing the amyloid beta aggregations leading to AD (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Proposed effects of ZnO nanocomposites on antigen-presenting cells and their potential role in inducing T cell responses in draining lymph node (2019, NA)
• Simplified diagram of estrogen signaling pathways, including genomic (canonical) and nongenomic (non-canonical) pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Equus caballus)
• Inflammatory signaling pathway and the resulting downstream responses (2019, NA)
• Targeting PKCι-PAK1 in EGFR-mutation positive non-small cell lung cancer (2019, Homo sapiens)
• Illustration of most of the proposed modes of action of antitumoral POMs (2019, Dipturus trachyderma,Triportheus paranensis,Clinitrachus argentatus,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Diaporthe sclerotioides,H3N2 subtype)
• Calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation (2019, Influenza A virus,unidentified influenza virus,Vesicular stomatitis virus,West Nile virus,Non-A non-B hepatitis virus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Oryza sativa,Triticum aestivum,Komagataella pastoris,Homo sapiens,Mus musculus,Pseudomonas aeruginosa,NA)
• lncRNA target pathway network analysis (2019, NA)
• Strategies for targeting the NKG2D/NKG2DL axis for cancer immunotherapy (2019, Homo sapiens)
• NKG2D/NKG2DL interaction activates NK cells (2019, Homo sapiens)
• Mechanism of HER2 targeted drugs and EGFR family in breast cancer (2019, NA)
• Mouse models used to study the PI3K/AKT/mTOR axis in PCa (2019, NA)
• Endoplasmic reticulum stress (ERS)-mediated apoptosis and cancer therapy (2019, NA)
• The most common signaling pathways influenced by probiotic strains employed in C (2019, NA)
• MTX affects several signal transduction pathways implicated in the pathogenesis of rheumatoid arthritis (RA) (2019, Human immunodeficiency virus,Chikungunya virus,Human parvovirus B19,Ross River virus,Mus musculus,Rattus norvegicus,Homo sapiens,Pneumocystis carinii,NA)
• Integrative regulation of physiology by histone deacetylase 3 (2019, NA)
• Working model of FH physiopathology and the effects of CoQ (2019, Homo sapiens)
• Non-genomic actions of thyroid hormone (2019, NA)
• Simplified overview of the signaling pathways in the target cells presented in this review that are relevant for the development of a pharmacological therapy rationale (2019, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Drosophila sp. in flies,Homo sapiens,Human immunodeficiency virus 1,Olea europaea,NA)
• ST2/IL-33 immune cells signaling pathway (2019, Homo sapiens,Mus musculus,Gallus gallus,Vicia sativa)
• Integrative regulation of physiology by histone deacetylase 3 (2019, NA)
• NK cell features in chronic HBV infection (2019, NA)
• Possible mechanisms of ERBeta-induced autophagy in tumor cells (2019, NA)
• Possible mechanisms of ERBeta-induced apoptosis in tumor cells (2019, NA)
• Social rank on blood cell gene expression and regulation vary by species and treatment according to two new studies in PNAS (, ) (2019, NA)
• Gene expression levels of central carbon metabolic pathways (2019, NA)
• Mechanisms involved in activation and regulation of NLRP3 canonical pathway (2019, NA)
• Nicotine-mediated signaling pathway with the stimulation of (A7)5 nicotine acetylcholine receptor (nAchR) and (A4)2(B2)3 nAchR (2019, NA)
• Aristolochic acid-induced cancer behavior in SV-HUC-1 cells (2019, NA)
• MRNA-miRNA interactions associated with the vascular endothelial growth factor (VEGF) signaling pathway (2019, Homo sapiens)
• Schematic view of sex determination (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Wnt/Beta-catenin signal transduction pathway in homeostasis (2019, Homo sapiens,Mus musculus,Drosophila melanogaster)
• DON toxicity to bovine renal epithelial cells (2019, NA)
• Scheme of chorismate synthesis from aromatic amino acids (tyrosine and phenylalanine) or the shikimate pathway (2019, Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Trypanosoma brucei,Leishmania major,Leishmania donovani,Plasmodium berghei,Entamoeba histolytica,Giardia intestinalis,Cryptosporidium parvum,Leishmania mexicana,Leishmania amazonensis,Trichomonas vaginalis,Ascaris suum,Acanthamoeba castellanii,Amoebozoa,Alveolata,Plasmodium knowlesi,Leishmania tropica,Eimeria tenella,Tritrichomonas suis,Euglenozoa,Plasmodium gallinaceum,Toxoplasma gondii RH,Endotrypanum monterogeii,Plasmodium cynomolgi,Plasmodium lophurae,Balantioides coli,Escherichia coli,Mycobacterium tuberculosis,Synechocystis sp. PCC 6803,Synechocystis sp.,Synechococcus elongatus PCC 6301,Rhodospirillum rubrum,Thermoplasma acidophilum,Chlorobaculum tepidum,Pseudomonadota,Chlorobiota,Wolinella succinogenes,Myxococcus fulvus,Campylobacter gracilis,Saccharomyces cerevisiae,Arabidopsis thaliana,Glycine max,Embryophyta,PX clade,Spinacia oleracea,Chlorophyta,Euglena gracilis,Lithospermum erythrorhizon,Pneumocystis carinii,Gallus gallus,Calloselasma rhodostoma,Homo sapiens,Mus musculus)
• Intracellular molecular alterations and their effects on tumour microenvironment immune activity (2019, Canis lupus familiaris,Equus caballus,Homo sapiens,Danio rerio)
• RTK and nRTK networks in H (2019, Helicobacter pylori,Homo sapiens)
• Metabolic interplay between various ROS generators (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Reactive oxygen species (ROS) metabolism (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Continuation of the processes described in A (2019, Mus musculus,Rattus norvegicus,Escherichia coli,Helicobacter pylori,Homo sapiens,Bos taurus)
• Hypothesized interactions between Smoothened and the CB1 receptor in the embryo (2019, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Matthiola incana,Cannabis sativa,Homo sapiens,Drosophila melanogaster,Leptospira kmetyi)
• Hypothetical model to depict the role of Trpc1 channels in linking the inhibition of BMP pathway by noggin, and the activation of Cav1.2 channels in ectodermal cells (2019, Gallus gallus,Danio rerio,Xenopus laevis,Ciona intestinalis,Ruditapes philippinarum,Mus musculus,Homo sapiens)
• Schematic summary of the responses on energy metabolic pathway reprogramming by genotoxic or non-genotoxic hepatocarcinogens in rat liver cells (2019, NA)
• Multiple immunosuppressive mechanisms coexist in tumor microenvironment (2019, NA)
• Hypothetic model of signaling pathways involved in the differentiation of hiPSC-CM from mesodermal progenitors (2019, NA)
• Discovery of metabolic pathway identified in both optimal cutting temperature-embedded and formalin-fixed paraffin-embedded samples (2019, NA)
• Putative palmitoylated proteins of the mechanistic target of rapamycin (mTOR) signaling pathway (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Gallus gallus,Coregonus peled,Homo sapiens,Raphanus sativus)
• Intracellular NAD metabolism (2019, Mus musculus,Rattus norvegicus,Escherichia coli,Cutibacterium acnes,Homo sapiens,Drosophila melanogaster,Homotherium serum)
• Main TLR-mediated signaling pathways triggered upon stimulation by LPS and LPG (2019, Escherichia coli,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Salmonella enterica,Klebsiella pneumoniae,Porphyromonas gingivalis,Cereibacter sphaeroides,Neisseria meningitidis,Francisella tularensis,Neisseria gonorrhoeae,Legionella pneumophila,Caulobacter vibrioides,Burkholderia pseudomallei,Coxiella burnetii,Mesorhizobium loti,Salmonella enterica subsp. enterica serovar Dublin,Bordetella bronchiseptica,Escherichia coli O9,Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Leishmania major,Dictyostelium discoideum,Leishmania donovani,Entamoeba histolytica,Leishmania mexicana,Leishmania infantum,Leishmania amazonensis,Trichomonas vaginalis,Leishmania braziliensis,Acanthamoeba castellanii,Leishmania tropica,Leishmania panamensis,Crithidia fasciculata,Leishmania aethiopica,Leishmania enriettii,Leishmania shawi,Mus musculus,Rattus norvegicus,Cavia porcellus,Canis lupus familiaris,Equus caballus,Homo sapiens,teleost fish,Lycium shawii)
• Diagram that illustrates the in situ flow of downregulated proteins (mark in green) in early development as a consequence of cAMP stimulation (2019, NA)
• Cell structure and function (2019, NA)
• Transcription regulators (TRs) that modulate glycolytic metabolism in cancer cells (2019, NA)
• Hypothetical scheme of the influence of ribosomal gene (RG) dosage in the genome of a non-carrier (green text and arrows) and a carrier (red text and arrows) of a monogenic autism mutation on the disease severity (2019, NA)
• Signaling pathways involved in Epithelial-to-Mesenchymal Transition (2019, NA)
• Functions of E-cadherin and N-cadherin (2019, NA)
• Graphical summary of perceived crosstalk of BMP2-mediated signaling and the NO pathway (2019, NA)
• Two faces of cGAS-STING signaling in cancer (2019, NA)
• Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma (2019, Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Caenorhabditis elegans,Shigella flexneri)
• Proteomic and Functional Analysis Reveals an Increased Chk1 Activity in Lung Cells that Contributes to Cisplatin Resistance(A) Identification of genes involved in differential cisplatin response (2019, NA)
• Summary of SP600125 enhances C-2-induced cell death in bladder cancer cells through resisting JNK- SQSTM1/p62- Nrf2 mediated anti-apoptotic pathway and switching autophagy to apoptosis (2019, Homo sapiens,Mus musculus)
• Hypothetical neuroimmune activation model leading to a vicious cycle of demyelination in metachromatic leukodystrophy (MLD) (2019, Lareunionomyces loeiensis,Allium cepa,Homo sapiens,Mus musculus,Canis lupus familiaris,Adeno-associated virus)
• Proposed model for coordinated epigenetics regulation of ER isotype (ERA and ERB) expression dynamics in breast cancer (2019, Ipomoea batatas,Momordica charantia,Homo sapiens)
• Schematic diagram depicting the MAPK/ELK1 signaling pathway linking Ang II-RBM20-titin splicing (2019, NA)
• Canonical Wnt ligands induce two mutually exclusive Dvl2- and Fyn-dependent arms (2019, Danio rerio,Xenopus laevis,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus,Homo sapiens)
• The role of MyoF during skeletal muscle development (2019, NA)
• Mitochondria-to-nuclear retrograde signaling pathways in mammals (2019, NA)
• Leptin-induced EMT via Src and FAK signaling pathways (2019, NA)
• MAPK signaling pathway: ERK1/2, JNK1/2, and p38 (2019, Drosophila melanogaster,Fasciola hepatica,Clonorchis sinensis,Opisthorchis viverrini,Opisthorchis felineus,Nicotiana tabacum,Commiphora wightii,Hydropuntia fisheri,Mus musculus,Rattus norvegicus,Gallus gallus,Molva molva,Homo sapiens)
• Network of the glutathione metabolism pathway (2019, Capsicum annuum)
• Summary of natural product regulation in proteostasis machinery (2019, Saccharomyces cerevisiae,Panax ginseng,Salvia miltiorrhiza,Glycyrrhiza uralensis,Polygonum cuspidatum,Mus musculus,Rattus norvegicus,Danio rerio,Opsanus beta,Homo sapiens,Drosophila melanogaster)
• LncRNAs regulate EMT signaling pathways (2019, Homo sapiens,Mus musculus)
• Components and regulatory factors in the complement alternative pathway (CAP) (2019, Homo sapiens)
• Non-autonomous regulation of ISC proliferation by enterocyte pyruvate metabolism (2019, Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Drosophila melanogaster)
• microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways (2019, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Mycobacterium tuberculosis H37Rv,Mycobacterium avium,Mycobacterium leprae,Mycobacterium marinum,Mycobacterium tuberculosis H37Ra,Mycobacterium avium subsp. hominissuis,Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways (2019, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Mycobacterium tuberculosis H37Rv,Mycobacterium avium,Mycobacterium leprae,Mycobacterium marinum,Mycobacterium tuberculosis H37Ra,Mycobacterium avium subsp. hominissuis,Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• Molecular pathway linked to oxidative stress response in E (2019, Echinococcus granulosus,Homo sapiens)
• Regulatory mechanism of the VEGF signal pathway in different groups (2019, Homo sapiens,Mus musculus,Ovis aries)
• Regulatory mechanism of the MAPK signal pathway in different groups (2019, Homo sapiens,Mus musculus,Ovis aries)
• Regulatory mechanism of the PI3K-AKT signal pathway in different groups (2019, Homo sapiens,Mus musculus,Ovis aries)
• Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol (2019, Escherichia coli,Ralstonia solanacearum,Homo sapiens)
• Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells (2019, NA)
• Protein kinase C pathway for prolactin regulation of metabolic gene expression in prostate epithelial cells as represented by mitochondrial aspartate aminotransferase (2019, Homo sapiens,Mus musculus,Vasconcellea candicans)
• TGF-beta signaling pathway annotated by ceRNA pairs of CDKN2B (p15) (2019, NA)
• DAMGO and morphine differentially assemble protein-interaction networks to control MOR spatiotemporal signaling (2019, NA)
• DNA-driven cGAS-cGAMP-STING signaling mediates innate immune response (2019, Streptococcus pyogenes,Serratia marcescens,Homo sapiens,Mus musculus,Drosophila melanogaster,Human T-cell leukemia virus type I)
• Role of HO as master regulator of cell physiology (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Sus scrofa)
• Targeted components of the MAPK and AKT signaling cascades by small-molecule inhibitors in cancer (2019, Mus musculus,Rattus norvegicus,Citrus trifoliata,Aesculus hippocastanum,Homo sapiens,Canis lupus familiaris)
• Mitogen-activated protein kinase (MAPK) inhibitor efficiency based on mutational status—cause of resistance and weak spots (2019, Mus musculus,Rattus norvegicus,Citrus trifoliata,Aesculus hippocastanum,Homo sapiens,Canis lupus familiaris)
• Parallel outline of several physiological roles of the TGFB/p38, mitogen-activated protein kinase (MAPK), and P13k/AKT/mTOR signaling pathways (2019, Mus musculus,Rattus norvegicus,Citrus trifoliata,Aesculus hippocastanum,Homo sapiens,Canis lupus familiaris)
• Effect of Ad-Cyp8b1 on liver and intestine gene expression and mTORC1 signaling in HFD-fed mice (2019, Homo sapiens,Mus musculus,Adenoviridae)
• Activation of CREM signaling pathway in spermatozoa of idiopathic infertile patients post-antioxidant treatment (2019, NA)
• After co-culture between adipocytes and breast cancer (BC) cells, high levels of miR-144 and miR-126 were released by exosomes by BC cells (2019, Homo sapiens,Mus musculus)
• Models of EGFR-ligand dependent pathway and EGFR-ligand independent pathway in EIS cells (2019, NA)
• Gene activities in the TGF beta signaling pathway (2019, Homo sapiens,Mus musculus,Staphylococcus aureus)
• Gene activities in the calcium signaling pathway (2019, Homo sapiens,Mus musculus,Staphylococcus aureus)
• Gene activities in the cytokine-cytokine receptor interaction pathway (2019, Homo sapiens,Mus musculus,Staphylococcus aureus)
• PTEN in cancer immune microenvironment regulation (2019, NA)
• Mechanism of resistance to arsenic trioxide- all-trans retinoic acid (ATO-ATRA) therapy in APL (2019, Homo sapiens,Mus musculus,Bos gaurus,Astrammina rara)
• Growth signal activates ATF4 and mitochondrial metabolism (2019, NA)
• Canonical Wnt signaling pathway (2019, Mus musculus,Homo sapiens)
• Crosstalk between RAS-ERK pathway and FOXM1 (2019, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Aspergillus flavus,Mus spretus,Homo sapiens,Caenorhabditis elegans,Salmonella enterica subsp. enterica serovar Typhimurium,Hepatitis B virus,NA)
• Different pathways regulation of hippo pathway (2019, NA)
• Prototypical oncogenes and tumor suppressor genes on major metabolic processes (2019, Homo sapiens,Mus musculus,NA)
• Complement and coagulation cascades signaling pathway and RT-qPCR verification (2019, NA)
• Transforming growth factor (TGF)B pathway in fibrotic liver which can lead to hepatocellular carcinoma (2019, NA)
• Strategies for therapeutic intervention of cancer involving FADD (2019, NA)
• Dynamic mechanisms of inter- and intratumor heterogeneity (2019, NA)
• Possible mechanisms of hyperglycemia-induced cellular oxidative damage in the fetal heart (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Gallus gallus,Sus scrofa)
• Notch signaling pathway by ubiqutination upon binding of Jagged/Delta (JAG/DLL) ligands to the Notch receptor (N1); the endocytic system is activated in the ligand-bearing cell (2019, NA)
• TGFB signaling pathway and its regulation by ubiqutination TGFB released from the LTBP1 complex binds to TGFB receptor II (TGFBRII) and initiates transphosphorylation and activation of the associated TGFB receptor I (TGFBRI) (2019, NA)
• Wnt signaling pathway and its regulation by ubiquitination The canonical Wnt signaling pathway is triggered by Wnt ligand binding to the complex of its receptor, Frizzled, and co-receptors LRP5/6 (2019, NA)
• Pathways controlling the epithelial-mesenchymal transition (EMT) program in prostate cancer (PC) (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,NA)
• Influence of high CO2 concentration on hormone and stomatal regulation (2019, Pinus massoniana,Homo sapiens)
• Proteomic workflow for the investigation of molecular determinants of acquired resistance to cetuximab (2019, Homo sapiens,Mus musculus,Escherichia coli,Agriosomyces longus)
• Cooperative gene regulation for mitochondrial quality control by Nrf2 and ATF4 (2019, NA)
• Different functions that As–RAD9 may be involved in (2019, NA)
• Network of pancreatic cancer-target genes (2019, herbal medicine,Curcuma wenyujin,Homo sapiens)
• Targeting LCSCs by suppression of autophagy and Nanog.Autophagy positively regulated LCSCs by suppressing p53 and favoring the activity of Nanog (2019, NA)
• Apoptotic signaling pathway (2019, Homo sapiens,Bos taurus,Lentzea albida)
• Network of Beta-elemene-target genes (2019, herbal medicine,Curcuma wenyujin,Homo sapiens)
• Putative genes and their expression patterns in the biosynthetic pathway of astaxanthin in H (2019, Saccharomyces cerevisiae,Embryophyta,PX clade,Cucumis sativus,Chlamydomonas reinhardtii,Haematococcus lacustris,Chromochloris zofingiensis,Vicia sativa,Monoraphidium neglectum,Vischeria stellata,Escherichia coli,Escherichia coli IS1,Homo sapiens,Bos taurus,Apostichopus japonicus)
• Pathway enrichment analysis of genes with eQTL associations with identified disease-associated SNPs (2019, NA)
• Mechanisms mediated through vitamin D (2019, NA)
• Mechanisms mediated through IGF-1/IGF-1R (2019, NA)
• ROS‐dependent priming and activation of the intrinsic cell death pathway (2019, NA)
• Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) as a central mediator of vascular aging (2019, Homo sapiens,Mus musculus,Sus scrofa,Parabacteroides chongii)
• ALDH1A1 regulation, potential retinoid signaling pathways, and functional effects of ALDH in CSCs (2019, NA)
• Executable network model as seen in the BMA tool (2019, NA)
• AKAP5 and AKAP12 in modulating oxidative stress in cardiac cells (2019, NA)
• The SGK3 signaling pathway (2019, NA)
• Signal PLC transduction pathway is coupled to PI re-synthesis to maintain the PIPn pool (2019, NA)
• Synthesis of phosphatidylinositol and acyl chain remodelling (2019, NA)
• Hypothetical schematic model for a novel oncogenic mechanism of G0S2 (2019, Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• Molecular interactions in Immunometabolism governing lipid metabolic disorders (2019, NA)
• Activated STAT3/5 signaling pathway by IL-6 receptor, Prolactin (PRL) receptor, VEGF Receptor, EGF Receptor, and IL-10 receptor (2019, NA)
• Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment (2019, NA)
• Possible mechanisms of actions of Rg1 in ER positive cells (2019, NA)
• Figure shows an MPR route that gets activated by the stimulation of progesterone receptor and has a role in cell proliferation by upregulation of PKA/cAMP by the activation of CREB/CREM/ATF-1 (2019, NA)
• Significant KEGG pathways enrichment of DEGs (2019, Homo sapiens,Mus musculus,prion,Human T-cell leukemia virus type I)
• HDAC6 inhibition repressed B cell signaling pathways in NZB/NZW mice (2019, Human immunodeficiency virus 1,Arachis hypogaea,DNA viruses,Leucanthemum maximum,Homo sapiens,Mus musculus,Escherichia coli,Equus caballus,NA)
• SHP-2 in cytokine receptor signaling (2019, Homo sapiens,Macaca fascicularis,Mus musculus,Drosophila melanogaster,Panthera pardus)
• SHP-2-mediated activation of ERK (2019, Homo sapiens,Macaca fascicularis,Mus musculus,Drosophila melanogaster,Panthera pardus)
• GPER signaling pathways in cancer cells (2019, NA)
• Docosahexaenoic acid (DHA) signaling pathway detected by GSEA (2019, Homo sapiens,Mus musculus)
• Schematic diagram showing role of Tbx15 on adipocyte browning and obesity (2019, NA)
• Complement system and therapeutic targets in bacterial meningitis (2019, NA)
• Inhibitory effects of butein on cell proliferation and TNF-Alpha-induced CCL2 release in racially different triple negative breast cancer cells (2019, NA)
• Ovarian cancer pathway enriched by target genes of the identified miRNA biomarkers in IPA (2019, Homo sapiens,Venustaconcha ellipsiformis)
• Model summarizing the ABeta-induced actin cytoskeletal abnormalities via SHIP2-PI(3,4)P2-ARAP3-RhoA signaling pathway (2019, NA)
• Supposed mechanism (2019, NA)
• Our proposed model of nsDNA-induced APOL1 expression through engagement of the cGAS/IFI16-STING pathway in human immortalized AB8/13 podocytes (2019, NA)
• Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways (2019, NA)
• Wnt signalling pathway uniquely identified by ce‐Subpathway (2019, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• miRNA-mediated control of Treg-cell development (2019, NA)
• Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways (2019, NA)
• Heme biosynthetic pathway and experimental porphyria models (2019, NA)
• Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways (2019, NA)
• Macrophage infection affects host metabolic state and can induce an M1 profile (2019, NA)
• Schematic model of JMJD2C promoted CRC metastasis by regulating the histone methylation level of the MALAT1 promoter and enhancing Beta-catenin signaling pathway (2019, NA)
• Necroptosis molecular pathway (2019, NA)
• Carcinogenesis and Reactive Oxygen Species Signaling: Interaction of the NADPH Oxidase NOX1–5 and Superoxide Dismutase 1–3 Signal Transduction Pathways (2019, NA)
• Cell signaling regulation of endogenous H2S in the central nervous system (2019, NA)
• VEGF (vascular endothelial growth factor)‐angiogenesis signaling and cell cycle regulation pathways (2019, NA)
• Functional consequences of VPAC receptors signaling (2019, NA)
• Orexins/OXR system-modulated signaling patways involved in anti-inflammatory, neuroprotective and anti-tumoral effects (2019, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,unidentified influenza virus,H1N1 subtype,Homo sapiens,Saccharomyces cerevisiae,Porzana carolina)
• AA-induced vasorelaxation and relationship to aldehyde metabolism (2019, NA)
• Optogenetic switches (2019, Saccharomyces cerevisiae,Homo sapiens)
• Schematic illustration the role of ES-EVs on MSCs (2019, Homo sapiens,Mus musculus,Bos taurus,Parthenos sylvia)
• Pathview analysis of the NFKB signaling pathway (2019, Fusobacterium nucleatum,Homo sapiens)
• Schematic mechanism of matrine signaling pathway that inhibits cell growth and leads to cell death in HL-7702 cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio,Porcine reproductive and respiratory syndrome virus,Sophora flavescens,NA)
• Probable mechanisms of the effects produced by lncRNAs on SCI (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• MI‐related subpathways where key nodes are annotated (2019, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• GSK3 regulates cell death, renewal, and differentiation (2019, NA)
• GSK3b and growth regulation (2019, NA)
• The principal signaling events occurring during fluid shear stress in bone cells (2019, NA)
• Three example models in the CODA-ML format (2019, NA)
• PI3K-Akt signaling pathway (2019, Bos taurus,Equus caballus,Camelus dromedarius,Bubalus bubalis,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• MicroRNAs and their regulatory networks in Chinese Gushi chicken abdominal adipose tissue during postnatal late development (2019, NA)
• MiRNA–mRNA interaction networks containing five cell proliferation and differentiation related pathways (2019, NA)
• Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development: A mathematical model (2019, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Human papillomavirus,Vesicular stomatitis virus,Homo sapiens,Lareunionomyces loeiensis)
• KEGG pathway enrichment analysis of methylated regions– (2019, Homo sapiens,Diaporthe sclerotioides)
• Proposed signaling pathway of the study (2019, Homo sapiens,Mus musculus,Oldenlandia diffusa)
• Non-genomic mechanisms of thyroid hormones action in the brain (2019, NA)
• Glycolysis pathway showing how increased PFK-2/FBPase-2 expression and phosphorylation, stimulates glycolysis via increased fructose-2,6-bisphosphate synthesis acting as a powerful allosteric activator of PFK-1 (2019, NA)
• We shall overcome (drug resistance) some day (2019, Homo sapiens,Eucalyptus intertexta)
• Engineered cardiac tissues (ECTs) generated in Biowire II platform have canonical responses to compounds that affect contractility via physiologically relevant pathways (2019, NA)
• Pathways enriched for each chemical (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Action of EC-7072 targeting the BCR signaling pathway in CLL cells (2019, Homo sapiens,Mus musculus,Streptomyces argillaceus)
• Proposed role of the immunogenic cell death in pemphigus foliaceus (2019, Homo sapiens,Mus musculus,Candida dubliniensis,Lavinia exilicauda)
• Signaling pathways (2019, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Canis lupus,Drosophila melanogaster,Caenorhabditis elegans,Thymallus thymallus,Fundulus heteroclitus,Taxila haquinus,Nothobranchius furzeri,Mus musculus,Rattus norvegicus,gut metagenome,human gut metagenome,Homo sapiens,Saccharomyces cerevisiae,transposons)
• Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions (2019, NA)
• Developmental processes regulate craniofacial variation in disease and evolution (2019, NA)
• Fluid forces shape the embryonic heart: insights from zebrafish (2019, NA)
• Hub genes and module analysis of the PPI networks (2019, Homo sapiens,Mus musculus,clinical samples,stable RNAs)
• Important metabolism-related cellular signaling cascades where FKBP51 was shown to play a decisive role (see main text for further details) (2019, NA)
• GCs affect cross-talk of bone cells and their communication with muscle, vasculature and myeloid cell-derived osteoclasts (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Oryzias latipes)
• Canonical and non-canonical Wnt signaling manipulation by pathogens occupying an extracellular niche (2019, NA)
• Canonical and non-canonical Wnt signaling manipulation during E (2019, NA)
• Canonical Wnt signaling manipulation during Rickettsia spp (2019, NA)
• Canonical Wnt signaling manipulation during bacterial infection of epithelial cells (2019, NA)
• Non-canonical/Beta-catenin-independent Wnt signaling pathways (2019, NA)
• Canonical/Beta-catenin-dependent Wnt signaling (2019, NA)
• Network structure of the 66 genes (left figure) and the top 12 selected genes listed in (right figure) from KEGG “Drug metabolism-cytochrome P450” pathway, extracted using the R package KEGGgraph (2019, NA)
• Protein-Protein interaction network of the 214 identified proteins: network nodes represent proteins, network edges indicate the strength of data support (STRING v10.5) (2019, Homo sapiens,Bos taurus,Sequoia sempervirens)
• Proposed model (2019, Homo sapiens,Mus musculus,Armoracia rusticana,NA)
• mTORC pathway regulation (2019, NA)
• Noise-induced bistability and resolution of fate dichotomies (2019, NA)
• Notch-induced autophagy and translational noise as destabilizers of cellular memory (2019, NA)
• Notch pathway amplifies intrinsic noise by interactions that improve the efficiency of global protein synthesis (2019, NA)
• Molecular mechanism of miR-129-5p regulation of ZIC2 expression and the Wnt/Beta-catenin signaling pathway in PCa (2019, Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana,Escherichia coli DH5alpha)
• Palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Hepatitis B virus)
• Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance (2019, NA)
• Major G protein-coupled receptor (GPCR) signaling pathways (2019, Drosophila melanogaster,Caenorhabditis elegans,Branchiostoma lanceolatum,Branchiostoma floridae,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens)
• Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation (2019, Solanum tuberosum,Agaricus bisporus,Hericium erinaceus,Mus musculus,Rattus norvegicus,Homo sapiens,Cyanea capillata)
• Mechanism of regulatory actions of E2 on MAP1A and hemoglobin A transcription (2019, NA)
• Biosynthesis, hydrolysis and metabolism of glucoraphanin (2019, Homo sapiens,Brassica oleracea)
• Bilobalide Suppresses Adipogenesis in 3T3-L1 Adipocytes via the AMPK Signaling Pathway (2019, Armoracia rusticana,Allium sativum,Ginkgo biloba,Punica granatum,Prunus domestica,Cichorium intybus,Trametes versicolor,Prunus salicina,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed biosynthetic pathway for compounds 1–8 (2019, NA)
• Immunometabolic changes associated with DC maturation (2019, NA)
• PVT1 participates in the downstream signaling pathway of c-Myc by regulating key molecules (2019, Human gammaherpesvirus 4,Human papillomavirus,Homo sapiens,Mus musculus,Nicotiana tabacum,NA)
• Signal transduction of GDF11 (2019, NA)
• Model illustrating metabolic processes (2019, Homo sapiens,Hepatitis B virus)
• Ras signaling pathway shown as an interacting network (2019, Homo sapiens)
• Metabolic pathway of linoleic and arachidonic acid (2019, NA)
• Ct central metabolism (2019, NA)
• Central carbon metabolism and catabolite control protein CcpA (2019, NA)
• Mechanistic network analysis predicted by Ingenuity Pathway Analysis (2019, NA)
• Biochemical pathway (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• Non-coding RNAs as integrators of the effects of age, genes, and environment on ovarian aging (2019, Homo sapiens,Mus musculus)
• Schematic map of the potential signaling pathway showing alleviation of neuronal apoptosis by NaB via DJ-1/Akt-related anti-oxidative stress pathway (2019, NA)
• Transcription factor regulatory effect network identified using Ingenuity Pathway Analysis (IPA) (2019, NA)
• Probable mechanisms through which royal jelly (RJ) and its components extend lifespan (2019, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Apis mellifera,Gryllus bimaculatus,Staphylococcus aureus,Paenibacillus larvae,Paenibacillus larvae subsp. larvae,Ignatzschineria larvae,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharum officinarum,Homo sapiens)
• JNK signaling pathway mediated drug resistance (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Naja nigricollis)
• Schematic diagram of the JNK signaling pathway promoting cell death in ovarian cancer (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Naja nigricollis)
• External aggressors increase ROS production in the skin, which induces downstream MAPK signaling pathways, leading to an activation of NFKB and AP-1 (2019, NA)
• Model structure consists of HIF-1A signaling, tumor signaling, and ATP depletion modules (2019, Homo sapiens)
• Anti-hypertrophic role of miR-133a is mediated by inhibition of Gq-protein and PKC pathways (2019, NA)
• Decorin in cancer, based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (http://www.genome.jp/kegg‐bin/show_pathway?hsa05205) (2019, Mus musculus,Rattus norvegicus,Homo sapiens)
• MiR-1 targets the calcineurin–NFAT signaling pathway; miR-1 plays a protective role in cardiac hypertrophy by decreasing the expression of NFAT (2019, NA)
• Endogenously derived chemerin mediates a tumor-suppressive effect through inhibition of Wnt/Beta-catenin signaling in adrenocortical carcinoma (2019, NA)
• Understanding the Role of Antiviral Cytokines and Chemokines on Neural Stem/Progenitor Cell Activity and Survival (2019, NA)
• Mitogen-activated protein kinase signaling pathway (2019, Lactarius deliciosus)
• Proposed model of PI3K activation in CM-RES clones (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Summary of data showing TGFB1 recruitment of miR-143 and miR-145 to RISC to destabilize CFTR mRNA and impair the corrector/potentiator-mediated rescue of F508del-CFTR (2019, Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus)
• AMPK signaling pathway following EPA treatment in skeletal muscle cells (2019, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• The most significant Ingenuity Pathway Analysis (IPA) network of differentially regulated proteins in the MHO group compared to those from the MUHO group (2019, NA)
• JAK1-TYK2 heterodimer signaling pathway (2019, NA)
• Pathway signaling network generated from the genes located within the top 100 most differentially methylated CpG islands (2019, NA)
• An overview of myocardial energy substrate utilization (2019, NA)
• Mammalian O-mannosyl glycans: Biochemistry and glycopathology (2019, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Danio rerio,NA)
• Molecular mechanisms involved in the proliferative and cytokine response of hypoxic BMSCs (2019, NA)
• Schematics illustrating the possible neuroprotective mechanisms of BDNF in the hyperglycemia-induced neuroinflammation (2019, Mus musculus,Rattus norvegicus,Marmota monax,Adeno-associated virus,adeno-associated virus 2,Homo sapiens,Bos taurus,Gallus gallus)
• The pathway leading to IL-1B release from NK92 and its inhibition by DMF or MMF (2019, Homo sapiens,Mus musculus,Helicobacter pylori)
• TGFB receptors activate Smad signaling and non-Smad signal transduction pathways (2019, Drosophila melanogaster,Caenorhabditis elegans,Trichoplax adhaerens,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,other sequences)
• Hedgehog signaling and Wnt signaling in the primary cilium (2019, Homo sapiens,Mus musculus,Danio rerio,Canis lupus familiaris)
• Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion (2019, NA)
• Potential mechanisms of fluoxetine in the remission of AD (2019, NA)
• Autophagy pathway (2019, NA)
• Signaling pathways contributing to mucus production (2019, Mus musculus,Rattus norvegicus,unidentified influenza virus,Enterovirus,Homo sapiens,Helicobacter pylori,Hyssopus cuspidatus)
• Ca2+signaling pathway and the roles of CD38, Ca2+ channels, and G-protein-coupled receptors (2019, Mus musculus,Rattus norvegicus,unidentified influenza virus,Enterovirus,Homo sapiens,Helicobacter pylori,Hyssopus cuspidatus)
• Fas-FasL pathway and its roles in cell death and cell survival (2019, Mus musculus,Rattus norvegicus,unidentified influenza virus,Enterovirus,Homo sapiens,Helicobacter pylori,Hyssopus cuspidatus)
• CAMP signaling pathway and its relationships with B2-AR, GPCR, and potassium channels (2019, Mus musculus,Rattus norvegicus,unidentified influenza virus,Enterovirus,Homo sapiens,Helicobacter pylori,Hyssopus cuspidatus)
• Molecular mechanism of ZNF326-mediated regulation of Wnt signalling (2019, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Escherichia coli BL21)
• Functions of PGs and their subtypes (2019, Mus musculus,Rattus norvegicus,unidentified influenza virus,Enterovirus,Homo sapiens,Helicobacter pylori,Hyssopus cuspidatus)
• Additional gut microbial metabolites regulate host immunity and metabolism (2019, NA)
• Oncogenic KRAS effector pathways (2019, Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• BMME in myeloma bone disease (2019, NA)
• Cell Therapeutic Strategies for Spinal Cord Injury (2019, NA)
• Signalling induced by adhesion molecules inside the host cell (2019, NA)
• COPD creates a favourable microenvironment for lung cancer initiation and progression (2019, Respiratory syncytial virus,Enterovirus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• TSHR mediated signaling induced OF proliferation through Akt signaling and induction of miR-146a and miR-155 (2019, NA)
• Schematic presentation of Nipah virus (NiV)-induced modulation of type I interferon (IFN-I) production and signaling (2019, Adenoviridae,Adeno-associated virus,Vesicular stomatitis virus,Zika virus,Ebola virus,Cedar virus,Sus scrofa,Equus caballus,Felis catus,Mustela putorius furo,Pteropodidae,Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens,Chlorocebus aethiops,Saimiri,Phoenix dactylifera,NA,NA)
• RAS pathway shapes interactions between cancer cells and the immune microenvironment (2019, NA)
• RAS pathway in cancer (2019, NA)
• Proposed signaling pathway for how Piperlongumine (PL) reverses the resistance of cisplatin in NSCLC (2019, Homo sapiens,Mus musculus)
• Proposed bi-phasic model for the role of Egr-1 in activation of DCs and down-modulation of DC maturation upon challenge with T (2019, NA)
• Receptor composition of IL-12 family members and related cytokines (2019, NA)
• KEGG pathway map for MAPK signaling for flowering Chinese cabbage libraries (2019, NA)
• NLRX1 regulates immune system signaling (2019, NA)
• Platelet‐derived growth factors from breast cancer or neuroblastoma stimulate the platelet‐derived growth factor (PDGF) receptors and initiate immune and tumorigenesis response (2019, NA)
• Siglec-7 mediated inhibition of NK cell cytotoxicity towards tumor cells (2019, NA)
• FGFR pathway and dysregulation in cancer (2018, Homo sapiens)
• Predicted potential targets to combine with MAPK/ERK inhibition, using graph analytics (2018, Homo sapiens,Iris germanica)
• NFKB pathway and the inhibitory effect of various alkyl nitrate N-Aryl Piperamide on NFKB translocation and COX-2 function (2018, NA)
• Brief description of the interaction of a CD4+ T cell with B cells (2018, NA)
• Signaling pathway regarding the cell cycle regulation in human bladder transitional carcinoma/BFTC-905 cells after stimulated by LSS (2018, NA)
• Metabolic pathways are fertile ground for therapeutic interventions in SLE (2018, NA)
• Innate immune mechanisms in SLE (2018, NA)
• Cell motility in cancer invasion and metastasis: insights from simple model organisms (2018, Drosophila melanogaster,Homo sapiens)
• Important factors involved in the pathogenicity of septic shock caused by LPS from gram-negative bacteria (2018, NA)
• PolyI:C enhances IgA production in the NALT via the TLR3-TICAM1 pathway (2018, NA)
• Crosstalk between different PRRs in antifungal immunity (2018, NA)
• Novel insights into the dectin-1 signaling pathway (2018, NA)
• Genes in the mitochondrial fatty acid oxidation (FAO) pathway that have been studied for links to T2DM (2018, NA)
• General mechanism of SYK activation and SYK-mediated signaling: a pathway demonstrating the involving of downsignaling associated with SYK activation (2018, NA)
• Schematic overview of the two most common pathways with genetic alterations in thyroid cancer—mitogen-activated protein kinase (MAPK) and phosphatidylinositide 3-kinase (PI3K) pathways (2018, NA)
• Protein pathway analysis using serum proteins present in healthy controls and/or AA patients (2018, Homo sapiens)
• Hepcidin regulation by iron and erythropoiesis (2018, Homo sapiens,Mus musculus,Xanthorhoe munitata)
• Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the glomeruli (2018, Homo sapiens,Mus musculus)
• Differentially expressed transcripts in FSGS were enriched in the JAK-STAT pathway in the tubulointerstitium (2018, Homo sapiens,Mus musculus)
• Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics (2018, NA)
• Estradiol and testosterone and the subsequent vascular response (2018, Homo sapiens)
• Inflammation and renal fibrosis: recent developments on key signaling molecules as potential therapeutic targets (2018, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified,Ganoderma lingzhi)
• Cholesterol-dependent inflammatory response and cell death in the hepatocyte (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Glycine max,Olea europaea,Homo sapiens,Oryctolagus cuniculus)
• Selectins in cancer immunity (2018, Homo sapiens,Mus musculus)
• Schematic overview of cytoplasmic 60S subunit assembly (2018, Escherichia coli,Archaeoglobus fulgidus,Plasmid pTF1,Escherichia coli PA2,Saccharomyces cerevisiae,Drosophila melanogaster,Danio rerio,Xenopus laevis,Triticum aestivum,Dictyostelium discoideum,Homo sapiens,Mus musculus,Bos taurus,NA)
• Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging (2018, NA)
• DUBs regulating TCR signaling (2018, NA)
• LMP-1 rescues Smads from Smurf1-mediated proteosomal degradation (2018, Homo sapiens,Bos taurus,Oryctolagus cuniculus,Macaca mulatta,Rattus norvegicus)
• Non-canonical functions of the RB protein in cancer (2018, NA)
• Non-canonical functions of the RB protein in cancer (2018, NA)
• CNT signaling in Mtb (2018, Mycobacterium tuberculosis)
• Metabolic pathways regulated during T cell differentiation (2018, NA)
• Metabolic reprogramming in CRC (2018, NA)
• Cross-talk between the CDK4/6 and mitogenic signaling pathways in cancer (2018, Mouse mammary tumor virus,Woolly monkey sarcoma virus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Impact of oncogenic pathways on evasion of antitumour immune responses (2018, Homo sapiens,Mus musculus,Hepatovirus A)
• Schematic diagram illustrating a role of PI3K, Rho and ROCK pathways in hypoxia-induced ATP release and ATP-mediated angiogenic effects in vasa vasorum endothelial cells (2018, NA)
• The TGFB superfamily in cardiac dysfunction (2018, NA)
• TGFB family members exhibit distinct effects on heart hypertrophy TGFB binds to its own receptors RII and RI, activates TAK1, SMAD2/3, and p38, and moderately promotes cardiac hypertrophy (2018, NA)
• Leptin binds to the LEPR and mediates multiple downstream pathways (2018, NA)
• Pathways that may impact radiosensitivity (2018, Homo sapiens)
• Hippo pathway (2018, Homo sapiens,Major minor)
• Schematic diagram representing possible antifungal mechanism (a–e) of CIN and EUG in C (2018, Saccharomyces cerevisiae,Diaporthe sclerotioides,Candida dubliniensis,PX clade,Candida albicans,Cinnamomum verum,Nakaseomyces glabratus,Syzygium aromaticum,Candida tropicalis,Candida parapsilosis,Penicillium expansum,Carex albicans var. albicans,Trichophyton rubrum,Wickerhamomyces anomalus,Delisea pulchra,Candida haemuloni,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhi,Homo sapiens,Mus musculus,Bos taurus)
• Type I interferon in rheumatic diseases (2018, NA)
• Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing (2018, NA)
• Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing (2018, NA)
• WNT signaling and regionalization of the GI tract epithelium (2018, NA)
• PI3K/Akt pathway plays a central role in nutrient-mediated cell proliferation and growth (2018, Drosophila melanogaster,Homo sapiens)
• Endothelial dysfunction and angiogenesis impairment in the ageing vasculature (2018, NA)
• Outside-in and inside-out signal transduction in myofibroblastic activation (2018, NA)
• Altered Metabolic Pathways in Glioblastoma (2018, NA)
• Synthetic Biology Tools for Programming Cell and Tissue (2018, NA)
• Possible sex effects on aspects of the CR/Met R mechanistic pathways (2018, NA)
• Metabolic drugs and molecular pathways exploitable to drive microglia into a pro‐regenerative phenotype (2018, NA)
• Receptors and signaling pathways mainly contributing to anti‐inflammatory polarization of microglia (2018, NA)
• Schematics of cellular energy-generating pathways (2018, NA)
• Cancer-selective strategy to target the NFKB signalling pathway (2018, NA)
• Type I IFN plays an integral role in macrophage regulation of Mmp28 following stimulation with PAMP (2018, NA)
• Progress in the Management of Malignant Pleural Mesothelioma in 2017 (2018, Human alphaherpesvirus 1,Vaccinia virus,Measles morbillivirus,Homo sapiens,Mus musculus,NA)
• Molecular cloning of flavonoid biosynthetic genes and biochemical characterization of anthocyanin O-methyltransferase of Nemophila menziesii Hook. and Arn (2018, NA)
• Cellular mechanisms and signals that coordinate plasma membrane repair (2018, NA)
• Menin-associated pathways with potential targeted therapies (2018, Mus musculus,Rattus norvegicus,Adeno-associated virus,Betapolyomavirus macacae,Homo sapiens)
• Soluble amylin and pramlintide are capable of activating the endogenous AMYR which is responsible for recruiting adenylate cyclase (2018, Mus musculus,Rattus norvegicus,Homo sapiens,prion)
• Examples of axonal stress that lead to activation of DLK (2018, NA)
• Calcium-sensing receptor in physiology and in calcitropic and non-calcitropic diseases (2018, NA)
• Systemic Inflammation in Cancer-Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Adiponectin-mediated signaling pathway in HSCs (2018, Olea europaea,Matthiola incana,Raphanus sativus,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Escherichia coli)
• Non-canonical Hippo signaling in the regulation of leukocyte function (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Non-canonical Hippo signaling in the regulation of leukocyte function (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Network of Neurotrophin signaling pathway (2018, NA)
• Sepsis-Induced Thrombus Formation and Cell-Specific HIFs (2018, Homo sapiens,Mus musculus,Bos taurus)
• Proposed Shh-Foxd1-Cdkn1c signaling model (2018, NA)
• Ontology-Driven Representation of Fanconi Anemia and Acquired Aplastic Anemia (2018, Homo sapiens,Mus musculus,unidentified,Lavandula angustifolia,Anisakis simplex)
• Optogenetic control of phosphatidylinositol signaling (2018, NA)
• Receptor tyrosine kinase (RTK) signaling was subjected to BL-dependent optogenetic control as exemplarily illustrated for the MAPK/ERK pathway (2018, NA)
• Schema of multiple pathway targets in CRC described in the review (2018, NA)
• Biosynthesis of O-GlcNAc and UDP-GlcNAc (2018, NA)
• Mechanisms Linking Mechanotransduction and Cell Metabolism (2018, NA)
• Polyamine metabolism and cancer: treatments, challenges and opportunities (2018, NA)
• Polyamine metabolism and cancer: treatments, challenges and opportunities (2018, NA)
• Schematic summarizing the “reprogramming” of polyamine metabolism by iron-depletion in: (A) SK-Mel-28 human melanoma and (B) MCF-7 human breast cancer cells (2018, Saccharomyces cerevisiae,Armoracia rusticana,Schizosaccharomyces pombe,Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Escherichia coli PA5,Homo sapiens,Gallus gallus)
• Polyamine metabolic pathway (2018, Saccharomyces cerevisiae,Armoracia rusticana,Schizosaccharomyces pombe,Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Escherichia coli PA5,Homo sapiens,Gallus gallus)
• Concerted GluR Signaling at the Synapse (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Molecular regulation of PFGA in Mice (2018, Bos taurus,Equus caballus,Camelus bactrianus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Using Systems Biology and Mathematical Modeling Approaches in the Discovery of Therapeutic Targets for Spinal Muscular Atrophy (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio)
• Ca2+signaling in T (2018, NA)
• Signaling downstream of the IL-2 receptor (IL-2R): (a) Janus kinase-signal transducer and activator of transcription (JAK-STAT) signal transduction (2018, Homo sapiens,Mus musculus,Prunus persica)
• Proposed scheme for PAHSA synthesis (2018, NA)
• DNA repair pathways—a toolkit for viral replication (2018, NA)
• Interactive signaling pathway of EGFR-PI3K-mTOR (2018, Homo sapiens,Mus musculus,Nicotiana tabacum,Human papillomavirus,Streptomyces hygroscopicus)
• Signaling Cascades leading to contraction in lymphatics (2018, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Felis catus,Staphylococcus aureus,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Porphyromonas gingivalis,Mycobacterium tuberculosis variant bovis,Mycoplasmopsis pulmonis,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Cavia porcellus,Turdus migratorius,Homo sapiens,Drosophila melanogaster,Macaca mulatta,Wuchereria bancrofti,Armoracia rusticana,Human immunodeficiency virus 1)
• Galantamine-memantine combination superior to donepezil-memantine combination in Alzheimer’s disease: critical dissection with an emphasis on kynurenic acid and mismatch negativity (2018, NA)
• IMMUNOINHIBITORY PD-1/PD-L1 PATHWAY IN INFLAMMATORY BLOOD VESSEL DISEASE (2018, NA)
• Schematic model in which HMW FGF2-mediated FGF23 stimulation of chondrocyte differentiation and OA is partially through modulation of the Wnt/Beta-catenin pathway (2018, NA)
• Ciliary signaling systems within tumors (2018, NA)
• DNA sensors and related signaling pathway (2018, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Human T-cell leukemia virus type I,DNA viruses,Betapolyomavirus macacae,Human alphaherpesvirus 2,Human alphaherpesvirus 3,Polyomavirus sp.,Human immunodeficiency virus 2,Variola virus,Merkel cell polyomavirus,Murid gammaherpesvirus 4,Modified Vaccinia Ankara virus,Myxoma virus,Murid herpesvirus 68,Ross River virus,Homo sapiens,Mus musculus,Gallus gallus,synthetic RNA,NA,NA)
• Dendritic structural plasticity and neuropsychiatric disease (2018, Mus musculus,Rattus norvegicus,Agaricus bisporus,Phleum pratense,Homo sapiens)
• Dendritic structural plasticity and neuropsychiatric disease (2018, Homo sapiens)
• JNK pathways in mammals and drosophila (2018, NA)
• One-carbon metabolism (2018, Oryza sativa,Triticum aestivum,Malus domestica,Oryza sativa Japonica Group,Jasminum officinale,Phragmites australis,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,Anthonomus grandis)
• Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of ClockΔ19 mutant mice (2018, Homo sapiens,Mus musculus)
• Thiamine and selected thiamine antivitamins — biological activity and methods of synthesis (2018, Bos taurus,Canis lupus familiaris,Capra hircus,Felis catus,Bison bonasus,Saccharomyces cerevisiae,Escherichia coli,Oryza sativa,Mycobacterium tuberculosis,Candida albicans,Borreliella burgdorferi,Zymomonas mobilis,Malassezia pachydermatis,Mus musculus,Rattus norvegicus,Gallus gallus,Triportheus paranensis,Homo sapiens,Caenorhabditis elegans,H5N1 subtype)
• Osteopontin (OPN) stimulated monocyte chemoattractant protein 1 (MCP-1) production and migration of monocytes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli,Armoracia rusticana)
• Proteins that Are Rhythmic in the Pentose-Phosphate Pathway Peak in Anti-phase to Those in Glycolysis (2018, Saccharomyces cerevisiae,Neurospora crassa,Aklioshbomyces papillarum,Neurospora crassa OR74A,Escherichia coli DH5alpha,Cereibacter sphaeroides 2.4.1,Homo sapiens,Mus musculus,Autographa gamma)
• Convergence of three vesicular pathways of endocytic traffic on the cross-presentation compartment in dendritic cells (2018, NA)
• Different subcellular sources of MHC-I molecules for cross-presentation (2018, NA)
• Probing dynamic signal transduction and filtering in cancer cells (2018, NA)
• EMT is Modulated by Multiple Cascades Through Several Networks (2018, NA)
• p38gamma MAPK-promoted EMT (2018, Homo sapiens,Armoracia rusticana)
• Translational control mechanisms (2018, NA)
• cGMP-mediated modulation of IOP through increase in AqH outflow (2018, NA)
• NO-GC-1-cGMP pathway (2018, NA)
• Expanded cholesterol synthesis pathway diagram (2018, Saccharomyces cerevisiae,Oryza sativa,Zea mays,Candida albicans,Candida albicans 24C,Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss (2018, NA)
• Lysosomes Mediate Benefits of Intermittent Fasting in Cardiometabolic Disease: The Janitor is the Undercover Boss (2018, NA)
• G-protein mediated effects on smooth muscle tone regulation (2018, NA)
• Proposed bioflocculant (BF) synthetic pathway and the genes of Citrobacter freundii IFO 13545 involved in the pathway (2018, NA)
• T cell activation induces cell surface expression of GLUT1 and amino acid transporters, facilitating uptake of glucose and glutamine (2018, Homo sapiens,Mus musculus,Candidatus Arthromitus sp. SFB-mouse)
• Assembling a protective shield (2018, NA)
• Statins and prenylation inhibitors in Marfan syndrome aneurysm development: hypothesized model (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• The HMG‐CoA (3‐hydroxy‐3‐methylglutaryl coenzyme A) reductase pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Metabolic Reprogramming in Colon Cancer (2018, Homo sapiens,vectors,Psidium guajava,Pollachius pollachius,Bifidobacterium aemilianum)
• IBD pathway, red nodes indicate genes differentially expressed in AUC or EUC (2018, NA)
• The genes and their functional relationships within the RLR signaling pathway (2018, Influenza A virus,unidentified influenza virus,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza A virus H3N2,H5N8 subtype,H7N7 subtype,Gallus gallus,Anas platyrhynchos,Homo sapiens,Mus musculus,Mustela putorius furo)
• Simplified illustration of TXNIP role in presumptive pathways involved in endothelial dysfunction (2018, Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Sus scrofa,Human immunodeficiency virus 1,Influenza A virus,Streptococcus sp. group B,Homo sapiens,Drosophila melanogaster)
• IPA network map depicting the DR signaling changes in HBEpCs after 6 h of infection with IAV H1N1 (2018, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,Sindbis virus,Reovirus sp.,H3N2 subtype,Influenza A virus H3N2,Influenza A virus AWSN1933H1N1,Feline calicivirus,Oryctolagus cuniculus,Canis lupus familiaris,Equus caballus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Ingenuity Pathway Analysis (IPA) network map depicting the DR signaling changes in HBEpCs after 2 h of infection with IAV H1N1 (2018, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,Sindbis virus,Reovirus sp.,H3N2 subtype,Influenza A virus H3N2,Influenza A virus AWSN1933H1N1,Feline calicivirus,Oryctolagus cuniculus,Canis lupus familiaris,Equus caballus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus)
• NFKB and IRF3 signaling pathway regulation by miRNAs implicated in inflammatory diseases (2018, NA)
• FOXO activity, stability, and localization are regulated by the insulin/IGF signaling pathway and reactive oxygen species (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Lareunionomyces loeiensis,Aphyosemion alpha)
• Signaling pathway activated by OxPAPC (2018, NA)
• Proposed model for the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1 signaling axis in HGF-mediated lamellipodia formation (2018, NA)
• Metabolites as regulators of insulin sensitivity and metabolism (2018, NA)
• Molecular signaling mechanisms of nicotine mediated anti-inflammatory effects (2018, NA)
• Compartmentalized Cyclic Nucleotides Have Opposing Effects on Regulation of Hypertrophic Phospholipase CE Signaling in Cardiac Myocytes (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Human epidermal growth factor receptor targeted inhibitors for the treatment of ovarian cancer (2018, NA)
• Protein synthesis and degradation pathways in skeletal muscle (2018, NA)
• Role of PAK signaling in response to inflammation, altered microbiota and hyperglycemia (2018, NA)
• Intercellular and intracellular signals that initiate liver regeneration (2018, NA)
• Lipids in Children and Links to Adult Vascular Disease (2018, Homo sapiens)
• Downstream effectors and upstream regulatory pathways of RKIP (2018, NA)
• Relationship between the overexpression of YY1 and autophagy (2018, Homo sapiens,Mus musculus)
• Relationship between the downregulation of PTEN and autophagy (2018, Homo sapiens,Mus musculus)
• Relationship between NFKB and autophagy (2018, Homo sapiens,Mus musculus)
• Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain (2018, NA)
• TRAIL pathway targeting therapeutics (2018, NA)
• Chaperone mediated autophagy mechanism (2018, NA)
• Oncogenic and tumor suppressive signaling involving Dmp1 and Arf (2018, NA)
• Schematic Representation of DDR1-collagen signaling pathway in cancer (2018, NA)
• Summary of interactions between ECM remodelling and kinase activity (2018, NA)
• Microbiota and the intestinal barrier against infectious threats (2018, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Vibrio cholerae,Clostridioides difficile,Shigella flexneri,Bacteroides fragilis,Campylobacter jejuni,Citrobacter rodentium,Clostridium perfringens,Escherichia coli O157H7,Faecalibacterium prausnitzii,Akkermansia muciniphila,Salmonella enterica subsp. enterica serovar Typhi,Bacillus thuringiensis,Bacteroides thetaiotaomicron,Clostridioides difficile CD3,Bifidobacterium bifidum,Escherichia coli Nissle 1917,Clostridioides difficile CD8,Listeria innocua,Clostridium scindens,Pediococcus acidilactici,Escherichia coli PA5,Blautia obeum,Pseudomonas sp. C,gut metagenome,human gut metagenome,Homo sapiens,Mus musculus)
• Selective autophagy as a potential therapeutic target for neurodegenerative disorders (2018, NA)
• Proposed pathway of RSK related genes (2018, NA)
• Pathway representation for dopamine metabolism (2018, NA)
• Receptor for advanced glycation endp ro ducts (RAGE) is akey pathway for inflammatory complication sinaging and chronic disease (2018, NA)
• The processes underlying the proposed hypothesis of the temperature and CO2 effects on isoprene synthesis (2018, NA)
• Signaling pathway and GO analyses were performed to identify the biological functions of the subsets of differentially expressed genes after BP5 treatment (2018, Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Avian leukosis virus)
• Hepatic gluconeogenesis is modulated by histone deacetylases (HDACs) (2018, NA)
• Schematic overview of major enzymes and metabolites involved in the regulation of gluconeogenesis (2018, NA)
• Hexosamine pathway (2018, NA)
• Schematic/proposed signaling model of role and regulation of claudins in a cell during invasive or metastatic stage (2018, NA)
• Signaling model in a cell during tumor formation (2018, NA)
• Implementation of metabolic engineering strategies in S (2018, NA)
• Summary of the oncogenic pathways genetically disrupted in the UM-SCC oral cavity cell line panel (2018, NA)
• Interconnection between LXRs and AR in prostate cell.Note (2018, NA)
• The signaling pathway implicated in VIDD development (2018, NA)
• Glial immune interactions (2018, NA)
• An example of a reaction in our model for hypothetical PathwayX, which contains hypothetical components Prt1 and Prt2 (2018, NA)
• B-cell receptor (BCR) signaling pathways important to the pathophysiology and treatment options for chronic lymphocytic leukemia (CLL) (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic figure for sildenafil-mediated apoptotic sensitization pathways (2018, NA)
• Mechanism of IL-22, IL-22receptor as well as IL-22BP and signaling pathway (2018, NA)
• Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018, NA)
• Tuberculosis and impaired IL-23-dependent IFNG immunity in humans homozygous for a common TYK2 missense variant (2018, Vesicular stomatitis virus,Saimiriine gammaherpesvirus 2,Macacine gammaherpesvirus 4,Mycobacterium tuberculosis,Candida albicans,Mycobacterium tuberculosis variant bovis BCG,Candida albicans 23R,Homo sapiens,Mus musculus,Meleagris gallopavo)
• Cyclosporin A attenuating morphine tolerance through inhibiting NO/ERK signaling pathway in human glioblastoma cell line: the involvement of calcineurin (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Equus caballus,Raphanus sativus,Nepeta menthoides,Homo sapiens,Pollachius pollachius)
• SNO profile of inflammation and immune responses network in Chagas disease (2018, NA)
• SNO profile of cell death network in Chagas disease (ChD) (2018, NA)
• Mechanisms of S6K1 inhibitors-induced feedback activation of the PI3K pathway and insulin receptor sensitization (2018, herbal medicine,Zingiber officinale,Solanum aethiopicum,Zingiberaceae,Mus musculus,Rattus norvegicus,Homo sapiens)
• Methionine sets up a hierarchical metabolic response leading to anabolism (2018, Saccharomyces cerevisiae,Armoracia rusticana,Diaporthe sclerotioides,Saccharomyces cerevisiae S288C,Saccharomyces cerevisiae BY4741,Terfezia morenoi,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Mechanisms for human cervical epithelial cells (HCEs)-mediated HIV suppression in macrophage (2018, NA)
• Summary of the mechanisms involved in the stimulation of brown adipogenesis, mitochondrial biogenesis and energy expenditure by some dietary molecules (2018, NA)
• Model showing the possible pathways of neuropeptide Y-induced neuroprotective effects in Alzheimer's disease (2018, NA)
• Molecular mechanisms of viral oncogenesis in humans (2018, NA)
• Network displaying key genes involved in apoptosis, DSB repair, Fanconi anemia pathway and homologous recombination (2018, NA)
• Therapeutic approaches in Alzheimer's disease: GSK3 Inactivation therapy: Neuroprotective compounds such as curcumin modulates PI3K/Akt/GSK3B pathway, leading to inactivation of tau hyperphosphorylation (2018, NA)
• Interplay between mTOR, AB and Tau in Alzheimer's disease (2018, NA)
• Epigenetic regulation at the RUNX3 AS-associated locus (2018, NA)
• Three main features (GSIS, beta cell mass and insulin action) and insulin secretion pathway in GK rat (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Ursus maritimus,Pontia occidentalis)
• Simplified representation of the complement system, divided into pattern recognition molecules (PRMs), pathway specific and common components as well as inhibitors (2018, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Porphyromonas gingivalis,Streptococcus pyogenes,Borreliella burgdorferi,Neisseria meningitidis,Serratia marcescens,Tannerella forsythia,Prevotella intermedia,Streptococcus sp.,Filifactor alocis,Mus musculus,Rattus norvegicus,Candida albicans,Gnathostomata,Leuciscus idus,Trichoderma pseudocandidum,Homo sapiens,Human papillomavirus,Eumetazoa)
• ANG II signaling in aging (2018, NA)
• Renal ion regulation in response to ANG II (2018, NA)
• ANG II induces cardiac hypertrophy by multiple means involving direct actions on cardiac myocytes (cm) or the release of paracrine factors from other cell types, such as endothelial cells and fibroblasts/myofibroblasts (2018, NA)
• ANG II signaling and vascular fibrosis (2018, NA)
• DEPTOR [Dishevelled, Egl-10, and Pleckstrin (DEP) domain-containing mTOR-interacting protein] as a tumor suppressor (2018, Homo sapiens)
• Mechanistic target of rapamycin (mTOR) signaling network (2018, Homo sapiens)
• Simplified signaling pathway for vasopressin-mediated sodium-chloride cotransporter (NCC) regulation in distal convoluted tubule (DCT) cells (2018, NA)
• Signaling network regulating sodium-potassium-chloride cotransporter (NKCC2) and Na/H exchanger (NHE3) in thick ascending limb (TAL) cells (2018, NA)
• Three mechanisms of pexophagy in mammalian cells (2018, NA)
• Retinal phosphoproteome (2018, NA)
• Activating MAPK Pathway Mutations in LCH (2018, Homo sapiens,Mus musculus,Osphranter robustus)
• Signaling pathways activated after binding of E2 and G1 to GPER (2018, NA)
• Cell-intrinsic PD-L1 in modulating signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Emmelichthys struhsakeri)
• IL-6 signaling in the tumor cell of the bone marrow niche (2018, NA)
• Interferon (IFN)-dependent IFN stimulated gene (ISG) transcription through the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling (2018, NA)
• Effects of different stent techniques on angiogenesis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Gallus gallus)
• Role of Nrf2 in NAFLD (2018, NA)
• CTRP1 expression increases in response to glucocorticoids under dehydration conditions in skeletal muscle (2018, NA)
• DSBR pathways and the effect of RAD51 paralog loss on pathway choice (2018, NA)
• Cartoon depiction illustrating potential saturated free-fatty acid mechanisms that may underlie arrhythmogenic events (2018, Homo sapiens)
• Cardiac and macrophage inflammatory pathways (2018, Homo sapiens)
• Rapamycin inhibits the de-differentiation of vascular smooth muscle cells (2018, Oryctolagus cuniculus,Sus scrofa,Candida dubliniensis,herbal medicine,Homo sapiens,Mus musculus,Streptomyces hygroscopicus)
• Cellular functions and mechanisms of rapamycin (2018, Oryctolagus cuniculus,Sus scrofa,Candida dubliniensis,herbal medicine,Homo sapiens,Mus musculus,Streptomyces hygroscopicus)
• Sortilin and SorLA regulate IL-6 family signaling (2018, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Homo sapiens,Mus musculus,Sus scrofa)
• Regulation of GSK-3B activity (2018, NA)
• Role of Wnt signaling in osteoblasts (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Lareunionomyces loeiensis)
• Wnt signaling cascades (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Lareunionomyces loeiensis)
• Neisseria gonorrhoeae host-adaptation and pathogenesis (2018, Neisseria gonorrhoeae,Homo sapiens)
• Role Of Atm In Ebv Life Cycle Regulation (A) The central role of ATM in the replication compartment of EBV (2018, Human gammaherpesvirus 4,Human gammaherpesvirus 8,Human alphaherpesvirus 3,Murid herpesvirus 68,Saimiriine gammaherpesvirus 2,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Mechanism of CHOP regulation in ER stress induced apoptosis (2018, Human immunodeficiency virus 1,West Nile virus,Japanese encephalitis virus,Coxsackievirus B3,Infectious bronchitis virus,Porcine circovirus 2,Escherichia coli,Mycobacterium tuberculosis,Helicobacter pylori,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• Epigenetic control of CD8+ T cell differentiation (2018, NA)
• Epigenetic control of CD8+ T cell differentiation (2018, NA)
• Schematic overview on a striatal medium spiny neuron synapse (2018, NA)
• Molecular pathways modulating lifespan via control of the translation machinery (2018, NA)
• Environmental enrichment largely prevented age-SNCA-dependent disturbances and activated topologically relevant genes in the SNCA interactome with respect to both disturbance modes (2018, NA)
• Immunological mechanisms responsible for radiation-induced abscopal effect (2018, Homo sapiens,Mus musculus)
• Role of MAIT cells in spondyloarthritis (SpA) (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Integrative Modeling of Cancer-Type-Specific Hippo Regulatory Networks (2018, NA)
• PI3K pathway activation and cell-cycle in tumor cells (2018, Homo sapiens)
• Overview schematic of the proposed relationship of inhalant organic dust exposures induction of bone loss (2018, NA)
• Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Canis lupus familiaris)
• Proposed mechanism for ASIC1a regulation of striatal synaptic remodeling and motor learning (2018, NA)
• Working model (2018, NA)
• Variety of factors control Tn cell survival and metabolic pathway engagement after T cell activation (2018, Homo sapiens,Mus musculus,Catopsilia pomona)
• Core metabolic pathways for T cell survival, activation, differentiation, and function (2018, Homo sapiens,Mus musculus,Catopsilia pomona)
• Different signaling pathways related to EGFR activation induced by CTGF/EGFR interaction (2018, NA)
• FGFR1/FGF21/BKlotho complex actions in the cardiomyocytes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Inhibitors to specific mechanical and metabolic pathways (2018, Homo sapiens,Chlorocebus aethiops,Rattus norvegicus)
• Transcriptomic analysis of axon guidance signaling pathways in liver fibrogenesis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Hippo signaling network and its biological functions (2018, NA)
• mRNA translation stress feedback to ribosome biogenesis and cell proliferation (2018, NA)
• Hypothesized mechanism of S5-induced death of human melanoma A375 cells (2018, Armoracia rusticana,Nicotiana tabacum,Solanum lycopersicum,Withania somnifera,Physalis peruviana,Physalis angulata,Physalis pubescens,Physalis longifolia,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Expression of Insulin/IGF signaling components is modulated by miRNAs (2018, NA)
• Scheme of the main steps for autophagy and their regulation by AMPK (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• The non-polyphenolic compounds’ major mechanisms of action on CRC cells (2018, NA)
• The polyphenols’ major mechanisms of action on colorectal cancer (CRC) cells (2018, NA)
• Cholesterol biosynthesis deficiency syndromes (2018, NA)
• Schematic depiction of the TGFB signaling pathway (2018, Homo sapiens,Mus musculus,Hepatitis B virus)
• Schematic overview of RAS and PI3K pathway and their interconnection (2018, Homo sapiens,Rattus norvegicus)
• Simplified representation showing the interplay between the major signaling cascades activated by tyrosine kinase receptors (RTKs) and TSH-Receptor (TSH-R) (2018, NA)
• HGF/c-MET signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Many molecules regulate apoptosis and Hippo-YAP signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• TNFA receptors, pathways and different types of signals—schematic diagram (2018, Mus musculus,Rattus norvegicus,Bos taurus,Elephas maximus,Homo sapiens,Helicobacter pylori)
• Wnt1/Beta-catenin signaling as a key player in glia–neuron cross-talk (2018, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Eucalyptus intertexta,Homo sapiens,Mouse mammary tumor virus)
• Wnt1/Beta-catenin signaling regulation of midbrain dopaminergic (mDAergic) neuron survival/death according to our published findings [,,,,,,,,] (2018, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Eucalyptus intertexta,Homo sapiens,Mouse mammary tumor virus)
• Canonical Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) pathway and non-canonical Wnt/Ca2+ and Wnt/planar cell polarity (PCP) pathways [,,,,,] (2018, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Eucalyptus intertexta,Homo sapiens,Mouse mammary tumor virus)
• Summary of the proposed mechanisms of maternal cognitive impairment associated with gestational diabetes mellitus (GDM) (2018, NA)
• S100A10 plays a key role in regulating pro-tumorigenic processes including proliferation, adhesion, motility, invasion, metastasis, and therapy resistance (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Citrus macrophylla)
• Regulatory network of MBP-1 (2018, Arabidopsis thaliana,Triticum aestivum,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Staphylococcus aureus,NA)
• Drosophila Jak/STAT signaling components and the corresponding human homologs and their protein families (2018, Homo sapiens,Drosophila melanogaster)
• Visualization of DEGs involved in the mitogen activated protein kinase (MAPK) signaling pathway (2018, Phytophthora parasitica)
• Status of proteins that participate in the autophagy pathway in glioblastoma (2018, NA)
• Suppressive effects of P (2018, NA)
• DR and DR mimetics improve gut epithelial function (2018, NA)
• Schematic depicting the proposed hypothesis that resistance exercise-induced adaptations may require the Hippo pathway effectors YAP and TAZ (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway (2018, NA)
• Dishevelled: a masterful conductor of complex Wnt signals (2018, NA)
• Proposed anti-apoptosis mechanism for UDCA cardioprotection against hypoxia (2018, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Oryctolagus cuniculus,Sorghum bicolor,Saccharomyces boulardii nom. inval.,Homo sapiens)
• Neuroprotective mechanism of action of xyloketal B in ischemic condition (2018, NA)
• KEGG pathway analysis of the cell cycle in GNP-treated cells (2018, Mus musculus,Rattus norvegicus,Bos taurus,Armoracia rusticana,Capra hircus,Schizosaccharomyces pombe,Homo sapiens)
• NCOA4-mediated ferritinophagy pathway is regulated by intracellular iron (2018, NA)
• SUMO cycle (2018, NA)
• Hedgehog pathway activation in cancer (2018, NA)
• Major mechanisms for hepcidin regulation (2018, NA)
• HSV-1 deregulates host miRNAs (2018, NA)
• Phosphorylation of DLP1 and their effects on mitochondrial morphology and mitochondrial and cellular functions in cardiomyocytes: (A) DLP1 phosphorylation at S616 and S637 and their potential upstream signaling under AR stimulation (2018, NA)
• Transient receptor potential (TRP) channels and itch signaling (2018, Allium sativum,Thymus vulgaris,Origanum vulgare,Syzygium aromaticum,Mus musculus,Rattus norvegicus,Cavia porcellus,Caenorhabditis elegans,Phytomonas oxycareni,Homo sapiens,Bos taurus)
• Graphic representation of the hepatic Hepc pathway in conditions of systemic iron increase (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Relationship between mechanical loading and sclerostin expression (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis)
• Links between Lipid and Iron Metabolic Pathways (2018, NA)
• Transforming growth factorB 1 (TGFB1) mediates a signaling pathway in tissue fibrosis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Parechinus angulosus,NA)
• Chemoresistance (2018, NA)
• Intestinal uptake of non-heme iron and its regulation (2018, NA)
• Regulation of the Hippo/YAP signaling pathway in malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) (2018, NA)
• Notch and Wnt signaling pathways (2018, Mouse mammary tumor virus,Moloney murine leukemia virus,Avian myelocytomatosis virus,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Galatella linosyris,Homo sapiens,Drosophila melanogaster)
• Intermediary thiol metabolism in renal proximal tubular cells (2018, Mus musculus,Rattus norvegicus,Human papillomavirus type 16,Betapolyomavirus macacae,Homo sapiens,Bos taurus,Vasconcellea candicans)
• Autophagy, Keap1 and p62 regulate Nrf2 in HCC (2018, NA)
• Pathway analysis graph of G1/S checkpoint (2018, NA)
• Proposed PD-1 & PD-L1/L2 intra-cellular signaling between T cells and/or macrophage/monocytes, among others (e.g (2018, Homo sapiens,Mus musculus,Helicobacter pylori,NA)
• Metabolic pathways controlling macrophage activation states (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Escherichia coli 27A,Homo sapiens,Mus musculus,Candida dubliniensis)
• Immunological pathways targeted by the main novel therapies for IBD (2018, Klebsiella pneumoniae,Clostridioides difficile,Citrobacter rodentium,Clostridioides difficile CD3,Clostridioides difficile CD34,Clostridioides difficile CD45,Clostridioides difficile CD127,Clostridioides difficile CD90,Hordeum vulgare,Commiphora myrrha,Artemisia absinthium,Mus musculus,Rattus norvegicus,Homo sapiens)
• Dynamic gene expression profiles of CIK cells involved in the cell cycle and the natural killer cell–mediated cytotoxicity pathway (2018, Armoracia rusticana,Cryptococcus neoformans,Homo sapiens,Mus musculus,Bos taurus)
• Main flowering time pathways acting in Arabidopsis thaliana: Photoperiod (orange and yellow), ambient temperature (red), age (green), gibberellins (brown), autonomous (sky blue), vernalization (light blue) (2018, NA)
• Gut Microbiota, Fusobacteria, and Colorectal Cancer (2018, Fusobacterium nucleatum,Homo sapiens)
• From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis (2018, NA)
• Result of newborn mouse lens epithelial cell (2018, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• Proposed scheme of nutmeg action in soleus muscle (2018, NA)
• Red arrowhead represents inhibition (2018, NA)
• Proposed model of LUBAC-mediated ubiquitination on cFLIP in the TNFA receptor signaling pathway (2018, NA)
• YAP signaling pathway (2018, Brucea javanica,Hydrangea febrifuga,Taraxacum formosanum,Holarrhena pubescens,Erythrophleum guineense,Homo sapiens,Mus musculus,Sus scrofa,Triportheus paranensis,Aliivibrio fischeri)
• Simplified model of the molecular pathways by which neratinib and valproate combine to kill cancer cells (2018, Homo sapiens,Mus musculus)
• Simplified model of the molecular pathways by which pazopanib and AR42 combine to kill cancer cells (2018, Homo sapiens,Mus musculus)
• Qualitative Biological Regulatory Network (BRN) of Hexosamine Biosynthetic Pathway (HBP) intersection with PI3K-mTOR-Myc signaling and P53-MDM2 signalling axis (2018, NA)
• Dissection of the apparent clearance (CL/F) formula to describe all possible influencing parameters (2018, Homo sapiens)
• Long (lncRNA) and short (miRNA) of it: TGFBeta-mediated Control of RNA-binding Proteins and non-coding RNAs (2018, Homo sapiens,Mus musculus,Danio rerio,Hepatitis B virus)
• Molecular pathways that play central roles in mounting an immune response (2018, Caenorhabditis elegans,Homo sapiens)
• KIBRA/Hippo pathway as a shunt of stressful input (2018, NA)
• Hippo Pathway and its canonical upstream regulators (2018, NA)
• General mechanism of the extracellular signal-regulated kinase (ERK) pathway and key downstream products important in cocaine addiction (2018, Mus musculus,Rattus norvegicus,Sus scrofa,Sus scrofa domesticus,Homo sapiens)
• Sagittal representation of the mesocorticolimbic system and the brain stress-related areas (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• FGF and VEGF signaling network (2018, Homo sapiens,Rattus norvegicus,Bos taurus,Ziziphus mauritiana)
• NFKB signalling pathway is involved in endogenous DcR3 expression in HUVECs stimulated by LPS, LTA and zymosan (2018, NA)
• CircRNA-miRNA interactions are potentially involved in the initiation and progression of CRC (2018, NA)
• Primer of the inflammatory cascade (2018, NA)
• Possible molecular targets of the preventive effects of PT in Cr(VI)-induced ACD (2018, NA)
• Metabolic pathway of lipid metabolism in muscle (2018, NA)
• Regulation of CFTR by the intracellular Ca2+ (2018, NA)
• Abnormalities in the DNA damage repair pathway in T cells of rheumatoid arthritis patients (2018, NA)
• Schematic elucidation of IL-33 (2018, NA)
• Anti-inflammatory mechanism of bicyclol (2018, NA)
• Interleukin-6 induces drug resistance in renal cell carcinoma (2018, NA)
• Pentraxins-expanded network of complement activation and regulation (2018, Mus musculus,Rattus norvegicus,Candida albicans,Aspergillus fumigatus,Homo sapiens,Paracentrotus lividus)
• Signaling pathway analysis of KEGG and PANTHER pathways shows that the miR‐34a/BCL‐2 axis is mostly involved in apoptotic pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• ADAR2-mediated RNA editing in metabolic disorders (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Oryctolagus cuniculus,clinical samples)
• ADAR1-mediated RNA editing in metabolic disorders (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Oryctolagus cuniculus,clinical samples)
• ADAR2-mediated RNA editing in cancer development (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Oryctolagus cuniculus,clinical samples)
• ADAR1-mediated RNA editing in cancer development (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Oryctolagus cuniculus,clinical samples)
• Hepatitis C virus-induced inflammation (2018, NA)
• Summary of the interactions between SIRT1 and the canonical Wnt pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Glucose catabolism pathways and transport systems of strain A4B-17 (2018, Escherichia coli,Mycobacterium tuberculosis,Bacillus subtilis,Corynebacterium glutamicum,Pseudomonas fluorescens,Streptomyces hygroscopicus,Zymomonas mobilis,Brucella abortus,Enterobacter cloacae,Xanthomonas campestris,Pseudomonas putida KT2440,Nostoc sp. PCC 7120 FACHB-418,Stenotrophomonas maltophilia,Pseudomonas putida S12,Brucella abortus 2308,marine bacterium SO3,Streptomyces collinus,Shimwellia blattae,Pluralibacter gergoviae,Stigmatella aurantiaca Sg a15,Marinobacterium iners,Microbulbifer echini,Microbulbifer aestuariivivens,Microbulbifer thermotolerans,Microbulbifer hydrolyticus,Burkholderia latens,Microbulbifer okinawensis,Microbulbifer chitinilyticus,Microbulbifer elongatus,Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Diaporthe sclerotioides,PX clade,Saccharum officinarum,Aspergillus oryzae,Beta vulgaris,Datura stramonium,Strongylocentrotus purpuratus,Heliocidaris crassispina,Homo sapiens,uncultured marine bacterium,NA)
• Promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy (2018, NA)
• MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer (2018, Homo sapiens,Lareunionomyces loeiensis)
• Tumor metabolism regulating chemosensitivity in ovarian cancer (2018, NA)
• Summary of the Ras/MAPK cell signalling pathway and relation with some syndromes (nonexhaustive) (2018, NA)
• FSIP1 regulates autophagy in breast cancer (2018, NA)
• General overview of the autophagic pathway and its regulators (2018, NA)
• Plant metabolic orientation of hormone interplay, carbon partitioning and responses on mycorrhizal development under high available P (2018, NA)
• Plant metabolic orientation of hormone interplay, carbon partitioning and responses on mycorrhizal development under low available P (2018, NA)
• General representation of the signaling pathways involved in CBD anticancer mediated effects (2018, NA)
• DMN-induced liver fibrosis through activating the TGFB/Smad signaling pathway and GA attenuate liver fibrosis through blocking Smad phosphorylation in liver cell (2018, NA)
• The reprogramming of metabolism in cancer (2018, Homo sapiens,Leuciscus leuciscus,Pluchea carolinensis)
• Examples of in vitro molecular action of quercetin (Q) in cited cellular experiments (2018, NA)
• Anti-HBV mechanism of TLR3 signaling of HSCs (2018, NA)
• Distribution of target proteins of SBD on the compressed ‘NSCLC-pathway.’ Four pathways form the tubular NSCLC pathway (2018, NA)
• Proposed mechanism for tobacco smoking-mediated E6/E7 overexpression (2018, NA)
• Putative mechanism is demonstrating how the loss of SEMA5A can trigger EMT (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• Molecular mechanism(s) underlying the abnormal GABAAergic system in HD (2018, NA)
• Descriptive model for the signaling pathway of nNOS in excitatory neurons (2018, NA)
• Information processing by the NFKB pathway (2018, NA)
• Schematic illustrating the role of cav-1 in different cell (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,herbal medicine,Betapolyomavirus macacae,Phoneutria nigriventer)
• Cav-1 in angiogenesis and neurogenesis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,herbal medicine,Betapolyomavirus macacae,Phoneutria nigriventer)
• Comparison of four TPs in breast cancer subtypes (2018, Homo sapiens,prion)
• Cardiac metabolic alterations in heart failure (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Candida dubliniensis)
• Autophagy and the inflammasome (2018, Mycobacterium tuberculosis,Clostridioides difficile,Chlamydia trachomatis,Citrobacter rodentium,Clostridioides difficile CD3,Clostridioides difficile CD8,Clostridioides difficile CD86,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Respiratory syncytial virus,Modified Vaccinia Ankara virus,Homo sapiens,Mus musculus)
• Schematic graphic of the mechanism underlying chondrogenesis driven by PC nanofiber membranes (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Rattus norvegicus,Naja atra)
• Egg activation in Drosophila (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Xenopus laevis)
• An involvement of reactive oxygen species in intracellular signaling (2018, NA)
• E3 modulate breast cancer cell invasion and metastasis (2018, NA)
• E3 ligases regulate breast cancer cell proliferation (2018, NA)
• Inactivation of the Hippo pathway induces breast cancer metastasis (2018, NA)
• Oxidative status and leptin signalling pathway in human mammary epithelial cells (2018, NA)
• Mechanism of HSV evades host immune responses (2018, NA)
• Altered gut microbiota is responsible for pancreatic cancer progression (2018, Escherichia coli,Helicobacter pylori,Escherichia coli IS1,Akkermansia muciniphila,Ruminococcus gnavus,Bacteroides acidifaciens,Thomasclavelia cocleata,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Gymnema sylvestre,Homo sapiens,gut metagenome)
• Adipocytokines mediate pancreatic cancer tumorigenesis by different signaling mechanisms (2018, Escherichia coli,Helicobacter pylori,Escherichia coli IS1,Akkermansia muciniphila,Ruminococcus gnavus,Bacteroides acidifaciens,Thomasclavelia cocleata,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Gymnema sylvestre,Homo sapiens,gut metagenome)
• HOG and PKA pathways collaborate to regulate glycogen and trehalose metabolism for cell wall polysaccharide precursor biosynthesis during osmotic stress conditions (2018, NA)
• Affected pathways in group 4 medulloblastoma (2018, NA)
• Consequences of driver gene mutations in canonical Wnt signaling (2018, NA)
• Affected pathways in SHH-activated medulloblastoma (2018, NA)
• The activation of Wnt/Beta-catenin signaling by different oncogenic lncRNAs in liver cancer (2018, NA)
• Canonical pathway analysis using MetaCore identified EGFR, PDGFR, and mTOR signalling as the top 3 canonical pathways modulated in FCD type II patients (2018, NA)
• Tankyrase-mediated Wnt/Beta-catenin signalling (2018, NA)
• Proposed roles for miR-137 at the glutamatergic synapse (2018, NA)
• Neuronal signaling events that influence miRNA biogenesis, activity, and degradation (2018, NA)
• Lysophosphatidic Acid 's effects on ion channel regulation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Delphinus delphis)
• Proposed TLR 2, 5, 8 signaling pathway (2018, teleost fish,Acipenser schrenckii,Huso dauricus,Aeromonas hydrophila,Homo sapiens)
• IL-20 receptor cytokines and their receptors (2018, NA)
• Schematic illustrating the potential contributions of ADAM9 (a disintegrin and metalloproteinase domain-9) to various chronic obstructive pulmonary disease phenotypes (2018, Homo sapiens,Mus musculus)
• Central metabolic pathway of representative carbon sources in model iZBM1060 (detailed information on enzyme information and reactions are presented in Supplementary Table ) (2018, NA)
• Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway (2018, Homo sapiens,Bos taurus,Arabidopsis thaliana,Human immunodeficiency virus 1)
• Protein-protein interaction map of the TNF-induced NFKB signal transduction pathway (2018, Homo sapiens,Bos taurus,Arabidopsis thaliana,Human immunodeficiency virus 1)
• Schematic diagram of FOXO1-mediated miR-3188-mTOR-p-PI3K/AKT-c-Jun signaling feedback loop in NSCLC (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Pathways involved in hyperglycemia-induced neuroinflammation (2018, NA)
• Proposed mechanisms of anthocyanin’s effect on NVU dysfunction after ischemic stroke (2018, Mus musculus,Rattus norvegicus,Cricetulus griseus,Scapteromys aquaticus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Lycium ruthenicum)
• Scheme illustrating the signaling pathways and transcription factors contributing to SND1 promoter activation (2018, Drosophila melanogaster,Caenorhabditis elegans,Plasmodium falciparum,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio,Human gammaherpesvirus 4)
• String pathway enrichment analysis revealed strong associations (P=0.007) of the identified prognostic genes (colored nodes) (2018, NA)
• Model proposing ROCK inhibition mediates morphological shift and neurite outgrowth-promoting property of OECs (2018, NA)
• Cell survival and apoptotic pathway in AD therapy.Notes: Action of WGA-CRM-CL/LIPs: Curcumin inhibits phosphorylation of JNK and p38, preventing downstream phosphorylation of tau serine 202, leading to prevention of apoptotic neurodegeneration (2018, NA)
• Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study (2018, Homo sapiens,Mus musculus)
• Post-transcriptional regulation of cytokine expression and signaling (2018, NA)
• Two synthesis pathways of fucosylation (2018, Pisum sativum,Lens culinaris,Aleuria aurantia,Homo sapiens,Mus musculus,Sus scrofa,Triportheus paranensis)
• Intrinsic and extrinsic apoptosis pathway (2018, Porphyromonas gingivalis,Fusobacterium nucleatum,Streptococcus mutans,Homo sapiens,Mus musculus,Human gammaherpesvirus 8)
• Targeted metabolic regulation in ADPKD (2018, NA)
• TPS EGF Response Pathway Model (2018, NA)
• Gene-level alterations in muscle-invasive bladder cancer in the context of curated pathways (2018, Homo sapiens)
• TREM2 molecular signaling in microglia, initiating phagocytosis and microglial survival or modulating proinflammatory response, is not well characterized so only validated components are displayed (2018, NA)
• Proposed pathway of anti-tumor effects of propofol on lung cancer A549 cells (2018, NA)
• Hypothesied pathway showing the inhibitory mechanism of cyclin G2 on Wnt/Beta-catenin signaling through Dpr1 (2018, NA)
• CRC risk associated with metabolic incorporation of non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) from red meat (2018, NA)
• Signaling pathway of defensins and interleukins gene expression is regulated by PBA in porcine intestinal epithelial cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Staphylococcus aureus,Mycobacterium tuberculosis,Porcine epidemic diarrhea virus,JC polyomavirus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Nobiletin-induced apoptosis and suppressed migration and proliferation of human breast cancer cells via regulating p38 MAPK, NFKB pathway, and Nrf2 pathway (2018, Citrus reticulata,Citrus aurantium,Citrus nobilis,Homo sapiens,Mus musculus,Bos taurus)
• Transforming growth factorB1 up-regulates connexin43 expression in osteocytes via canonical Smad-dependent signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Canonical and non-canonical inflammasome signaling pathways.Notes: The figure describes both the canonical and non-canonical signaling pathways involved in the activation of different inflammasome components including NLRP1, NLRP3, NLRC4, and AIM2 (2018, NA)
• Components of the phosphoinositide 3-kinase (PI3K) signaling pathway and its associated therapeutic targets (2018, Homo sapiens,Mus musculus,Nicotiana tabacum,Human papillomavirus)
• Mechanism model of PIK3CA E542K and E545K mutation-mediate regulation of proliferation and glucose metabolism via the Beta-catenin/SIRT3 in cervical cancer (2018, NA)
• Proposed pathway for the protective effects of metformin against DM-induced disorders on atrial SK2 and SK3 channels (2018, Homo sapiens,Macaca fascicularis,Rattus norvegicus,Armoracia rusticana,Capra hircus)
• Top two networks (A and B) identified by Ingenuity Pathway Analysis as overrepresented within the list of 245 genes (P < 0.005) dysregulated in human IAPP transgenic (HIP) vs (2018, NA)
• DT-13 promoted mitochondrial apoptosis and inhibited metastasis via suppressing PI3K/Akt pathway (2018, NA)
• CBL0137 exhibits its antitumor activity via multiple pathways (2018, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio)
• Bioinformatic analysis of differentially expressed proteins (DEPs) identified in this study (2018, NA)
• Does Axl have potential as a therapeutic target in pancreatic cancer? (2018, Mouse mammary tumor virus,Zika virus,Zaire ebolavirus,Mus musculus,Rattus norvegicus,Homo sapiens)
• B cell receptor (BCR) signaling pathways (2018, Helicobacter pylori,Chlamydia psittaci,Homo sapiens,NA)
• Main lipid-lowering effects of berberine through the APMK pathway (2018, Homo sapiens,Coptis chinensis)
• JAK2 overexpression alleviates C2C12 myoblasts I/R injury through the AKT and ERK1/2 pathway (2018, NA)
• Genetic determinants of cardiovascular risk in SLE (2018, NA)
• The involvement of several TMEMs in tumor growth through the TGFB signaling pathway (2018, Homo sapiens,Mus musculus,Citrus macrophylla)
• A molecular mechanism for AA effect on learning strategy (2018, NA)
• Proposed mechanisms by which Adam8 deficiency in leukocytes and/or lung parenchymal cells leads to exaggerated cigarette smoke (CS)-induced chronic obstructive pulmonary disease in mice (2018, NA)
• Regulatory model for the flow pathway of central carbon metabolism and a proposed scheme for lipid biosynthesis in T (2018, Tribonema minus,Homo sapiens)
• Moderate heat stress induces nerve growth factor (NGF) signaling including downstream activation of AKT and ERK as well as cyclic AMP responsive element-binding protein 1 (CREB1) transactivation (2018, NA)
• Role of the APC tumor suppressor gene in signaling expression of genes regulating the polyamine pathway (2018, Homo sapiens,Mus musculus)
• Polyamine biosynthetic pathway in single-celled parasitic eukaryotes (2018, NA)
• MAP of “p53 Signaling” pathway in (A) HSAEC and (B) A549 cells treated with 1 μM PG over 24 h (2018, Homo sapiens,Bos taurus,Serratia marcescens,Taxus brevifolia)
• ADE of viral infections (2018, Human immunodeficiency virus 1,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,H1N1 subtype,Vesicular stomatitis virus,Zika virus,West Nile virus,Ebola virus,Measles morbillivirus,Japanese encephalitis virus,Sindbis virus,Chikungunya virus,Porcine reproductive and respiratory syndrome virus,Lyssavirus rabies,Foot-and-mouth disease virus,Human coronavirus NL63,Human orthopneumovirus,Influenza A virus H3N2,Human metapneumovirus,Dengue virus group,Zaire ebolavirus,Ross River virus,Swine influenza virus,Chimpanzee adenovirus,Dengue virus type 3,H1N2 subtype,Murray Valley encephalitis virus,Oryctolagus cuniculus,Sus scrofa,Mustela putorius furo,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Lareunionomyces loeiensis,NA,NA)
• Mammalian mTORC1-dependent ribosomal transcription (2018, NA)
• Molecular actions of CTLA-4 and PD-1 on inhibiting T cell function (2018, NA)
• Scheme summarizing the protective effects of UTI on LPS-induced RAW264.7 cells (2018, NA)
• MALAT1 in cancer pathways.Notes: MALAT1 promotes generation of the six phenotypes of cancer (2018, NA)
• Protein–protein network and pathway analysis (2018, Mus musculus,Rattus norvegicus,Armoracia rusticana,Rhodiola rosea,Homo sapiens,Oryctolagus cuniculus)
• Expression differences within the IIS/TOR pathway for the four comparison types (2018, NA)
• Expression differences in males and females in response to reduced insulin signaling for immune response genes (2018, NA)
• HCV life cycle and involved Rab proteins (2018, Hepatitis B virus,Dengue virus,Zika virus,West Nile virus,Oryza sativa,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,NA,NA,NA)
• Epidermal growth factor receptor pathway in patients with wild-type and mutant BRAF and KRAS (2018, NA)
• Summary of the potential mechanisms of vaccine NSEs (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Haemophilus influenzae,Mycobacterium tuberculosis variant bovis,Bordetella pertussis,Staphylococcus aureus CI11,H1N1 subtype,Measles morbillivirus,Variola virus,Variola minor virus,Bos taurus,Canis lupus familiaris,Sus scrofa,Solanum tuberosum,Candida albicans,Vasconcellea candicans,Homo sapiens,Mus musculus,Schistosoma mansoni)
• Effect of different preconditioning stimuli in the MSCs response (2018, NA)
• Key interconnected metabolic pathways and their relevance to mTORC1 activation (2018, NA)
• Schematic diagram showing the possible pathways involved in the activation of astroglial Cx43 hemichannels and Panx1 channels evoked by in vivo ethanol exposure during adolescence (2018, NA)
• Vasorin 3D structure: Cartoon representation of the structure model of Vasn predicted by RaptorX (http://raptorx.uchicago.edu/) (2018, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Homo sapiens,Danio rerio)
• Mitogen-activated protein kinase pathway (2018, NA)
• Putative inhibitory pathway of Ac-ME in mediating the inflammatory response (2018, NA)
• Overview of complement cascade activation and targets of inhibitors (2018, NA)
• Possible mechanisms of synergistic actions of the LABA/LAMA combination against inflammation (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Escherichia coli)
• KEGG analysis of hsa-miR-210 target genes (2018, Homo sapiens,Helicobacter pylori,clinical samples)
• Schematic representation illustrating the signaling molecules that regulate the PD-1/PD-L1 transcription (2018, NA)
• Proposed role of BCaMKII in regulation of COX-2/PGE2 neuroinflammatory signaling pathway and depression-like behaviors (2018, NA)
• Zinc and zinc transporters are involved in FcERΙ-mediated mast cell activation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1 (2018, NA)
• Known and novel BP associations in the TGFB signalling pathway (2018, Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus,cellular organisms)
• Schematic model illustrating that miR-10b mediated function in osteogenic and adipogenic differentiation of hADSCs (2018, NA)
• Regulatory effects of miR-1292 on hADSC senescence and osteoblastic differentiation (2018, Homo sapiens,Pan troglodytes,Pongo pygmaeus,Mus musculus,Bos taurus,Drosophila melanogaster,Mouse mammary tumor virus)
• Mechanism of post-operative neuroinflammation.DAMPs and PAMPs activate the downstream pathway involved in inducing the production of TNFA, as well as other proinflammatory mediators via NFKB (2018, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome)
• E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling (2018, NA)
• TF cascades under glucagon control (2018, NA)
• Mitochondrial quality control mechanisms as molecular targets in cardiac ageing (2018, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Drosophila melanogaster,Vasconcellea candicans)
• Mitochondrial quality control mechanisms as molecular targets in cardiac ageing (2018, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Drosophila melanogaster,Vasconcellea candicans)
• Mitochondrial quality control mechanisms as molecular targets in cardiac ageing (2018, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Drosophila melanogaster,Vasconcellea candicans)
• The TLR pathway and let-7e target mRNAs (2018, NA)
• Triacylglycerol (TAG) lipolysis in Drosophila: biochemistry and main regulatory pathways (2018, NA)
• Triacylglycerol (TAG) synthesis in Drosophila: biochemistry and main regulatory pathways (2018, NA)
• Summarization of DDT pathway selection in spn1 strains (2018, NA)
• Retrograde neurotrophic signalling organelles and their main destinations after arrival to the cell body (2018, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Drosophila melanogaster,Corynebacterium phage gamma)
• lncRNAs regulate hepatic fibrosis via TGFB signaling pathway (2018, Homo sapiens,Mus musculus,Clonorchis sinensis)
• Increased P2X4R expression after nerve injury via the actions of fibronectin in activated microglia (2018, NA)
• Schematic figure for PTS-mediated signaling pathways (2018, NA)
• Schematic illustration representing metabolic and transport proteins hypothesized from the genome of Ca (2018, Pseudothermotoga lettingae TMO,Schnuerera ultunensis,Marine benthic group Euryarchaeota,Thiovulum sp.,metagenome,metagenomes,uncultured archaeon,Homo sapiens,Bos taurus)
• Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions (2018, NA)
• LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA (2018, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,clinical samples)
• PHIPing along: Evolution of PHIP as a cancer biomarker and a target for therapy (2018, Homo sapiens,Mus musculus)
• Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood (2018, Bos taurus,Eutheria,Homo sapiens,Mus musculus)
• Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Felis catus,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Plasmid pTF1)
• Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Felis catus,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Plasmid pTF1)
• Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Felis catus,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Plasmid pTF1)
• Analysis of the transcriptome data in Litopenaeus vannamei reveals the immune basis and predicts the hub regulation-genes in response to high-pH stress (2018, NA)
• IFN-JAK-STAT signaling pathway (2018, NA)
• Cross-talk among different signaling pathways involved in MDSCs expansion, activation and function (2018, NA)
• Integrated Analysis Reveals Genomic and Expression Alterations in Signaling Pathways in HNSCC Differing in HPV Status (2018, Nicotiana tabacum,Human papillomavirus,Matthiola incana,Human papillomavirus type 16,Homo sapiens,Mus musculus,clinical samples,Venustaconcha ellipsiformis)
• Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches (2018, NA)
• Crosstalk between surface TLRs and dysregulated metabolic factors in diabetes (2018, NA)
• Antitumor effects of emodin and chrysophanic acid (2018, NA)
• Effect of resveratrol on the proliferation, invasion, metastasis, and apoptosis of tumor cells (2018, NA)
• Cholesterol biosynthetic pathway and relative expression changes for genes encoding related enzymes (2018, Gallus gallus,Danio rerio,teleost fish,Cyprinus carpio,Dipnomorpha,Astyanax mexicanus,Barbus barbus,Sinocyclocheilus grahami,Psalidodon fasciatus,Astyanax hubbsi,Sinocyclocheilus tingi,Sinocyclocheilus angustiporus,Sinocyclocheilus anophthalmus,Homo sapiens,Mus musculus)
• Impact of i-proteasome subunits on innate immune signaling in myeloid cells (2018, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Vaccinia virus,Enterovirus C,Coxsackievirus B3,Coxsackievirus,Human betaherpesvirus 6,Human papillomavirus types,Human parvovirus B19,Aurantiochytrium single-stranded RNA virus 01,Murine adenovirus 1,Minute virus of mice,Mus musculus,Cricetulus griseus,Cricetus cricetus,Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Canis lupus familiaris,Listeria monocytogenes,NA)
• Processes of liver fibrosis progression and regression during human hepatosplenic schistosomiasis (2018, Schistosoma mansoni,Schistosoma japonicum,Schistosoma haematobium,Homo sapiens,Mus musculus)
• Network visualization of top primary hits (2018, NA)
• Schematic model of HPV-driven carcinogenesis (2018, NA)
• PD-L1/PD-1 signaling pathway and the correlated network (2018, NA)
• Targeted therapy for recurrent/metastatic head and neck cancers (2018, NA)
• Resistance to MET and MET/MAPK/ERK inhibition in DFCI358 (2018, NA)
• Biochemical basis of disease (2018, Nicotiana tabacum,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Malus domestica,Arachis hypogaea,Spinacia oleracea,Pyrus communis,Helicobacter pylori,Vibrio cholerae,bacterium V,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Dipturus trachyderma,NA)
• Sensing danger through a “finger” (2018, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• Identification of Key Differentially Expressed MicroRNAs in Cancer Patients Through Pan-cancer Analysis (2018, Homo sapiens,Mus musculus,Ganoderma lucidum)
• Proposed signal pathway with THSG and ADM in MCF-7 cells.Abbreviations: ADM, Adriamycin; THSG, 2,3,5,4′-Tetrahydroxystilbene-2-O-Beta-d-glucoside (2018, NA)
• Postulated cellular mechanisms of 20-HETE bioactions in the blood vessel wall (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Castor fiber,Homo sapiens,Candida dubliniensis)
• Proposed schematic diagram of the PNS protection on BBB endothelial cells (2018, NA)
• High-energy donor UDP-GlcNAc is provided by the hexosamine biosynthetic pathway (HBP) and is connected to UDP-GalNAc and CMP-NeuAc (2018, Danio rerio,Xenopus laevis,Triportheus paranensis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Homo sapiens,Sus scrofa)
• The main molecular pathways linked to inflammatory and immunomodulatory activities modulated by Curcumin and Echinacea (2018, NA)
• Schematic summary of the possible mechanism for GLCCI1 in glucocorticoids pathway (2018, NA)
• Repeated morphine treatment on glial and neuronal signaling in the PAG (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Phytomonas oxycareni)
• Effects of morphine on neuronal transmission in the descending pain pathway (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Phytomonas oxycareni)
• Mechanisms of DMTN in the invasion and metastasis of CRC (2018, NA)
• Subolesin/Akirin function in immune response pathways (2018, Drosophila melanogaster,Caenorhabditis elegans,Anopheles gambiae,Plasmodium berghei,Aedes albopictus,Branchiostoma lanceolatum,Ixodes scapularis,Penaeus vannamei,Rhipicephalus microplus,Ixodes ricinus,Amblyomma americanum,Penaeus japonicus,Ornithodoros moubata,Ixodes persulcatus,Haemaphysalis longicornis,Caligus rogercresseyi,Rhipicephalus appendiculatus,Dermacentor reticulatus,Amblyomma hebraeum,Ornithodoros erraticus,Crassostrea hongkongensis,Amblyomma cajennense,Ornithodoros savignyi,Amblyomma triste,Ornithodoros turicata,Amblyomma variegatum,Rhipicephalus annulatus,Dermanyssus gallinae,Babesia bigemina,Drosophila mauritiana,Hyalomma anatolicum,Rhipicephalus haemaphysaloides,Hyalomma excavatum,Hyalomma marginatum,Dermacentor marginatus,Amblyomma aureolatum,Ixodes hexagonus,Ornithodoros rostratus,Dermacentor silvarum,Rhipicephalus decoloratus,Rhipicephalus evertsi,Rhipicephalus zambeziensis,Rhipicephalus bursa,Rhipicephalus pulchellus,Hyalomma rufipes,Danio rerio,Xenopus laevis,Salmo salar,Paralichthys olivaceus,Scophthalmus maximus,Oplegnathus fasciatus,Abramis brama,Hippocampus abdominalis,Paramisgurnus dabryanus,Bos taurus,Oryctolagus cuniculus,Ovis aries,Cervus elaphus,Odocoileus virginianus,Eucalyptus intertexta,Borreliella burgdorferi,Ricinus communis,Anaplasma phagocytophilum,Anaplasma marginale,Desulfosarcina variabilis,Dipentodon sinicus,Arum maculatum,Mus musculus,Rattus norvegicus,Homo sapiens,Vaccinia virus)
• Major signaling pathways and therapeutic targets in CLL cells (2018, Homo sapiens,Mus musculus)
• Proposed pathway of antitumor effects of SDA in PCa cells (2018, NA)
• Main brain-immune system pathways and feedback loops illustrating the interconnected effects of physical and emotional stress in health (2018, Homo sapiens)
• Iron metabolism in prostate cancer microenvironment (2018, Homo sapiens,Mus musculus,Curcuma longa)
• Genetics and molecular pathways for PPGLs Pathways for the New Genes; Placing the New into Perspective (2018, NA)
• Final figure summarizing the major findings of this study and showing the integration of the lncRNA–microRNA–mRNA network and epigenetic regulation pathways (2018, NA)
• Mechanisms linking U34-enzymes to melanoma cell survival and resistance to targeted therapy (2018, Homo sapiens,Danio rerio)
• Proposed model of glycogen synthesis regulation by insulin in endometrial epithelial cells to provide nutrition to an implanted embryo (2018, NA)
• Signaling pathways in osteoclasts involving V-ATPases (2018, Homo sapiens,Mus musculus)
• NOTCH signaling pathway (2018, NA)
• T helper cell differentiation signaling pathway (2018, Homo sapiens)
• Proposed pathway for the complete utilization of carbaryl as the carbon and nitrogen source in Pseudomonas sp (2018, NA)
• Molecular pathways of the neuro-immune hemostasis model (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Notolabrus celidotus)
• Possible model of Leptin and Immune response in malnutrition coupled infectious diseases (2018, NA)
• Representative image of the participation of SARA in the TGFB signaling pathway (2018, NA)
• RA’s signaling via the RAR-RXR pathway (2018, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Homo sapiens,Helicobacter pylori)
• Schematic representation summarizing the transforming growth factors-beta (TGFB) receptor complexes and signaling pathway in endothelial cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,unidentified)
• Insulin signalling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Representative model of leptin-induced EMT signaling (2018, NA)
• Theoretical Studies on the Engagement of Interleukin 18 in the Immuno-Inflammatory Processes Underlying Atherosclerosis (2018, Nicotiana tabacum,Neopyropia yezoensis,Homo sapiens,Mus musculus)
• Non-Structural Proteins from Human T-cell Leukemia Virus Type 1 in Cellular Membranes—Mechanisms for Viral Survivability and Proliferation (2018, NA)
• Maternal Beta-Cell Adaptations in Pregnancy and Placental Signalling: Implications for Gestational Diabetes (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGFB signaling in palatal fusion (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Turdus migratorius)
• Response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) relies on destroying cancer cells as well as on breaking the stromal barrier and flaring up immune function (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Hepatitis B virus,Listeria monocytogenes)
• IL-24 activates PKA to induce apoptosis in breast cancer cells (2018, NA)
• The role of AMPK in class IIa histone deacetylases traffic in rat soleus muscle at the initial stages of gravitational unloading (2018, NA)
• Cartoon showing the major signaling pathways targeted by phytochemicals in cancer (2018, NA)
• The biological activities of KM and its effects on the AGE-induced mitochondrial/cytochrome c-mediated apoptosis pathway in GMCs (2018, Armoracia rusticana,Magnoliopsida,Andrographis paniculata,Fallopia multiflora,Phyllanthus niruri,Toona sinensis,Bauhinia forficata,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Schema illustrating the regulation of the autophagic pathway under diverse stressful conditions in cancer cells (2018, NA)
• Schematic diagram showing the effects of Kir4.1 inhibition on neuronal excitability and astrocytic BDNF expression (2018, NA)
• Basic TGFB signaling diagram along with a program of TGFBeta-regulated genes that contribute to the EMT (2018, NA)
• Targeting HGF/c-MET pathway in digestive system cancers by microRNAs (2018, NA)
• Schematic diagram of c-mesenchymal–epithelial transition (c-MET) activation signaling pathways (2018, NA)
• Three apoptotic pathways (Extrinsic, intrinsic and granzyme pathways) (2018, NA)
• The feedback regulation of AMPK by protein acetylation (2018, NA)
• NOD1 signaling cascade (2018, NA)
• Metabolism of sphingolipids (2018, Homo sapiens,Mus musculus,Danio rerio,clinical samples)
• Mechanism of effect of exercise and middle-age on cardiac hypertrophy (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Thymus vulgaris,Antarctothoa delta)
• Role of Hippo signaling in regulating immunity (2018, Homo sapiens,Drosophila melanogaster)
• Effect of SPPL2a deficiency on IFNG machinery (2018, NA)
• General mechanism of Wnt induction (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Xenopus laevis,Mouse mammary tumor virus,murine stem cell retroviral vector)
• Agronomic Linked Data (AgroLD): A knowledge-based system to enable integrative biology in agronomy (2018, NA)
• Diagramatic representation of the proposed signaling mechanisms mediating FGF2 versus S117A-FGF2 protection from Dox-induced damage (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Role of the innate and adaptive immune cells following the irradiation of tumour cells (2018, NA)
• Core analyses network predictions for HBoV-infected CuFi-8 cells (2018, NA)
• Main components of the Hippo pathway and the current Hippo-targeted inhibitors discussed in this review (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Systemic effects of increased adiposity on EC progression (2018, NA)
• Contributions of activated/recruited stromal cells in endometrial cancer (EC) progression (2018, NA)
• KDM5A function and its expression control in proliferating NPC and differentiating astrocyte (2018, NA)
• Glutamine inter-tissue metabolic flux starting in skeletal muscle, liver, and gut continues in the immune cells (2018, NA)
• Regulatory effects on immune-related pathways induced by a group of compounds from health-strengthening herbs (2018, Diaporthe sclerotioides,herbal medicine,Panax ginseng,Schisandra chinensis,Nelumbo nucifera,Engelhardia roxburghiana,Rheum tanguticum,Dioscorea polystachya,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Molva molva)
• Updated model of iMCD pathogenesis (2018, NA)
• Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway (2018, Armoracia rusticana,Salvia miltiorrhiza,Ganoderma lucidum,Hibiscus sabdariffa,Alkekengi officinarum,Alkekengi officinarum var. franchetii,Homo sapiens,Mus musculus,Equus caballus)
• Altered PI3K/Akt pathway during normal and insulin resistance (2018, Homo sapiens,Rattus norvegicus,Helicobacter pylori)
• Model-based in silico analysis of the PI3K/Akt pathway: the elucidation of cross-talk between diabetes and breast cancer (2018, Homo sapiens,Rattus norvegicus,Helicobacter pylori)
• MiRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults (2018, NA)
• Netrin-1 signaling pathways (adapted from ) (2018, NA)
• SIRT1 protects against cerebral ischemic injury in multiple mechanisms (2018, NA)
• Regulative mechanisms of brain SIRT1 in metabolic homeostasis (2018, NA)
• Triggering receptor expressed on myeloid cells-2 (TREM2) in microglial survival and metabolism (2018, NA)
• Calcium ion signaling through microglial ion channels (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Tumor necrosis factorA pathway for necroptosis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Salmonella enterica subsp. enterica serovar Typhimurium)
• Immune-related features and pathways predictive of response to immune checkpoint blockade (2018, gut metagenome,clinical samples,Homo sapiens,Mus musculus,Akkermansia muciniphila,Human endogenous retroviruses)
• Comparative Genomics Supports Sex and Meiosis in Diverse Amoebozoa (2018, Tetrahymena thermophila,Amoebozoa,Schizosaccharomyces pombe,Homo sapiens)
• CRISPR/Cas9-based approaches for modeling kidney disease (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Zika virus,Metatheria,NA)
• Nuclear factor-kappa B signaling pathway (2018, NA)
• Significant deregulated key signaling nodes of JAK-Wnt signaling axis are represented in Jurkat cells after treatment with N4-Eru (2018, Diaporthe sclerotioides,Vaccinium myrtillus,Lessertia frutescens,Homo sapiens,Rattus norvegicus,Bos taurus)
• JAK-STAT signaling pathway after treatment with N4-Eru (2018, Diaporthe sclerotioides,Vaccinium myrtillus,Lessertia frutescens,Homo sapiens,Rattus norvegicus,Bos taurus)
• Notch signaling pathway after treatment with N4-Eru (2018, Diaporthe sclerotioides,Vaccinium myrtillus,Lessertia frutescens,Homo sapiens,Rattus norvegicus,Bos taurus)
• Metabolic pathways involved in glucose, fructose, and xylose catabolism in B (2018, Escherichia coli,Bacillus subtilis,Pseudomonas putida,Bacillus subtilis At2,Clostridium acetobutylicum,Pseudomonas putida KT2440,Priestia megaterium,Thermobifida fusca,Pseudomonas protegens Pf-5,Priestia megaterium QM B1551,Saccharomyces cerevisiae,Homo sapiens)
• Canonical hedgehog signaling pathway (2018, Homo sapiens)
• Neurotrophic factor (NTFs) signaling pathways (2018, NA)
• Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1 (2018, NA)
• Role of macrophages in hepatitis C virus infection-associated inflammation (2018, NA)
• Scheme to explain how CP-AMPARs may trigger LTP2 (2018, NA)
• Potential mechanisms involved in propagation of Alpha-syn (2018, NA)
• Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Matthiola incana,Homo sapiens,Gallus gallus)
• Delving deeper: Relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis (2018, NA)
• MTOR pathway in treatment of epilepsy: a clinical update (2018, NA)
• Nrf2–Keap1 signaling pathway (2018, Mus musculus,Homo sapiens)
• Different gene expression profiles in metabolic pathways of E (2018, Escherichia coli,Bacillus subtilis At2,Escherichia coli str. K-12 substr. MG1655,Moorella thermoacetica,Clostridium ljungdahlii,Acetobacterium woodii,Clostridium autoethanogenum,Eubacterium limosum,Clostridium ljungdahlii DSM 13528,Carboxydothermus hydrogenoformans,Clostridium aceticum,Eubacterium limosum KIST612,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Effects of the metabolite, RA, on Tregs (2018, NA)
• Low pH induces differentiation of T cell into Tregs (2018, NA)
• Hypoxia induces differentiation of T-cells to Tregs (2018, NA)
• Microenvironment recruits Tregs to tumor tissue by chemotaxis (2018, NA)
• Effect of glycolysis on Tregs (2018, NA)
• Flavonoids downregulate mdr1 expression through wnt/Beta-catenin signaling pathway (2018, NA)
• JAK1 may be the target molecule of (+)-terrein in the IL-6 signaling pathway in HGFs (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Aspergillus terreus,Aspergillus pulvinus,Homo sapiens,Mus musculus,Xenopus laevis,NA)
• Scheme summarizing the protective effects of miR-27a on LPS-induced acute lung injury via the inhibiting TLR4/MyD88/NFKB activation (2018, NA)
• CREB1 signaling is predicted to be altered by ID (2018, Homo sapiens,Mus musculus)
• Pathway network and MAPK signaling (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Gallus gallus,Candida dubliniensis)
• Pictorial Abstract showing that the molecular or therapeutic inhibition of TRPM7 expression and/or activity attenuates the cancer stem cell-like and metastatic phenotypes of lung cancer cells through the modulation of the Hsp90A/uPA/MMP2 signaling (2018, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Molva molva,Sarcothelia edmondsoni)
• Pathway relationship network of TGFB1 and −2 treatment-related DEGs (2018, NA)
• Pathway relationship network of glaucoma-related DEGs (2018, NA)
• Presumable molecular mechanisms induced by fasting and anticancer treatment to promote intracellular changes and autophagy induction in tumor cells (2018, NA)
• Tankyrase function in cancer (2018, NA)
• Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility (2018, NA)
• Targets of BA, JA, and BJ in the CD27 signaling pathway in lymphocytes (2018, Mus musculus,Scutellaria baicalensis,Homo sapiens)
• Schematic summary of molecular mechanisms for duhuo jisheng decoction (DHJSD) on the lower back pain (LBP) caused by Bi Zheng (2018, NA)
• Proposed anti-inflammatory pathway of beauvericin (BEA) in macrophages (adapted from Yoo et al., ) (2018, NA)
• Mechanisms whereby betaine inhibits IL-1B release (2018, NA)
• Non-canonical mechanisms whereby betaine inhibits IL-1B production (2018, NA)
• Transcriptome response of Salvia miltiorrhiza to overexpression of AtPAP1 (2018, Salvia miltiorrhiza)
• Canonical IRF5 signaling pathway and its negative regulation (2018, NA)
• Detection of volatile pheromones on the antenna (2018, NA)
• Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation (2018, Armoracia rusticana,Catharanthus roseus,Taxus brevifolia,Azadirachta indica,Podophyllum peltatum,Ambrosia maritima,Garcinia schomburgkiana,Escherichia coli,Escherichia coli 27A,Escherichia coli SCD1,Escherichia coli PA2,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Cricetus cricetus)
• Summarized Ca2+ Signaling pathway by S1P (2018, NA)
• Roles of SIRT7 in cancer (2018, NA)
• SIRT7 maintains genome stability through multiple pathways (2018, NA)
• Regulators of glioma cancer stem-like quiescence in the niche (2018, NA)
• Molecular mechanisms underlying cell cycle by cancer stem-like cells (2018, NA)
• aspartate Beta-hydroxylase (ASPH) may affect the progression of pancreatic cancer through the activation of Notch signaling pathway (2018, NA)
• Transcriptional regulation of aspartate Beta-hydroxylase (ASPH) (2018, NA)
• Innate immunity and adaptive immunity (2018, NA)
• Involvement of Akt in Mitomycin C and Its Analog Triggered Cytotoxicity in MCF-7 and K562 cancer cells (2018, Armoracia rusticana,Sequoia sempervirens,Homo sapiens)
• Regulation of the autophagy pathway (2018, NA)
• Inflammatory response and cell death after stroke (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Punica granatum,Homo sapiens,Oryctolagus cuniculus)
• Three modes of programmed cell death (2018, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Murid betaherpesvirus 1,Reovirus sp.,Mus musculus,Rattus norvegicus,Homo sapiens)
• Oxidative stress and activation of Cerebrovascular Endothelial Cells (2018, NA)
• Proposed working model underpinning that decreased ATF4 disrupted ovulation (2018, NA)
• Therapeutic targeting of the FOXM1 genetic network in myeloma (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Venustaconcha ellipsiformis,Bikinia letestui)
• Implication of microglia in the development of Alzheimer's disease (2018, NA)
• X4-gp120 activated signaling pathways involved in the activation of TNFA and IL-10 gene expression (2018, NA)
• Keap1-dependent and Keap1-independent mediated Nrf2 signaling (2018, Glycine max,Candida dubliniensis,Candida albicans,Malus domestica,Olea europaea,Curcuma longa,Camellia sinensis,Allium cepa,Salvia miltiorrhiza,Daucus carota,Phaseolus vulgaris,Zingiber officinale,Raphanus sativus,Punica granatum,Scutellaria baicalensis,Petroselinum crispum,Salvia rosmarinus,Tripterygium wilfordii,Fagopyrum esculentum,Angelica sinensis,Syzygium aromaticum,Picea abies,Schisandra chinensis,Humulus lupulus,Magnolia officinalis,Taxus chinensis,Rhodiola rosea,Myrrhis odorata,Capparis spinosa,Cymbopogon citratus,Pseudotsuga menziesii,Ligustrum lucidum,Camellia sinensis var. sinensis,Dioscorea nipponica,Scutellaria lateriflora,Lagerstroemia speciosa,Orthosiphon stamineus,Cedrus deodara,Taiwanofungus salmoneus,Khaya senegalensis,Carex distachya,Centranthera grandiflora,Pinus roxburghii,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Helicobacter pylori,Coturnix coturnix,NA,NA)
• Natural products activating Nrf2 signaling pathway (2018, Glycine max,Candida dubliniensis,Candida albicans,Malus domestica,Olea europaea,Curcuma longa,Camellia sinensis,Allium cepa,Salvia miltiorrhiza,Daucus carota,Phaseolus vulgaris,Zingiber officinale,Raphanus sativus,Punica granatum,Scutellaria baicalensis,Petroselinum crispum,Salvia rosmarinus,Tripterygium wilfordii,Fagopyrum esculentum,Angelica sinensis,Syzygium aromaticum,Picea abies,Schisandra chinensis,Humulus lupulus,Magnolia officinalis,Taxus chinensis,Rhodiola rosea,Myrrhis odorata,Capparis spinosa,Cymbopogon citratus,Pseudotsuga menziesii,Ligustrum lucidum,Camellia sinensis var. sinensis,Dioscorea nipponica,Scutellaria lateriflora,Lagerstroemia speciosa,Orthosiphon stamineus,Cedrus deodara,Taiwanofungus salmoneus,Khaya senegalensis,Carex distachya,Centranthera grandiflora,Pinus roxburghii,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Helicobacter pylori,Coturnix coturnix,NA,NA)
• Biosynthetic pathway of adenosylcobalamin (2018, NA)
• 13C metabolic flux analysis and RNASeq explain the overflow metabolism (2018, Komagataella phaffii,Homo sapiens)
• Overview of Cdc5 functions in key cell cycle pathways (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio)
• Pathway analysis infers molecular pathway of relapse (2018, Homo sapiens)
• Somatic mutations of the canonical signal transduction and tumor suppressor pathways in HCC (2018, Iris germanica,Phleum pratense,Homo sapiens,Bos taurus)
• Paeonol protects against atherogenesis (2018, Candida dubliniensis,Panax notoginseng,Paeonia suffruticosa,Bupleurum falcatum,Angelica dahurica,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Coturnix coturnix)
• Metabolic reprogramming in HCC (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Hepatitis B virus)
• Proposed role of macrophage LRP1 depicted in diet-induced inflammatory conditions (2018, NA)
• Insulin signalling pathway in cells of patients with type 2 diabetes mellitus (2018, NA)
• Insulin signalling pathway in normal cells (2018, NA)
• Moderate-intensity continuous training (MICT) increases intracellular calcium (Ca2+) levels in neurons through the NMDA receptor (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways subverted in T-cell oncogenesis (2018, NA)
• Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria (2018, Homo sapiens)
• RAS signaling pathway with proteins mutated in JMML in red (2018, Homo sapiens)
• Updated model of iMCD pathogenesis (2018, NA)
• Novel agents targeting inflammation in SCD (2018, NA)
• Attenuating Effects of 1,2,3,4,6 Penta-O-Galloyl-Beta-D-Glucose on Pro-Inflammatory Responses of LPS/IFNGamma-activated BV-2 Microglial Cells through NFƙB and MAPK Signaling Pathways (2018, Armoracia rusticana,Camellia sinensis,Paeonia suffruticosa,Rhus chinensis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Salmonella enterica)
• Monoamine Oxidase Isoenzymes: Genes, Functions and Targets for Behavior and Cancer Therapy (2018, NA)
• Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages (2018, NA)
• Molecular network and proposed mechanism of activity.Notes: (A) The predicted mechanism for the reversal of cell survival, angiogenesis, and inhibition of apoptosis (2018, NA)
• The miRNA-target genes involved in cancer signaling pathways (2018, Homo sapiens,Caenorhabditis elegans,Human T-cell leukemia virus type I)
• KEGG insulin signaling pathway identified by WebGestalt from the bta-miR-486 target gene list (2018, NA)
• Integrated transcriptomics and metabolomics pathway diagrams (2018, NA)
• Translocation and generation of toxic metabolites to the neuroglial circuitry mediating cognitive functions (2018, Escherichia coli,Helicobacter pylori,Clostridioides difficile,Bacteroides fragilis,Borreliella burgdorferi,Lacticaseibacillus casei,Lactobacillus acidophilus,Bifidobacterium longum,Lacticaseibacillus rhamnosus,Bacillus sp. in firmicutes,Lacticaseibacillus paracasei,Limosilactobacillus fermentum,Bifidobacterium bifidum,Lactobacillus helveticus,Eubacterium rectale,Lactobacillus sp.,Bacillus infantis,Empedobacter brevis,Clostridioides difficile CD68,Clostridioides difficile CD45,Clostridioides difficile CD21,Clostridioides difficile CD88,Zea mays,Candida dubliniensis,Triticum aestivum,Musa acuminata,Saccharomyces boulardii nom. inval.,Mus musculus,Rattus norvegicus,gut metagenome,Human alphaherpesvirus 1,Human immunodeficiency virus,human gut metagenome,Homo sapiens,Equus caballus,prion,NA)
• Metabolic regulation in GM-CSF-BMDCs (2018, Homo sapiens,Mus musculus)
• Autophagy as an anti-inflammatory process (2018, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Streptococcus pyogenes,Shigella flexneri,Mycolicibacterium smegmatis,Chlamydia trachomatis,Francisella tularensis,Legionella pneumophila,Streptococcus sp. group A,Mycobacterium leprae,Mycobacterium marinum,Coxiella burnetii,Anaplasma phagocytophilum,Yersinia pseudotuberculosis,Edwardsiella tarda,Yersinia pseudotuberculosis PB1,Human alphaherpesvirus 1,Vesicular stomatitis virus,Measles morbillivirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio,Leishmania mexicana,NA)
• Caspase-dependent apoptosis pathways in myofibroblasts (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Simplified diagram of transcriptional pathways and targets for intervention for AUD treatment (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Regulatory network of FSH to cervical cancer (2018, NA)
• Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells (2018, Lareunionomyces loeiensis,Melia azedarach,Homo sapiens,Mus musculus)
• Therapeutic approaches for cardiac regeneration and repair (2018, NA)
• Innate antiviral immune responses during viral infection (2018, unidentified influenza virus,Vesicular stomatitis virus,Enterovirus C,Human adenovirus 5,Foot-and-mouth disease virus,Bovine orthopneumovirus,Poliovirus 3,Foot-and-mouth disease virus A,Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis BCG str. China,Escherichia coli O6H16CFAII str. B2C,Escherichia coli WC1,Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Mus musculus,Cavia porcellus,Cricetus cricetus,Homo sapiens,Cheirogaleus major,Neospora caninum,NA)
• Foamy phagocyte polarization follows a triphasic pattern (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Mycobacterium tuberculosis,Candida dubliniensis,Ovis aries,unidentified influenza virus)
• Hypothalamic-pituitary-adrenal axis signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA,NA)
• MAPK pathway (2018, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Olea europaea)
• Schematic depiction of GDNF/RET/GFRA1 signaling in the ureteric bud (UB) tip during kidney development (2018, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Olea europaea)
• Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches (2018, Homo sapiens,Mus musculus,Helicobacter pylori,Adeno-associated virus)
• Calcium-calmodulin-calcineurn-NFaT-DYRK1A pathway to human beta cell proliferation (2018, NA)
• Metabolisms of SGG in seminiferous tubules: interrelationship between testicular germ cells and Sertoli cells (2018, NA)
• Cell cycle regulation pathway and the genes whose expressions were altered by 11-KT (2018, Danio rerio,teleost fish,Cyprinus carpio,Oryzias latipes,Carassius auratus,Dipnomorpha,Oreochromis niloticus,Serinus canaria,Carassius carassius,Oreochromis mossambicus,Sturnus vulgaris,Serinus sp.,Oncorhynchus nerka,Acanthopagrus schlegelii,Coryphopterus punctipectophorus,Syngnathus scovelli,Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Macaca mulatta,Sesamum indicum,Bacillus phage Gamma)
• PD-1 signal inhibits T-cell receptor (TCR) signaling pathway (2018, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human immunodeficiency virus,unidentified influenza virus,Murid betaherpesvirus 1,Homo sapiens,Pan troglodytes,Mus musculus,gut metagenome,Burkholderia pseudomallei,NA,NA)
• cAMP mediated intracellular signaling of A2 AdoR (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,Leishmania amazonensis)
• The molecular details of cytokine signaling via the JAK/STAT pathway (2018, NA)
• JAK/STAT pathway (2018, NA)
• Signaling pathways involved in the regulation of HSPs in bone metabolism (2018, NA)
• Gentisic acid attenuates cardiac hypertrophy and fibrosis through downregulation of the ERK1/2 pathway (2018, NA)
• Contributions of PCAF‐induced acetylation to the development of hepatocellular carcinoma and liver cancer tumour growth (2018, NA)
• Contributions of PCAF‐induced acetylation to the development of liver injury and mediators of inflammation (2018, NA)
• PCAF‐induced acetylation and hepatic Glucose homeostasis (2018, NA)
• Stimulation of autophagy by MAC in lung cancer cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Ascochyta viciae,Homo sapiens,Mus musculus,prion)
• Result of RNA-seq mainly involves the signaling pathway (2018, Glycyrrhiza uralensis,Trichoderma reesei,Prunus dulcis,Prunus armeniaca,Cinnamomum aromaticum,Ephedra sinica,Kadsura longipedunculata,Mus musculus,Rattus norvegicus,Homo sapiens)
• Targeting glycosaminoglycans to influence embryonic stem cell fate (2018, Homo sapiens,Mus musculus,Bos taurus)
• Treg suppression (2018, NA)
• CDK4/6, PARP and PI3K pathways inhibition by SMIs.(a) Inhibition of CDK4/6 by SMIs (e.g (2018, Homo sapiens,Mus musculus,Actitis hypoleucos,NA)
• Mechanisms mostly deemed to contribute to the development of APAs (2018, NA)
• Cell cycle pathway (the chart is from the KEGG database, gene symbolized by ★ and correlation P values can be found in ) (2018, NA)
• PPAR signaling pathway (2018, Danio rerio,Xenopus laevis,Oncorhynchus mykiss,Oryzias latipes,Salmo trutta,Oreochromis niloticus,Sparus aurata,Scophthalmus maximus,Pagrus pagrus,Oryzias melastigma,Oryzias javanicus,Mus musculus,Rattus norvegicus,Glycine max,Diaporthe sclerotioides,Homo sapiens)
• Graphical representation of IFNG signaling pathway (2018, Homo sapiens)
• Signaling reactions induced by thrombopoietin (2018, NA)
• Details of the SHH and Akt pathways (2018, NA)
• Pathway analysis within the identified metabolites in the (a) tocilizumab plus methotrexate, (b) tocilizumab, and (c) methotrexate strategy arms (2018, Homo sapiens,Rattus norvegicus)
• Engineered metabolic pathway for 3-HP production by S (2018, NA)
• Diagrammatic representation of occurrence of colorectal cancer (a) and various modulatory mechanisms of combinatorial administration of probiotics and celecoxib (b) in CRC with respect to different biomarkers (2018, Limosilactobacillus reuteri,Lactobacillus acidophilus,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Lactobacillus jensenii,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Zea mays,gut metagenome)
• Induction of oxidative stress by a virus infection and genome replication (2018, NA)
• Procoagulant properties of platelet CD36/ERK5 signaling (2018, Mus musculus,Candida dubliniensis,Homo sapiens)
• RTK-independent PI3KA/Akt/mTOR pathway leading to cell growth (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Panthera tigris,Homo sapiens,Lareunionomyces loeiensis)
• Integration of Drosophila and Human Genetics to understand Notch signaling related diseases (2018, Homo sapiens,Drosophila melanogaster)
• Ceramide pools and their metabolic connection (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury (2018, NA)
• mTORC2 in cell metabolism (2018, NA)
• Apoptosis pathways (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Streptococcus pyogenes,Bacillus anthracis,Francisella tularensis,Francisella tularensis subsp. novicida,Burkholderia thailandensis,Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,H1N1 subtype,Murid betaherpesvirus 1,Cowpox virus,Candida albicans,Aspergillus fumigatus,Paracoccidioides brasiliensis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Sus scrofa)
• Representative scheme of the presence of O-GlcNAcylation on glucose metabolism in skeletal muscle (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Xenopus laevis)
• Oncogenic signaling network activated by bile acids (2018, Mus musculus,Rattus norvegicus,Hordeum vulgare,Trigonella foenum-graecum,Homo sapiens)
• Bile acids initiating colorectal cancer development (2018, Mus musculus,Rattus norvegicus,Hordeum vulgare,Trigonella foenum-graecum,Homo sapiens)
• HBSP regulation on PI3K/Akt signaling to affect Fas-apoptotic pathway (2018, Homo sapiens,Hepatitis B virus)
• Schematic view of TF functions extracellular and intracellular signaling (2018, NA)
• Simplified PI3K-AKT pathway regulation of compounds in LP (2018, NA)
• Compounds and hitting targets on ICH (2018, NA)
• IL-13 signaling mechanisms in the treatment of ulcerative colitis (2018, Homo sapiens,Mus musculus,Bikinia letestui)
• Significant correlation of degree centrality between the OncoPPi BC network and our BC integrated network (p < 0.05), (r2 = 0.23688) (2018, NA)
• Communality network analysis for k-clique 9 (2018, NA)
• Cell signaling pathway regulated by MUC15 (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration (2018, NA)
• Novel protein signatures suggest progression to muscular invasiveness in bladder cancer (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Sequoia sempervirens,Mycobacterium tuberculosis variant bovis BCG)
• Effect of radiotherapy on DNA repair, mitochondrial function, cellular ROS, and EMT (2018, NA)
• Metabolic pathways involved in anticancer drug resistance (2018, NA)
• Metabolic pathways associated with cancer (2018, NA)
• Differentially expressed miRNA-mRNA pairs in nuclear factor of activated T cells (NFAT) cardiac hypertrophy pathway from NHE1 transgenic mouse hearts (2018, NA)
• Genes altered in NHE1 transgenic hearts were enriched in KEGG hypertrophic cardiomyopathy (HCM) pathway (2018, NA)
• Cross talk between the SphKs-S1P-S1PRs axis and the TGFB1signaling pathway in fibrosis (2018, NA)
• Snail and cell-cycle progression (2018, NA)
• miRNAs modulating dendrite morphogenesis converge (2018, NA)
• Models depicting the recruitment of BLM, FANCJ and other DNA repair proteins to double-strand breaks (2018, NA)
• Activation of the interferon-ɣ/STAT1 pathway (2018, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa domesticus,Homo sapiens,Salmonella enterica subsp. enterica serovar Abortusequi)
• Representative image of the anti-angiogenic potential of autophagy (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Bos taurus,Zika virus)
• Reconstructed metabolic pathways (KEGG) of S (2018, Scenedesmus quadricauda,Homo sapiens)
• Model summarizing current understanding of gonadotropin hormone receptor post-endocytic pathways and receptor signaling from VEEs (2018, NA)
• Current understanding of the mechanism of action of T-oligos (2018, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Molecular mechanisms of (-)-epigallocatechingallate (EGCG) suppressing the proliferation of cervical cancer cells (2018, Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Alphapapillomavirus 7,Human adenovirus 2,Nicotiana tabacum,Camellia sinensis,Theobroma cacao,Homo sapiens,Mus musculus,Streptomyces verticillus)
• Central carbon metabolism pathways in daf-2 and eat-2 mutants (2018, NA)
• Glycoengineering mAbs for enhanced sialylation and glycan-targeted ADC production (2018, NA)
• NCS-1 is a Regulator of Calcium Signaling in Health and Disease (2018, NA)
• Liver X Receptor (LXR) pathway as the result of the integration between transcriptomic and metabolomic data (2018, Homo sapiens)
• Breast cancer signaling pathway (2018, NA)
• Signaling mechanisms driving activity-dependent transcription of immediate early genes and late-response genes (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt signalling pathways (2018, NA)
• KMUP-1 on the adipocyte development in 3T3-L1 cells (2018, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Melatonin-mediated biotic stress response in plants (2018, NA)
• Pathway networks related to estrogen receptor alpha (2018, NA)
• Proposed signaling pathway triggered by kaempferol in EJ cells (2018, Nicotiana tabacum,Oryza sativa,herbal medicine,Fragaria x ananassa,Zingiber officinale,Psidium guajava,Hericium erinaceus,Lanxangia tsao-ko,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Arthrospira platensis)
• p38 MAPK or NLRP3 inflammasome pathway (2018, Caenorhabditis elegans,Nematostella vectensis,Hydra vulgaris,Hydra viridissima,Stichodactyla helianthus,Heteractis crispa,Actinia fragacea,Actinia equina,Carybdea rastonii,Phyllodiscus semoni,Chrysaora quinquecirrha,Alatina alata,Chiropsoides quadrigatus,Carukia barnesi,Pelagia noctiluca,Chironex fleckeri,Malo kingi,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Vibrio cholerae,Bacillus anthracis,Bacillus cereus,Neisseria gonorrhoeae,Salmonella enterica subsp. enterica serovar Typhi,Bacillus thuringiensis,Aeromonas hydrophila,Corynebacterium diphtheriae,Clostridium tetani,Vibrio cholerae non-O1non-O139,Clostridium septicum,Bacillus cereus C1L,Agaricus bisporus,Laetiporus sulphureus,Crassula alata,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Protobothrops flavoviridis,Bungarus multicinctus,Homo sapiens)
• Cartoon chart of mechanism of compound 2d against EV71 (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Raphanus sativus,Chlorocebus aethiops,Coxsackievirus B3,Enterovirus A71,Saururus chinensis,Sar)
• Mechanism by which TPAE attenuates H/R induced cardiomyocyte apoptosis by regulating NO production via activating the PI3K/Akt signaling pathway (2018, NA)
• Suggested mechanism of action of morusin in MDI-stimulated 3T3-L1 cells and primary adipocytes (2018, Armoracia rusticana,Morus alba,Schisandra chinensis,Sophora flavescens,Commelina communis,Morus australis,Morus alba var. multicaulis,Echinosophora koreensis,Morus mongolica,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Polyamine Pathway and Reaction Mechanism of DHS (2018, NA)
• Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models (2018, NA)
• Gene regulation network of 4 gene signature models (2018, Homo sapiens,Molva molva)
• Association network between microbiome and transcriptome (2018, NA)
• Glucocorticoids regulate NK cells and ILC1s functions upon MCMV infection (2018, NA)
• Circular RNA ITCH and 0043256 act as miRNA sponges to regulate the expression of ITCH (2018, Homo sapiens,Mus musculus,Rice yellow mottle virus)
• HMGB1 and Fas/FasL signal pathway in uveitis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Pseudomonas aeruginosa)
• HMBG1 and inflammatory and immune processes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Pseudomonas aeruginosa)
• Metabolic enzymes that characterize the progression from a normal liver to cirrhosis, which culminates in HCC (2018, NA)
• Mechanism by which TM contributes to eotaxin-2-mediated apoptosis in monocytic cells (2018, NA)
• EGFR signaling and generation of Treg and tol-DC (2018, Homo sapiens)
• Eicosanoid biosynthesis and PGE2 signaling via EP receptors (2018, Yersinia enterocolitica,Homo sapiens)
• Different levels of drug-drug interactions (2018, NA)
• The proposed mechanisms of over-activation of UPR to trigger apoptosis (2018, Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Simian endogenous retrovirus)
• Erdr1 Regulation and Downstream Pathways in CD4+ T Cells : Erdr1 suppression is regulated by the microbiota via TLR signaling in CD4+ T cells (2018, NA)
• DSB-free recombination-dependent replication.A (2018, NA)
• FMN-induced endothelium-dependent vasorelaxation via the PI3K/PTEN/Akt signaling pathway.Notes: FMN is absorbed into the endothelium and targeted PTEN leading to the phosphorylation of PI3K/Akt (2018, NA)
• Crosstalk of FGF10 during pancreatic cancer (2018, NA)
• DE genes on “Wnt Signaling Pathway and Pluripotency” pathway upon S (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Homo sapiens,Mus musculus,Influenza A virus)
• Summary of the potential treatments tested so far in EDMD (2018, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Caenorhabditis elegans,Pyrrhula pyrrhula)
• Nuclear envelope proteins and their potential roles in EDMD physiopathology (2018, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Caenorhabditis elegans,Pyrrhula pyrrhula)
• Canonical Wnt pathway and the role of the LRP6 receptor (2018, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Symphonia globulifera,Homo sapiens,Viana)
• Arthropod immune signaling pathways (2018, NA)
• Co-occurrence networks of diagnostic KOs involved in major energy and carbon fixation metabolic pathways in Llamara microbial mats from pond LLA9 (2018, metagenome,metagenomes,Homo sapiens)
• IL-32-induced signaling pathway activation in macrophages (2018, NA)
• Smad-dependent/independent transforming growth factor-beta signaling pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Potential mechanism underlying the role of PDE4 inhibitors in neuroplasticity after stroke (2018, NA)
• Hedgehog signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Paraechinus aethiopicus,Dicranocarpus parviflorus)
• Network generation of CDK1, YWHAZ and PRKDC based on significantly differential genes found between cells with PAX2 over-expression and those that lack that over-expression (2018, NA)
• Radiation and tyrosine kinase inhibitor resistance (2018, NA)
• Diminished inhibin B (INHBB) expression activates the transforming growth factor‐B (TGF‐B) pathway to promote anoikis resistance and migration (2018, NA)
• Transforming growth factor‐beta pathway and the Wnt/Beta‐catenin pathway (2018, NA)
• Positive feedback loop between the Rspo/Lgr5 pathway and the Wnt/B‐catenin pathway (2018, NA)
• Mouse breast carcinogenesis induced by the activation of the canonical Wnt pathway (2018, NA)
• Iron and inflammatory signaling to hepcidin (2018, NA)
• WNK pathway and major cancer-associated signaling pathways (2018, Homo sapiens)
• Akt/mTOR pathway and regulatory effects of galangin and pinocembrin on the phosphorylation of key proteins (2018, NA)
• Illustration of heterogeneous cancer death induced by dihydroartemisinin plus epirubicin liposomes through autophagy, apoptosis and necrosis (2018, Bos taurus,Capra hircus,Plasmodium falciparum,Plasmodium falciparum VS1,Homo sapiens,Mus musculus,Human betaherpesvirus 5,Pyrus communis)
• Sex-associated function of epithelial STAT3 signaling in K-ras mutant lung cancer (2018, NA)
• Schematic flow diagram of signal transmission from regulatory factors secreted by TM4 cells to ADSCs (2018, NA)
• SCAP/SREBPs Are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy (2018, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Gallus gallus,Human immunodeficiency virus 1,NA)
• Canonical FLT3 and mutant FLT3 signaling pathways (2018, Homo sapiens,Mus musculus)
• Trimethylamine N-Oxide: A Link among Diet, Gut Microbiota, Gene Regulation of Liver and Intestine Cholesterol Homeostasis and HDL Function (2018, gut metagenome,metagenome,human gut metagenome,human metagenome,Homo sapiens,Mus musculus,Candida dubliniensis)
• Anti-oxidative signaling and anti-apoptosis signaling pathways (2018, NA)
• Pharmacodynamic mechanism of TCM against HSV-1 (2018, NA)
• Regulation of PTPIP51 in melanoma (2018, NA)
• Regulation of PTPIP51 interactions in normal cells (represented by the HaCat cell line) (2018, NA)
• Host metabolism and cytokine induction (2018, Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Escherichia coli,Streptococcus pneumoniae,Bacillus anthracis,Vibrio vulnificus,Mus musculus,Rattus norvegicus,Homo sapiens,prion,human metagenome,NA,NA)
• Involvement of MAPKs in processes that lead to Parkinson’s disease pathology (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Allium sativum)
• Osteocalcin/ucOC and atheroprotective functions in vascular cells (2018, NA)
• Quantitative Proteomics Analysis of Lettuce (Lactuca sativa L.) Reveals Molecular Basis-Associated Auxin and Photosynthesis with Bolting Induced by High Temperature (2018, Lactuca sativa)
• Sonic Hedgehog (SHH) molecule or SHH secreted on extracellular vesicles (EVs) mediated functional improvement of endothelial progenitor cells (EPCs) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Paraechinus aethiopicus)
• Canonical and Non-Canonical Sonic hedgehog (SHH) signaling pathway in endothelial progenitor cells (EPCs) and endothelial cells (ECs) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Paraechinus aethiopicus)
• Putative anticancer effects of MTF exemplified by molecular and cellular key events (2018, Homo sapiens,Galega officinalis)
• Osteoclast precursor proliferation (2018, Mus musculus,Rattus norvegicus,Camellia sinensis,Hypericum perforatum,Homo sapiens,Mycobacterium tuberculosis H37Ra)
• Regulation of insulin clearance by CEACAM1-L (2018, NA)
• Select HCMV gene products that target apoptotic pathways during HCMV infection (2018, Human betaherpesvirus 5,Betapolyomavirus macacae,Murid betaherpesvirus 1,Human herpesvirus 5 strain AD169,Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Galatella linosyris)
• Luteolin and Toll-like receptor signaling pathway (2018, NA)
• Gene transcription pattern related to the TLR signaling pathway in white adipose tissue (2018, NA)
• Schematic diagram illustrating the proposed signaling pathway involved in S (2018, Mus musculus,Rattus norvegicus,Armoracia rusticana,Arachis hypogaea,Japanese encephalitis virus,Enterovirus A71,Homo sapiens,Staphylococcus aureus)
• Hepatitis C Virus (HCV)-induced oncogenic signaling (2018, NA)
• Canonical TGFB/SMAD signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• The mechanism of action of PIAS in the regulation of the STAT signaling pathway (2018, Drosophila melanogaster,Penaeus japonicus,Scylla paramamosain,Saccharomyces cerevisiae,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Vibrio anguillarum,Homo sapiens,Monocentris japonicus)
• Schemes of normoxic vs (2018, Mus musculus,Rattus norvegicus,Planiliza affinis,Chelon auratus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Schemes of normoxic vs (2018, Mus musculus,Rattus norvegicus,Planiliza affinis,Chelon auratus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Main effects on pathways in the metabolic syndrome hearts (DKO) versus WT hearts and for both mouse models the effect of ACE-I (2018, NA)
• Rho GTPase family signaling (2018, NA)
• Integrin linked kinase (ILK) signaling (2018, NA)
• Distribution of the targets of Shenzhu Capsule on the compressed TNF signaling pathway (2018, NA)
• The effect of C19 on the activation of KRAS4b and oncogenic KRAS4b signaling (2018, Homo sapiens,Mus musculus,Bos taurus,Leptospira kmetyi,Brosimum rubescens)
• Unfolded protein response pathways (2018, Homo sapiens,Mus musculus,Penicillium sp.)
• Resveratrol attenuated ROS-induced cognitive impairments in rats with Ang-II-induced early AD (2018, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• MAPK signaling pathway from KEGG database (2018, Homo sapiens,Citrus limon)
• Cytoprotective mechanisms of CAPE, CDDO-Im, curcumin and resveratrol (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Macaca mulatta,Curcuma longa,Bos taurus,Apis mellifera)
• Mechanism and role of 4PBA and YM155 (2018, NA)
• IFN-λ3 rescued the RIG-I signaling pathway (2018, NA)
• Topoisomerase 1 reaction and inhibitors (2018, NA)
• TAM receptor activation results in cell proliferation and survival that are essential for normal neural development (2018, NA)
• Natural compounds as anticancer agents in TNBCs: Mode(s) of Action (2018, NA)
• Ras pathway was hyperactivated in Sorafenib-resistant SKOV-3 cells (2018, NA)
• We observed that chlorogenic acid showed binding affinity to interact with ctDNA, VEGF and VEGF receptors (2018, Cucumis melo,Phoenix dactylifera,Peganum harmala,Elaeagnus angustifolia,Allium hirtifolium,Chrysobalanus icaco,Elaeagnus glabra,Quercus infectoria,Nepeta crispa,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,Opsanus beta,Leptospira kmetyi)
• Major pathways of cancer immunotherapy of Ganoderma in immune cells (2018, Panax ginseng,Agaricus bisporus,Ganoderma lucidum,Coccoloba uvifera,Ganoderma atrum,Ganoderma microsporum,Ganoderma sinense,Ganoderma lingzhi,Ganoderma applanatum,Ganoderma tsugae,Ganoderma formosanum,Ganoderma resinaceum,Mus musculus,Rattus norvegicus,Homo sapiens,Listeria monocytogenes,Molva molva,NA)
• Osteocyte role in MM bone disease (2018, NA)
• Potential mechanism of sodium butyrate on STZ-induced type 1 diabetes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome)
• Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential (2018, Bos taurus,Oryctolagus cuniculus,Equus caballus,Raphanus sativus,Euphorbia humifusa,Homo sapiens,Mus musculus)
• Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential (2018, Bos taurus,Oryctolagus cuniculus,Equus caballus,Raphanus sativus,Euphorbia humifusa,Homo sapiens,Mus musculus)
• Proteomic analysis of human prostate cancer PC-3M-1E8 cells and PC-3M-2B4 cells of same origin but with different metastatic potential (2018, Bos taurus,Oryctolagus cuniculus,Equus caballus,Raphanus sativus,Euphorbia humifusa,Homo sapiens,Mus musculus)
• Endogenous and exogenous metabolic pathways for butanol production in S (2018, Clostridium beijerinckii,Homo sapiens)
• Toll-like receptor signalling pathway shows similarities, but also differences between LPS and LPS + IFNG (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli)
• Roles of NRF2 in Modulating Cellular Iron Homeostasis (2018, NA)
• Mechanism of DQP on cardiac lipid and glucose metabolism (2018, NA)
• Mechanism of action of microtitre plate based complement activation assays (2018, Bos taurus,Oryctolagus cuniculus,Ovis aries,Rattus norvegicus,Cavia porcellus,Neisseria meningitidis,Sugarcane Ramu stunt disease phytoplasma,Homo sapiens,Lareunionomyces loeiensis)
• Mechanisms by which rLrp inhibits the production of LPS-induced cytokines (2018, Mycobacterium tuberculosis)
• Functional role of the novel phosphorylation site serine 811 (S811).The amino (N)-terminal domain of NCC contains several key phosphorylation sites (T55/T66) that are essential for NCC activity and plasma membrane abundance (2018, NA)
• Summary of the Interdependence of Klotho and Nutrient Sensing Pathways in the Face of Advancing Age and Nutrient Excess, and Strategies to Reverse Age-Related Arterial Phenotypes (2018, NA)
• Hallmarks of Vascular Aging (2018, NA)
• Modulators of Redox Metabolism in Head and Neck Cancer (2018, Homo sapiens)
• Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury (2018, Homo sapiens)
• Interconnected responsible pathways to cause amyloid and tau accumulation (2018, NA)
• Ban-Xia-Xie-Xin-Tang on TNF signaling pathway (2018, herbal medicine,Panax ginseng,Zingiber officinale,Scutellaria baicalensis,Melia azedarach,Ziziphus jujuba,Coptis chinensis,Pinellia ternata,Syzygium cumini,Mus musculus,Rattus norvegicus,Homo sapiens,H1N1 subtype)
• Brief diagram of amino acid metabolism pathways with related DEGs and DAMs (2018, NA)
• Diagram of carbohydrate metabolism pathways with their related DEGs (differentially expressed genes) and DAMs (2018, NA)
• Oxidative stress-induced apoptosis (2018, NA)
• Model showing possible mechanism for regulation of ovarian development by four key miRNA/gene pairs (2018, NA)
• Complement activation pathway and regulation (2018, NA)
• Scheme summarizing the inhibition of cisplatin-induced nephrotoxicity by maltol via the down-regulation of AMPK through PI3K/Akt pathway (2018, Armoracia rusticana,Glycine max,Panax ginseng,Cichorium intybus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Fibroblast of Growth Factor (FGF) signaling activation and regulation (2018, NA)
• Rho Kinase Involved Metabolic Pathway (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Oryctolagus cuniculus)
• Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats (2018, NA)
• Integration of oncogenic KRAS signaling by MYC in PDECs (2018, Mus musculus,Homo sapiens)
• The Potential Schematic Diagram of the Effects of CPE on the Beta Cell and Liver Tissue (2018, NA)
• GC-C activation, intracellular effects (2018, NA)
• Enzymatic complexes across scales (2018, Drosophila melanogaster,Caenorhabditis elegans,Trypanosoma brucei,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus,Rhodococcus rhodochrous)
• TRAFs in canonical and non-canonical NFKB signaling pathways (2018, NA)
• Role of TRAFs in TCR-, costimulatory receptor-, and cytokine receptor-associated signaling pathways controlling TFH differentiation (2018, NA)
• Pathway model of high temperature stress responses in U (2018, NA)
• Tumor-induced CD8+ Treg cells and their potential role in tumor microenvironment (2018, NA)
• Leptin activates multiple signaling pathways (2018, NA)
• Cellular oxidative and genotoxic stress responses converge on the AMPK/mTORC1 pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Human immunodeficiency virus 1,unidentified,Dipturus trachyderma)
• Regulation and downstream effects of the Akt signaling pathway (2018, NA)
• Activation of EGFR/PI3K/Akt signaling pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Helicobacter pylori,Mesomycoplasma hyorhinis,Homo sapiens,Mus musculus,Armoracia rusticana)
• Schema of deriving corneal cell phenotype from iPSCs (2018, Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,NA)
• IL-1B signaling pathway in CXCR3-mediated MSC transendothelial migration (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Human alphaherpesvirus 2,Homo sapiens)
• Proposed model of airway tolerance (2018, NA)
• Gene networks (2018, Homo sapiens)
• Schematic depiction of proposal mechanism by which AF confers anticancer actions in TamR breast cancer cells (2018, NA)
• Structure of hRLX2, hypothetical pathway intermediates of RXFP1/2 and the benefits of hRLX2 therapy in radiation cystitis (2018, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• The TGFB/BAMBI pathway (2018, Homo sapiens,Mus musculus,Bos taurus,Nicotiana tabacum)
• The mechanisms involved in the maintenance of b[Ca2+]i (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Cavia porcellus,Homo sapiens)
• Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NFKB signaling pathway (2018, NA)
• Proteomic analysis of Lactobacillus casei GCRL163 cell-free extracts reveals a SecB homolog and other biomarkers of prolonged heat stress (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Bacillus subtilis,Escherichia coli K-12,Bacillus subtilis At2,Lactiplantibacillus plantarum,Haemophilus influenzae,Lacticaseibacillus casei,Lactobacillus acidophilus,Lacticaseibacillus rhamnosus,Bacillus thuringiensis,Lacticaseibacillus rhamnosus GG,Bacillus licheniformis,Streptococcus thermophilus,Lacticaseibacillus paracasei,Limosilactobacillus fermentum,Lactobacillus delbrueckii subsp. bulgaricus,Lactobacillus helveticus,Lacticaseibacillus casei str. Zhang,Oenococcus oeni,Streptococcus oralis,Lactiplantibacillus plantarum subsp. plantarum,Escherichia coli O157H7 str. Sakai,Bifidobacterium breve UCC2003,Lacticaseibacillus paracasei subsp. paracasei,Listeria monocytogenes str. Scott A,Lacticaseibacillus paracasei ATCC 334,Brevibacillus borstelensis,Helicobacter pylori NAD1,Bacillus licheniformis CG-B52,Bacillus sp. CC120222-01,Homo sapiens,Rattus norvegicus,Carpotroche brasiliensis)
• Overview scheme of the PD risk factor genes and the molecular pathway where they are involved (2018, NA)
• EphrinB/EphB forward signaling activation-induced TNFA production (2018, NA)
• Proposed model of 25HC preventing LPS‐induced TLR4 signalling pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Vesicular stomatitis virus,Zika virus,Ebola virus,Mus musculus,Rattus norvegicus,Staphylococcus aureus,Escherichia coli O111B4,Homo sapiens,Armoracia rusticana)
• Understanding psoriasis: Role of miRNAs (2018, Homo sapiens,Mus musculus)
• Rag-independent Gln stimulation of mTORC1 via PLD-derived PA (2018, NA)
• Rapid EGFR testing approach (2018, Homo sapiens,Zingiber officinale,Falco peregrinus)
• Indian hedgehog homolog signaling pathway (2018, Bos taurus,Lareunionomyces loeiensis,Equus asinus,Sesamum indicum,Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• Regulatory effects of lncRNAs and miRNAs on autophagy in malignant tumorigenesis (2018, Homo sapiens,Saccharomyces cerevisiae)
• Enhancement of cutaneous wound healing by Dsg2 augmentation of uPAR secretion (2018, Homo sapiens,Mus musculus)
• Phospholipid-binding tumor suppressor ANXA7 linked to the interrelated FGF8 and cyclin E pathways through Ca/phospholipid signaling in prostate cancer (2018, NA)
• PD-1 signaling pathway (2018, NA)
• Mechanisms of resistance to BRAF and MEK inhibitors and clinical update of US Food and Drug Administration-approved targeted therapy in advanced melanoma (2018, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• HIF-1A, STAT3, NO, and miRNA in VEGF expression.Notes: STAT3 and HIF-1A promote VEGF expression (2018, NA)
• Main signalling pathways coordinating the diversity of vessel formation processes (2018, NA)
• Dopaminergic synapse signaling pathway, with the enriched target genes highlighted in red (2018, NA)
• GABAergic synapse signaling pathway, with the enriched target genes highlighted in red (2018, NA)
• Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis (2018, NA)
• Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis (2018, NA)
• MAPK and PI3K signaling pathways (2018, NA)
• Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis (2018, NA)
• Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A (2018, NA)
• Hypothetical model to sensitize GC (2018, Homo sapiens,Oryctolagus cuniculus,vectors,Calloplesiops altivelis)
• The Wnt/Beta-catenin and other signaling pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• (Left) In the “off” state, Beta-catenin binds with glycogen synthase kinase 3B (GSK3B), axin2, adenomatous colon polyposis protein (APC), and casein kinase-1 (CK- 1) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Ubiquitin modifications in the WNT/Beta-catenin pathway (2018, NA)
• Ubiquitin modifications in the TGFB pathway (2018, NA)
• Characterization of the miRNA regulators of the human ovulatory cascade (2018, Bos taurus,Sus scrofa,Ovis aries,Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• miRNA-regulated pathways in preovulatory granulosa cells (2018, Bos taurus,Sus scrofa,Ovis aries,Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• TEdeff-induced immunotherapy resistance (2018, NA)
• Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk (2018, NA)
• Key cellular and molecular pathways regulating blood-brain barrier integrity (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• ARG1-arginine-immune suppression-fatigue pathway (2018, Homo sapiens,Mus musculus,Salmonella enterica subsp. enterica serovar Typhimurium,Celithemis elisa)
• Hypothetic schematic model of the underlying mechanisms of targeting G9a to suppress NSCLC (2018, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Possible therapeutic strategies for cancer stem cell elimination (2018, Homo sapiens,Macaca mulatta,Callithrix jacchus,marmosets,Mus musculus,Oryctolagus cuniculus,Diaporthe sclerotioides,Macrostomum sp.)
• Proposed mechanisms by which PKM2‐mTORC1 regulatory pathways contribute to resistance in RCC cells (2018, NA)
• Interactions and functions of NRPs (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Citrus macrophylla)
• Hypothetical scheme for the unfolded protein response-induced signaling cascade in MANF-deficient beta cells (2018, Homo sapiens,Mus musculus)
• Scheme depicting the main upstream and downstream regulators of mTORC1 signaling pathway (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• RHBDF1-facilitated membrane trafficking of pro-TGFA via CCV pathway (2018, NA)
• Snapshot of protein-protein interactions involving p85A (the “p85A network”).The binding to PTEN and to BRD7-XBP1 has a negative effect on PI3K activity (red color), the first by stabilizing PTEN, the second via p85A depletion (, , –) (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Influenza A virus)
• Possible signaling mechanisms of SERM actions in neurocognition and neuroprotection (2018, NA)
• Proposed pathways for inducing SR Ca2+ leak during Beta-adrenergic signaling and stretch in a ventricular cardiomyocyte (2018, NA)
• Infection and immunity in atherogenesis (2018, NA)
• Mercapturic Acid Pathway (2018, Arabidopsis thaliana,Armoracia rusticana,Nicotiana tabacum,Solanum lycopersicum,Solanum tuberosum,Brassica oleracea,Daucus carota,Raphanus sativus,Musa acuminata,Citrus macrophylla,Persea americana,Cinchona pubescens,Brassica rapa subsp. rapa,Nasturtium officinale,Brassica rapa subsp. chinensis,Brassica oleracea var. italica,Eruca vesicaria subsp. sativa,Mus musculus,Rattus norvegicus,Trichoplusia ni,Schistosoma haematobium,Homo sapiens,gut metagenome,Equus caballus,Geositta cunicularia)
• Expression and regulation of hepcidin in brain cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Network of the two sets of top genes with P-value < 0.01 in the case–control and family-based analyses focusing on rare, deleterious variants (2018, Homo sapiens)
• PTEN/PI3K/AKT pathway (2018, herbal medicine,Morinda citrifolia,Trollius chinensis,Chromolaena odorata,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Lipid synthesis pathway in porcine mammary gland (2018, Zea mays,Candida dubliniensis,Lareunionomyces loeiensis,Olea europaea,Helianthus annuus,Bos taurus,Canis lupus familiaris,Capra hircus,Sus scrofa,Homo sapiens,Rattus norvegicus,Escherichia coli,Pieris brassicae,Ctenopharyngodon idella)
• Milk protein synthesis pathway in porcine mammary gland (2018, Zea mays,Candida dubliniensis,Lareunionomyces loeiensis,Olea europaea,Helianthus annuus,Bos taurus,Canis lupus familiaris,Capra hircus,Sus scrofa,Homo sapiens,Rattus norvegicus,Escherichia coli,Pieris brassicae,Ctenopharyngodon idella)
• Diverse Actions of Estradiol on Anorexigenic and Orexigenic Hypothalamic Arcuate Neurons (2018, NA)
• IGF signaling in the placenta (2018, NA)
• AKT/mTOR Signalling Pathway (2018, NA)
• Combined BRAF and HSP90 inhibition in patients with unresectable BRAF V600E mutant melanoma (2018, Homo sapiens,Mus musculus,Panthera leo)
• Terpenoids biosynthesis pathway (A), and pathway engineering strategies (B,C) (2018, Escherichia coli,Homo sapiens)
• ZnO NPs-induced neuroinflammation (2018, NA)
• mGluR1 modulation of the mGluR6‐TrpM1 complex (2018, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Ambystoma tigrinum)
• TLR and CLR interactions with helminth-derived products (2018, NA)
• Schematic diagram illustrating D1R and NMDAR signaling cascades in heterozygous Nf1 mice (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Origins of centromeric breaks (2018, NA)
• Signaling pathways and regulatory nodes that indicate novel therapeutic approaches for KRAS mutant NSCLC (2018, NA)
• Metabolic reprogramming of the tumor microenvironment by p62 and its partners (2018, Homo sapiens,Mus musculus,Nicotiana tabacum,Salmonella enterica subsp. enterica serovar Typhimurium)
• Genotype-driven metabolic reprogramming in cancer (2018, NA)
• Involvement of mitophagy in the transportation of amorphous calcium phosphate (ACP) precursors from the mitochondria to the extracellular matrix in stem cells with osteogenic potential (2018, NA)
• Cardioprotection by AsIV through CaSR/IP3R pathway (2018, NA)
• Canonical NFKB pathway (2018, Homo sapiens,Mus musculus)
• Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches (2018, Mouse mammary tumor virus,Moloney murine leukemia virus,Homo sapiens,Mus musculus,Sequoia sempervirens)
• GPR108 works as a dual functional regulator to balance the TLR-triggered immune response (2018, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Oryza sativa,Capra hircus,Vasconcellea candicans,Homo sapiens,Mus musculus,vectors)
• Transcriptome analysis of an incompatible Persea americana-Phytophthora cinnamomi interaction reveals the involvement of SA- and JA-pathways in a successful defense response (2018, Persea americana,Phytophthora cinnamomi)
• Proteomics and phosphoproteomics driven identification of the aberrant regulation of signalling pathways leading to poor patient survival (2018, NA)
• Functional analysis of genes differentially expressed in response to L-lactate after 1 h (2018, NA)
• Hemoglobin production and redox homeostasis in erythrocytes (2018, NA)
• Activin A/Smad signaling pathway (2018, NA)
• Differentially regulated genes by IRF7 overexpression upon H6N2 infection (2018, Influenza A virus,unidentified influenza virus,H5N1 subtype,H6N2 subtype,H5N2 subtype,H5N8 subtype,H10N7 subtype,Bos taurus,Canis lupus familiaris,Equus caballus,Gallus gallus,Meleagris gallopavo,Homo sapiens,Mus musculus,NA)
• DNA hypermethylation, histone demethylases and histone deacetylases effect on the metabolic enzymes expression involved in glycolysis and glutaminolysis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Theoretical background for an interaction between cyclooxygenase and the renin-angiotensin-aldosterone systems (2018, NA)
• Map of autophagy induction (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Tumor-related methods of immune-escape (2018, NA)
• O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway cross-dysregulation in human chronic diseases (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops)
• Complex interplay between O-GlcNAcylation and PI3K/AKT/mTOR signaling pathway controls numerous biological processes (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops)
• Structures of Vitamin K and biosynthesis in green plastids (2018, Chlamydomonas reinhardtii,Cyanophora paradoxa,Homo sapiens)
• The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Triticum aestivum,Homo sapiens,Mus musculus,Dipturus trachyderma)
• C/EBPB deletion in oncogenic Ras skin tumors is a synthetic lethal event (2018, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Zea mays,Staphylococcus aureus,Enterovirus C,Parthenos sylvia)
• Proposed model of irisin effects on pancreatic cancer (2018, NA)
• Arid5a in the IL-17R signaling pathway (2018, NA)
• Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder (2018, NA)
• RNA-seq analysis revealed that LECs exhibit a highly perturbed cytokine–cytokine receptor pathway at 24 hours PCS (2018, Homo sapiens,Mus musculus,Bikinia letestui)
• Pathological mechanism of low‐molecular‐mass hyaluronan (LMMHA) (200 000 MW) induces pulmonary inflammation in bronchoalveolar lavage fluid (BALF) neutrophils (2018, NA)
• Ginsenoside Rh2 epigenetically affects genes in the cell-mediated immune response pathway (2018, NA)
• Mammalian autophagy-lysosomal pathway (ALP) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,prion)
• BAFFR-induced intracellular signaling (2018, unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Mus musculus,Streptococcus pneumoniae)
• Schematic diagram showing both the pathway for VEGF upregulation though EGFR/ALK gene alteration and its immunosuppressive role (2018, NA)
• Schema of sortilin regulating EGFR trafficking () (2018, NA)
• BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis (2018, Homo sapiens,Mus musculus)
• YAP/TAZ upstream signals and downstream responses (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Human gammaherpesvirus 8,Oryzias latipes,NA)
• Rheumatoid arthritis associated transcriptional changes on osteoclast differentiation network in the synovium (2018, Homo sapiens,Mus musculus,Corynephage beta)
• In this figure, we consider potential mechanisms regulated by physical activity and caloric restriction in inhibiting the mTOR pathway (2018, NA)
• Beneficial effect of RC on hepatic glucose and lipid metabolism signalling pathways (2018, Mus musculus,Rattus norvegicus,Zea mays,Brassica oleracea,Homo sapiens,Oryctolagus cuniculus,Opsanus beta)
• Regulatory network analysis of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA (2018, Hepatitis B virus,Influenza A virus,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,H1N1 subtype,Semliki Forest virus,Porcine epidemic diarrhea virus,Transmissible gastroenteritis virus,Sapelovirus A,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Armoracia rusticana,NA)
• Simplified PI3K Signaling Cascade and Known Clinical Disorders Caused by Genetic Pathway Activation (2018, NA)
• GSK-3 regulated signaling pathways and splicing factor phosphorylation (2018, Mus musculus,Drosophila melanogaster,Cavia porcellus,Dictyostelium discoideum,Homo sapiens,Lily symptomless virus)
• Magnetic fields affects microtubules via EGFR and calcium pathways (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Cryptotis parvus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• The signal transduction pathway activated by PND in PC12 cells.The proposed PND-activated cAMP-Epac1-Erk-CREB pathway is shown in the red arrow-connected cascade (2018, Armoracia rusticana,Panax ginseng,Daucus carota,Panax notoginseng,Bos taurus,Equus caballus,Homo sapiens,Rattus norvegicus)
• Role of the GAlpha-cAMP/PKA signaling pathway in regulating the production of extracellular-degrading enzymes in C (2018, Chaetomium globosum,Homo sapiens)
• Cell intrinsic dysregulation of innate immune signaling in MDS HSCs (2018, NA)
• Protein based pathway mapping of the patient response in the serum to antibiotic treatment (2018, NA)
• Suggested Schemes for PGI1-Mediated Biosynthesis of MEP Pathway Isoprenoid-Derived CKs and GAs in Cells of Vascular Tissues, and FAs and Proteins in Mixotrophic Maturing Embryos of Arabidopsis (2018, NA)
• Three key innate immune pathways for the most common retinal degenerative diseases (2018, NA)
• Negative effects of resveratrol on NFKB via several pathways in SCI (2018, Saccharomyces cerevisiae,Vitis vinifera,Arachis hypogaea,Polygonum cuspidatum,Veratrum grandiflorum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Nuclear factor erythroid 2-related factor 2 (NRF2) activation (2018, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Saccharomyces cerevisiae,Bos taurus,Capra hircus,Ovis aries,Brassica oleracea,Cinchona pubescens,Homo sapiens,prion)
• Proposed model for the roles of miR-494-3p in mitochondrial biogenesis and thermogenesis in beige adipocytes (2018, NA)
• Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression (2018, Homo sapiens,Mus musculus,Bos taurus,Cystobasidium portillonense)
• Mechanisms by which IFNA disrupts thyrocytes to trigger AITDs (2018, Homo sapiens)
• Nutrient availability affects cellular response to stress signals (2018, Homo sapiens,Bos taurus,Armoracia rusticana)
• Molecular features of the JAK-STAT signaling pathway (2018, Respiratory syncytial virus,Human alphaherpesvirus 3,Homo sapiens,Mus musculus,Canis lupus familiaris,Citrobacter rodentium)
• Metastatic adrenocortical carcinoma (2018, NA)
• Scheme showing a possible mechanism of the alleviated TLR-mediated inflammatory responses of macrophage U937 cells to the mycobacterial infection by coinfected A549 epithelial cells (2018, NA)
• Pathway analysis shows apolipoprotein E along with its respective interactions in Parkinson’s disease and schizophrenia pathway (2018, NA)
• Calcium‐sensing receptor signalling and trafficking (2018, Homo sapiens,Mus musculus)
• Schematic illustrations of identified pathways in hepatitis C virus-induced liver carcinogenesis (2018, Hepatitis B virus,Hepatitis C virus genotype 3,Homo sapiens,Rattus norvegicus,Wisteria floribunda,NA)
• Schematic model for phosphorylation-dependent YAP translocation by DVL (2018, NA)
• Dengue virus and the host innate immune response (2018, Dengue virus,Homo sapiens)
• Dengue virus and the host innate immune response (2018, Dengue virus,Homo sapiens)
• Dengue virus and the host innate immune response (2018, Dengue virus,Homo sapiens)
• Innate immune response to DENV infection (2018, Dengue virus,Homo sapiens)
• Proposing a mechanism for VPA, linking epilepsy and bipolar disorder with the phosphoinositide salvage pathway (2018, NA)
• Multiple phases and regulation of cilium assembly (2018, NA)
• Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer (2018, Glycine max,Malus domestica,Arachis hypogaea,Pyrus communis,Scutellaria baicalensis,Tripterygium wilfordii,Taxus brevifolia,Colletotrichum gloeosporioides,Veratrum californicum,Penicillium sp.,Camptotheca acuminata,Terminalia chebula,Talaromyces funiculosus,Ganoderma lingzhi,Celastrus orbiculatus,Hypericum japonicum,Inula japonica,Handroanthus impetiginosus,Streptomyces hygroscopicus,Bacillus sp. B31,Homo sapiens,Mus musculus,Gallus gallus)
• Therapeutic targeting of oncogenic transcription factors by natural products in eye cancer (2018, Glycine max,Malus domestica,Arachis hypogaea,Pyrus communis,Scutellaria baicalensis,Tripterygium wilfordii,Taxus brevifolia,Colletotrichum gloeosporioides,Veratrum californicum,Penicillium sp.,Camptotheca acuminata,Terminalia chebula,Talaromyces funiculosus,Ganoderma lingzhi,Celastrus orbiculatus,Hypericum japonicum,Inula japonica,Handroanthus impetiginosus,Streptomyces hygroscopicus,Bacillus sp. B31,Homo sapiens,Mus musculus,Gallus gallus)
• KEGG pathway suggested that various targets in p53 signaling were tightly associated with ADQ pharmacological action (2018, NA)
• Schematic outline of the intracellular signalization in the retinohypothalamic tract (2018, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Homo sapiens,NA)
• Liver kinase B1 signaling during neurite development (2018, NA)
• Metabolome analyses of wild-type and mutants plants (2018, NA)
• Proposed positive feedback mechanism for Th17 cell-secreted IL-17A and NLRP3 inflammasome activity in a circuit (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Wedelia chinensis)
• Evolutionarily selected pathway (ESP) map (2018, Homo sapiens)
• Mechanism of pyruvate pathway regulation in different culture conditions of Pichia pastoris producing antibody fragment scFv anti-LDL(−) (2018, Saccharomyces cerevisiae,Arabidopsis thaliana,Komagataella pastoris,Komagataella phaffii GS115,Ogataea methanolica,Homo sapiens,prion)
• TRPCing around the Hypothalamus (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Cavia magna,Homo sapiens)
• Schematic Illustrating Potential Pathways for Glucose Utilization and Energy Production by Tendon Cells (2018, NA)
• Phosphoproteomic pathway analysis of heat stress induced MET signaling (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Bikinia letestui)
• Brain‐derived neurotrophic factor (BDNF)/tropomyosin kinase receptor B (TrkB) pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Felis catus)
• Colon Epithelial MicroRNA Network in Fatty Liver (2018, NA)
• Exosomes can regenerate stem cell phenotypes and convert them to CSCs by regulating the Hedgehog pathway (2018, NA)
• Exosomes can regenerate stem cell phenotypes and convert them to CSCs by regulating the Notch pathway (2018, NA)
• Exosomes can regenerate stem cell phenotypes and convert them to CSCs by regulating the Wnt pathway (2018, NA)
• Action of xanthine derivatives as inhibitor for regulating the catalytic action of PDEs in signal transduction pathway (2018, PX clade,Camellia sinensis,Theobroma cacao,Coffea arabica,Staphylococcus aureus,Pseudomonas aeruginosa,Pseudomonas alcaligenes,Rattus norvegicus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus)
• Crosstalk of bone cells within bone marrow regulates bone remodeling, adipogenesis, hematopoiesis, and angiogenesis (2018, Homo sapiens,Mus musculus)
• Genomic mechanisms of immune evasion in colorectal cancer: from discovery to clinical practice (2018, Homo sapiens)
• Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Poxviruses evade cytosolic sensing through disruption of an mTORC1-mTORC2 regulatory circuit (2018, NA)
• Metabolite-dependent mechanisms that influence muscle fiber composition (2018, Homo sapiens,Mus musculus,Coregonus peled)
• Gene network analysis of DE genes in the infected group (2018, NA)
• Translation acrobatics: how cancer cells exploit alternate modes of translational initiation (2018, NA)
• P38 MAPK signaling pathway in the regulation of the NLRP3 inflammasome and macrophage pyroptosis (2018, NA)
• Sub-networks constructed based on the differentially expressed genes identified in the communities of interest in the protein-protein interaction network using CFinder software (2018, Homo sapiens,Mus musculus,Orientia tsutsugamushi,NA)
• PPI network based on the interaction of the differentially expressed genes between the M2 and M0 groups (2018, Homo sapiens,Mus musculus,Orientia tsutsugamushi,NA)
• PPI network constructed based on the genes with differential expression between the M2 and M0 groups in the intersection of GSE18686 and GSE35449 (2018, Homo sapiens,Mus musculus,Orientia tsutsugamushi,NA)
• Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity (2018, NA)
• Fibroblast growth factor receptor (FGFR) structure, FGFR signaling, and specificity of the FGF–FGFR interaction (2018, Homo sapiens,Macaca fascicularis,Mus musculus,Gallus gallus,NA)
• miR-451-AMPK-mTOR-cell cycle signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Dictyostelium discoideum,Taraxacum officinale,Axis axis)
• Proposed mechanisms underlying enteroendocrine secretion in response to T2R agonists (2018, herbal medicine,Fragaria x ananassa,Theobroma cacao,Momordica charantia,Gentiana lutea,Gentiana scabra,Hoodia gordonii,Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathway with PLD1 participation was activated in LNCaP cells in the androgen-free environment (2018, NA)
• Nutrient stress and insulin resistance (2018, NA)
• Insulin resistance-mediated mechanisms in LECs (2018, NA)
• Pro-apoptotic signaling pathway induced by orexins (2018, NA)
• Central role of hepcidin in regulation of iron metabolism (2018, NA)
• MAPK pathway leading to activation of Hog1 in S (2018, Yarrowia lipolytica,Homo sapiens)
• The role of Piezo1 and Gq/G11 proteins in endothelial response to different flow patterns (2018, Homo sapiens,Mus musculus)
• Differential targeting of genes in the drug metabolism pathway (2018, NA)
• Signaling via the ALX/FPR2 receptor (2018, NA)
• CARD14/CARMA2 variants in keratinocytes (2018, NA)
• PI3KD activation in B- and T-cells during class-switch recombination (2018, Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Haemophilus influenzae,Moraxella catarrhalis,Pseudomonas aeruginosa MSH3,Homo sapiens,Mus musculus,Cryptosporidium parvum)
• Regulatory mechanisms that control the switch from PKM1 to PKM2 (2018, NA)
• Wnt signaling and Alzheimer’s pathology (2018, NA)
• Putative molecular effects of MSC-secretome on latency-reactivation from tissue HIV-1 reservoirs (2018, NA)
• Proposed mechanistic model of KMT2D in prostate cancer (2018, Homo sapiens,Macaca mulatta,Pan troglodytes,Mus musculus)
• In this illustration, potential mechanisms of tumor cell survival via crosstalk between components of the MET pathway, glycolysis, and autophagy are depicted (2018, NA)
• Nanoparticulate TiO2-mediated inhibition of testosterone production via the ERK1/2–PKA–PKC signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma)
• Schematic model of the mechanism of miR-218 in PTC.Abbreviation: PTC, papillary thyroid cancer (2018, NA)
• Insulin regulation of major metabolic responses in the cells (2018, Protorhus longifolia,Homo sapiens)
• Key roles of menin in mTOR signaling (2018, NA)
• cbi-cob-hem gene clusters of L (2018, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Lactiplantibacillus plantarum,Limosilactobacillus reuteri,Priestia megaterium,Propionibacterium freudenreichii,Listeria innocua,Loigolactobacillus coryniformis,Furfurilactobacillus rossiae DSM 15814,Furfurilactobacillus rossiae,Homo sapiens,Mus musculus)
• Cellar signal transduction pathway induced by GALT (2018, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Bacillus subtilis At2,Haemophilus influenzae,Escherichia coli BL21,Lacticaseibacillus casei,Escherichia coli O157H7,Cutibacterium acnes,Pasteurella multocida,Lactobacillus helveticus,Streptococcus suis,Actinobacillus pleuropneumoniae,Shigella sonnei,Lacticaseibacillus casei str. Zhang,Vibrio cholerae O1 biovar El Tor,Mannheimia haemolytica,Haemophilus parahaemolyticus,Rodentibacter pneumotropicus,Klebsiella pneumoniae CG43,Lactococcus raffinolactis,Erwinia amylovora ATCC BAA-2158,Gallibacterium anatis,Bos taurus,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana,Respiratory syncytial virus,Punavirus P1)
• TGFB signaling pathway in melanoma (2018, Homo sapiens)
• Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy (2018, Homo sapiens)
• Canonical and non-canonical NFKB signaling pathways (2018, Homo sapiens)
• Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy (2018, Homo sapiens)
• PI3K-Akt pathway activity in melanoma (2018, Homo sapiens)
• PI3K-Akt pathway activity (2018, Homo sapiens)
• Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy (2018, Homo sapiens)
• Pathogenic roles of NLRP3 inflammasome in liver diseases (2018, Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Chromobacterium violaceum,Hepatitis B virus,Murine hepatitis virus,Homo sapiens,Mus musculus,Trypanosoma cruzi,NA)
• Detailed diagram for fatty acid and phospholipid synthesis in C (2018, Staphylococcus aureus,Homo sapiens)
• Prominent changes upon ageing in the central carbon metabolism (2018, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides)
• IRAK4 and MyD88-dependent TLR signaling (2018, NA)
• Pro-tumorigenic functions of GPNMB (2018, NA)
• Phospholipase D signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs (2018, NA)
• Insulin signalling KEGG pathway indicating up‐ and down‐regulated differentially expressed genes in livers of male and female MO‐F1 vs (2018, NA)
• Nucleotide metabolism pathway (2018, NA)
• Glucose metabolism pathway (2018, NA)
• Drug selectivity (2018, NA)
• Schematic showing PDK4 as a checkpoint in NFKB/TNF-mediated apoptosis (2018, NA)
• The sugar metabolism (green) and signaling (blue) pathways (2018, NA)
• The BMPR2 signaling pathway illustrating the potential canonical (green) and noncanonical (grey, blue) targets that can be activated (2018, NA)
• Consequences of endoplasmic reticulum stress response pathway (2018, NA)
• Hedgehog (Hh) pathway activation (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Nicotiana tabacum,Paraechinus aethiopicus)
• Induction of innate immune response by viral infection (2018, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human papillomavirus,unidentified influenza virus,Vesicular stomatitis virus,Murine hepatitis virus,Lyssavirus rabies,Modified Vaccinia Ankara virus,Human endogenous retrovirus,Autographa californica nucleopolyhedrovirus,Bombyx mori nucleopolyhedrovirus,Autographa californica multiple nucleopolyhedrovirus,unidentified nuclear polyhedrosis viruses,Orgyia pseudotsugata multiple nucleopolyhedrovirus,Spodoptera exigua multiple nucleopolyhedrovirus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Bombyx mori,Spodoptera frugiperda,Autographa californica,Homo sapiens,Escherichia coli,vectors,NA)
• Suggested mechanistic pathway of different flavonoids in the activation of non-shivering thermogenesis in BAT and WAT (2018, Candida dubliniensis,PX clade,Malus domestica,Olea europaea,Camellia sinensis,Brassica oleracea,Allium cepa,Theobroma cacao,Daucus carota,Solanum melongena,Citrus x paradisi,Petroselinum crispum,Citrus sinensis,Salvia rosmarinus,Apium graveolens Dulce Group,Thymus vulgaris,Fagopyrum esculentum,Origanum vulgare,Vaccinium myrtillus,Trifolium pratense,Mentha x piperita,Citrus unshiu,Gelidium amansii,Gelidium elegans,Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,Opsanus beta,Hippospongia communis)
• 1,25(OH)2D3 acts mediating lipid signalling pathways (protein kinase C pathway), phosphatidylinositol-3-kinase (PI3K)-AKT pathway and mitogen activated kinase (MAPK) pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Mycobacterium tuberculosis)
• Uncoupling protein 2-acetylation by sirtuins signaling pathway (2018, NA)
• Regulatory network of C2H2-ZFPs in floral organ development (2018, NA)
• Structure and functions of chondroitin sulfate proteoglycan 4 (CSPG4) (2018, NA)
• Cellular PRRs: Toll and Imd pathways (2018, NA)
• Toll-like receptor (TLR) 4 signaling pathway (2018, NA)
• Effects of vitamin D of inflammation in tumorigenesis (2018, Homo sapiens,Mus musculus,Canis lupus familiaris,Mycobacterium tuberculosis)
• C-C chemoattractant cytokine (chemokine) receptor 6 (CCR6) activation pathway (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,Mouse mammary tumor virus,Homo sapiens,Mus musculus)
• Activation and Attenuation of IL-33/ST2 Signaling (2018, NA)
• IL-33 localization and cytokine function (2018, NA)
• Intracellular signalling pathways of vitamin A (2018, NA)
• Apoptosis inhibition in cancer (2018, NA)
• Apoptosis intrinsic (endoplasmic reticulum (ER)) pathway (2018, NA)
• Apoptosis extrinsic and intrinsic (mitochondrial) pathways (2018, NA)
• Summary of the effects of the MC1R agonists Alpha-MSH and ACTH and the antagonists ASIP and HBD3 on functional MC1R, and the impact of loss of function of MC1R on these effects (2018, NA)
• Brief overview of canonical and non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) activation pathways (2018, NA)
• Proposed mechanism showing how RP11-79H23.3 as a ceRNA regulates the PTEN/PI3K/AKT pathway in the pathogenesis and development of BC (2018, NA)
• HH-GLI signaling pathway (2018, NA)
• Schematic drawing of the possible signalling pathways regulated by PACAP in bone formation (2018, Bos taurus,Oryctolagus cuniculus,Gallus gallus,Capra hircus,Sus scrofa,Triportheus paranensis,Chamaeleo chamaeleon,Paracheirodon innesi,Homo sapiens,Mus musculus,Senegalia senegal)
• The gustatory pathway, depicting the major central synaptic relays and their connections with structures involved in metabolic, reward and learning, and memory processes (2018, NA)
• Endoplasmic reticulum (ER) and mitochondria interactions (2018, NA)
• Metabolic implications associated to ceramide synthesis (2018, NA)
• Main metabolic pathways triggered by chronic brain hypoperfusion (CBH) (2018, NA)
• Proposed signaling pathways in the development of hepatic portal hypertension (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• DP2 receptor-mediated response of immune cells in the inflammatory pathway (2018, NA)
• Signaling pathways of high-risk HPV oncogenes (2018, Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,human papillomavirus 11,Homo sapiens,Mus musculus,Nicotiana tabacum)
• Prx II regulates CSC properties of colorectal cancers via PI3K/AKT, Hedgehog and Wnt/Beta-Catenin signaling (2018, NA)
• Overexpressed Prx II regulates stemness-associated properties of HCC cells (2018, NA)
• Nlrp12 in regulating early TCR signaling pathways, T cell activation and proliferation (2018, NA)
• NFKB1 p105/p50 regulation of gene expression in cancer (2018, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Nicotiana tabacum,Helicobacter pylori,NA)
• Canonical and DNA damage-induced NFKB signalling pathways (2018, NA)
• P53-ARF-MDM2/4 pathway (adapted from the p53 website) (2018, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• CCN2 in palate developmental pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• CCN2 in regulation of LRP5/6 dependent Wnt signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Repurposing of drugs on YAP (Yes-1 associated protein)-TEAD (transcriptional enhanced associate domain) system through cross-talking pathways (2018, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Hippo pathway upstream modulation (2018, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Lipid and FA modulation in Vitis vinifera cv (2018, Vitis vinifera,Plasmopara viticola)
• Protein lysine acetylation plays a regulatory role in Bacillus subtilis multicellularity (2018, Bacillus subtilis,Homo sapiens)
• Wound healing, cellular regeneration and plasticity: the elegans way (2018, Homo sapiens,Caenorhabditis elegans)
• Wound healing, cellular regeneration and plasticity: the elegans way (2018, NA)
• Smoke-induced microRNAs and their target genes (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Nicotiana tabacum)
• Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy (2018, NA)
• NLRP3 priming following TLR activation (2018, Saccharomyces cerevisiae,Staphylococcus aureus,Candida albicans,Listeria monocytogenes,Homo sapiens,Mus musculus)
• NLRP3 inflammasome assembly (2018, Saccharomyces cerevisiae,Staphylococcus aureus,Candida albicans,Listeria monocytogenes,Homo sapiens,Mus musculus)
• Canonical and non-canonical inflammasomes.Notes: Canonical inflammasomes assemble downstream of cytosolic PRRs including NLRP1, NLRP3, NLRC4, AIM2, and pyrin and control the activation of caspase-1 (2018, Saccharomyces cerevisiae,Staphylococcus aureus,Candida albicans,Listeria monocytogenes,Homo sapiens,Mus musculus)
• The proposed pathways activated by LPS to modulate mTOR-dependent autophagy and the production of pro-inflammatory cytokines in Caco-2 and HT-29 cells (2018, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides,gut metagenome)
• Cooperation between c-Myc and YAP/TAZ or HSF1 cofactor (a) Phosphorilation of YAP/TAZ by Hippo signaling pathway promotes cytoplasmic localization and ubiquitin-mediated degradation (2018, NA)
• Orlistat from PxEA perspective (2018, NA)
• Wnt/Beta-catenin driven mevalonate metabolism promotes EMT (2018, Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG)
• Signaling pathways inhibited by salirasib (2018, Homo sapiens,Bos taurus,Curcuma longa)
• Fibrogenic secretome pathways in the development of fibrosis (2018, Homo sapiens,Mus musculus,Danio rerio)
• Crosstalk between the interferon signaling pathway and PD-L1 signalosome (2018, Homo sapiens)
• Extracellular matrix organization pathway genes in COPD disease network module (2018, Homo sapiens,Mus musculus)
• Impact of osmotic stress on central carbon metabolism (2018, NA)
• Proposed model for PD-L1 induction in CC (2018, Homo sapiens,Mus musculus,vectors)
• Βeta-TRCP in regulating the Wnt signaling (2018, NA)
• Hepatitis E Virus life cycle (2018, Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Dengue virus,Vaccinia virus,West Nile virus,Japanese encephalitis virus,Dengue virus type 2,SARS coronavirus NS-1,Homo sapiens,Mus musculus,NA,NA,NA)
• Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase (2018, Trypanosoma cruzi,Homo sapiens)
• TGFB signaling and apoptosis (2018, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,Respiratory syncytial virus,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Reovirus sp.,Betapolyomavirus hominis,Human T-cell lymphotropic virus,Mammalian orthoreovirus,Reovirus S4,Drosophila melanogaster,Antarctothoa delta,Homo sapiens,Mus musculus,Matthiola incana,NA,NA)
• Schematic pathway representing findings of this study (2018, NA)
• Contraction in ASM (2018, Homo sapiens)
• Tetrazolium dye reduction reflects the combinational effect of cell number, medium glucose supply and cellular glucose metabolic activity (2018, Homo sapiens,Rattus norvegicus,Bos taurus)
• In chronic energy excessive conditions, the causes of insulin resistance (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• PI3K/AKT pathway in normal state and insulin resistance (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• PI3K/AKT pathway and liver metabolism (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• PI3K/AKT pathway in muscle tissue when normal state and insulin resistance (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• PI3K/AKT pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• WNT/Beta-catenin signalling (2018, NA)
• Protective function of the calcium-sensing receptor against inflammation and carcinogenesis in the colon (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Autotaxin-lysophosphatidic acid signaling axis regulates adipose tissue development and glucose homeostasis in obesity (2018, NA)
• Biochemical pathways of lysophosphatidic acid synthesis and degradation (2018, NA)
• HMGB1 signaling pathway in cerebrovascular disease (2018, NA)
• Primary and acquired resistance to CD38 antibodies (2018, NA)
• Accessory Toxins of Vibrio Pathogens and Their Role in Epithelial Disruption During Infection (2018, Escherichia coli,Vibrio cholerae,Vibrio parahaemolyticus,Vibrio vulnificus,Vibrio anguillarum,Vibrio cholerae O1 biovar El Tor,Vibrio cholerae O1,Vibrio cholerae non-O1non-O139,Vibrio coralliilyticus,Vibrio mimicus,Vibrio vulnificus MO6-24O,Vibrio cholerae O1 str. Haiti,Bos taurus,Oryctolagus cuniculus,Bacteriophage sp.,Filamentous phage,Homo sapiens,Mus musculus,uncultured marine bacterium,Galleria mellonella)
• G protein-related high light, cold and ER stress in plants (2018, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Brassica napus,Pisum sativum,Spermatophyta,Camelina sativa,Homo sapiens,Escherichia coli)
• Nrf2/AR signaling is at the crossroads of Wnt and Akt/FOXO signaling pathways (2018, Saccharomyces cerevisiae,Armoracia rusticana,Nicotiana tabacum,Schizosaccharomyces pombe,Curcuma longa,Agaricus bisporus,Brassica oleracea,Cinnamomum verum,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Helicobacter pylori,Bacillus subtilis,Pyrococcus furiosus,Solenopsis invicta,Lucilia cuprina,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus,Danio rerio,Sus scrofa,Xenopus laevis,Callithrix jacchus,Tobacco mosaic virus)
• Human CARD9 signaling pathway (2018, Homo sapiens)
• Human Disease Phenome construction (2018, Homo sapiens,Galea musteloides)
• The mechanisms of action of metformin (Adapted from He and Wondisford, 2015) (2018, NA)
• Mapping of the DE genes exclusive to the oval morphotype on the SNARE interactions in vesicular transport pathway issued from the KEGG metabolic pathway– (2018, PX clade,Phaeodactylum tricornutum,Thalassiosira pseudonana,Pseudo-nitzschia multistriata,Seminavis robusta,Homo sapiens,Drosophila melanogaster)
• Mapping of the DE genes exclusive to the oval morphotype on KEGG metabolic pathways– (2018, PX clade,Phaeodactylum tricornutum,Thalassiosira pseudonana,Pseudo-nitzschia multistriata,Seminavis robusta,Homo sapiens,Drosophila melanogaster)
• Core interactions between the mTOR pathway and Alzheimer's disease (2018, Mus musculus,Rattus norvegicus,prion,unidentified,Bryophyta,Merluccius merluccius,Arctium lappa,Pollachius virens,Homo sapiens,Viana)
• Distinct metabolic pathways in cancer cells and their connection to epigenetic modifications (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sesamum indicum,Homo sapiens)
• Metabolism of SAM (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sesamum indicum,Homo sapiens)
• Schematic diagram of the molecular mechanisms underlying K63‐linked polyubiquitination and cardiac hypertrophy (2018, NA)
• BH4 modulates the nitrosation of key proteins in the Ubiquitin-Proteasome system (2018, Homo sapiens,Mus musculus,Escherichia coli)
• Graphical Abstract (2018, Zea mays,Glycine max,Arachis hypogaea,Mus musculus,Rattus norvegicus,Gallus gallus,Salmo trutta,Homo sapiens,Capra hircus)
• Notch pathway, showing therapeutic points for targeting Notch3 (2018, NA)
• Smad-dependent and Smad-independent pathways of TGFB signaling associated with EndMT (2018, NA)
• Pathways to retinal regeneration (2018, Danio rerio,Xenopus laevis,teleost fish,Oryzias latipes,Carassius auratus,Salmo trutta,Merluccius merluccius,Paracheirodon innesi,Maylandia benetos,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cavia porcellus,Solanum lycopersicum,Arachis hypogaea,Homo sapiens,Conus striatus)
• Real-time carbon allocation into biogenic volatile organic compounds (BVOCs) and respiratory carbon dioxide (CO2) traced by PTR-TOF-MS, 13CO2 laser spectroscopy and 13C-pyruvate labelling (2018, Nicotiana tabacum,Zea mays,Solanum lycopersicum,Embryophyta,Triticum aestivum,Vitis vinifera,Helianthus annuus,Spinacia oleracea,Citrus aurantiifolia,Populus deltoides,Quercus ilex,Halimium halimifolium,Tuber magnatum,Manduca sexta,Erebia epipsodea,Platalea alba,Homo sapiens)
• RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation (2018, NA)
• GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway (2018, NA)
• PKCι drives both common and lineage-specific oncogenic pathways in lung cancer (2018, NA)
• Epigenetic mechanisms of nanotopography-guided osteogenic differentiation of mesenchymal stem cells via high-throughput transcriptome sequencing (2018, NA)
• SS2 metabolic pathways differentially regulated in carbohydrate metabolism (2018, Streptococcus suis,Homo sapiens)
• The role of Wnt5a-Ror2 signaling in osteoclast differentiation (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Citrus medica)
• Prostate Cancer Metastasis (2018, Homo sapiens,Mus musculus)
• Various published mechanisms of resistance to FMS-like tyrosine kinase 3 inhibitors (2018, Clostridioides difficile,Clostridioides difficile CD34,Clostridioides difficile CD38,Homo sapiens,Mus musculus,murine stem cell retroviral vector)
• Hypothetical model for the signaling pathway and the role of FKB-induced autophagy in GBM cells (2018, Homo sapiens,Piper methysticum)
• Targeting the cell cycle in breast cancer (2018, Homo sapiens)
• SRSF1 regulates SUMO conjugation to different spliceosomal proteins (2018, NA)
• Human disease genetics implicates EP4-SIK2-CRTC3-CREB pathway in the regulation of IL-10 levels and IBD susceptibility (2018, NA)
• Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator (2018, Saccharomyces cerevisiae,Arachis hypogaea,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• VAV1 signaling in lymphocytes (2018, NA)
• Inverse relationship between canonical and non-canonical Hedgehog signaling in colon cancer stem cell (CSC) differentiation (2018, Homo sapiens)
• Mediating the death of dormant tumor cells (2018, Homo sapiens,Mus musculus)
• RAS/SKP2-driven K63-linked ubiquitination of LKB1 modulates LKB1 activation (2018, NA)
• Dual Regulation of NFKB signaling by SIRT6 (2018, NA)
• Induction of various signaling cascades and their interactions under heavy metal stress (2018, NA)
• Pictorial representation of un-inhibited Avian avulavirus 1 (APMV-1)-induced type I interferon (IFN) response in waterfowl cells (2018, NA)
• MiR-106p-5p in cervical cancer: from expression to molecular mechanism (2018, NA)
• Helicobacter pylori infection and inflammatory bowel disease (2018, NA)
• S100A10 and PAI-1 are regulated by Smad4-dependent TGFB1-mediated signaling and FOXC2-mediated PI3K signaling (2018, NA)
• Differential trafficking of somatostatin receptors (2018, NA)
• SST5signaling leading to inhibition of hormone secretion and proliferation (2018, NA)
• Role of Helicobacter pylori in the reprograming of cellular and molecular programs related to invasive behavior (2018, NA)
• TGF/Smad pathway (2018, Lareunionomyces loeiensis,Cinnamomum verum,Oenothera rosea,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Different modalities of cell death (2018, Lareunionomyces loeiensis,Cinnamomum verum,Oenothera rosea,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Prions activate a p38 MAPK synaptotoxic signaling pathway (2018, NA)
• A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity (2018, NA)
• Pathway and network analyses showing major cellular processes associated with persistence of BD (2018, NA)
• Canonical Wnt/Beta-catenin signaling pathway (2018, Homo sapiens)
• HER2 signaling pathway (2018, Homo sapiens)
• PLVAP regulates vascular development and function (2018, NA)
• The mechanism by which HIV-1 Vpr promotes KSHV latency and cytokine production (2018, Human immunodeficiency virus 1,Human gammaherpesvirus 8)
• Lipogenesis and cholesterol synthesis pathways (2018, Bos taurus,Capra hircus,Sus scrofa,Equus caballus,Diaporthe sclerotioides,Hordeum vulgare,Matthiola incana,Homo sapiens)
• Galactose metabolism, glycosylation and inflammatory cascades in galactosaemia (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Autophagic control of Toxoplasma gondii (2018, Toxoplasma gondii,Homo sapiens)
• STAT 3 signaling pathway and site of action of napabucasin (2018, NA)
• Metabolic pathway for isopropanol–butanol–ethanol (IBE) production (2018, NA)
• Illustration showing different mechanisms underlying diabetic retinopathy (2018, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens)
• Important steps in cholesterol synthesis and homeostasis (2018, Homo sapiens)
• TGFB signaling maintains homeostasis between the proliferation and apoptosis of normal epithelial cells by Smads or other Smad-independent downstream pathways (2018, NA)
• Pathway-pathway crosstalk via GADD45B (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• STAT3 activation pathway (2018, Homo sapiens,Mus musculus)
• The effects of CLN3, flupirtine, retigabine, and benzyl (compound 5) or allyl (compound 6) carbamate derivatives on ceramide synthesis and intrinsic/extrinsic apoptotic pathways (2018, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Gallus gallus)
• Molecular mechanisms of TNBC (2018, Homo sapiens,Mus musculus)
• Proposed model for mechanism of matrine activity on human GBM cells (2018, NA)
• JAK-STAT signaling in tandem with multiple cytokines and hormones participates in the regulation of Beta-cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Mouse mammary tumor virus,Hericium erinaceus)
• Binding of growth factors and hormones to their respective receptors or ligands serves a pivotal role in Beta-cell proliferation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Mouse mammary tumor virus,Hericium erinaceus)
• Binding of PDGF, GLP-1, IGF-1 and BTC to their respective receptors serves an important role in Beta-cell proliferation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Mouse mammary tumor virus,Hericium erinaceus)
• Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re)myelination (2018, NA)
• AHCY activity, DNA damage and the regulation of the cell cycle in hepatocellular carcinoma cells (2018, NA)
• Action of OR2AT4 activation by Sandalore® and (unknown) endogenous ligand(s) in human hair follicle epithelium (2018, NA)
• Opsin3—A Link to Visible Light-Induced Skin Pigmentation (2018, NA)
• Gut-brain communicates with the brain mainly via three pathways of the microbiota–gut–brain axis (2018, NA)
• Changes in transcript abundance of genes involved in central metabolic pathways and antioxidant system when Schizochytrium sp (2018, NA)
• Role of AMPK signalling pathway during compensatory growth in pigs (2018, Saccharomyces cerevisiae,Bos taurus,Sus scrofa,Candida dubliniensis,Homo sapiens,Mus musculus)
• The two commonly activated pathways and genetic aberrations involved in thyroid cancer, as well as the targeted therapies studied in thyroid cancer (2018, NA)
• Oxygen-substrate stoichiometry in brain (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Hippo signaling pathway in Mammals (2018, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Melia azedarach)
• Thrombosis and bleeding pathways in patients with ventricular assist device (2018, NA)
• Effects of low-frequency ultrasound in PTX-resistant PC-3 cells (2018, Homo sapiens,Rattus norvegicus,Bos taurus)
• Regulation of AMPK signaling in DM1 muscle (2018, Homo sapiens,Mus musculus)
• Proposed model for depolarization-triggered activation of the ERK/CREB pathway via a direct interaction of the intracellular B2b with H-Ras (2018, NA)
• IL-13 inhibition of LPS-induced BPIFA1 expression in nasal polyps and adenoid tissue (2018, NA)
• Tentative Model Explaining Redirection of Metabolism in the Absence of MDH2 during Photoautotrophic N Deprivation.FA degradation starts with hydrolysis of TAGs and membrane lipids by lipases (2018, PX clade,Chlamydomonas reinhardtii)
• Hepatic lipid metabolic pathways investigated in this study (2018, NA)
• Cannabinoid 1 receptor (CB1R) actions in Beta-cells (2018, NA)
• Schematic overview of light-regulated translational control pathways in the SCN (2018, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Neurospora crassa,Euglena gracilis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780 (2018, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Ovis aries)
• ROS signaling and ER stress in cardiovascular disease (2018, NA)
• NFKB signal transduction pathway (2018, NA)
• Diseases and functions analysis by integrated pathway analysis using 20 MeDEGs (2018, Homo sapiens,Mus musculus)
• Schematic pathway of ROS generation and induction of DA neurons death (2018, Mus musculus,Rattus norvegicus,Diphasiastrum complanatum,Huperzia selago,Homo sapiens)
• Wingless/integrated (Wnt) signaling pathway (2018, NA)
• Stabilizing and destabilizing signals for Tregs (2018, NA)
• Immunobiology of Ubiquitin-Dependent B Cell Receptor Functions (2018, NA)
• Predicted target genes of miR-125a-5p and let-7e-5p in the Inflammatory response molecular network (2018, NA)
• Visualization of KEGG IL17 signaling pathway genes differentially perturbed (FDR < 0.05) in rat muscle infected with A (2018, Anisakis pegreffii,Homo sapiens)
• Enriched KEGG neurotrophin signaling network following perinatal nicotine exposure in DA neurons (2018, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Iris germanica,Homo sapiens)
• Enriched KEGG dopaminergic synapse pathway following perinatal nicotine exposure in DA neurons (2018, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Iris germanica,Homo sapiens)
• E2 on bovine mammary epithelial cells during Staphylococcus aureus infection (2018, Staphylococcus aureus,Homo sapiens)
• Anti-inflammatory and antibacterial effects of E2 in epithelial cells (2018, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Staphylococcus aureus,Ovis aries,Staphylococcus aureus 1-B-1,Mus musculus,Rattus norvegicus,Homo sapiens,Capsicum chinense)
• Signal transduction pathways of epithelial cells in pathogen recognition (2018, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Staphylococcus aureus,Ovis aries,Staphylococcus aureus 1-B-1,Mus musculus,Rattus norvegicus,Homo sapiens,Capsicum chinense)
• Immune suppressive nature of CIN-induced inflammation (2018, Homo sapiens)
• CIN activates cGAS-STING signaling (2018, Homo sapiens)
• Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1–nuclear factorKB/p65 pathway in RAW264.7 macrophages and in COPD mice (2018, Ophiocordyceps sinensis,Homo sapiens)
• Can WRKY transcription factors help plants to overcome environmental challenges? (2018, NA)
• Compound 7l induced apoptosis of leukaemia stem and progenitor cells through MAPK signal pathway (2018, NA)
• DACT2 and the Beta-catenin/Cdc25c pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Danio rerio,Human gammaherpesvirus 4)
• Lymphangiogenesis therapies: learning from current anti-angiogenesis therapies - A review (2018, NA)
• Modulating Inflammation through the Negative Regulation of NFKB Signaling (2018, NA)
• Modulating Inflammation through the Negative Regulation of NFKB Signaling (2018, NA)
• Modulating Inflammation through the Negative Regulation of NFKB Signaling (2018, NA)
• Sketch diagram illustrated the target genes by the selected miRNAs in ROS-AKT-cyclinsenescence pathway (2018, NA)
• The effects of NBUVB on the bulge and epidermis of human vitiligo skin during repigmentation (2018, NA)
• Pathways Involved in Ovarian Epithelial Cancer (2018, Homo sapiens)
• Composite pathway using the KEGG pathway analysis, a composite pathway was generated based on the canonical mapping of the phosphorylated proteins independently associated with increased % collagen (red) in the liver (2018, NA)
• Mechanism of action of FSH on adipocytes (2018, NA)
• TNFR2-triggered, necrostatin-1-sensitive TNFR1 signaling (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Mycobacterium tuberculosis,Mycobacterium avium,Homo sapiens,Armoracia rusticana)
• Scheme of cascade of events representing the role of zinc in the regulatory crosstalk promoting myogenesis (2018, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Drosophila melanogaster)
• KEAP1-NRF2 pathway is altered in human lung cancers.Schematic of KEAP1-NRF2 pathway under homeostatic conditions (left), oxidative conditions (center) or synergistic conditions, for example in a cancer cell (right) (2018, NA)
• Schematic depiction of the results and proposed hypothesis (2018, Homo sapiens,Mus musculus)
• HIV infection on neurons’ A7-nAChRs (2018, NA)
• Proposed decarboxylation pathway for fenclozic acid via M35, M34, M33, and M26, leading to the formation of M8 and thence to M9 via glycine conjugation (2018, NA)
• Metabolic engineering of the glycolysis pathway in E (2018, NA)
• Phosphatidylinositol signaling pathway (2018, NA)
• Mechanism underlying the protective effect of HIF-1 in HI (2018, NA)
• PI3K/Akt signaling pathway in HI (2018, NA)
• Autophagy in neutrophil biology and disease (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Listeria monocytogenes,Streptococcus pneumoniae,Bacillus anthracis,Acinetobacter baumannii,Burkholderia pseudomallei,Mus musculus,Saccharomyces cerevisiae,Cavia porcellus,Candida albicans,Homo sapiens)
• Sub-pathway of the HIF-1 signaling pathway identified on the basis of sub-pathway strategy (2018, NA)
• Sub-pathway of chemokine signaling pathway identified on the basis of sub-pathway strategy (2018, NA)
• Sub-pathway of the MAPK signaling pathway identified on the basis of sub-pathway strategy (2018, NA)
• PCV2-induced apoptosis (2018, NA)
• Activation mechanisms of the Hippo kinase signaling cascade (2018, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Triticum aestivum,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Summary and working hypothesis (2018, Danio rerio,Xenopus laevis,Phoenicopterus roseus,Chamaeleo chamaeleon,Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Drosophila melanogaster)
• GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation required for PI3KG/PREX1 signaling and robust T cell cytokine secretion (2018, Homo sapiens)
• Transcription factor interactions in endothelial cell functions (2018, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Current pathogenic model of psoriasis (2018, Homo sapiens,Mus musculus)
• mTOR/STAT3 signaling pathway in T helper 17 cells (2018, NA)
• Metabolic pathway influenced by patulin and Protein interaction network of Kcr proteins (2018, Rhodotorula mucilaginosa,Homo sapiens)
• Schematic showing how inhibition of FXa attenuates ALI progression via modulation of the PAR-2/NFKB signaling pathway (2018, NA)
• Regulation of cell signaling pathways involved in cancers by KDM2B (2018, NA)
• C3 inhibitor Cp40 and its targets in the setting of periodontitis (2018, NA)
• Neurotrophin Trafficking via Trk Receptors (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Neurotrophin Trafficking via Trk Receptors (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Agaricus bisporus)
• mTOR pathway (2018, NA)
• Cellular metabolism for heme synthesis during early and late erythropoiesis (2018, NA)
• Energy metabolism and lactate-mediated responses (2018, Homo sapiens)
• Representation displaying the two different signaling pathways, RET-dependent (A) and RET-independent (B).In RET-dependent, glial cell line-derived neurotrophic factor (GDNF) binds directly to GDNF family receptor alpha (GFRA)1 (2018, Homo sapiens)
• Trichosanthes kirilowii lectin alleviates diabetic nephropathy by inhibiting the LOX1/NFKB/caspase-9 signaling pathway (2018, Trichosanthes kirilowii,Homo sapiens)
• Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry (2018, NA)
• Long non-coding RNAs affect epithelial-mesenchymal transition in gastric cancer cells (2018, NA)
• Role of p21-activated kinases in Kras-driven oncogenic signalling pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Possible cellular mechanisms attributed to oxidative stress in Parkinson’s disease (PD) and possible effects of natural antioxidants on specific pathway (2018, Malus domestica,Olea europaea,Panax ginseng,Curcuma longa,Allium cepa,Cicer arietinum,Scutellaria baicalensis,Citrus x paradisi,Linum usitatissimum,Rhodiola rosea,Apium graveolens,Gastrodia elata,Dendrobium nobile,Gynostemma pentaphyllum,Apium graveolens Secalinum Group,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,prion)
• Functions of iTreg in the TME (2018, NA)
• Schematic diagram illustrates how tilorone and hypoxia may share common mechanisms in the mediation of the preconditioning response (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,NA)
• Oxygen sensing HIF prolyl hydroxylases modulate transcriptional and metabolic adaptive responses (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,NA)
• Intracellular signaling pathway following sequential treatment with celecoxib and bortezomib in human colorectal cancer cells (2018, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Pathway diagram presenting chaetominine mode of action associated with cell cycle regulation in SW1116 and K562 cells (2018, NA)
• miRNA-core gene-risk signaling pathway regulation network (2018, Homo sapiens)
• miRNA-risk genes-pathways regulation network (2018, Homo sapiens)
• Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic implications in a peripheral neuropathy (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Paraechinus aethiopicus)
• Nuclear factor KB (NFKB) activation signaling pathways.Canonical NFKB pathway: the canonical pathway is inhibitor of KB (IKB) kinase (IKK)-dependent and IKB-dependent (2018, NA)
• Leptin intracellular signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Camelus bactrianus)
• mPGES-1 and MAPKs in jurkat cells (2018, NA)
• CREB as an integrative signaling molecule involved in schizophrenia (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Signaling pathways of the unfolded protein response (2018, NA)
• Simplified KEGG pathway “Proteoglycans in Cancer” with H3K4me3 and H3K27me3 enriched genes (2018, NA)
• Scheme of possible mechanisms by which autoimmune diseases are mediated by IGF-IGFBP signaling pathways (2018, Homo sapiens,Mus musculus)
• CARMA/CARD-dependent and-independent MALT1 activation (2018, NA)
• Signaling via MALT1 downstream of various receptors and CARMA/CARD proteins (2018, NA)
• The molecular mechanisms underlying the role of mTOR/p70S6K/HIF-1A signaling pathway in the regulation of TLR4 inflammatory signaling and TH17 cells in liver IRI (2018, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Nodal and Shh Signaling (2018, NA)
• Human and yeast peroxisomal Beta-oxidation pathways (2018, Homo sapiens,Saccharomyces cerevisiae)
• Somitogenesis and somite patterning (2018, NA)
• Schematic model demonstrating how PTH signaling leads to changes in SOST and RANKL expression in osteocytes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Regulation of Muc1/Flo11 protein (2018, Saccharomyces cerevisiae,Homo sapiens)
• Brown adipocyte glucose metabolism: a heated subject (2018, NA)
• Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models (2018, Homo sapiens,Drosophila melanogaster)
• Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments (2018, NA)
• Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins (2018, NA)
• Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins (2018, NA)
• DP dependent regulation of Cx43 phosphorylation and degradation (2018, NA)
• Mechanism of XWL-1-48 inhibits growth of breast cancer cells (2018, NA)
• HUWE1-mediated proliferation/differentiation (2018, NA)
• The pathways being affected by MDD and by treatments (2018, NA)
• Multiple pathways of CD44/CD44v6-promoted CIC motility: CD44/CD44v6 drive CIC motility by activation of signaling cascades as well as protease activation (2018, NA)
• CD44/CD44v6 and CIC apoptosis resistance (2018, NA)
• Simplified illustration of YAP/TAZ and glycolysis (2018, Homo sapiens,Mus musculus)
• Hippo signaling pathway (2018, Homo sapiens,Mus musculus)
• Single-strand break signaling (2018, NA)
• Two major signaling axes in IGF-1-mediated EMTs in human breast, lung, and gastric cancers (2018, NA)
• Putative regulatory mechanisms of the FNM process (2018, NA)
• Akt/mTOR pathway in schizophrenia (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris,prion,Streptomyces hygroscopicus,Tor tor)
• Mammalian target of rapamycin (mTOR) pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris,prion,Streptomyces hygroscopicus,Tor tor)
• MDSCs expansion is regulated by several factors in vivo microenvironment (2018, NA)
• HO-1 dependent pathway activated in neurons and in the different glial cells (2018, Mus musculus,Rattus norvegicus,Glycine max,Sophora alopecuroides,Homo sapiens,Adenoviridae)
• Summary of CIPK14 or/and WHIRLY1/3 mediated pathways in chloroplasts, including light reaction, chlorophyll metabolism, ROS scavenging, malate biosynthesis, calvin cycle, and protein metabolism (2018, NA)
• Crosstalk between Hh signaling and autophagy based on current evidence (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Mycobacterium tuberculosis,Paraechinus aethiopicus)
• Role of TLR3, 7 and 9 in SS (2018, Human T-cell leukemia virus type I,Coxsackievirus,Murid gammaherpesvirus 4,Mammalian orthoreovirus 1,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Inhibition of apoptosis mediated by mFas and TRAIL (2018, Human T-cell leukemia virus type I,Coxsackievirus,Murid gammaherpesvirus 4,Mammalian orthoreovirus 1,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Carbon monoxide on the cardiovascular system (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Activation of mTOR signalling pathway by growth factors (2018, NA)
• Pin1 in the metabolic pathway acts as a negative regulator of AMPK (2018, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Lareunionomyces loeiensis)
• Mammalian target of rapamycin (mTOR) pathway (2018, NA)
• KEGG and BioCarta pathways of proteins encoded by genes related to cell cycle and ROS whose expression was altered in BS-24-1 cells after treatment with ethyl acetate extract of A (2018, Asteriscus graveolens,Homo sapiens)
• Multiple potential neuroprotective mechanisms in Shh signaling pathway (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Human immunodeficiency virus 1,Mycobacterium tuberculosis,Paraechinus aethiopicus)
• Catabolic and pro-inflammatory signaling in osteoarthritis (2018, NA)
• Pathogenicity and factors associated with the disruption of the normal cellular activity (2018, NA)
• Putative targets of up-regulated miRNAs in SHH MB CSC enriched pathways, include (A) pathways in cancer, (B) PI3K-Akt pathway, and (C) protein processing in endoplasmic reticulum (2018, NA)
• Signaling pathways involved in TNF/Thy-1-induced astrocyte polarization and migration (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Homo sapiens)
• Prolactin-driven signaling pathways via the short or long prolactin receptors (2018, NA)
• Schematic Overview of Salt Stress-Induced Changes in Auxin Biosynthesis, Conjugation, and Transport-Related Processes in the Arabidopsis Roots (2018, NA)
• mBDNF/TrkB and proBDNF/p75NTRsignaling pathways regulate gamma-aminobutyric acid neurotransmission (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Innate Immune Signaling and Alcohol Use Disorders (2018, NA)
• MIM through MOM: the awakening of Bax and Bak pores (2018, NA)
• Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood (2018, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides,Venustaconcha ellipsiformis)
• Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood (2018, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides,Venustaconcha ellipsiformis)
• Network of “Target-Pathway” in osteosarcoma (OS) based on the collected data from – (2018, Homo sapiens,Bos taurus)
• Downstream consequences of neurotrophin signalling pathway affecting gene function and ER stress marker is possibly implicated in progression of RGCs axon damage in glaucoma (2018, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Coturnix coturnix,Marmota monax,Saccharomyces cerevisiae,Adeno-associated virus,Felis catus,Mustela putorius furo,Azadirachta indica,Adeno-associated virus - 1,Homo sapiens)
• The BDNF/ TrkB signalling in normal and glaucomatous conditions (2018, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Coturnix coturnix,Marmota monax,Saccharomyces cerevisiae,Adeno-associated virus,Felis catus,Mustela putorius furo,Azadirachta indica,Adeno-associated virus - 1,Homo sapiens)
• Production and function of hydrogen sulfide in plants (2018, NA)
• Network created by Ingenuity Pathway Analysis using the top 36 most highly connected genes disrupted by rolandic epilepsy (RE) CNVs as assessed by the Disease Association Protein-Protein Link Evaluator (2018, NA)
• E-cadherin in Contact Inhibition and Cancer (2018, NA)
• Regulation of the Hippo signaling pathway (2018, NA)
• Sphingosine-1-phosphate signaling in Leishmania donovani infection in macrophages (2018, NA)
• Progression and environmental sensitivity of C (2018, NA)
• Model showing the role of iRhom2 as a positive regulator of PM2.5-induced renal injury (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Listeria monocytogenes)
• Platelet hyperreactivity in type 2 diabetes mellitus (2018, Oryza sativa,Olea europaea,Theobroma cacao,Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta)
• TGFB1 and E2 cause differential regulation of genes involved in extracellular matrix turnover (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Gallus gallus,NA)
• MAPK signaling pathway (2018, NA)
• Biochemical mechanisms of oncometabolite accumulation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,NA)
• Mitochondria at the crossroad of metabolic and signaling networks (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,NA)
• Gene networks involved in a) 'developmental disorder, ophthalmic disease, organismal injury and abnormalities' (score = 41) and b) 'cell-to-cell signaling and interaction, nervous system development and function, inflammatory disease' (score = 21) (2018, NA)
• GT-induced anoikis signalling (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetus cricetus,Borreliella burgdorferi,Clostridium botulinum,Hathewaya limosa,Homo sapiens,Aspergillus fumigatus)
• Highly connected networks built using reperfusion-upregulated mRNAs coding for proteins known to interact with human proteins (2018, NA)
• CircRNA and cancer-associated signaling pathways (2018, NA)
• Polymerase-related genes identified using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Gorilla gorilla,Bos taurus,Drosophila melanogaster)
• Interferon pathway (2018, NA)
• Wnt Signaling Cascade (2018, Homo sapiens,Mus musculus)
• Pathway for Type I tumor formation (2018, Homo sapiens,Mus musculus)
• TRPM7 kinase in T cell signalling and transcriptional regulation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,gut metagenome)
• TGFB signalling pathway (2018, NA)
• miRNA regulatory pathway in the control of the protein synthesis through SIRT1—TSC:mTOR (2018, NA)
• Honey Bee Immune Pathways—Highlighting Genes Implicated in Antiviral Immune Responses (2018, NA)
• Anti-cancer mechanism of the PEC treatment in both AGS and MKN28 cells (2018, NA)
• SUMOylation system and TGFB signaling interplay (2018, NA)
• TGFB-Smad signaling pathway (2018, NA)
• Summary of the signaling pathways involved in cell migration and invasion through p75NTR (2018, NA)
• In some cases, migration and invasion are stimulated through NGF or proNGF upon activation of p75NTR and TrkA (2018, NA)
• p75NTR and TrkB pathways (2018, NA)
• Change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats (2018, Rattus norvegicus,Cavia porcellus,Homo sapiens,Salmo trutta)
• Palbociclib resistance and MAP kinase pathway inhibition (2018, Homo sapiens,Mus musculus)
• FABP5-mediated transcriptional controlling network of mitochondrial functions in PCa cells (2018, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,vectors)
• AMPK activates DAPK2 to promote autophagy (2018, NA)
• Low-complexity metabolic network model for the respiratory and fermentative metabolism of Escherichia coli (2018, NA)
• Virus-related products in the inflammatory tumor microenvironment (2018, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Inflammatory mediators in hepatocellular carcinoma (2018, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Tumor-associated macrophages and epithelial-to-mesenchymal transition in hepatocellular carcinoma (2018, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Synthesis, metabolism and anticancer mechanism of vitamin D (2018, NA)
• The biosynthetic pathway of cholesterol and GGPP which regulates tumor angiogenesis process using cholesterol depleting agents (statins) (2018, Human gammaherpesvirus 4,Avian sarcoma virus,Homo sapiens,Mus musculus,Danio rerio,Borreliella burgdorferi,Rheum palmatum)
• Schematic presentation of MAPK/Ras signaling pathway (2018, Human gammaherpesvirus 4,Avian sarcoma virus,Homo sapiens,Mus musculus,Danio rerio,Borreliella burgdorferi,Rheum palmatum)
• The human adrenal cortex: growth control and disorders (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Regulation of inflammatory arachidonic acid (AA) derivatives after Leishmania infantum or Leishmania donovani infections (2018, NA)
• Summary of apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like (APOBEC)3B transcriptional regulations in cancer cells (2018, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,Human papillomavirus type 16,Adeno-associated virus,DNA viruses,Saccharomyces cerevisiae,Diaporthe sclerotioides,Helicobacter pylori,Helicobacter pylori 35A,Homo sapiens,Mus musculus)
• Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway (2018, Mus musculus,Rattus norvegicus,Danio rerio,Armoracia rusticana,Diaporthe sclerotioides,Oryzias latipes,Homo sapiens)
• Protein-protein interaction networks of DEGs involved in the staphylococcus aureus infection signaling pathway (2018, NA)
• Hepatocarcinogenesis (2018, NA)
• Signalling pathway by which kallistatin inhibits endothelial senescence, oxidative stress and inflammation (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Caenorhabditis elegans,Armoracia rusticana,Turdus migratorius)
• Proposed working model for the role of Rho GTPases in S1P‐induced GEnC activation in the presence of MPO‐ANCA‐positive IgG (2018, Homo sapiens,Adeno-associated virus - 4)
• Regulation of cancer cell proliferation by PIP5KA that is a target of NEDD4‐dependent proteasomal degradation (2018, NA)
• Hippo-YAP signaling and the pathogenesis of gastric cancer (2018, NA)
• Apoptotic signaling pathway induced by emodin in HepaRG cells (2018, NA)
• MiR-146a-5p in the Toll-like receptor signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Schematic Diagram Illustrates and Summarizes the Role and Signaling Pathway of PAK1 in Regulating Human SSCsPAK1 is mediated by EGF, but not by GDNF or FGF2; PDK1, ZNF367, and KDR are the targets of PAK1 (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Armoracia rusticana)
• D5R mutation induces dilated cardiomyopathy that is related to oxidative stress (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Vasconcellea candicans)
• Summary of roles of different DUBs on the development of cardiac hypertrophy (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Human gammaherpesvirus 4)
• Summary of roles of different E3 ligases on the development of cardiac hypertrophy (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Human gammaherpesvirus 4)
• Direct and indirect mechanisms of action of metformin in cancer cells (2018, NA)
• KLHDC7B and the Interferon signaling pathway (2018, Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens,Anser sp.,bacterium NOTE)
• Phenotype change of microglia in neurodegenerative disorders (2018, NA)
• Schematic representations of the two main mechanisms that activate NFKB in thyroid cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Exploiting vita-PAMPs in vaccines (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Bacillus subtilis,Influenza A virus,unidentified influenza virus,Dengue virus,Zika virus,Mycobacterium tuberculosis variant bovis BCG,H5N1 subtype,Borreliella burgdorferi,Salmonella enterica subsp. enterica serovar Typhi,Variola virus,H7N9 subtype,Shigella flexneri 2a,H10N8 subtype,Bos taurus,Sus scrofa,Lareunionomyces loeiensis,Candida albicans,Sus scrofa domesticus,Quillaja saponaria,Homo sapiens,Mus musculus,NA)
• Cross-talk between oestrogen (ER) and epidermal growth factor receptor (EGFR)/insulin-like growth factor 1 receptor (IGF-1R) signalling pathway and cyclin-dependent kinase (CDK)4/6 function (2018, NA)
• Cellular protection mechanism conferred by Nrf2-ARE pathway after intracerebral hemorrhage (ICH) (2018, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Rubus coreanus,Homo sapiens)
• cAMP/PKA network (2018, NA)
• Complement activation and involvement during alcoholic liver disease (2018, Homo sapiens,Mus musculus)
• PD-1/PD-L1 signaling and reprograming in T cells (2018, NA)
• Possible mechanisms by which central Ang II facilitates the micturition reflex (2018, Rattus norvegicus,Homo sapiens)
• Model: SIRT6 levels regulate resistance or sensitivity to MAPKi (2018, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Equus caballus,Calloplesiops altivelis)
• Pictorial Abstract (2018, NA)
• EphB4-Fc suppresses osteoclast formation and bone resorption (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Porphyromonas gingivalis)
• Role of EpCAM in cell signaling (2018, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Canis lupus familiaris)
• Functional analysis of transcription factors and genes in dysregulated miR-FFLs (2018, NA)
• Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease (2018, NA)
• Primary myelofibrosis based on results obtained in animal models (2018, NA)
• Insulin receptor (IR) and IGF-1 receptor (IGF-1R)-mediated proliferation of IESCs (2018, NA)
• IFNG signaling pathway (2018, NA)
• Overview of RNA-sensing pathway (2018, NA)
• RAS/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Diaporthe sclerotioides,Panthera pardus)
• MiR-30a significantly promotes cell apoptosis by regulating several relevant effectors (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• MiR-30a significantly inhibits cell proliferation (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Granulocyte activation and diapedesis mediators show greater induction during diestrus phase infection than in estrus (2018, NA)
• Viral carcinogenesis pathway and differentially expressed genes in primary NSCLC tumors (2018, NA)
• Neuropathology following treatment with NP03-lithium (2018, NA)
• Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis (2018, NA)
• Persistent EcoHIV infection induces nigral degeneration (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,West Nile virus,Murine leukemia virus,Homo sapiens,Mus musculus)
• Cut loose and run: The complex role of ADAM proteases during neural crest cell development (2018, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Xenopus tropicalis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Monodelphis domestica)
• Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Zea mays,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster,gut metagenome,Simian endogenous retrovirus)
• Investigating genetic-and-epigenetic networks, and the cellular mechanisms occurring in Epstein–Barr virus-infected human B lymphocytes via big data mining and genome-wide two-sided NGS data identification (2018, NA)
• Tissue alcohol metabolism contributes to tissue and organ injury through altered redox potential, generation of ROS, and generation of metabolites, such as acetaldehyde, that form DNA and protein adducts (2018, NA)
• Mechanisms of interaction between IL-6 and TGFB leading to fibrosis in SSc (2018, NA)
• Pharmacological targets of ErbB2 signaling pathway in Her2-enriched subtype (2018, NA)
• Schematic illustration of the PTEN regulated PI3K-AKT-mTOR signaling pathways in CNS axon regeneration (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Gallus gallus)
• E2/ER/WWOX in initiating protective pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,prion,Middle East respiratory syndrome-related coronavirus)
• Schematic summary of HIF-1 signaling in hypoxia and diabetes (2018, NA)
• TGFB induces CD103 expression in tumor-specific T cells and participates in integrin bidirectional signaling (2018, Homo sapiens,Mus musculus,Artichoke latent virus)
• Simplified schematic showing the potential strategy for muscle‐derived miR‐23a/27a to attenuate muscle atrophy and renal fibrosis (2018, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Adeno-associated virus,adeno-associated virus 2,Homo sapiens)
• PTEN lipid phosphatase inactivation in gastric tumorigenesis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Helicobacter pylori)
• Schematic diagrams of SOS1 activation (2018, NA)
• Autophagy contributes to integrin recycling and degradation (2018, NA)
• Representative cell cycle pathway between PCOS arrested and non-arrested 2-cell embryos (2018, Homo sapiens)
• Role of free tRNALeu (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Escherichia coli,Human T-cell leukemia virus type I)
• Major Nai influx and efflux pathways and metabolic pathways involved in ATP supply (2018, Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Mustela putorius furo,Mus musculus,Rattus norvegicus,Cavia porcellus,Gallus gallus,Triportheus paranensis,Homo sapiens,Candida dubliniensis)
• Cell cycle proteins mediating progression during MI (2018, NA)
• Cilia and intraflagellar transport (2018, Caenorhabditis elegans,Trypanosoma brucei,Paracentrotus lividus,Leishmania mexicana,Tetrahymena thermophila,Saccharomyces cerevisiae,Diaporthe sclerotioides,Chlamydomonas reinhardtii,Sesamum indicum,Homo sapiens,Mus musculus,Rattus norvegicus,Hylobates sp.)
• Homeostasis, regeneration and tumour formation in the mammalian epidermis (2018, NA)
• IFNG-induced autophagy is regulated by HMOX1 (2018, Mycobacterium tuberculosis)
• Signaling pathway of OS and pregnancy (a brief view) (2018, NA)
• Regulation network of circRNAs in cancer (2018, NA)
• Schematic overview of LATS1/YAP/RHAMM pathway and the regulatory effects of LATS1 in the LATS1/YAP/RHAMM pathway (2018, NA)
• Beneficial effects and potential mechanisms of GK against ischemic insults (2018, NA)
• Working pathway for Er-Miao-Fang inhibiting inflammation and blocking hepatic gluconeogenesis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Atractylodes lancea,Phellodendron chinense,Atractylodes chinensis,Homo sapiens,Mus musculus,Danio rerio)
• Interactions of Lactobacillus rhamnosus GG or LRY (green) with Helicobacter pylori (red) and damaged epithelial cells at the gastric mucosal surface (2018, NA)
• VEGF and Notch interaction in physiological and tumor angiogenesis (2018, NA)
• Crosstalk between Notch and tumor necrosis factor A (TNFA) in the tumor environment (2018, NA)
• Interplay between IL-6 and Notch affects the anticancer immune response (2018, NA)
• Fas-mediated EGF-induced EGFR signaling A proposed model of the robust EGF-induced EGFR signaling pathway mediated by the pro-survival, phosphorylated Fas that can lead to aggressive behavior of cancer cells is presented here (2018, NA)
• Mevalonate-isoprenoid-cholesterol pathway and pharmacological agents that inhibit the synthesis of key intermediates (2018, NA)
• BPS-induced placental dysfunction working model (2018, Bos taurus,Armoracia rusticana,Capra hircus,Zea mays,Ovis aries,Wisteria floribunda,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Jaagsiekte sheep retrovirus)
• Following stroke, the stability of NICD is increased by its interaction with Pin1, and the NICD-Pin1 complex then translocates to the nucleus (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Sus scrofa)
• Notch signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Sus scrofa)
• Ischemic stroke initiates cell death mechanisms in brain cells following an acute depletion of blood flow, resulting in the formation of an infarct core (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Sus scrofa)
• Crosstalk of the Hedgehog pathway with other protumorigenic pathways (2018, NA)
• Mechanism of Hedgehog pathway activation (2018, NA)
• Double strand break chromatin stability mechanisms (2018, NA)
• Metabolic pathway map (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Insulin signalling pathway activated in retina and RB (2018, Homo sapiens,Mus musculus,Danio rerio,NA)
• Multi-target interaction of chalcones on cross-talk between Nrf2 and NFKB response pathways involved in inflammation (2018, Carthamus tinctorius,Humulus lupulus,Toxicodendron vernicifluum,Piper methysticum,Glycyrrhiza inflata,Dalbergia odorifera,Corylopsis coreana,Lophira alata,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA,NA)
• Proposed immunopathophysiological mechanisms of stress-limiting effects of 1,3,4-thiadiazine compounds in myocardial infarction (based on the compound L-17 properties) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Human alphaherpesvirus 3,Pseudomonas aeruginosa EC2A)
• DBTD decreases the intracellular TG by promoting fatty acid B oxidation and inhibiting lipogenesis through blocking the mTOR pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Anser sp.)
• The potential pathway underlying the anticancer activity of CK in human HCC cells (2018, NA)
• IL-33 signaling pathway (2018, Arachis hypogaea,Ambrosia artemisiifolia,Artemisia vulgaris,Cryptomeria japonica,Vaccinia virus,Variola virus,Dermatophagoides farinae,Heligmosomoides polygyrus,Dermatophagoides pteronyssinus,Variola minor virus,Mus musculus,Cavia porcellus,Homo sapiens,Staphylococcus aureus)
• Model about the effect of indoleamine 2,3-dioxygenase 1 (IDO1) on the utilization of the main energy sources by activated CD4+ T-cells (2018, NA)
• Ubiquitylated sites in proteins revealed by diGly proteomics in PC9/GR cells (2018, NA)
• Bile acids are synthesized in the liver from cholesterol by two metabolic pathways known as the neutral (or classical) and the acidic (alternative) pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Sus scrofa,Diaporthe sclerotioides,gut metagenome)
• The role played by TCL1 in multiple signaling pathways (2018, NA)
• Transforming growth factor‐B (TGF‐B) promotes T helper 17 (Th17) differentiation through multiple mechanisms (2018, NA)
• Tumor Epigenetically Upregulated Genes (EUG) in Epstein-Barr Virus Infection pathway (2018, NA)
• Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums (2018, NA)
• The effects of gambogic acid (GBA) on lipopolysaccharide (LPS)-stimulated raw 264.7 cells (2018, NA)
• Schematic representation for the possible interaction of viral oncogene proteins with various levels of Wnt/Beta-catenin cell signaling cascade (2018, NA)
• Schematic diagram for the activation of BMPs, Wnt, and MAPK pathways by phytochemicals treatment (2018, Glycine max,Embryophyta,PX clade,herbal medicine,Salvia miltiorrhiza,Theobroma cacao,Ginkgo biloba,Carthamus tinctorius,Astragalus membranaceus,Papaver somniferum,Angelica sinensis,Aloe vera,Centella asiatica,Butea monosperma,Morinda citrifolia,Ligustrum lucidum,Digitalis purpurea,Selaginella tamariscina,Neocheiropteris fortunei,Mimosa tenuiflora,Zanthoxylum schinifolium,Cissus quadrangularis,Ferula hermonis,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• STEP-mediated signaling cascade in ALS (2018, NA)
• Stimuli-induced TLR2- and NOD2- mediated signaling (2018, Staphylococcus aureus,Homo sapiens)
• Action of PAC-1 combination therapy with clinically approved kinase inhibitors examined in this work (2018, Homo sapiens,Oryctolagus cuniculus,NA)
• TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts (2018, NA)
• Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition (2018, Homo sapiens,Mus musculus,Armoracia rusticana,Canis lupus familiaris,vectors,Human betaherpesvirus 5)
• Targetable cell survival mechanisms.Notes: Stimulation of the BCR and its co-receptor CD19 results in downstream signaling via the PI3K/AKT/mTOR pathway (2018, Homo sapiens)
• Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set (2018, NA)
• TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set (2018, NA)
• MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set (2018, NA)
• Focal adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2414 set (2018, NA)
• TGF-beta adhesion signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2404 set (2018, NA)
• TGF-beta signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set (2018, NA)
• MAPK signaling highlighted in KEGG pathway analysis in parallel with SPIA pathway analysis by using microarray result of SNU-2335 set (2018, NA)
• EnhAP1-OIS1 regulation of OIS (2018, Homo sapiens,Mus musculus,H-1 parvovirus)
• Merged network analysis from Ingenuity Pathway Analysis (IPA) software for associations among molecules related to rheumatoid arthritis, inflammation of joint, cell cycle and apoptosis (2018, NA)
• Carbohydrate‐mediated folding in the endoplasmic reticulum (2018, Human immunodeficiency virus 1,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,H1N1 subtype,Zika virus,West Nile virus,H5N1 subtype,Ebola virus,Japanese encephalitis virus,H3N2 subtype,Lyssavirus rabies,Simian immunodeficiency virus,Infectious bronchitis virus,H7N9 subtype,Rift Valley fever virus,Influenza A virus H3N2,Venezuelan equine encephalitis virus,Human rotavirus,mosquito-borne viruses,Bamboo mosaic virus,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Solanum tuberosum,Hordeum vulgare,Malus domestica,Nicotiana benthamiana,Medicago sativa,Lactuca sativa,Chenopodium quinoa,Nicotiana plumbaginifolia,Candida pruni nom. inval.,Valeriana edulis,Bursera graveolens,Apis mellifera,Leishmania major,Trichoplusia ni,Acropora indonesia,Oryctolagus cuniculus,Ovis aries,Mustela putorius furo,Mus musculus,Gallus gallus,Cricetulus griseus,Anser indicus,Homo sapiens,vectors,Vibrio cholerae,NA,NA,NA)
• Relationship between individual genes composing the ‘blood vessel development’ ontology group (2018, NA)
• The Cold Signaling Pathway and Its Regulation of Genome-Wide Gene Expression.Cooling activates Ca2+-dependent kinases and MAP kinases that activate or repress transcription factors or splicing factors (2018, NA)
• Several lncRNAs work at the post-transcriptional level as competing endogenous RNAs for microRNAs, titrating microRNA effector complexes away from their mRNA targets (e.g (2018, NA)
• LncRNAs can regulate gene expression by participating in chromatin looping (e.g (2018, NA)
• LncRNAs activate (e.g (2018, NA)
• Several lncRNAs bind to specific combinations of regulatory proteins, potentially acting as scaffold elements within ribonucleoprotein complexes, stabilizing their targets (e.g (2018, NA)
• Several lncRNAs interact with transcription factors recruiting them to their target genes (e.g (2018, NA)
• Protein-protein interaction network of predicted target genes of hsa-miR-1 (2018, NA)
• Androgen signaling pathway in granulosa cells of the primordial follicle (2018, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Equus asinus,Homo sapiens,Macaca mulatta,marmosets,Mus musculus,Oryza sativa)
• Beta-AR signaling in cardiomyocytes under physiological condition (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Adeno-associated virus)
• Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes (2018, NA)
• Kynurenine pathway activation in inflammatory conditions (2018, NA)
• Anti-inflammatory function of tumor necrosis factor receptor-associated factor (TRAF)2 and TRAF3 in toll-like receptor (TLR) signaling pathway (2018, NA)
• Function and regulation of tumor necrosis factor receptor-associated factor (TRAF)6 in MyD88 signaling pathway (2018, NA)
• Toll-like receptor (TLR) signaling pathways (2018, Escherichia coli,Enterococcus faecalis,Porphyromonas gingivalis,Bacillus anthracis,Fusobacterium nucleatum,Streptococcus mutans,Prevotella intermedia,Enterococcus faecalis PF3,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Models for Golgi fragmentation induced by truncated APC (2018, NA)
• Wnt-mediated regulation of drug resistance (2018, NA)
• NFKB inflammatory signaling pathway (2018, Alternanthera sessilis,Homo sapiens)
• DNA Damage Response (DDR) Pathway (2018, Homo sapiens,Mus musculus)
• Inhibition of mTOR activity with rapamycin (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homotherium serum,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Papaya ringspot virus,NA)
• Targeting prohibitins at the cell surface prevents Th17‐mediated autoimmunity (2018, Homo sapiens,Mus musculus)
• Metabolic model of Acetothermia sp (2018, Synechocystis sp.,Clostridium acetobutylicum,Clostridium perfringens,Caulobacter vibrioides,Thermotoga maritima,Pyrococcus furiosus,Thermococcus kodakarensis KOD1,Rhizobium phaseoli,Asticcacaulis biprosthecium,Candidatus Acetothermum autotrophicum,Acetothermus paucivorans,Candidatus Fermentibacter daniensis,Candidatus Promineofilum breve,Candidatus Bipolaricaulis anaerobius,Candidatus Acetothermia bacterium,Thermovirga lienii,Asticcacaulis benevestitus,metagenome,metagenomes,activated sludge metagenome,uncultured bacterium,uncultured Acetothermia bacterium,Saccharomyces cerevisiae,Thunnus alalunga,Homo sapiens)
• Gene enrichment analysis of protein-coding genes co-expressed with DE lncRNAs (2018, NA)
• MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development (2018, NA)
• Dkk3 (dickkopf-3)/CXCR7-mediated Sca-1+ progenitor migration (2018, NA)
• The applied conditions on the expression of central metabolism genes (2018, Synechococcus elongatus,Homo sapiens)
• Regulation, function, and targeting of IDO1 in cancer (2018, NA)
• Molecular interactions between LRRK2, aSyn and p38 MAPK in the regulation of apoptosis and autophagy (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Hepatitis B virus,prion)
• Kyoto Encyclopedia of Genes and Genomes pathway analysis of the hub gene secreted LY6/PLAUR domain and its connected genes (2018, NA)
• Signaling pathways activated by temozolomide in glioma cells (2018, Homo sapiens)
• Simplified general overview of glucose, fatty acid, and amino acid metabolism in healthy endothelial cells (2018, NA)
• Gene network of the susceptibility pathways/GO terms (2018, NA)
• Metabolic pathway map in the plasma comparing common bottlenose dolphins (n = 3, blue columns) and beagle dogs (n = 3, red columns) (2018, Canis lupus familiaris,Delphinus delphis,Homo sapiens)
• Activation and feedback regulation of the MAPK pathway (2018, Homo sapiens)
• Major downstream targets of ERK1/2 in the MAPK pathway (2018, Homo sapiens)
• Pathways of T-cell inactivation and mechanisms of monoclonal antibodies (2018, NA)
• Relationship between AR translocation and the AKT signaling pathway (2018, NA)
• Rubone and the p53 pathway (2018, NA)
• Interaction network of paeonol and known gastric cancer genes (2018, NA)
• PM2.5 induced cardiac hypertrophy via CREB/GSK3b/SOS1 pathway and metabolomics alterations (2018, NA)
• Summary of the location pattern of CFP (blue), YFP (yellow), neuronal (PV) and activity markers (Arc) in the hippocampus (2018, Mus musculus,Homo sapiens)
• Mutation frequency of selected pathways (2018, NA)
• Methods for observation and quantification of apoptosis (2018, Escherichia coli,Mycobacterium tuberculosis,Escherichia coli FAP1,Homo sapiens,Mus musculus,Drosophila melanogaster,Citrus macrophylla,NA)
• Androgen receptor signaling axis and potential androgen-dependent and independent mechanisms of disease progression (2018, Homo sapiens,Mus musculus)
• TLRs mediated the T cells response and programmed cell death process toward tumor environment (2018, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis BCG str. China,Mycoplasmopsis arginini,Homo sapiens,Mus musculus)
• Tetraspanin roles during HIV-1 infection (2018, NA)
• AD genes selected by cross metrics analysis and their relation with other diseases (2018, NA)
• Summary of the role of muscle-specific A-kinase anchoring protein (mAKAP) polymorphisms in the cAMP/PKA signaling pathway (2018, NA)
• polyunsaturated fatty acids in the endocannabinoid system (2018, PX clade,Helianthus annuus,Camelina sativa,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Scheme depicting the mechanism underlying mitofilin knockdown-induced increase in cell death by apoptosis (2018, NA)
• JAK–STAT signaling and core cancer pathways (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Signaling cascades for YAP/TAZ regulation (2018, NA)
• Apoptosis in Acetaminophen Hepatotoxicity (2018, herbal medicine,Panax ginseng,Angelica sinensis,Rosa laevigata,Gentiana manshurica,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed signaling mechanisms of adiponectin in prevention of ischemic stroke (2018, NA)
• Type I IFN-dependent pathway and ER stress response-induced pathway of IFNAR1 degradation (2018, Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Orthomyxoviridae,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,H5N1 subtype,Enterovirus A71,Ebola virus sp.,Suid alphaherpesvirus 1,Human metapneumovirus,Murid gammaherpesvirus 4,Tick-borne encephalitis virus,Murid herpesvirus 68,Infectious bursal disease virus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• Lipid metabolism in tumor cells (2018, Saccharomyces cerevisiae,Oryza sativa,Candida dubliniensis,Fusarium graminearum,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Clostridium perfringens,NA)
• Network mappings were Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of HOXA3 co-expression genes in NSCLC (2018, Homo sapiens,Listeria monocytogenes,clinical samples,Paracyclopina nana,NA)
• Kinases associated with the CX3CL1/CX3CR1 axis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,clinical samples)
• Proposed model of host signaling cascade in response to microbial signals to promote hematopoiesis (2018, Homo sapiens)
• Synaptic signaling pathways associated with autism spectrum disorder (ASD) (2018, NA)
• Working model for ADAM12 during proliferation in preadipocytes (2018, Homo sapiens,Mus musculus,Bos taurus)
• Targets of signaling pathways (2018, Armoracia rusticana,Panax notoginseng,Glycyrrhiza uralensis,Astragalus membranaceus,Schisandra chinensis,Ophiopogon japonicus,Codonopsis pilosula,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Compound–target network (2018, Armoracia rusticana,Panax notoginseng,Glycyrrhiza uralensis,Astragalus membranaceus,Schisandra chinensis,Ophiopogon japonicus,Codonopsis pilosula,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Gold nanoparticles and Wnt/Beta-catenin signaling pathway (2018, NA)
• Primary DAEC expansion and differentiation.(A) Proliferating human DAECs and their fate after induction and feeder removal in vitro (2018, Influenza A virus,unidentified influenza virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,H2N2 subtype,H4N6 subtype,Bos taurus,Canis lupus familiaris,Sus scrofa,Mustela putorius furo,Mus musculus,Rattus norvegicus,Gallus gallus,Anas platyrhynchos,Homo sapiens,Helicobacter pylori,Aguna panama)
• Metabolic reprogramming of cancer cells in the tumor microenvironment (TME) (2018, Homo sapiens,Mus musculus,Candida dubliniensis)
• Metabolism is a key feature of every quiescent cell (2018, Homo sapiens,Mus musculus,Candida dubliniensis)
• Adenosinergic pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Diaporthe sclerotioides)
• NOD-like receptor signaling pathway (2018, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Akkermansia muciniphila,Candidatus Arthromitus sp. SFB-mouse,Ruminococcus gnavus,Enterococcus gallinarum,Enterococcus casseliflavus,Bacteroidales incertae sedis,Enterobacteriaceae incertae sedis,gut metagenome,metagenome,metagenomes,feces metagenome,Mus musculus,Rattus norvegicus,Sequoia sempervirens,Cenchrus americanus,Cofana spectra,Neocloeon triangulifer,Homo sapiens,Bos taurus,Dicentrarchus labrax)
• Model depicting the proposed effect of the membrane-permeant peptide TAT-GESV on NMDAR signaling in neuropathic pain (2018, Mus musculus,Rattus norvegicus,Cricetulus griseus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Matthiola incana)
• Major areas of the ascending pain system and locations of plasticity (2018, Homo sapiens)
• Metabolic pathways contributing to HSC self-renewal and differentiation (2018, NA)
• Host-Intrinsic Interferon Status in Infection and Immunity (2018, Mus musculus,Mus musculus castaneus,Mus musculus molossinus,Mus musculus musculus,Mycobacterium tuberculosis,Listeria monocytogenes,unidentified influenza virus,Vesicular stomatitis virus,Legionella pneumophila,Yaba-like disease virus,Homo sapiens,Gallus gallus,NA,NA)
• GAi3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana)
• Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC (2018, NA)
• Proposed model for RGS9–2 regulation of NMDAR function and synaptic signaling in D2-MSNs (2018, Mus musculus,Homo sapiens)
• Ingenuity Pathway Analysis of Molecular Activation Based on Gene Expression Profiles(A) Gene expression data were analyzed by Ingenuity Pathway Analysis (2018, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens)
• Smurf2 as an oncogene (2018, NA)
• Signaling pathways engaged by the LMP2A gene (2018, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human alphaherpesvirus 3,Human betaherpesvirus 6,Human betaherpesvirus 7,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,stable RNAs,NA)
• LMP1 in the carcinogenesis of nasopharyngeal carcinomas (2018, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human alphaherpesvirus 3,Human betaherpesvirus 6,Human betaherpesvirus 7,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,stable RNAs,NA)
• Antidepressant and anxiolytic mechanism of acupuncture in a PTSD rat model (2018, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Autoimmune Responses in Severe Asthma (2018, NA)
• Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms (2018, NA)
• Cranberry-derived proanthocyanidins induce a differential transcriptomic response within Candida albicans urinary biofilms (2018, NA)
• Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner (2018, Leishmania donovani,Homo sapiens)
• Nuclear effects of DRD1/PKA pathway and reactive species on postsynaptic neurons (2018, Homo sapiens)
• BRAF and MEK Inhibitors: Use and Resistance in BRAF-Mutated Cancers (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Molecular regulation in autophagy (2018, Human immunodeficiency virus 1,Listeria monocytogenes,Respiratory syncytial virus,Shigella flexneri,Homo sapiens,Mus musculus)
• Developments in toxicogenomics: understanding and predicting compound-induced toxicity from gene expression data (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gorilla gorilla,Streptococcus pneumoniae)
• Gga-miR-302b-5p and gga-miR-302-3p miRNAs (2018, Oryctolagus cuniculus,Equus asinus,Homo sapiens,Mus musculus,Gallus gallus,unidentified influenza virus)
• Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance (2018, NA)
• JAK2 protein in intracellular crosstalk (2018, NA)
• JAK/STAT pathway in cancer cells (2018, NA)
• Mechanism of Homologous Recombination (HR) (2018, Molva molva,Xenopus tropicalis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Anti-inflammatory strategies of alveolar macrophages (2018, NA)
• WNT pathway promoting endometrial carcinogenesis (2018, Homo sapiens)
• mTOR pathway in endometrial carcinogenesis (2018, Homo sapiens)
• Several Proposed important schematic signaling pathways for Gankyrin in tumorigenesis (2018, Homo sapiens)
• YAP regulates innate antiviral immunity via a transcription-independent mechanism (2018, NA)
• KEGG pathway functional analysis of differentially expressed genes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,vectors,Lepidium sativum)
• Simplified schematic of the ERK pathway (2018, NA)
• Pharmacological mechanism of roflumilast in the treatment of asthma–COPD overlap (2018, NA)
• Crosstalk between EGFR and the TF-FVIIa-PAR2 pathway (2018, NA)
• Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment (2018, NA)
• Programmed cell death: the battlefield between the host and alpha-herpesviruses and a potential avenue for cancer treatment (2018, NA)
• Patterns in evolutionary origins of heme, chlorophyll a and isopentenyl diphosphate biosynthetic pathways suggest non-photosynthetic periods prior to plastid replacements in dinoflagellates (2018, NA)
• TGFB-dependent signaling implicated in fibrosis process (2018, NA)
• Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis (2018, Homo sapiens)
• Schematic presentation elucidating proposed mechanisms that TLB protects PC12 cells against oxidative stress-induced injury (2018, Mus musculus,Rattus norvegicus,Glycine max,Vasconcellea candicans,Homo sapiens,Bos taurus,Danio rerio)
• Simplified link between ΔCT of each microRNA and apoptotic molecules in peripheral blood mononuclear cells (PBMCs) in our study (2018, Hepatitis B virus,Human gammaherpesvirus 4,H5N1 subtype,Enterovirus A71,Hepatovirus A,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Chlamydia pneumoniae,NA)
• MRN complex activates possible (alternative) pathways at DSBs (2018, Escherichia coli,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human adenovirus 5,Thermotoga maritima,Methanocaldococcus jannaschii,Pyrococcus furiosus,Escherichia coli IS5,Human adenovirus sp.,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Coprinopsis cinerea,Thermochaetoides thermophila,Homo sapiens,Mus musculus,Xenopus laevis,Tequatrovirus T4,NA)
• Schematic view of pathways regulating IL-1A expression in hRPE cells (2018, Mus musculus,Rattus norvegicus,Capra hircus,Mycobacterium tuberculosis,Ovis aries,Bacillus cereus,Homo sapiens,Armoracia rusticana,Human betaherpesvirus 5)
• Network obtained from genes sharing different pathways (2018, NA)
• Sodium fluoride induces autophagy in mammalian mice spleen (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Capra hircus,Ligustrum vulgare,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• PD-1 in T-cell activation, exhaustion and effector function.Notes: (A) T-cells are activated via (1) binding of MHC plus peptide on an APC to the TCR and then (2) binding of APC CD80/86 to T-cell CD28 (2018, NA)
• E2-ERB signaling in GnRH neurons at proestrus afternoon and its proposed action on presynaptic GABA and glutamate release (2018, NA)
• Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges (2018, NA)
• Mechanisms underlying the effects of Stachys sieboldii (SS) (2018, Hordeum vulgare,Prunus dulcis,Withania somnifera,Garcinia mangostana,Ishige foliacea,Stachys affinis,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Canis lupus familiaris)
• Major downstream signaling pathway of mTORC1 and mTORC2 (2018, NA)
• APC activity is decreased under nutrient conditions, and increased when nutrients are limiting (2018, NA)
• GHR-JAK2-STAT pathway inhibition mediated by PTP-1B, SHP-1, SHP2 and SIRPA1 (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Ctenopharyngodon idella)
• Activation of the growth hormone receptor and its signal transduction (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Ctenopharyngodon idella)
• Silver nanoparticles on the cell stress response pathways (2018, NA)
• Disruption of ncRNA Networks in Cancer (2018, NA)
• Time Dependent Pathway Activation of Signalling Cascades in Rat Organs after Short-Term Hyperoxia (2018, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster)
• Interaction of proteins 3 days after hyperoxia (2018, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster)
• Proteins with influence on cell-death related signal transduction (green/light green: up-regulation, red/light red: down-regulation) (2018, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster)
• Ingenuity pathways analysis (IPA) functional network generated for data of NH0-, NH3-, and NH7-groups (2018, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster)
• SCF and its active ingredients protect against inflammation in NDs (2018, Schisandra chinensis,Homo sapiens)
• Sonic Hedgehog (SHH)/Patched (PTCH1) and WNT signaling pathways (2018, NA)
• Mechanistic target of rapamycin (mTOR) signaling pathway (2018, NA)
• Signaling pathways were regulated by HSAF (2018, Alternaria alternata,Homo sapiens)
• Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells (2018, NA)
• Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells (2018, NA)
• Mechanism of modulation on sphingolipids (2018, Oryza sativa,Glycine max,Solanum lycopersicum,Solanum tuberosum,Triticum aestivum,Malus domestica,Olea europaea,Vitis vinifera,Arachis hypogaea,Curcuma longa,Agaricus bisporus,Camellia sinensis,Fragaria x ananassa,Spinacia oleracea,Brassica oleracea,Allium cepa,Theobroma cacao,Allium sativum,Daucus carota,Pyrus communis,Phaseolus vulgaris,Raphanus sativus,Ipomoea batatas,Cicer arietinum,Solanum melongena,Vicia faba,Petroselinum crispum,Cinnamomum verum,Avena sativa,Apium graveolens Dulce Group,Thymus vulgaris,Ocimum basilicum,Silybum marianum,Prunus dulcis,Prunus avium,Morus alba,Prunus armeniaca,Vaccinium myrtillus,Trifolium pratense,Rheum rhabarbarum,Psidium guajava,Humulus lupulus,Pleurotus ostreatus,Ficus carica,Coffea arabica,Apium graveolens,Cinnamomum aromaticum,Vicia faba var. minor,Euterpe oleracea,Cynara cardunculus,Prunus cerasus,Matricaria chamomilla,Oroxylum indicum,Maclura pomifera,Raphanus sativus var. niger,Passiflora caerulea,Argania spinosa,Rubus ulmifolius,Echinacea angustifolia,Avena nuda,Maclura tinctoria,Allium unifolium,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta,Apis mellifera)
• 8-HD and inflammatory signaling pathways (2018, NA)
• Endocytic trafficking of PAR1 (2018, NA)
• Simplified DNA repair pathway diagram (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanistic aspects of the antioxidant and anti-inflammatory action of berberine (2018, NA)
• Molecular signalling of TRAIL (2018, NA)
• Zyflamend and NFKB pathway (2018, Armoracia rusticana,Olea europaea,Curcuma longa,Zingiber officinale,Scutellaria baicalensis,Salvia rosmarinus,Origanum vulgare,Ocimum tenuiflorum,Berberis vulgaris,Homo sapiens,Mus musculus,Bos taurus)
• Hypothesized mechanisms by which JNK activation with exercise leads to muscle hypertrophy (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Triticum aestivum)
• Schematic represents various signaling pathways that occur within tumor cells, which allow for cell growth, proliferation, and invasion (2018, Nicotiana tabacum,Glycine max,Diaporthe sclerotioides,Arachis hypogaea,Curcuma longa,Brassica oleracea,Petroselinum crispum,Apium graveolens Dulce Group,Momordica charantia,Nasturtium officinale,Vassobia breviflora,Homo sapiens,Mus musculus,Human papillomavirus)
• Summary of scale development and schematic of molecular interactions (2018, Gallus gallus,Danio rerio,Dipturus trachyderma,Oryzias latipes,Carassius auratus,Dipnomorpha,Tetrapoda,Amniota,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny (2018, Danio rerio,Homo sapiens)
• Parental high dietary arachidonic acid levels modulated the hepatic transcriptome of adult zebrafish (Danio rerio) progeny (2018, Danio rerio,Homo sapiens)
• Proposed signaling pathways implicated in the promoter-specific expression of CYP19 in Hs578t cells (2018, Homo sapiens,Rattus norvegicus,Bos taurus,Zea mays)
• Apparent unidirectional fluxes of the LTP-mediated inter-organelle transport of lipids are indirectly coupled with metabolic reactions of lipids (2018, NA)
• Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox SignalingReviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward (2018, NA)
• MiRnome circulating in plasma after injury is predicted to be controlled by miRNA processing enzymes and to affect different signalling pathways (2018, NA)
• Analyzing Toll-like receptor signaling pathway by QIAGEN, KEGG and wikipathway websites and drawing pathway by Pathvisio software (2018, NA)
• Epstein–Barr virus (EBV) oncoproteins affecting p53 signaling pathways (2018, NA)
• Resistance to EGFR tyrosine kinase inhibitors (2018, NA)
• Neurotrophin signaling pathway and genes involved in the significant gene links (marked in red box) (2018, Saccharomyces cerevisiae,Nicotiana tabacum,Eucalyptus intertexta,Homo sapiens,Parthenos sylvia,bacterium 1-2B)
• Metabolic rewiring following T cell activation (2018, NA)
• Pathways of the annotated DE genes and lincRNAs in the adipose tissues of high- and low-FE pigs (2018, NA)
• Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response (2018, NA)
• Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response (2018, NA)
• Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response (2018, NA)
• Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response (2018, NA)
• PA induces the upregulation of PGC-1A expression via multiple signaling pathways (2018, Homo sapiens)
• Triptolide signaling pathway (2018, Mus musculus,Rattus norvegicus,herbal medicine,Tripterygium wilfordii,Homo sapiens,Bos taurus,Eimeria tenella)
• Oncogenic Signaling Pathways in The Cancer Genome Atlas (2018, NA)
• Radiation-Induced Bystander Effects via MAPK/NFKB Signaling Pathway (2018, NA)
• Canonical Wnt/Beta-catenin signaling pathway [,,,,,,,] (2018, NA)
• Canonical Hh signaling pathway (2018, NA)
• Phosphorylation of the HPV E6 PBM links cellular stress response signaling to E6 inhibition of p53 transcriptional activity (2018, NA)
• p53 signaling pathway (2018, NA)
• Fumarase functions in the human and yeast DNA damage response (DDR) to double-strand breaks (DSBs) (2018, NA)
• Lymphoma immune evasion mechanisms (2018, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• The HPA axis (2018, Homo sapiens,Rattus norvegicus,Diaporthe sclerotioides,Thomomydoecus minor)
• 7-ketocholesterol-induced leukocyte-endothelial interactions (2018, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Neisseria meningitidis)
• Role of Slfn2 in type I IFN signaling (2018, NA)
• ERA subcellular localization allows the activation of both nuclear and membrane-initiated signaling pathways (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Equus caballus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• Soluble klotho pleiotropic functions and FGF23 – sKlotho interactions (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of PtkA and their unusual IDD in the M (2018, NA)
• Differentiation of monocytes promotes resistance to ripoptosome signaling (2018, Mus musculus,Homo sapiens)
• Study of purinosome assembly in cell-based model systems with de novo purine synthesis and salvage pathway deficiencies (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Sarcocheilichthys parvus)
• Enriched pathways for radix tetrastigma hemsleyani flavonoid treated lung cancer cells (2018, herbal medicine,Astragalus membranaceus,Tetrastigma hemsleyanum,Homo sapiens,Bos taurus,Helicobacter pylori J99)
• Proposed mechanism for TSPO ligand-induced ATP release (2018, NA)
• Pathway for cerebral amyloid Beta-heme complex formation at sporadic Alzheimer’s disease (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Felis catus,Homo sapiens)
• Molecular mechanism of noradrenaline during the stress-induced major depressive disorder (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Pancreatic cancer microenvironment participates in metastasis (2018, NA)
• R431C mutation induces hyperproliferation, hypermotility and ER stress-induced apoptosis in podocytes (2018, Homo sapiens,Danio rerio)
• PKC pathway for prolactin regulation of the metabolic genes for citrate-producing prostate cells (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca radiata,Vasconcellea candicans)
• Integrative machine learning analysis of multiple gene expression profiles in cervical cancer (2018, Homo sapiens,Human papillomavirus,Saccharomyces cerevisiae PW5)
• Mapping transcripts on KEGG pathway (2018, Mus musculus,Rattus norvegicus,Sigmodon,Sigmodon hispidus,Sigmodon arizonae,Respiratory syncytial virus,Human orthopneumovirus,Homo sapiens,Crocus sativus,Carcinus maenas)
• LSEC and KC signaling pathways in 3DHLK systems (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• PPAR Signaling Pathway and the Terpenoid Backbone Biosynthesis Pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• Activation of a primordial follicle is regulated by Hippo and Akt signaling (2018, NA)
• Maintenance of a quiescent primordial follicle is regulated by Hippo and Akt signaling (2018, NA)
• Calcineurin–mitochondrial (CaN–mitochondrial) connection (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Presynaptic homeostatic functions of calcineurin (CaN) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Radix Rehmanniae in experimental autoimmune encephalomyelitis treatment (2018, herbal medicine,Momordica charantia,Rehmannia glutinosa,Homo sapiens,Callithrix jacchus,Escherichia coli O111B4,Mycobacterium tuberculosis H37Ra,Mus musculus,Bos taurus,Parthenolecanium pruinosum)
• DLX1/DLX2 may influence MAPT via WNT or GABA signaling pathway (2018, NA)
• An Orc1-2-centered network of DNA damage response in S (2018, NA)
• Toolbar, graphical elements supported in SPV and the mTOR pathway (2018, Homo sapiens,Mus musculus,Syringa vulgaris)
• Parkinson’s disease genes reveal an association of multiple variants that converge on deficiencies in cellular clearance (2018, NA)
• Endothelial injury pathways in thrombotic microangiopathies (2018, NA)
• Schematic diagram illustrating the main mechanisms implicated in the sensitization of D1R associated with LID (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Immunomodulatory approaches for the treatment and prevention of neonatal sepsis (2018, NA)
• Expanding complement therapeutics for the treatment of paroxysmal nocturnal hemoglobinuria (2018, NA)
• Signaling pathway involved in the neuroprotection of rhynchophylline (2018, Uncaria rhynchophylla,Homo sapiens)
• Overlapping actions of metformin and rapamycin (2018, Homo sapiens)
• lncRNAs involved in the IFN antiviral response (2018, NA)
• PPI networks for key KEGG pathways (2018, NA)
• miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer (NSCLC) through PD-L1 expression via the PTEN pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• YAP/TAZ as therapeutic targets in multiple mechanisms (2018, NA)
• Regulation of the Wnt pathway via YAP/TAZ (2018, NA)
• p53 signaling pathway obtained from the DAVID Database (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus asinus,Homo sapiens,Rattus norvegicus,Fragaria x ananassa)
• Mechanistic overview of AD with neuronal signaling pathways (2018, NA)
• Predicted regulatory networks affected by sinomenine treatment via Ingenuity®Pathway Analysis (2018, Homo sapiens,Rattus norvegicus,Plasmodium vivax,Sinomenium acutum)
• Function of Hsp70 in suppressing apoptosis after ischemic stroke (2018, NA)
• Regulation of GPCR signaling (2018, Homo sapiens)
• Molecular mechanism of MAHNP-DOX (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,unidentified)
• Pathways interactions of ethanolic extracts of Antrodia cinnamomea with ginger (2018, Saccharomyces cerevisiae,Armoracia rusticana,Curcuma longa,Zingiber officinale,Hibiscus sabdariffa,Aspergillus clavatus,Alpinia officinarum,Penicillium crustosum,Cinnamomum micranthum,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Staphylococcus aureus,Hepatitis B virus,NA,NA)
• Immunoglobulin G4-related disease (IgG4-RD) and immune pathways to therapy. Naïve B cells are activated by exposure to antigens (2018, NA)
• Altered B cell receptor (BCR) and co-receptor signaling promotes increased autoreactivity within the naive B cell repertoire (2018, NA)
• Signalling of melatonin receptor homomers and heteromers (2018, NA)
• Extended, context‐specific melatonin receptor signalling pathways (2018, NA)
• Interplay between melatonin and clock genes in joint during OA (2018, Homo sapiens)
• Effect of 20-HETE on different segments of the nephron to enhance natriuresis (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Death receptor signaling (2018, NA)
• Apoptosis inducing signaling pathway mediated by p53, AKT, MAPK activation to suppress ROS generated by Ag-NPs (2018, Saccharomyces cerevisiae,Diaporthe sclerotioides,PX clade,Candida albicans,Manihot esculenta,Nakaseomyces glabratus,Rhizopus arrhizus,Trichophyton rubrum,Trichoderma viride,Trichophyton mentagrophytes,Sesbania grandiflora,Lantana camara,Parthenium hysterophorus,Caulerpa racemosa,Pistacia atlantica,Calocybe indica,Abutilon indicum,Ziziphora tenuior,Tephrosia purpurea,Adiantum philippense,Delphinium denudatum,Pteris biaurita,Nephrolepis exaltata,Eucalyptus leucoxylon,Pteris argyraea,Couroupita guianensis,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica,Klebsiella pneumoniae,Enterococcus faecalis,Shigella flexneri,Pseudomonas fluorescens,Bacillus cereus,Chlamydia trachomatis,Staphylococcus epidermidis,Salmonella enterica subsp. enterica serovar Typhi,Enterococcus faecium,Aeromonas hydrophila,Micrococcus luteus,Proteus mirabilis,Limosilactobacillus fermentum,Shewanella oneidensis,Shigella boydii,Bacillus tequilensis,Kocuria rosea,Flavobacterium branchiophilum,Pseudomonas luteola,Human immunodeficiency virus 1,Influenza A virus,Dengue virus,H1N1 subtype,H5N1 subtype,Monkeypox virus,Drosophila melanogaster,Aedes aegypti,Culex quinquefasciatus,earthworms,Eisenia fetida,Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Equus caballus,Homo sapiens,Danio rerio)
• Functional neuroanatomy and molecular mechanisms of regulating immune responses (2018, Mus musculus,Rattus norvegicus,Staphylococcus aureus,Campylobacter jejuni,Homo sapiens,Canis lupus familiaris,Merluccius merluccius)
• B cell receptor signaling pathway and network of anti-inflammation (2018, Homo sapiens,Mus musculus,Bos taurus,Hydrangea paniculata)
• GPI biosynthesis in yeast (2018, Plasmodium falciparum,Trypanosoma brucei,Entamoeba histolytica,Homo sapiens,Candida albicans)
• Wnt/Beta-catenin signaling participates in HFD-induced depot-specific hypertrophy and hyperplasia (2018, Lareunionomyces loeiensis,Malus domestica,Pyrus communis,Mus musculus,Rattus norvegicus,Xenopus laevis,Meleagris gallopavo,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• Coenzyme Q10 deficiencies: pathways in yeast and humans (2018, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Saccharomyces cerevisiae CAT-1,Mus musculus,Rattus norvegicus,Escherichia coli,Caulobacter vibrioides,Homo sapiens,Caenorhabditis elegans)
• Pan-Cancer Analysis Reveals the Functional Importance of Protein Lysine Modification in Cancer Development (2018, NA)
• COX-2 regulates SSTR-2 expression (2018, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• Schematic diagram showing proposed pathway through which cyclic mechanical loading regulates primary cilia expression to control tendon matrix turnover (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Venustaconcha ellipsiformis)
• Neural crest induction by Dkk2 and Wnt8 (2018, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• Calcineurin pathway in T cells and amplification of NFATc1/A (2018, Homo sapiens,Mus musculus,Corynebacterium phage gamma)
• Rho GTPase Effectors and NAD Metabolism in Cancer Immune Suppression (2018, NA)
• Lipopolysaccharide (LPS)‐ and serum amyloid A (SAA)‐mediated cellular production of inflammatory cytokines (2018, NA)
• FoxO signaling pathway (2018, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Salmonella enterica subsp. enterica serovar Enteritidis,Escherichia coli O1,Gallus gallus,Anas platyrhynchos,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Gallid alphaherpesvirus 2)
• Notch pathway is regulated by short-range cell–cell signaling (2018, NA)
• Nrf2 protects stellate cells from Smad-dependent cell activation (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• O-GlcNAcylation regulates oxidative stress signaling pathways (2018, NA)
• Autophagy induced by nutrient and nutrition stresses via the mTOR and AMPK signal pathways (2018, Homo sapiens)
• Biochemical pathways leading to diabetic retinopathy (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• The neurogenic activity of (2R,6R)-hydroxynorketamine (2018, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Diaporthe sclerotioides,Venustaconcha ellipsiformis)
• Proposed model of PI3K signaling network in algae under N starvation based on relative gene expression in T411 and its unique physiology (2018, NA)
• Schematic model of miR-19b-mediated promotion of progression of breast cancer.Abbreviation: miR-19b, microRNA-19b (2018, Homo sapiens,Bos taurus)
• Antioxidants neutralize mitochondrial ROS (mtROS) (2018, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica,Mycobacterium leprae,Mus musculus,Rattus norvegicus,Candida dubliniensis,Vasconcellea candicans,Homo sapiens,Caenorhabditis elegans,Hepatitis B virus,NA)
• Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism (2018, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica,Mycobacterium leprae,Mus musculus,Rattus norvegicus,Candida dubliniensis,Vasconcellea candicans,Homo sapiens,Caenorhabditis elegans,Hepatitis B virus,NA)
• Tryptophan metabolism mediated immune cell response (2018, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica,Mycobacterium leprae,Mus musculus,Rattus norvegicus,Candida dubliniensis,Vasconcellea candicans,Homo sapiens,Caenorhabditis elegans,Hepatitis B virus,NA)
• The regulation of the anti-viral signaling pathway (2018, NA)
• Signalling pathways involved in ccRCC (2018, NA)
• TGFB1 signaling cascade leading to EMT (2018, Human gammaherpesvirus 4,Human immunodeficiency virus,Respiratory syncytial virus,Human papillomavirus type 16,Human betaherpesvirus 5,Measles morbillivirus,Human rhinovirus sp.,Transmissible gastroenteritis virus,Mus musculus,Rattus norvegicus,Escherichia coli,Pseudomonas aeruginosa,Homo sapiens,NA)
• Metabolic pathway of xylose in O (2018, NA)
• Triptolide downregulation of GADD45B expression in the protection of podocytes from apoptosis (2018, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Danio rerio,Oryzias latipes,Tripterygium wilfordii,Podocarpus latifolius,Homo sapiens)
• Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides and Incident Cardiovascular Disease (2018, NA)
• Low antiviral gene expressions at the time of antiretroviral therapy (ART) initiation in cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS) group (2018, Homo sapiens,Mycobacterium tuberculosis,Human immunodeficiency virus,Cryptococcus neoformans,Coeligena iris)
• Folate‐mediated one‐carbon metabolism, links to methylation reactions and nucleotide synthesis (by Cheng TY et al (2018, Homo sapiens)
• Neurotrophic signaling cascades (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Solanum lycopersicum)
• Regulated cell death signaling pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• The cyclin D1–CDK4/6–RB pathway in breast cancer.The role of the cyclin D1–CDK4/6-RB pathway in breast cancer cells, including cross talk with other oncogenic signaling pathways (2018, NA)
• Schematic drawing of epigenetic reprogramming in Dnmts, Sfrp4 and Wnt/B‐catenin pathway from the foetus to offspring (2018, NA)
• Dynamics of S1P- and ceramide-synthesis pathway (2018, NA)
• MiRNA and host targets are involved in common pathways (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• In vitro–transcribed guide RNAs trigger an innate immune response via the RIG-I pathway (2018, Bos taurus,Oryctolagus cuniculus,Equus asinus,Measles morbillivirus,Tobacco etch virus,Hepatitis delta virus,Homo sapiens,Mus musculus,Escherichia coli BL21,synthetic construct,NA,NA)
• Regulation of SREBP1 and lipid metabolism by oncogenic signaling (2018, NA)
• Potential pathway of Nrf2 inhibiting oxidative stress and inflammatory response (2018, Armoracia rusticana,PX clade,Haematococcus lacustris,Cinchona pubescens,Bryopsis pennata,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• PARP inhibitors: Some possible mechanisms of action and resistance (2018, Homo sapiens)
• Regulatory effects of androgen on TGFB1/Smad signaling pathway and Nrf2-ARE signaling pathway (2018, NA)
• Enriched target genes of the TFs TCF7, RUNX1, STAT3, and SOX4 in the MAPK signaling pathway (2018, NA)
• Cell cycle arrest induced fibrosis (2018, NA)
• Cell cycle pathway and common checkpoints (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries,Hepatitis B virus,Piper longum,NA)
• Platelet function and molecular targets of antiplatelet agents (2018, Diaporthe sclerotioides,Bikinia letestui,Carpinus caroliniana,Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Tropidolaemus wagleri)
• The “cross-talk” between purinergic receptors during the uridine triphosphate (UTP)-mediated control of Leishmania amazonensis infection (2018, Leishmania amazonensis,Homo sapiens)
• Triggering receptor expressed on myeloid cells 2 (TREM2) maintains microglial metabolism through the mammalian target of rapamycin (mTOR) pathway in Alzheimer’s disease (AD) (2018, NA)
• MAPK and PI3K/AKT/mTOR pathway interactions in melanocytic tumors (2018, NA)
• Mechanosignaling in normal keratinocytes and psoriasis (2018, NA)
• Estrogen (E2) activates IGF-1R pathway in adrenocortical carcinomas cells (2018, Homo sapiens)
• Major signaling pathways activated through IGF-1R and EGF-R in adrenocortical carcinoma (2018, Homo sapiens)
• Signaling pathway which miR-21 can regulate multiple functions in astrocytes (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• TNBC: The current and upcoming therapeutic strategies targeting the mutant proteins or pathways to enable tailored-therapeutics (2018, NA)
• STIM proteins in neutrophil functions (2018, NA)
• Signal transduction pathways involving c-fos (2018, NA)
• Hippo pathway (2018, NA)
• Mechanism of coagonism (2018, NA)
• HSPB5 pathways present in skeletal and cardiac muscle tissue (2018, Homo sapiens)
• Possible signaling mechanism for cigarette smoke and FGF23-mediated regulation of FGFR4/PLCG/calcineurin/NFAT pathway (2018, NA)
• MAPK heat diffusion sub-network: pathway extracted from the TieDIE subnetwork using heat diffusion analysis from the MAPK1 network node (2018, NA)
• The two co-occurring pathways in PDAC that are predicted to drive oncogenesis based on the mutational landscape representing two common driver pathways (2018, NA)
• Schematic illustrating the current working hypothesis on IFNT signaling in endometrial epithelia and stroma of the ovine uterus (2018, Sus scrofa,Ovis aries,Homo sapiens)
• Spleen regulatory networks (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Human alphaherpesvirus 1)
• SAM treatment during hepatocarcinogenesis (2018, Homo sapiens,Mus musculus,Harvey murine sarcoma virus)
• Graphical representation shows CHPV interacts with angiotensin II that leads to phosphorylation of PLCG (2018, Human immunodeficiency virus 1,unidentified influenza virus,H5N1 subtype,Enterovirus C,Chandipura virus,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Nicotiana tabacum,Simian-Human immunodeficiency virus)
• Proposed model for interplay between Smad1 and Smad3 in DN (2018, NA)
• FRMD8 stabilises the iRhom2/ADAM17 sheddase complex at the cell surface (2018, NA)
• Chlamydia and Lipids Engage a Common Signaling Pathway that Promotes Atherogenesis (2018, NA)
• Cell cycle in LNCaP cells after NETD (2018, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Human gammaherpesvirus 4,vectors)
• Whole exome sequencing identifies MRVI1 as a susceptibility gene for moyamoya syndrome in neurofibromatosis type 1 (2018, NA)
• Quercetin inhibits gastric cancer metastasis (2018, Armoracia rusticana,Allium cepa,Homo sapiens,Mus musculus,Bos taurus,Antarctothoa delta)
• Representative cartoon of opioid receptors distribution and expression in striosomes and matrix compartments of the dorsal striatum (2018, NA)
• Schematic presentation of JNK signaling pathway in myocardial ischemia/reperfusion injury (2018, Mus musculus,Rattus norvegicus,Salvia miltiorrhiza,Apium graveolens,Homo sapiens,Oryctolagus cuniculus)
• Schematic presentation of JNK signaling pathway in cerebral ischemia/reperfusion injury (2018, Mus musculus,Rattus norvegicus,Salvia miltiorrhiza,Apium graveolens,Homo sapiens,Oryctolagus cuniculus)
• Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors (2018, NA)
• Schematic model on the molecular cascade leading to tumor formation upon Jak/Stat activation in the embryonic hemocytes (2018, Drosophila melanogaster,Paracentrotus lividus,Manduca sexta,Leptopilina boulardi,Drosophila suzukii,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Malus domestica,vectors,Lactobacillus larvae)
• Oxidative stress survival and tumor growth suppression (2018, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Cauliflower mosaic virus)
• Network pathway: pathway enrichment analysis was performed (2018, NA)
• Schematic for alternative complement pathway activity in fHm/m/fP−/− mice (2018, NA)
• Taurine effects on protein catabolism (2018, NA)
• Apelin/APJ axis in AngII induced HUVECs ageing (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens)
• The planar cell polarity pathway (2018, Homo sapiens)
• WNT/Beta-catenin signal transduction pathway (2018, Homo sapiens)
• NETosis after Entamoeba histolytica engagement (2018, NA)
• Biosynthetic pathway and multifunctionality of the Pseudomonas quinolone signal (PQS) (2018, NA)
• MicroRNAs (miRNAs) regulate innate host immune response against influenza infection by targeting intracellular signaling pathways (2018, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,H7N9 subtype,Influenza A virus H3N2,Influenza A virus H1N1,H1N5 subtype,Mus musculus,Canis lupus familiaris,Sus scrofa,Cricetus cricetus,Homo sapiens,Caenorhabditis elegans,vectors,NA)
• Schematic diagram showing the role of Sulfatase-1 in inhibiting mesothelin expression in Carcinogenesis (2018, NA)
• IL-33 signaling (2018, NA)
• Mechanistic regulation of epithelial-to-mesenchymal transition through RAS signaling pathway and therapeutic implications in human cancer (2018, NA)
• RAS signaling cascade and EMT: Growth factors including EGF, FGF, HGF, VEGF, PDGF, IGF act through RTKs and activate PI3K–AKT, RAS-RAF-MEK-ERK MAPK and SRC signaling cascade (2018, NA)
• Schematic diagram illustrating the proposed signaling pathway involved in the inhibitory effects of CORM-2 on P (2018, NA)
• NRF2 and the hallmarks of cancer (2018, NA)
• Hypothetical model for the role of lncRNAs in rheumatoid diseases (2018, NA)
• Dysregulated genes and associated miRNAs in the KEGG TGFBeta-signaling pathway (2018, Homo sapiens,Mus musculus)
• RhoA/ROCK1/LIMK2/Cofilin signaling pathway (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Tim‐3 exacerbates kidney ischaemia/reperfusion injury through the TLR‐4/NF‐KB signalling pathway and an NLR‐C4 inflammasome activation (2018, NA)
• Proposed mechanisms by which transcription factor specificity protein 1 modulates TGFB1 production to negatively regulate RANTES expression in macrophages stimulated with substance P (2018, Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis,Prevotella sp.,NA)
• Cell cycle arrest and apoptosis of hepatocytes (2018, NA)
• Cholesterol and Bile Acid -Mediated Regulation of Autophagy in Fatty Liver Diseases and Atherosclerosis (2018, NA)
• Consequences of hepatic fructose metabolism (2018, NA)
• Design and proposed active mechanism for the intracellular protein delivery platform based on rod-like pure drug nanoparticles (PNPs) with cellular entry bypassing endo-lysosomes (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Eurema lisa)
• Functional mechanisms of lncRNAs in vascular disease (2018, NA)
• Butyrate suppresses colorectal cancer development (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Fusobacterium nucleatum,Faecalibacterium prausnitzii,Homo sapiens,Saccharomyces cerevisiae,gut metagenome)
• Gene network of the yeast data related to the cell cycle pathway via the JMCCM (2018, NA)
• Yeast cell cycle pathway from the KEGG database (2018, NA)
• KEGG pathway (FDR < 0.05) enriched by the 289 differentially expressed genes in drug group compared to model group (2018, Lycium barbarum,Rehmannia glutinosa,Lycium chinense,Dioscorea polystachya,Cuscuta chinensis,Dioscorea oppositifolia,Cornus officinalis,Cuscuta japonica,Cyathula officinalis,Mus musculus,Rattus norvegicus,Homo sapiens,Mauremys reevesii)
• Schematic diagram depicts the possible mechanism for the anti-inflammatory effect of TNS (2018, Angelica sinensis,Prunus armeniaca,Engelhardia roxburghiana,Gleditsia sinensis,Rhizophora mangle,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Common genes between enriched pathway sets of drugs and breast cancer (2018, NA)
• The positive feedback of CCL2 and SQSTM1 contributes to chemoresistance (2018, NA)
• ZIKV Env-induced cell cycle arrest and apoptosis in PC12 cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Dengue virus,Zika virus,Ebola virus sp.,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Aedes aegypti)
• Addition of PDC to fermentative pathways in cellulolytic microbes can add a metabolic shortcut (2018, Escherichia coli,Zymomonas mobilis,Acetivibrio thermocellus,Geobacillus stearothermophilus,Ruminiclostridium cellulolyticum,Caldicellulosiruptor bescii,Platanus racemosa,Thermoascus aurantiacus,Bos taurus,Homo sapiens)
• NFKB pathway induced by LaW37 in Caco-2 cells (2018, Lactobacillus acidophilus,Homo sapiens)
• Pectin oligosaccharides (POS) downregulates the expression of nuclear factor-kappa B (NFKB) and COX-2 by binding toll-like receptor 4 (TLR4) (2018, Arabidopsis thaliana,Diaporthe sclerotioides,Solanum tuberosum,Malus domestica,Panax ginseng,Camellia sinensis,Ginkgo biloba,Aspergillus niger,Ipomoea batatas,Citrus x paradisi,Pyricularia oryzae,Beta vulgaris subsp. vulgaris,Beta vulgaris,Citrus limon,Prunus domestica,Citrus reticulata,Cyamopsis tetragonoloba,Diospyros kaki,Passiflora edulis,Tamarindus indica,Crataegus pinnatifida,Rosa canina,Pleurotus eryngii,Thermoascus aurantiacus,Aconitum coreanum,Ulmus macrocarpa,Decalepis hamiltonii,Escherichia coli,Pseudomonas aeruginosa,Lactobacillus acidophilus,Escherichia coli O157H7,Bifidobacterium longum,Xanthomonas oryzae pv. oryzae,Bifidobacterium adolescentis,Phocaeicola vulgatus,Dickeya dadantii,Staphylococcus arlettae CVD059,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus 1,NA)
• Pectin oligosaccharides (POS) regulates STAT 1 and 3 signaling pathway by the leptin receptor (2018, Arabidopsis thaliana,Diaporthe sclerotioides,Solanum tuberosum,Malus domestica,Panax ginseng,Camellia sinensis,Ginkgo biloba,Aspergillus niger,Ipomoea batatas,Citrus x paradisi,Pyricularia oryzae,Beta vulgaris subsp. vulgaris,Beta vulgaris,Citrus limon,Prunus domestica,Citrus reticulata,Cyamopsis tetragonoloba,Diospyros kaki,Passiflora edulis,Tamarindus indica,Crataegus pinnatifida,Rosa canina,Pleurotus eryngii,Thermoascus aurantiacus,Aconitum coreanum,Ulmus macrocarpa,Decalepis hamiltonii,Escherichia coli,Pseudomonas aeruginosa,Lactobacillus acidophilus,Escherichia coli O157H7,Bifidobacterium longum,Xanthomonas oryzae pv. oryzae,Bifidobacterium adolescentis,Phocaeicola vulgatus,Dickeya dadantii,Staphylococcus arlettae CVD059,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus 1,NA)
• Pectin oligosaccharides and MAPK/ERK signaling pathway (2018, Arabidopsis thaliana,Diaporthe sclerotioides,Solanum tuberosum,Malus domestica,Panax ginseng,Camellia sinensis,Ginkgo biloba,Aspergillus niger,Ipomoea batatas,Citrus x paradisi,Pyricularia oryzae,Beta vulgaris subsp. vulgaris,Beta vulgaris,Citrus limon,Prunus domestica,Citrus reticulata,Cyamopsis tetragonoloba,Diospyros kaki,Passiflora edulis,Tamarindus indica,Crataegus pinnatifida,Rosa canina,Pleurotus eryngii,Thermoascus aurantiacus,Aconitum coreanum,Ulmus macrocarpa,Decalepis hamiltonii,Escherichia coli,Pseudomonas aeruginosa,Lactobacillus acidophilus,Escherichia coli O157H7,Bifidobacterium longum,Xanthomonas oryzae pv. oryzae,Bifidobacterium adolescentis,Phocaeicola vulgatus,Dickeya dadantii,Staphylococcus arlettae CVD059,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus 1,NA)
• Repair of DSBs by the microhomology-mediated end-joining pathway (2018, Homo sapiens)
• Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage (2018, NA)
• Endothelial and smooth muscle-mediated mechanisms of vascular dysfunction in shock (2018, Homo sapiens)
• Molecular mechanism of apoptosis and necroptosis (2018, NA)
• Lactate activating the NFKB signaling pathway following intracerebral hemorrhage (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Signaling for apoptosis and carcinogenesis pathway differentiation (2018, NA)
• An overview of the cannabinoid type 2 (CB2) receptor system and its therapeutic potential (2018, Cannabis sativa,Cannabis sativa subsp. indica,Cannabis ruderalis,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Simian immunodeficiency virus)
• Proposed model illustrating the role of xanthatin and its mechanism in angiogenesis (2018, NA)
• Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) (2018, NA)
• Transcriptome study on Macrobrachium nipponense hepatopancreas experimentally challenged with white spot syndrome virus (WSSV) (2018, NA)
• MicroRNA molecular profiling identifies potential signaling pathways conferring resistance to chemoradiation in locally-advanced rectal adenocarcinoma (2018, NA)
• Engagement between the gut immune system and a probiotic (exemplified by Bifidobacterium longum subsp (2018, Bifidobacterium longum,Bifidobacterium longum subsp. longum,Homo sapiens)
• Cross-talk between tumor, MDSCs and immune cells for development of HPV-related carcinogenesis (2018, Human papillomavirus,Human papillomavirus type 16,Alphapapillomavirus 7,Homo sapiens,Mus musculus)
• LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs (2018, NA)
• Interaction among MCP-1/CCR2 signaling, TLR4, and GSK3B in ethanol-induced neuroinflammation (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Inflammation leads through PGE/EP 3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes (2018, NA)
• Canonical and non-canonical signaling of interferon-gamma (2018, NA)
• EE2 and LNG affected the phosphorylation of proteins involved in brain development, synaptic plasticity, neurogenesis, synaptic transmission, and calcium ion homeostasis although the specific phosphorylation profiles varied (2018, NA)
• Hedgehog pathway in nonalcoholic fatty liver disease (2018, NA)
• Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients (2018, Homo sapiens,Mus musculus,clinical samples)
• Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance (2018, Homo sapiens,Mus musculus,Bos taurus,Matthiola incana,Papaya ringspot virus)
• The anti-inflammatory effects of MPQP on the LPS-induced inflammatory pathway (2018, Panax ginseng,Codonopsis lanceolata,Blainvillea acmella,Thunbergia alata,Homo sapiens,Mus musculus)
• Schematic/pathway representation of the FOXO‐p53 interplay in cellular senescence (2018, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Summary and model for the potential function of the chIL-34 signaling pathway (2018, NA)
• Lead (Pb2+)-induced activation of the IL-8 gene (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Diaporthe sclerotioides,Listeria monocytogenes,Pollachius pollachius)
• Signaling pathways involved in the downregulation of NPC2 in HSCs (2018, NA)
• ATM-dependent DNA Damage Response (2018, NA)
• Phoenixin-20 stimulates the mRNA expression of GnRH, GnRH receptor, Kiss1 peptide, and GRP173 via the cAMP-PKA pathway and CREB phosphorylation mediated by the GPR173 (2018, NA)
• Neuromuscular junction and congenital myasthenic syndromes (2018, NA)
• The tumor microenvironment on myeloid cell differentiation and metabolism (2018, Homo sapiens,Mus musculus,Candida dubliniensis,NA)
• Canonical and non-canonical Stat3 signaling pathways (2018, Homo sapiens,Mus musculus,Bos taurus)
• Regulatory mechanisms of selected modifications in PPARG (2018, NA)
• Schematic showing that the cytotoxic effect of NSC 95397 on colon cancer cells is activated by inhibiting MKP-1 activity followed by ERK1/2 activation (2018, NA)
• The cooperation of Src and oncogenic Ras in tumourigenesis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Gallus gallus,Matthiola incana,Rous sarcoma virus)
• Ingenuity pathway analysis of ALX4 genes and antidepressant genes based on treatment response in MDD (2018, NA)
• Arsenic Trioxide and Thalidomide on Angiogenesis and VEGF in Leukemia (2018, NA)
• CS negatively regulates IL-1B secretion in murine macrophages (2018, NA)
• Signaling pathway mediated by OX1R–kappa opioid receptor (KOR) heterodimers (2018, Bos taurus,Canis lupus familiaris,Sus scrofa,Felis catus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Danio rerio,Macaca mulatta,Porzana carolina)
• Schematic describing the proposed role of MYC and CDKN1A in Wnt/Beta-catenin (CTNNB1) and angiopoietin pathway-dependent hyaloid vessel regression (2018, Homo sapiens)
• Regulatory mechanisms for alternative splicing impact numerous components of the CME (2018, Homo sapiens)
• Putative model of the functions of HSPGs in CRC cells (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Interactive KEGG diagram for Signaling pathways regulating pluripotency of stem cells (2018, NA)
• Pathway relationship network (2018, Homo sapiens,Nicotiana tabacum,Helicobacter pylori)
• The effects of the Insulin-like Growth Factor 1 (IGF-1) on muscle growth and homeostasis (2018, NA)
• EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival (2018, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Role of NUAK1 in anti-oxidant signalling (2018, NA)
• Hypothetical model showing that imbalanced LIMK1 and LIMK2 expression activates the WNT/Beta-catenin pathway and leads to CRC progression and EMT-induced metastasis (2018, NA)
• Central carbon metabolism in cancer (2018, Homo sapiens,Rattus norvegicus,Bos taurus)
• Combined network analysis of metabolites and lipids (2018, Homo sapiens,Rattus norvegicus,Bos taurus)
• SOX17-mediated disruption of Wnt/beta-catenin signaling (2018, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human papillomavirus)
• H2S targets key host factors and viral steps to perturb replication of enveloped RNA viruses (2018, Ebola virus,Human immunodeficiency virus 1,Hepatitis B virus,Adenoviridae,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,Human gammaherpesvirus 8,Coxsackievirus B3,H3N2 subtype,Rift Valley fever virus,Human metapneumovirus,Tick-borne flavivirus,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Bacillus anthracis,Escherichia coli IS1,Mycolicibacterium smegmatis,Mycobacterium tuberculosis SP1,Mycoplasmopsis fermentans,Desulfovibrio desulfuricans,Chromatiaceae,Klebsiella pneumoniae IS10,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Caenorhabditis elegans,Gallus gallus,NA,NA)
• IGF signaling pathway in pulmonary fibrosis (2018, NA)
• IGF signaling pathway (2018, NA)
• Multiple roles of the extracellular matrix (ECM) in modulating the cancer-immunity cycle (2018, NA)
• Working model of the mechanistic interaction of miR-335-5p and CPNE1 in the control of the EGFR signaling pathway: miR-335-5p regulates CPNE1 expression via EGFR signaling in NSCLC (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Bucephala clangula)
• Nm23-H1 participating in multiple steps of DSBR pathway (2018, NA)
• Cancer-related pathway-pathway relationships (2018, Escherichia coli,Pseudomonas aeruginosa,Bacillus subtilis,Pseudomonas aeruginosa PAO1,Homo sapiens)
• Examples of well-characterized signaling pathways contain numerous predicted short linear motifs (2018, NA)
• Central carbon and nitrogen metabolism of Arabidopsis thaliana active in most growth stages and conditions simulated (2018, NA)
• Wnt antagonist and secreted frizzled-related protein 5: implications on lipid metabolism, inflammation, and type 2 diabetes mellitus (2018, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Hepatitis B virus)
• Compound–target–pathway subnetwork of 12 compounds relating to AD (2018, Panax ginseng,Scutellaria baicalensis,Melia azedarach,Wolfiporia cocos,Fallopia multiflora,Polygala tenuifolia,Acorus tatarinowii,Conchocarpus fontanesianus,Ficus hirta,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Sub-network with a size cut-off of 28 between D-glucose and L-phenylalanine in S (2018, Escherichia coli,Escherichia coli K-12,Pseudomonas putida,Lactococcus lactis,Pseudomonas putida KT2440,Ruminiclostridium cellulolyticum,Desulfovibrio vulgaris,Geobacter sulfurreducens,Haemophilus influenzae Rd KW20,Saccharomyces cerevisiae,Homo sapiens)
• Model of MAPK signaling pathway in MAP3K1; MAP2K4 wild-type or mutant cells (2018, Homo sapiens,Mus musculus,Bos taurus)
• TMUB1 and the calcium ion signaling pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Lima lima)
• Schematic overview of the pathway linking IMMP2L to senescence (2018, NA)
• Insulin biosynthesis and secretion (2018, NA)
• TRIMming TGFB signals in Th17 cells (2018, NA)
• Revisiting antipsychotic drug actions through gene networks associated with schizophrenia (2018, Homo sapiens,Rattus norvegicus)
• Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment (2018, NA)
• Primary mechanisms by which AIBP protects against macrophage inflammatory response (2018, NA)
• Oncogenic and tumor suppressive activities of ETS proteins (2018, NA)
• Innate immune responses to trauma (2018, NA)
• Regulation of innate and adaptive immunity by hypoxia and HIF signaling pathway (2018, Homo sapiens,Mus musculus,Danio rerio)
• Unfolded protein response and NFKB signaling (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Thapsia garganica,Homo sapiens,Gallus gallus,Human coronavirus 229E,NA)
• Chronic active BCR signaling in lymphoid malignancies (2018, Helicobacter pylori)
• Oncogenic MyD88 mutations activate the canonical NFKB pathway (2018, Helicobacter pylori)
• Noncanonical NFKB signaling pathway (2018, NA)
• Global view and function analysis of the ceRNA network in GC (2018, NA)
• Main signaling pathways of adiponectin in healthy liver (2018, NA)
• Pathway overview of Salmonella carbon metabolism under Pi starvation (2018, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Escherichia coli O157H7,Salmonella sp. WT,Mus musculus,Diaporthe sclerotioides,Homo sapiens)
• CAMP signaling in mammalian cells (A) vs (2018, NA)
• Genotoxic stress signaling pathway (2018, NA)
• TCR signaling pathway (2018, NA)
• RIG-I/MAVS signaling pathway (2018, NA)
• Nod1/2 signaling pathway (2018, NA)
• IL-1BR1 signaling pathway (2018, NA)
• TNF-R1 signaling pathway (2018, NA)
• Metabolic activation of aristolochic acid I (AA-I), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 5-methylchrysene, and tamoxifen are shown as prototypes of procarcinogens (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Nicotiana tabacum,Human papillomavirus types)
• Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Reactions and enzymes of proline metabolism in higher organisms (2018, Escherichia coli,Thermus thermophilus,Deinococcus radiodurans,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Human immunodeficiency virus 1)
• Pathway by which Pg-C-EE inhibits melanogenesis and ROS generation (2018, NA)
• Implication of the Kallikrein-Kinin System in Neurological Disorders: Quest for Potential Biomarkers and Mechanisms (2018, NA)
• Roles of IGF2BP1 in promoting and suppressing tumor growth and invasion via regulating different mRNA targets, under the modulation of upstream non-coding RNAs (2018, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster)
• Differential phospho-Smad signals between tumor suppression and fibrocarcinogenesis (2018, NA)
• JMY in p53 Regulation (2018, Homo sapiens,Mus musculus)
• Schematic diagram showing the mechanism of action of TFs against LPS-induced acute liver injury (2018, NA)
• IDH pathway and targets in acute leukemia (2018, NA)
• Metabolic pathways influenced by transcriptional factor O-GlcNAcylation (2018, NA)
• HBP modulates cancer metabolism through the O-GlcNAcylation (2018, NA)
• ER stress and the UPR in insulin resistance and diabetes (2018, Homo sapiens)
• P14ARF-p53 pathway (2018, NA)
• Outline of the three main pathways of colon carcinogenesis (2018, NA)
• Testis germ cell apoptosis via SIRT1 signaling pathway (2018, NA)
• Hepatic cell death pathway and liver injury in response to high fat diet exposure (2018, NA)
• Mechanisms of innate and acquired resistance to immune-checkpoint inhibitors (ICPIs) (2018, Homo sapiens,Mus musculus,gut metagenome,Akkermansia muciniphila)
• IL-37-mediated intracellular signaling cascades in eosinophils for the suppression of allergic airway inflammation (2018, NA)
• The BMP signaling cascade in osteoblast differentiation (2018, NA)
• Regulatory Network and Crosstalk Analysis for Gene Set(A) KEGG pathway network formed by relapse gene sets (2018, Homo sapiens,Mus musculus,Bos taurus,vectors,Venustaconcha ellipsiformis)
• Apoptosis signaling pathway and its control by phosphorylation (2018, Homo sapiens)
• Control of the PI3K and RAS signaling pathways by phosphatase signaling (2018, Homo sapiens)
• Metabolic mechanisms of exercise-induced cardiac growth (2018, NA)
• Neuroprotection and the PI3K/AKT/PTEN/GSK-3B pathway and SODs (2018, NA)
• Illustration showing presumed mechanisms mediating suberoylanilide hydroxamic acid (SAHA)-induced autophagy (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Autophagy and apoptosis mediated by the cytoplasmic activity of p53 protein under basal conditions (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Autophagy, apoptosis, and cell cycle arrest mediated by the activity of nuclear p53 protein (p53) in its function as a transcription factor in stress conditions (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• The role of mitogen-activated protein kinase–extracellular receptor kinase pathway in female fertility outcomes: a focus on pituitary gonadotropins regulation (2018, Homo sapiens)
• Schematic activation of extracellular-signal-regulated kinase 1/2.In response to extracellular stimuli, a kinase cascade is activated which leads to ultimate activation of ERK1/2 (2018, Homo sapiens)
• Subnetworks of breast cancer subtypes (2018, NA)
• Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants (2018, NA)
• Pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants (2018, NA)
• Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer (2018, NA)
• Regulatory functions of oncogenic and tumor suppressor miRNAs on canonical Wnt signaling pathways in HCC (2018, NA)
• Working model proposed for the synergistic action of GH and insulin on IGF-I and -II expression in the carp liver (2018, Gallus gallus,Danio rerio,Oncorhynchus mykiss,Cyprinus carpio,Oryzias latipes,Carassius auratus,Salmo trutta,Ctenopharyngodon idella,Oncorhynchus kisutch,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Matthiola incana)
• Interaction of LBR, Rab5, Nup205, and NXF1 in the PI3K/mTOR/AKT signaling pathway (2018, Hepatitis B virus,Influenza A virus,unidentified influenza virus,Dengue virus,Orthomyxoviridae,H1N1 subtype,West Nile virus,H5N1 subtype,H7N9 subtype,Influenza A virus H3N2,Saccharomyces cerevisiae,Matthiola incana,Neurospora crassa,Bos taurus,Canis lupus familiaris,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Pathway mechanisms underlying CHMs improve lipid metabolism in liver cells (2018, NA)
• Molecular mechanism model for lncRNAs involved in the tumorigenesis of human TNBC (2018, Homo sapiens)
• Pyruvate carbon flux tugging strategies for increased 2,3-butanediol (2,3-BDO) production and reduced ethanol subgeneration in yeast (2018, Saccharomyces cerevisiae,Homo sapiens)
• Mechanisms involved in osteocyte mechanotransduction (2018, NA)
• Signaling pathways of M3R regulates proliferation of urothelium (hypothesis based on previous reports) (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,Merluccius merluccius)
• Production of IL-32 and its downstream signaling network (2018, NA)
• Synovial cell metabolism and chronic inflammation in rheumatoid arthritis (2018, NA)
• Estrogen signaling pathway (2018, NA)
• Regulation of the synaptic vesicle cycle pathway by SE in OVX with (CES)/without (COS) E2-replacement with respect to their non-SE counterparts (CEN and CON) (2018, NA)
• Schematic describing invariant natural killer T (iNKT) cell development and function in the thymus (2018, NA)
• Metabolic reconstruction of LSUCC0530 (2018, Escherichia coli,Escherichia coli IS1,Cupriavidus necator H16,Candidatus Pelagibacter ubique,Candidatus Pelagibacter ubique HTCC1062,Candidatus Pelagibacter sp. IMCC9063,Candidatus Fonsibacter ubiquis,metagenomes,uncultured marine bacterium,environmental samples,unidentified marine bacterioplankton,Bacteriophage sp.,Psidium guajava,Aphis glycines)
• Sema4D/Plexin-B1 signaling (2018, NA)
• Macrophage Phenotype in Regulating the Response to Radiation Therapy (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Flakea papillata,Homo sapiens,Canis lupus familiaris,Pseudomonas aeruginosa,Mouse mammary tumor virus,Anavitrinella pampinaria)
• The mevalonate pathway and statin mechanism (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Echinochloa frumentacea)
• Signaling pathways for flaccidoxide-13-acetate in bladder cancer (2018, NA)
• Multidrug resistance in chronic myeloid leukemia (2018, NA)
• The above-mentioned findings (2018, Oryctolagus cuniculus,Capra hircus,Pekania pennanti,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Insulin signaling cascades regulate GLUT4 trafficking (2018, NA)
• Therapeutic targets in the Notch signaling pathway (2018, Drosophila melanogaster,Paracentrotus lividus,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Proposed mechanism demonstrates a diagram of the CREB signaling pathway stimulated by melatonin in HT-22 cells (2018, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• Elaiophylin inhibits tumor angiogenesis (2018, NA)
• Mechanisms behind low levels of hepcidin in liver disease (2018, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Hepatitis B virus,Homo sapiens,NA)
• CLL main pathogenic pathways and target agents against BTK, PI3K and Bcl-2 (2018, NA)
• Herpesvirus-encoded microRNAs detected in human gingiva alter host cell transcriptome and regulate viral infection (2018, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human alphaherpesvirus 2,Saccharomyces cerevisiae,Escherichia coli,Armoracia rusticana,Sequoia sempervirens,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Homo sapiens,Mus musculus,Bos taurus,clinical samples,NA)
• Camalexin biosynthesis pathway and regulatory gene expressed by MAPK cascade designed using cell designer tool (2018, NA)
• The two faces of pannexins: new roles in inflammation and repair (2018, NA)
• Proposed model of mode of action of M (2018, NA)
• Pathway linked to ER stress (2018, Mus musculus,Rattus norvegicus,Clostridioides difficile,Clostridioides difficile CD3,Homo sapiens,Oryctolagus cuniculus,gut metagenome)
• CAMKK2 as a molecular hub downstream in the bone–prostate cancer (PCa) microenvironment (2018, Homo sapiens,Mus musculus,clinical samples)
• SHP2 plays a key role in NSC proliferation, differentiation, and migration (2018, Homo sapiens,Mus musculus)
• SHP2 regulates mesenchymal stem cells (2018, Homo sapiens,Mus musculus)
• Domains and functions of MCPyV T antigens (2018, NA)
• Dysfunctional cellular mechanisms in PD (2018, NA)
• Schematic describes the major developmental steps that underlie the differentiation of preskeletal mesenchymal cells toward endochondral (right) and intramembranous (left) ossification (2018, NA)
• Schematic demonstrating of [U‐13C]glucose to CAC and PPP, and protein expression levels in HBP (2018, Bos taurus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• KRAS Activating Signaling Triggers Arteriovenous Malformations (2018, NA)
• The Wnt signaling pathway (2018, NA)
• Impact of PI3K inhibitors on breast cancer cell and its tumor microenvironment (2018, NA)
• GO enrichment of the highest score sub-modules (2018, NA)
• A schematic for ginseng compatibility environment mediated cardiotoxicity-attenuated effect by the crosstalk of PKA and Epac signaling axis (2018, Mus musculus,Rattus norvegicus,Armoracia rusticana,Cavia porcellus,herbal medicine,Panax ginseng,Homo sapiens,Oryctolagus cuniculus)
• “threshold model”, as exemplified by the FGF8-FGFR system, can explain disparities in transcriptional activity (2018, NA)
• Acquisition of cell identity in the female gametophyte (2018, NA)
• Activation of the anticipatory unfolded protein response by estrogen receptor A (ERA) (2018, Homo sapiens,Mus musculus)
• Pathway activation after damage-associated molecular patterns (DAMPs) stimulation (2018, NA)
• STRING pathway analysis of up- and downregulated genes in MDA-MB-231 cells co-cultured with adipocytes (2018, Homo sapiens,Macaca mulatta,Mus musculus)
• Direct effects of thyroid hormones on hepatic lipid metabolism (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Candida dubliniensis)
• Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Complexes formed by mutant p53 and their roles in breast cancer (2018, Homo sapiens,Mus musculus,prion)
• The Keap1/Nrf2 pathway and its epigenetic modification by SFN (2018, Brassica oleracea,Angelica sinensis,Homo sapiens,Mus musculus)
• Integration of mRNA data and CNAs profiles: BMD+DAD-screening network using Coxnet (top) and ADMMnet (bottom) methods with mRNA expression data and the integration of mRNA data and CNAs profiles (2018, Homo sapiens)
• mRNA expression data: BMD+DAD-screening network using Coxnet (left) and ADMMnet (right) methods with mRNA expression data and the integration of mRNA data and CNAs profiles (2018, Homo sapiens)
• Schematic overview of Nrf2 signalling crosstalk to both Wnt3a/B‐catenin and AMPK pathway in COPD/emphysema (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model of the mechanism that links mitochondrial dysfunction and insulin resistance in non‐alcoholic steatohepatitis (2018, NA)
• Genes predicted to increase cardiovascular angiogenesis are strongly up‐regulated by CpG pre‐conditioning 24 h post‐I/R (2018, NA)
• Schematic summary to test for dependence of IP-1 toxicity on cell cycle arrest (2018, Saccharomyces cerevisiae,Matthiola incana,Eucalyptus intertexta,Saccharomyces cerevisiae BY4741,Homo sapiens,Mus musculus)
• Paradigm describing how differences in MAPK signaling lead to inter-individual variability in phBEC ozone-mediated IL-8 induction (2018, Homo sapiens,Mus musculus,Armoracia rusticana)
• ML141-induced hepatocyte differentiation (2018, Bos taurus,Capra hircus,Equus asinus x Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Macaca mulatta,Mouse mammary tumor virus,Armoracia rusticana,NA)
• Metabolic Reprogramming in Kidney Cancer (2018, Homo sapiens,Mus musculus)
• Wnt signalling pathway.Left: the Wnt pathway is activated by the interaction between LRP5/6, Wnt and Frizzled (2018, Homo sapiens)
• CHIP in the modulation of EMT in CRC (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,clinical samples,murine stem cell retroviral vector)
• Proposed cellular mechanisms involved in insulin-stimulated androgen biosynthesis, PCOS-associated defects, and free fatty acid-induced insulin resistance and androgen production, together with AT2R and PPARG actions (2018, NA)
• Insulin signaling also controls mTOR pathway that inhibits autophagy (2018, Homo sapiens)
• Energy homeostasis and mitophagy in metabolic signature of M1 and M2 polarization (2018, NA)
• Reaction scheme of the metabolic sub-model (2018, NA)
• Synthetic biology-inspired genetic circuits for caffeine-induced gene expression (2018, NA)
• Different Wnt signaling pathways (2018, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes (2018, NA)
• Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,Xenopus laevis,Condylura cristata)
• The proposed signaling pathway for actin polymerization-mediated vasoconstriction after chronic hypoxia (CH) (2018, Rattus norvegicus,Homo sapiens)
• Potential mitochondrial derangements that may be present in pulmonary hypertension are many and varied (2018, NA)
• Proximity of Bcl-xl to p38, MK2, and RTN4 in platelet function (2018, NA)
• Network interactions of transcription factors predicted to be upstream of differentially expressed skeletal muscle genes (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Human immunodeficiency virus 1,Diaporthe sclerotioides)
• Activation of ERK results in negative feedback regulation of pathway activation by direct phosphorylation of upstream components of the pathway, namely MEK1, B-Raf and C-Raf, and Sos (2018, NA)
• Schematic showing the activation of the Ras to ERK pathway by growth factor binding to a receptor tyrosine kinase (2018, NA)
• XIAP regulates apoptotic and inflammatory signaling pathways (2018, NA)
• CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia (2018, NA)
• Diagram showing effects of 4-HNE on Keap1- and GSK3Beta-mediated Nrf2 degradation (2018, NA)
• Role and molecular pathway of IL-32 in cancer (2018, NA)
• BMP2/4 increase neurogenesis from adult hippocampal NSPCs and synergize with WNT3A (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• The intramitochondrial iron–sulfur cluster biosynthesis pathway (see text for details) (2018, NA)
• PI3K–AKT pathway perturbation in response to treatment of interleukin (IL)-6 stimulated osteoblasts with resolvin E1 (RvE1) (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Aggregatibacter actinomycetemcomitans)
• Resolvin E1 Promotes Bone Preservation Under Inflammatory Conditions (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Aggregatibacter actinomycetemcomitans)
• SIRT2 and RAS/ERK/JNK/MMP-9 pathway in gastric cancer (2018, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Homo sapiens,Mus musculus,Hepatovirus A)
• Plasmatic membrane toll-like receptor expressions in human astrocytomas (2018, NA)
• Defective identified pathways in immunodeficiencies predisposing to high susceptility to Epstein–Barr virus (EBV)-driven B-cell lymphoproliferative diseases (2018, NA)
• Role of Glial Immunity in Lifespan Determination: A Drosophila Perspective (2018, NA)
• Signaling pathways involving the MAPKs Fus3 and Kss1 (2018, NA)
• Binding of S100A8/A9 to toll-like receptor (TLR) 4 triggers the MyD88-dependent pathway, appearing to play a vital role in inflammation (2018, NA)
• Crucial biological functions of CCL7 in cancer (2018, Human immunodeficiency virus 1,West Nile virus,Measles morbillivirus,H-1 parvovirus,Replication competent viruses,Minute virus of mice,Matthiola incana,Cryptococcus neoformans,Komagataella pastoris,Cladophora subtilissima,Mus musculus,Rattus norvegicus,Listeria monocytogenes,Helicobacter felis,Homo sapiens,Caenorhabditis elegans)
• Schematic illustration of the proposed effects of SrRn on MDPs (2018, NA)
• The spatio-temporal cell dynamics of the G-protein/Pth11 and cAMP-signaling pathway during surface sensing and appressorium morphogenesis (2018, NA)
• Signalling pathways involved in the intervention effects of PZC, PZD and PZE on TIF (2018, Mus musculus,Wolfiporia cocos,Homo sapiens)
• Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming (2018, NA)
• Biosynthetic pathway for SGAs in tomato, cultivated eggplant, and other Solanum species (2018, NA)
• Luteolin-mediated extrinsic and intrinsic apoptosis in breast cancer.Notes: Illustration abridging the involvement of luteolin (green) in purposed apoptotic pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Corynephage beta)
• Luteolin inhibition of receptor-mediated tumor progression.Notes: Involvement of luteolin (green) in modifying processes necessary for metastasis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Corynephage beta)
• Interaction between oncogenic signaling and lipid desaturation in CSCs (2018, NA)
• Canonical and non-canonical NFKB signaling pathways (2018, Homo sapiens,Mus musculus)
• B cell receptor signaling pathway (2018, Homo sapiens,Mus musculus)
• Liver kinase B1 (LKB1) and CaMKKB/AMPK pathway (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Olea europaea)
• Signaling pathways in mast cell biology (2018, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Model depicts the multiple mechanisms by which NXT inhibits the development of diabetic nephropathy in db/db mice (2018, herbal medicine,Cistanche tubulosa,Swertia punicea,Liriope spicata,Liriope spicata var. prolifera,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Estrogen receptor (ER) signalling pathway (2018, NA)
• Role of DKK4 in different signal pathway (2018, NA)
• Salivary Exosomes: Emerging Roles in Systemic Disease (2018, NA)
• Functional networks in mucinous type epithelial ovarian cancer (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Working model for the actions of HDAC1/2 in the regulation of nephrogenesis (2018, NA)
• ʟ-Ornithine biosynthesis metabolic pathways in C (2018, Corynebacterium glutamicum,Corynebacterium glutamicum S9114,Homo sapiens)
• The proposed model for PI3K/Rac1/JNK/c-Jun pathway activation and involvement of BAG3 as a target of the PEITC effect (2018, Armoracia rusticana,Brassica oleracea,Nasturtium officinale,Corylus avellana,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• Integration of actions of PKD1 and PKD3 in cardiac energy metabolism—a hypothetical scheme (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Reactive oxygen species (ROS) produce oxidative stress which in return converts the normal epithelium to early adenoma which leads to the next stage that is intermediate adenoma by the activation of EGFR signaling (2018, Homo sapiens,Rattus norvegicus)
• Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma (2018, Canis lupus familiaris,Glycine max,Paraechinus aethiopicus,Solanum nigrum,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma (2018, Canis lupus familiaris,Glycine max,Paraechinus aethiopicus,Solanum nigrum,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma (2018, Canis lupus familiaris,Glycine max,Paraechinus aethiopicus,Solanum nigrum,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Proposed crosstalk pathway between A2AR signaling and Semas (2018, Mus musculus,Homo sapiens)
• Proposed substrates for LTP in the LPP (2018, NA)
• Hypotheses of dysfunctional regulation mechanisms of gastric carcinogenesis around XBP1 (2018, Homo sapiens,Helicobacter pylori,Venustaconcha ellipsiformis)
• INS-INSR and IRS-PI3K interactions in insulin signaling (a), and the effect of SOCS on insulin signaling (b) (2018, Homo sapiens)
• Interaction between adiponectin and GLUT4 in the adipocytokine signaling pathway (2018, Homo sapiens)
• Toll-like receptor (TLR) 4 signaling pathway (2018, NA)
• Tryptophan breakdown metabolic pathway in immune challenges (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• IRE1A regulates the immune function through various mechanisms including both its kinase (A) and RNase (B) functions (2018, NA)
• IRE1A structure and its downstream mechanisms in mild and severe stress (2018, NA)
• PLATELET LIFELINE TO CANCER: CHALLENGES AND OPPORTUNITIES (2018, NA)
• Networks involved in the analyses involving males with nPFOS exposure (2018, NA)
• Requirement of the Arf6-based mesenchymal pathway in both mesenchymal-type and amoeboid-type cancer invasion (2018, NA)
• P-Rex1 acts as a convergence point for pro-oncogenic/metastatic pathways (2018, NA)
• Mst homo- and heterodimers (2018, Homo sapiens)
• Main pathway targeted using siRNA delivery systems in oral cancer.Notes: Examples of siRNA therapeutics alter multiple hallmarks applied for oral cancer (2018, NA)
• Molecular signaling pathways involved in astrocyte reaction in AD (2018, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Melia azedarach,Non-A non-B hepatitis virus,Salvelinus neiva)
• Of Pleiotropy and Trajectories: Does the TGFB Pathway Link Childhood Asthma and COPD? (2018, Homo sapiens)
• Multiscale networks identified within neurons contain neuron-specific modules (2018, prion,unidentified,Homo sapiens,Mus musculus)
• Pathways altered in brain metastases compared to primary NSCLC (2018, NA)
• Comparison of the LC3-conjugation pathway during canonical autophagy and Plasmodium-associated autophagy-related (PAAR) response (2018, Plasmodium falciparum,Plasmodium berghei,Plasmodium vivax,Plasmodium yoelii,Plasmodium sp. P36,Mus musculus,Rattus norvegicus,Homo sapiens,Salmonella enterica subsp. enterica serovar Typhimurium)
• DMix regulates hepatic gluconeogenesis in diabetic rats via the PI3K/Akt signaling pathway (2018, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,earthworms)
• Both mTOR and eIF4E phosphorylation are needed for polysomal recruitment of terminal oligopyrimidine messenger RNAs (TOP mRNA) (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Scheme of PI3K/Akt/mTOR pathway depicting both complexes mTOR protein takes part in, mTORC1 and mTORC2 (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Excitatory toxicity model of methamphetamine (2018, NA)
• Specific microRNAs (miRNAs) in T helper 17 (Th17) cell differentiation and targets for current treatments (2018, NA)
• Inhibition of TGFB-induced EMT in breast cancer cells by blocking the ERK/NFKB/Snail signaling (2018, NA)
• Summary of the speculative roles of UNC5C in AD pathogenesis (2018, NA)
• PI3K/AKT/mTOR pathway in promoting cellular growth (2018, NA)
• ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Coregonus peled,Eleusine coracana subsp. coracana)
• Schema of signaling pathway involved in HSP60-mediated NLRP3 inflammasome activation and subsequent IL-1B production (2018, NA)
• Anabolic Androgenic Steroids in Discrete Areas of the Central Nervous System (2018, NA)
• Reconstruction of metabolic pathway of Woesearchaeota in the central carbon (a) and comparison of genes relating to the ferredoxin-dependent pathways between organisms from oxic and anoxic biotopes (b) (2018, NA)
• DYSREGULATION OF mRNA TRANSLATION AND ENERGY METABOLISM IN CANCER (2018, NA)
• Cyclooxygenase pathway of the arachidonate cascade (2018, herbal medicine,Camellia sinensis,Catharanthus roseus,Papaver somniferum,Aloe vera,Cinchona pubescens,Rauvolfia serpentina,Atropa belladonna,Digitalis purpurea,Cinchona officinalis,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Pasteurella multocida)
• Schematic overview of the pathway linking IMMP2L to senescence (2018, NA)
• Recycling endosome and bacterial pathogens (2018, NA)
• Cumulative HLA class I and APM defects across gliomas from TCGA (2018, Homo sapiens,Mus musculus)
• Commonalities in epileptogenic processes from different acute brain insults. Does it translate? (2018, NA)
• Innate Antiviral Immunity in the Skin (2018, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human papillomavirus,Dengue virus,Human papillomavirus type 16,H1N1 subtype,Vaccinia virus,Zika virus,West Nile virus,Human alphaherpesvirus 3,Dengue virus type 2,Variola virus,Merkel cell polyomavirus,Modified Vaccinia Ankara virus,Human parvovirus B19,Staphylococcus aureus,Staphylococcus epidermidis,Homo sapiens,Mus musculus,Gallus gallus,NA,NA)
• Regulation of lipid metabolism in cancer cells (2018, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens)
• Putative signaling pathway composed of FOXM1, MYC and miR-34a (2018, Homo sapiens,Mus musculus)
• Simplified schematic diagram of the pathways described in this study (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Olea europaea,Homo sapiens,Mus musculus)
• Gene clusters identified via gene interaction analysisLines indicate a physical interaction, as assigned by the GeneMANIA plugin for Cytoscape (2018, Homo sapiens,Diaporthe sclerotioides)
• Various factors activated by fluid shear stress (FSS) can induce tumor cells metastasis (2018, NA)
• Dynamic response of tumor cells to fluid shear stress (2018, NA)
• Schematic Illustrates a Model of miR372 Promotes Liver Cancer Cell Growth by Upregulating erbB-2 through Enhancing YB-1 via Targeting for PTENmiR372 accelerates malignant progression of liver cancer cells in vitro and in vivo (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Sesamum indicum)
• Venues of prenatal alcohol exposure (PAE) altering neuroinflammation (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Diaporthe sclerotioides)
• Molecular structure, posttranslational modifications, and protein–protein interactions of the Ski and SnoN proteins (2018, NA)
• Regulation of Ski and SnoN expression by different mechanisms (2018, NA)
• Regulation of the TGFB/Smad signaling pathway by Ski and SnoN (2018, NA)
• PARP1 contributes to regulation of redox-related signaling pathways (2018, NA)
• Computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention (2018, Homo sapiens)
• Pro-inflammatory AGE-RAGE signaling is activated during arousal from hibernation in ground squirrel adipose (2018, Mus musculus,Rattus norvegicus,Ictidomys tridecemlineatus,Urocitellus parryii,Spermophilus citellus,Bos taurus,Oryctolagus cuniculus,Ursus arctos,Homo sapiens,Microcebus murinus,Moloney murine leukemia virus)
• Chemotactic Signaling Cascades (2018, NA)
• Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,Murid betaherpesvirus 1,Myxoma virus,Homo sapiens,Macaca mulatta,Mus musculus)
• Chemokines and G protein mediated pathway (2018, Mus musculus,Danio rerio,Homo sapiens)
• Schematic diagram (2018, NA)
• Impaired Akt signalling leads to iron accumulation (2018, NA)
• Schematic summary showing how VPS35 might regulate LRRK2 and LRRK2 protein kinase activity and hence PD (2018, NA)
• Working model of the role of lysophosphatidic acid (LPA) at the maternal-conceptus interface in pigs (2018, NA)
• Molecular mechanism of SOCS- and IRF-regulated cytokine signaling in macrophages during ALI/ARDS (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Klebsiella pneumoniae,NA)
• Major signalling pathways involved in the control of skeletal muscle hypertrophy and mitochondrial biogenesis (2018, Homo sapiens)
• Activation of antiviral innate immunity in CHB (2018, NA)
• Interplays of interleukin-23 (IL-23), IL-6, signal transducer and activator of transcription 3 (STAT3), and retinoid-related orphan receptor Gt (RORGt) in the differentiation of pathogenic T helper 17 (Th17) cells (2018, Mus musculus,Rattus norvegicus,Prunella vulgaris,Digitalis lanata,Homo sapiens)
• Signaling pathway to Akt, eNOS, and Ca/CaM downstream of VEGFR2 (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis)
• Regulators of MST1 and MST2 (2018, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Ginkgo biloba,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,prion)
• Signaling network of MST1 and MST2 kinase (2018, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Ginkgo biloba,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,prion)
• Estrogen signaling pathway in uterine epithelium (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Stiffness-induced acute lung injury and pulmonary hypertension (2018, NA)
• SOD-dependent ROS signaling in mammalian cells (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Enterococcus faecalis,Homo sapiens)
• Mitogen-activated protein kinase signalling pathway (2018, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Gallus gallus,Citrus limon)
• Systems and synthetic biology approaches in understanding biological oscillators (2018, Xenopus laevis,Homo sapiens)
• “Immune Gate” of psychopathology – mechanisms of gut derived immune activation leading to psychiatric manifestations (2018, NA)
• EEDL on ox-LDL-induced foam cell formation in RAW 264.7 cells (2018, NA)
• Network analysis of differentially expressed genes in glioma cells exposed to exosomes (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Raphanus sativus)
• MS and network analysis of hypoxic exosomal proteome (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Raphanus sativus)
• The interaction effects of enriched KEGG pathway terms and putative target proteins identified in the present study (2018, Ginkgo biloba,Homo sapiens)
• Illustration of the Compound-Group-Target-Pathway (CGTP) network (2018, Ginkgo biloba,Homo sapiens)
• PMA signal transduction pathway leading to NGF upregulation (2018, NA)
• Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Fibroblast growth factor-23 (FGF23) pathways (2018, NA)
• Cooperation of unphosphorylated and phosphorylated ISGF3 and GAF components and IRF1 in the regulation of basal and IFN-induced transcription (2018, NA)
• IFN-dependent and -independent ISG transcription mediated by complexes comprised unphosphorylated STATs (2018, NA)
• Acquired Resistance to Drugs Targeting Tyrosine Kinases (2018, NA)
• STATus of STAT3 in Psoriatic Arthritis (2018, NA)
• NFKB and Wnt signaling pathways (2018, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• The pathway activated by drug-induced perturbation of rRNA synthesis (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathway functional enrichment of differentially expressed genes (DEGs) (a) and pathway of Proximal tubule bicarbonate reclamation (ko04964)(b) (2018, NA)
• PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway (2018, Homo sapiens,Mus musculus)
• Graphical representation of the current working hypothesis regarding anticancer mechanisms induced by paclitaxel targeting multiple signaling pathways in CHMm cells (2018, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Armoracia rusticana,Taxus brevifolia,Homo sapiens,Mus musculus)
• VEGF signaling pathways and their role in the pathogenesis of MPE (2018, NA)
• Antitumor effects of corilagin (2018, herbal medicine,Phyllanthus emblica,Terminalia chebula,Phyllanthus niruri,Phyllanthus urinaria,Acer nikoense,Libidibia coriaria,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Hepatitis B virus)
• Wnt/Beta-catenin signaling pathway (2018, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Schizosaccharomyces pombe,Homo sapiens,Caenorhabditis elegans)
• PI3K-AKT signaling pathway (2018, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Streptococcus pneumoniae,Enterococcus faecium,Mycobacterium avium subsp. paratuberculosis,Escherichia coli K1,Glaesserella parasuis,Glaesserella parasuis SH0165,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Gallus gallus,Candida albicans,Encephalomyocarditis virus,Pieris brassicae)
• Intracellular immune ecosystem in a virus infected cell (2018, NA)
• GPCRs signaling pathway in HCC (2018, Homo sapiens,Mus musculus,Hepatitis B virus)
• Tumor necrosis factor receptor signaling in multiple sclerosis (2018, NA)
• Bornyl cis-4-hydroxycinnamate-induced apoptotic pathway (2018, Armoracia rusticana,Marchantiophyta,Piper betle,Conocephalum conicum,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Stenotrophomonas maltophilia Pi1)
• Schematic overview of Annexins at the crossroad of late endocytic pathways (2018, NA)
• P62-interacting partners to activate different signaling pathways (2018, NA)
• Mammalian target of rapamycin (mTOR) signaling pathway (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Leptin is a very important factor that links fatty acid Beta-oxidation with oocytes maturation (2018, Danio rerio,Oncorhynchus mykiss,Oryzias latipes,Dipnomorpha,Salmo trutta,Oreochromis niloticus,Ctenopharyngodon idella,Ictalurus punctatus,Dicentrarchus labrax,Tachysurus fulvidraco,Salvelinus fontinalis,Perca flavescens,Lepomis cyanellus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Candida dubliniensis,Morus alba,Homo sapiens)
• Diagram of WNT (Wingless-type) signaling pathway (2018, NA)
• Schematic illustration shows the ameliorating effect of ethyl acetate fraction from persimmon (EFDK) in TMT-induced behavioral and memory dysfunction in ICR mice via regulation of the JNK/Akt signaling and apoptotic pathways (2018, NA)
• Growth hormone releasing peptide (GHRP)-peroxisome proliferator-activated receptor-gamma (PPARG) pathway in lipid and energy metabolism (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Invasion-related molecules in oral squamous cell carcinoma (2018, NA)
• Proposed role of TgACS and acetyl-CoA in the lipid biosynthetic pathway of T (2018, NA)
• P38MAPK signaling pathway in the intestinal tissue (2018, NA)
• Molecule mechanisms of ZEA induced cell death (2018, NA)
• The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival (2018, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Human gammaherpesvirus 4,Moloney murine leukemia virus,Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis,clinical samples)
• B cell receptor signaling pathway in mantle cell lymphoma (2018, Homo sapiens,Mus musculus)
• Investigation of benzylisoquinoline alkaloid biosynthetic pathway and its transcriptional regulation in lotus (2018, NA)
• Tumor suppressor molecules signaling (2018, NA)
• General schematic of terminal translocation and differentiation in the CP during development (2018, NA)
• General schematic diagram of molecular events that regulate proliferation, differentiation and the initiation of migration in the SVZ (2018, NA)
• Hippo-Yap signaling in ocular development and disease (2018, NA)
• Proposed model describing the regulatory pathway between Smad7 and hepcidin expression in hepatocytes (2018, NA)
• Schematic diagram illustrating how ɑ‐LA, via regulation of Grb2 expression, modulates different signalling pathways that participate in proliferation‐related stress responses (2018, Homo sapiens,vectors,Cistanche deserticola)
• Schematic model (2018, NA)
• Role of MICAL1 in breast cancer cell proliferation (2018, Homo sapiens,Bos taurus,Drosophila melanogaster)
• LIF and the PI3K/Akt signaling pathway (2018, Homo sapiens,Callithrix jacchus,marmosets,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana)
• GFRA1: A Novel Molecular Target for the Prevention of Osteosarcoma Chemoresistance (2018, NA)
• Aerobic glycolysis stimulation by activated canonical WNT/Beta-catenin pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• EP3 mediated signaling (adapted with kind permission from O’callaghan, G.; Houston, A.; 2015; reference ) (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Shared pathway of EP2/EP4 mediated Signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signalling pathways regulating pluripotency of stem cells regulated by detected differentially expressed miRNAs depend on muscle mass (2018, NA)
• Hippo signalling pathway identified as the most regulated by detected differentially expressed miRNAs depends on muscle mass (2018, NA)
• VEGF-STAT3 signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• VEGFR2 signal transduction and trafficking pathways mediated by VEGF-A (2018, Homo sapiens,Mus musculus,Bos taurus)
• Survivin regulation (2018, Human gammaherpesvirus 4,Adeno-associated virus,Vaccinia virus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of survivin in caspase-mediated apoptosis (2018, Human gammaherpesvirus 4,Adeno-associated virus,Vaccinia virus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Canonical B2-adrenergic receptor (B2-AR) signaling response, the anti-inflammatory cytokine profile mediated by protein kinase A (PKA), and the major anti-inflammatory cellular mediators of the resulting anti-inflammatory immune response (2018, NA)
• Beta2-adrenergic receptor signal transduction (2018, NA)
• Hypothesized hyperinsulinemia-induced cancerogenetic mechanisms (2018, NA)
• Particulate GC-A signaling pathway and renal actions overview (2018, Bos taurus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Erythroxylum coca)
• miR-302s target genes are involved in the loss of epithelial phenotype (2018, Homo sapiens,Mus musculus)
• Scheme of possible signaling pathways involved in regulating the functional state of Cx43 HCs, Panx1 Chs, P2X7Rs and Cx GJs in mesangial cells stimulated with AngII (2018, NA)
• The NF2/merlin signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• BCAAs balance and its multiple roles via PI3K-AKT-mTOR signaling pathway (2018, Gallus gallus,Ctenopharyngodon idella,Scophthalmus maximus,Cyprinus carpio jian,Mus musculus,Rattus norvegicus,Escherichia coli,Edwardsiella tarda,Homo sapiens,Sus scrofa,gut metagenome,Cucumis sativus,Apostichopus japonicus)
• IL-37 processing and release (2018, Hepatitis B virus,Human gammaherpesvirus 4,unidentified influenza virus,Mycobacterium leprae,Bacillus sp. BY,Homo sapiens,Mus musculus)
• Effect of the monoclonal antibody TRC105 in combination with Sunitinib on renal tumor derived endothelial cells (2018, NA)
• Neurofibromin level directs RAS pathway signaling and mediates sensitivity to targeted agents in malignant peripheral nerve sheath tumors (2018, Arabidopsis thaliana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Action of bioactive peptides to reduce glucose uptake in colorectal cancer cells (2018, Armoracia rusticana,Zea mays,Diaporthe sclerotioides,Malus domestica,Phaseolus vulgaris,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Bacillus subtilis,Bacillus subtilis At2,Homo sapiens)
• Up-regulation of the JAK-STAT and mTOR pathways: Ingenuity pathway maps for a JAK-STAT signaling (transducing extracellular signals to transcriptional responses) and b mTOR signaling (a master regulator for many fundamental cellular repair processes) (2018, NA)
• Possible scenarios for PanDrugs therapeutic candidates (2018, NA)
• Oncojanus effect of CI encoding genes on tumorigenesis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• SIAH-dependent proteolysis and K-RAS signal transduction (2018, Homo sapiens,Pan troglodytes,Papio anubis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Bikinia letestui,Sus scrofa,NA)
• SIAH and the RAS signaling pathway (2018, Homo sapiens,Pan troglodytes,Papio anubis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Bikinia letestui,Sus scrofa,NA)
• Pathways that influence YAP and TAZ in lung cancer (2018, NA)
• Main proteins and pathways that influence YAP and TAZ in lung development and tumorigenesis (2018, NA)
• Hippo pathway core components and their upstream regulators (2018, NA)
• p53 and potential outcomes of p38MAPK activation (2018, Homo sapiens,Mus musculus)
• Diverse regulatory mechanisms of ncRNAs on Wnt signaling pathway (2018, NA)
• Toll-like receptor signaling pathway (2018, unidentified influenza virus,Dengue virus,Zika virus,West Nile virus,H5N1 subtype,Japanese encephalitis virus,Yellow fever virus,Plum pox virus,Tembusu virus,Gallus gallus,Anas platyrhynchos,Homo sapiens,Mus musculus,NA)
• Hypothetical diagram showing target sites for the action of curcumin (diferuloylmethane) in signal transduction pathway (2018, Panax ginseng,Curcuma longa,Withania somnifera,Cinchona pubescens,Centella asiatica,Piper nigrum,Bacopa monnieri,Acorus calamus,Commiphora myrrha,Saussurea costus,Asparagus racemosus,Clitoria ternatea,Commiphora mukul,Commiphora wightii,Evolvulus alsinoides,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Main signaling pathways involved for 12 miRNAs differentially expressed after exercise from EVs purified from rat’s serum (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Danio rerio,Diaporthe sclerotioides)
• Vascular wall resident Sca-1+ progenitor cell migration in response to chemokines and lipoproteins (2018, NA)
• Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins (2018, NA)
• Regulation of stemness in the intestinal stem-cell niche (2018, NA)
• MAPK signaling to the translational machinery (2018, NA)
• MTOR and MAPK pathways affect the translatome by modulating the expression of specific subsets of mRNAs (2018, NA)
• MTOR signaling to the translational machinery (2018, NA)
• Involvement of optineurin in nuclear factor kappa B (NFKB) signaling (2018, NA)
• Lipid droplets and the immune response during protozoan infection (2018, NA)
• Schematic view of (A) estradiol and (B) progesterone signaling in neural cells through both classical and non-classical pathways (2018, Mus musculus,Rattus norvegicus,Rutilus frisii,Rutilus rutilus,Homo sapiens,Equus caballus)
• Potential immune mechanism involved in vaccination with G10E-CS (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Toxoplasma gondii)
• Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice (2018, NA)
• Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms (2018, NA)
• Putative role of Wnt signaling pathway during BoHV-1 latency-reactivation cycle (2018, Human alphaherpesvirus 1,Bovine alphaherpesvirus 1,Mus musculus,Bos taurus,Homo sapiens)
• Gq-Rho-ERK signaling (2018, Caenorhabditis elegans,Homo sapiens)
• Arteriosclerotic G3BP1/RIG-I signaling in aortic VSM, a working model (2018, Homo sapiens,Mus musculus)
• IPA identified “LXR/RXR activation” as the canonical pathway in the ESPs of TC-1 cells with the highest predicted potential/significance affected by the treatment with caerin 1.9, predicted based on label-free quantitation (2018, Ranoidea aurea,Hylidae,Dryophytes cinereus,Ranoidea chloris,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens,Corynebacterium phage gamma)
• IPA identified “Tec kinase family signalling” as the canonical pathway in the cells with the highest predicted potential/significance of being affected by the treatment of caerin 1.9, based on iTRAQ data (2018, Ranoidea aurea,Hylidae,Dryophytes cinereus,Ranoidea chloris,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens,Corynebacterium phage gamma)
• Fatty acid (FA) and ceramide synthetic pathway in autosomal recessive congenital ichthyosis converge on the corneocyte lipid envelope (CLE) (2018, Homo sapiens,Canis lupus familiaris)
• RIG-I-like receptor signaling pathway (2018, NA)
• Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans (2018, Homo sapiens)
• Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma (2018, NA)
• Mitochondrial complex III Rieske Fe-S protein processing and assembly (2018, Homo sapiens,Mus musculus)
• Role of Cic in Ras-MAPK signaling and growth control (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Disrupted signaling pathways in ABC-DLBCL (2018, Homo sapiens)
• Disrupted signaling pathways in GCB-DLBCL (2018, Homo sapiens)
• Nucleotide-associated pathways in microglia (2018, NA)
• Hierarchical regulatory network controlling different cell types of Ustilago maydis (2018, NA)
• PI3K/Akt signaling facilitates ROS detoxification and redox homeostasis (2018, NA)
• Signaling pathways that are postulated to upregulate the expression of A20 and then inhibit inflammatory mediators in macrophages induced by M protein following GAS infection (2018, Escherichia coli,Staphylococcus aureus,Streptococcus pyogenes,Streptococcus sp. group A,Streptococcus pyogenes M1 GAS,Streptococcus pyogenes serotype M1,Oryctolagus cuniculus,Capra hircus,Ovis aries,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,unidentified influenza virus)
• MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes (2018, NA)
• MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes (2018, NA)
• Senescence-associated secretory phenotype (SASP) is regulated by an interactive network of pathways that dictate its functional outcome (2018, NA)
• Antibodies that target leukemic stem cells (LSCs) and blasts directly (2018, Homo sapiens)
• Aberrant signaling in systemic lupus erythematosus (SLE) T cells (2018, NA)
• Proposed schematic pathway showing ZnR/GPR39-mediated Zn2+signaling (2018, NA)
• Schematic illustrating the proposed pathway for reduced store-operated Ca2+ entry (SOCE) in pulmonary endothelial cells after chronic hypoxia and areas for future research (2018, NA)
• Action of testosterone (T) in inducing hepatic steatosis/steatohepatitis (2018, Rattus norvegicus,Homo sapiens)
• Nutrients as donors of epigenetic marks (2018, Homo sapiens)
• Modeling the potential cellular roles of three genes upregulated by AnAc in MCF-7 and MDA-MB-231 cells (2018, Ginkgo biloba,Ananas comosus,Homo sapiens,Mus musculus,clinical samples,Leptinotarsa decemlineata)
• Dysregulation of the MiR-449b target TGFBI alters the TGFB pathway to induce cisplatin resistance in nasopharyngeal carcinoma (2018, NA)
• Atrial fibrillation genes in calcium signaling and ECM–receptor interaction (2018, NA)
• Proposed signaling cascades recruited in the setting of remote ischemic conditioning based on available data (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Sus scrofa,Vasconcellea candicans,Tacca leontopetaloides,Homo sapiens)
• Multiple signaling pathways are upregulated in MCF7 parathyroid hormone-related protein-overexpressing cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• T cell metabolic programs that link to reactive oxygen species (ROS) production and the de novo synthesis of GSH (2018, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Dex represses expression of phagosome formation-associated genes (2018, NA)
• Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1A signaling pathway (2018, Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Melia azedarach)
• Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response (2018, Xenopus laevis,Calloplesiops altivelis,Homo sapiens,Mus musculus,Bos taurus)
• Schematic model for SIRT3-induced autophagy and its underlying mechanism in SH-SY5Y cells following rotenone treatment (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• DEGs associated with TNF signaling pathway at different time points after cerebral ischemia (2018, NA)
• ERK/MAPK signaling enriched in IPA (2018, Homo sapiens)
• Prostate cancer pathway enriched in KEGG (2018, Homo sapiens)
• Pridopidine enhances cAMP/PKA and TrkB pathway genes in the YAC128 striatum (2018, NA)
• Pridopidine promotes BDNF/TrkB signaling and restores ER calcium levels in the corticostriatal pathway (2018, NA)
• The molecular mechanisms describing ARG-induced porcine alveolar macrophages activation response (2018, NA)
• Schematic illustration showing the main cascade of molecules in cardiomyocytes subjected to ischemia/reperfusion insult and the mechanism of acacetin effects (2018, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Diaporthe sclerotioides,Saussurea involucrata,Homo sapiens)
• Extracellular matrix (ECM) in structural and functional synaptic plasticity (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Morchella esculenta)
• Schematic presentation of autophagy pathway and core autophagy-related proteins targeted by various miRNAs (2018, NA)
• Historic and updated model of IRS signaling (2018, NA)
• Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress (2018, Homo sapiens)
• Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress (2018, Homo sapiens)
• Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress (2018, Homo sapiens)
• Monoclonal antibody targeting amyloid B (AB) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer’s disease (2018, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• miRNA–gene interaction network.Notes: miRNAs are shown in pink, genes from Gmagenta are shown in magenta and genes from Ggreen are shown in green (2018, NA)
• TNFA–induced telomere shortening (2018, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Summary of ROS modulation during ECM detachment (2018, NA)
• Production, elimination, and signaling of ROS (2018, NA)
• Opposite Interplay Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas (2018, NA)
• Role of WNT/beta-catenin signaling in gliomas (2018, NA)
• Wnt signaling pathway and multiple myeloma (2018, Lareunionomyces loeiensis,Symphonia globulifera,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis,Human immunodeficiency virus)
• Wnt signaling in hematopoietic stem cells and early B cell development (2018, Lareunionomyces loeiensis,Symphonia globulifera,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis,Human immunodeficiency virus)
• Schematic depiction of the canonical and non-canonical Wnt pathways (2018, Lareunionomyces loeiensis,Symphonia globulifera,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis,Human immunodeficiency virus)
• Metabolic pathway of K (2018, Ketogulonicigenium robustum,Homo sapiens)
• Schematic diagram explaining the mechanism of CSC maintenance in cervical cancer via let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Human papillomavirus type 16,Escherichia coli DH5alpha)
• Acetic acid biosynthesis pathway in plants (2018, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Diaporthe sclerotioides,Triticum aestivum,Homo sapiens,Agrobacterium tumefaciens)
• Interaction between a tumour cell and a T cell (2018, NA)
• Cell apoptosis induced by VK2 in cancer cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Oxygen sensors, VEGF pathway regulators and stem cell master regulators regulate DNA damage response gene expression in human tissues (2018, Mus musculus,Cricetulus griseus,Homo sapiens,Vasconcellea candicans)
• Proposed functional roles of HSPGs and heparanase during LPS-mediated TLR4 activation (2018, NA)
• Gene transcription in key nutrient metabolic pathways involved in lipid synthesis between L (2018, NA)
• ADT DEGs enriched in integrin signaling pathway-associated transcripts (2018, NA)
• Sustained activation of detoxification pathways promotes liver carcinogenesis in response to chronic bile acid-mediated damage (2018, NA)
• Function of the hub genes in the cell cycle signaling pathway visualized in the Kyoto Encyclopedia of Genes and Genomes (KEGG) map obtained by the Database for Annotation, Visualization and Integrated Discovery (DAVID) (2018, NA)
• MAPK Signaling pathway showing expression pattern of DEGs in Ladakhi and Sahiwal cows (2018, NA)
• Interference of Akt with PtdIns4,5P2 and TORC2 signaling (2018, Saccharomyces cerevisiae,Homo sapiens)
• Tumor necrosis factor A (TNF) regulation in health and disease and its sleep-linked effectors and actions (2018, NA)
• Schematic depicting the PI3K-Akt-mTOR signaling involved in regulating rotavirus replication (2018, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Middle East respiratory syndrome-related coronavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Coxsackievirus B3,Sindbis virus,Coxsackievirus,Chikungunya virus,Semliki Forest virus,Merkel cell polyomavirus,Rift Valley fever virus,Human rotavirus,Shrimp white spot syndrome virus,Simian rotavirus ASA11,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Matthiola incana,Lacticaseibacillus rhamnosus GG,NA,NA)
• Involvement of SNPs in miR-3117 and miR-3689d2 in childhood acute lymphoblastic leukemia risk (2018, NA)
• Natural product based sensitization of GBM (2018, Homo sapiens)
• Brief report: RRx-001 is a c-Myc inhibitor that targets cancer stem cells (2018, NA)
• p53 and metabolism: from mechanism to therapeutics (2018, NA)
• P53 regulates critical points in cell signaling and metabolism (2018, NA)
• TBP-2 regulates autophagy and apoptosis of HLECs under oxidative stress (2018, NA)
• Bile acid regulation of bile acid synthesis (2018, gut metagenome)
• Bile acid synthesis pathways (2018, gut metagenome)
• Gene regulation of ESRRG and Wnt signaling (2018, NA)
• GAS6/TAM signaling pathway (2018, NA)
• Proposed pathogenesis model of Kyasanur Forest Disease (2018, Ixodes scapularis,Ixodes ricinus,Amblyomma americanum,Rhipicephalus sanguineus,Babesia microti,Ixodes persulcatus,Ctenocephalides felis,Amblyomma maculatum,Dermacentor andersoni,Dermacentor reticulatus,Ixodes pacificus,Amblyomma hebraeum,Ornithodoros savignyi,Amblyomma variegatum,Ixodes cookei,Dermacentor nuttalli,Hyalomma asiaticum,Hyalomma marginatum,Dermacentor marginatus,Haemaphysalis spinigera,Haemaphysalis wellingtoni,Ixodes marxi,Hyalomma dromedarii,Ixodes trianguliceps,Hydrotaea spinigera,Helice formosensis,Ixodes dentatus,Ixodes ovatus,Dermacentor occidentalis,Ixodes holocyclus,Borreliella burgdorferi,Francisella tularensis,Coxiella burnetii,Rickettsia slovaca,Ehrlichia chaffeensis,Rickettsia conorii,Ehrlichia muris,Francisella tularensis subsp. tularensis,Ehrlichia canis,Rickettsia parkeri,Borreliella afzelii,Borreliella garinii,Ehrlichia ewingii,Rickettsia africae,Rickettsia australis,Desulfosarcina variabilis,Borrelia lonestari,Rickettsia rickettsii str. R,Rickettsia helvetica,Rickettsia japonica,Rickettsia sibirica,Rickettsia sibirica subsp. mongolitimonae,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Ovis aries,Felis catus,Ebola virus,Panthera tigris,Camelus bactrianus,Rift Valley fever virus,Cervus elaphus,Tick-borne encephalitis virus,Odocoileus virginianus,Tick-borne flavivirus,Langat virus,Heartland virus,Procyon lotor,Alces americanus,Powassan virus,Alkhumra hemorrhagic fever virus,Lynx rufus,Thogotovirus dhoriense,Omsk hemorrhagic fever virus,Louping ill virus,Kyasanur Forest disease virus,Russian Spring-Summer encephalitis virus,Suncus murinus,Bourbon virus,Colorado tick fever virus,Alces alces,Mus musculus,Rattus norvegicus,Rhabdomys pumilio,Hystrix cristata,Brachytarsomys albicauda,Hystrix indica,Niviventer niviventer,Homo sapiens,Chlorocebus aethiops,Macaca radiata,Semnopithecus entellus,Anacardium occidentale,Metarhizium anisopliae,Hookeriopsis cuspidata,Gallus gallus,NA)
• PI3K/AKT/mTOR/S6K pathway plays a major role in the control of immune cell homeostasis (2018, NA)
• Selective and non-selective autophagy in CD4 T cells upon T cell receptor (TCR) activation (2018, NA)
• Cancer-relevant signaling pathways (2018, NA)
• Connectivity of differentially expressed genes in the important cancer signaling pathways in the exposed children are shown according to gene expression levels (with ≥ 1.5-fold change, t test, p < 0.05) (2018, NA)
• Breast cancer related pathways (2018, NA)
• Mechanisms regulating the canonical and non-canonical Wnt pathway (2018, NA)
• TLR4 signaling pathway (2018, NA)
• Kynurenine pathway is initiated by the oxidation of tryptophan via the enzymes IDO and TDO, with downstream catabolites having toxic, antioxidant and cell-protective activity (2018, Homo sapiens)
• A schematic illustrating some of the factors proposed to affect obesity and carcinogenesis (2018, Homo sapiens)
• Schematic model for IBDV internalization and establishment of the endosome-associated replication niche (2018, NA)
• Mechanism underlying how BYD exerts a cardioprotective effect (2018, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Felis catus,Panax ginseng,Ginkgo biloba,Cinnamomum verum,Mus musculus,Rattus norvegicus,Homo sapiens)
• An illustration of the PI3K mutant, ER+ breast cancer network (2018, NA)
• Wnt and Ras-MAPK pathway genes and interacting genes with AURKA, significantly deregulated (DEA) or in the most significantly deregulated gene module (Heinz) in the two cell lines, SW480 and Caco2 (2018, Homo sapiens,Gorilla gorilla,Mus musculus,Bos taurus,bacterium NOTE)
• Pathogenetic mechanism of Samter’s triad (2018, NA)
• Metabolic pathway of arachidonic acid (2018, NA)
• Metabolic processes considered in astrocytes (2018, Homo sapiens,Rattus norvegicus)
• Astrocytic Kir4.1 potassium channels as a novel therapeutic target for epilepsy and mood disorders (2018, NA)
• Protein-protein interaction analysis of HOXA13-related genes in the first four Kyoto Encyclopedia of Genes and Genomes pathways (2018, Homo sapiens,Xenopus laevis,Human papillomavirus type 16,clinical samples)
• Mitochondrial oxidants induces selective insulin resistance (2018, Canis lupus familiaris,Capra hircus,Diaporthe sclerotioides,Vasconcellea candicans,Homo sapiens,Mus musculus)
• Regulating network of exosomal proteins and ncRNAs in tumors (2018, NA)
• Therapeutic mechanisms for high-frequency repetitive magnetic stimulation (rMS) in both undifferentiated and differentiated Neuro-2a cells (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Nerve growth factor (NGF) signaling cascade (2018, NA)
• Interaction between T follicular helper (Tfh) and B cells initiating synergetic effect of IL-21/IL-21R and CD40 ligand (CD40L)/CD40 to promote plasma cell differentiation and antibody production in EAE (2018, NA)
• Gemcitabine pharmacologic pathway (2018, Saccharomyces cerevisiae,Malus domestica,Eucalyptus intertexta,Ligustrum vulgare,Saccharomyces cerevisiae PW5,Homo sapiens,Bos taurus,Escherichia coli,Canis lupus familiaris,Macaca mulatta,Escherichia coli FCP1,Mus musculus,Anolis carolinensis)
• Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma (2018, Armoracia rusticana,Momordica charantia,Persea americana,Citrus medica,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Human papillomavirus,clinical samples)
• Proposed positive feedback loop for the regulation of PI3K/Akt and GnT‐V to promote HCC metastasis (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Phaseolus vulgaris)
• CD44-mediated downstream signaling pathways (2018, NA)
• Proposed role of TGFB1 signaling in HASM cell shortening and hyperresponsiveness (2018, NA)
• Mitochondrial DNA mediates pro-inflammatory response (2018, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Homo sapiens,Bos taurus,Human alphaherpesvirus 2)
• Cross talk between E2–estrogen receptorA (ERA) signaling pathways and circadian rhythms in breast cancer (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Non-canonical antagonism of phosphoinositide 3-kinase (PI3K) by Itpkb delays thymocyte Beta-selection and renders it Notch dependent (2018, NA)
• P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Galactose metabolism pathway in Streptococcus pneumoniae D39 (2018, NA)
• Protein regulation of the TLR2/1 signaling pathway (2018, Saccharomyces cerevisiae,Oryza sativa,Triticum aestivum,Panax ginseng,Schisandra chinensis,Penicillium sp.,Garcinia kola,Biancaea sappan,Sparganium stoloniferum,Daphne odora,Escherichia coli,Staphylococcus aureus,Human gammaherpesvirus 4,Human betaherpesvirus 5,Human gammaherpesvirus 8,Japanese encephalitis virus,Cutibacterium acnes,Mycoplasmopsis fermentans,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Canis lupus familiaris,prion)
• TLR2/1 signaling cascade and respective regulatory nodes (2018, Saccharomyces cerevisiae,Oryza sativa,Triticum aestivum,Panax ginseng,Schisandra chinensis,Penicillium sp.,Garcinia kola,Biancaea sappan,Sparganium stoloniferum,Daphne odora,Escherichia coli,Staphylococcus aureus,Human gammaherpesvirus 4,Human betaherpesvirus 5,Human gammaherpesvirus 8,Japanese encephalitis virus,Cutibacterium acnes,Mycoplasmopsis fermentans,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Canis lupus familiaris,prion)
• Contraction of smooth muscle cell: cellular pathway and the role of MYL9 and of other genes related to MMIHS (2018, Homo sapiens)
• Schematic representation of the IL-6/sIL-6RA/gp130 signaling pathways in RA FLS (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells (2018, Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus)
• Quantum dots in cytotoxicity (2018, NA)
• Magnoliae Cortex and maize modulate Porphyromonas gingivalis-induced inflammatory reactions (2018, NA)
• Anthocyanin biosynthetic pathway (2018, NA)
• Summary of the proposed mechanisms involved in the regulation of gene expression by PNX in mHypoA-GnRH/GFP and mHypoA-Kiss/GFP-3 cell models (2018, Rattus norvegicus,Homo sapiens)
• Schematic representation depicting the net effect of blueberry extract on targeting the PI3K/AKT/NFKB pathway in triple negative breast cancer (2018, Homo sapiens)
• Metabolomic fingerprint in the lungs of Mtb-infected mice (2018, Mycobacterium tuberculosis,Homo sapiens)
• Regulation of PTPIP51 in melanoma (2018, Escherichia coli,Helicobacter pylori,Porphyromonas gingivalis,Mus musculus,Rattus norvegicus,Homo sapiens,Arachis hypogaea)
• NO/sGC/cGMP signaling pathway (2018, NA)
• Proposed Model: The figure shows that mutation in GNE inhibits sialic acid synthesis that may cause hyposialylation of IGF-1R (2018, Triticum aestivum,Arachis hypogaea,Ricinus communis,Sambucus nigra,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Triportheus paranensis,Clostridium perfringens)
• Top networks of differentially expressed genes in Mvs.PT as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders (2018, NA)
• Top networks of differentially expressed genes in PTvs.N as identified by Ingenuity Pathway Analysis show strong association to cancer and connective tissue disorders (2018, NA)
• Hereditary Disorder, Organismal Injury and Abnormalities, Respiratory Disease Ingenuity Pathway Analysis (IPA) Network (2018, NA)
• Organismal Injury and Abnormalities, Cardiovascular Disease, Nutritional Disease Ingenuity Pathway Analysis (IPA) Network (2018, NA)
• Insulin signaling pathway (2018, Drosophila melanogaster,Homo sapiens)
• Dabrafenib and trametinib acting on the MAPK pathway (2018, Homo sapiens)
• Antitumor and protumor functions of GD T cells (2018, NA)
• MiRNA-gene-pathway network between sixteen intersection genes, and their corresponding pathways and differentially expressed miRNAs (2018, NA)
• The development and heterosis of internodes (2018, NA)
• Diabetic stressors lead to Schwann cell dysfunction and neurodegeneration (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Paraechinus aethiopicus)
• The components of the complex purinergic signaling pathways mediated by extracellular nucleotides (2018, Mus musculus,Homo sapiens)
• Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer (2018, Escherichia coli,Armoracia rusticana,Lareunionomyces loeiensis,Streptococcus pyogenes,Homo sapiens,Mus musculus,Bos taurus)
• Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells (2018, NA)
• Latest advances in the interplay of physical and biochemical signaling pathways leading to transcription in the tumor microenvironment (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Homo sapiens)
• Repressing the repressor: Ezh2 mediates macrophage activation (2018, NA)
• CGAS–cGAMP–STING pathway detects cytoplasmic DNA after DNA damage and activate type I IFNs and other cytokines (2018, Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Thymallus thymallus)
• Network inference reveals novel connections in pathways regulating growth and defense in the yeast salt response (2018, NA)
• Gene expression pattern related to TLR4 signaling pathway following epileptic seizure (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• Interferon regulatory factor 1 inactivation in human cancer (2018, NA)
• Mechanism of action of pharmacologic therapies (2018, NA)
• Illustration of JAK/STAT signaling pathway (2018, NA)
• PD-1/PD-Ls signaling pathway (2018, NA)
• Illustration of cross-communication network of BCR, PI3K, apoptosis, and NFKB signaling pathways (2018, NA)
• Unique genetic cassettes in a Thermoanaerobacterium contribute to simultaneous conversion of cellulose and monosugars into butanol (2018, NA)
• GRHL2 and TGFB signaling through MAP kinase pathways (2018, NA)
• TAK-733 under an Ang II-induced signaling pathway in vascular remodeling (2018, NA)
• Gastrin-CCKBR–GA12/13–RhoA–ROCK signaling in pancreatic cancer (2018, NA)
• Signaling pathways between palmitate and TNFA for CCL2 production (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• NRP-1/TNC/Integrin B3/FAK/Akt/NFKB schematic signaling pathway (2018, NA)
• Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape (2018, Saccharomyces cerevisiae,Sesamum indicum,Homo sapiens,Mus musculus)
• Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape (2018, Saccharomyces cerevisiae,Sesamum indicum,Homo sapiens,Mus musculus)
• AKT signaling pathway and acetyl-CoA metabolism to promote histone acetylation (2018, Saccharomyces cerevisiae,Sesamum indicum,Homo sapiens,Mus musculus)
• Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy (2018, NA)
• Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy (2018, NA)
• Cellular and Molecular Mechanisms Underlying Planar Cell Polarity Pathway Contributions to Cancer Malignancy (2018, NA)
• Schematic illustrating the protective mechanism of PrPC on 5-FU in drug resistant cancer cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,prion)
• Signaling and regulatory network of gp120 at apoptosis pathway (2018, NA)
• Connections of The PPN, and the direct and indirect pathway of BG-thalamocortical circuits under normal (A) and PD (B) conditions (2018, NA)
• Proteins of acute-phase signalling at stage II compared with stage I in non-responders to autologous chondrocyte implantation (ACI) (2018, Bos taurus,Canis lupus familiaris,Equus caballus,Homo sapiens,Sequoia sempervirens)
• Effects of HP on HCFs (2018, NA)
• Molecular and signaling impact of MUC5AC in various malignancies (2018, NA)
• Hypothesized molecular pathophysiology of WS (2018, NA)
• The role of inflammasomes in Parkinson's disease and Alzheimer's disease (2018, Homo sapiens,Mus musculus)
• Schematic diagram represents prevention of neuronal damage/death by herbal compounds via inhibiting microglial activation through the blockage of related signaling pathway (2018, Arachis hypogaea,Curcuma longa,Salvia miltiorrhiza,Scutellaria baicalensis,Cinnamomum verum,Sophora flavescens,Cinnamomum aromaticum,Gastrodia elata,Erigeron breviscapus,Tussilago farfara,Sophora alopecuroides,Mus musculus,Rattus norvegicus,Homo sapiens,Staphylococcus aureus)
• Insulin resistance and Alzheimer's disease (2018, NA)
• RIG-I-like receptors and toll-like receptor (TLR) 3 signaling pathway (2018, NA)
• Myeloid C-type lectins and heterologous receptors (2018, Fonsecaea pedrosoi,Fonsecaea monophora,Ixodes scapularis,Fasciola hepatica,Homo sapiens)
• VEGF signaling pathway involved in angiogenesis (2018, herbal medicine,Panax ginseng,Salvia miltiorrhiza,Prunus persica,Panax notoginseng,Cinnamomum verum,Carthamus tinctorius,Astragalus membranaceus,Angelica sinensis,Berberis aristata,Geum japonicum,Styrax officinalis,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Homo sapiens,Metaphire sieboldi)
• Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition (2018, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Diaporthe sclerotioides)
• Nucleolar response to nuclear or nucleolar DNA damage (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Danio rerio)
• RAF-MEK-ERK signaling pathway in hairy cell leukemia (2018, NA)
• Gastric cancer and Hedgehog signaling pathway: emerging new paradigms (2018, NA)
• Immune activating and suppressive effects of DNA double-strand break (DSB) signalling (2018, Homo sapiens)
• Simplified schematic diagram of inferred H (2018, NA)
• Dietary and Endocrine Regulation of Endogenous Hydrogen Sulfide Production: Implications for Longevity (2018, Homo sapiens)
• miR-135b upregulated in BLBC represses multiple genes (2018, NA)
• Fibroblast growth factor‐2 downregulation of Npnt (2018, NA)
• Non-invasive tumor genotyping using radiogenomic biomarkers, a systematic review and oncology-wide pathway analysis (2018, Homo sapiens,Rattus norvegicus,Human papillomavirus)
• Ceramide species are elevated in human breast cancer and are associated with less aggressiveness (2018, Homo sapiens,Mus musculus,clinical samples)
• In vitro study on role of σB protein in avian reovirus pathogenesis (2018, Reovirus sp.,Infectious bursal disease virus,Avian orthoreovirus,Avian reovirus strain S1133,Saccharomyces cerevisiae,Escherichia coli,Gallus gallus,Escherichia coli DH5alpha,Sequoia sempervirens,Meleagris gallopavo,Homo sapiens,Bos taurus,Venustaconcha ellipsiformis)
• Regulation mechanism of sCLU in tumor progression (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Arachidonic acid and linoleic acid metabolism signaling pathways (2018, Homo sapiens,Rattus norvegicus,Bos taurus)
• PGE2 mediates early implantation (2018, NA)
• Ovulatory cascade (2018, NA)
• Ror2‐dependent noncanonical Wnt signaling (2018, Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,Xenopus laevis,Lareunionomyces loeiensis)
• Ang/Tie pathway regulation of vascular stability (2018, Bos taurus,Oryctolagus cuniculus,Staphylococcus aureus,Plasmodium falciparum,Plasmodium vivax,Mycoplasmopsis pulmonis,Homo sapiens,Mus musculus,Candida dubliniensis,unidentified influenza virus)
• Protein and cell turnover of the skeletal muscle (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Interaction network of microRNAs identified potential mRNA targets involved in clinical features of antiphospholipid syndrome (2018, Homo sapiens,Sequoia sempervirens)
• MiRNAs targeting the IGF1R pathway in its entirety (2018, NA)
• Involvement of ZMYND8 and demethylases in the DDR and cancer (2018, NA)
• Core Photorespiration Pathway and the Putative Photorespiration Glycolaldehyde Shunt (2018, NA)
• Pathway diagram for IL-2 family signaling showing the increase in detail level as zoom level increases (2018, NA)
• Enhanced high-level diagram (EHLD) for signaling by interleukins (2018, NA)
• Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill (2018, Croton bonplandianus,Homo sapiens)
• NF2 signaling pathway plays a pro-apoptotic role in Beta-adrenergic receptor stimulated cardiac myocyte apoptosis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• BIOGF1K, a compound K-rich fraction of ginseng, plays an antiinflammatory role by targeting an activator protein-1 signaling pathway in RAW264.7 macrophage-like cells (2018, Panax ginseng)
• IKK/IKBA/NFKB signaling pathway and the apoptosis proteins are regulated by the treatment of LSF in AB(1-42)-induced BV-2 cells (2018, Armoracia rusticana,herbal medicine,Panax ginseng,Litchi chinensis,Terminalia arjuna,Gynura divaricata,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Phosphatidylinositol cycle (2018, NA)
• CDP-DAG and Kennedy pathways (2018, NA)
• One-carbon metabolism (1-CM) and pentose phosphate pathway (PPP) at the cross-road between anabolism and redox balance (2018, Homo sapiens,Mus musculus,NA)
• Illustration of p204 function in LPS/TLR4 signaling pathway (2018, Mycobacterium tuberculosis,Listeria monocytogenes,Escherichia coli K-12,Porphyromonas gingivalis,Salmonella enterica subsp. enterica serovar Minnesota,Bos taurus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Homo sapiens,Mus musculus,Armoracia rusticana,NA)
• Hypothetical model for the aggravation of autoimmune response in Pdmx-associated and spontaneous NT1.The immune response in NT1 is highly heterogenic with different pathways affected during the disease progression (2018, NA)
• Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis (2018, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Pruritic signaling pathways (2018, NA)
• Saikosaponins and implications for age-related diseases (2018, Glycine max,Bupleurum chinense,Bupleurum falcatum,Bupleurum kaoi,Mus musculus,Rattus norvegicus,Homo sapiens)
• O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance (2018, NA)
• Wnt signaling pathway regulates deiodinases (2018, NA)
• Reported characterized Ca2+signaling pathways and the proposed possible fourth pathway mediated by the SCAMK proteins (2018, Plasmodium falciparum,Trypanosoma brucei,Leishmania major,Entamoeba histolytica,Trichomonas vaginalis,Glossina morsitans,Amoebozoa,Trypanosoma brucei gambiense,Alveolata,Trypanoplasma borreli,Perkinsela sp.,Perkinsela sp. CCAP 15604,Neobodo designis,Arabidopsis thaliana,Oryza sativa,Embryophyta,Triticum aestivum,Malus domestica,Vitis vinifera,Eucalyptus intertexta,Stramenopiles,Opisthokonta,Homo sapiens,Cricetulus griseus,Vertebrata)
• Integrins that are responsible for the lung metastasis of melanoma and the inhibitors (2018, NA)
• Feline A3s inhibit the replication of FIV and are counteracted by FIV Vif (2018, Bos taurus,Oryctolagus cuniculus,Felis catus,Panthera tigris,Eutheria,Panthera leo,Panthera pardus,Acinonyx jubatus,Lynx rufus,Felis silvestris,Prionailurus bengalensis euptilurus,Prionailurus bengalensis,Puma concolor,Otocolobus manul,Human immunodeficiency virus 1,Simian immunodeficiency virus,Feline leukemia virus,Equine infectious anemia virus,Feline immunodeficiency virus,Human spumaretrovirus,Bovine immunodeficiency virus,Human foamy virus,Caprine arthritis encephalitis virus,Puma lentivirus,Feline foamy virus,Bovine lentivirus group,Homo sapiens,Macaca mulatta,Pan troglodytes,Chlorocebus aethiops,Cercocebus atys,NA,NA)
• EV71 induces multiple cellular inflammatory signals and Ca2+-dependent signals (2018, NA)
• MAMP/PAMP sensing pathways in the intestine (2018, NA)
• Hippo signaling pathway (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Equus asinus x Equus caballus,Ehrlichia chaffeensis)
• Summary of discussed cancer-relevant pathways that activate YAP and TAZ (2018, NA)
• Cellular pathways affected by genes significantly mutated in ALL (2018, Homo sapiens,Mus musculus)
• Leukocyte-intrinsic Hippo pathway functions (2018, NA)
• Hippo signaling immunomodulatory functions (2018, NA)
• Hippo signaling pathway and the anti-neoplastic immune response (2018, NA)
• Hippo signaling pathway in Drosophila and mammals (2018, Homo sapiens,Drosophila melanogaster)
• Intricate relationship between CD30 and AP-1 in Classical Hodgkin Lymphoma (CHL) and Anaplastic Large Cell Lymphoma (ALCL) (2018, Human T-cell leukemia virus type I,Betapolyomavirus macacae,Avian sarcoma virus 17,Finkel-Biskis-Jinkins murine sarcoma virus,Homo sapiens,Mus musculus)
• Signaling cascades and molecules that affect Hippo pathway signaling and YAP1/TAZ activation in MM cells (2018, NA)
• NF2/merlin-Hippo signaling cascade dysregulation (2018, NA)
• Nucleotide-binding oligomerization domain 1-mediated mucosal host defense against Helicobacter pylori infection (2018, NA)
• Naringenin in cancer development (2018, NA)
• Naringenin prevents acute and chronic CCl4-induced liver damage (2018, NA)
• Genes directly effecting TAG biosynthesis in R (2018, Saccharomyces cerevisiae,Rhodotorula toruloides,Agrobacterium tumefaciens,Homo sapiens)
• Model of miR-652-mediated mechanism of EMT in PC3 cells (2018, NA)
• Tumor cell death after electrotransfer of plasmid DNA is associated with cytosolic DNA sensor upregulation (2018, NA)
• Metabolic enzymes belonging to the most divergent group (protein sequence identity) in the context of carbohydrate metabolism (2018, Drosophila melanogaster,Caenorhabditis elegans,Trypanosoma cruzi,Aedes aegypti,Anopheles gambiae,Acyrthosiphon pisum,Ixodes scapularis,Culex quinquefasciatus,Rhodnius prolixus,Glossina morsitans,Anopheles quadrimaculatus,Pediculus humanus,Lutzomyia longipalpis,Triatoma dimidiata,Anopheles albimanus,Phlebotomus papatasi,Triatoma infestans,Triatoma brasiliensis,Panstrongylus megistus,Triatoma rubida,Triatoma matogrossensis,Meccus pallidipennis,Homo sapiens,Gallus gallus,Candida dubliniensis,Triatoma virus)
• Cell proliferation and negative apoptosis regulation in the uterine leiomyoma (2018, NA)
• BCR pathway activation (2018, NA)
• Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (2018, Homo sapiens)
• Metabotropic actions of kainate receptors (KARs) in the regulation of glutamate release in the hippocampus (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proliferation-associated lncRNAs act as MYC regulators or effectors by activating or inhibiting the MYC signaling pathway (2018, NA)
• Proliferation-associated lncRNAs act on at specific functional sites of the Wnt signaling pathway (2018, NA)
• Proposed integrated model of BTN3A1 modifications induced by phosphoantigens and leading to the antigenic activation of VG9VD2 T lymphocytes (2018, Bos taurus,Sus scrofa,Mycobacterium tuberculosis,Ovis aries,Mycolicibacterium smegmatis,Mycobacterium leprae,Eutheria,Vicugna pacos,Escherichia coli KD1,Mycobacterium tuberculosis BT1,Homo sapiens,Mus musculus)
• Platelet targeted therapeutics (2018, NA)
• Apoptosis via ROS and ASK1 signaling (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Escherichia coli,Porphyromonas gingivalis,Homo sapiens,Armoracia rusticana)
• Cell-type expression patterns of carbon metabolism-related genes in V (2018, Volvox carteri,Homo sapiens)
• PPI and miRNA-gene regulatory networks (2018, NA)
• Proinflammatory challenge and anti‐inflammatory drugs on expression of genes related to tryptophan and kynurenine metabolism (2018, Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,gut metagenome,Salmonella enterica)
• NFKB/Rel and MAPK pathways activation (2018, NA)
• Mitochondria are a platform for pattern recognition receptors (PRRs) signal transduction and regulation (2018, NA)
• Dual role for glucocorticoid-induced leucine zipper in glucocorticoid function: tumor growth promotion or suppression? (2018, NA)
• Initial stages of the sensitization in contact dermatites (2018, NA)
• Proposed model for nicotine-induced synaptic plasticity in the OFC (2018, NA)
• Heme synthesis pathway (2018, NA)
• Proposed mechanotransduction mechanism (2018, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Neisseria gonorrhoeae,Proteus mirabilis,Pseudomonas aeruginosa PA14,Streptococcus salivarius,Staphylococcus epidermidis RP62A,Escherichia faecalis,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• HIF degradation pathway in normoxia and its stabilisation in hypoxia and pseudohypoxia (2018, NA)
• Pathways of deoxyribonucleotide metabolism in mammalian cells (2018, NA)
• Molecular association of Wnt, MITF, TYR, and DCT (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,vectors)
• MIF signaling pathway and its role in tumorigenesis (2018, NA)
• Signaling pathways in the glaucomatous trabecular meshwork (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Proteomic alterations in early stage cervical cancer (2018, Homo sapiens)
• Proteomic alterations in early stage cervical cancer (2018, Homo sapiens)
• Proteomic alterations in early stage cervical cancer (2018, Homo sapiens)
• Proteomic alterations in early stage cervical cancer (2018, Homo sapiens)
• 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer (2018, Homo sapiens)
• 2’-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer (2018, Homo sapiens)
• Schematic model illustrating the relationship between glucose metabolism and radiation resistance (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Melia azedarach,Homo sapiens,Dipturus trachyderma)
• Emerging roles of epithelial-mesenchymal transition in hematological malignancies (2018, NA)
• Regulation of prophenoloxidase cascade and muscle contraction pathway (2018, Euscelidius variegatus)
• Regulation of Beta-cell autophagy (2018, NA)
• Key elements in the DNA damage response (DDR) pathway (2018, Canis lupus familiaris,Sus scrofa,Ovis aries,Myotis lucifugus,Balaena mysticetus,Desmodus rotundus,Myotis velifer,Myotis myotis,Mus musculus,Rattus norvegicus,Cricetus cricetus,Heterocephalus glaber,Cryptomys hottentotus,Mesocricetus brandti,Gallus gallus,Coturnix coturnix,Calloplesiops altivelis,Turdus migratorius,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Torreya nucifera,Homo sapiens)
• Main metabolic pathways of G6P in normal (A) and defective G6PT (B) neutrophils (2018, NA)
• PRPP riboswitches and their regulatory network (2018, NA)
• Metabolic consequences of fumarate hydratase gene deletion in Plasmodium (2018, NA)
• PI3K–AKT signaling pathway (2018, Homo sapiens,Hepatitis B virus,NA)
• AdP and PI3K/AKT signaling pathway (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Helicobacter pylori,clinical samples,Chicken anemia virus)
• Primary Cilia as a Signaling Platform for Control of Energy Metabolism (2018, NA)
• Glial IL-1B-induced upregulation of neuronal Nav1.7 (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Eucalyptus intertexta)
• Our multi-omics integrative analysis of the monolignol biosynthetic pathway in P (2018, NA)
• Pro-apoptotic mechanisms of miR-217-5p regulating the ERK-MAPK pathway at different sites (2018, NA)
• Regulation of the core components of the Hippo signaling pathway.Abbreviation: ER, estrogen receptor (2018, NA)
• Exogenous pentraxin-3 inhibits the reactive oxygen species-mitochondrial and apoptosis pathway in acute kidney injury (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• The ERK MAPK signaling pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus,Escherichia phage T7,Taeniopygia guttata)
• VEGF and PI3K/Akt/PTEN signaling pathways (2018, NA)
• FAK/paxillin/AKT signaling pathway (2018, NA)
• Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/Beta-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis (2018, NA)
• Peroxisome proliferator-activated receptor gamma (PPARG) activation (2018, NA)
• The links between chronic inflammation, oxidative stress, DNA damages and carcinogenesis (2018, NA)
• B-cell receptor signaling pathway (2018, NA)
• Metabolic and regulatory network of G (2018, NA)
• YAP signaling is associated with unfavorable prognosis for PDAC (2018, NA)
• YAP is at the epicenter of a signaling network (2018, NA)
• Identification of genes related to consecutive trauma-induced sepsis via gene expression profiling analysis (2018, NA)
• Perturbed gene network in placenta that may be reflected by the changes of circulating miRNAs in PTL (2018, Homo sapiens,Mus musculus,Bos taurus)
• Glyoxalase 1 (Glo1) sustains the metastatic phenotype of prostate cancer cells via epithelial‐to‐mesenchymal transition (EMT) control: involvement of miR‐101, hydroimidazolone (MG‐H1), argpyrimidine (AP) and TGF‐B1/Smads signalling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Chondrosia corticata)
• Signalling interaction of the death receptor pathway and mitochondrial pathway (2018, Mus musculus,Rattus norvegicus,Human alphaherpesvirus 1,Murid betaherpesvirus 1,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans)
• Ethanol-mediated changes in PKCE activities (2018, NA)
• Cross-talk between Wnt and signaling pathways (2018, Hepatitis B virus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Wnt signaling pathway (2018, Hepatitis B virus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Overview of the TLR4 signalling pathway (2018, NA)
• Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways (2018, Bos taurus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Mus musculus,Eucalyptus intertexta)
• Genes of complexes coding for the mitochondrial oxidative phosphorylation and tricarboxylic acid cycle (TCA) (2018, Homo sapiens)
• Structure of NFKB members.Notes: The NFKB family consists of three proteins with a transactivation domain (RelA [p65], cRel, and RelB) and two proteins lacking a transactivation domain (p105/p50 and p100/p52) (2018, Hepatitis B virus,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Molluscum contagiosum virus,Bovine orthopneumovirus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Ctenopharyngodon idella,Ruta angustifolia)
• Adversarial functional module (AFM) pairs (2018, NA)
• p53 signaling in the TRIM59 network (2018, Homo sapiens,Mus musculus)
• DNA damage stress response in the TRIM59 network (2018, Homo sapiens,Mus musculus)
• Simplified sketch showing the mode of action of statins as immunosuppressive strategy (2018, NA)
• Cardiomyocytes and fructolytic pathway are strongly affected in P7 hearts (2018, NA)
• NF-Kb signaling pathway regulates cellular inflammatory, oxidative and apoptosis (2018, Polygonum cuspidatum,Zea mays,Glycine max,Triticum aestivum,herbal medicine,Vitis vinifera,Salvia rosmarinus,Reynoutria japonica,Rosa roxburghii,Mentha canadensis,Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Bacillus cereus,Streptococcus mutans,Streptococcus sobrinus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Salmo salar,NA)
• Molecular mechanisms of ZIKV underlying the neuropathogenesis (2018, NA)
• Simplified scheme of established complement activation pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist (2018, NA)
• Metabolism of a methanol-essential Escherichia coli strain (2018, NA)
• HSPs and double strand break repair (2018, NA)
• HSPs and the DNA damage response (DDR) (2018, NA)
• Hepcidin regulation in cancer tissue (2018, NA)
• Hepcidin regulation and action in non-cancerous tissue (2018, NA)
• Schematic diagram summarising the biological processes underlying the association of the 35‐gene expression signature with PTEN/AKT signalling pathways (2018, NA)
• Comparison of phospholipid (PL) synthesis and lipoprotein (LP) formation pathways between 0.16, 2.5 and 10 g salmon (2018, Salmo salar,Homo sapiens)
• Summarized scheme for the regulation of spexin on bile acid pathway (2018, Carassius auratus,Epinephelus coioides,Schizothorax prenanti,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Cyclocarya paliurus)
• Putative metabolic pathway of drought stress responses in flag leaves and developing grains of Zhongmai 175 (2018, NA)
• Downstream interactors affected by deleterious SAPs in CTNNB1 and KRAS (2018, NA)
• Pathogen responses linked to autophagy (2018, Caenorhabditis elegans,Homo sapiens)
• The gut microbiota in health and MS (2018, bacterium,Homo sapiens)
• Expression difference of metabolic genes between the GX stage and X stage in BSGX001 and XH7 (2018, NA)
• Diagram of signal pathways and molecules participating in the preservation of the pluripotency state and reprogramming (2018, Bos taurus,Paraechinus aethiopicus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Moloney murine leukemia virus,Campylobacter upsaliensis,NA)
• Proposed mechanisms by which PTH activates Wnt/Beta-catenin pathway in osteoblasts and osteocytes to modulate bone turnover (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Lareunionomyces loeiensis)
• Therapeutic approaches for Treg enrichment in vivo (2018, NA)
• Signaling pathway analysis of splenic NK cells after brain ischemia (2018, NA)
• IL-10-mediated modulation of myeloid cells (2018, NA)
• Activation of TNFR1 may promote multiple alternative signaling pathways, including the activation of NFKB, RIPK1-independent apoptosis (RIA), RDA, and necroptosis (2018, Canis lupus familiaris,Felis catus,Mustela putorius furo,Metatheria,Sarcophilus harrisii,Homo sapiens,Mus musculus)
• Schematic diagram of RIPK1 domains, interacting proteins, post-translational modifications, and the catalytic enzymes that read or write these modifications (2018, Canis lupus familiaris,Felis catus,Mustela putorius furo,Metatheria,Sarcophilus harrisii,Homo sapiens,Mus musculus)
• Arachidonic acid (AA) pathway of inflammation mediators (2018, NA)
• Schematic drawing of FFAR1-stimulated signaling cascade of ERK and Akt in HASM cells (2018, NA)
• Canonical and non-canonical NFKB signaling pathways (2018, NA)
• Perinatal asphyxia and estradiol treatment in the IGF-1R signaling pathway (2018, NA)
• TREM2 mediated innate immune regulation in Alzheimer’s disease (2018, Parechinus angulosus,Polyommatus dorylas,Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG)
• Waking up muscle stem cells: PI3K signalling is ringing (2018, NA)
• Putative metabolic pathway of diphenylamine by P (2018, NA)
• Shikonin suppresses proliferation and induces apoptosis in endometrioid endometrial cancer cells via modulating miR-106b/PTEN/AKT/mTOR signaling pathway (2018, Armoracia rusticana,herbal medicine,Angelica keiskei,Heimia myrtifolia,Hepatitis B virus,Human gammaherpesvirus 8,Homo sapiens,Mus musculus)
• Proposed model for EGFR-dependent kinase cascade and feedback loop during E-cadherin force transduction (2018, NA)
• Antigen receptor signaling in naïve and anergic B cells (2018, NA)
• Events surrounding pore formation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• The proposed PTN pro-migratory signaling pathway that leads to CDK5 activation in human endothelial cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• Biomarkers of resistance to immunotherapy (2018, NA)
• EGF receptor (EGFR) effects on ABC transporters (2018, NA)
• Central C metabolic network of Brucella (adapted from ) (2018, NA)
• Pathway alterations induced by MAP17 overexpression (2018, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Helicobacter pylori)
• Illustration of MAPK pathway and the role of cisplatin in promoting apoptosis or cell survival (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Cerobasis alpha)
• Location of si:ch211-167b20.8, socs9, eif4e1c and CALML6 in the insulin signaling pathway (2018, Gallus gallus,Danio rerio,Oncorhynchus mykiss,teleost fish,Dipnomorpha,Xenopus tropicalis,Oreochromis niloticus,Vertebrata,Saccharomyces cerevisiae,Arabidopsis thaliana,Olea europaea,Schizosaccharomyces pombe,Neurospora crassa,Kluyveromyces lactis,Eremothecium gossypii,Homo sapiens,Macaca mulatta,Pan troglodytes,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Methanobacterium oryzae)
• Ehrlich pathway and diagram of new expression module for 2-PE synthesis under different promoter strengths (2018, NA)
• JIP1-mediated JNK signaling regulates synaptic NMDAR expression (2018, NA)
• Schematic representation summarizing the functional effects of the three regulatory pathways controlled by IL-1B (2018, NA)
• Cross talk between CEA, TGFB signaling, and IL6-STAT3 pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Metabolic and vascular effects of insulin (2018, Homo sapiens,Mus musculus)
• Roles of intestinal epithelial cells (IEC) autophagy in the prevention of inflammatory bowel disease (IBD) (2018, Escherichia coli,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• Enzymes and binding proteins involved in vitamin A and retinoic acid metabolism (2018, Homo sapiens)
• Schematic diagram of GDF15 activating the PI3K/AKT and MAPK pathway in cervical cancer progression (2018, NA)
• Schematic diagram on the transcriptomic profiles of metabolic pathway genes involved in the enhanced MCFA production of mutant cC14TE_B3 D (2018, Dunaliella tertiolecta,Homo sapiens)
• The PI3K/Akt signaling cascade and targeted therapeutic interventions in pancreatic cancer (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Rat sarcoma virus,Plasmid pTF1,Solanum x juzepczukii)
• Therapeutic strategies to enhance immune checkpoint inhibitors by targeting tumor-associated macrophages (TAM) (2018, NA)
• Proposed model indicating some important metabolic pathways affected by acute alcohol consumption (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,gut metagenome,Citrus limon)
• Dual Catenin Loss in Murine Liver Causes Tight Junctional Deregulation and Progressive Intrahepatic Cholestasis (2018, Homo sapiens,Mus musculus,Adeno-associated virus - 8)
• Involvement of miR-126 targetome in focal adhesion signaling pathway from KEGG is shown (2018, NA)
• miR-126 is involved in neurotrophin signaling pathway pathways including IRS1, PI3K and IKB, which their partial diagram collected from KEGG pathway is demonstrated (2018, NA)
• TCR complex activation (2018, NA)
• Signaling pathway predicted to be activated by the miRNA target predictor of IPA (2018, Haemophilus influenzae,Homo sapiens)
• Schematic summary of PDAC cell–CAF interaction and GPR68 (2018, NA)
• Cycloartobiloxanthone Induces Human Lung Cancer Cell Apoptosis via Mitochondria-dependent Apoptotic Pathway (2018, Homo sapiens,Artocarpus gomezianus)
• Resveratrol inhibits the mTOR signaling pathway in the repair of SCI (2018, NA)
• TERT levels affect EBV latent/lytic status (2018, NA)
• Epithelial proteomic networks for TRIM28 high (a) and low (b) ratio cases (2018, NA)
• Two working models explaining Sgg association with colorectal cancer (CRC) (2018, NA)
• CXCR4–CXCR7 crosstalk affecting signaling pathways (2018, Homo sapiens,Mus musculus,Corynephage beta)
• Radioresistance is associated with G2/M arrest and repression of apoptosis pathway by upregulation of Bcl‐XL, Bcl‐2 and CyclinB1/CDK1 and downregulation of p53, p21, Bax, Caspase‐3 and cleaved PARP in colorectal cancer (CRC) (2018, NA)
• Crosstalk of DNA double‐strand break repair pathways in poly(ADP‐ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2‐mutated cancer (2018, Homo sapiens,Mus musculus)
• RFc constructs on human complement (2018, NA)
• Treg likely promote tissue repair and regeneration in a tissue-specific manner (2018, Mus musculus,Rattus norvegicus,Danio rerio,Dipnomorpha,Homo sapiens,Canis lupus familiaris,Aggregatibacter actinomycetemcomitans)
• Whenever there is any inflammatory stimulus to the cell, there is activation of several molecular cascades such as NFKB, Nrf2, MAPKinase, JAK/STAT, p53, PI3K/mTOR, CREB, and Wnt/Beta catenin (2018, Nicotiana tabacum,Lareunionomyces loeiensis,Viscum album,Saposhnikovia divaricata,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium avium,Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Beta-arr is a potential therapeutic target for various diseases (2018, Homo sapiens,Mus musculus)
• Schematic overview of three different modes of cell death: apoptosis, necrosis and necroptosis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus,Sugarcane Ramu stunt disease phytoplasma)
• BGN- and DCN-mediated inhibition of the TGFB pathway and restriction of HER-2/neu signaling (2018, Homo sapiens,Mus musculus)
• Dysregulated genes and their associated microRNAs in the KEGG MAPK-signaling pathway in colorectal cancer (2018, Homo sapiens,Rattus norvegicus,Human immunodeficiency virus 1)
• Programmed death-ligand 1 (PD-L1) is the ligand of programmed death 1 (PD-1) receptor (2018, NA)
• ScRNA-seq profiling on progenitor cells and hPSCs (2018, NA)
• Proposed pathway for HDL-mediated protection against OGD-induced cardiomyocyte necrosis (2018, Bos taurus,Oryctolagus cuniculus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Armoracia rusticana)
• Signature pathway expression of xylose utilization in the genetically engineered industrial yeast Saccharomyces cerevisiae (2018, Saccharomyces cerevisiae,Homo sapiens)
• LncRNAs regulate Rho/ROCK signaling in cancer metastasis (2018, Melia azedarach,Candida pruni nom. inval.,Homo sapiens,Drosophila melanogaster,Hepatitis B virus)
• MS TLR signalling pathway (2018, Human gammaherpesvirus 4,Human endogenous retrovirus W,Multiple sclerosis associated retrovirus,Homo sapiens)
• Transcriptome effects induced by CsMADS6 overexpression in transgenic tomato sepals (2018, Saccharomyces cerevisiae,Solanum lycopersicum,Citrus sinensis,Homo sapiens)
• Illustration of systemic changes resulting from EMF inoculation within a poplar cell (2018, NA)
• Oncogene and tumor suppressor gene products regulate glucose and glutamine metabolism in cancer (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Proposed molecular mechanism for maintenance of stemness by the novel ligand–receptor combination SCRG1/BST1 (2018, NA)
• Schematic diagram demonstrates the proliferation and apoptosis pathways including the upstream and downstream cascades activated by VEGFC in the GC-1 cells (2018, NA)
• NRF2- and SIRT1-signaling pathways targeted by antioxidant compounds (2018, NA)
• Schematics of the metabolic pathways and their cellular localization affected in branched-chain organic acidurias and homocystinuria disorders mentioned in this work (2018, NA)
• ASK1 signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Topotaxis: A New Mechanism of Directed Cell Migration in Topographic ECM Gradients (2018, NA)
• BRAF kinase inhibitor resistance and alternative activation of MAPK targets and pigmentation (2018, Homo sapiens,Bos taurus,Trichomonas brixi)
• Calcium in cell cycle G1/S transitioning via the MAPK pathway (2018, NA)
• 5-HT receptors are divided into 7 families (5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6 and 5- HT7) that comprise 15 receptor subtypes (2018, NA)
• Two signaling pathways (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Salvia miltiorrhiza,Bathymaster signatus)
• Many proteins of the PKCG calcium signaling pathway are targets of mutations causing ataxia (2018, Danio rerio,Xenopus laevis,Cyprinus carpio,Mus musculus,Rattus norvegicus,Homo sapiens)
• Summary of the PKCG calcium-signaling pathway (2018, Danio rerio,Xenopus laevis,Cyprinus carpio,Mus musculus,Rattus norvegicus,Homo sapiens)
• Activation of NEMO and IKB by multiple signaling pathways (2018, NA)
• EH regulates PGN-induced inflammatory response in DCs (2018, Homo sapiens,Mus musculus,Staphylococcus aureus)
• Mechanism of 15d-PGJ2-induced anti-inflammatory effect (2018, NA)
• Programmed cell death protein 1 (PD-1) mediated intracellular signaling events during T cell activation (2018, NA)
• Compound 1G with the intermediate signaling pathway (2018, Catharanthus roseus,Taxus brevifolia,Garcinia mangostana,Garcinia hanburyi,Podophyllum peltatum,Garcinia gummi-gutta,Mus musculus,Rattus norvegicus,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Sar,Tetrahymena pyriformis,Homo sapiens,Canis lupus familiaris)
• Signal transduction Pathway analysis of the possible drug target FGR, ESR1 and GCRA and their localization (2018, Catharanthus roseus,Taxus brevifolia,Garcinia mangostana,Garcinia hanburyi,Podophyllum peltatum,Garcinia gummi-gutta,Mus musculus,Rattus norvegicus,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Sar,Tetrahymena pyriformis,Homo sapiens,Canis lupus familiaris)
• Mitochondrial UPRmt and UPRam stress response pathways (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Systemic metabolic cues with Kisspeptin, orexigenic, and anorexigenic neurons (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Ovis aries,Cyprinus carpio)
• Signaling lymphocytic activation molecules Slam and cancers: friends or foes? (2018, NA)
• Therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Analysis of the PI3K-AKT-mTOR pathway in penile cancer: evaluation of a therapeutically targetable pathway (2018, NA)
• Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells (2018, NA)
• Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells (2018, NA)
• Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells (2018, NA)
• Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells (2018, NA)
• Ubiquitin-mediated regulation of the core Hippo pathway components (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Hippo pathway and cross-talk with other signaling pathways in mammals (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• The regulatory roles of different sirtuins in the reprogramming of human skin fibroblasts to generate induced pluripotent stem cells (2018, NA)
• Metabolomic differences associated with Wnt1-initiated tumors (2018, Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Molva molva,Betapolyomavirus macacae,Turdus migratorius,Homo sapiens)
• Unfolded protein response (2018, Hepatitis B virus,Influenza A virus,Dengue virus,Respiratory syncytial virus,Human betaherpesvirus 5,West Nile virus,Japanese encephalitis virus,SARS coronavirus NS-1,African swine fever virus,SARS coronavirus LC3,Homo sapiens,Mus musculus,Bos taurus,Salmonella enterica subsp. enterica serovar Typhimurium,Trichuris muris,NA,NA)
• TAAR1 signaling pathways in the nucleus accumbens (2018, Homo sapiens,Mus musculus,Rattus norvegicus,Nicotiana tabacum,Macaca mulatta,Cannabis sativa,Poromitra oscitans)
• Major pathways governing oxidative stress in PAD (2018, NA)
• Production of lipid mediators across different disease stages of dextran sodium sulfate-induced colitis in mice (2018, Mus musculus,Homo sapiens)
• Copper-signaling pathways and molecular targets in mammalian biology (2018, NA)
• Proposed metabolic pathway for butanol–ethanol (BE) production within Thermoanaerobacterium sp (2018, Thermoanaerobacterium sp.,Homo sapiens)
• MAPK signaling pathway and the JAK-ATAT signaling pathway (2018, Mus musculus,Rattus norvegicus,Bos taurus,Danio rerio,Capra hircus,Bombyx mori,Pieris brassicae,Gobiocypris rarus,Homo sapiens,Hepatitis B virus,Arachis hypogaea)
• Osteogenic differentiation through p38 MAPK signaling pathway (2018, NA)
• Nucleic acid induced innate immune pathways and their inhibition by CDK inhibitor (CDKi) (2018, NA)
• Overview of the stress-activated protein kinase (SAPK) pathway (2018, Mus musculus,Rattus norvegicus,unidentified influenza virus,H5N1 subtype,Homo sapiens,Centella asiatica)
• CB1R-modulated major signaling pathways (2018, NA)
• cGMP signaling pathway (2018, NA)
• The mTOR-dependent metabolic pathway (2018, NA)
• NAChR signaling in intestinal stem cell function (2018, NA)
• Hippo signaling pathway (2018, NA)
• Wnt and other signaling pathways regulating pluripotency of stem cells (2018, NA)
• The signaling pathways in response to DNA damage and key effectors that interact with ER signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Human papillomavirus)
• Main mammalian mitogen-activated protein (MAP) kinase signalling pathways (2018, Bos taurus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Caenorhabditis elegans,Schizosaccharomyces pombe,Enterovirus C,Paracentrotus lividus,Rat sarcoma virus,Homo sapiens,Xenopus laevis)
• The AR induction pathway in ‘T337’ basal cuttings (2018, NA)
• An overview of resveratrol-mediated targeting of multiple signaling pathways (2018, NA)
• TGF/TGFR signaling axis (2018, NA)
• Annexin A2 (ANXA2) in cancer progression (2018, NA)
• Model representing metabolic processes and the secretion system assumed from the B1-EBT genome (2018, Mycoavidus cysteinexigens,Homo sapiens)
• RUNX1 and NFKB signaling (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Polyomavirus sp.)
• KSHV regulation of the TLR signaling pathway (2018, NA)
• Involvement of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) in DNA damage response pathway (2018, NA)
• TGFB1 signaling via SMAD-dependent/independent pathways (2018, NA)
• Signaling pathway of GRP78 (2018, NA)
• MYC and HIF-1 regulate glucose metabolism (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Hypoxia on HIF-1A (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Poecilia reticulata,Eugenia axillaris)
• Induction of necrosis by L (2018, Listeria monocytogenes,Salmonella enterica subsp. enterica serovar Typhimurium,Mycobacterium avium,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• LGM2605 inhibition of asbestos-induced NLRP3 inflammasome activation by blocking asbestos-induced reactive oxygen species (ROS) generation and activating the Nrf2-ARE pathway (2018, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Linum usitatissimum,Homo sapiens,Corynebacterium glutamicum)
• Ingenuity Pathway Analysis (IPA) diagram of the cell cycle control pathway (2018, NA)
• Phospholipase D1 and neurogenesis of neural stem cells (2018, NA)
• The intrinsic apoptotic pathway in breast cancer cells lacking Cdk5 (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Vasconcellea candicans,Homo sapiens,Rattus norvegicus,NA)
• Polysaccharide and MAPK signaling (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,PX clade,herbal medicine,Homo sapiens,Mus musculus)
• Mechanisms involved in the enhanced anti-cancer effect of the combination of GCM and ABT-737 (2018, NA)
• Possible routes of lipid oversupply-induced insulin resistances associated with mitochondrial and endoplasmic reticulum (ER) stress (2018, NA)
• One-carbon metabolism and DNA methylation (2018, Oryza sativa,Glycine max,Solanum tuberosum,Triticum aestivum,Arachis hypogaea,Fragaria x ananassa,Spinacia oleracea,Musa acuminata,Linum usitatissimum,Lens culinaris,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Mediators via JNK/MAPK signal pathway and miR-155 expression (2018, Scutellaria barbata,Homo sapiens)
• Oxidative and antioxidant programmes of UPR (2018, NA)
• Celtis choseniana eethanol extract-mediated anti-inflammatory activity (2018, NA)
• Regulation of PDE3 and PDE4 by the AKAP function of PI3KG (2018, NA)
• Epac signalosome in cardiac hypertrophy and ischemia (2018, NA)
• Transforming growth factorB (TGFB) signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cell wall integrity (CWI) signaling pathway (2018, NA)
• Proximal T-cell signaling cascade (2018, NA)
• Dot1 in the DNA damage response (2018, Saccharomyces cerevisiae,Galatella linosyris,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Possible interaction between PI3K/AKT/mTOR network and PIM in ovarian cancer (2018, NA)
• Interrelationship between PIM, AKT and mTOR adapted from figure 2 of (2018, NA)
• Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mTOR pathway adapted from figure 2 of and figure 1 of (2018, NA)
• Moloney-murine leukemia virus (PIM) kinases regulate cancerous pathways (2018, NA)
• Vicious cycle of bone metastasis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• KYA1797K as a potential strategy to overcome resistance to EGFR targeting drugs in CRC (2018, NA)
• Colorectal tumorigenesis by both APC and KRAS mutations (2018, NA)
• Wnt/Beta-catenin and RAS-ERK pathway crosstalk (2018, NA)
• Aberrancies of the Wnt/Beta-catenin and RAS-ERK pathways and their cooperation in the tumorigenesis (2018, NA)
• RAS-ERK signaling pathway (2018, NA)
• Notch pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Notch pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• SignalingEpithelial growth factor receptor signal transduction (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Influenza B virus)
• Schematic diagram illustrating the mechanism of WYHZTL formula in regulating Wnt/Beta-catenin signaling pathway (2018, NA)
• Roles of ZBTB proteins in B-cell development, differentiation, and function (2018, NA)
• Involvement of proteins found in the yolk sac fluid and the uterine fluid of pregnant mares in GO terms and pathways representing embryo-maternal interaction (2018, Bos taurus,Sus scrofa,Ovis aries,Equus caballus,Homo sapiens,Mus musculus)
• NOD-like receptor signaling pathway (2018, NA)
• Antiviral innate immune pathways in dipteran insects (2018, NA)
• Heparan sulfate induces an apoptosis/necroptosis signal pathway (2018, Homo sapiens,Mus musculus,Bos taurus,Solanum tuberosum)
• ABeta-driven Wnt-PCP pathway activation (2018, NA)
• In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases (2018, NA)
• In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases (2018, NA)
• Summary of the inhibitory effect of ILQ on PI3K/Akt/mTOR pathway members.Abbreviation: ILQ, isoliquiritigenin (2018, NA)
• MicroRNAs in the nuclear factor kappa B signaling pathways (2018, NA)
• Nuclear factor kappa B and its activation mechanisms (2018, NA)
• Protein expression levels of glioma cancer cells mapped onto the GBM pathway map from the TCGA data set (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Olea europaea,NA)
• Protein expression levels of healthy cerebral cortex cells mapped onto the GBM pathway map from the TCGA data set (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Olea europaea,NA)
• Mammalian Hippo pathway (2018, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster)
• CD99wt and CD99sh in tumor cells (2018, NA)
• Wnt signalling in the adult Drosophila midgut during homeostasis, regeneration, ageing and hyperplasia (2018, Homo sapiens,Drosophila melanogaster)
• Curcumin regulates the IGF-1R signaling pathway and the expression of VEGF (2018, NA)
• Cellular events underlying UCP1-mediated thermogenesis (2018, NA)
• Immune modulatory signaling in antigen-presenting cells (APCs) induced by binding of interleukin-10 (IL-10) to the IL-10 receptor (2018, Escherichia coli,Helicobacter pylori,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Geobacillus stearothermophilus,Salmonella enterica subsp. enterica serovar Minnesota,Mycolicibacterium vaccae,Human papillomavirus,Human papillomavirus type 16,Arachis hypogaea,Alphapapillomavirus 7,Ambrosia artemisiifolia,Artemisia vulgaris,Homo sapiens,Mus musculus,Dermatophagoides pteronyssinus,Aythya ferina,NA)
• Processes of hypoxia and angiogenesis and the canonical fibroblast growth factor (FGF) signaling pathway and newly acquired insights into their relation to the development of the osteoarthritic (OA) chondrocyte hypertrophic phenotype (2018, NA)
• MAP kinase and inflammatory signaling pathways (2018, NA)
• Canonical Ihh/PTHrP and Notch signaling pathways (2018, NA)
• Wnt- and TGFB superfamily signaling pathways (2018, NA)
• Proposed signalling pathway of maternal diabetes leading to NOX2 expression and cardiac I/R injury in the adult offspring (2018, NA)
• Wnt/beta‐catenin pathway‐related lncRNAs and their interactions in cancers (2018, Homo sapiens,Lareunionomyces loeiensis)
• Wnt/B‐catenin signalling pathway (2018, Homo sapiens,Lareunionomyces loeiensis)
• Diagram showing the biased activation of CGRP receptors and AM1/2 receptors by ADM2, as well as the downstream signal pathway (2018, NA)
• Signalling pathway of Pak1 in the heart (2018, NA)
• Regulation of the Hippo pathway in smooth muscle cells (2018, NA)
• Visual description of the IL-31 and IL-33 cascades leading to the activation of the genes and the proteins involved in the development of inflammatory disorders (2018, Homo sapiens,Macaca fascicularis,Mus musculus)
• Effect of CO on cell death pathways (2018, NA)
• Effect of CO on cellular inflammation pathways (2018, NA)
• Centrally controlled, parallel sympathetic nerve and slow neurohumoral pathways that regulate both arterial and cardiac function, and participate in the pathogenesis of hypertension and heart failure (HF) (2018, Mus musculus,Homo sapiens)
• Cartoon showing hypothetical activation of CFTR by cigarette smoke extract via prostanoid and store-operated cAMP signaling pathways (2018, NA)
• Mechanism of stress-induced tumor progression and dissemination (2018, NA)
• General overview of metabolic pathways in healthy ECs (2018, NA)
• Compiled summary of signaling pathways activated by prostanoid receptor PGE2 receptor 2 (EP2) in osteocytes, neurodegenerative diseases, and colon cancer (see text for details) (2018, NA)
• Enriched pathways in cholangiocarcinoma (2018, Homo sapiens,Fasciola hepatica)
• Mechanism of insulin resistance induced by HFSD plus agents (2018, NA)
• Arachidonic Acid Metabolism Pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Eucalyptus intertexta)
• Anti-gliomagenic effects of different psychiatric and non-psychiatric drugs as demonstrated via in vitro studies (2018, NA)
• Proposed model of the temporal contributions of Wnt ligands and Beta-catenin to Alpha-galactosylceramide (Alpha-GalCer)-induced interferon gamma (IFNG) and IL-4 responses by liver natural killer T (NKT) cells (2018, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis SP1,Homo sapiens,Mus musculus,Bos taurus,Hepatitis B virus)
• Deciphering the nature of the coral–Chromera association (2018, Trypanosoma cruzi,Leishmania mexicana,Epirrhoe alternata,Alveolata,Acropora millepora,Haliotis corrugata,Acropora digitifera,Pocillopora damicornis,Chromera velia,Orbicella faveolata,Ruditapes decussatus,Montipora digitata,Orbicella annularis,Anthopleura elegantissima,Vitrella brassicaformis,Gorgonia ventalina,Chromera velia CCMP2878,Plesiastrea versipora,Acropora tenuis,Agaricia agaricites,Haliotis tuberculata,Leptastrea purpurea,Escherichia coli,Mycobacterium tuberculosis,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,PX clade,Detonula confervacea,Symbiodinium sp. clade A,Bos taurus,Xenopus laevis,Canis lupus,Naja kaouthia,Homo sapiens,Mus musculus,NA)
• Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection (2018, NA)
• Potential metabolic capabilities (2018, Escherichia coli,Escherichia coli IS1,Thermoplasma acidophilum,Mycobacterium tuberculosis SP1,Acidithiobacillus ferrooxidans,Sulfurisphaera tokodaii str. 7,Nanoarchaeum equitans,Ignicoccus hospitalis,Thermoproteus tenax,Mycobacterium tuberculosis SP2,Pyrobaculum aerophilum,Thermoplasma volcanium,Candidatus Pacearchaeota,Thermoplasmatales archaeon,Cuniculiplasma divulgatum,Candidatus Nanopusillus acidilobi,Caldisphaera lagunensis,Thermogymnomonas acidicola,metagenome,metagenomes,environmental samples,uncultured bacterium,uncultured bacterium Of10,uncultured bacterium EC5,uncultured bacterium Of14,sediment metagenome,uncultured bacterium Of39,uncultured bacterium PG2,uncultured bacterium IN-12,Saccharomyces cerevisiae,Panicum virgatum,Erythrina poeppigiana,Mus musculus,Homo sapiens)
• Functional association between mutp53 and mevalonate pathway-associated oncogenic proteins (Ras, RhoA, YAP/TAZ) (2018, NA)
• Mevalonate pathway and mutp53 (2018, NA)
• Models of RIPK1 regulation by IKKA/B and MK2 phosphorylation (2018, NA)
• BLPs-induced anti-angiogenesis and cell cycle regulation via the Akt pathway (2018, Homo sapiens,Bos taurus,Morella rubra)
• Beneficial effects of immunobiotics on the antiviral innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells (2018, Escherichia coli,Bacillus subtilis,Lactiplantibacillus plantarum,Lactococcus lactis,Lacticaseibacillus casei,Lactobacillus acidophilus,Escherichia coli O157H7,Bifidobacterium longum,Faecalibacterium prausnitzii,Enterococcus faecium,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Clostridium butyricum,Streptococcus thermophilus,Lacticaseibacillus paracasei,Bifidobacterium bifidum,Ligilactobacillus salivarius,Mycobacteroides abscessus,Bacillus subtilis subsp. natto,Bacillus infantis,Bifidobacterium pseudolongum,Lactobacillus jensenii,Escherichia coli WC1,Empedobacter brevis,Ligilactobacillus ruminis SPM0211,Bifidobacterium thermophilum,Bovine viral diarrhea virus 1,Human rotavirus,Rotavirus A,Porcine rotavirus,Bovine rotavirus,Murine rotavirus,Bovine coronavirus,Saccharomyces cerevisiae,Aspergillus niger,Saccharomyces boulardii nom. inval.,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus)
• Antiviral Innate immune response against rotavirus in bovine intestinal epithelial (BIE) cells (2018, Escherichia coli,Bacillus subtilis,Lactiplantibacillus plantarum,Lactococcus lactis,Lacticaseibacillus casei,Lactobacillus acidophilus,Escherichia coli O157H7,Bifidobacterium longum,Faecalibacterium prausnitzii,Enterococcus faecium,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Clostridium butyricum,Streptococcus thermophilus,Lacticaseibacillus paracasei,Bifidobacterium bifidum,Ligilactobacillus salivarius,Mycobacteroides abscessus,Bacillus subtilis subsp. natto,Bacillus infantis,Bifidobacterium pseudolongum,Lactobacillus jensenii,Escherichia coli WC1,Empedobacter brevis,Ligilactobacillus ruminis SPM0211,Bifidobacterium thermophilum,Bovine viral diarrhea virus 1,Human rotavirus,Rotavirus A,Porcine rotavirus,Bovine rotavirus,Murine rotavirus,Bovine coronavirus,Saccharomyces cerevisiae,Aspergillus niger,Saccharomyces boulardii nom. inval.,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus)
• Simplified model showing ethylene–dependent and low temperature–modulated ripening pathways in kiwifruit (2018, Arabidopsis thaliana,Solanum lycopersicum,Diaporthe sclerotioides,Botrytis cinerea,Pyrus communis,Musa acuminata,Actinidia deliciosa,Actinidia chinensis,Mimosa pudica,Phomopsis sp.,Botryosphaeria sp.)
• Hierarchical clustering analysis of all differentially expressed proteins (DEPs) (812 proteins at p ≤ 0.05 with ≥ 2 unique peptides) (2018, NA)
• Role of miR-146a in diabetic microvascular complications (2018, NA)
• All roads lead to Rome: vascular inflammation (2018, NA)
• Estrogen pathway in lung carcinogenesis and its implications for targeted therapy (2018, NA)
• Basic metabolic pathways in T cells (2018, Caenorhabditis elegans,Heligmosomoides polygyrus,Homo sapiens,Mus musculus)
• Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas (2018, Homo sapiens,Mus musculus,Diaporthe sclerotioides,clinical samples,Calloplesiops altivelis)
• MiR-16 affects the pro-tumorigenic properties of the fibroblasts (2018, Homo sapiens,Mus musculus,Bos taurus,Nicotiana tabacum,clinical samples)
• Crosstalk between Shh pathway and others (2018, Drosophila melanogaster,Antarctothoa delta,Nymphalis io,Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Human papillomavirus,Paraechinus aethiopicus)
• Canonical activation of Shh pathway in vertebrates (2018, Drosophila melanogaster,Antarctothoa delta,Nymphalis io,Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Human papillomavirus,Paraechinus aethiopicus)
• Biological pathways whereby PM2.5 promotes cardiovascular events (2018, NA)
• Working model of the molecular mechanism of APE2-mediated ATR–Chk1 DDR pathway from a defined SSB structure (2018, NA)
• Mechanism of retinal pericyte migration through Angiopoietin/Tie-2 signaling pathway on diabetic rats (2018, NA)
• Paradigm of host inflammation responses to Salmonella and its interaction with autophagy as well as ubiquitination (2018, NA)
• Epidermal growth factor receptor (EGFR) and EGFRvIII in glioblastoma (GBM) (2018, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Patella vulgata,NA)
• Simplified overview of the intracellular signaling mechanisms governing CCA cell motility and invasiveness (2018, NA)
• Different modes of cooperative tumorigenesis (2018, Homo sapiens,Drosophila melanogaster)
• Non-cell-autonomous overgrowth (2018, Homo sapiens,Drosophila melanogaster)
• Cooperative interactions between the tumour and surrounding cells in tumorigenesis (2018, Homo sapiens,Drosophila melanogaster)
• Cell competition mechanisms (2018, Homo sapiens,Drosophila melanogaster)
• Pathway of compound-known target-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) (2018, NA)
• Pathway o of DXP-ER-positive breast cancer network (blue circle stands for compound target; red diamond stands for pathway; green hexagon stands for herb) (2018, NA)
• Pathway of ER-positive breast cancer target PPI network (blue circle stands for breast cancer gene; red diamond stands for pathway) (2018, NA)
• Regulation of the cell cycle (2018, NA)
• Relationship between cell cycle and common up-regulated genes identified between cancers (2018, NA)
• TRIM29 regulating anti-DNA virus immune response through targeting STING (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Human alphaherpesvirus 1,Dengue virus,Vaccinia virus,Ficus racemosa,Homo sapiens,Mus musculus,Sparus aurata)
• Alzheimer’s disease pathway and enriched gene ontology with Down-regulated genes (2018, NA)
• Transforming growth factor B1 (TGFB1) signalling via the SMAD-dependent pathway (2018, Stanieria sp.,Chromobacterium sp. 71,Chromobacterium sp. 28,Chromobacterium sp. 60,Cellulophaga sp. 10,Chromobacterium sp. 78,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Glossodia major)
• Pathways enriched for genes associated with ovarian cancer (2018, NA)
• Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease (2018, NA)
• Retinoic acid-related Orphan Receptor G (RORG): connecting sterol metabolism to regulation of the immune system and autoimmune disease (2018, NA)
• Oxidative Stress and Metabolic Reprogramming in Cr(VI) Carcinogenesis (2018, Homo sapiens,Mus musculus)
• MTOR signaling pathway (2018, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Working model of endothelial specific elevated miRNA302-367 attenuating embryonic hindbrain developmental angiogenesis by targeting CDC42 and CCND1 multiple pathways (2018, NA)
• Alterations in the mammalian Hippo signaling pathway alter FLNA phosphorylation (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Gallus gallus,Triportheus paranensis,Homo sapiens,Mus musculus,Armoracia rusticana,clinical samples)
• Molecular alterations in cortisol-producing benign adrenal cortical neoplasms (2018, Homo sapiens,Bikinia letestui,Corynephage beta)
• KEGG Apoptosis pathway with highlighted dysregulated mRNAs and miRNAs (2018, Homo sapiens)
• NRF2-mediated oxidative stress response –signaling in the nucleus (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Danio rerio)
• GPCR signaling and the organization of the stem cells niche (2018, Fasciola hepatica,Opisthorchis viverrini,Homo sapiens,Mus musculus)
• Signal transduction in relation to the IR (2018, NA)
• The molecular signaling pathways underlying the effects of CC2238/AANP in endothelial cells, smooth muscle cells, and platelets (2018, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens)
• Insulin signaling pathway and insulin mimicking function of zinc ions (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Homo sapiens,NA)
• MicroRNAs regulate gene transcription (2018, NA)
• cAMP-PKA pathway (2018, NA)
• Integrins act as “double agents” during Helicobacter pylori infection in the stomach, serving to potentiate bacterial pathogenicity while also aiding in the immune response (2018, NA)
• Death ligand pathway (2018, NA)
• Humoral IL-6-mediated inflammation in triggering EC damage (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Transformation of SphK/S1P/S1PRs signaling (2018, NA)
• Sphingolipid signaling pathway (2018, NA)
• Effect of exercise on miRNAs (2018, NA)
• The cancer-fighting mechanisms of ICL (2018, Catharanthus roseus,Angelica sinensis,Taxus brevifolia,Fallopia multiflora,Camptotheca acuminata,Podophyllum peltatum,Bupleurum scorzonerifolium,Annona glabra,Mandragora officinarum,Bursera microphylla,Mus musculus,Rattus norvegicus,Homo sapiens)
• Cancer-fighting mechanisms of BP (2018, Catharanthus roseus,Angelica sinensis,Taxus brevifolia,Fallopia multiflora,Camptotheca acuminata,Podophyllum peltatum,Bupleurum scorzonerifolium,Annona glabra,Mandragora officinarum,Bursera microphylla,Mus musculus,Rattus norvegicus,Homo sapiens)
• Major pathways involved in mucus hypersecretion (2018, NA)
• WNT pathway (2018, NA)
• PACAP stimulation of PRL promoter activity via PAC1 receptor (2018, Gallus gallus,Xenopus laevis,Cyprinus carpio,Carassius auratus,Ctenopharyngodon idella,Sparus aurata,Pagrus pagrus,Oncorhynchus tshawytscha,Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens)
• Differential control of distinct stages in adult SVZ-OB neurogenesis by different cell cycle regulatory proteins (2018, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Eucalyptus intertexta,Uria aalge)
• TLR4 signaling pathway (2018, NA)
• MicroRNAs (miRNAs) related to the epigenetic control of genes involved in demyelination, epithelial–mesenchymal transition (EMT), inflammation, pain, and loss of sensation were differentially expressed in leprosy patient (LP) (2018, NA)
• TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities (2018, Mycobacterium tuberculosis)
• Viral manipulation of STAT3: Evade, exploit, and injure (2018, Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Human betaherpesvirus 5,H1N1 subtype,Human gammaherpesvirus 8,Zika virus,H5N1 subtype,Measles morbillivirus,Human alphaherpesvirus 3,Lyssavirus rabies,Rift Valley fever virus,Human metapneumovirus,Human metapneumovirus CAN97-83,Homo sapiens,Macaca mulatta,Mus musculus,NA,NA,NA)
• Most of Theileria parva proteins involved in glycolysis and tricarboxylic acid cycles were identified in this study (2018, NA)
• Proposed model of immunopathogenesis of Borreliella burgdorferi during early cutaneous infection (2018, Borreliella burgdorferi,Homo sapiens)
• CDK5RAP3 - AKT - GSK3B - Beta-catenin pathway in gastric cancer (2018, NA)
• TLR4 intracellular signaling pathways (2018, NA)
• TLR2, TLR4, and TLR5 signaling pathways (2018, Saccharomyces cerevisiae,Candida dubliniensis,Triticum aestivum,Hordeum vulgare,PX clade,Malus domestica,Panax ginseng,Citrus limon,Lentinula edodes,Helicobacter pylori,Bacteroides fragilis,Bacteroides sp.,Homo sapiens,Mus musculus,Gallus gallus,Human immunodeficiency virus 1)
• Key players and stimuli in DRP1-mediated mitochondrial fission, both in physiologic and tumor conditions (2018, NA)
• Canonical and non-canonical Wnt pathways and their effects in pluripotent stem cells (PSCs) (2018, NA)
• Relationship between epithelial-to-mesenchymal transition (EMT) and the Wnt pathway in glioblastoma-derived stem cells (GSCs) (2018, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Trichosanthes kirilowii,Homo sapiens,Bos taurus,Drosophila melanogaster,Mouse mammary tumor virus)
• The Wnt signaling pathway that determines stem cell self-renewal (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Cell cycle arrest and apoptosis induced by BOS-102 in A549 cells (2018, NA)
• NHERF1 pathways (2018, Homo sapiens)
• Fusobacterium nucleatum pathogenesis in colorectal cancer (2018, Fusobacterium nucleatum,Homo sapiens)
• Tilianin improved myocardial apoptosis (2018, Diaporthe sclerotioides,herbal medicine,Panax ginseng,Raphanus sativus,Dracocephalum moldavica,Bauhinia championii,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Meleagris gallopavo)
• Summary of Potential Eph/Ephrin Tumor Promoting Pathways (2018, Homo sapiens)
• Summary of excitotoxic pathways, mediators and potential therapeutics (2018, Homo sapiens,Mus musculus,Rattus norvegicus,marmosets,Drosophila melanogaster,Oryctolagus cuniculus,Diaporthe sclerotioides)
• Ras signaling cross-talk protein transport (2018, Homo sapiens,Uria aalge)
• PI3K-Akt signaling and Ras signaling pathways (2018, Homo sapiens,Uria aalge)
• Under the action of BMP2 and inflammatory mediators such as tumor necrosis factor, the expression of transcription factors Runx2 and osterix can be activated via the BMP/Smad pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanism of apoptosis induction by Vesicular stomatitis virus (VSV) in the infected cell (2018, Vesicular stomatitis virus,unidentified influenza virus,Human betaherpesvirus 5,Zika virus,Human T-cell leukemia virus type I,Measles morbillivirus,Sindbis virus,Reovirus sp.,Lyssavirus rabies,Foot-and-mouth disease virus,Human rhinovirus sp.,Murid gammaherpesvirus 4,rhinovirus A2,Bos taurus,Canis lupus familiaris,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Danio rerio,Coccinella septempunctata,NA,NA,NA)
• Wnt activity is necessary for heart development and becomes very low in the adult heart (2018, Mus musculus,Rattus norvegicus,Danio rerio,teleost fish,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris)
• The cell polarity and Ca2+ noncanonical Wnt signaling pathways (2018, NA)
• Ras1 and Ras2 are activated upon nutrient availability signaling, glucose in particular (2018, NA)
• VEGFR and Hippo signaling in angiogenesis/VM (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Drosophila melanogaster,Parthenolecanium pruinosum,Photinus pyralis,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Griffonia simplicifolia,Homo sapiens)
• Ang-2 up-regulating EMT and facilitating lung cancer metastasis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Short-term retinoic acid treatment sustains pluripotency and suppresses differentiation of human induced pluripotent stem cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Armoracia rusticana)
• MAPK signaling pathway and pharmacological modulators (2018, NA)
• Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy (2018, Diaporthe sclerotioides,Syzygium polyanthum,Homo sapiens,Mus musculus,NA)
• Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction (2018, Homo sapiens,Mus musculus,Capra hircus,Triticum aestivum)
• Signal transduction by TGFBs and BMPs TGFB and BMP ligands induce formation of heteromeric complex between specific Type II and Type I receptors (2018, NA)
• PD0332991-regulated gastric cancer cell signaling networks (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Signaling pathways of different amino acids in intestinal inflammation (2018, Gallus gallus,Ctenopharyngodon idella,Cyprinus carpio jian,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Aeromonas hydrophila,Pasteurella multocida,Homo sapiens,Porcine circovirus 2,Eimeria maxima)
• Possible signaling mechanisms of amino acids in intestinal inflammation in the ECs are illustrated (2018, Gallus gallus,Ctenopharyngodon idella,Cyprinus carpio jian,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Aeromonas hydrophila,Pasteurella multocida,Homo sapiens,Porcine circovirus 2,Eimeria maxima)
• Interplay between immune system and gut microbiota in homeostasis, tolerance, and inflammation (2018, NA)
• Molecular targets of natural compounds in breast cancer pathway (2018, NA)
• Main metabolic and redox circuits regulated by the inhibition of the H+-ATP synthase by inhibitory factor 1 (IF1) (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Proposed model for Marf-mediated ER stress in FRDA flies (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Matthiola incana,Beta vulgaris subsp. vulgaris,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• TANK-binding kinase 1 (TBK1) in humoral responses (2018, NA)
• Extracellular adenosine accumulates via the breakdown of ATP, both intracellularly and extracellularly (2018, NA)
• Invariant NKT (iNKT) cell activity within the tumor microenvironment (TME) (2018, NA)
• Germinal center pathway in systemic lupus erythematosus (2018, Streptococcus pneumoniae,Francisella tularensis,Borrelia hermsii,Homo sapiens,Mus musculus,unidentified influenza virus)
• Extrafollicular (EF) pathway for the generation of autoreactive plasma cells (PCs) in systemic lupus erythematosus (2018, Streptococcus pneumoniae,Francisella tularensis,Borrelia hermsii,Homo sapiens,Mus musculus,unidentified influenza virus)
• Schematic diagram for innate immune response against influenza A virus (IAV) infection (2018, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,West Nile virus,H5N1 subtype,H3N2 subtype,H7N9 subtype,Influenza A virus H3N2,H9N2 subtype,Influenza B virus,H2N2 subtype,H17N10 subtype,Influenza D virus,H18N11 subtype,Zootoca vivipara,Anolis carolinensis,Homo sapiens,Mus musculus,Sus scrofa)
• Three pathways of the unfolded protein response (UPR) (2018, NA)
• Role of Autophagy in Zika Virus Infection and Pathogenesis (2018, NA)
• Ferroptosis-associated metabolic networks (2018, NA)
• Pathways for 1-propanol production in S (2018, Saccharomyces cerevisiae,Homo sapiens)
• Different metabolic responses in acquiring FK866 resistance in CEM RES (a) and MDA RES (b) cells (2018, Homo sapiens,Mus musculus,Bos taurus)
• NO: Nitric oxide, sGC: soluble guanylate cyclase, cGMP: cyclic guanosine monophosphate, cGKI: protein kinases (2018, Homo sapiens)
• Proposed model for the role of DAPK1‐mediated Beclin‐1 phosphorylation and TTP‐mediated Bcl‐2 mRNA destabilization in autophagy leading to the suppression of inflammatory responses by gAcrp in macrophages (2018, NA)
• SUMOylation in representative cancer pathways (2018, NA)
• Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery (2018, Trypanosoma brucei,Homo sapiens)
• Mammalian target of rapamycin (mTOR) signaling pathway (2018, NA)
• AMP‐dependent protein kinase (AMPK) signalling pathway (2018, NA)
• B cell receptor (BCR) signalling pathway (2018, NA)
• Cell cycle arrest signaling (2018, NA)
• Proposed pathway for regulation of endothelial cell signaling by breast cancer cell-derived EVs and a function-blocking CD47 antibody (2018, NA)
• The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review (2018, NA)
• T cell receptor signaling pathways in eosinophilic asthma (2018, NA)
• Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling (2018, Human gammaherpesvirus 4,Measles morbillivirus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Elotuzumab for the Treatment of Relapsed or Refractory Multiple Myeloma, with Special Reference to its Modes of Action and SLAMF7 Signaling (2018, Human gammaherpesvirus 4,Measles morbillivirus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Sotetsuflavone inhibits non-small-cell lung cancer cell invasion and metastasis (2018, NA)
• GDF11 signaling in human liver cancer (2018, Homo sapiens)
• Canonical and non-canonical Wnt signaling pathways.(Left) Unstimulated Wnt pathway results in constitutive Beta-catenin degradation (2018, NA)
• Schematic representation of IRI and RISK pathways linked to NO‐mediated cytoprotection (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Astragalus membranaceus)
• Myoblast regulation mediated by miR-16-5p (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Gallus gallus,Coturnix coturnix,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Apoptosis signaling pathways (2018, NA)
• Proteins significantly altered by torcetrapib associated with insulin sensitivity or pancreatic Beta-cell function (2018, NA)
• Classic autophagy compared with related trafficking pathways (2018, NA)
• Schematic diagram depicting the GPCR signaling pathway in the regulation fluid reabsorption in the efferent ductules (2018, Mus musculus,Homo sapiens)
• TAM pathway signaling in innate immune cells (2018, NA)
• Sinalization cascade for genesis of medulloblastoma (2018, NA)
• Preferential activation of the NGF signaling pathway in shock-sensitive methamphetamine (METH) self-administering (SA) rats (2018, NA)
• Metabolic pathway of AB and GPCRs in Alzheimer's disease (2018, NA)
• Changes in the hepatic expression levels of genes for gluconeogenesis pathway following castration of bulls (2018, NA)
• Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder (2018, NA)
• Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder (2018, NA)
• TAAR1 acting on phosphorylated tyrosine hydroxylase (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Armoracia rusticana)
• Various strategies to target Myc (2018, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus)
• Bioinformatic analysis of ATP-binding cassette subfamily A member 1 (ABCA1), revealing its preventive role in carotid plaque rupture and atherosclerosis progression during the inflammatory reaction (2018, NA)
• Unfolded protein response (2018, NA)
• Mitotic arrest and slippage in inflammation and immunity (2018, Homo sapiens,Mus musculus,Caenorhabditis elegans,Calloplesiops altivelis,dsRNA viruses)
• Agrin stimulates integrin-FAK-ILK-PAK1 mechanosignalling pathway to antagonize the Hippo pathway and activate YAP/TAZ mediated gene transcription (2018, NA)
• Convergent pathways of neuroprotection generalized for growth factors secreted by mesenchymal stem cells and synthetic antioxidants (2018, NA)
• Outline of melatonin biosynthesis in the fish pineal gland (2018, Gallus gallus,Danio rerio,teleost fish,Dipnomorpha,Epinephelus coioides,Tetrapoda,Latimeria chalumnae,Periophthalmus kalolo,Boleophthalmus boddarti,Periophthalmus modestus,Boleophthalmus pectinirostris,Periophthalmus magnuspinnatus,Periophthalmodon schlosseri,Periophthalmus barbarus,Scartelaos histophorus,Homo sapiens,Mus musculus,Bos taurus)
• Interactions among Protein Kinase C Alpha (PRKCA), NOS3, and BDKRB2 gene products within the ACE inhibitor pathway may affect the antihypertensive response to enalapril (2018, NA)
• Illustration of CLDN3 signaling in cells (2018, Homo sapiens,Rattus norvegicus,Bos taurus,Nicotiana tabacum,Clostridium perfringens)
• Antitumor mechanisms of ivermectin (2018, NA)
• Summary of the main differences between NE high and low subtypes of SCLC (2018, NA)
• Targeting DDR vulnerabilities of SCLC (2018, Homo sapiens)
• Schematic diagram shows that TM suppressed the secretion of NO, TNFA, and IL-1B by reducing the bioavailability of copper and the activity of its downstream ROS/TRAF6/AKT/NFKB signaling pathway (2018, Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Canonical pathway analysis for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis (2018, NA)
• Network pharmacology for genes determining cellular responsiveness to As2O3 using Ingenuity Pathway Analysis (2018, NA)
• The RT2 Profiler Array gene expression data using Ingenuity Pathway Analysis (IPA) software (2018, NA)
• Ingenuity Pathway Analysis to predict the effect of chemical drugs on level of Jab1/COPS5 (2018, NA)
• Ingenuity Pathway Analysis for the interaction between Jab1/COPS5 and PD-L1 (2018, NA)
• Ingenuity Pathway Analysis (IPA) for Jab1/COPS5 regulation network in cancer (2018, NA)
• Drug resistance in anaplastic lymphoma kinase‐rearranged lung cancer (2018, Homo sapiens,Mus musculus,Caenorhabditis elegans,clinical samples,NA)
• Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Fragaria x ananassa,Homo sapiens,Mus musculus)
• This figure summarizes the central s-resistin downregulation effects on hypothalamic and peripheral insulin and leptin sensitivity (2018, NA)
• Osteopontin in the progression of solid organ tumour (2018, Ocimum basilicum,Andrographis paniculata,Homo sapiens,Mus musculus,Helicobacter pylori,Hepatitis B virus,Cerobasis alpha,Corynebacterium phage gamma)
• Osteopontin in the progression of solid organ tumour (2018, Ocimum basilicum,Andrographis paniculata,Homo sapiens,Mus musculus,Helicobacter pylori,Hepatitis B virus,Cerobasis alpha,Corynebacterium phage gamma)
• MicroRNAs (miRNAs) targeting insulin signaling mediators (2018, NA)
• Immunomodulation mediated by hemocyte-derived cholinergic and adrenergic neurotransmitters (2018, Crassostrea gigas,Homo sapiens)
• Apoptotic signaling through the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) pathway (2018, Mus musculus,Rattus norvegicus,Triticum aestivum,Citrus macrophylla,Homo sapiens,Danio rerio,Canis lupus familiaris)
• Myostatin regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway (2018, Homo sapiens,Bos taurus)
• Identification of prefrontal cortex protein alterations in Alzheimer’s disease (2018, NA)
• Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death (2018, NA)
• Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone (2018, NA)
• Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies (2018, Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Osphranter robustus,Polygonatum cyrtonema)
• Immunological consequences of kidney cell death (2018, Homo sapiens,Mus musculus,Arabidopsis thaliana,Caenorhabditis elegans)
• Glucocorticoid-induced apoptotic signaling pathway (2018, NA)
• Signaling pathways of neutrophil necroptosis (2018, Influenza A virus,Murid betaherpesvirus 1,Cowpox virus,Homo sapiens,Mus musculus,Sus scrofa,Staphylococcus aureus)
• Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation (2018, NA)
• Melatonin-induced signaling pathway (2018, NA)
• Summary of the mechanism of NCK1-AS1 in CC cells (2018, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• FBXL10-promoted DLBCL cell proliferation (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Signaling networks in osteoclastogenesis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Porphyromonas gingivalis)
• CX3CR1-CX3CL1 signaling pathway and migration process of immune cells via their interactions (2018, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Respiratory syncytial virus,Vaccinia virus,Candidatus Arthromitus sp. SFB-mouse,Homo sapiens,Oryctolagus cuniculus,NA)
• CXCL12 stimulates expression of connective tissue growth factor (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Arabidopsis thaliana,Armoracia rusticana,Homo sapiens)
• Platelet Alpha-granule and dense granule formation in megakaryocytes (2018, NA)
• DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/Beta-catenin pathway via GSK3B (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana,Human papillomavirus)
• Pathways regulated by selected HPG axis-related hormone and protein in male reproduction as predicted by Pathway Ontology Database and KEGG Pathway Database (2018, Zea mays,Panax ginseng,Cistanche deserticola,Echinacea purpurea,Cistanche tubulosa,Mus musculus,Rattus norvegicus,Myodes glareolus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Danio rerio)
• Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review (2018, NA)
• Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors (2018, NA)
• TGFB1 signaling in hMSC differentiation (2018, NA)
• Anti-liver cancer mechanism of TF (2018, NA)
• Key biological pathways with DNB genes in cytokine-cytokine receptor interaction and PPAR signaling pathway (2018, Influenza A virus,unidentified influenza virus,H1N1 subtype,Influenza A virus H3N2,Homo sapiens,Colletotrichum paranaense)
• Schematic overview of the autophagy pathway and target points of its modulators (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Analyses of the potential molecular mechanisms of EPB41L4A-AS2 by a bioinformatics-based method (2018, Homo sapiens,Moloney murine leukemia virus)
• HIF-1 signalling pathway is enriched in proteins containing labile disulfide bonds (2018, Mus musculus,Rattus norvegicus,Clostridium botulinum,Clostridium botulinum BP3,Homo sapiens,Lareunionomyces loeiensis,Dipturus trachyderma,Tequatrovirus T4)
• FAK/RhoA-regulated mTORC1 and AMPK pathways (2018, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Raphanus sativus,Homo sapiens,Escherichia coli)
• Divergence in the transcriptional landscape between low temperature and freeze shock in cultivated grapevine (Vitis vinifera) (2018, NA)
• Metabolic pathway of NUCKS1 in physiological and pathological process (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus,Dipturus trachyderma)
• Hypothetical model summarizing the probable mechanisms of severe inflammation in malaria (2018, Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Leishmania major,Leishmania donovani,Plasmodium vivax,Leishmania mexicana,Theileria sp.,Homo sapiens,Mus musculus,Candida dubliniensis)
• Schematic demonstration of TCR signaling (2018, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus)
• Putative metabolic pathway involved in the synthesis of rhamnolipid in genome of P (2018, Pseudomonas aeruginosa,Bacillus subtilis At2,Serratia sp. in enterobacteria,Pseudomonas frederiksbergensis,Enterobacteriaceae bacterium,Flavobacterium enshiense,Halobacillus trueperi,Pseudomonas sp. P1,Gordonia sp. BS29,Bos gaurus,Monochamus alternatus,Homo sapiens)
• RNA-editing regulated genes in LUAD are enriched in apoptosis and innate immune-related genes (2018, NA)
• Schematic model of the regulation of the ASK1/P38 signal pathway by Trx-1 (2018, NA)
• PPI network of CAD genes (2018, NA)
• Coexpression network of CAD genes and metabolic pathway genes (2018, NA)
• CD200R-induced signaling pathway (2018, Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Human gammaherpesvirus 8,Macacine gammaherpesvirus 5,Streptococcus pneumoniae,Leishmania major,Chlamydia trachomatis,Neisseria meningitidis,Leishmania amazonensis,Musca domestica,Homo sapiens,Macaca mulatta,Mus musculus)
• Inhibition mechanism of IL-12 production through interaction of TIM-3 and Gal-9 (2018, Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Human gammaherpesvirus 8,Macacine gammaherpesvirus 5,Streptococcus pneumoniae,Leishmania major,Chlamydia trachomatis,Neisseria meningitidis,Leishmania amazonensis,Musca domestica,Homo sapiens,Macaca mulatta,Mus musculus)
• The metabolic changes in the liver of fed and fasted HrasG12S/+ mice.(a and b) Changes in gene expression in the liver of HrasG12S/+ mice under fed (a) and fasted (b) conditions (2018, NA)
• Ca2+ signal transduction pathway and other miscellaneous pathways activate in response to the electrical and mechanical stimulations (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Zea mays)
• BCR‐ABL pathway (2018, NA)
• A biological pathway regulating memory, synaptic plasticity and schizophrenia risk (2018, NA)
• Gemcitabine/birinapant effects on upstream regulatory proteins (2018, NA)
• Evasion of the DNA-sensor-mediated IFN-I signal pathway by HSV-1 (2018, NA)
• Toward novel ways of MALT1 activation? (2018, NA)
• Simplified display of the Hedgehog signaling pathway (2018, Homo sapiens,Drosophila melanogaster)
• Eukaryotic initiation factor 2 (eIF2) signaling pathway (2018, Saccharomyces cerevisiae,Glycine max,Candida dubliniensis,Panax ginseng,Sequoia sempervirens,Escherichia coli,Streptococcus iniae,Streptococcus parauberis,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Paralichthys olivaceus,Nilaparvata lugens)
• Proposed model for TORC2-Ypk1 dependent activation of the sphingolipid biosynthetic pathway in acetic acid-stressed S (2018, NA)
• Host-secreated miRNAs regulate the gut microbiota that in turn affects the host via induction of specific miRNAs (2018, Escherichia coli,Lactiplantibacillus plantarum,Fusobacterium nucleatum,Limosilactobacillus reuteri,Homo sapiens,Mus musculus,gut metagenome,Opsanus beta)
• Control of norepinephrine release and VSMC tension (2018, NA)
• Insulin/IGF-1/PI3K/Akt/GSK3B/tau signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Targeting pattern-recognition receptor signaling in human intestinal inflammation (2018, NA)
• Means to enhance the immune response in the tumor microenvironment (TME) (2018, NA)
• Schema of the anti-HIV mechanism of toll-like receptor 3 (TLR3) signaling of intestinal epithelial cells (IECs) (2018, NA)
• Diagram of shep-dependent genetic network of neuronal remodeling (2018, Drosophila melanogaster,Homo sapiens)
• Pathways that regulate mTORC1 and mTORC2 signaling (2018, NA)
• Regulation of Abl signaling by Notch (2018, Drosophila melanogaster,Homo sapiens)
• Molecular adaptations to phosphorus deprivation and comparison with nitrogen deprivation responses in the diatom Phaeodactylum tricornutum (2018, Phaeodactylum tricornutum,Arabidopsis thaliana,Zea mays,PX clade,Aspergillus niger,Nitzschia alba,Thalassiosira pseudonana,Dunaliella tertiolecta,Aureococcus anophagefferens,Skeletonema costatum,Cylindrotheca fusiformis,Chaetoceros gracilis,Cylindrotheca closterium,Achnanthes brevipes,Homo sapiens,Rattus norvegicus,Bos taurus,Escherichia coli,Salmo salar,NA)
• The folate pathway in pancreatic cancer risk (2018, NA)
• Dysregulation of the IFN-Gamma-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia (2018, NA)
• Model depicting NMJ structural organization mediated by dICA69 through its interaction with the actin regulatory proteins in the Cdc42-Cip4-Wasp pathway (2018, NA)
• G-alpha signaling pathway in uveal melanoma (2018, NA)
• Result of ‘Networks’ query way (2018, Homo sapiens)
• Signaling pathways linked to Insulin/IGF signaling in PDAC (2018, Homo sapiens,Mus musculus)
• NAD+-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning (2018, NA)
• Sirtuins in Antioxidant and Redox Signaling (2018, Homo sapiens)
• Role and mechanism of Twist1 in renal, pulmonary and skin fibrosis (2018, NA)
• String pathway to show the node of PD effects (2018, NA)
• Hippo Pathway in Cancer Stem Cell Biology (2018, NA)
• Hippo Pathway in Cancer Stem Cell Biology (2018, NA)
• Glioblastoma: new therapeutic strategies to address cellular and genomic complexity (2018, Mus musculus,Rattus norvegicus,Enterovirus C,Human rhinovirus sp.,Homo sapiens,Elephas maximus)
• An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice (2018, NA)
• Molecular signaling pathway in PC3 cells (2018, NA)
• Anti-estrogens mitigate mTORC1 inhibitor-induced activation of PI3K/AKT (2018, NA)
• Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis (2018, NA)
• Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue (2018, NA)
• The main intracellular pathways and the effects of drugs used in dyslipidemia and obesity in (A) differentiation of preadipocytes into mature adipocytes (2018, NA)
• Proposed scheme for the protective effect of ZP2495 on cardiomyocyte (2018, Mus musculus,Rattus norvegicus,Candida dubliniensis,Vasconcellea candicans,Homo sapiens,Oryctolagus cuniculus)
• Rheumatoid Arthritis-related molecular signaling pathway (2018, Homo sapiens,Bos taurus)
• Pycnogenol on the browning of white adipose tissue (2018, NA)
• Overview of Hippo-Yap signaling pathway (2018, NA)
• Activation of TLRs during heart failure (2018, Mus musculus,Rattus norvegicus,Respiratory syncytial virus,Coxsackievirus,Homo sapiens)
• Cladogenesis and Genomic Streamlining in Extracellular Endosymbionts of Tropical Stink Bugs (2018, Escherichia coli,Escherichia coli K-12,Escherichia coli IS1,Pantoea agglomerans,Phengaris arion,Graphosoma lineatum,Pantoea stewartii,Halyomorpha halys,Plautia stali,Candidatus Karelsulcia muelleri,Edessa meditabunda,Candidatus Pantoea carbekii,Riptortus clavatus,Pantoea rwandensis,Candidatus Tachikawaea gelatinosa,Edessa eburatula,Epuraea rufomarginata,Type-E symbiont of Plautia stali,Urostylis westwoodii,Euaresta bella,Glycine max,Phaeosphaeria vagans)
• MiRNA biogenesis, function in cytoplasm and nucleus-cytoplasm transport (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Capra hircus)
• Macrophage polarization in type 2 diabetes (2018, NA)
• Regulation of expression and functional role of CD38 (2018, Mus musculus,Rattus norvegicus,Hepatitis B virus,Respiratory syncytial virus,Homo sapiens,Ovis aries)
• Schematic overview of anabolic and catabolic signaling in skeletal muscle (2018, Homo sapiens)
• Differentially expressed artemisinin and other terpenoid biosynthetic pathway genes of A (2018, Artemisia annua)
• Bidirectional E-cadherin/catenin–EGFR cross talk in epithelial biology (2018, Homo sapiens)
• metabolic reprogramming in endothelial cells co-cultured with CSC and non-CSC prostate cancer cell subpopulations (2018, NA)
• Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases (2018, NA)
• Epinephrine action on the Sodium/Potassium ATPase (2018, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Establishment of a new chemical pathway for the enantiospecific synthesis of steroids (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGFB/SMAD4 signaling in cancer (2018, NA)
• Depiction of classical and nonclassical pathway to NF-kB (p65-p50 or RelBp52) translocation activation (2018, NA)
• Signaling pathways involved in the progression of extramammary Paget’s disease (2018, Homo sapiens)
• EMT activation via TGFB (2018, Homo sapiens,Mus musculus,unidentified,Moloney murine leukemia virus,NA)
• Bioinformatics prediction of genes interacting with RAC1 using Ingenuity Pathway Analysis (2018, NA)
• Calcium signaling pathway, with red font indicating target genes (2018, NA)
• miRNA-gene network contains six miRNAs and their target genes, which are involved in the insulin signaling pathway (2018, NA)
• Differentially expressed miRNA gene targets in the insulin signaling pathway (2018, NA)
• Regulation amongst the Wnt/Beta-catenin, LPA and TGFB/Smad signaling pathways and YAP/TAZ of the Hippo pathway (2018, NA)
• Regulation of the TGFB/Smad signaling pathway in glaucoma (2018, NA)
• Regulation of the Wnt/Beta-catenin signaling pathway (2018, NA)
• Core components of the Hippo pathway (2018, NA)
• Inflammatory response by Arid5a/Regnase-1/UPF1 (2018, NA)
• Methyltransfer reactions in gentamicin biosynthetic pathway (2018, NA)
• Nilotinib effects on myoblasts and skeletal myogenesis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,NA)
• Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines (2018, NA)
• Common highly linked molecules and their most significantly related signaling pathways and functions in the “matrine-CRC” merged network (2018, NA)
• SYK and downstream kinases are essential to drive inflammation and blistering in experimental epidermolysis bullosa acquisita (EBA) (2018, NA)
• Chromatin structure of human and mouse telomeres (2018, Mus musculus,Rattus norvegicus,Peprilus triacanthus,Cyclothone braueri,Homo sapiens)
• Hypothetical model for the pathogenesis of glucose intolerance and insulin resistance in TRIM31−/− mice (2018, Homo sapiens,Alouatta pigra,Alouatta caraya,Mus musculus,Rattus norvegicus,gut metagenome,human metagenome,prion)
• Anti-fibrotic effect of selected polyphenols (2018, NA)
• “cross-talk” between liver and peripheral organs in the pathogenesis of NAFLD (2018, Mus musculus,Rattus norvegicus,gut metagenome,human gut metagenome,Homo sapiens)
• Dynamic regulation of macrophage autophagy in response to Leishmania (2018, NA)
• RTK-regulated signaling in breast cancer progression (2018, NA)
• Rapidly induced cell autonomous bypass signaling (2018, NA)
• Schematic view of the circadian pathway (2018, NA)
• TKIs inhibit TKs-mediated signaling pathway (2018, NA)
• Cell signaling pathways induced by Src kinases (2018, NA)
• Crosstalk between c-Met and EGFR (2018, NA)
• Alternative downstream compounds-induced EGFR-TKIs resistance (2018, NA)
• An RTK and the downstream PI3K/AKT pathway (2018, Homo sapiens,Mus musculus,Corynebacterium phage gamma)
• HGF/c-MET signaling pathway (2018, Homo sapiens,Mus musculus)
• TKI-induced regulation of glycolytic pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• The BCR-ABL1 signaling pathways targeted by non ABL-directed inhibitors (2018, NA)
• ALK signaling pathway (2018, Homo sapiens,NA)
• Regulation of PTEN, a major regulator of the PI3K/AKT signalling pathway (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Gossypium hirsutum)
• Role of Bruton’s tyrosine kinase downstream of the B cell receptor (2018, Homo sapiens)
• Targeting RAF–MEK–ERK signaling pathway (2018, NA)
• Polyphenols for the treatment of NAFLD (2018, Homo sapiens)
• Subcellular compartmentalization of the Fe-S cluster and Moco assembly processes (2018, Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Releases and signalling of IL-33 (2018, Mus musculus,Rattus norvegicus,Plasmodium berghei,Plasmodium berghei ANKA,Homo sapiens,Gallus gallus,Canis lupus familiaris,Human gammaherpesvirus 8)
• Recognition of Mycobacterium tuberculosis (Mtb) by Dectin-1 (2018, NA)
• Therapeutic mechanisms of repetitive magnetic stimulation (rMS) following ischemia/reperfusion (I/R) injury (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Src family kinase (SFK) signaling initiated by the activated growth hormone receptor (GHR) (2018, NA)
• Schematic diagram of the three pathways of the complement system, highlighting the upregulator (properdin) and downregulator (factor H) of the alternative pathway (2018, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli BL21,Neisseria meningitidis,Neisseria gonorrhoeae,Melittangium lichenicola,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Lareunionomyces loeiensis,Triticum aestivum,Homo sapiens,Mus musculus,Xenopus laevis)
• Nrf2-ARE pathway and PI3K-Wnt/Beta-catenin dysregulation (2018, NA)
• Mechanistic basis of V-ATPase dependent signaling (2018, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Olea europaea,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Working model (2018, Homo sapiens,Mus musculus)
• P53 signaling pathway targeted by hsa-mir-34a in liver cancer (2018, NA)
• FOXC1, the new player in the cancer sandbox (2018, NA)
• Deciphering microRNA targets in pancreatic cancer using miRComb R package (2018, NA)
• Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer (2018, Homo sapiens)
• Dock derived compound against laminin receptor (37 LR) exhibits anti-cancer properties in a prostate cancer cell line model (2018, NA)
• Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia (2018, NA)
• Regulation of the TOR pathway (2018, Saccharomyces cerevisiae,Homo sapiens)
• Schema of ERBB2 (2018, Homo sapiens)
• Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway (2018, Homo sapiens,Salvia miltiorrhiza)
• Regulation of group-VII ERF factor stability in Arabidopsis (2018, NA)
• Retrograde signaling during photooxidative stress in chloroplasts (2018, NA)
• Integration of multiple low-oxygen stress-signaling pathways from diverse cellular origins (2018, NA)
• BAR and ER signalling through caveolae (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Danio rerio,Simian sarcoma-associated virus)
• Interaction of oestrogen signalling and beta‐adrenergic signalling pathways (2018, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Danio rerio,Simian sarcoma-associated virus)
• Distinct mechanisms of small-molecule inhibitors and monoclonal antibodies for targeting receptor tyrosine kinases in cancer cells (2018, Homo sapiens)
• Rationale for targeting both the Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways for suppressing cancer growth (2018, Homo sapiens)
• Key signaling pathways affected by CD5 expression (2018, Homo sapiens)
• Iron starvation responses (2018, Chlamydia trachomatis,Homo sapiens)
• Outline of main altered pathways in pancreatic neuroendocrine tumours (2018, Homo sapiens,Mus musculus)
• Sialylation pathway in eukaryotes (2018, Stramenopiles,Amoebozoa,Homo sapiens)
• Pictorial representation of p53 pathway regulated by E3 ligases and DUBs (2018, NA)
• Illustration of E3 ligases and DUBs that regulate TNF induced NFKB pathway (2018, NA)
• Illustration of E3 ligases and DUBs that regulate extrinsic pathway of Apoptosis (2018, NA)
• Regulation of Intrinsic pathway by E3 ligases and DUBs (2018, NA)
• Skin pigmentation in response to UV light (2018, Homo sapiens,Sus scrofa)
• Reciprocity in ROS and autophagic signaling (2018, NA)
• The interrelationships among p-AMPK, p-mTOR, p-ULK1, autophagy and apoptosis (2018, Mus musculus,Rattus norvegicus,Panax ginseng,Portulaca oleracea,Homo sapiens,Equus asinus)
• Canonical Wnt pathway regulates gene expression by modulating Beta-catenin levels (2018, Armoracia rusticana,Lareunionomyces loeiensis,herbal medicine,Scutellaria baicalensis,Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Hydrogen sulfide, nitric oxide, and neurodegenerative disorders (2018, NA)
• Diagram illustrates the dominating signaling pathways involving Sal- induced autophagy (2018, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound (2018, NA)
• Cell migration by endocytosis of adhesion plaques (2018, Gallus gallus,Danio rerio,Xenopus laevis,Phoenicopterus roseus,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Non-canonical Wnt signaling at the primary cilium (2018, NA)
• Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway map for Toll and IMD signaling pathway (2018, NA)
• Pleiotropic effects of statins (2018, NA)
• Assessment of liver microenvironment through whole-genome RNA Seq (2018, Plasmodium berghei,Homo sapiens)
• Schematic representation demonstrating the mechanism by which silibinin inhibits NSCLC metastasis via the EGFR/LOX signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Silybum marianum)
• KEGG database illustration of the MAP kinase pathway (2018, NA)
• Role of ROS in signal transduction (2018, Homo sapiens,Mus musculus)
• Schematic overview of the effects of Saccharomyces boulardii CNCM I-745 on enzymes within the small intestine (2018, Escherichia coli,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Salmonella enterica subsp. enterica serovar Typhimurium str. DT104,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces boulardii nom. inval.,Homo sapiens,Bos taurus,Drosophila melanogaster,Gallus gallus)
• RHBDD1 promotes metastasis in colorectal cancer (2018, NA)
• Canonical hippo signaling pathway (2018, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pharmacological targeting of KLFs in vascular inflammation (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Signaling events that are induced by the LH surge and regulate the processes of ovulation and luteinization (2018, Homo sapiens,Mus musculus,Bos taurus)
• Hedgehog signaling pathway components in the ovary (2018, Homo sapiens,Mus musculus,Bos taurus)
• Insulin signaling and type 1 diabetes mellitus pathways (2018, Homo sapiens)
• Deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder, developmental disorder networks induced by ACHN cells defined by Ingenuity Pathway Analysis (2018, NA)
• Significantly deregulated networks in NL-20 cells: Cell-to-cell signaling and interaction, connective tissue disorder and developmental disorder induced by Caki-2 cells defined by Ingenuity Pathway Analysis (2018, NA)
• Top deregulated networks in NL-20 cells: Hematological system development and function, immunological disease, lymphoid tissue structure and development network induced by Caki-2 cells defined by Ingenuity Pathway Analysis (2018, NA)
• Tumorigenic proteins significantly upregulated in the IMR-32 cells mapped to the MYCN proto-oncogene, bHLH transcription factor (MYCN) pathway (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Human gammaherpesvirus 4,Human papillomavirus,Homo sapiens,Mus musculus,Sequoia sempervirens)
• Summarization of biological function by a Concept Ontology (2018, NA)
• Upstream cell signaling pathway of autophagy (2018, NA)
• NSAIDs significantly induce autophagy (2018, NA)
• IL-17 signaling pathway in NTM-infected respiratory epithelium (2018, NA)
• Functional enrichment of combined differentially expressed gene list in severe asthma across all tissues (2018, NA)
• Oncogenic cooperation of BRAF V600E and TERT promoter mutations (2018, NA)
• The gene targets of miRNA identified by NGS in the AIS patients and their role in osteoblast and osteoclast differentiation depicted from KEGG and DIANA miRPath v3 (2018, Homo sapiens,Mus musculus,Dipturus trachyderma)
• An atypical IL-6-Stat3-RFX1-IL-17A regulatory pathway in CD4+ T cells of SLE patients (2018, NA)
• Inflammatory responses and inflammation-associated diseases in organs (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Theobroma cacao,NA)
• Inflammatory responses and inflammation-associated diseases in organs (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Theobroma cacao,NA)
• Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation (2018, Candida dubliniensis,Matthiola incana,Cucumis anguria,Bos taurus,Sus scrofa,Homo sapiens,Rattus norvegicus,NA)
• Factors implicated in manifestation of disease during drug treatment (2018, Homo sapiens,Mus musculus)
• AP1 and CEBP mediated skin barrier impairment by BM (2018, Homo sapiens,Mus musculus)
• TNF mediated anti-inflammatory effect of BM (2018, Homo sapiens,Mus musculus)
• TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway (2018, NA)
• RBM20 structure and potential TTN splicing mechanism(s) regulated by RBM20 (2018, NA)
• Striated sarcomere structure and TTN-mediated signaling pathway (2018, NA)
• Systematic review and meta-analysis of bidirectional effect of arsenic on ERK signaling pathway (2018, NA)
• Gene and pathway interaction networks obtained after functional enrichment analysis using ClueGO, a Cytoscape plug-in (2018, NA)
• CAD backbone network (2018, NA)
• Kyoto Encyclopedia of Genes and Genomes pathway of hsa04622: RIG-I-like receptor signaling pathway (2018, NA)
• Intracellular signaling mechanisms that induce epithelial mesenchymal transition during CSE-induced aberrant EGFR activation in human RPE cells (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Nicotiana tabacum,Capra hircus,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• Parathyroid tumorigenesis mechanisms via the cyclins pathway (2018, NA)
• Mechanistic map of the signaling pathways involved in local translation mediated by class I mGluRs in neurons (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Xenopus laevis)
• TRAF-STOP Treatment Reduces Atherosclerosis and Preserves ImmunityBinding of CD40L to CD40 results in the recruitment of tumor necrosis factor receptor-associated factors (TRAFs), and propagation of signaling (2018, Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Mus musculus,Escherichia coli)
• Pathways for TP induced apoptosis of SCs (2018, NA)
• Effects and underlying mechanisms of lncRNAs in various fibroses (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Metaphire sieboldi)
• CK1Alpha-, 26 S proteasome-dependent turnover of FOXO tumour suppressors in RAS-mutant cancer cells (2018, NA)
• Prostaglandin E2 (PGE2) signaling through EPRs 1–4 (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Anas platyrhynchos,Petrocephalus catostoma,Homo sapiens,Respiratory syncytial virus,Corynephage beta)
• TLR4 signaling pathways (2018, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Anas platyrhynchos,Petrocephalus catostoma,Homo sapiens,Respiratory syncytial virus,Corynephage beta)
• Proposed model of the mechanism that mediates the neuroprotective action of ANP on PD cellular model (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Lareunionomyces loeiensis)
• C-type lectin receptor (CLR) signaling in fungal recognition (2018, NA)
• p38 mediates the transcription and the translation of E-selectin by modulating miR-146a and miR-31 (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Triportheus paranensis)
• Proposed model for regulation of S6 phosphorylation (P) by the cAMP/PKA pathway (2018, NA)
• Transcripts relating to the classical complement pathway are overabundant in subclinical and active TB (2018, NA)
• Egulation of actin cytoskeleton pathway and the differentially expressed genes on the bare and the TiN-coated NiTi alloys (2018, NA)
• TGFB signaling pathway and the differentially expressed genes in both the bare and the TiN-coated NiTi alloy groups (2018, NA)
• Two possible mechanisms of programmed cell death ligand 1 (PD‐L1) regulation in Epstein‐Barr virus (EBV)‐positive nasopharyngeal carcinoma (NPC) (2018, Human gammaherpesvirus 4,Human papillomavirus,Homo sapiens,Mus musculus)
• Biochemical function and regulation of indolamine-2,3-dioxygenase 1 (IDO1) (2018, NA)
• mTORC1 and mTORC2 complexes (2018, NA)
• mTOR signaling during autophagy (2018, NA)
• Schematic overview of the roles of the Notch pathway in CD8+ T cells and its application to immunotherapy (2018, NA)
• Representation of proteins and protein complexes involved in the “Autophagy – animal” KEGG pathway (2018, Saccharomyces cerevisiae,Hypericum perforatum,Arctium lappa,Saccharomyces sp.,Phyllanthus acidus,Mus musculus,Rattus norvegicus,prion,unidentified,Homo sapiens)
• Genes involved in phenylpropanoids pathway are up regulated in the epidermis (2018, NA)
• Endothelial Progenitor Cells for the Vascularization of Engineered Tissues (2018, NA)
• Exon 3 mutations of CTNNB1 drive tumorigenesis: a review (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Exon 3 mutations of CTNNB1 drive tumorigenesis: a review (2018, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Decorin and downstream signaling cascades in tumor cells (2018, NA)
• Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis (2018, Homo sapiens,Mus musculus)
• Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis (2018, Homo sapiens,Mus musculus)
• Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer (2018, NA)
• Activated endothelial cells modulate allogenic T lymphocyte activity (2018, Homo sapiens,Mus musculus)
• Tumor microenvironment (TME) (2018, Homo sapiens,Mus musculus,Candida dubliniensis,Mouse mammary tumor virus)
• Amino acid metabolism in different cell types (2018, Homo sapiens,Mus musculus,Candida dubliniensis,Mouse mammary tumor virus)
• The fatty acid (FA) synthesis in different cell types (2018, Homo sapiens,Mus musculus,Candida dubliniensis,Mouse mammary tumor virus)
• The glycolytic pathway in different cell types (2018, Homo sapiens,Mus musculus,Candida dubliniensis,Mouse mammary tumor virus)
• Schematic representations demonstrating the role LdISP2 in the modulation of host response (2018, NA)
• ROS generation metabolomics, transcriptomics, and metabotranscriptomics (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Caenorhabditis elegans,Danio rerio)
• Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Schinus terebinthifolia,Homo sapiens)
• TREM2-DAP12 signaling (2018, NA)
• Deregulated frizzled (FZD) in Wnt/Beta-catenin signaling (2018, NA)
• Mechanism of arteriogenesis (2018, Homo sapiens)
• Overview of anticancer properties of pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene; PS) (2018, NA)
• Tumor progression toward cancer metastasis (2018, NA)
• Systematic diagram to illustrate the enhanced pro inflammatory systemic response in CAE (2018, NA)
• Malignant pleural mesothelioma disease progression (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,clinical samples,Betapolyomavirus macacae,NA)
• MGF accelerates glycolysis (2018, Mus musculus,Rattus norvegicus,Candida dubliniensis,Mangifera indica,Homo sapiens,Gallus gallus,Equus caballus)
• Change in the metabolism of adenosine signaling between the states of healthy and infected (2018, NA)
• PB1-F2 virulence (2018, Influenza A virus,unidentified influenza virus,H1N1 subtype,H5N1 subtype,H3N2 subtype,H7N9 subtype,H9N2 subtype,Swine influenza virus,H2N2 subtype,H1N2 subtype,H7N7 subtype,H5N6 subtype,H3N8 subtype,H1N1 swine influenza virus,Canis lupus familiaris,Sus scrofa,Equus caballus,Mustela putorius furo,Gallus gallus,Meleagris gallopavo,Anas platyrhynchos,Homo sapiens,Mus musculus)
• Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Venustaconcha ellipsiformis)
• BMP-triggered signalling pathway and major regulators (2018, Mus musculus,Rattus norvegicus,Hepatitis B virus,Adeno-associated virus,Homo sapiens,Danio rerio,NA)
• Signaling pathways for melanin inhibition by NSC-CM (2018, Mus musculus,Rattus norvegicus,Agaricus bisporus,Lepidium apetalum,Homo sapiens,Bos taurus)
• Neuronal CaMKII-PP1 signaling (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Betapolyomavirus macacae)
• Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses (2018, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,Human orthopneumovirus,H7N9 subtype,Influenza A virus H3N2,Hepatitis C virus genotype 1,H17N10 subtype,Canis lupus familiaris,Sus scrofa,Equus caballus,Mustela putorius furo,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Cereibacter sphaeroides)
• Only the classical role of the Fanconi anemia (FA) pathway in the repair of interstrand cross-links (ICLs) is depicted, which involves highly coordinated protein–DNA and protein–protein interactions in the nucleus (2018, Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Nicotiana tabacum,Phytolacca americana,Homo sapiens,Mus musculus)
• Canonical type I and III IFN signaling (2018, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Human betaherpesvirus 5,Zika virus,West Nile virus,Enterovirus C,Murid betaherpesvirus 1,Reovirus sp.,Coxsackievirus,Yellow fever virus,Porcine epidemic diarrhea virus,Murine norovirus,Human rotavirus,Simian rotavirus A strain RRV,Murine rotavirus,Human adenovirus 40,gut metagenome,human gut metagenome,human metagenome,Homo sapiens,Mus musculus,Staphylococcus aureus,Lareunionomyces loeiensis,NA)
• Complement amplification loop (2018, Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,Streptococcus pyogenes,Neisseria meningitidis,Streptococcus sp. group A,Klebsiella aerogenes,Homo sapiens,Oryctolagus cuniculus,Canis lupus familiaris,Macaca fascicularis,Mus musculus,Lareunionomyces loeiensis,Apogonichthyoides nigripinnis)
• KEGG NFKB Signalling Network with dysregulated mRNAs highlighted and their associated miRNAs included (2018, Homo sapiens)
• T cell activation induces autocrine and intracellular complement activation that regulates T cell metabolic function and inflammasome formation (2018, Human gammaherpesvirus 4,Measles morbillivirus,Homo sapiens,Mus musculus,Danio rerio,Lareunionomyces loeiensis)
• FoxOs related signaling pathway in cancer progression and metastasis (2018, NA)
• Calcium signaling pathway (2018, Helicobacter pylori,Helicobacter pylori 8A3,Homo sapiens,gut metagenome,Capsosiphon fulvescens)
• Schematic diagram on regulation of PCSK9 on apoB via modulating the autophagy pathway affecting atherogenesis (2018, Nicotiana tabacum,herbal medicine,Homo sapiens,Mus musculus)
• Gelidium elegans extract and type 2 diabetes via MAPK and PI3K/Akt signaling (2018, Gelidium elegans,Homo sapiens)
• Crosstalk between canonical and alternative Wnt signalling and the Hippo pathway (2018, NA)
• Transcription complexes induced by physiological and aberrant Wnt pathway activation (2018, NA)
• Cancer cell signaling and regulation of alternative splicing (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular aspects of BMAA-induced neurodegeneration mechanisms (2018, Phaeodactylum tricornutum,Nitzschia alba,Thalassiosira pseudonana,Gymnodinium catenatum,Chaetoceros sp.,Chaetoceros calcitrans,Cycas micronesica,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Pinna nobilis,Haemopis sanguisuga,Homo sapiens,Pteropodidae)
• Interactions of anti-inflammatory signaling pathways and carotenoids (2018, Nicotiana tabacum,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Candida dubliniensis,Embryophyta,PX clade,Phaeodactylum tricornutum,Nitzschia alba,Chlorella vulgaris,Haematococcus lacustris,Dunaliella salina,Chlorella sorokiniana,Galdieria sulphuraria,Chlorella sp.,Nannochloropsis sp.,Porphyridium purpureum,Chromochloris zofingiensis,Auxenochlorella pyrenoidosa,Auxenochlorella protothecoides,Botryococcus braunii,Parachlorella kessleri,Pseudochlorella pringsheimii,Sargassum siliquastrum,Adonis aestivalis,Cylindrotheca closterium,Chaetoceros sp.,Scenedesmus sp. almeriensis,Odontella aurita,Coelastrella striolata,Vischeria stellata,Isochrysis aff. galbana,Paralia longispina,Scenedesmus bijugus,Mallomonas sp.,Nitzschia cf. carinospeciosa,Cyclotella cf. cryptica,Stephanocyclus meneghinianus,Padina minor,Coelastrella striolata var. multistriata,Helicobacter pylori,Synechococcus elongatus PCC 6301,Arthrospira platensis,Limnospira maxima,Synechococcus sp. WH 7803,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Dipturus trachyderma,Osphranter robustus)
• Factors (molecules and mechanisms) regulated by carotenoids, resulting in their anti-carcinogenic effects (2018, Nicotiana tabacum,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Candida dubliniensis,Embryophyta,PX clade,Phaeodactylum tricornutum,Nitzschia alba,Chlorella vulgaris,Haematococcus lacustris,Dunaliella salina,Chlorella sorokiniana,Galdieria sulphuraria,Chlorella sp.,Nannochloropsis sp.,Porphyridium purpureum,Chromochloris zofingiensis,Auxenochlorella pyrenoidosa,Auxenochlorella protothecoides,Botryococcus braunii,Parachlorella kessleri,Pseudochlorella pringsheimii,Sargassum siliquastrum,Adonis aestivalis,Cylindrotheca closterium,Chaetoceros sp.,Scenedesmus sp. almeriensis,Odontella aurita,Coelastrella striolata,Vischeria stellata,Isochrysis aff. galbana,Paralia longispina,Scenedesmus bijugus,Mallomonas sp.,Nitzschia cf. carinospeciosa,Cyclotella cf. cryptica,Stephanocyclus meneghinianus,Padina minor,Coelastrella striolata var. multistriata,Helicobacter pylori,Synechococcus elongatus PCC 6301,Arthrospira platensis,Limnospira maxima,Synechococcus sp. WH 7803,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Dipturus trachyderma,Osphranter robustus)
• AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity (2018, Bos taurus,Canis lupus familiaris,Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Impact of MK2- and IKK-dependent phosphorylation on RIPK1 function (2018, NA)
• Tuning the depth of quiescence for cancer therapy (2018, Homo sapiens)
• Proteomic analysis of the genes in Xllp08 and wild-type E (2018, Escherichia coli,Homo sapiens)
• Activation of the B cell receptor signaling canonical pathway in FCRx versus SIS: a schematic representation (2018, Homo sapiens)
• KSHV entry by macropinocytosis and trafficking in the human microvascular dermal endothelial cells (2018, NA)
• Propranolol, a lipophilic Beta-AR antagonist that crosses the blood–brain barrier, targets Beta-ARs in the amygdala (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Apis mellifera)
• Heparan sulfate proteoglycan (HSPG) protein family organization and HS biosynthesis (2018, NA)
• Transcriptome profiling identified differentially expressed genes and pathways associated with tamoxifen resistance in human breast cancer (2018, Homo sapiens,Mus musculus)
• Melatonin attenuated brain death tissue extract-induced cardiac damage by suppressing DAMP signaling (2018, NA)
• LncRNA Gas5 acts as a ceRNA to regulate PTEN expression by sponging miR-222-3p in papillary thyroid carcinoma (2018, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Bacillithiol in Gram-Positive Firmicutes (2018, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Bacillus subtilis,Corynebacterium glutamicum,Bacillus subtilis At2,Bacillus anthracis,Streptomyces coelicolor,Mycobacterium tuberculosis variant bovis,Bacillus cereus,Bacillus amyloliquefaciens,Priestia megaterium,Streptococcus agalactiae,Deinococcus radiodurans,Paracoccus denitrificans,Streptomyces clavuligerus,Bacillus pumilus,Bacillus methanolicus,Staphylococcus aureus subsp. aureus COL,Staphylococcus aureus subsp. aureus NCTC 8325,Staphylococcus carnosus,Bacillus methanolicus MGA3,Streptomyces sp. AJ9463,Saccharomyces cerevisiae,Claviceps purpurea,Homo sapiens,Mus musculus,Bos taurus,Leishmania donovani)
• PD173074 inhibits the signal pathway downstream of FGFR1 in ESCC (2018, NA)
• Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma (2018, NA)
• Prediction of reaction knockouts to maximize succinate production by Actinobacillus succinogenes (2018, NA)
• Representation of the DNA methylation modifications that occurred within the PI3K/AKT KEGG pathway following 7 weeks of reloading in human subjects (2018, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Danio rerio)
• Cross-talk of mTOR with other signaling pathways (2018, Mus musculus,Homo sapiens)
• Key players in the mammalian autophagy pathway discussed in this review (2018, NA)
• Signal transduction through the mTOR complexes (2018, NA)
• Lipid Metabolism and Lipid Droplets in Pancreatic Cancer and Stellate Cells (2018, NA)
• Central pathway for fatty acid and cholesterol synthesis (2018, NA)
• Interplay between Selenium Levels and Replicative Senescence in WI-38 Human Fibroblasts: A Proteomic Approach (2018, NA)
• Simplified relationship between ROS-induced redox signaling and mitochondrial dynamics (2018, NA)
• Role for proteasome inhibition in the modulation of fibrogenic mechanisms mediated by RPE cells (2018, NA)
• Role of ginsenosides in reactive oxygen species-mediated anticancer therapy (2018, NA)
• IL-36 cytokines in autoimmunity and inflammatory disease (2018, Escherichia coli,Porphyromonas gingivalis,Homo sapiens,Mus musculus)
• Gene master regulators of papillary and anaplastic thyroid cancers (2018, NA)
• Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans)
• Illustrating diagram for several growth factors and signaling molecules that regulate different stages of satellite cells (2018, NA)
• Antioxidant mechanisms of pyruvate (2018, Homo sapiens,Canis lupus familiaris)
• Inclusion membrane proteins and secreted effectors from C (2018, Chlamydia trachomatis,Homo sapiens)
• Effect of nutrients at the interface of host immunity (2018, NA)
• Gut microbes on innate immune receptor (2018, NA)
• Current research on head and neck cancer-associated long noncoding RNAs (2018, NA)
• Current research on head and neck cancer-associated long noncoding RNAs (2018, NA)
• Drug resistance related to aberrant glycosylation in colorectal cancer (2018, Homo sapiens)
• Drug resistance related to aberrant glycosylation in colorectal cancer (2018, Homo sapiens)
• Drug resistance related to aberrant glycosylation in colorectal cancer (2018, Homo sapiens)
• 3D modeling of cancer stem cell niche (2018, NA)
• KSHV LANA upregulates the expression of epidermal growth factor like domain 7 to promote angiogenesis (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Human gammaherpesvirus 8,Vesicular stomatitis virus,Avian erythroblastosis virus E26,Homo sapiens,Mus musculus,NA)
• Proposed regulatory pathway for astragaloside IV action in inhibition of adipose lipolysis (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Astragalus membranaceus)
• HIV replication in monocyte derived macrophages (MDM) by steroid hormones (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,Vesicular stomatitis virus,Measles morbillivirus,Human alphaherpesvirus 2,HIV-1 group M,Homo sapiens,Macaca mulatta,Sequoia sempervirens,Simian-Human immunodeficiency virus)
• 5-HT2Asignaling pathways (2018, NA)
• Proposed mechanisms for C-phycocyanin-induced apoptosis, migration and cell cycle arrest in MDA-MB-231 cells (2018, NA)
• Critical comparison of topology-based pathway analysis methods (2018, NA)
• Inferring hidden causal relations between pathway members using reduced Google matrix of directed biological networks (2018, NA)
• Inferring hidden causal relations between cancer and normal networks (2018, NA)
• Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Radiation effects on antitumor immune responses: current perspectives and challenges (2018, NA)
• Phenylalanine regulates initiation of digestive enzyme mRNA translation in pancreatic acinar cells and tissue segments in dairy calves (2018, NA)
• TIPE1 and Wnt/beta‐catenin signalling pathway in gastric cancer (2018, Homo sapiens,Mus musculus,Bos taurus)
• Signalling pathways involved in HMGB1‐induced HIF‐1A expression and angiogenesis in human TMJ perforated disc cells (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Network of differentially expressed proteins in KD with CAD and CAA (2018, NA)
• Ingenuity pathway analysis network identified with differential expressed genes (2018, NA)
• Construction and analysis of the HEV-host PPI network (2018, Human alphaherpesvirus 1,unidentified influenza virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Enterovirus C,Tobacco mosaic virus,Lyssavirus rabies,Infectious bronchitis virus,SARS coronavirus NS-1,Turnip mosaic virus,Cricket paralysis virus,Norwalk virus,Felid alphaherpesvirus 1,Saccharomyces cerevisiae,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Oryza sativa,Sus scrofa,Escherichia coli BL21,Escherichia coli 27A,Homo sapiens,Mus musculus,NA,NA)
• Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the influenza A pathway (2018, NA)
• Differentially expressed genes (red) in the neonatal respiratory distress syndrome group compared with the control group in the TNF signaling pathway (2018, NA)
• Co-expression network constructed for the signature genes (2018, NA)
• Convergence of miR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells (2018, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Psidium guajava,Homo sapiens,Mus musculus,Meleagris gallopavo,murine stem cell retroviral vector)
• The Axl signaling pathway (2018, NA)
• Interaction of miRNAs as oncogenic and tumor suppressor (2018, Homo sapiens)
• Biological pathways that engage TDP1 and TDP2 (2018, Human immunodeficiency virus 1,Hepatitis B virus,Enterovirus C,Coxsackievirus B3,Coxsackievirus,Human rhinovirus sp.,Duck hepatitis B virus,Mus musculus,Saccharomyces cerevisiae,Gallus gallus,Danio rerio,Schizosaccharomyces pombe,Cricetulus griseus,Homo sapiens,Caenorhabditis elegans)
• Assembly of estrogen receptor/androgen receptor/Src ternary complex (2018, NA)
• Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy (2018, Homo sapiens,Gallus gallus,NA)
• Signaling pathway responding to oligodeoxynucleotides of class C (2018, Homo sapiens)
• Proposed signaling pathway (2018, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Panax ginseng,Glycyrrhiza uralensis,Homo sapiens)
• PNU attenuates nicotine plus HFD–induced hepatic steatosis (2018, NA)
• MAPK signaling pathway, where each MAPK phosphorylates several transcriptional factors, regulating protein expression (2018, NA)
• DEGs enriched KEGG map of the TNF signaling pathway in myocardial infarction (2018, NA)
• DEGs enriched KEGG map of the NFKB signaling pathway in myocardial infarction (2018, NA)
• Osteoclast differentiation signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Porphyromonas gingivalis,Bactrocera dorsalis)
• Cellular model of insulin (and leptin) signaling via TRPC5 channel activation in POMC neurons (2018, Mus musculus,Cavia porcellus,Homo sapiens)
• Proposed mechanisms underlying the action of TBN on promoting post‐ischaemic neuroregenerative repair in cerebral ischaemic environment (2018, Rattus norvegicus,Homo sapiens)
• Mechanism of anti-allergic and inflammatory effect of quail egg on the food allergy induced EoE like disease alergic reaction (2018, NA)
• Schematic to illustrate calcimimetic R-467 reversed Cd-induced signaling pathways, followed reinstated intracellular Ca2+ level and ROS generation, restored autophagic flux, alleviated cell apoptosis and stimulated cell proliferation (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Anguilla japonica)
• Signalling pathway impact analysis of gene expression data from H226 MM cells expressing C91A-mutant (mt BAP1) or wild-type BAP1 (wt BAP1) (2018, NA)
• Histological subtypes of mouse mammary tumors reveal conserved relationships to human cancers (2018, NA)
• The transforming growth factorB1/Smad signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Mechanism through which metformin exerts its antitumor effects (A) by reducing the level of insulin in serum to inhibit the PI3K/Akt/mTOR signaling pathway and (B) by activating AMPK to inhibit the mTOR pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• ORI inhibits TGFB1-induced EMT of melanoma cells through PI3K/Akt/GSK-3B signaling pathway (2018, NA)
• Pathway studio analysis of proteins whose genes were analysed in the study by the gene array analysis and qPCR (2018, NA)
• Pathway studio analysis of genes analyzed in the study by the gene array analysis and qPCR (2018, NA)
• How the ∆133p53 isoform regulates the JAK-STAT3 and RhoA-ROCK pathways to promote inflammation and invasion (2018, NA)
• Schematic drawing of the interactions between AB(1‐42) and IGF‐I receptor signaling (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of important signaling pathways by E3 ubiquitin ligases in CRC (2018, Danio rerio,Xenopus laevis,Argyrosomus regius,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Ovis aries)
• Regulation of Wnt/Beta-catenin signaling and oncogenic NFKB pathway by ubiquitylating enzymes in CRC (2018, Danio rerio,Xenopus laevis,Argyrosomus regius,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Ovis aries)
• Model depicting the suggested signaling pathway modulated by CSs to inhibit HIV-1 gene expression (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Diaporthe sclerotioides)
• Changes in brain energy metabolism during worker maturation elucidated by pathway analysis of data from brain RNA-seq experiments (2018, Apis cerana,Homo sapiens)
• Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus (2018, NA)
• Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus (2018, NA)
• Neurotransmitters signalling pathways in cancer (2018, Mus musculus,Rattus norvegicus,Homo sapiens)
• Gcn5−/− EBs becomes evident early during EB differentiation (2018, Saccharomyces cerevisiae,Bos taurus,Equus asinus,Stellaria media,Homo sapiens,Mus musculus,Drosophila melanogaster,Corynebacterium phage gamma)
• Regulation of hepatic gluconeogenesis.Notes: In prolonged fasting, hepatic gluconeogenesis is initiated and catalyzed by a series of enzymes including PC, PEPCK, FBPase and G6Pase (2018, NA)
• Regulation of hepatic glycogenolysis.Notes: Under fasting condition, hepatic glycogenolysis is enhanced via an increased concentration of glucagon and epinephrine (2018, NA)
• Canonical neuropathic pain signaling pathway (2018, NA)
• Putative inhibitory pathway of BIOGF1K-mediated antiphotoaging events (2018, Panax ginseng,Homo sapiens)
• Phenylephrine synthesis (2018, Saccharomyces cerevisiae,Eucalyptus intertexta,Komagataella pastoris,Citrus sinensis,Escherichia coli,Pseudomonas putida,Streptomyces coeruleorubidus,Homo sapiens,Mocyta fungi)
• Activators and repressors of the regulatory network of genes associated with the bovine milk K-casein content (2018, NA)
• Expression of key biological pathways involved in M (2018, Mycobacterium tuberculosis,Homo sapiens)
• Methylene-tetrahydrofolate reductase contributes to allergic airway disease (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Hepatitis B virus)
• Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway (2018, Mus musculus,Rattus norvegicus,Armoracia rusticana,Zea mays,Homo sapiens)
• PPARG signaling (2018, NA)
• Mucosal tolerance in the gut and its breakdown in food allergy (2018, Bos taurus,Salmonella enterica subsp. enterica serovar Typhimurium,Bacteroides fragilis,Eutheria,Homo sapiens,Mus musculus,Respiratory syncytial virus,Arachis hypogaea)
• Developmentally regulated signaling pathways in glioma invasion (2018, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• DENV2-induced autophagy is ER stress-UPR dependent, involving PERK-eIF2Alpha-ATF4 and IRE1Alpha-JNK-BECN1 pathways (2018, Dengue virus,West Nile virus,Japanese encephalitis virus,Mus musculus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris,NA)
• Trans10,cis12 conjugated linoleic acid inhibits proliferation and migration of ovarian cancer cells by inducing ER stress, autophagy, and modulation of Src (2018, NA)
• TGF-Beta-induced fibrosis signaling pathway (2018, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Glycine max)
• Pathway map for “Inhibitory PD-1 signaling in T cells” (2018, Mycobacterium tuberculosis,Homo sapiens)
• ROP signaling pathways (2018, NA)
• Putative function of a Glutathione-S-transferase in the formation of PEN2 pathway end products (2018, Arabidopsis thaliana,Colletotrichum gloeosporioides,Plectosphaerella cucumerina,Erysiphe pisi,Opsanus beta,Homo sapiens)
• Activation signals of inflammasomes (2018, NA)
• Antitumor and protumor functions of GD T cells (2018, NA)
• Signaling pathway activated by piperonylic acid (2018, NA)
• Kegg PI3K/Akt‐Signaling pathway with highlighted dysregulated mRNA and their associated seed‐region matched miRNA (2018, NA)
• Schematic model for EGFR-PI3K/AKT signaling activation induced by Notch1C1133Y mutation (2018, NA)
• KRAS/TGFB/p15Ink4b pathway controls the cell fate (2018, NA)
• Top section: Mechanisms responsible for the cytoprotective and anti‐inflammatory effects of PARP inhibitors on non‐oncological diseases (2018, NA)
• Current and proposed molecular mechanisms augmenting myogenic reactivity in subarachnoid hemorrhage (2018, NA)
• Circadian clocks: from stem cells to tissue homeostasis and regeneration (2018, NA)
• An Unexpected Friend – ROS in Apoptosis-induced Compensatory Proliferation: implications for regeneration and cancer (2018, NA)
• The Keap1–Nrf2–ARE pathway (2018, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Armoracia rusticana,Vasconcellea candicans,Anatrytone logan,Homo sapiens)
• Important growth factors and cellular signalling pathways involved in tumourigenesis and angiogenesis of NETs (2018, NA)
• Proposed metabolic pathway of regorafenib in humans in vivo (2018, Homo sapiens,Matthiola incana)
• Relation between activated WNT/Beta-catenin pathway and Warburg effect in ASD (2018, NA)
• DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages (2018, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human adenovirus 5,Simian immunodeficiency virus,Human immunodeficiency virus 2,Semliki Forest virus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Matthiola incana)
• Wnt signalling pathways and their interactions (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Hypothesized signal transduction pathway at germinating A (2018, Aspergillus flavus,Homo sapiens)
• The WNT signaling pathway activated by PRP (2018, NA)
• The putative mechanism involved in the transdifferentiation from SESCs to CECs (2018, Oryctolagus cuniculus,Capra hircus,Ovis aries,Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Sequoia sempervirens)
• Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression (2018, NA)
• Pathways regulating senescence-mediated arrest (2018, NA)
• Regulation of reproduction and longevity by nutrient-sensing pathways (2018, Canis lupus familiaris,Panthera leo,Ursus maritimus,Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta)
• Protein sequestration at the nuclear periphery (2018, Mus musculus,Rattus norvegicus,Danio rerio,Fundulus heteroclitus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Oncogenic regulation of glucose flux into PPP (2018, Homo sapiens,Rattus norvegicus,Eucalyptus intertexta,NA)
• Proposed model shows that MTH-3 induces G2/M phase arrest, autophagy and apoptotic cell death (death receptor/mitochondrial pathways and ER stress) in human breast adenocarcinoma MDA-MB-231 cells (2018, NA)
• Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters (2018, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens)
• Signaling pathways involved in the pathogenesis of MPNs and secondary AML (2018, Homo sapiens,Mus musculus,Escherichia coli,unidentified,Eucalyptus intertexta)
• Hippo signalling pathway in Drosophila and mammals (2018, NA)
• The NLRP3 inflammasome in ORKD development (2018, Mus musculus,Rattus norvegicus,Candida dubliniensis,Triticum aestivum,Homo sapiens,Shigella flexneri)
• Regulation of the FoxO1/3 activity by phosphorylation (2018, Homo sapiens,Mus musculus)
• Cell entry and innate immune response (2018, NA)
• Mechanisms leading to transitory or sustained PD-1 expression in activated and exhausted T cells (2018, NA)
• IGF1R signaling pathway and its relevant drug resistance mechanisms: Promoting proliferation, inhibiting apoptosis and inducing changes to ABC transporter proteins and the ECM (2018, Homo sapiens)
• Functional mechanism of the Notch signaling pathway (2018, NA)
• NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism (2018, NA)
• Interactions between the Wood-Ljungdahl pathway, the Embden-Meyerhof-Parnas glycolytic pathway, and the mevalonic acid pathway for the synthesis of isoprene (2018, NA)
• Alternative signaling pathways of GFLs (2018, NA)
• Extrinsic and intrinsic apoptotic pathways (2018, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• P53–p21–DREAM–E2F/CHR pathway (2018, NA)
• Scheme of reported cross-talk between core Hippo pathway components and wt (left) or mutant (right) p53 (2018, NA)
• Cardioprotective effect of CAPE-oNO2 (2018, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,H14N2 subtype)
• Cell–cell communication by extracellular vesicles in multiple myeloma (2018, NA)
• Depicting the possible molecular mechansims by which MitoQ prevents alcoholic liver disease through modulating ALDH2 posttranslational modifications (2018, NA)
• DJ-1 activates ERK1/2 signaling pathway (2018, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• PKR signaling pathways that are activated by inflammatory stimulation (2018, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Cholesterol synthesis and cancer cell proliferation (2018, NA)
• Reactome functional interaction network corresponding to 520 genes showing differential expression in the T0 (fasting) vs T2 (7 h after eating) comparisons (2017, NA)
• Lipoquality control by phospholipase A2 enzymes (2017, Homo sapiens)
• The regulation of meiosis resumption by ARPP19 in Xenopus oocytes (2017, Xenopus laevis,Homo sapiens)
• Toll-like receptor (TLR) stimulation, signaling, and immunological outcomes (2017, NA)
• General diagram of Cu‐responsive paths in the cells of filamentous fungi at the proteome level (2017, Penicillium janthinellum,Homo sapiens)
• Network analysis of the gene pathways* catalogued in the Panther database, which - directly or indirectly - are connected with AD upon activation with Hp(2-20) (2017, NA)
• Schematic overview of the metabolism and material transport in Achromobacter sp (2017, NA)
• Terminal oxidation pathway for n-alkane degradation in Achromobacter sp (2017, NA)
• Cholinergic anti-inflammatory pathway (CAP) (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Chlamydomonas reinhardtii,Mustela putorius furo,Merluccius merluccius)
• Cytoscape pathway visualizations of lipid metabolites modulated by navy bean, rice bran, or navy bean + rice bran consumption (2017, Oryza sativa,Diaporthe sclerotioides,Allium cepa,Phaseolus vulgaris,Homo sapiens,Rattus norvegicus)
• Fatty acid synthesis in Mortierella alpina (2017, Mortierella alpina,Homo sapiens)
• Abl Kinase Regulation by BRAF/ERK and Cooperation with Akt in Melanoma (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation (2017, NA)
• Interaction between stress responses and circadian metabolism in metabolic disease (2017, Mus musculus,Rattus norvegicus,Homo sapiens,human metagenome,Procambarus clarkii)
• Generation of ROS as a result of incident radiation affecting the mitochondrion.Notes: ROS have been shown to form oxidative DNA adducts, such as 8-OHdG, which in turn can lead to base modifications and transversions, such as GC to TA (2017, Saccharomyces cerevisiae,Armoracia rusticana,Schizosaccharomyces pombe,Eleutherococcus senticosus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Caenorhabditis elegans,Dipturus trachyderma)
• Consequences of altered cardiac metabolism on non-energy providing functions (2017, NA)
• Schematic summarizing findings and proposed mechanism of placental lipid metabolism in obese women (2017, NA)
• Mitogen-activated protein kinase signaling pathway (2017, NA)
• How Reactive Oxygen Species contribute to insulin resistance (2017, NA)
• Role of SDC-4 in the regulation of the integrin and FGF signaling pathways (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Regulation of ΔF508 CFTR stability by inhibitors to the PI3K/Akt/mTOR pathway (2017, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Proposed miRNA-dependent regulatory pathway that participate in wheat male fertility transition (2017, Arabidopsis thaliana,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Triticum aestivum,Arachis hypogaea,Cucumis sativus,Medicago sativa,Raphanus sativus,Brassica rapa,Brassica juncea,Lilium longiflorum,Eutrema halophilum,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Cucumber mosaic virus)
• Proposed model for the mechanism through which wild-type (wt) and lab-attenuated rabies virus (RABV) infect astrocytes (2017, Human immunodeficiency virus 1,Influenza A virus,Human immunodeficiency virus,Vesicular stomatitis virus,Measles morbillivirus,Lyssavirus rabies,Ebola virus sp.,Theilers encephalomyelitis virus,Avian myeloblastosis virus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Lasionycteris noctivagans,Mus musculus,Rattus norvegicus,Homo sapiens,prion,NA,NA)
• Physiological regulation of autophagy in the heart (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans)
• Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Xenopus tropicalis)
• Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Xenopus tropicalis)
• Vascular Endothelial Growth Factor A and Leptin Expression Associated with Ectopic Proliferation and Retinal Dysplasia in Zebrafish Optic Pathway Tumors (2017, NA)
• Salmonella enterica serovar-specific transcriptional reprogramming of infected cells (2017, NA)
• 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice (2017, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Scutellaria barbata,Garcinia kola,Homo sapiens,Escherichia coli)
• HN inhibits OS and ER stress in RPE by direct and indirect mechanisms (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Checkpoint inhibitors in melanoma and early phase development in solid tumors (2017, NA)
• Molecular pathways of macrophage polarization (2017, NA)
• H3K79 methylation pathway and potential therapeutic targets (2017, NA)
• Rotavirus interactions with the host innate system: viral entry into cells and viral double strand RNA (dsRNA) induce the generation of pathogen-associated molecular pathways (PAMPs) (2017, Lacticaseibacillus casei,Limosilactobacillus reuteri,Lactobacillus acidophilus,Bifidobacterium longum,Lacticaseibacillus rhamnosus GG,Streptococcus thermophilus,Bacteroides thetaiotaomicron,Bifidobacterium adolescentis,Bifidobacterium breve,Bifidobacterium longum subsp. infantis,Bifidobacterium animalis subsp. lactis,Ligilactobacillus ruminis SPM0211,Human rotavirus,Rotavirus A,Porcine rotavirus,Murine rotavirus,Aichivirus A,Rotavirus B,Bovine rotavirus A unknown G-type,WA-like,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Saccharomyces boulardii nom. inval.)
• RV infection and pathogenesis: virus entry, formation of viroplasms and replication, and release of virions and viral proteins such as NSP4; this protein mobilizes intracellular calcium from endoplasmic reticulum (ER) (2017, Lacticaseibacillus casei,Limosilactobacillus reuteri,Lactobacillus acidophilus,Bifidobacterium longum,Lacticaseibacillus rhamnosus GG,Streptococcus thermophilus,Bacteroides thetaiotaomicron,Bifidobacterium adolescentis,Bifidobacterium breve,Bifidobacterium longum subsp. infantis,Bifidobacterium animalis subsp. lactis,Ligilactobacillus ruminis SPM0211,Human rotavirus,Rotavirus A,Porcine rotavirus,Murine rotavirus,Aichivirus A,Rotavirus B,Bovine rotavirus A unknown G-type,WA-like,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Saccharomyces boulardii nom. inval.)
• Inflammation, apoptosis and cell survival (2017, NA)
• Essential metabolites (2017, NA)
• Multimodal Imaging of Neurometabolic Pathology due to Traumatic Brain Injury (2017, NA)
• Insulin receptor signaling pathway including ROS influence (2017, NA)
• Hepatitis C virus-apolipoprotein interactions: molecular mechanisms and clinical impact (2017, Homo sapiens,Pan troglodytes,Rattus norvegicus,NA,NA)
• Alternative pathway of calcitonin gene‐related peptide (CGRP) for treatments of Alzheimer's type dementia (2017, NA)
• In response to injury, there are significant and dynamic changes to the OGlcNAc sub-proteome (2017, NA)
• New perspectives for targeting RAF kinase in human cancer (2017, NA)
• p53 signaling pathway and related significant changes observed in response to postprandial serum (orange: upregulated compared to fasting serum; green: downregulated compared to fasting serum) (2017, Solanum tuberosum,Olea europaea,Salvia rosmarinus,Musa ABB Group,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Escherichia coli,Gallus gallus)
• Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals (2017, Solanum tuberosum,Olea europaea,Salvia rosmarinus,Musa ABB Group,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Escherichia coli,Gallus gallus)
• TLR signaling and downstream molecules (2017, NA)
• Insulin signaling pathway (2017, Homo sapiens,Rattus norvegicus)
• Synopsis of significant mitogen-activated protein kinase (MAPK) signaling pathway in the dentate gyrus (DG) of mice exposed to MPTP according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Mouse mammary tumor virus,Enterovirus C,Homo sapiens,Armoracia rusticana)
• Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Mouse mammary tumor virus,Enterovirus C,Homo sapiens,Armoracia rusticana)
• Hypothetical model for the proposed anti-inflammatory role of MUC1 in response to P (2017, NA)
• Catechins show an inhibition of the MAPK cascade pathway through the inhibition of the phosphorylation of ERK1/2, JNK, and p38 (2017, NA)
• Cartoon depicts the role of MYBL2 and FoxM1 in glioma progression (2017, NA)
• MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells (2017, Homo sapiens)
• Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy (2017, NA)
• Graphene oxide and reduced graphene oxide induced neural pheochromocytoma-derived PC12 cell lines apoptosis and cell cycle alterations via the ERK signaling pathways (2017, NA)
• Reconstructing the regulatory circuit of cell fate determination in yeast mating response (2017, Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice (2017, Mus musculus,Rattus norvegicus,Peromyscus sejugis,Oryctolagus cuniculus,Equus asinus,Homo sapiens)
• Complications and management of coagulation disorders in leukemia patients (2017, NA)
• Structure and function of ARNAX (2017, NA)
• NDRG1 inhibits oncogenic signaling pathways by down-regulating the ErbB family of receptors (2017, NA)
• Simplified representation of a signaling cascade (2017, Saccharomyces cerevisiae,Beta vulgaris,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Summary of signaling pathways regulating Piezo channels (2017, NA)
• TGFB signaling pathway (2017, Homo sapiens,Mus musculus,Citrus macrophylla)
• Conceptual model of four networks believed to be involved in pain processing and pain interpretation (2017, Homo sapiens)
• List of 24 CMMDh genes (left), genes enriched to the top canonical signaling pathways (middle) and the network of these genes with mood disorders and the CMD-Rs (right) (2017, NA)
• Proposed model of dopamine dysregulation in the nigrostriatal pathway in schizophrenia (2017, NA)
• Mechanisms of celebrex-mediated apoptosis (2017, NA)
• Diabetic endothelial cell metabolismIn diabetic ECs, hyperglycemia increases production of ROS through a variety of intracellular sources, including NADPH oxidase, xanthine oxidase, uncoupled eNOS, and impaired pentose phosphate pathway (PPP) (2017, NA)
• Normal endothelial cell metabolismA schematic of the principal pathways in healthy EC metabolism and the rate-limiting enzymes, carriers, and transporters (shown in blue) (2017, NA)
• Purinergic pathway (2017, NA)
• DAB2IP and RASAL2 Cooperate to Drive Distinct Aspects of Metastasis Through Ras and NFKB (2017, Homo sapiens,Mus musculus,Mouse mammary tumor virus,Bikinia letestui)
• Glucose and glutamine catabolism provide tumor cells with biosynthetic precursors (2017, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus,Gallus gallus)
• Classical and “back-door” pathways of androgen biosynthesis (2017, NA)
• Role of 1,25(OH)2D3 in myofibroblast differentiation and extracellular matrix deposition in TGFB1-induced nasal polyp-derived fibroblasts and nasal ex vivo organ culture (2017, NA)
• Pathophysiological events involving astrocytes in AD (2017, Homo sapiens)
• GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Pekania pennanti)
• Protein complex analysis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Merged mouse and rat network (mapped to human proteins) and overlapping Reactome pathways (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• A2AR and baicalin attenuated hypoxia-induced PAH (2017, NA)
• Proposed mechanism of hypoxic-conditioned secretome effects on liver regeneration (2017, NA)
• Oxidative phosphorelation metabolic pathway (2017, NA)
• Molecular mechanism of the mTOR pathway in Vil‐Cre;Pkd2 f3/f3 mice, with or without rapamycin treatment (2017, NA)
• Differentially active pathways across pan-urologic genomic subtypes (2017, Homo sapiens,Hylobates sp.,Mus musculus,Erythroxylum coca,Transposon gamma-delta)
• Gonadotropin-releasing hormone (GnRH) receptor signal transduction in human cancers (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus)
• B‐catenin promotes the fibroblast‐to‐myofibroblast transition and EMT through the activation of the TGF‐B1/Smad2/3 signalling pathway (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Localization of the polycystic kidney disease (PKD) proteins, the pathways implicated in its pathogenesis, and putative therapeutic targets (2017, NA)
• Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge (2017, NA)
• miR-133b/206 Associates with Various Genes Mediating NSCLC Cell Migration and InvasionmiR-206 promoted lung cancer cell apoptosis by targeting c-Met and Bcl2, as well as governed EGFR, MET, and its downstream phosphorylation of ERK1/2 and AKT (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Quantitative proteomics profiling reveals activation of mTOR pathway in trastuzumab resistance (2017, NA)
• Effect of rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS) (2017, NA)
• Simplified diagrams of putative signaling pathways responsible for the different migration patterns (i.e (2017, NA)
• Graphical Summary (2017, Mus musculus,Rattus norvegicus,Armoracia rusticana,Vasconcellea candicans,Homo sapiens,Oryctolagus cuniculus,Antarctothoa delta)
• Microvesicles (MVs) on the early stages of atherosclerosis development (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Candida dubliniensis)
• Mechanisms involved in initiation, perpetuation, and resolution of inflammatory responses (2017, NA)
• Systematic analysis of key factors in the mitochondria-associated innate immunity pathway, using acute starvation of human SH-SY5Y neuroblastoma cells to reveal the transcriptional regulation of stress responses and their dependence on PINK1 (2017, Hepatitis B virus,Human betaherpesvirus 5,DNA viruses,Enterovirus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Gallus gallus,Ovis aries,prion,Sisyrinchium striatum)
• Details from the STRING interaction diagrams within the global transcriptome profiles of Pink1-deficient mouse cerebellar tissue (2017, Hepatitis B virus,Human betaherpesvirus 5,DNA viruses,Enterovirus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Gallus gallus,Ovis aries,prion,Sisyrinchium striatum)
• Effect of selecting different subsets of CpG sites in the “TNF signaling pathway” (2017, NA)
• “cytokine-cytokine receptor interaction” subsection of the “pathways in cancer” pathway, with (a) DNA methylation data, and (b) gene expression data (2017, NA)
• Snapshot of PiiL in group-wise view mode, showing the “cell cycle” pathway (2017, NA)
• TREM2 signaling and function (2017, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Mycobacterium tuberculosis variant bovis BCG,Campylobacter jejuni,Francisella tularensis,Bordetella pertussis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Cricetulus griseus,Coccoloba uvifera,Homo sapiens,Human alphaherpesvirus 1,prion,Mouse mammary tumor virus,unidentified,Macaca fascicularis)
• Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system (2017, NA)
• Proposed mechanistic scheme of MUC13 regulating NFKB activation, related to , , and (2017, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKCζ pathway (2017, Homo sapiens,Mus musculus,Zea mays)
• Illustration of AHR activity in pituitary cells (2017, NA)
• Antibody-dependent enhancement (ADE) of Zika virus (ZIKV) and strategies to limit it (2017, Zika virus,Saccharomyces cerevisiae,Salvia rosmarinus,Glycyrrhiza glabra,Psidium guajava,Azadirachta indica,Andrographis paniculata,Tinospora cordifolia,Boesenbergia rotunda,Trachyspermum ammi,Alternanthera philoxeroides,Actaea racemosa,Euphorbia hirta,Populus balsamifera,Eupatorium perfoliatum,Mammea americana,Azadirachta indica var. indica,Tabernaemontana cymosa,Human immunodeficiency virus 1,Human papillomavirus,Dengue virus,H1N1 subtype,West Nile virus,Ebola virus,Japanese encephalitis virus,Human alphaherpesvirus 2,Chikungunya virus,Yellow fever virus,Dengue virus type 2,SARS coronavirus NS-1,Aurantiochytrium single-stranded RNA virus 01,Modoc virus,Escherichia coli,Staphylococcus aureus,Escherichia coli O6H16CFAII str. B2C,Streptomyces nanchangensis,Homo sapiens,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Capra hircus,Macaca mulatta,Aedes aegypti,Aedes albopictus,Triportheus paranensis,uncultured cyanobacterium,NA,NA)
• Cellular Mechanisms of Estrogen Action (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Interaction pathway of miR-1270 and target genes (2017, NA)
• Cellular processes altered by colonization by a heterologous symbiont: (A) oxidative stress response; (B) molecular signaling pathways; (C) sugar storage, transport, and signaling; and (D) lipid and protein metabolism and transport (2017, NA)
• VEGF/VEGFR signaling and the approved therapeutic agents targeting this signaling (2017, NA)
• Primary immune checkpoint inhibitors in cells (2017, NA)
• PD-1 pathway signaling and the targeting of the PD-1 pathway during cancer immunotherapy (2017, NA)
• Oxygen regulation of ESC metabolism and epigenetic landscape (2017, NA)
• Highlighted genes to represent a single pathway (2017, Homo sapiens)
• Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Leuciscus leuciscus)
• Signalling pathways underlying excitation-contraction coupling (2017, Mus musculus,Homo sapiens)
• Estrogen receptor action (2017, Homo sapiens)
• Overview of the pathogenic model of C. difficile infection (2017, Escherichia coli,Clostridioides difficile,Clostridioides difficile 630,Clostridioides difficile CD46,Clostridioides difficile QCD-32g58,Homo sapiens,Mus musculus,gut metagenome)
• Host/pathogen cross-talk mechanism through core pathways at the early stage of C (2017, Escherichia coli,Clostridioides difficile,Clostridioides difficile 630,Clostridioides difficile CD46,Clostridioides difficile QCD-32g58,Homo sapiens,Mus musculus,gut metagenome)
• Representative model of some signaling pathways in a human breast cancer cell (MDA-MB-231) that can be modulated by GCdcPLI (2017, Crotalus durissus collilineatus,Homo sapiens)
• Cell mechanisms by which MPLA prevents inhibition of absorption by LPS in the MTAL (2017, NA)
• Schematic diagram summarized as a possible mechanism of action of melamine causing tubular cell injury via CSR-mediated Ca2+signaling pathway (2017, Sus scrofa,Homo sapiens)
• Endothelial cell metabolism in health and disease: impact of hypoxia (2017, NA)
• FAM3C activates HSF1 to suppress hepatic gluconeogenesis and attenuate hyperglycemia of type 1 diabetic mice (2017, NA)
• Calcineurin–NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy (2017, NA)
• Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway (2017, NA)
• Molecular map of pathways that lead ROS to cause OPC dysfunctioning in SZ (2017, NA)
• PPI network of proteins (A) up- and (B) down-regulated in renal oncocytoma (2017, Saccharomyces cerevisiae,Diaporthe sclerotioides,Vasconcellea candicans,Homo sapiens,Mus musculus,Gallus gallus)
• Outline of the pathway of conversion of arachidonic acid to eicosanoids (2017, NA)
• Underlying mechanisms of n-3 PUFAs protecting metabolic syndrome (2017, NA)
• Schematic representation showing downregulation of miR‐205 by ErbB2 signaling via Ras/Raf/MEK/ERK pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana,murine stem cell retroviral vector)
• Top Ingenuity Pathway Analysis networks associated with genes whose expression is altered by high levels of miRNA expression associated with both TP53 and CpG island methylator phenotypehigh and/or microsatellite instability (2017, Homo sapiens,Human gammaherpesvirus 4)
• APC-dependent role of CtBP in the Wnt/ Beta-catenin pathway (2017, Drosophila melanogaster,Caenorhabditis elegans,Human adenovirus 5,Human adenovirus 2,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Lactobacillus delbrueckii subsp. bulgaricus)
• Transduction of platinum-induced DNA damage: DNA repair or apoptosis (2017, NA)
• The role of mTOR in postnatal islet morphogenesis, maturation and function (2017, NA)
• Benefits of physical exercise (PE) act through or require a healthy, functional endothelium (beige cells) (2017, Homo sapiens)
• G protein-coupled receptor kinase 2 promotes cardiac hypertrophy (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Homo sapiens,Oryctolagus cuniculus,Matthiola incana)
• Schematic of the miR-206 regulatory mechanism during adipogenesis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Armoracia rusticana)
• G-protein signaling of LW pigs (2017, NA)
• Nucleolar response to DNA damage (2017, Mus musculus,Rattus norvegicus,Cricetus cricetus,Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Physarum polycephalum,Homo sapiens,Xenopus laevis)
• Functional overview of ANRIL and pathways (2017, NA)
• Schematic model proposing a differentiated cell as the cell of origin of skin squamous cell carcinoma (SCC) (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Human papillomavirus)
• Schematic diagram showing the pathological cardiac functions of ANKRD1 in relation to hypertrophy, fibrosis and apoptosis (2017, Mus musculus,Rattus norvegicus,Molva molva,Cyprinus carpio,Homo sapiens)
• Redox regulation of Wnt/Beta-catenin signaling pathway and lipid peroxidation (2017, Homo sapiens,Mus musculus,Phleum pratense,Poecilia sphenops)
• Canonical Wnt signaling pathway (2017, Homo sapiens)
• Up-regulation of BIRC3 transcription by NPD1-dependent c-REL expression (2017, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Reticuloendotheliosis virus,Homo sapiens,Danio rerio)
• NPD1 inhibits apoptosis during UOS (2017, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Reticuloendotheliosis virus,Homo sapiens,Danio rerio)
• Biological pathway of Leukocyte Transendothelial Migration () (2017, Homo sapiens)
• Proposed model of changes in epigenetic status before and after establishing hiONs from hiPSCs and epigenetic silencing by hyperglycemia in orexin neurons (2017, NA)
• Rag GTPase-dependent amino acid signaling pathway upstream of mTORC1 (2017, NA)
• Pathway of c-Fos-mediated Lewis y in response to TGFB1 (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human papillomavirus)
• Signaling pathway in the adhesion of stem cells to bone biomaterials (2017, NA)
• Signaling pathways underlying podocyte injury in DN (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• MGluR5 signalling pathway (2017, Camellia sinensis,Aspergillus sp.,Camellia sinensis var. assamica,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Integrated salt response pathway network in P (2017, Populus euphratica)
• TANC protein interaction network (2017, NA)
• Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) (2017, NA)
• Dietary lipids on the hepatopancreas transcriptome of Chinese mitten crab (Eriocheir sinensis) (2017, NA)
• Glabridin on the estrogen pathway (2017, NA)
• Common downstream targets for cancers of the breast (blue dots), colon (green dots), lung (red dots), and prostate (brown dots) (2017, NA)
• Mediation of cellular osteogenic differentiation through daily stimulation time based on polypyrrole planar electrodes (2017, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Leuciscus idus)
• Linking processing of clustered DNA damage and immune response (2017, NA)
• MET regulated signaling pathways implicated in the hallmarks of cancer (2017, NA)
• Schematic and simplified representation of the class I PI3Ks/Akt/mTOR pathway, some of the main cellular functions regulated by it, and the main family of inhibitors targeting it (2017, Xanthosoma sagittifolium,Arthrobotrys janus,Homo sapiens,Mus musculus)
• Schematic diagram showing the RhoA pathway in cryopreservation of dormant murine embryos (2017, NA)
• Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort (2017, Homo sapiens,Mus musculus)
• Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort (2017, Homo sapiens,Mus musculus)
• Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus,Citrus macrophylla)
• KEGG (Kanehisa & Goto, 2000) PI3K-Akt signaling pathway (map04151) is enriched for genes differentially expressed between lesion and healthy lung tissue in cattle challenged with BRDC pathogens (2017, NA)
• Wnt/Beta-catenin signaling in TBI (2017, NA)
• Possible interactions between signaling molecules (2017, NA)
• Scheme of the pathway mediating the VEGF-induced disassembly of adherence junctions and its regulation by NDPK-B (2017, Mus musculus,Homo sapiens)
• Glycolysis is downregulated in idiopathic pulmonary fibrosis (IPF) lungs, with possible shuttling of intermediates to the sorbitol and pentose phosphate pathways (2017, NA)
• Cellular signaling pathways through which NELL-1 works (2017, NA)
• Interactions of genes involved in tumor progression and EMT (2017, NA)
• Action of PPARG ligands and p38 MAPK on transforming growth factor (TGF)B1–induced Beta-catenin signaling in corneal fibroblasts (2017, NA)
• KEGG pathway of apoptosis.Notes: The red-colored genes are differentially expressed genes enriched in the pathway in the study (2017, NA)
• Considering the spectrum of colorectal cancer (CRC)—conventional adenomas progress by the sequential accumulation of genetic mutations and chromosomal instability causing microsatellite stable (MSS) tumours (2017, Diaporthe sclerotioides,Iris germanica,Homo sapiens)
• CXCL12/CXCR4 signaling and related pathways in HCC progression (2017, NA)
• Detailed molecular network of pathways of the cell cycle (Kyoto Encyclopedia of Genes and Genomes ID, has04110) (2017, Nicotiana tabacum,Glycine max,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Action of PGD2 in allergic inflammation (2017, NA)
• Functional involvement of Hh signaling molecules in estrogen- mediated endometrial hyperplasia (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Olea europaea,Homo sapiens,Drosophila melanogaster)
• Representation of the putative signaling pathways involved in B-cell clonogenicity induced by interaction of S75X/p17R76G with p17R(s) (2017, Human immunodeficiency virus 1,Human immunodeficiency virus,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Venustaconcha ellipsiformis,Cerobasis alpha,Antarctothoa delta,Homo sapiens,Mus musculus,Bos taurus)
• The involvement of the brain-derived neurotrophic factor (BDNF)-glycogen synthase kinase-3B (GSK-3B)-Beta-catenin pathway in the antidepressant-like effects of Morinda officinalis oligosaccharides (MOs) and resilience to stress (2017, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,herbal medicine,Gynochthodes officinalis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulatory network for p42.3 involvement in colorectal cancer cell apoptosis (the red pathway indicates the possible acting pathway for p42.3 involvement in cell apoptosis) (2017, Homo sapiens)
• Overcoming glioblastoma adaptation (2017, NA)
• Cell cycle arrest in plants: what distinguishes quiescence, dormancy and differentiated G1? (2017, NA)
• Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications (2017, NA)
• Neuroprotective pathway hypothesized using the canonical targets of compounds that showed synergistic activity (see text for description) (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Matthiola incana,Phleum pratense,Homo sapiens,Mus musculus,Coregonus lavaretus)
• Proposed model (2017, NA)
• RAS–RAF–MEK–ERK pathway is activated in many types of cancer (2017, Homo sapiens,Mus musculus,unidentified)
• Schematic diagram summarizing the regulatory role of the Id1/IGF2/VEGF/VEGFR pathway in esophageal squamous cell carcinoma (ESCC) progression (2017, NA)
• PI3K signaling pathway (2017, Homo sapiens)
• The c-Myc/miR-200b-3p/PRDX2 regulatory loop (2017, NA)
• Mitogen activated protein kinase (MAPK) signaling pathway (2017, Rous sarcoma virus,Avian leukosis virus,Avian retrovirus,Avian sarcoma virus,Avian myelocytomatosis virus 29,Murine sarcoma virus 3611,Avian carcinoma Mill Hill virus 2,Avian myelocytomatosis virus OK10,Avian retrovirus IC10,Homo sapiens,Mus musculus,Gallus gallus,Canis lupus familiaris,Lareunionomyces loeiensis,NA)
• Schematic overview of the TEK signaling pathway which was built with CellDesigner 4.4 (2017, NA)
• MTG16, and other MTG family members, may play a role in the constitutive repression of both Wnt and Notch signaling pathways (2017, NA)
• Hypothetical illustration for the role of CWP (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Melia azedarach,Schisandra chinensis,Prunus mume,Homo sapiens,Mus musculus)
• Interaction between the Wnt and the Notch signaling pathways (2017, herbal medicine,Salvia miltiorrhiza,Panax notoginseng,Ligusticum sinense,Astragalus mongholicus,Polygala tenuifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Dipturus trachyderma)
• Different proteins on the Wnt signaling pathway (2017, herbal medicine,Salvia miltiorrhiza,Panax notoginseng,Ligusticum sinense,Astragalus mongholicus,Polygala tenuifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Dipturus trachyderma)
• Dynamic enrichment analysis identifies context relevant higher level SCPs emerging from interactions of level-3 SCPs (2017, Saccharomyces cerevisiae,Linum usitatissimum,Homo sapiens,unidentified)
• Distribution of differentially expressed genes in astrocytes following hypoxia+ hypothermia vs (2017, NA)
• Regulatory network for p42.3 involvement in tumor cell apoptosis (red pathway indicates the maximally possible acting pathway) (2017, Homo sapiens)
• KRAS‐dependent genetic network analysis (2017, Saccharomyces cerevisiae,Homo sapiens)
• Proposed model for the contribution of JNK, JAK/STAT and Nrf2 pathways to cell competition (2017, NA)
• Extended Kegg Pathway for PI3K-Akt signaling (2017, NA)
• Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Murid betaherpesvirus 1)
• Impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer (2017, NA)
• Pathway linking SSTR2 activation to the prevention of occludin decrease induced by high glucose (2017, NA)
• Working model of metabolic risk factor-induced two-way stimulatory immune checkpoint amplification and systemic/tissue inflammation (2017, Homo sapiens,Mus musculus,Candida dubliniensis)
• Innate immunity (2017, Homo sapiens,Mus musculus,Candida dubliniensis)
• Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer (2017, Homo sapiens,Mus musculus)
• cAMP-phosphoinositide 3-kinase (PI3K)–extracellular signal-regulated protein kinases 1/2 (ERK1/2) pathway activated by the adenosine A2B receptor is important to dendritic cell inhibition and lesion development in mice infected by L (2017, Leishmania amazonensis,Homo sapiens)
• Angiotensin II signaling pathway underlying vascular aging (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Protoporphyrin IX biosynthetic pathway in the shell gland of brown egg laying hens (2017, NA)
• Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factorKB signaling pathway and myoblast-derived tumor necrosis factorA (2017, NA)
• Dkk3 gene encodes a vital intracellular regulator of cell proliferation (2017, Lareunionomyces loeiensis,Eucalyptus intertexta,Derris trifoliata,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Danio rerio,NA)
• Proposed mechanism by which 5‐HT/catecholamine signaling facilitates the membrane trafficking of N‐glycan (2017, Mus musculus,Cavia porcellus,Homo sapiens,Bos taurus,Nicotiana tabacum)
• Interleukin (IL)‐13RA1 in myocardial metabolism (2017, NA)
• miR-155-5p and miR-200a-3p greatly influence TLR4 signaling pathways (2017, NA)
• Path diagram of the nuclear factor kappa B (NFKB) signalling pathway (2017, NA)
• Kinomic profiling of IgA1-secreting cells from healthy control subjects (HC) and IgA nephropathy (IgAN) patients stimulated with interleukin-6 (IL-6) with or without the AZD1480 inhibitor (2017, NA)
• Representative gene networks that were significantly regulated (P < 0.05 with the Fisher's exact test) in response to cocaine in WT compared to SERT Met172 mice (2017, Mus musculus,Homo sapiens)
• The positive feedback regulation between transglutaminase 2 (TGM2) and TLR4 signaling in hepatic stellate cells (HSCs) activation and liver fibrosis (2017, Schistosoma japonicum,Bos taurus,Oryctolagus cuniculus,Schistosoma mansoni,Homo sapiens,Mus musculus,Serinus canaria,NA)
• Schematic model for mechanism involved in ABeta-induced neuronal apoptosis (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Armoracia rusticana,Glycine max,Homo sapiens,Mus musculus,Phenes raptor)
• Epithelial-to-mesenchymal transition in the development of endometriosis (2017, Homo sapiens,Mus musculus)
• HABP2 p.G534E variant in patients with family history of thyroid and breast cancer (2017, NA)
• Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer (2017, NA)
• Subset of microRNAs defining the side population of a human malignant mesothelioma cell line (2017, NA)
• Naoling decoction restores cognitive function by inhibiting the neuroinflammatory network in a rat model of Alzheimer’s disease (2017, Armoracia rusticana,Candida dubliniensis,herbal medicine,Fallopia multiflora,Polygala tenuifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Opsanus beta)
• Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9 (2017, Actinidia chinensis,Homo sapiens)
• Enriched PI3K/AKT signaling pathway, identified by Ingenuity Pathway Analysis based on 300 differentially expressed genes (nominal P values < 0.05) detected exclusively in both week 8 and week 12 topiramate (TPM) groups (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Possible molecular pathways of cisplatin, oxaliplatin and paclitaxel on oxidative stress-dependent TRPA1 and TRPV4 activation in the DRG neurons (2017, NA)
• Principal pathways of cell death (2017, Homo sapiens,Mus musculus)
• STAT3/S1P/S1PR1/SPHK1/SPL-positive feed-forward loop promoting CAC (2017, NA)
• The lithium targeted cellular and molecular mechanism by activating several neurotrophic and associated signaling in Alzheimer’s disease (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Pekania pennanti,Mus musculus,Rattus norvegicus,Homo sapiens)
• OA-induced growth inhibition of colon cancer via reprogramming fatty acid metabolism under hypoxia (2017, Scutellaria baicalensis,Cephalosporium caerulens,Homo sapiens,Mus musculus)
• UCNPs-Ce6-mediated PDT and the mechanism of autophagy.Notes: UCNPs-Ce6-mediated PDT exhibits an autophagic response through the PI3K/Akt/mTOR signaling pathway that is regulated by ROS, which causes the ABCA1-dependent cholesterol efflux (2017, NA)
• mTORC1 controls cell growth and is regulated by the lncRNA-encoded polypeptide SPAR (2017, NA)
• Schematic diagram of G0/G1 phase arrest and ROS-dependent MAPKs pathway in which furanodienone induces cell growth inhibition and cell death in CRC cells (2017, Curcuma wenyujin,Acorus tatarinowii,Curcuma phaeocaulis,Scurrula ferruginea,Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• HF targeting autophagy and metabolism in CRC cells (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Inferred Cx32 anti-apoptotic mechanism (2017, Bos taurus,Capra hircus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,clinical samples)
• PI3K/Akt signalling and its activation in cancer (2017, NA)
• Classical and new Wnt/Beta-catenin pathway canonical and non-canonical pathways (2017, NA)
• CD70 turns on NK cells to attack lymphoma (2017, NA)
• Schematic depiction of reported effects of mammalian caspases in autophagy-related effectors (2017, NA)
• The functions of miR-26a/b-Jagged/Notch axis in modulation of EMT and fibrosis (2017, NA)
• Regulatory role of ubiquitin on RIP1 and RIP3-dependent cell death (2017, Homo sapiens)
• Network of canonical signaling pathways that are individually associated with CpG-ODN responsiveness, host gene coexpression modules, and microbial community features (2017, NA)
• Anti-metastatic effect of PAM (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Glycolysis, tricarboxylic acid (TCA) cycle and oxidative phosphorylation, fatty acid oxidation, pentose phosphate pathway, ornithine cycle, and glutamine metabolism (2017, NA)
• redGEM: Systematic reduction and analysis of genome-scale metabolic reconstructions for development of consistent core metabolic models (2017, NA)
• lumpGEM: Systematic generation of subnetworks and elementally balanced lumped reactions for the biosynthesis of target metabolites (2017, Saccharomyces cerevisiae,Escherichia coli,Zea mays,Diaporthe sclerotioides,Corynebacterium glutamicum,Escherichia coli str. K-12 substr. MG1655,Homo sapiens,Mus musculus)
• Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram positive bacteria (2017, NA)
• Role of SOCS proteins in the regulation of the signaling pathways induced by recognition of gram-negative bacteria (2017, NA)
• Regulatory mechanisms of WBP2 in breast cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Middle East respiratory syndrome-related coronavirus,Fusarium verticillioides)
• Differently expressed protein-coding genes and lncRNAs participating in the AMPK signaling pathway via DAVID KEGG analysis (2017, NA)
• Figure illustrating cumulative flux index in glycolysis, TCA cycle and electron transport chain in glucose metabolic pathway (2017, NA)
• EGFR signalling pathway (2017, Diaporthe sclerotioides,Helianthus annuus,Raphanus sativus,Homo sapiens,Rattus norvegicus,Equus caballus,Leptospira kmetyi,Lavinia exilicauda,Ensis minor,NA)
• Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis? (2017, NA)
• GHK on pulmonary fibrosis (2017, NA)
• Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder (2017, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Schizosaccharomyces pombe,Citrus medica,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Heterogeneity of p53 dependent genomic responses following ethanol exposure in a developmental mouse model of fetal alcohol spectrum disorder (2017, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Schizosaccharomyces pombe,Citrus medica,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells (2017, Homo sapiens,Mus musculus,Bos taurus)
• Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model (2017, NA)
• Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway (2017, NA)
• Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle (2017, NA)
• Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle (2017, NA)
• Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle (2017, NA)
• Characteristic proteins in the plasma of postoperative colorectal and liver cancer patients with Yin deficiency of liver-kidney syndrome (2017, NA)
• Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling (2017, NA)
• Virus-induced endoplasmic reticulum (ER) stress and the consequent downregulation of the stimulator of interferon genes (STING) pathway in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) (2017, NA)
• AMPK Activation by ATIC Knockdown (2017, NA)
• Key downstream genes were identified in the PLK1 signaling pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Dipturus trachyderma,Meleagris gallopavo,Homo sapiens,Mus musculus,Armoracia rusticana,clinical samples)
• Genes uniquely modulated in Fam13a−/− mice are involved in carbohydrate, lipid metabolism, and molecular transport network (2017, NA)
• Genes uniquely modulated in Hhip+/− mice are involved in the connective tissue development and function network (2017, NA)
• CO2-responsive elements in the Ptca1 and Ptca2 promoters and the putative CO2signalling pathway (2017, PX clade,Chlorophyta,Nitzschia alba)
• Number of genes involved in the relevant methanogenesis pathways in both RS and DS datasets (2017, Escherichia coli,Vibrio cholerae,Rhodopseudomonas palustris,Methanospirillum hungatei,Smithella propionica,Syntrophobacter wolinii,Bos taurus,metagenome,metagenomes,activated sludge metagenome,Bubalus bubalis,Bos indicus,Homo sapiens,integrons)
• AD immunopathology and mechanisms of action of targeted therapies (2017, NA)
• Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells (2017, NA)
• Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Nicotiana tabacum,Homo sapiens)
• Toll pathway in fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse (2017, Drosophila melanogaster,Saccharomyces cerevisiae,Olea europaea,Curcuma longa,Capsaspora owczarzaki,Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Homo sapiens,Lactiplantibacillus pentosus,NA)
• Posited future direction to elucidate the epigenetic basis of alcohol-cannabinergic pathway associations (2017, NA)
• Molecular Pathways: Mucins and Drug Delivery in Cancer (2017, NA)
• Confirmation of some miRNA and target gene expression and integrative pathway analysis (2017, NA)
• Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target (2017, NA)
• Regulatory functional territory of PLK-1 and their substrates beyond mitosis (2017, NA)
• NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus,Oryctolagus cuniculus)
• Targeting cancer cell integrins using gold nanorods in photothermal therapy inhibits migration through affecting cytoskeletal proteins (2017, NA)
• Transcriptomic analysis of HBCs reveals that the Notch pathway is differentially regulated during activation from dormancy (2017, NA)
• Coordinating reactions in the intestine elicited by LGG in response to S (2017, NA)
• Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption (2017, Bos taurus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Pieris brassicae,Subgroup C,Feline leukemia virus,Homo sapiens,Theobroma cacao)
• The potential signaling pathways used by bufalin to induce apoptosis in SCC-4 human tongue cancer cells (2017, NA)
• Low-dose triptolide and aspirin suppress NFKB survival pathways (2017, Mus musculus,Homo sapiens)
• Involvement of sirtuins in lifespan/healthspan elongation pathways (2017, Homo sapiens,Saccharomyces cerevisiae)
• HOXA11-AS co-expressed genes were significantly overrepresented in the non-small cell lung cancer pathway, revealed by KEGG pathway analysis– (http://www.kegg.jp/kegg/kegg1.html) (2017, NA)
• Putative blue light signaling pathway in M (2017, Monascus purpureus)
• Reconstruction of essential metabolic pathways and functions, based on TraDIS-predicted essential genes in B (2017, NA)
• Human leukocyte antigen (HLA)-I antigen-processing and presentation pathway (2017, Human immunodeficiency virus 1,Human immunodeficiency virus,NA)
• The PDGF signaling pathway (2017, NA)
• Alcohol’s effects on the hypothalamic–pituitary–adrenal (HPA) axis and the stress response (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Nicotiana tabacum)
• Principal effects of chronic alcohol abuse on anabolic and catabolic mechanisms that maintain skeletal muscle mass (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Simian immunodeficiency virus)
• Major and minor ethanol-oxidizing pathways in the liver (2017, NA)
• PTH binds to the 7-transmembrane PTH1R, which is a GPCR (2017, Homo sapiens)
• Mesenchymal stem cells in idiopathic pulmonary fibrosis (2017, NA)
• Comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis (2017, NA)
• Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Paraechinus aethiopicus,Equus asinus x Equus caballus,Homo sapiens,Mus musculus)
• Transcriptomic pathway analysis of urokinase receptor silenced breast cancer cells: a microarray study (2017, Homo sapiens,Mus musculus,Candida dubliniensis,Calloplesiops altivelis,NA)
• Osteopontin production by TM4SF4 signaling drives a positive feedback autocrine loop with the STAT3 pathway to maintain cancer stem cell-like properties in lung cancer cells (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Let-7g suppresses both canonical and non-canonical NFKB pathways in macrophages leading to anti-atherosclerosis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Diaporthe sclerotioides)
• Differential network of cancer pathway between BRCA tumor samples and controls (2017, NA)
• FGMD: A novel approach for functional gene module detection in cancer (2017, Homo sapiens,Venustaconcha ellipsiformis)
• Schematic overview of p90RSK-mediated regulation of UBR5-containing miRISC (2017, NA)
• The role of BMP4 in regulating hyperandrogenism development (2017, NA)
• The downstream signaling cascade initiated by a hypoxic microenvironment (2017, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Morchella esculenta,Homo sapiens)
• BMP-2 induced EMT and breast cancer stemness through Rb and CD44 signaling (2017, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Cardiac hypertrophy (a) and cardiac fibrosis (b) signaling pathways (2017, NA)
• FGMD: A novel approach for functional gene module detection in cancer (2017, Homo sapiens,Venustaconcha ellipsiformis)
• Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• The mechanism and magnificent background involved in this study (2017, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Saccharomyces cerevisiae)
• Mediation by Menin of milk protein synthesis through the PI3K/Akt/mTOR signaling pathway in mammary epithelial cells (2017, NA)
• Mechanisms underlying crosstalk between Wnt/Beta-catenin signaling and insulin signaling via Irs1 during hepatocarcinogenesis (2017, NA)
• Cellular metabolism in replicating INS 832/13 (2017, NA)
• Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum (2017, NA)
• Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model (2017, Homo sapiens,Mus musculus,Xenopus laevis)
• Angiogenesis during pregnancy: all routes lead to MAPKs (2017, NA)
• Phosphatidylinositol 4,5‐bisphosphate (PIP2) modulates afterhyperpolarizations in oxytocin neurons of the supraoptic nucleus (2017, NA)
• Unraveling Core Functional Microbiota in Traditional Solid-State Fermentation by High-Throughput Amplicons and Metatranscriptomics Sequencing (2017, NA)
• Protein-protein interaction networks of lipid metabolism related pathway enriched genes (2017, NA)
• Protein-protein interaction networks of metabolism related pathway enriched genes (2017, NA)
• Statistically differentially expressed genes (2017, NA)
• Cav1.2 and Cav1.3 signaling mechanisms (2017, NA)
• Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival (2017, Homo sapiens,Mus musculus,Nicotiana tabacum,Major minor)
• Effects of vascular disease treatment on pMV release (2017, NA)
• Mechanism of regulatory T cell (Treg) suppression (2017, Homo sapiens,Mus musculus)
• Working hypothesis of uridine nucleotide signaling in human EC cells lining the GI mucosa (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Cavia porcellus,Equus asinus,Homo sapiens,Diaporthe sclerotioides,Lithobates catesbeianus)
• Bipartite metabolism of IBPs aiming to avoid the exclusive use of glucose (an indispensable carbon source of their mammalian host cells) by the IBPs for their intracellular metabolism (2017, NA)
• To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection (2017, NA)
• Quiescent (A) and activated (B) metabolism in differentiated mammalian cells (2017, NA)
• Schematic presentation of the basic catabolic and anabolic processes of a typical heterotrophic prokaryotic cell: glycolytic pathway (GL), pentose-phosphate pathway (PPP) with its oxidative and non-oxidative arms, and tricarboxylic acid cycle (TCA) (2017, NA)
• Gravity-regulated cellular processes (2017, Homo sapiens,Mus musculus,Bos taurus,Human alphaherpesvirus 3,Calloplesiops altivelis,Sclerobelemnon theseus)
• TLR7/TLR9 and B cell receptor (BCR) ligands incite B cell signaling cascades (2017, Homo sapiens,Mus musculus)
• Hypothetical model for the role of ASXL1 in cell cycle progression through the cooperation with AKT1 and EZH2 (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Escherichia coli,Escherichia coli 27A,Homo sapiens,Mus musculus,Drosophila melanogaster,vectors)
• Targeting the ALK signaling pathway (2017, NA)
• BRAF mutations in the context of mitogen‐activated protein kinase (MAPK) molecular alterations (2017, NA)
• Schematic overview of the MAPK signaling pathway (2017, NA)
• Insulin pathway (2017, Mus musculus,Rattus norvegicus,Ictidomys tridecemlineatus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Gallus gallus,synthetic RNA,NA)
• Signaling mechanism by which kallistatin inhibits EndMT by preventing the TGF-Beta-induced miR-21-Akt-NFKB pathway and oxidative stress and stimulating eNOS/SIRT1 expression in endothelial cells (2017, NA)
• T cell signaling, activation and antigen recognition (2017, NA)
• Schematic model showing AA sensing signaling pathways that might modulate neuronal activity of central olfactory areas (2017, NA)
• Schematic model showing glucose sensing signaling pathways that might modulate neuronal activity of central olfactory areas (2017, NA)
• Number of genes including those downstream of HIF-1 signaling pathway were up-regulated in the pancreas in response to HFD (2017, NA)
• Functions of experimentally verified target genes of miR-17-92 were analyzed by GeneMANIA using genetic interactions, pathway, and physical interaction parameters (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,vectors,synthetic construct,Homo sapiens,Mus musculus,Molva molva)
• Negative control of the HGF/c-MET pathway by TGFB: a new look at the regulation of stemness in glioblastoma (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana)
• Hematopoietic Stem Cell Gene Therapy –Progress and Lessons Learned (2017, NA)
• Modeled mechanism by which FSH via PKA inhibits MKP3/DUSP6 to promote the accumulation of phosphorylated ERK in preantral GCs (2017, NA)
• Targeting phospholipase D in cancer, infection and neurodegenerative disorders (2017, NA)
• IL-6/soluble IL-6 receptor signaling at the nexus of endocrine function: illustrative examples (2017, NA)
• Signaling pathways assigned to the Ingenuity Pathway Analysis (IPA) category “molecular mechanisms of cancer” that have been linked to ovarian cancer and targeted by epigallocatechin‐3‐gallate (EGCG) (2017, Sequoia sempervirens,Camellia sinensis,Homo sapiens)
• Transforming growth factor B activated kinase 1: a potential therapeutic target for rheumatic diseases (2017, NA)
• Illustration of the mechanism linking activation of the nicotinic acetylcholine receptor (nAChR) to altered Ca2+-calmodulin activated signal transduction (MIE, KE1, KE2, and KE3 from ) (2017, Apis mellifera)
• m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway (2017, NA)
• Reactions involving ROS, antioxidant systems and energy metabolism (2017, Homo sapiens)
• Circadian metabolites have pleiotropic mechanisms by which to maintain cellular rhythmicity (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Corticotropin-releasing hormone (CRH) controls the placental “surveillance and response” system so that the fetus can detect threats to survival and adjust its developmental trajectory (2017, Homo sapiens,Pan troglodytes,Gorilla gorilla,Mus musculus,Rattus norvegicus,Alocasia macrorrhizos)
• Metabolic pathways of Staphylococcus aureus glucose and galactose catabolism (2017, Staphylococcus aureus,Homo sapiens)
• Therapeutic targets that regulate YAP/Hippo activity in mesothelioma (2017, NA)
• The proposed signaling mechanisms involved in HNE-induced TF decryption (2017, NA)
• Roles of long noncoding RNAs in colorectal cancer metastasis (2017, NA)
• Roles of long noncoding RNAs in colorectal cancer metastasis (2017, NA)
• Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia (2017, Homo sapiens,Mus musculus)
• Research and therapeutics—traditional and emerging therapies in systemic lupus erythematosus (2017, NA)
• Diagram of major TLR pathways (2017, Paracentrotus lividus,Deuterostomia,Homo sapiens)
• HIF‐1A strongly associates with differentially expressed genes in rAAA (2017, NA)
• Methylation cycle pathway: (A) Methionine and homocysteine (Hcys) are generated by the following enzymes: CBS = cystathionine Beta-synthase, MAT = methionine adenosyltransferase, MS = methionine synthase, SAHH = S-adenosylhomocysteine hydrolasa (2017, NA)
• mTORC1 and mTORC2 as regulators of cell metabolism in immunity (2017, NA)
• Schematic EGFR signaling pathway (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Rescuing the BMPRII signaling pathway in pulmonary arterial hypertension (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Adeno-associated virus)
• mRNA expression of enzymes and factors involved in glycometabolism (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Metabolic profiling of intracellular glycometabolism (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Interaction network of cancer cells and their microenvironment associated with the EMT process (2017, Homo sapiens,clinical samples)
• Scheme depicting mechanisms of resistance observed to BRAF and MEK1/2 inhibitors in vitro and in vivo (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Subgroup A)
• Endocytic Regulation of TGFB/BMP SignalingActivation of TGFB family receptors by ligand binding (i) leads to formation of receptor oligomers, receptor phosphorylation, and internalization (ii) (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Matthiola incana,Equus asinus,Homo sapiens,NA)
• The highlighted metabolic alterations in leiomyomas of the FH and MED12 subtypes (2017, Zea mays,Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion (2017, Human endogenous retrovirus,Homo sapiens)
• Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection (2017, NA)
• Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection (2017, NA)
• Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection (2017, NA)
• Effect of praziquantel on the differential expression of mouse hepatic genes and parasite ATP binding cassette transporter gene family members during Schistosoma mansoni infection (2017, NA)
• Sketch of Hedgehog (Hh) signaling pathway (2017, Scutellaria barbata,Oldenlandia diffusa,Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• Differences in pathway activation between left-sided vs right-sided CRC (2017, Homo sapiens,Armoracia rusticana)
• Angiotensin-(1-7) and the Regulation of Anti-Fibrotic Signaling Pathways (2017, NA)
• Summary of the main findings (2017, NA)
• Pathway signalling starts with the binding of insulin or growth factors to insulin receptors (2017, Homo sapiens,Mus musculus)
• Complex and context dependent functions of the Slit/Robo signaling in angiogenesis (2017, NA)
• Schematic depiction of the strategy employed for mining the O-Man glycoproteome in cell lines with knock-out of COSMC, POMGNT1, POMT1, and POMT2 (2017, NA)
• Wnt signaling pathways (2017, NA)
• Lysine acetylation events involved in carbon fixation (A), tricarboxylic acid cycle (B), and photosynthetic pathway (C) (2017, Synechococcus sp. PCC 7002)
• Asiatic acid (AA)-mediated Nrf2 signaling pathway protects lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced fulminant hepatic failure (FHF) via inhibition of oxidative stress and inflammatory responses (2017, NA)
• Summary diagram of the novel role of Znf179 in glioblastoma multiforme (GBM) cell cycle regulation and differentiation (2017, NA)
• Targeting phospholipase D in cancer, infection and neurodegenerative disorders (2017, NA)
• Nutritional and reproductive signaling revealed by comparative gene expression analysis in Chrysopa pallens (Rambur) at different nutritional statuses (2017, Chrysopa pallens,Homo sapiens)
• Model summarizing regulation of glycolysis and its contribution to photoreceptor physiology (2017, Mus musculus,Homo sapiens)
• Force transmission and mechanotransduction from the extracellular matrix (ECM) to the nucleus (2017, NA)
• Molecular indices of viral disease development in wild migrating salmon (2017, NA)
• Action of lenvatinib and everolimus.Notes: Lenvatinib inhibits RTKs on endothelial cell and cancer cell (2017, Mus musculus,Rattus norvegicus,Homo sapiens,AKT8 retrovirus)
• XREP stress pathway components and relationships (2017, NA)
• The assayed components of the IIS/TOR pathway and their proposed interactions in D (2017, NA)
• Synopsis of intratumoral cholesterol metabolism (2017, Homo sapiens)
• Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity (2017, Mus musculus,Homo sapiens)
• Mechanisms by which 8-pCPT-cGMP improves the outcome of fatty partial liver transplantation (2017, NA)
• (i) Biogenesis and secretion of extracellular vesicles (EVs) such as MVs and exosomes (2017, Homo sapiens,Mus musculus)
• Examples of subnetworks in network reconstructed from injured swine brain treated with VPA (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Sus scrofa)
• The arrest of pollen-tube growth by self-S-RNase in Pyrus pyrifolia (2017, NA)
• Summary of the canonical Th2 pathway and “new spins” on the pathways that lead to allergic inflammation (2017, Cryptococcus neoformans,Alternaria alternata,Gentiana lutea,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Schistosoma mansoni,Nippostrongylus brasiliensis,Helicobacter pylori,gut metagenome)
• Ca2+ regulates different steps of autophagy (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer (2017, NA)
• Signalling by Rho GTPases (upper panel) and Neuronal system pathway (bottom panel) (2017, NA)
• Influence of chosen compounds/proteins on the Wnt signaling pathway which are under consideration as either potential therapeutic targets (continuous line) or potential therapeutic/adjuvant agents (dotted line) (2017, Glycine max,Lareunionomyces loeiensis,Silybum marianum,Mus musculus,Rattus norvegicus,Homo sapiens,Equus asinus x Equus caballus)
• mTOR is the essential signaling pathway for nutrient sensing and apoptosis protection in the B cell (2017, NA)
• The roles of microRNA families in hepatic fibrosis (2017, NA)
• 2-hydroxyisobutyrylated enzymes involved in TCA cycle, pentose phosphate pathway, pyruvate metabolism, glycolysis/gluconeogenesis and starch biosynthesis pathways (2017, Oryza sativa,Homo sapiens)
• Central metabolic pathways of E (2017, Escherichia coli)
• Mechanisms on EET-mediated signaling in response to cardiac hypertrophy and fibrosis (2017, Mus musculus,Homo sapiens)
• Predicted interactions among proteins encoded by genes expressed differentially in late proestrus (2017, NA)
• MiRNA discovery (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Differences and commonalities in TLR4- and FcERI-activated production of proinflammatory cytokines (2017, Oryctolagus cuniculus,Capra hircus,Listeria monocytogenes,Salmonella enterica subsp. enterica serovar Minnesota,Homo sapiens,Mus musculus,vectors,NA)
• Metabolic interventions predicted by the OptForce algorithm (2017, NA)
• Signaling pathway in sea urchin sperm (2017, Homo sapiens,Mus musculus,Danio rerio,Paracentrotus lividus)
• BRD4 pathway in acute myeloid leukemia (AML) cells (2017, NA)
• Canonical TGFB signaling pathway (2017, NA)
• Discovery of extremely halophilic, methyl-reducing euryarchaea provides insights into the evolutionary origin of methanogenesis (2017, NA)
• Pipeline of cell cycle and MAPK signaling pathway (2017, NA)
• Regulation of the zebra finch RLR pathway (2017, NA)
• SUMO pathway plays a crucial role in IBD: model representation of importance of SUMOylation in intestinal health and disease (2017, NA)
• GH/INS/IGF signaling-dependent metabolic pathways that impact aging in all somatic cells and stem cells (2017, NA)
• Improvement of the reprogramming process and replacement of c-Myc by small molecules and chemical compounds (2017, NA)
• RalA/B effectors (2017, Mus musculus,Rattus norvegicus,Reovirus sp.,Replication competent viruses,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Xenopus laevis)
• Electrochemical oxidation pathway of MPA in the presence of sulfone compounds (2017, Escherichia coli,Staphylococcus aureus,Escherichia coli PA5,Escherichia coli PA2,Salvia sclarea)
• Downstream effectors of Ras pathway including Ral pathway and their biological roles (2017, Mus musculus,Rattus norvegicus,Reovirus sp.,Replication competent viruses,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Xenopus laevis)
• DKK1 regulation of signalling pathways (2017, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• DKK1–CKAP4 axis as a novel molecular target for cancer therapy and future perspectives (2017, NA)
• Molecular networks between genes involved in NB development by the data mining IPA software (2017, Gallus gallus,Triportheus paranensis,Homo sapiens,Mus musculus,Sequoia sempervirens)
• Schematic diagram representing the essential role of Epac/PI3K/Akt for A2B receptor-mediated antifibrotic effects (2017, NA)
• Myristoylation in regulating Fas/Fas ligand pathway during cytotoxic T cells activation: binding of a death ligand to Fas receptor leads to the formation of death-inducing signaling complex (DISC) (2017, Drosophila melanogaster,Human immunodeficiency virus 1,Human immunodeficiency virus,Cryptosporidium parvum,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• N-myristoyltransferase functions during T cell activation (2017, Drosophila melanogaster,Human immunodeficiency virus 1,Human immunodeficiency virus,Cryptosporidium parvum,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Transcriptional changes of genes involved in basic metabolism in Bgt during asexual development on Chancellor (2017, NA)
• Schematic model describing the CD99 peptide-induced signal transduction pathway (2017, NA)
• Ischemic preconditioning modulates ROS to confer protection in liver ischemia and reperfusion (2017, NA)
• DKK1 and CKAP4 signalling axis (2017, NA)
• Intestinal FXR and TGR5 cross-talk in the regulation of GLP-1 secretion, hepatic bile aid synthesis, glucose and lipid metabolism, and insulin and glucose sensitivity (2017, NA)
• Schema of the putative mechanisms by which myostatin may influence the function of bone cells (2017, Mus musculus,Homo sapiens)
• Izb regulation of PTHR signaling cascade in bone (2017, NA)
• TRIMs in the regulation of the immune response (2017, NA)
• Ubiquitin chains and ubiquitin enzymes in the TNF-induced NFKB and apoptosis pathways (2017, NA)
• Ubiquitination in B cell activation (2017, NA)
• Ubiquitin enzymes in the regulation of T cell-mediated autoimmunity (2017, NA)
• Ubiquitin enzymes in the TCR signaling pathway (2017, NA)
• Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD (2017, NA)
• Anti-inflammatory signaling pathways influenced by free zinc (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Neisseria meningitidis,Yersinia pestis,Yersinia pestis 24H,Nicotiana tabacum,Diaporthe sclerotioides,Histoplasma capsulatum,Pneumocystis jirovecii,Mus musculus,Rattus norvegicus,prion,Plasmodium falciparum,unidentified,Plasmodium vivax,Homo sapiens,NA)
• Pro-inflammatory signaling pathway influences by zinc (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Neisseria meningitidis,Yersinia pestis,Yersinia pestis 24H,Nicotiana tabacum,Diaporthe sclerotioides,Histoplasma capsulatum,Pneumocystis jirovecii,Mus musculus,Rattus norvegicus,prion,Plasmodium falciparum,unidentified,Plasmodium vivax,Homo sapiens,NA)
• Activation of Toll-like receptor (TLR) signaling pathways is mediated by a complex array of proteins (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Neisseria meningitidis,Yersinia pestis,Yersinia pestis 24H,Nicotiana tabacum,Diaporthe sclerotioides,Histoplasma capsulatum,Pneumocystis jirovecii,Mus musculus,Rattus norvegicus,prion,Plasmodium falciparum,unidentified,Plasmodium vivax,Homo sapiens,NA)
• Simplified diagram of the lipid metabolism canonical pathway (2017, NA)
• Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Human papillomavirus,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Polyomavirus sp.,Merkel cell polyomavirus,Citrus tristeza virus,Chelydra herpesvirus,Homo sapiens,Mus musculus,Gallus gallus,NA)
• ‘Two endocytic routes and two outputs model’ in the Wnt signalling pathways (2017, NA)
• Schematic overview of TGFB signalling (2017, NA)
• lncRNAs in Wnt/B‐catenin signalling (2017, Homo sapiens)
• WNT and SHH signaling pathways (2017, Homo sapiens)
• Upstream regulators identified by Ingenuity Pathway Analysis, predicted to participate in the regulation of gene expression upon A2B-adrenoceptor activation in A7r5A2B vascular smooth muscle cells (2017, NA)
• The B‐catenin‐dependent Wnt signalling cascade in the ON‐state (2017, Homo sapiens,Mus musculus)
• Levels of crosstalk between the HIF and the NFKB pathways (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Activation pathways for canonical and non-canonical NFKB signalling (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Gene interaction network related to lipid metabolism of DEGs between WC and WRR chickens (2017, Gallus gallus,Oncorhynchus mykiss,Coturnix coturnix,Anas platyrhynchos,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Candida dubliniensis,Mecolaesthus longissimus)
• Schematic summary of the mechanisms by which tick-borne Phlebovirus NSs proteins inhibit the canonical IFN induction and signaling pathways (2017, Influenza A virus,unidentified influenza virus,Encephalomyocarditis virus,Ebola virus sp.,Rift Valley fever virus,Bovine viral diarrhea virus 1,Severe fever with thrombocytopenia syndrome virus,Uukuniemi virus,Heartland virus,Punta Toro virus,Toscana virus,Sandfly fever Sicilian virus,tick-borne encephalitis virus group,Lone Star virus,Malsoor virus,American dog tick phlebovirus,Tick phlebovirus,SFTS virus HB29,Ixodes scapularis,Ixodes ricinus,Amblyomma americanum,Dermacentor variabilis,Bos taurus,Oryctolagus cuniculus,Rangifer tarandus,Armoracia rusticana,Matthiola incana,Homo sapiens,Mus musculus,Escherichia coli BL21,NA,NA,NA)
• Action of thioester-containing proteins (TEPs) in mammals and mosquitoes (2017, Drosophila melanogaster,Caenorhabditis elegans,Plasmodium falciparum,Aedes aegypti,Anopheles gambiae,Plasmodium berghei,Glossina morsitans,Galleria mellonella,Deuterostomia,Heterorhabditis bacteriophora,Escherichia coli,Staphylococcus aureus,Porphyromonas gingivalis,Photorhabdus luminescens,Photorhabdus asymbiotica,Homo sapiens,Mus musculus,Candida albicans,West Nile virus)
• WNT signalling pathways (2017, NA)
• Purinergic signaling in microglia in the pathogenesis of neuropathic pain (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Dual role of cellular prion protein in normal host and Alzheimer’s disease (2017, NA)
• Inhibitors of Wnt signalling (2017, NA)
• Bacterium Helicobacter pylori is a well-studied example of a pathogen manipulating host PAK1 signalling (2017, Helicobacter pylori,Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Vaccinia virus,Human alphaherpesvirus 2,Human alphaherpesvirus 3,Ebola virus sp.,Foot-and-mouth disease virus,Suid alphaherpesvirus 1,Variola virus,Human adenovirus sp.,African swine fever virus,Gallid alphaherpesvirus 2,Echovirus E1,Variola minor virus,Singapore grouper iridovirus,Human mastadenovirus B,Amphotropic murine leukemia virus,Drosophila melanogaster,Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Leishmania donovani,Plasmodium berghei,Cryptosporidium parvum,Leishmania amazonensis,Plasmodium falciparum 3D7,Theileria parva,Theileria annulata,Escherichia coli,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Haemophilus influenzae,Neisseria gonorrhoeae,Candidatus Sodalis pierantonius str. SOPE,Escherichia coli K1,Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344,Bartonella bacilliformis,Mus musculus,Bos taurus,Oryctolagus cuniculus,Sus scrofa,Cricetulus griseus,Cricetus cricetus,Homo sapiens,Chlorocebus aethiops,Gallus gallus,NA)
• JAK‐STAT signaling pathway and Cytokine‐cytokine receptor interaction (2017, NA)
• ER stress and the caspase proteolytic system are important regulators of muscle protein homeostasis (2017, NA)
• Roles of tankyrase‐dependent poly(ADP‐ribosyl)ation (PARylation) in Wnt/B‐catenin signalling (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Cricetulus griseus,Citrus macrophylla,Sorbus aucuparia,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,NA)
• BMP–Notch interaction in intestinal homeostasis and CRC disease subtypes (2017, Homo sapiens,Mus musculus)
• General scheme for non-polar and polar lipid biosynthesis (based on Ref (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis,Nucula nucleus)
• Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks (2017, NA)
• Reciprocal regulation of the mitochondrial dynamics machinery by the mitogen activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathways (2017, NA)
• Role of ROS in VEGF-mediated angiogenesis (2017, NA)
• Paraquat hijacks the pentose phosphate pathway to induce oxidative stress and cell death (2017, NA)
• Cellular glucose and glutamine metabolism (2017, Homo sapiens)
• DNA substrates and protein factors required for S-phase checkpoint activation (2017, NA)
• Representation of cilia-associated molecules that have been implicated in DNA damage responses (DDR) (2017, NA)
• Biogenesis of microRNA (miRNA), extracellular vesicles (EV) and uptake mechanisms (2017, Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,Bacillus anthracis,Homo sapiens,Mus musculus,cellular organisms,Lama glama)
• Subcellular location of genes in the canonical pathway, termed as “Signaling by Rho Family GTPases”, as determined via IPA analysis to compare transcriptomes in the APs of pre- and post-ovulation heifers (2017, Mus musculus,Rattus norvegicus,Danio rerio,Cricetulus griseus,Carassius auratus,Anas platyrhynchos,Homo sapiens,Bos taurus,Caenorhabditis elegans,Lolium multiflorum)
• Regulation and execution of the autophagosomal-lysosomal degradation pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Links between m6A regulation and cancerSchematic representation of m6A pathway components and targets involved in cancer progression (2017, Human immunodeficiency virus 1,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Zika virus,Betapolyomavirus macacae,Rous sarcoma virus,Human adenovirus 2,Avian sarcoma virus,Homo sapiens,Saccharomyces cerevisiae,Arabidopsis thaliana,Macaca mulatta,Eucalyptus intertexta,Pan troglodytes,Gallus gallus,Danio rerio,Mus musculus,Drosophila melanogaster,NA)
• Signaling pathways in innate recognition of fungal pathogens and differentiation of CD4+ T helper cells (2017, Histoplasma capsulatum,Pneumocystis jirovecii,Talaromyces marneffei,Sporothrix schenckii,Homo sapiens,Human immunodeficiency virus)
• Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells (2017, NA)
• Data analysis framework for biomedical big data: Application on mesoderm differentiation of human pluripotent stem cells (2017, NA)
• The extrinsic and intrinsic apoptotic pathways, as well as the inhibitory effect of various IAPs on pro-apoptotic molecules (2017, NA)
• Inhibitors of the FZD/LRP/Wnt signalling cascade (2017, Homo sapiens,Metazoa)
• Possible Wnt pathway‐related therapeutic targets in CLL (2017, NA)
• Simplified overview of mammalian Wnt/B‐catenin and Wnt/PCP pathways (2017, NA)
• MiRNAs involved in the regulation of autophagy-related signaling pathways (2017, NA)
• Thyroid cancer hystotypes and their causative genetic events (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Adiponectin signal transduction implicating a cross talk with the insulin signaling pathway: Insulin and adiponectin interact with their respective receptors, which trigger a cascade of signaling events (2017, Candida dubliniensis,Allium sativum,Zataria multiflora,Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic overview of the autophagic pathway and potential drug target points of the pathway (2017, Homo sapiens,Canis lupus familiaris,Plasmodium falciparum)
• Scheme representing major factors of CWIP and the calcineurin signaling pathway (2017, NA)
• Schematic model for regulation of primordial follicle activation via the PI3K signaling pathway (2017, NA)
• Schematic model for chemotherapy-induced oocyte death via the TAp63 signaling pathway (2017, NA)
• Key miRNAs in the resistance to BC treatment (2017, NA)
• Examples of two pathways of histone modification by polycomb complexes leading to suppression of selected TSG (2017, Homo sapiens)
• The human 42 Kb INK4-ARF (CDKN2A/B) locus (not to scale) and its participation in two pathways controlling cell-cycling and differentiation (2017, Homo sapiens)
• Schematic overview of the melatonin/CRH signaling pathway in hamster Leydig cells (2017, NA)
• Better way to slow AD: Co-activation of the Nrf2-ARE antioxidant system and neurotrophic signaling pathway (2017, NA)
• Neuronal defense systems (2017, NA)
• A scheme showing the association of epithelial polarity and ROS production (2017, NA)
• Therapeutic Wound Healing Targets of miR-21Schematic diagram of miR-21 targets TIMP3 and PTEN (2017, Homo sapiens,Mus musculus)
• Interferon (IFN) type 1 signaling; regulation by methylation (2017, NA)
• Histone modifications regulate gene transcription involving renal fibrosis of diabetic kidney disease (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic model of BRAFV600E signaling-induced epigenetic silencing by H3K27me3 in tumorigenesis (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Graphical representation for Mel regulation in DRG neurons (2017, NA)
• Protective effects of Sestrins in cardiovascular diseases, metabolic disorders, neurodegenerative diseases, and cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• AMPK and mTOR pathway by Sestrins (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• MTOR signaling pathway and the possibility of curcumin's pharmacological action on the pathway in the treatment of SCI (2017, NA)
• Schematic model of miR-200c accelerating hepatic stellate cell-induced liver fibrosis via targeting the FOG2/PI3K pathway (2017, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana,NA)
• Top Left: Gene expression networks activated whilst differentiating cells are treated with varying doses of escitalopram (2017, NA)
• Regulatory network of arginine and proline metabolisms (2017, NA)
• Network representation of the signaling pathway with CatSper channel as the only source of intracellular Ca 2+ concentration (2017, NA)
• Model-II signaling Pathway and Logical Network of the Speract-Activated Signaling Pathway (SASP) (2017, NA)
• Signaling pathways that are key regulators of pluripotency in mESCs (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Cellular 11Beta-hydroxysteroid Dehydrogenase 1 on LPS-induced Inflammatory Responses in Synovial Cell Line, SW982 (2017, Gallus gallus,Oncorhynchus mykiss,Homo sapiens,Rattus norvegicus,Bos taurus,Armoracia rusticana)
• Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy (2017, NA)
• microRNAs in cancer (2017, NA)
• Pathway analysis using WikiPathways revealed that the factors related to the calcium signalling pathway (Kelder, T., Chichester, C., Hanspers, K.: Calcium Regulation in the Cardiac Cell (Danio rerio) (2017, NA)
• Hypoxia/IL-6/lncTCF7/TCF7/Wnt signalling axis in glioma (2017, NA)
• Directing the use of DDR kinase inhibitors in cancer treatment (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Inhibitory nucleotide-binding oligomerization domain (NOD)-like receptors put the brake on NFKB activation via canonical and non-canonical pathways (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Klebsiella pneumoniae,Brucella abortus,Homo sapiens,Mus musculus,Danio rerio,gut metagenome,Vasconcellea candicans)
• Networks of signalling and transcription factors regulate the pheromone response (2017, NA)
• Mechanisms linking folate to cellular function (2017, NA)
• Strategies of effective targeting of hepatocyte growth factor (HGF)/c-Met signaling for the prevention of hepatocellular carcinoma (HCC) (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Molva molva,Ganoderma lucidum)
• Ror2-expression-responsive module (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Danio rerio,Candida dubliniensis)
• Schematic illustrating the role of Nupr1 in METH-induced apoptosis and autophagy in neuronal cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Raphanus sativus,Gorgonidium striatum,Homo sapiens)
• The potential roles of miR-M4-5p and miR-K12-11 in regulating the TGFB signaling pathway and promoting tumorigenesis (2017, Human gammaherpesvirus 4,Human gammaherpesvirus 8,Gallid alphaherpesvirus 2,Avian leukosis virus,Reticuloendotheliosis virus,Meleagrid alphaherpesvirus 1,Gallid alphaherpesvirus 3,Mareks disease virus serotype 2 MDV2,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,NA)
• PACS-2 Akt site and NLS together modulate membrane traffic, TRAIL-induced apoptosis, MAM integrity and the response to DNA damage (2017, NA)
• Protein traffic steps mediated by PACS-1 and PACS-2 (2017, NA)
• Signal transduction by BG (2017, Escherichia coli,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Escherichia coli K-12,Salmonella enterica,Pseudomonas putida,Vibrio cholerae,Haemophilus influenzae,Escherichia coli O157H7,Salmonella enterica subsp. enterica serovar Typhi,Pasteurella multocida,Escherichia coli Nissle 1917,Salmonella enterica subsp. enterica serovar Enteritidis,Brucella suis,Actinobacillus pleuropneumoniae,Edwardsiella tarda,Escherichia coli C,Mannheimia haemolytica,Borrelia anserina,Salmonella enterica subsp. enterica serovar Gallinarum,Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,unidentified influenza virus,H1N1 subtype,Foot-and-mouth disease virus,Influenza B virus BShanghai3612002,Bos taurus,Oryctolagus cuniculus,Sus scrofa,Trichosurus vulpecula,Gallus gallus,Oreochromis mossambicus,Pollachius virens,Bacteriophage sp.,Sinsheimervirus phiX174,Homo sapiens,Mus musculus)
• Immunomodulatory properties of craniofacial MSCs (2017, NA)
• Hippo信号通路。A：果蝇中的Hippo信号通路；B：哺乳动物中的Hippo信号通路。Hippo signaling pathway (2017, NA)
• Canonical and non-canonical NFKB signaling in humans (2017, NA)
• Innate immune receptors drive dengue virus immune activation and disease (2017, Dengue virus)
• Hypoxia signalling pathway in haematological malignancies (2017, NA)
• Involvement of miR-106b in tumorigenic actions of both prolactin and estradiol (2017, Homo sapiens,Rattus norvegicus,Bos taurus)
• Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder (2017, NA)
• Summary diagram of energy metabolism pathway (2017, Eutheria,Panthera leo,Delphinus delphis,Bos grunniens,Tursiops truncatus,Tupaia chinensis,Orcinus orca,Balaena mysticetus,Physeter catodon,Balaenoptera acutorostrata,Trichechus manatus latirostris,Lipotes vexillifer,Myotis brandtii,Trichechus manatus,Odobenus rosmarus divergens,Pantholops hodgsonii,Leptonychotes weddellii,Dugong dugon,Bos mutus,Mus musculus,Rattus norvegicus,Heterocephalus glaber,Cryptomys hottentotus,Homo sapiens,Macaca mulatta,Dipnomorpha,Python bivittatus,Diaporthe sclerotioides)
• Ten differentially expressed genes between human bizarre parosteal osteochondromatous proliferation and osteochondroma enriched in the TGFB signaling pathway (2017, NA)
• Diverse cellular functions of arrestin scaffolds (2017, NA)
• Diagram of KATPHI Beta-cell glucose and amino acid metabolism (2017, Homo sapiens)
• DOT1L safeguards cartilage homeostasis and protects against osteoarthritis (2017, NA)
• Notch signaling (2017, NA)
• Proposed model for persistent fibrosis in mice after lung injury (2017, NA)
• Estrogen biosynthesis (2017, Homo sapiens,Escherichia coli,Oryctolagus cuniculus,Avena sativa)
• Differential roles of 3-Hydroxyflavone and 7-Hydroxyflavone against nicotine-induced oxidative stress (2017, NA)
• Scheme summarizing the signaling pathway through which PKD mediates NFKB activation and the role of PKD in multiple pathological processes associated with pancreatitis (2017, NA)
• Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies (2017, Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• Examples of aripiprazole functional selectivity at the D2r: 1) Aripiprazole partially inhibits the G(A) pathway , 2) acts as an antagonist at the G(BG) pathway , 3) and acts as an agonist by increasing phosphorylation of GSK3 in the PFC (2017, NA)
• The Janus kinase (JAK)- signal transducer and activator of transcription (STAT) pathway (2017, NA)
• Hypothetical regulation of P-gp and Bcrp expressions at the BBB following subchronic exposure to morphine, and presumably implicated signaling pathways (2017, NA)
• Extended regulatory network to describe Nanog multistable dynamics in serum/LIF (2017, Homo sapiens,Mus musculus,unidentified,Lambdavirus lambda,Byasa polyeuctes,NA)
• Iron homeostasis (2017, Homo sapiens,Rattus norvegicus,Helicobacter pylori,Citrullus lanatus subsp. vulgaris,NA)
• CoQ biosynthesis and effect of 4-HB analogs (2017, Mus musculus,Rattus norvegicus,Escherichia coli,Cricetulus griseus,Escherichia coli K-12,Azotobacter vinelandii,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Current model for selective compound families to promote neuronal compensation in HD via a stress response system centered onto FOXO and its co-factors (2017, NA)
• Regulation network of the lectin genes related to immune activities (2017, NA)
• mTORC1 as the main gateway to autophagy (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces cerevisiae CAT-1,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Hepatitis B virus,NA)
• Schematic view of UPR response in mammals (2017, NA)
• Underlying mechanism for the renoprotective effect of salvianolic acid B (SAB) (2017, NA)
• Bisphenol A induces cell cycle arrest in primary and prostate cancer cells through EGFR/ERK/p53 signaling pathway activation (2017, NA)
• Proposed signaling pathway activated by CTS in CCA cells.Notes: The potential mechanism of apoptosis induced by CTS in HCCC-9810 and RBE cells (2017, Salvia miltiorrhiza,Cinnamomum kotoense,Homo sapiens,Mus musculus,Bos taurus)
• Proposed metabolic shift during biofilm induction in B (2017, Bacillus cereus)
• Schematic illustration depicting the potential pathways associated with the anti-inflammatory effects of ESEAF on LPS-stimulated BV-2 microglia cells (2017, Elephantopus scaber,Homo sapiens)
• Mito-xenophagic degradation of bacterial structures in chlamydia-infected DCs (2017, Escherichia coli,Salmonella enterica,Chlamydia trachomatis,Mycobacterium leprae,Chlamydia muridarum,Chlamydia psittaci,Homo sapiens,Mus musculus,Rattus norvegicus,Matthiola incana,Vasconcellea candicans,Chlorocebus aethiops,Drosophila melanogaster)
• Metallothionein roles in aging and reactive oxygen species (2017, Drosophila melanogaster,Caenorhabditis elegans,Metaphire sieboldi,earthworms,Lumbricus rubellus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli)
• Wnt/Beta-catenin signaling pathway (2017, NA)
• Stabilization of Sur8 via PKCA/D degradation promotes transformation and migration of colorectal cancer cells (2017, Homo sapiens,Mus musculus,Escherichia coli,Cerobasis alpha)
• Identification of hub genes related to silicone-induced immune response in rats (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• MEK/ERK addiction in CNL/aCML (2017, Homo sapiens,Mus musculus)
• Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway (2017, Adenoviridae,Mouse mammary tumor virus,Homo sapiens,Mus musculus,Bos taurus)
• Chondroitin sulfatases differentially regulate Wnt signaling in prostate stem cells through effects on SHP2, phospho-ERK1/2, and Dickkopf Wnt signaling pathway inhibitor (DKK3) (2017, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Siproeta stelenes)
• SIRT6 histone deacetylase functions as a potential oncogene in human melanoma (2017, NA)
• BMP4 signaling pathways (2017, NA)
• Intrinsic apoptosis pathway (2017, NA)
• Extrinsic apoptosis pathway (2017, NA)
• Mechanisms of cytokine-induced dysfunction and death of insulin-secreting cells mediated by intracellular S1P (2017, NA)
• Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes (2017, Saccharomyces cerevisiae,Matthiola incana,Citrus macrophylla,Homo sapiens)
• Secreted T (2017, NA)
• Integrated Transcriptomic and Metabolomic Analysis of Five Panax ginseng Cultivars Reveals the Dynamics of Ginsenoside Biosynthesis (2017, Panax ginseng)
• FGFR signaling pathway (2017, NA)
• Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3B Signaling Pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Phagocytosis mediated by receptors (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Human immunodeficiency virus 1,prion)
• Nodes linking the enriched KEGG pathway by hub genes (2017, NA)
• Network pathway: pathway enrichment analysis was performed (2017, herbal medicine,Agaricus bisporus,Astragalus membranaceus,Citrus reticulata,Zanthoxylum armatum,Caulophyllum thalictroides,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Cerobasis alpha)
• Histone Deacetylase Inhibitors Interrupt HSP90•RASGRP1 and HSP90•CRAF Interactions to Upregulate BIM and Circumvent Drug Resistance in Lymphoma Cells (2017, Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Bikinia letestui,Homo sapiens,Mus musculus)
• General induction and receptor signaling pathways of type I and type III IFNs (2017, NA)
• TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion (2017, Homo sapiens,Mus musculus,Bos taurus,unidentified influenza virus,Sequoia sempervirens)
• TNFAlpha-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion (2017, Homo sapiens,Mus musculus,Bos taurus,unidentified influenza virus,Sequoia sempervirens)
• The glucocorticoid receptor and nitric oxide signaling pathways (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Network of organismal abnormalities and cancer (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Gallus gallus)
• Schematic Overview of the Norrin-Beta-Catenin PathwayMutations in the genes encoding the ligand Norrin, the receptors FZD4, LRP5, and TSPAN12, and now the transcriptional activator Beta-catenin all cause FEVR (2017, NA)
• Working model of enhanced phrenic pLTF in end-stage SOD1G93A rats (2017, Homo sapiens,Rattus norvegicus)
• Adding Asp, Glu and Met on the metabolic pathway of A (2017, NA)
• Anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites (2017, NA)
• DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity (2017, NA)
• Kv7 in regulating the contractile state of smooth muscle (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Oryctolagus cuniculus,Xenopus laevis,Mustela lutreola,Lithobates catesbeianus,Homo sapiens)
• Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer (2017, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Curcuma zedoaria,Homo sapiens,Mus musculus)
• FKBP11 affects the formation and progression of AAD (2017, NA)
• Seasonal shifts in accumulation of glycerol biosynthetic gene transcripts in mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae), larvae (2017, NA)
• Two HEB-dependent pathways of GDT17 cell development (2017, NA)
• Insulin resistance in LMC metabolism, inflammation, and contractility (2017, NA)
• Regulatory network model of DNA replication coupled with nicotinamide (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Homo sapiens)
• Interaction network model (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Homo sapiens)
• BMP2 or BMP6 signaling enhances adipocyte function (2017, Homo sapiens,Mus musculus,Bos taurus)
• Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse (2017, Homo sapiens,Mus musculus,Danio rerio)
• Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NFKB activity (2017, NA)
• DE genes are significantly overrepresented in the Toll-like receptor signaling pathway (2017, Homo sapiens,Mus musculus)
• Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis (2017, Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus)
• Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List (2017, Homo sapiens,Mus musculus)
• Proposed IL-6 Transsignaling Pathway and Proposed Impact of JAK1V310I Mutation (2017, NA)
• Signaling pathways in self-renewal and differentiation of in vitro pluripotent stem cell populations (2017, Homo sapiens,Mus musculus,Diaporthe sclerotioides,unidentified)
• Tumor exome sequencing and copy number alterations reveal potential predictors of intrinsic resistance to multi-targeted tyrosine kinase inhibitors (2017, NA)
• Interconnected processes of (i) S1P synthesis and degradation within the sphingomyelin/salvage pathway, (ii) S1P export and (iii) signaling through binding to five specific G-protein-coupled receptors, S1PR1-5 (2017, NA)
• Soluble PD-1 and PD-L1: predictive and prognostic significance in cancer (2017, NA)
• CYP19A1 polymorphisms associated with coronary artery disease and circulating sex hormone levels in a Chinese population (2017, NA)
• Protective or pathogenic roles of innate lymphoid cells (ILCs) in liver diseases (2017, NA)
• GRN and SBN circuits (2017, NA)
• Summary of signaling events and downstream transcription factors driving specification of the blood stem cell lineage (2017, NA)
• ABA signaling in human granulocytes (2017, NA)
• MTOR-associated BRN: abstraction of mTOR signaling pathway (Figure ) in BRN (2017, NA)
• mTOR Signaling Pathway (2017, NA)
• Proposed model for the HGH solution-induced HPMC death (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Cerobasis alpha)
• Viral RNA detection by RLRs and TLRs, signaling pathways and overview of FMDV strategies aimed at its supression (2017, unidentified influenza virus,Japanese encephalitis virus,Coxsackievirus B3,Enterovirus A71,Encephalomyocarditis virus,Coxsackievirus,Murine hepatitis virus,Foot-and-mouth disease virus,Hepatovirus A,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,synthetic RNA,NA,NA)
• ARF/p53 pathway (2017, NA)
• Estrogen signaling pathway (2017, NA)
• Network analysis obtained from IPA of differentially regulated proteins (p ≤ 0.05) between recurrence (R) and recurrence-free (RF) patients (2017, NA)
• Major intracellular pathways leading to Type-I-IFN production (2017, NA)
• Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer (2017, Homo sapiens,Bos taurus,clinical samples)
• Genes associated to tumorigenesis and/or cancer progression found differentially methylated in HA22T/VGH sorafenib treated cells (2017, Homo sapiens,Bos taurus)
• Pathway of AD enriched in target DEGs of DEmiRNAs of AD (2017, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• Pathway of Huntington’s disease enriched in target DEGs of DEmiRNAs of AD (2017, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• Protein–protein interaction networks of differentially expressed proteins (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Crassostrea gigas)
• Targeting the SUMO pathway as a novel treatment for anaplastic thyroid cancer (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana)
• Hypothetical schematic connecting basal IP3R mediated Ca2+ release to protein translation, via AMPK and the TOR signalling pathway (2017, NA)
• Working hypothesis regarding the mechanism by which SDF‐1A (stromal cell‐derived factor 1A) stimulates cell proliferation (2017, NA)
• Lipopolysaccharide induces apoptosis of hepatocytes via the TLR4/PI3K/Akt/GSK-3B pathway (2017, Armoracia rusticana,Allium cepa,Sophora flavescens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Working model portraying the effects of WNT/Beta-catenin signaling in PTENWT melanoma cells under nutrient starvation conditions (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Lareunionomyces loeiensis,Vasconcellea candicans,Homo sapiens,Danio rerio,Mouse mammary tumor virus)
• Major Anti-tumorigenic pharmacological properties of thymoquinone (2017, NA)
• Proposed mechanism(s) underlying the improvement of endothelium‐dependent vasodilation after Roux‐en‐Y gastric bypass (RYGB) (2017, NA)
• Illustration of a proposed signaling pathway of innate and adaptive immune activation in the Nx model (A) (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Crosstalk of hypoxia-induced endothelial-mesenchymal transition (EndMT) signaling pathways (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Regulatory network elicited by nuclear translocation of syndecan-1 leading to inhibition of proliferation and survival (2017, NA)
• Upstream regulators and downstream biological effects predicted by Ingenuity Pathway Analysis on the proteome level (2017, NA)
• Targeting to bile acid and lipid metabolism in NASH treatment (2017, Homo sapiens,Mus musculus,gut metagenome,Adeno-associated virus)
• Model summarising metabolic changes in sentitive versus resistant melanoma cells upon BRAF inhibition (2017, NA)
• ATP-binding cassette transporter A1 regulates phosphoantigen release and VG9VD2 T cell activation by dendritic cells (2017, NA)
• Schematic outline of intracellular Ras signaling pathways in the suprachiasmatic nucleus (SCN) regulating circadian clockwork (2017, NA)
• Crosstalk between leptin signaling, cancer stem cells, histone deacetylases and microRNA (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Mechanism of the PM-induced inflammatory response in the lungs (schematic) (2017, Homo sapiens,Mus musculus)
• MOA of CHST15/CS-E and STNM01 in tissue remodeling in IBD (2017, Homo sapiens)
• Regulation of Beta-catenin activity and function in cancer: therapeutic opportunities (2017, NA)
• Combinatorial treatment with polyI:C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway (2017, Armoracia rusticana,Agaricus bisporus,Citrus limon,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Meleagris gallopavo)
• Wnt and Hippo signaling network that either promotes or inhibits Wnt signaling through cytoplasmic and nuclear interactions of the two pathways (2017, NA)
• T-type calcium channels in spontaneous myogenic tone development in the rat middle cerebral artery and mouse small mesenteric artery, as explained in the text (2017, NA)
• PI3K/Akt/mTOR signaling pathway and relevant PI3K inhibitors (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Clinitrachus argentatus)
• Proposed model showing the mechanism of action of PPARG agonists (TRG and RSG) on TGFB1-induced fibrogenic activation in human primary intestinal myofibroblasts (2017, NA)
• Microglial M1 and M2 signaling in neurodegeneration, and potential targets for neuroprotection (2017, Homo sapiens,Macaca fascicularis,Papio hamadryas,Mus musculus,Rattus norvegicus,Adeno-associated virus,adeno-associated virus 2,Bos taurus,Caenorhabditis elegans)
• Examples of NOX signal transduction (2017, Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Venustaconcha ellipsiformis,Homo sapiens,Oryctolagus cuniculus)
• Endogenous sources and consequences of ROS overproduction (2017, Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Venustaconcha ellipsiformis,Homo sapiens,Oryctolagus cuniculus)
• Ubiquitination mediates the NF‐KB activation and nuclear translocation (2017, NA)
• Snapshot of some of the transcriptome changes in S (2017, NA)
• Location of BHP biosynthetic genes and gene clusters in the genomes of SD1, SD3, and SD4 Acidobacteria and a number of selected environmental genomes as determined by BLAST protein searches (2017, Zymomonas mobilis,Methylorubrum extorquens,Bradyrhizobium japonicum,Chlorobium limicola,Acetobacter pasteurianus,Moorena producens,Methylobacterium nodulans,Edaphobacter aggregans,Thermoanaerobaculum aquaticum,Blastococcus saxobsidens,Terracidiphilus gabretensis,Candidatus Solibacter usitatus Ellin6076,Edaphobacter modestus,Candidatus Koribacter versatilis,Paraburkholderia sartisoli,Acidobacteriaceae bacterium A2-4c,Blastocatella fastidiosa,Acidobacteriaceae bacterium KBS 83,Telmatobacter sp. 15-28,Telmatobacter sp. 15-8A,Bryobacter aggregatus MPL3,Acidobacteriaceae bacterium URHE0068,Aridibacter famidurans,Aridibacter kavangonensis,Brevitalea aridisoli,Stenotrophobacter terrae,Paludibaculum fermentans,Vicinamibacter silvestris,Luteitalea pratensis,Terriglobus sp. TAA 43,Bryobacter aggregatus,Terriglobus saanensis SP1PR4,Pyrinomonas methylaliphatogenes,Granulicella aggregans,Granulicella paludicola,Acidobacteriaceae bacterium KBS 146,Granulicella mallensis MP5ACTX8,Embryophyta,Erebia epipsodea,Phytomonas oxycareni,Begonia deliciosa,Triportheus paranensis,environmental samples,Homo sapiens)
• Illustration of mechanistic action of quercetin in L6 myotubes (2017, NA)
• Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Cerobasis alpha)
• Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway (2017, Ogataea polymorpha,Homo sapiens)
• Ingenuity Pathway Analysis showing a network biology system for the interaction between both the miRNAs and the metabolites identified from the metabonomic analysis (2017, H10N3 subtype,H11N2 subtype,H12N5 subtype,H11N4 subtype,H8N3 subtype,H5N4 subtype,Mus musculus,Cavia porcellus,Homo sapiens)
• Working model of Beta-Lap in acute pancreatitis (2017, NA)
• YAP protein interaction, activation, and inactivation within the canonical Hippo Pathway (2017, Homo sapiens)
• Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue (2017, NA)
• A, The GI-FKF1-CDF1 module during flowering in Arabidopsis (2017, NA)
• Exploration of chorismate and isochorismate metabolism (2017, NA)
• Conserved ABA signaling pathway in epidermis of H (2017, NA)
• Sub-network of cell cycle pathway regulated by C1orf132 and TMPO-AS1 (2017, NA)
• Congression via DCP and integration with checkpoint signaling (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Euphilotes enoptes)
• Transcriptomic dissection reveals wide spread differential expression in chickpea during early time points of Fusarium oxysporum f. sp. ciceri Race 1 attack (2017, NA)
• Transcriptomic dissection reveals wide spread differential expression in chickpea during early time points of Fusarium oxysporum f. sp. ciceri Race 1 attack (2017, NA)
• Preterm birth results in alterations in gluconeogenic gene expression and hepatic insulin signaling impairments (2017, NA)
• Schematic drawing that illustrates the likely signaling pathway by which laminin A2 at the basement membrane regulates Sertoli cell BTB dynamics in the seminiferous epithelium of rat testes (2017, NA)
• Metabolic fates of glucose in mammalian cells (2017, NA)
• Representation of the molecular interaction pathway analysis of the associated and causal genes linked to aneuploidy (2017, Homo sapiens,Mus musculus)
• Network model describing association of hyperactivated mTOR signaling with developmental and morphological defects in forebrains (2017, NA)
• Effect of PKM2 on GC and the related pathways (2017, Homo sapiens,Mus musculus)
• Lipotoxicity-induced NLRP3 inflammasome activation in TEC (2017, NA)
• FLT3 signaling pathway (2017, NA)
• Possible mechanism of BBr for ameliorating the cognitive impairment in DM rats (2017, NA)
• IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mandrillus leucophaeus,Mus musculus)
• Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations (2017, Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Potato spindle tuber viroid)
• Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis (2017, NA)
• Co-expression network of flowering-related genes (2017, NA)
• Signalling pathways associated with PRDXs and hypothetical illustration of PRDXs in mouse spermatozoa (2017, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Armoracia rusticana,Glycine max,Homo sapiens,Mus musculus,Corvus corax)
• ZIKV genome structure and signaling transductions underlying ZIKV infection (2017, Zika virus,Homo sapiens)
• An integrated model for valve development (2017, NA)
• Fucose metabolism pathways and variation in types of fucosylated glycans (2017, Homo sapiens,Mus musculus)
• Targeting HOX/PBX dimers in cancer (2017, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Carboplatin-induced hematotoxicity among patients with non-small cell lung cancer: Analysis on clinical adverse events and drug-gene interactions (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples)
• Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer (2017, NA)
• Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head (2017, NA)
• Increased IL-17 induced by rituximab or irradiation promotes the growth of DLBCL cells (2017, NA)
• Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Cerobasis alpha)
• Insulin resistance in obesity (2017, NA)
• Apoptosis pathway (2017, Fallopia multiflora)
• Précis of signaling pathways involved in glioma and inhibition by mTOR, AKT, PI3K and ERK inhibitors and genetic configuration of TSC1 and TSC2 (2017, Homo sapiens)
• Phosphoproteomic analysis of CCL2 treated DCs and confirmation of relevant signaling pathways (2017, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Ra,Homo sapiens)
• Functional analysis of IRF5 pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Influenza A virus)
• CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NFKB/ iNOS pathway in STZ-induced diabetic mice (2017, NA)
• Elucidation of the compatible interaction between banana and Meloidogyne incognita via high-throughput proteome profiling (2017, Meloidogyne incognita,Homo sapiens)
• Mevalonate metabolism in immune and cancer cells (2017, Candida dubliniensis,Candida albicans,Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG)
• Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature (2017, NA)
• Neuroprotective mechanism of 1T3O (2017, Armoracia rusticana,Toxicodendron vernicifluum,Stemona tuberosa,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Cladiella australis,Homo sapiens,Bos taurus,Danio rerio)
• Proposed action mechanisms of glutamine in intestinal cells (2017, NA)
• TrkA activation promotes anti-inflammatory pathways (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Callithrix jacchus,Oryctolagus cuniculus,Gallus gallus,Clostridium perfringens)
• Intracellular GH signaling (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Schematic presentation of ROS scavenging pathway in chloroplasts (2017, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Triticum aestivum,Spinacia oleracea,Chlamydomonas reinhardtii,Daucus carota,Pisum sativum,Medicago sativa,Gossypium hirsutum,Ipomoea batatas,Beta vulgaris,Brassica rapa subsp. pekinensis,Vigna unguiculata,Brassica rapa subsp. oleifera,Suaeda salsa,Mesembryanthemum crystallinum,Eutrema halophilum,Avicennia marina,Kandelia candel,Salicornia europaea,Puccinellia tenuiflora,Oryza coarctata,Homo sapiens,Synechocystis sp. PCC 6803)
• The regulation of mitochondrial biogenesis (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Oestrogen signalling pathways (2017, NA)
• Mechanism of epithelial-to-mesenchymal transition (EMT) (2017, Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• ‘Eat-me' signals, phagocytic machinery and signaling pathways (2017, Mus musculus,Rattus norvegicus,Candida dubliniensis,Iris germanica,Homo sapiens,Caenorhabditis elegans)
• Microbiota mediates T-cell differentiation in homeostatic or pathogenic conditions (2017, NA)
• Catalase andnucleoside diphosphate kinase (NDPK2) played important regulative roles in mitogen-activated protein kinase (MAPK) signaling cascades pathway (2017, NA)
• Proposed regulatory signaling network for HCV entry (2017, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human papillomavirus type 16,Vaccinia virus,Coxsackievirus,Bovine viral diarrhea virus 1,Non-A non-B hepatitis virus,Homo sapiens,Bos taurus,Sus scrofa,Pan troglodytes,Mus musculus,Diaporthe sclerotioides,Yersinia pestis,NA)
• HBV modulation of innate immune sensors (2017, Hepatitis B virus,Hepatitis delta virus,recombinant Hepatitis B virus,Homo sapiens,Mus musculus,Pan troglodytes,Marmota monax,NA,NA)
• Suppression of BCR signaling is detrimental to growth and sensitizes B-ALL to dex (2017, NA)
• FGF signaling pathway (2017, NA)
• Regulation of autophagy by nutrients and hormones via the mammalian target of rapamycin (mTOR) signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• GLP-1R signalling promotes Beta-cell glucose metabolism via mTOR-dependent HIF-1A activation (2017, NA)
• Both HPV E6 and E7 interfere with p53 function (2017, NA)
• Map of DEGs in Oncopig STS cell lines and their functions within the TP53 signaling pathway (2017, Canis lupus familiaris,Sus scrofa,Homo sapiens,Mus musculus)
• Map of DEGs in Oncopig leiomyosarcomas and their functions within the TP53 signaling pathway (2017, Canis lupus familiaris,Sus scrofa,Homo sapiens,Mus musculus)
• Comparison of the adolescent and adult mouse prefrontal cortex proteome (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Zea mays,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster)
• Comparison of the adolescent and adult mouse prefrontal cortex proteome (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Zea mays,Sequoia sempervirens,Homo sapiens,Drosophila melanogaster)
• A2A adenosine receptors-triggered signal transduction cascade in cancer cells (2017, NA)
• IL-8/IL-8R axis (2017, Homo sapiens)
• Different PPGL molecular subgroups with corresponding driver mutations and a proportion of hereditary disease in the respective cluster (2017, Homo sapiens)
• Operating mode of the E-cadherin-catenin complex in tumor metastasis (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Scheme showed the probably metabolic pathways in patient with PH2 and AGXT2 deficiency (2017, NA)
• DEK promoted EMT and angiogenesis through regulating PI3K/AKT/mTOR pathway in triple-negative breast cancer (2017, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Homo sapiens,Mus musculus,Gallus gallus,Human papillomavirus type 16,clinical samples,Rubus corchorifolius)
• Brain metabolism in health, aging, and neurodegeneration (2017, NA)
• Brain metabolism in health, aging, and neurodegeneration (2017, NA)
• Opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in gliomas (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Oryza sativa)
• Role of WNT/beta-catenin pathway on aerobic glycolysis in gliomas (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Oryza sativa)
• Schematic pathway illustrating the inhibitory effects of BMP4 on PDGF-induced calpain-2 activation, cell proliferation, and collagen synthesis in normal and PAH PASMCs (2017, NA)
• Congenital heart defect BioCore (CHD-BioCore): strategy and frame work (2017, NA)
• Proposed model for the effects of GSK3B inhibitors on HCV virion particles’ assembly/release (2017, NA)
• Molecular mechanisms underlying the neuroprotective effect of IGFBP-6 via IGF-1R-dependent signaling (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Vasconcellea candicans,Homo sapiens)
• A model for transcriptional regulation of RGC differentiation (2017, NA)
• Cartoon of Wnt signaling pathway (2017, Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,unidentified)
• Schematic presentation of the regulation of metabolic signaling and lysosomal movement by the lysosome-associated Ragulator complex that consists of five LAMTOR subunits (LT1–5) (2017, NA)
• Key enzymes in the glycolytic, pentose phosphate, pyruvate, and UDP-N-acetyl-galactosamine pathways are upregulated in the in vivo Giardia foci (2017, NA)
• Sugarcane responses to S (2017, Arabidopsis thaliana,Nicotiana tabacum,Zea mays,Solanum lycopersicum,Embryophyta,Saccharum officinarum,Fusarium verticillioides,Fusarium fujikuroi,Sporisorium scitamineum,Venustaconcha ellipsiformis,Helicoverpa zea,Pseudomonas chlororaphis O6)
• Signaling pathways of TLRs include MYD-88 independent and MYD-88 dependent pathways (2017, NA)
• Neuroimmune interface and the role of glia in the pain response (2017, NA)
• Innate immunity signaling pathways by bacterial pathogens (2017, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Clostridioides difficile,Bacillus anthracis,Shigella flexneri,Chlamydia trachomatis,Clostridium perfringens,Francisella tularensis,Legionella pneumophila,Streptococcus sp. group A,Brucella abortus,Yersinia pestis,Coxiella burnetii,Anaplasma phagocytophilum,Brucella melitensis,Legionella pneumophila str. Paris,Simkania negevensis,Pseudomonas aeruginosa CIG1,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Human T-cell leukemia virus type I)
• ROCK-activated vitreoretinal diseases (2017, NA)
• Schematic depiction of uPAR/suPARAvB3 integrin signaling at the glomerular filtration level in health and diabetic disease (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Hypothetical driver pathways for BRCA carcinogenesis and progression (2017, Homo sapiens,Venustaconcha ellipsiformis)
• Known KEGG pathway knowledge in cancer (2017, Homo sapiens,Venustaconcha ellipsiformis)
• Mechanisms governing TGFB1–induced HASM contraction (2017, Homo sapiens)
• Signaling and crosstalk associated with relaxin activation of its receptor RXFP1 (2017, Homo sapiens)
• Integration of metabolic and fatty acids (FAs) metabolizing enzymes pathway in mitochondrial dysregulation, fibrotic hypertrophy, and chronic inflammation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Moloney murine leukemia virus)
• Proposed role of ARRB1, CALM3, FLNA and HTT in OSCC (2017, Homo sapiens,Gorilla gorilla)
• Schematic model of the regulatory role of ADAR1 in liver homeostasis (2017, Homo sapiens,Mus musculus)
• Possible schematic model of SNIPER(TACC3)‐induced death in cancer cells (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• PPI network of new predicted LUAD-related genes (2017, Homo sapiens,Mus musculus)
• Amyloidogenic and non-amyloidogenic processing of the APP (2017, NA)
• Ubiquitin editing in the Imd-signaling pathway (2017, NA)
• Possible biosynthetic pathway of ambuic acid and its analogs (2017, NA)
• ENOs and 14-3-3 in neurodegeneration (2017, NA)
• AUTS2-Rac signaling pathways in neuronal migration and neuritogenesis (2017, Homo sapiens,Mus musculus,Danio rerio)
• S1P/S1P5pathway in mitotic regulation (2017, Mus musculus,Homo sapiens)
• PD-L1表达与EGFR信号通路关系The relationship between PD-L1 expression and EGFR pathway (2017, NA)
• HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease (2017, NA)
• Infection of virus can stimulate airway epithelium and produce antimicrobiota defense through IL-22/IL-22R signaling pathway (2017, NA)
• Illustration of Wnt signaling cascades (2017, NA)
• Disease module predicted by GLADIATOR for hyperinsulinism (2017, NA)
• Adipocytes export fatty acids during times of energy deficit (involved pathways are marked with green arrows) (2017, NA)
• Schematic diagram of the cross-talk between SDF-1A and TGFB1 during SDSCs migration and chondrogenesis (2017, Homo sapiens)
• Biochemical and metabolic changes within the tumor (2017, NA)
• Proposed model for P2Y6-mediated suppression of gastric tumorigenesis through SOCE/Ca2+/Beta-catenin signaling pathways (2017, NA)
• FcGR-mediated phagocytosis canonical pathway utilisation per condition (2017, Mycobacterium tuberculosis,Homo sapiens)
• T-Lymphocyte Homing: An Underappreciated yet Critical Hurdle for Successful Cancer Immunotherapy (2017, Homo sapiens,Mus musculus)
• NFKB Activation in primary CNS lymphoma (2017, NA)
• Urinary excretion of citric acid (TCA) cycle metabolites and the renal expression of genes that regulate these metabolites were significantly reduced among participants with versus without non-diabetic CKD (2017, NA)
• Role for the MAPK p38 signaling pathway in cellular response to 5-FU (2017, NA)
• ROS/Akt/p38 MAPK signaling pathway in COM crystals-induced tight junction disruption (2017, NA)
• Principal mechanisms of parathyroid hormone signaling in bone (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Mouse mammary tumor virus,Bikinia letestui)
• Intracellular signaling pathways associated with IR-induced cell death modalities (2017, NA)
• Pathways involved in apoptotic and EMT effect by genistein in HT-29 cells (2017, Homo sapiens,Mus musculus,Capra hircus,Zingiber officinale)
• T cell gene expression analyses of T cells from sargramostim-treated or placebo-treated PD patients (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Mycobacterium tuberculosis variant bovis BCG,Fundulus heteroclitus)
• Interferon synthesis and signaling pathways (2017, NA)
• E5 immune evasion mechanisms (2017, NA)
• EGF-R and TGFB signaling pathways interfered by E5 (2017, NA)
• Characterization of central metabolic model in developing L (2017, Lindera glauca)
• Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans (2017, NA)
• Endosomal transport channels and regulation of lipoprotein-derived cholesterol in hepatocytes.In many models, it was thought that cholesterol from all sources would enter a common regulatory pool before subsequent trafficking and regulatory steps (2017, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Saccharomyces cerevisiae,Caenorhabditis elegans,Candida dubliniensis,Manduca sexta,Homo sapiens,Danio rerio,Sus scrofa)
• Genes involved in B-cell receptor signaling which converges to mitogen-activated protein (MAP) kinase pathway, nuclear factor KB (NFKB) pathway, and phosphoinositide 3-kinase (PI3K) pathway are the therapeutic targets of B-cell lymphomas (2017, NA)
• Regulatory T cell (Treg) action mechanisms (2017, NA)
• Strategies to generate tolDCs for clinical therapeutics (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Aspergillus fumigatus)
• Phenylacetic acid (PAA) biosynthesis pathway used in this study (2017, Escherichia coli)
• Molecular pathways around CIC in cancer (2017, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Photosensitizers in prostate cancer therapy (2017, NA)
• Canonical pathway of molecular mechanisms of cancer from IPA showing dysregulated mRNA targets along with their potential differentially expressed miRNA regulators found in Lebanese samples (2017, Homo sapiens,Sequoia sempervirens,clinical samples)
• Signaling Pathway for Tat-haFGF14–154 NeuroprotectionTat-haFGF14–154 binds to its receptor, activating the PI3K pathway, leading to CREB activation followed by the splicing of XBP1u mRNA to XBP1s mRNA in the ER (2017, NA)
• Illustration of the chondroprotective effects of sUA and the mechanisms underlying these effects (2017, NA)
• Schema depicting the Peli1-mediated pathway following SAH (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Armoracia rusticana)
• Schematic diagram of the possible signaling pathway or pathways linking increased intracellular phosphate utilization and phosphate retention (2017, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Equus caballus,Homo sapiens,Mus musculus)
• Potential usage of nanoparticles for splenic targeting (2017, NA)
• Simplified scheme of ‘the metabolic map of cancer cell' (2017, Homo sapiens,Mus musculus,Molva molva)
• KEGG pathway for PI3K-Akt signaling pathway (2017, Mycobacterium tuberculosis,Mycobacterium avium,Homo sapiens)
• KEGG pathway for Hippo signaling pathway (2017, Mycobacterium tuberculosis,Mycobacterium avium,Homo sapiens)
• Role of WIP1 phosphatase in termination of DNA damage response (2017, NA)
• Transcriptional regulation of hepatic mIndy mRNA levels in model organisms and humans (2017, NA)
• Central metabolism of T (2017, Thermovibrio ammonificans,Escherichia coli,Aquifex aeolicus,Pyrococcus abyssi,Desulfovibrio desulfuricans,Hydrogenobacter thermophilus,Aquifex pyrophilus,Desulfobacter hydrogenophilus,Terrisporobacter glycolicus,Ferroglobus placidus,endosymbiont of Riftia pachyptila,Caminibacter mediatlanticus,Persephonella marina,Hydrogenobacter thermophilus TK-6,Thermosulfidibacter takaii ABI70S6,Hydrogenothermus marinus,Aquifex aeolicus VF5,Sulfurihydrogenibium azorense,Hydrogenobaculum acidophilum,Hydrogenobacter hydrogenophilus,Hydrogenobaculum sp. Y04AAS1,Nitratiruptor sp. SB155-2,bacterium sp. OF1,Sulfurihydrogenibium sp. YO3AOP1,Desulfurobacterium thermolithotrophum,Sulfurihydrogenibium subterraneum DSM 15120,Desulfurobacterium sp. TC5-1,Persephonella sp. IF05-L8,Persephonella marina EX-H1,Magnetococcus marinus MC-1,Sulfurihydrogenibium subterraneum,Persephonella guaymasensis,Desulfurobacterium indicum,Desulfurobacterium sp.,Sulfurihydrogenibium azorense Az-Fu1,Sulfurihydrogenibium sp.,Balnearium lithotrophicum,Hydrogenivirga caldilitoris,Thermocrinis minervae,Hydrogenivirga sp. 128-5,Caminibacter mediatlanticus TB-2,Hydrogenivirga sp. 128-5-R1-6,Hydrogenivirga sp. 128-5-R1-1,Venenivibrio stagnispumantis,Thermosulfidibacter takaii,Ammonifex degensii,Sulfurihydrogenibium yellowstonense SS-5,Thermocrinis albus DSM 14484,Thermovibrio ammonificans HB-1,Thermocrinis ruber,Desulfurobacterium thermolithotrophum DSM 11699,Thermocrinis albus DSM 12173,Phorcysia thermohydrogeniphila,Arabidopsis thaliana,Carica papaya,uncultured bacterium,Trachipleistophora hominis,uncultured bacterium Of23,uncultured bacterium yo3,Riftia pachyptila,Alvinella pompejana,Homo sapiens,NA)
• CD19 is the linchpin between CXCR4, the BCR, and the actin cytoskeleton (2017, NA)
• Biosynthetic gene cluster and proposed biosynthetic pathway of A201A (1) in M (2017, Homo sapiens)
• Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice (2017, NA)
• Immune responses to pathogens (2017, NA)
• Schematic representation showing the link between the choline synthesis and the Wnt-mediated Beta-catenin pathway (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Glucose-stimulated insulin secretion pathway (2017, NA)
• Enhanced anabolic PI3K/Akt pathway in a cancer cell (2017, NA)
• H1 involvement in the repression of the interferon response (2017, NA)
• Redding’s summary of RT and/or chemotherapy (CT)-induced oral mucositis pathobiology () (2017, Homo sapiens)
• Regulation of IL-1/18 production and current IL-1/18 antagonists (2017, NA)
• MYCN down-regulation by didymin and based on network analyses of our proteomic studies that focused on cancer-related pathways active in NB cells (2017, NA)
• Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells (2017, NA)
• Changes in expression of genes involved in nitrogen assimilation and carbon metabolism (2017, NA)
• Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro (2017, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Human endogenous retrovirus)
• Metabolic and fitness determinants for in vitro growth and intestinal colonization of the bacterial pathogen Campylobacter jejuni (2017, NA)
• Cholesterol metabolism controls plasmacytoid dendritic cell (PDC) innate functions (2017, unidentified influenza virus,ssRNA viruses,Homo sapiens,Mus musculus,human gut metagenome,NA,NA)
• Metabolic changes in plasmacytoid dendritic cells (PDC) providing energy and affecting their innate immune functions: glycolysis versus fatty acid oxidation coupled with OXPHOS (2017, unidentified influenza virus,ssRNA viruses,Homo sapiens,Mus musculus,human gut metagenome,NA,NA)
• Predicted synthesis pathway for the t6A modification and its derivatives in H (2017, Homo sapiens,Saccharomyces cerevisiae)
• KA receptors contributes to the regulation of synaptic transmission and presynaptic LTP in cingulate cortex (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• The tentative pathway involved in IL-33 augmentation by PGE2 (2017, NA)
• Illustration of autocrine and paracrine signaling pathways in colorectal cancer (2017, Homo sapiens,Mus musculus,NA)
• Canonical Pathway of ‘Molecular Mechanisms of Cancer’ (IPA, p-value 0.0199) (2017, Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Leptospira kmetyi)
• Canonical Pathway of ‘CREB Signaling in Neurons’ (IPA, p-value 3.02E-05) (2017, Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Leptospira kmetyi)
• Characterization of microRNAs expression profiles in human dental-derived pluripotent stem cells (2017, NA)
• Hh signaling and how pathogens may modify pathway activity (2017, NA)
• Signal pathway of the immune inhibitory receptors.Notes: PD-1 crosslinks the TCR and recruits the SHP-2, which can dephosphorylate the ZAP-70 to prevent the SLP-76 and LAT from being phosphorylated (2017, NA)
• PD-1 and CTLA4: Two checkpoints, one pathway? (2017, Homo sapiens,Mus musculus)
• Repression of or mutation in several upstream regulators of homologous recombination (HR) can be synthetically lethal with PARP1 inhibition because they can cause a variety of HR repair defects that prevent fork restart (2017, NA)
• Interstrand crosslinks can be repaired by replication-independent (left) and replication-dependent (right) mechanisms (2017, NA)
• DNA repair pathways in mammalian cells (2017, NA)
• MAPK signaling pathway (2017, Homo sapiens,Mus musculus,Mycobacterium tuberculosis)
• Several roles of scrapie responsive gene 1 (SCRG1) suggested in this study and our previous reports (2017, NA)
• Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma (2017, Homo sapiens,Mus musculus)
• Comprehensive analysis of a microRNA expression profile in pediatric medulloblastoma (2017, Homo sapiens,Mus musculus)
• Chemical synthesis of n-butyraldehyde from petrochemical feedstock (2017, Escherichia coli,Homo sapiens)
• EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration (2017, Homo sapiens,Drosophila melanogaster)
• Regulation mechanisms of Cav-1 on oxidative stress (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,Rous sarcoma virus)
• Model depicting the mechanisms by which TIEG1 modulates canonical Wnt pathway activity in osteoblasts (2017, NA)
• Curcumin plays a protective role at the priming and the activation stage of renal fibrosis (2017, NA)
• Main genetic and signaling pathway alterations in UMs and CMs (2017, Saccharomyces cerevisiae,Agaricus bisporus,Homo sapiens,Mus musculus,Ovis aries)
• Diagram of heme effect (2017, NA)
• Pathogen Effector Proteins Enhance Susceptibility by Interfering with PRR-Mediated Signaling or Mimicking Peptide Hormones.Different effectors and molecular patterns are colored in purple (2017, NA)
• Most significant canonical pathway from the gene list obtained from the esciptalpram versus control analysis (2017, NA)
• Top ranking gene network by gScore from the gene list uploaded from the SSRI versus control analysis (2017, NA)
• Top ranking gene network by P‐value from the gene list uploaded from SSRI versus control group analysis (2017, NA)
• Top ranking gene network by gScore from the gene list uploaded from the NRI versus control analysis (2017, NA)
• Top ranking gene network by P‐value from the gene list uploaded from the NRI versus Control analysis (2017, NA)
• Regulation of HIF1A under normoxia and hypoxia conditions (2017, Homo sapiens,Bos taurus)
• Schematic diagram of Bc-specific induction of regulatory T cells via suppression of mTOR signaling pathway (2017, Lactiplantibacillus plantarum,Lacticaseibacillus rhamnosus,Streptococcus thermophilus,Bifidobacterium breve,Bifidobacterium longum subsp. infantis,Lactobacillus gasseri,Weizmannia coagulans,Bacillus infantis,Penaeus monodon,Metapenaeus ensis,Penaeus aztecus,Bathymodiolus thermophilus,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Arachis hypogaea)
• Mechanisms of GPC3 in acute lung injury (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Ginkgo biloba)
• Positive and negative effects of GPC3 on its two main signaling pathways (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Ginkgo biloba)
• An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice (2017, NA)
• Gene expression level changes in ethanol synthesis pathway (2017, Saccharomyces cerevisiae,Homo sapiens)
• Hypothetical schematic of the physiological and pathophysiological roles of Notch signalling in articular cartilage (2017, Homo sapiens,Mus musculus)
• Illustrative scheme of Gq-protein (Gq)-mediated S1P effects in glioblastoma (2017, Mus musculus,Rattus norvegicus,Homo sapiens,AKT8 retrovirus)
• Proposed mechanism whereby SM70EE ameliorates learning and memory impairments in mice with an intracerebroventricular injection of amyloidB 1–42 (AB1–42) (2017, NA)
• Nucleotide excision repair and the ATR-CHK1-mediated DNA damage checkpoint (2017, NA)
• Action network of predicted targets of miRNAs overexpressed in GML mice stomachs (2017, NA)
• Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NFKB pathway (2017, Armoracia rusticana,Diaporthe sclerotioides,Ginkgo biloba,Morus alba,Alpinia conchigera,Rosa agrestis,Wissadula periplocifolia,Calligonum polygonoides,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Escherichia coli,Opsanus beta,Enterobacteria phage A549)
• Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells (2017, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli PBD1,Escherichia coli PBD2,Escherichia coli PBD3,Bos taurus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Mus musculus,Gallus gallus,Armoracia rusticana,Porcine epidemic diarrhea virus,Cloning vector pEGFP-N1)
• Metabolic heterogeneity signature of primary treatment-naïve prostate cancer (2017, NA)
• Network analysis by Ingenuity®Pathway Analysis (IPA) indicated molecules associated with rheumatic disease and inflammation of joint (2017, NA)
• Current possible strategies to bypass AVPR2 mutations responsible for X-linked NDI (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Xenopus laevis)
• Ingenuity Pathway Analysis cancer network from RNA-Seq breast cancer samples (2017, NA)
• Sequential molecular mechanisms involved in FLX-induced cholestasis (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Triportheus paranensis)
• Pathway of “aryl hydrocarbon receptor signaling”-initiated smoking-related cancer (2017, NA)
• Proposed mechanism by which HBV hijacks IFN/JAK/STAT pathway via activating SOCS2 to facilitate immune evasion and viral infection (2017, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides,Hepatitis B virus,NA)
• Summary of the main effects of diabetes and NRG1 treatment in gastrocnemius muscle (2017, NA)
• PI3K/Akt/mTOR signaling pathway and pharmacological compounds used to modulate its activity (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer (2017, NA)
• Representative schematic of the proposed TRIF contribution to NFKB-dependent TNFA promoter activation (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Escherichia coli,Brucella abortus,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Glycerophospholipid metabolism is induced in parasitized A (2017, NA)
• AMP-activated protein kinase (AMPK) plays a double-edged role in cancer (2017, NA)
• Pathway showing role of Ror1in promoting tumor-cell growth, (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Chemokine signalling pathway (source-http://www.kegg.jp/kegg/kegg1.html) (2017, NA)
• Distribution of Turkish galls target proteins on the compressed UC pathway (2017, Triportheus paranensis,Opsanus beta,Glyptocephalus cynoglossus,Mus musculus,Rattus norvegicus,Syzygium aromaticum,Quercus infectoria,Homo sapiens,Bos taurus,Campylobacter jejuni,Anopheles stephensi)
• Mechanisms involved in the antagonist effect of sinapic acid against UVA-induced attenuation of stemness and differentiation properties of stem cells (2017, Armoracia rusticana,Oryza sativa,Brassica juncea,Polygala tenuifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Host miRNAs that favor viral replication via the inhibition of the Jak/STAT signaling pathway (2017, NA)
• Schematic diagram showing the mechanisms by which miR-1224-5p regulates silica-induced pulmonary fibrosis (2017, NA)
• Metabolic reprogramming and an altered intercellular communication are hallmarks of cancer cells (2017, NA)
• Nuclear factor erythroid 2-related factor 2 (Nrf2) regulatory pathway (2017, NA)
• Graphical summary of inter-variable connections for the entire BiliHealth study population (2017, Homo sapiens,Escherichia coli,Nicotiana tabacum)
• DEGs related to fatty acid degradation and PPARA signaling pathway between APFL and AP (2017, Homo sapiens,Rattus norvegicus,Cymbidium sinense)
• The mechanism of Salvia fruticosa-induced relaxation of rat isolated aorta (2017, NA)
• Neuroprotective action of MMP-9 in preventing ABeta-mediated impairment of the insulin survival pathway (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Lippia florida,Homo sapiens)
• Signaling transduction pathway of AMSC differentiation to ECs and negative crosstalk between ERK and JNK (2017, NA)
• Differentiation of naïve Th cells into Th2 cells (2017, Glycine max,Triticum aestivum,Malus domestica,Arachis hypogaea,Daucus carota,Prunus persica,Musa acuminata,Actinidia deliciosa,Persea americana,Bos taurus,Canis lupus familiaris,Blattella germanica,Geckobia sp. A,Homo sapiens,Mus musculus,Lactococcus lactis,NA)
• KEGG analysis of upregulated and downregulated promoter DMGs showing involvement in a metabolic pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Main potential molecular mechanism of the antitumour effect of anthocyanins in vitro (2017, NA)
• Oestrogen receptor and polyphenols – a proposed mechanism of action, taking into account two main ERs regulatory actions; classical (direct) and tethered pathway (2017, NA)
• Action of branch‐chained amino acids (BCAAs) (2017, Homo sapiens)
• Genome-wide transcriptome profiling of radish (Raphanus sativus L.) in response to vernalization (2017, NA)
• Meta Core pathway analysis indicated that cardiac hypertrophy signaling was significantly associated with sesamin-treated samples (P=1.148E-10) (2017, herbal medicine,Olea europaea,Panax ginseng,Sesamum indicum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Transcriptome pattern differs between two oil biosynthesis tissues in oil palm (2017, NA)
• Model depicting the involvement of autophagy-lysosomal system in apigenin-induced degradation of Beta-catenin during Wnt signaling (2017, Saccharomyces cerevisiae,Lareunionomyces loeiensis,herbal medicine,Petroselinum crispum,Apium graveolens Dulce Group,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Chlorocebus aethiops,Mus musculus)
• Proposed model for the suppression of inflammatory cytokine production by globular adiponectin in LPS-stimulated macrophages (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• The putative signaling pathways underlying the migration-stimulating effect of c-MWCNTs on RAW264.7 macrophages based on the present study and related reports (2017, NA)
• Schematic overview summarizing the functional significance and regulation of COX-2 in PDAC (2017, NA)
• Influence of Nitric Oxide generated through microwave plasma on L6 skeletal muscle cell myogenesis via oxidative signaling pathways (2017, NA)
• Proposed action mechanism responsible for the suppressive effects of RDSW on the LPS-induced inflammatory signaling pathway (2017, NA)
• Reactome pathways displayed in Figure were converted into a functional interaction network using FI network view (2017, Homo sapiens,Caenorhabditis elegans,Candida dubliniensis)
• Cilia-dependent mTOR signaling (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,NA)
• Proposed signalling pathway showing that genetic loci deregulated through altered methylation in Beckwith-Wiedeman syndrome are upstream of pheochromocytoma-paraganglioma susceptibility genes (2017, NA)
• Protective effects and functional mechanisms of Lactobacillus gasseri SBT2055 against oxidative stress (2017, NA)
• Cell signaling pathway scheme of metabolic alterations due to Zika virus infection (2017, NA)
• Akt/mTOR pathway represents a major axis of phosphorylation signal transduction in response to phagocytosis (2017, Homo sapiens,Mus musculus)
• Effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis (2017, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Equus asinus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Network fabricated in CellDesigner (2017, Homo sapiens,Rattus norvegicus,Escherichia coli,Caenorhabditis elegans,Corynebacterium phage gamma)
• Analogue signalling pathway of TXNIP mediated by ER stress may be a novel therapeutic target in SAH-related EBI (2017, NA)
• Schematic comparison between glucose (orange) and xylose (blue) metabolisms in engineered S (2017, NA)
• Engulfment by follicle cells in the Drosophila ovary (2017, NA)
• Proposed schema on inhibitory effects of nicotine on LPS-induced microglial activation (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Signaling pathway whereby nNOS acts through peroxynitrite to trigger hippocampal ER stress and oxidative damage in PTZ-kindled epileptic conditions (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Diaporthe sclerotioides)
• Targeted therapy in extranodal marginal zone lymphoma (2017, Helicobacter pylori,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia psittaci,Achromobacter xylosoxidans,Chlamydia abortus,Helicobacter heilmannii,Homo sapiens,NA)
• Hsp70 in signal transduction pathways (2017, NA)
• Pathway hyperactivation defined by alterations of the PI3K/AKT/mTOR pathway (2017, NA)
• Leukocyte extravasation signaling pathway (2017, NA)
• Hypothetical pathways through which albumin overload promotes renal fibrosis via epigenetic regulation of miR-184 (2017, NA)
• Regulation of the NFKB signaling pathway by MALT1 and BIRC3-MALT1 (2017, Helicobacter pylori,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia psittaci,Achromobacter xylosoxidans,Chlamydia abortus,Helicobacter heilmannii,Homo sapiens,NA)
• Canonical and non-canonical NFKB signaling pathways (2017, Helicobacter pylori,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia psittaci,Achromobacter xylosoxidans,Chlamydia abortus,Helicobacter heilmannii,Homo sapiens,NA)
• Immunohaemostasis and infection (2017, NA)
• Illustration of three major metabolic pathways responsible for plasmalogen reduction (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Anarhichas lupus)
• Alterations in DNA methylation patterns as a source of cancer progression traits (2017, NA)
• Metastatic niches in the bone marrow (2017, NA)
• Model depicting targets of CHOP-dependent apoptosis (2017, Homo sapiens)
• A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis (2017, NA)
• Molecular mechanisms involved in macrophage inflammatory protein-2 secretion of macrophages (2017, NA)
• Hunger-satiety circuit and energy balance (2017, Nicotiana tabacum,Candida dubliniensis,Erythroxylum coca,Mus musculus,Rattus norvegicus,gut metagenome,human metagenome,Homo sapiens,Escherichia coli,Canis lupus familiaris)
• Mechanism by which HSF1 regulates pancreatic cancer cell apoptosis (2017, Homo sapiens,Mus musculus,Bos taurus)
• Hippo–YAP pathway mediates physiological resistance to gemcitabine (2017, Homo sapiens,Mus musculus)
• CD40-mediated apoptosis in carcinoma cells (2017, NA)
• Proposed signaling pathways involved in TP-induced hepatotoxicity (2017, NA)
• Autoantibodies in the pathogenesis of Graves’ orbitopathy (2017, NA)
• TGFB1-mediated regulatory network via Ingenuity pathway analysis (2017, Homo sapiens,Saccharomyces cerevisiae)
• P53-mediated regulatory network via Ingenuity pathway analysis (2017, Homo sapiens,Saccharomyces cerevisiae)
• Visual overview of the c-MET/HGF signaling pathway with different biological effects and also of representative imaging agents targeting to either extracellular or intracellular domains of c-MET receptor (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Diaporthe sclerotioides,Triportheus paranensis)
• Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models (2017, Homo sapiens,Bos taurus)
• Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis (2017, NA)
• Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis (2017, NA)
• Shear Stress in Autophagy and Its Possible Mechanisms in the Process of Atherosclerosis (2017, NA)
• Synthesis of the LLO analogs used in this study (2017, NA)
• Gene expression changes in the TGFB signaling pathway (2017, Danio rerio,Xenopus laevis,Dipnomorpha,Tetrapoda,Pelobates cultripes,Mus musculus,Rattus norvegicus,Phodopus sungorus,Homo sapiens,Oryctolagus cuniculus)
• Gene expression changes in the Wnt/Beta-catenin signaling pathway (2017, Danio rerio,Xenopus laevis,Dipnomorpha,Tetrapoda,Pelobates cultripes,Mus musculus,Rattus norvegicus,Phodopus sungorus,Homo sapiens,Oryctolagus cuniculus)
• mTOR signaling pathway in podocyte autophagy (2017, NA)
• MM Expressing Active RKIP (2017, Homo sapiens,Mus musculus)
• Immune exclusion through Wnt/beta-catenin pathway: Activation of Wnt/beta-catenin pathway in tumor leads to noninflammatory milieu through multiple mechanisms (2017, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Therapeutic targets in Wnt/Beta-catenin pathway and developmental therapeutics (2017, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis (2017, NA)
• Blocking Smad2 signalling with loganin attenuates SW10 cell cycle arrest induced by TNFA (2017, NA)
• Module style view of JA signalling network (directed graph) node (square box) with catalysis (red color), and physical stimulation (black color) (2017, Arabidopsis thaliana)
• Proposed model of the interplay between the GASpathway and the K2P channel TWK-7 in Gamma-aminobutyric acid (GABA)ergic motor neurons of C (2017, Caenorhabditis elegans,Homo sapiens)
• NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans (2017, NA)
• Jasmonate singaling pathway map was constructed by CellDesigner4.4 using systems biology graphical nonation (SBGN) (2017, Arabidopsis thaliana)
• Innate immune signaling pathways that drive type I IFN responses in mycobacteria-infected host cells (2017, Mycobacterium tuberculosis,Homo sapiens)
• Nicotinamide/NAD and tryptophan metabolism are linked by the ‘de novo’ pathway (2017, NA)
• Diet supplies nicotinamide, nicotinic acid, and nicotinamide riboside as well as the essential amino acid tryptophan (2017, NA)
• Non-canonical regulation of HIF-1A stability (2017, Homo sapiens,Mus musculus,Dipturus trachyderma)
• Physiological Nitric Oxide (NO) formation pathways (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Proposed potential mechanism of the cardol-induced apoptotic pathway in SW620 cells (2017, NA)
• Tumour angiogenesis: molecular pathways and potential interventional strategies (2017, NA)
• PD-1:PD-L1 mechanisms between T-cells and tumor cells (2017, NA)
• Roles and modulations of toll-interacting protein (Tollip) in acute and chronic inflammation (2017, NA)
• Insulin/insulin growth factor signaling pathway and its activation by reactive oxygen species (ROS) (2017, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Zoysia japonica,Homo sapiens)
• Negative feedback regulates the RAS/MAPK pathway (2017, NA)
• Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut (2017, Dengue virus,Vesicular stomatitis virus,Enterococcus faecalis,Lactiplantibacillus plantarum,Drosophila C virus,Acetobacter pomorum,Homo sapiens,Mus musculus,Drosophila melanogaster,Candida dubliniensis)
• Transcriptome analysis of muskrat scented glands degeneration mechanism (2017, Saccharomyces cerevisiae,Glycine max,Olea europaea,Castanea mollissima,Castanea dentata,Mus musculus,Rattus norvegicus,Scapteromys aquaticus,Ondatra zibethicus,Homo sapiens,Mustela lutreola)
• Transcriptome analysis of muskrat scented glands degeneration mechanism (2017, Saccharomyces cerevisiae,Glycine max,Olea europaea,Castanea mollissima,Castanea dentata,Mus musculus,Rattus norvegicus,Scapteromys aquaticus,Ondatra zibethicus,Homo sapiens,Mustela lutreola)
• Interactome of lupus susceptibility genes, constructed using Strings software (version 9.0; http://string-db.org) via evidence‐based protein–protein interactions (2017, NA)
• Metabolic pathways controlling activation and lineage specification in the immune system (2017, NA)
• Downregulated transcripts related to P (2017, Paracoccidioides brasiliensis,Homo sapiens)
• Schematic summary of the IL-1B–IL-1 receptor signaling cascades identified in decidualizing human ESCs (2017, Homo sapiens)
• Pathview () plot of the KEGG () pathway showing the Cell mitotic cycle ('HSA 04110') superimposed with RNA-seq expression data corresponding to the log2 -transformed fold change in expression of cell cycle transcripts from HIOs microinjected with E (2017, Escherichia coli,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Clostridioides difficile,Escherichia coli str. K-12 substr. MG1655,Bifidobacterium bifidum,Bifidobacterium longum subsp. infantis,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,gut metagenome,human gut metagenome,Homo sapiens,Danio rerio,Ulex europaeus)
• Central role of mitochondria in energy production, biosynthesis, and redox regulation (2017, NA)
• Reverse cholesterol transport pathway (2017, NA)
• Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling (2017, NA)
• Molecular insights into desmoid tumors (2017, Homo sapiens,Mus musculus)
• RICTOR is upstream of multiple canonical pathways (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Canonical pathways form groups for each individual protein (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• RLR-mediated RNA sensing pathways (2017, NA)
• cGAS-STING pathway senses cytosolic dsDNA (2017, NA)
• The mode of action of the major drugs with trypanocidal activity (2017, NA)
• Three interconnected intracellular signaling pathways in pancreatic B cells (2017, Homo sapiens,Mus musculus)
• Anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways (2017, Pseudomonas aeruginosa,Homo sapiens)
• Clinically relevant inhibitors of the isoprenoid biosynthetic pathway (IBP) (a) Statins inhibit HMG CoA reductase, consequently reducing the entire IBP (2017, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Mast cells and their receptors (2017, NA)
• Transforming growth factor B (TGFB)-induced transcriptional program and its alterations in cancer (2017, NA)
• Transforming growth factor B (TGFB)-induced Smad signaling pathway (2017, NA)
• AMPK pathway (2017, Saccharomyces cerevisiae,Allium sativum,Panax quinquefolius,Hibiscus sabdariffa,Undaria pinnatifida,Calluna vulgaris,Bos taurus,Sus scrofa,Homo sapiens,Rattus norvegicus)
• PI3K/AKT pathway (2017, Saccharomyces cerevisiae,Allium sativum,Panax quinquefolius,Hibiscus sabdariffa,Undaria pinnatifida,Calluna vulgaris,Bos taurus,Sus scrofa,Homo sapiens,Rattus norvegicus)
• TNF-induced canonical NFKB and apoptosis pathways (2017, NA)
• Hippo signaling pathway (2017, NA)
• Generalized schematic of checkpoint molecule structure and expression, and the balance between stimulatory and inhibitory signaling (2017, NA)
• TGF‐B1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up‐regulation of IL‐17RB (2017, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Bromus secalinus,Homo sapiens,Coturnix coturnix)
• An example of innate immune response induced by E2 in ML-1 cells (2017, Homo sapiens,NA)
• Canonical (NFKB1) pathway requires the NEMO (NFKB essential modulator) complex (IKB kinase A, IKB kinase B, IKB kinase G) to phosphorylate IKB, leading to its degradation (2017, NA)
• CD30 mediates its effects through a number of diverse signaling pathways, which in concert confer a survival benefit to the cells on which CD30 is upregulated (2017, NA)
• Culturing human intestinal stem cells for regenerative applications in the treatment of inflammatory bowel disease (2017, NA)
• Neural ectoderm and neural crest specification in deprivation of the external signals.A (2017, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• TRAIL‐ and TNF‐induced signaling complexes—so similar yet so different (2017, NA)
• Schematic presentation of the postsynaptic structure and function on the basis of acetylcholine receptor clustering centered on agrin- and Wnt-signalings, trans-synaptic communication and synaptic stabilization (2017, NA)
• Direct or indirect protein-protein interaction of AmotL2, FKBP51, IQGAP2 and interacting partners (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Danio rerio,Serinus canaria,Homo sapiens,Mus musculus)
• Isotopomer formation through carbon distribution of [1,2-13C2]-glucose (2017, NA)
• The transforming growth factorB (TGFB) pathway (2017, Homo sapiens,Mus musculus)
• Panx1- and Cx-dependent mechanisms leading to platelet aggregation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• A possible mechanism for the regulation of adipogenic differentiation by RAR agonists and RXR agonists in hBMSCs (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Mouse mammary tumor virus)
• Specific elements of the canonical pathway for modulation of gene expression that are activated after 15 min of exposure of U118MG cells to 25 µM of PK 11195, as uncovered by “Regulator Effects” analytic (IPA®) (2017, NA)
• The VEGF/VEGFR/HIF-1A signaling pathway and the effects of melatonin treatment leading to the activation or repression of downstream molecules in OC cell (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Sesamum indicum)
• Current strategies for targeting the epidermal growth factor receptor (EGFR) pathway (2017, NA)
• Immunomodulatory activity of FTY720P (2017, NA)
• DEGs protein–protein interaction (PIP) network complex and modular analysis (2017, NA)
• Antifibrosis mechanisms of QSKL on the RhoA/ROCK and MAPK pathways (2017, NA)
• IPA generated pathway prediction for the NRF2-mediated oxidative stress response in the small intestine (2017, NA)
• Combined gene expression and predicted activation information for the mTOR pathway in the heart and small intestine (2017, NA)
• Cell fate decisions: emerging roles for metabolic signals and cell morphology (2017, NA)
• TNF‐p100 pathway subverts noncanonical NF‐KB signaling in inflamed secondary lymphoid organs (2017, Mus musculus,Homo sapiens)
• Role of PI3K-Akt signaling cascade in TUS attenuates intrinsic apoptosis in HUVECs (2017, Homo sapiens)
• Postulated interaction between enzastaurin and erlotinib in the EGFR pathway (2017, NA)
• Hedgehog (Hh) signal transduction in the primary cilium (2017, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Drosophila melanogaster,unidentified)
• Hypothesized altered feedback control of the POMC gene promoter in cells having USP8 or RASD1 mutations (mut) versus wild type (wt) (2017, NA)
• Interactome of negatively and positively changed genes comparing differentiated NIKS with differentiated NIKS16 cells (2017, NA)
• Cellular and molecular pathogenesis of Helicobacter pylori infection in gastric carcinogenesis (2017, NA)
• Proteostasis network and ALS (2017, NA)
• Emerging mechanisms underlying astrogenesis in the developing mammalian brain (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Schematic presentation of a single neuron affected by the prion fibrils and oligomers (2017, prion,Homo sapiens)
• The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases (2017, prion,Homo sapiens)
• Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway (2017, Armoracia rusticana,herbal medicine,Tanacetum parthenium,Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Proposed ferritin-mediated feed-forward inflammatory loop (2017, NA)
• Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) (2017, NA)
• Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) (2017, NA)
• Comparative transcriptome and potential antiviral signaling pathways analysis of the gills in the red swamp crayfish, Procambarus clarkii infected with White Spot Syndrome Virus (WSSV) (2017, NA)
• Curcumin induced autophagy via the ERK1/2 signal pathway to protect chondrocytes from apoptosis (2017, Homo sapiens,Rattus norvegicus,Bos taurus,Curcuma longa)
• Possible mechanisms of action of BRB in esophageal cancer prevention (2017, NA)
• Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance (2017, NA)
• Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance (2017, NA)
• Epidermal growth factor receptor (EGFR), signal transducer and activator of transcription 3 (STAT3), and Src-YES-associated protein 1 (YAP1) crosstalk (2017, NA)
• Schematic diagram of the proposed signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus)
• Synergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of Beta-catenin (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Danio rerio)
• TNF/TNFR pathway is targeted by human immunodeficiency virus 1 (HIV-1) proteins (2017, Human immunodeficiency virus 1,Human immunodeficiency virus,Simian immunodeficiency virus,Mycobacterium tuberculosis,Mycobacterium tuberculosis SP1,Homo sapiens,Mus musculus,Candida dubliniensis,NA)
• Tumor necrosis factorA (TNF)/TNF receptor (TNFR)-mediated cell signaling (2017, Human immunodeficiency virus 1,Human immunodeficiency virus,Simian immunodeficiency virus,Mycobacterium tuberculosis,Mycobacterium tuberculosis SP1,Homo sapiens,Mus musculus,Candida dubliniensis,NA)
• HFD activates genes involved in inflammation and tumorigenesis (2017, Homo sapiens,Mus musculus)
• Metabolite and transcript pathway network analysis of soybean responses to R (2017, Arabidopsis thaliana,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Vitis vinifera,Phytophthora infestans,Ustilago maydis,Panicum miliaceum,Sclerotinia sclerotiorum,Rhizoctonia solani,Fulvia fulva,Blumeria graminis,Vitis labrusca,Zymoseptoria tritici,Phytophthora ramorum,Colletotrichum lindemuthianum,Salix purpurea,Rhizoctonia solani AG-1,Rhizoctonia solani AG-1 IA,Homo sapiens,Venustaconcha ellipsiformis,Pseudomonas syringae)
• Calmodulin (CaM) with phosphorylated tyrosine 99 (pTyr99) in KRAS-driven adenocarcinoma (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Toll-like receptor signaling pathways (2017, NA)
• Mitochondrial Control of Innate Immunity and Inflammation (2017, NA)
• Mitochondrial Control of Innate Immunity and Inflammation (2017, NA)
• Management of EGFR-mutated non-small-cell lung cancer: practical implications from a clinical and pathology perspective (2017, NA)
• IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria (2017, NA)
• Action of the phytochemical compounds of tucum-do-cerrado in the prevention of aging, by the upregulation SIRT1-Nrf2 pathway, attenuating oxidative stress and inflammation, in the liver (2017, NA)
• ATM (ataxia telangiectasia mutated)-mediated DDR (DNA damage response) signaling pathway (2017, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human gammaherpesvirus 8,Homo sapiens,Saccharomyces cerevisiae,NA)
• Crosstalk network amid Alzgset-overrepresented pathways (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida dubliniensis,Enterovirus C,Avian sarcoma virus CT10,Homo sapiens,Drosophila melanogaster,gut metagenome)
• Summary of the survival and growth phenotypes in breast cancer (2017, NA)
• Ways of targeting MYC and its transcriptional output using specific signaling pathway, BET bromodomain, and complex inhibitors in MYC-dependent malignancies (2017, NA)
• Targeted Inhibition of Hepatocyte Growth Factor (HGF)/c-Met Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) (2017, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Nicotiana tabacum)
• PI3K pathway targeting agents in development for the treatment of prostate cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Spatial localization of functional NG2 interactions (2017, NA)
• The phosphatidylinositol-3-kinase (PI3K) pathway (2017, Homo sapiens,Mus musculus)
• EGFR family members regulate autophagy affecting cancer cell survival and death (2017, NA)
• EGFR family members contribute to cell survival through multiple mechanisms (2017, NA)
• Hypothalamic circuits regulating thermogenesis of BAT and browning of WAT (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Olea europaea)
• Combined treatment with lenvatinib plus everolimus in renal cell carcinoma (RCC) xenograft mouse models (2017, NA)
• General mechanism of the action of CIS, SOCS1, and SOCS3 (2017, NA)
• T cell immune checkpoints for anti‐tumor immunity (2017, NA)
• Insulin‐like peptide 3 (INSL3) on osteoblasts (2017, NA)
• Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster (2017, Drosophila melanogaster,Homo sapiens)
• Viral modulation of death-receptor mediated apoptosis (2017, NA)
• Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions (2017, NA)
• Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in brain (2017, Venezuelan equine encephalitis virus,Homo sapiens)
• Network analysis of inflammatory genes modulated in response to V3000 and V3034 infections in spleen (2017, Venezuelan equine encephalitis virus,Homo sapiens)
• Network analysis of apoptotic genes modulated in response to V3000 and V3034 infections in spleen at 24 h pi (2017, Venezuelan equine encephalitis virus,Homo sapiens)
• SRT1720 action.SRT1720 improves glucose homeostasis and protects against metabolic disorders by activating AMPK and Sirt1 via interlinked pathways (2017, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,vectors)
• Simplified genetic modules controlling production of the florigens in leaves (2017, NA)
• Reactive oxygen species (ROS) maintenance by redox homeostasis (2017, NA)
• Functional p53 control of cell growth and oxidative metabolism (2017, NA)
• Kreb's Cycle and oxidative phosphorylation pathways are central to cell metabolism (2017, NA)
• Hypothetical mechanism of action of BoNT/A is achieved through the modulation of TLR2 and SNARE proteins, and minocycline occurs through the modulation of p38 and MMP9 in glial cells (2017, Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Clostridium botulinum,Homo sapiens,Drosophila melanogaster,Armoracia rusticana)
• Fourteen differentially expressed unigenes (DEGs) involved in phenylpropanoid biosynthesis and peroxisome pathway showed a comprehensive pathway in response to increase of superoxide (2017, Arabidopsis thaliana,Oryza sativa,Zea mays,Triticum aestivum,Cucumis sativus,Sorghum bicolor,Phaseolus vulgaris,Musa acuminata,Cicer arietinum,Astragalus membranaceus,Trifolium pratense,Amaranthus caudatus,Cynodon dactylon,Hordeum vulgare subsp. spontaneum,Boehmeria nivea,Corchorus capsularis,Amaranthus cruentus,Malva neglecta,Corchorus olitorius)
• Association between human papillomavirus infection and lung cancer: a system review and meta-analysis (2017, NA)
• Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARGamma-Akt signaling pathway at the early stage of carcinogenesis (2017, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Meleagris gallopavo)
• Mechanism of action of various Hedgehog pathway inhibitors (2017, NA)
• Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes (2017, Homo sapiens,Mus musculus,Bos taurus,Caenorhabditis elegans)
• CYP2J2 and Its Metabolites EETs Attenuate Insulin Resistance via Regulating Macrophage Polarization in Adipose Tissue (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus)
• EGF and GLP-2 signaling to attenuate mucosal atrophy in a mouse TPN model (2017, NA)
• Pathological effects of chronic oxidative stress (2017, NA)
• Hypothetical outline of chemokine signaling cascade relayed by the urotensinergic system inducing cell migration (2017, NA)
• Enrichment of gene expression changes (p < 0.05) shared by the TCF4 small interfering RNA (siRNA)#1 and TCF4 siRNA#2 conditions in the “cell cycle” KEGG pathway (p = 0.006, Bonferroni-corrected) (2017, NA)
• PARK2 loss connects AMPK-mediated nitrosative stress to PI3K/AKT activation (2017, Homo sapiens,Mus musculus)
• Juglanin inhibits lung cancer by regulation of apoptosis, ROS and autophagy induction (2017, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Juglans regia,Polygonum aviculare,Homo sapiens,Mus musculus,Drosophila melanogaster,Japanese encephalitis virus)
• Schematic drawing demonstrating the previously uncharacterized mechanism involved in the inhibition of lipopolysaccharide (LPS)-induced inflammatory responses by ubiquitin-fold modifier 1 (Ufm1) through the nuclear factorKB (NFKB) pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus)
• Proposed mechanism for oridonin-induced G2/M arrest and apoptosis in prostate cancer cells (2017, NA)
• Activation of the Ras/Raf/MEK/ERK signaling pathway (2017, NA)
• Mechanism of action of romosozumab.Notes: Romosozumab is a human monoclonal antibody that binds sclerostin (an inhibitor of Wnt pathway signaling) (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Drosophila melanogaster,Matthiola incana)
• Profile of romosozumab and its potential in the management of osteoporosis (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Drosophila melanogaster,Matthiola incana)
• Oxidative stress injuries in COPD.Notes: Oxidative irritants including tobacco smoke directly affect the epithelial cells, macrophages, and edematous basal membrane (2017, Nicotiana tabacum,Vasconcellea candicans,Homo sapiens,Mus musculus,Staphylococcus aureus)
• Necroptosis and Cancer (2017, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Transcriptome profiling of sulfate deprivation responses in two agarophytes Gracilaria changii and Gracilaria salicornia (Rhodophyta) (2017, Gracilaria changii,Gracilaria salicornia,Homo sapiens)
• ST2/IL-33 signaling pathway (2017, Homo sapiens)
• Proposed model for PECAM-1/PI3K-mediated activation of the integrins FAK, p38, COX-2, and PGI2 in ECs exposed to FSS (2017, Homo sapiens,Mus musculus,Bos taurus)
• Schematic signal transduction network representing the observed changes in protein and lipid metabolism in eWAT during sepsis-recovery (2017, Homo sapiens,Mus musculus)
• Signaling pathways activated by peptides and amino acids involved in glucagon-like peptide 1 (GLP-1) secretion and synthesis in enteroendocrine cells (2017, NA)
• Signaling pathways activated by peptides and amino acids involved in cholecystokinin (CCK) secretion and synthesis in enteroendocrine cells (2017, NA)
• Biotic stress pathway analyses of DEGs in A (2017, Arabidopsis thaliana,Plasmodiophora brassicae,Homo sapiens)
• Vaspin signaling (2017, Homo sapiens)
• Omentin signaling (2017, Homo sapiens)
• Visfatin signaling (2017, Homo sapiens)
• Resistin signaling (2017, Homo sapiens)
• Adiponectin signaling via AdipoR1 and AdipoR2 activation (2017, Homo sapiens)
• Leptin signal transduction (2017, Homo sapiens)
• Mammalian biogenic polyamines and metabolic pathways (2017, NA)
• Downstream signaling pathways activated by metabotropic glutamate receptors (mGluR) (2017, NA)
• Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas (2017, NA)
• MicroRNAs in melanoma development and resistance to target therapy (2017, Homo sapiens,Mus musculus,clinical samples)
• Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies (2017, NA)
• Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma (2017, NA)
• Long non-coding RNAs: a rising biotarget in colorectal cancer (2017, Homo sapiens,Bacteriophage sp.)
• Involvement of inflammation and its related microRNAs in hepatocellular carcinoma (2017, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Involvement of inflammation and its related microRNAs in hepatocellular carcinoma (2017, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Involvement of inflammation and its related microRNAs in hepatocellular carcinoma (2017, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway (2017, NA)
• MiR-519d impedes cisplatin-resistance in breast cancer stem cells by down-regulating the expression of MCL-1 (2017, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana,Deinocerites cancer)
• Imidazoline I2 receptor inhibitor idazoxan regulates the progression of hepatic fibrosis via Akt-Nrf2-Smad2/3 signaling pathway (2017, NA)
• Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old (2017, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Chemical Reaction Network Theory elucidates sources of multistability in interferon signaling (2017, Homo sapiens,Saccharomyces cerevisiae,Lambdavirus lambda)
• MAPK cascade and pathway components in mammalian cells (2017, NA)
• Evolutionary life cycle of the polysaccharide biosynthetic gene cluster based on the Sphingomonadaceae (2017, NA)
• Schematic diagram for microglia‐derived basigin induction and its effect on angiogenesis (2017, NA)
• Sequential activation of polyadenylation during oocyte maturation in Xenopus (2017, NA)
• Schematic overview of underlying pathophysiology and targeted therapies in neurofibromatosis 1 (NF1)-associated malignant peripheral nerve sheath tumors (MPNSTs) (2017, NA)
• Pathway alterations in glioblastoma (2017, Homo sapiens)
• Scheme showing hyperglycemia-induced VEGF expression regulated by PRR, RAC1, and miRNA signaling (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Armoracia rusticana)
• Schematic depiction of the cross-talk between Hh signaling and DYRK kinases (2017, NA)
• Genome-wide association studies identified multiple genetic loci for body size at four growth stages in Chinese Holstein cattle (2017, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Bos taurus)
• Type I interferons (IFN-I)-initiated signaling pathway leading to interferon-stimulated gene (ISG) expression (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Simian immunodeficiency virus,Human immunodeficiency virus 2,Homo sapiens,Macaca mulatta,Chlorocebus aethiops,Cercocebus atys,Mus musculus,Simian-Human immunodeficiency virus)
• Visible model is an excerpt of the KEGG (Kyoto Encyclopedia of Genes and Genomes) FoxO signaling pathway in humans as appears after importing in bStyle (2017, NA)
• NcRNAs involved in mTOR signalling pathway (2017, Homo sapiens,Bos taurus)
• Salt suppresses IFNG inducible chemokines through the IFNGamma-JAK1-STAT1 signaling pathway in proximal tubular cells (2017, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Arabidopsis thaliana,Capra hircus,Lotus tetragonolobus,Mycobacterium tuberculosis,Mycobacterium tuberculosis SP8,Homo sapiens,Mus musculus)
• Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Helicobacter pylori-induced chronic inflammatory and neoplastic diseases (2017, NA)
• Simplified schematic depiction of the canonical hedgehog (HH) signal transduction pathway within the primary cilium (2017, NA)
• Pattern recognition receptors (PRRs) for human immunodeficiency virus type 1 (HIV-1) recognition and the following pathway for triggering type I interferon (IFN-I) expression (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Simian immunodeficiency virus,Human immunodeficiency virus 2,Homo sapiens,Macaca mulatta,Chlorocebus aethiops,Cercocebus atys,Mus musculus,Simian-Human immunodeficiency virus)
• Central role of RTA in reactivation of Kaposi’s sarcoma-associated herpesvirus (KSHV) from latency leading to lytic cycle (2017, Human gammaherpesvirus 8)
• Misregulated expression of members of the ubiquitin cascade contributes to the aberrant signaling of various pathways in cancer (2017, Homo sapiens,Mus musculus,NA)
• Mechanism of action of GEMs (2017, Allium cepa)
• Lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement (2017, Homo sapiens,Mus musculus,Escherichia coli)
• SPARC overexpression alters microRNA expression profiles involved in tumor progression (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Sequoia sempervirens)
• Inositol polyphosphates synthetic pathway (2017, NA)
• Schematic model for ZJW extracts in inhibiting 5-HTR1D and attenuating Wnt/Beta-catenin signaling pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Lareunionomyces loeiensis,herbal medicine,Tetradium ruticarpum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway (2017, NA)
• Diagram depicting epinecidin-1-mediated degradation of MyD88a and downstream events (2017, Escherichia coli,Staphylococcus aureus,Enterococcus faecalis,Aggregatibacter actinomycetemcomitans,Escherichia coli O111B4,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Epinephelus coioides,Human adenovirus D37)
• Biosynthesis of ceramide, sphingosine-1-phosphate, and ceramide-1-phosphate (a) (2017, NA)
• Effects induced by l-dopa in the striatal MSNs of the direct pathway (2017, Armoracia rusticana,Syzygium aromaticum,Paeonia lactiflora,Gardenia jasminoides,Ligusticum sinense,Paeonia suffruticosa,Pogostemon cablin,Angelica gigas,Bupleurum falcatum,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Prevotella sp.,Porzana carolina)
• Proposed mechanisms of pathogenesis in haploinsufficiency of A20 (HA20), otulipenia/otulin-related autoinflammatory syndrome (ORAS), and linear ubiquitin chain assembly complex (LUBAC) deficiencies (2017, Homo sapiens,Mus musculus,NA)
• The pathway proposed in this study (2017, NA)
• Phosphopeptides from the MOE and FOE phosphoproteomes are represented in some distinct signaling pathways, including Rho signaling for MOE (A), GABA signaling for FOE (B) and amyloid processing for FOE (C) (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Lareunionomyces loeiensis)
• Schematic depicting the metabolic regulation of the mammalian Hippo signaling pathway (2017, NA)
• Molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism (2017, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Bubalus bubalis,Myotis lucifugus,Echinops telfairi,Ochotona dauurica,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Mesocricetus auratus,Phodopus sungorus,Dicrostonyx groenlandicus,Homo sapiens,Pan troglodytes,Otolemur garnettii,Saccharomyces cerevisiae,Arabidopsis thaliana,Escherichia coli)
• Schematic depicting the hormonal regulation of the mammalian Hippo signaling pathway (2017, NA)
• The core elements of the mammalian Hippo signaling pathway (2017, NA)
• Canonical pathway and upstream regulator effects analysis identifies inflammatory response, migration, and proliferation pathways enriched in trkB.T1 KO astrocytes (2017, NA)
• GnRH signaling pathway containing PLCB1 and MAP2K6 (2017, NA)
• High-Throughput Sequencing and Co-Expression Network Analysis of lncRNAs and mRNAs in Early Brain Injury Following Experimental Subarachnoid Haemorrhage (2017, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• The autophagy pathway and core autophagy proteins (2017, NA)
• Although a myriad of intracellular signaling is involved in passive therapies, their pathways show some overlap (2017, NA)
• Cellular mechanisms of radioresistance: (I) the cell cycle checkpoint signaling pathway is a critical progress that allowing times for cells to response to repair DNA damage (2017, Homo sapiens)
• mTORC1 and mTORC2 in cancer and the tumor microenvironment (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Major in vivo approaches for tolerance induction and suppression of inhibitor formation in hemophilia (2017, Homo sapiens,Mus musculus,Nicotiana tabacum,Canis lupus familiaris)
• Comparative expression profiling of testis-enriched genes regulated during the development of spermatogonial cells (2017, NA)
• Signaling involving TLR2 and TLR4 in strenuous and moderate aerobic exercise (2017, NA)
• Cancer Transcriptome Dataset Analysis: Comparing Methods of Pathway and Gene Regulatory Network-Based Cluster Identification (2017, NA)
• REACTOME diagrams of the type 1 interferon signaling pathway with highlighted and regulated proteins from the in vivo and in vitro experiments (2017, NA)
• Network analysis for the RS fraction proteins with increased secretion upon intracellular LPS stimulation (2017, NA)
• Protein interactions during the flavivirus life cycle elucidated by MS-based proteomics (2017, Dengue virus,Zika virus,West Nile virus,Japanese encephalitis virus,Yellow fever virus,Tick-borne encephalitis virus,Homo sapiens,NA)
• Tax activation of AP-1 pathway (2017, Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Human T-cell lymphotropic virus,Avian sarcoma virus 17,Homo sapiens,Mus musculus,Nicotiana tabacum)
• Transcriptional and post-translational activation of AP-1 (2017, Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Human T-cell lymphotropic virus,Avian sarcoma virus 17,Homo sapiens,Mus musculus,Nicotiana tabacum)
• Schematic model of NKILA functions during the invasion-metastasis cascade in NSCLC (2017, NA)
• Cartoon of Wnt signaling pathway contributed by (2017, Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/Beta-catenin signaling pathway (2017, NA)
• Atorvastatin inhibits the immediate-early response gene EGR1 and improves the functional pro of CD4+T-lymphocytes in acute coronary syndromes (2017, NA)
• Influence diagram of is a naive Bayes model that contains minimal prior biological knowledge (2017, Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• TGFB signaling pathway: at the blood-brain barrier, TGFB signaling is mediated by 2 distinct receptors designated activin receptor–like kinase 1 (ALK-1) and ALK-5 (2017, NA)
• Interplay between autophagy, apoptosis, and the stimulator of interferon genes (STING) pathway (2017, Human alphaherpesvirus 1,Human betaherpesvirus 5,Homo sapiens,Saccharomyces cerevisiae,Mycobacterium tuberculosis,synthetic construct)
• KEGG Ras signaling pathway with targetable nodes highlighted in red (2017, NA)
• GHRP mechanism of action (2017, NA)
• The immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity (2017, NA)
• Cisplatin or LA-12 enhance killing effects of TRAIL in prostate cancer cells through Bid-dependent stimulation of mitochondrial apoptotic pathway but not caspase-10 (2017, NA)
• Schematic representing the in-depth molecular mechanism of the neuroprotective effect of DZ (2017, Armoracia rusticana,Glycine max,Trifolium pratense,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2 (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• And Akt‐ion! IQGAP1 in control of signaling pathways (2017, NA)
• Wnt Signaling and Colorectal Cancer (2017, NA)
• Late gestational intermittent hypoxia induces metabolic and epigenetic changes in male adult offspring mice (2017, Mus musculus,Homo sapiens)
• Lysophosphatidic acid‐induced itch is mediated by signalling of LPA5 receptor, phospholipase D and TRPA1/TRPV1 (2017, NA)
• Structure of SCF/c-KIT proteins and downstream signalling pathways (2017, NA)
• Notch signaling pathways are shown mainly above (2017, Mus musculus,Rattus norvegicus,Momordica charantia,Candida albicans 11C,Homo sapiens)
• AMPK and JNK signaling pathways are shown above (2017, Mus musculus,Rattus norvegicus,Momordica charantia,Candida albicans 11C,Homo sapiens)
• Metabolic switch between MEP and MEC (2017, Zea mays)
• KEGG TGF-beta signalling pathway (2017, NA)
• The signaling pathway involved in the effect of FTY720P on the activity of the Na+/K+ ATPase (2017, NA)
• Interaction between AMPK and AKT on the phosphorylation: Growth factor activates TKR and promotes the activation of AKT via IRS1/PI3K/PDK1 signaling (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of Fn expression in macrophages after S (2017, Staphylococcus aureus,Homo sapiens)
• Neuroinflammation pathway and therapeutic modules (2017, NA)
• Regulatory signaling of osteocyte phenotypes mediated by extracellular DMP1 (2017, NA)
• PRIP regulates thermogenesis in brown adipocytes (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Staphylococcus aureus,Antarctothoa delta)
• C-T-P network (2017, NA)
• Two major pathways in the cellular folate cycle (2017, NA)
• Molecular mechanisms of the attenuation of PI3K and Akt, and the dysregulation of PI3K/Akt signaling pathway by gingipains (2017, NA)
• Action of Coxiella burnetii effectors inferred from host-pathogen protein interactions (2017, Coxiella burnetii,Homo sapiens)
• Structure of (A) HGF and (B) Met (2017, NA)
• Host-Helminth interaction: There are two sides of immune response against a parasite invasion, one leads to worm survival in host and the other to worm killing (2017, Caenorhabditis elegans,Schistosoma mansoni,Ciona intestinalis,Fasciola hepatica,Schistosoma japonicum,Ascaris suum,Clonorchis sinensis,Trichinella spiralis,Brugia malayi,Schistosoma haematobium,Echinococcus multilocularis,Echinococcus granulosus,Ascaris lumbricoides,Taenia solium,Bursaphelenchus xylophilus,Globodera pallida,Mesocestoides corti,Fasciola gigantica,Angiostrongylus cantonensis,Fasciolopsis buski,Eurytrema pancreaticum,Echinococcus canadensis,Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Gallus gallus,Synodontis clarias,Homo sapiens,clinical samples)
• Downstream signaling pathway of cytokines sharing the common G chain receptor: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 (2017, NA)
• Interaction of HER-activated pathways with canonical Wnt signaling (2017, NA)
• Release of growth hormone (GH), Wnt, or RANKL, as stimulated by progesterone (P4), promotes interaction with various signal transduction pathways (2017, NA)
• Synthetic diagram of opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in cancer (2017, NA)
• Schema of interactions between the canonical WNT/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in cancer (2017, NA)
• Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans (2017, Caenorhabditis elegans,Homo sapiens)
• let-7c is predicted to target the RAS signaling pathway and miR-98 (2017, Homo sapiens,Mus musculus,Middle East respiratory syndrome-related coronavirus)
• Schematic model of the inhibition of the VEGF/VEGFR signaling pathway in HCC cells by BD0801 (2017, NA)
• Multiple signaling pathways drive EMT in GBC cells (2017, NA)
• Regulation of Akt signaling pathways after (A) vehicle, and (B) melatonin treatments following ischemic-stroke (2017, NA)
• An integrated network for phenylpropanoid regulation in the grape berry (2017, Arabidopsis thaliana,Solanum lycopersicum,Vitis vinifera,Homo sapiens,Octodon degus,Cilus gilberti)
• Gene networks associated with intestinal processes and diseases (2017, NA)
• Proposed schematic representation showing mechanism of action of carbofuran and its effect on neurogenesis (2017, NA)
• Simplified schematic of the possible mechanism of lymphangiogenesis in cancer cell metastasis (2017, NA)
• Enriched canonical pathway for RIG-I like receptor signaling at 48 hps with dsRNA (2017, NA)
• Enriched canonical pathway for toll-like receptor signaling at 48 hps with dsRNA (2017, NA)
• Hedgehog signaling pathway (2017, NA)
• Schematic picture of the oxLDL regulation of MCP‐1 release, and the mechanism of the regulatory effect of oxLDL antibody (2017, NA)
• MSCs secretome and tumor stemness (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Predicted positions of the directly connected nodes and connected cytochrome nodes on the glucosinolate metabolic pathway (2017, NA)
• Regulation of hormone synthesis, signaling and transport in seeds by histone deacetylation (2017, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Embryophyta,Triticum aestivum,Hordeum vulgare,Marchantiophyta,Homo sapiens)
• Immunometabolic regulations mediated by coinhibitory receptors in innate immune cells and cancer can impact T cell immune responses (2017, Human alphaherpesvirus 1,Enterovirus C,Homo sapiens,Mus musculus,NA,NA)
• Upon antigen encounter T cells differentiate into effector cells (2017, Human alphaherpesvirus 1,Enterovirus C,Homo sapiens,Mus musculus,NA,NA)
• Signaling Pathways Controlling Microglia Chemotaxis (2017, NA)
• Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells (2017, Homo sapiens,Mus musculus,Bos taurus)
• Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin (2017, NA)
• Scheme depicting a molecular pathway by which Cdc25A is induced/activated and promotes neuron death in disease and development (2017, NA)
• Gas6 and TAM receptor signalling (2017, Mus musculus,Rattus norvegicus,Avian retrovirus,Avian retrovirus RPL30,Homo sapiens,Gallus gallus,Corynebacterium phage gamma)
• ATG5-ATG12 involvement in FMDV-induced type IIFN signal pathway (2017, NA)
• Working model summarizing the role of Survivin in adipocyte homeostasis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Schematic diagram showing the mechanisms of action of cordycepin based on the findings of this study (2017, NA)
• Cell migration induced by EGF via regulated alternative splicing of the Rho GTPase Rac1 (2017, NA)
• Major pathways associated with pancreatic ductal adenocarcinoma and site of action of current treatments (2017, NA)
• HMGB1 release regulated by the PLCG1–IP3R–SOC signalling pathway during calcium overload in hepatocytes (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Ophiopogon japonicus,Homo sapiens)
• Apoptotic Pathways in Glioblastoma (2017, NA)
• Genomic alterations in malignant melanoma (2017, Homo sapiens,Saccharomyces cerevisiae)
• Diagram of glycolysis is shown, including enzymes whose transcripts were more highly expressed in GRMD (red) or wild type dogs (green) (2017, NA)
• Physiological development-functions associated with the dorsal hippocampus and nucleus accumbens of ENT1−/− mice (2017, Sequoia sempervirens,Bikinia letestui,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens)
• Differential expression of proteins in the nucleus accumbens generates specific network interactomes in ENT1−/− mice (2017, Sequoia sempervirens,Bikinia letestui,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens)
• Differential expression of proteins in the dorsal hippocampus generates specific network interactomes in ENT1−/− mice (2017, Sequoia sempervirens,Bikinia letestui,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens)
• Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome (2017, NA)
• Overview of human TLRs activated by exogenous and endogenous ligands, such as fragmented DNA from necrotic cells; adapted by permission from Macmillan Publishers Ltd, Nature Reviews Gastroenterology and Hepatology, 2006, vol (2017, Allium sativum,Ginkgo biloba,Zingiber officinale,Andrographis paniculata,Mus musculus,Rattus norvegicus,Cavia porcellus,Pseudomonas aeruginosa,Pseudomonas aeruginosa BL10,Homo sapiens,Danio rerio,NA)
• Siglec-G/10 in the immune regulation of sepsis (2017, NA)
• The PTHLH/PTH1R-ATF2 negative-feedback loop (2017, NA)
• Possible roles of Mgs1 and WRNIP1 in DNA transaction (2017, Escherichia coli,Helicobacter pylori,Escherichia coli FBH1,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• Antioxidant effect of Baccharis trimera (2017, NA)
• Functions and its signaling pathways of Panx3 in osteoblast differentiation (2017, Mus musculus,Homo sapiens)
• Adaptive resistance and innate resistance (2017, NA)
• Regulatory roles of Gsdma3/GSDMA in autophagy or apoptosis (2017, Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Priestia megaterium,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Schematic of the DNA repair pathway (2017, NA)
• tmTNF-Alpha-induced STAT1-dependent apoptotic signaling via TNFR1 (2017, NA)
• Integrated proteomic analysis of Brachypodium distachyon roots and leaves reveals a synergistic network in the response to drought stress and recovery (2017, NA)
• Depiction of RAS-ERK signaling pathway and primary and secondary connections to substrates identified by time-resolved phosphoproteome profiling (2017, NA)
• Cross talk between immunoreceptor tyrosine-based activation motif (ITAM)-associated receptor signaling and toll-like receptor (TLR) pathways in conventional dendritic cells (cDCs), MΦ, and plasmacytoid DCs (pDCs): an ITAM-centric view (2017, NA)
• Low-avidity signaling of B2-integrin regulates toll-like receptors (TLR) signaling in macrophages (2017, NA)
• Proposed model of organization of small airways (2017, NA)
• IRS4 signaling in malignant cells and therapy resistance (2017, NA)
• Two arms of the insulin signaling pathway in skeletal muscle cells (2017, NA)
• Cytosolic co-delivery of miRNA-34a and docetaxel with core-shell nanocarriers via caveolae-mediated pathway for the treatment of metastatic breast cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Signaling pathways involved in CORM-3-induced HO-1 expression and protected against IL-1Beta-induced cell migration in RBA-1 cells (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Japanese encephalitis virus)
• Screening the active compounds of Phellodendri Amurensis cortex for treating prostate cancer by high-throughput chinmedomics (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,herbal medicine,Eleutherococcus senticosus,Phellodendron amurense,Mus musculus,Rattus norvegicus,H4N4 subtype,Turkey rhinotracheitis virus,Homo sapiens,NA)
• Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the PI3K-Akt signalling pathway (KEGG ecb04151) (2017, NA)
• Significantly up-regulated genes during analysed training periods in Arabian horse blood that belong to the FoxO signalling pathway (KEGG ecb04068) (2017, NA)
• Fish retinoic acid‐inducible gene I (RIG‐I) ‐like receptor (RLR) ‐mediated signalling pathways in response to viral and bacterial infections (2017, Danio rerio,teleost fish,Edwardsiella tarda,Homo sapiens)
• Biosynthesis of anthocyanins, flavonols and catechins via the flavonoid pathway in Rubus spp (2017, Arabidopsis thaliana,Glycine max,Malus domestica,Camellia sinensis,Fragaria x ananassa,Medicago sativa,Musa acuminata,Picea abies,Vigna unguiculata,Vaccinium myrtillus,Fragaria vesca,Citrus unshiu,Rubus occidentalis,Penicillium digitatum,Lonicera caerulea,Sesbania grandiflora,Fragaria vesca subsp. vesca,Pinus ponderosa,Pinus ponderosa var. ponderosa,Homo sapiens,Pseudomonas fluorescens)
• Molecular mechanisms involved in induction and progression of podocyte EMT caused by hyperglycemia (2017, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Lareunionomyces loeiensis)
• Biosynthetic pathway of O-glycans (2017, NA)
• Signal transduction in melanoma with regard to the role of the SOX10-MITF pathway (2017, NA)
• Metabolic scheme of targeted oxylipins (2017, NA)
• NFKB pathway.Notes: (A) The canonical pathway starts with binding of TNF to its receptor, activating the IKK complex, which phosphorylates IKBA, promoting its polyubiquitination and further proteasome-dependent degradation (2017, NA)
• Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Human papillomavirus type 16,Bikinia letestui,Papaya ringspot virus,Homo sapiens,Mus musculus,vectors)
• Wnt pathways.Notes: (A) Planar cell polarity (PCP) Wnt pathway in “off” state, with no ligand bound to Fzd receptor leads to Beta-catenin proteasome degradation (2017, NA)
• PI3K signaling pathway.Notes: (A) Activation of receptor tyrosine kinase (RTK) by a ligand results in phosphorylation of the receptor and adaptor proteins (2017, NA)
• The crossroads of breast cancer progression: insights into the modulation of major signaling pathways (2017, NA)
• Schematic presentation of signaling mechanisms for the neuroprotective effects of NGR1 (2017, NA)
• The hypothetical signalling pathway leading to endothelium-dependent dilation in static versus pulsatile pressure conditions (2017, Mus musculus,Homo sapiens)
• Roles of PFKFB3 in different cancer cells (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• MiR-93 activates the PI3K/Akt pathway by targeting LKB1/PTEN/p21 (2017, NA)
• Proposed mechanism by which B7-H3 promotes the migration and invasion of bladder cancer cells (2017, NA)
• Cancer immunotherapies targeting the PD-1 signaling pathway (2017, NA)
• TRIM38-mediated negative regulation of TLR3/4-mediated and TNF/IL-1-triggered signaling (2017, DNA viruses)
• Proposed model for activation of IFN by doxorubicin bypassing IFN antagonism by Ebola virus VP35 protein (2017, NA)
• Ethanol-induced decrease in Alpha-MSH drive and its impact on glial inflammation and hemichannel/pannexon-dependent gliotransmission (2017, Nicotiana tabacum)
• Signaling pathways involving PFKFB3 (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• PD-L1 upregulation in response to DNA double-strand breaks (2017, Homo sapiens,Mus musculus,Bos taurus,Dipturus trachyderma)
• Breast cancer pathway(red, up-regulated) (2017, NA)
• Parkinson disease pathway(red, up-regulated) (2017, NA)
• Ursodeoxycholic acid (UDCA)-induced apoptosis in DU145 human prostate cancer cells (2017, NA)
• Related cell process and diseases with potential disease biomarkers induced by particulate matter visualized by Pathway Studio (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Nicotiana tabacum,H1N1 subtype,Cellulosimicrobium cellulans)
• Predicted PHS degradation pathway (2017, NA)
• DHS and PHS metabolic pathways (2017, NA)
• Model whereby both uracil glycosylases and the Pms2/Mlh1 complex enable A-T base pair mutagenesis with a distinct strand bias (2017, NA)
• Six genes are enriched in the top 2 significant pathways(red, up-regulated) (2017, NA)
• Wnt signaling pathway pathway(red, up-regulated) (2017, NA)
• Crosstalk between signals initiated from TLR4 and cell surface BAFF results in synergistic induction of proinflammatory mediators in THP-1 cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,Human T-cell leukemia virus type I)
• Proteogenomic integration reveals therapeutic targets in breast cancer xenografts (2017, Homo sapiens,Mus musculus)
• Transcriptome analysis of Corynebacterium glutamicum in the process of recombinant protein expression in bioreactors (2017, NA)
• All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Proposed model of how MUC1 promotes the progression and tumorigenesis of HCC and the targeted therapies in preclinical and clinical trials (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• A hypothetical mechanism for the anti‐tumor effects of verteporfin in pancreatic ductal adenocarcinoma (PDAC) cells (2017, Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,vectors)
• Plant-parasitic nematodes: towards understanding molecular players in stress responses (2017, NA)
• Regulation of cellular senescence by transforming growth factor B (TGFB) signaling (2017, NA)
• Transforming growth factor B (TGFB) signaling pathway and its context-dependent regulation (2017, NA)
• Conceptual framework of CDKN2A expression during persistent LPS senescence induction (2017, NA)
• Regulatory network construction for the overlapped genes (2017, NA)
• Proposed model demonstrating a possible mechanism for BAY to intervene in the TGFB signalling pathway in renal fibrosis (2017, NA)
• Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133 (2017, Mus musculus,Rattus norvegicus,Danio rerio,Corvus corax,Homo sapiens,Bos taurus,Escherichia coli,Hepatitis B virus,NA)
• Emerging signaling pathways in HCC: chromatin remodeling: restricting transcriptional and DNA condensation occurs as a result of histone deacetylation catalyzed by HDACs in nucleosome (2017, NA)
• Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway (2017, NA)
• Predicted mechanism by which chloroquine kills the malaria parasite (2017, Plasmodium falciparum,Homo sapiens)
• Cell cycle pathway(red, up-regulated) (2017, NA)
• Apoptosis pathway(red, up-regulated) (2017, NA)
• Thyroid hormones pathway (red, up-regulated) (2017, NA)
• The Wnt-IFN signaling intersection (2017, NA)
• Sonic hedgehog signaling pathway (2017, NA)
• Non-canonical Shh signaling in commissural axon guidance (2017, NA)
• The autophagy pathway (2017, NA)
• Proposed pathway of TGFB2–TLR4 signaling crosstalk in the glaucomatous TM (2017, NA)
• Schematic summary of genetic abnormalities in ATL cells (2017, Human T-cell leukemia virus type I)
• Survival and proliferative effects of AOF extract on RSC96 Schwann cell (2017, NA)
• Molecular signaling involved in nephrogenesis (2017, Homo sapiens)
• Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Ostreococcus tauri,Homo sapiens,Bos taurus,Drosophila melanogaster,Human immunodeficiency virus 1,Xenopus laevis)
• Relationships among miRNAs and canonical Wnt signaling, metastasis, and tumor-initiating cells (2017, NA)
• Genes frequently mutated in colorectal cancer and their relationships with miRNAs (2017, NA)
• Step-wise tumorigenesis in colorectal cancer (2017, NA)
• Type I interferons (IFNs) and different other cytokines are essential for natural killer (NK) cell homeostasis and function (2017, NA)
• Bio-chemical pathway of UBE2D4 and its role in cancer progression (2017, NA)
• Simple diagrammatic representation of the (known) key events in Shh signaling at the primary cilium (2017, NA)
• Proteomic characterization of epicardial-myocardial signaling reveals novel regulatory networks including a role for NFKB in epicardial EMT (2017, NA)
• Immediate immune responses of pulmonary resident cells to RSV infection in neonates (2017, Mus musculus,Rattus norvegicus,Lacticaseibacillus rhamnosus,Escherichia coli K1,Sigmodon hispidus,Lacticaseibacillus rhamnosus CRL1505,Homo sapiens,Respiratory syncytial virus,Pan troglodytes,Human orthopneumovirus,Capra hircus,Dermatophagoides farinae,Scardinius erythrophthalmus)
• NFKB signaling pathway is activated by TLR3/TLR4 (2017, NA)
• Regulatory networks that control intrarenal RAS activity (2017, NA)
• Activation of the RAS/ERK and phosphoinositide cell signaling pathways following the binding of cell survival signals to receptor tyrosine kinases (RTK) (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Mouse mammary tumor virus)
• Schematic representation of the general phenylpropanoid pathway leading to major branches of flavonoid biosynthesis and their possible interaction with miRNAs (2017, NA)
• Pathway for synthesis of ceramide, sphingomyelin, and sphingosine-1 phosphate (2017, NA)
• Effect of chronic alcohol intake on mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in white adipose tissue from mice (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Scapteromys aquaticus,Candida dubliniensis,Linum usitatissimum,Homo sapiens)
• Lipolytic and lipogenic pathways in white adipose tissue (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Scapteromys aquaticus,Candida dubliniensis,Linum usitatissimum,Homo sapiens)
• Localization of Moco biosynthesis, FeS cluster biosynthesis and tRNA thiolation in humans (2017, Escherichia coli,Thermus thermophilus,Pyrococcus furiosus,Aquifex aeolicus,Haloferax volcanii,Saccharomyces cerevisiae,Arabidopsis thaliana,Agriosomyces longus,Homo sapiens,Mus musculus,Hypsophrys nicaraguensis)
• Modulators and signaling pathway of group I mGluRs (2017, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Homo sapiens,Bos taurus,Xenopus laevis,Rubella virus)
• Mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway (2017, NA)
• RAS/RAF/MEK aberrant signaling and mechanisms of resistance to inhibition in melanoma (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Human immunodeficiency virus 1)
• Interaction and localization of proteins, belonging to the angiopoietin signaling pathway and found in samples 2 and/or 3 (2017, NA)
• Interaction and localization of proteins belonging to the integrin signaling pathway and found in samples 2 and/or 3 (2017, NA)
• Schematic summarizing how ANE decreases cisplatin toxicity in OSCC cells by inducing autophagy, and that the ROS and AMPK/mTOR pathways were involved in this process (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Areca catechu)
• Nerve growth factor (NGF) and its Tyrosine Kinase A receptor (TRKA) are involved in several signaling pathways in epithelial ovarian cancer (EOC) (2017, NA)
• Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus (2017, NA)
• Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus (2017, NA)
• Phospho-sites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT signaling pathway in a lung adenocarcinoma cell line harboring a L858R mutation in the kinase domain of EGFR, which is reactive to treatment with erlotinib (2017, NA)
• KEGG pathway hsa05200 “Pathways in cancer” (2017, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Cladophora subtilissima,Homo sapiens,Gallus gallus)
• Schematic metabolic model showing important pathways after proliferation of Streptococcus suis serotype 2 in porcine blood (A) and cerebrospinal fluid (CSF) (B) (2017, Streptococcus suis,Homo sapiens)
• Outer membrane protein-mediated pathogenesis (2017, Helicobacter pylori,Homo sapiens)
• Non-Canonical Roles of Dengue Virus Non-Structural Proteins (2017, Dengue virus,Vaccinia virus,Zika virus,West Nile virus,Japanese encephalitis virus,Yellow fever virus,Dengue virus type 2,dengue virus type I,Kunjin virus,Bamboo mosaic virus,Yellow fever virus group,Homo sapiens,Mus musculus,NA)
• Scheme describing potential roles of AOX and COX metabolism in arbuscular mycorrhizal fungi (2017, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Olea europaea,Aspergillus fumigatus,Sorghum bicolor,Magnoliopsida,Medicago truncatula,Helianthus annuus,Allium cepa,Daucus carota,Pisum sativum,Aspergillus niger,Phaseolus vulgaris,Neurospora crassa,Solanum melongena,Beta vulgaris subsp. vulgaris,Linum usitatissimum,Petunia x hybrida,Lotus japonicus,Sclerotinia sclerotiorum,Trifolium pratense,Trifolium repens,Betula pendula,Metarhizium anisopliae,Funneliformis mosseae,Rhizophagus intraradices,Rhizophagus irregularis,Moniliophthora perniciosa,Gigaspora gigantea,Chromolaena odorata,Amylomyces rouxii,Gigaspora rosea,Glomus sp.,Diversispora versiformis,Rhizophagus irregularis DAOM 181602DAOM 197198,Hymenachne hemitomon,Endogone sp.,Dictyostelium discoideum,Pseudomonas syringae pv. tomato,NA,Homo sapiens)
• Differential functions of different isoforms of NKp30 and NKp44 (2017, Human immunodeficiency virus 1,unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Vaccinia virus,Dengue virus group,Swine influenza virus,Ectromelia virus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mus musculus,Rattus norvegicus,Homo sapiens,Plasmodium falciparum,NA)
• Mechanism of signaling transduction of vascular permeability (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model that Alpha-MSH activates mTORC1 and protects against H2O2-Induced loss of dendrites in human skin melanocytes (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Bikinia letestui)
• The proposed mechanism of BBB disruption in CNS TB (2017, NA)
• Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/ p21WAF1/CIP1 and p27KIP1 pathway (2017, NA)
• Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Raphanus sativus)
• Comparative transcriptomic analysis of mice liver treated with different AMPK activators in a mice model of atherosclerosis (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Raphanus sativus)
• HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo (2017, Mus musculus,Rattus norvegicus,Bos taurus,Homotherium serum,Homo sapiens,bacterium NOTE)
• Sub-lethal oxidative stress induces lysosome biogenesis via a lysosomal membrane permeabilization-cathepsin-caspase 3-transcription factor EB-dependent pathway (2017, NA)
• Summary of detected genes associated with the MTX toxicity in RA patients in previous studies (2017, Homo sapiens,Bathymaster signatus)
• Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/Beta-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease (2017, NA)
• Pediatric Ependymoma: A Proteomics Perspective (2017, NA)
• STAT-5-dependent activation of ATM and ATR pathways, required for HPV genome amplificationHigh-risk HPV activates STAT-5 to mediate TopBP1 transcriptionally to promote ATR pathway (2017, Homo sapiens)
• Signaling pathways of ATM and ATRThe DNA damage response is activated by ATM, ATR, and DNA-PKcs (2017, Homo sapiens)
• Physiological functions of PD-related Rabs (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,prion)
• Metabolic pathway of clopidogrel and its targeted receptor (2017, Homo sapiens,Canis lupus familiaris)
• Pro-inflammatory response through TLR: various antigenic molecules are recognized differentially by TLRs, which produce pro-inflammatory responses (2017, Plasmodium falciparum,Leishmania donovani,Plasmodium berghei,Plasmodium yoelii,Plasmodium chabaudi,Homo sapiens,Mus musculus,Candida dubliniensis,Pseudomonas aeruginosa,Paracheirodon innesi)
• Alterations in histone methylation in pediatric and adult high-grade glioma (2017, Homo sapiens,Mus musculus,Diaporthe sclerotioides,unidentified)
• Transcriptional networks that regulate LIN28B expression (2017, NA)
• LIN28A/ZCCHC11 regulation of let-7 microRNA biogenesis, promoting cellular proliferation and modifying bioenergetics (2017, NA)
• Proposed working model (2017, Helicobacter pylori,Homo sapiens)
• Nanotechnology-based therapy for prostate cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• Wnt signaling pathway and targets of small‐molecule inhibitors (2017, NA)
• Autotrophic product formation in C (2017, Clostridium autoethanogenum,Homo sapiens)
• Diagrammatic scheme depicting potential survival pathway-related gene targets of the downregulated microRNAs and their signaling pathways in prostate cancer cells (2017, NA)
• Diagrammatic scheme depicting targeted p53 pathway-related genes by upregulated miRNAs in prostate tumor cells (2017, NA)
• Model depicting role of miR-432 in regulating myogenesis (2017, NA)
• Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients (2017, NA)
• PDK1 contributes to polarization of signaling downstream to PI3K during cell migration (2017, Homo sapiens,Mus musculus,Danio rerio,Dictyostelium discoideum,Corynebacterium phage gamma)
• Phosphatidylinositol-3-kinase (PI3K)–3-phosphoinositide-dependent protein kinase-1 (PDK1) pathway (2017, Homo sapiens,Mus musculus,Danio rerio,Dictyostelium discoideum,Corynebacterium phage gamma)
• Drug targets in AR signaling pathway (2017, NA)
• Suggested signaling pathways for induction of the immunosuppressive catabolic enzyme indoleamine 2,3-dioxygenase (IDO1) in vertebrate dendritic cells (DCs) (2017, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Vibrio cholerae,NA)
• Representative view of the iNKT/innate CD8(+) T-cell axis hypothesis in chronic myeloid leukemia (CML) (2017, NA)
• Cartoon illustrating a novel signaling pathway for the coordinated regulation of Rho and Rac signaling in epithelial invasion (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,vectors)
• Relationship between the nine DEGs in network 1 in the Jerseys (2017, Glycine max,Lareunionomyces loeiensis,Hordeum vulgare,Sequoia sempervirens,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Gallus gallus)
• Relationship between 18 DEGs in network 1 in the Holsteins (2017, Glycine max,Lareunionomyces loeiensis,Hordeum vulgare,Sequoia sempervirens,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Gallus gallus)
• Regulation of PI3K signaling in T cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD (2017, NA)
• Paradoxical Role of High Mobility Group Box 1 in Glioma: A Suppressor or a Promoter? (2017, NA)
• Notch gene signaling pathway interactions (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus,Middle East respiratory syndrome-related coronavirus)
• Serum microRNA profiling and bioinformatics analysis of patients with type 2 diabetes mellitus in a Chinese population (2017, NA)
• Acceleration of bone regeneration by activating Wnt/Beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Putative transcription factor network for estrogen signaling (2017, NA)
• Shigella modulates the innate immune response in epithelial cells (2017, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Salmonella enterica subsp. enterica serovar Typhi,Shigella dysenteriae,Shigella sonnei,Shigella boydii,Shigella flexneri 2a,Plesiomonas shigelloides,Shigella flexneri 5a,Plasmid pWR100,Mus musculus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus,Bikinia letestui,Calloplesiops altivelis)
• Bile acid synthesis, signaling, and regulation in human liver (2017, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome)
• CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy (2017, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• The Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt (2017, NA)
• Simplified scheme of the PI3K/AKT/mTOR signaling pathway (2017, Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pyogenes,Proteus vulgaris,H9N3 subtype,H11N3 subtype,Homo sapiens,Mus musculus,Bos taurus)
• Meta-network illustrating synergistic interventions and resistance mechanisms to PI3K inhibitors (2017, NA)
• Proposed mandelalide biosynthetic pathway (2017, NA)
• Top Network Associated with the DERs Selected by the Criteria of 4-fold Change in Whole BloodThe functions related to this network are defined as cancer, organismal injury and abnormalities, and reproductive system disease (2017, NA)
• Proposed role of RUNDC3B in the MAPK signalling pathway (2017, NA)
• Current StudyIn the AD brain, HDAC2 is upregulated and induces the deacetylation of the HNF-4A transcription factor, which leads to the inhibition of HNF-4A and the suppression of miR-101b expression (2017, NA)
• Exploration of small RNA-seq data for small non-coding RNAs in Human Colorectal Cancer (2017, NA)
• MyomiR interaction with Akt-mTORC1 signaling pathway (2017, NA)
• Possible interplay between insulin-like growth factor (IGF)-1 and vascular endothelial growth factor (VEGF) receptor signaling pathways (2017, Gallus gallus,Dipturus trachyderma,Uria aalge,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Vicia sativa)
• Suggested model (2017, NA)
• Hippo signaling pathway provides novel anti-cancer drug targets (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Hippo signaling pathway provides novel anti-cancer drug targets (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Long non-coding RNAs in nasopharyngeal carcinoma: As systemic review (2017, NA)
• Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Human papillomavirus,Mycobacterium tuberculosis variant bovis BCG,Theobroma cacao,NA)
• Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NFKB in vitro (2017, Bos taurus,Oryctolagus cuniculus,Bison bonasus,Homo sapiens,Mus musculus,Armoracia rusticana,Helicobacter pylori)
• LncSubpathway: a novel approach for identifying dysfunctional subpathways associated with risk lncRNAs by integrating lncRNA and mRNA expression profiles and pathway topologies (2017, Homo sapiens,Diaporthe sclerotioides)
• Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3Beta-involved Wnt/Beta-catenin pathway (2017, NA)
• Probing the prostate tumour microenvironment I: impact of glucose deprivation on a cell model of prostate cancer progression (2017, Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus,unidentified,Piromyces finnis)
• Cancer suppression by systemic inactivation of p38MAPK (2017, NA)
• Metabolic pathway of butanoate metabolism in Halomonas sp (2017, NA)
• TGFB receptor signaling is proposed to facilitate successful recovery from cellular damage by interacting with the Wnt-Beta-catenin pathway (2017, NA)
• Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells (2017, Gallus gallus,Danio rerio,Coturnix coturnix,Coturnix japonica,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Matthiola incana,Homo sapiens)
• Examples of functional networks of regulated genes shared by different tissues (2017, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Glycine max,Sequoia sempervirens,Homo sapiens,Gallus gallus,Porcine reproductive and respiratory syndrome virus,Pieris brassicae)
• Resveratrol fuels HER2 and ERAlpha-positive breast cancer behaving as proteasome inhibitor (2017, NA)
• Stress polarity pathway: AMPK ‘GIV’-es protection against metabolic insults (2017, NA)
• GIST and apoptosis signaling (2017, NA)
• Amyloid precursor protein (APP) processing.APP preferred processing is the non-amyloidogenic pathway which digests with Alpha-secretase followed Gamma-secretase and takes place at the plasma membrane (PM) (2017, NA)
• Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin (2017, NA)
• Early metabolic and transcriptional variations in fruit of natural white-fruited Fragaria vesca genotypes (2017, Fragaria vesca,Homo sapiens)
• Diagram summarizing the effects of effector proteins on inflammatory signaling pathways in host cells (2017, NA)
• Signalling Pathway of Mucositis (2017, Homo sapiens,Saccharomyces cerevisiae,Human alphaherpesvirus 1,Porphyromonas gingivalis,NA)
• Mechanism by which MMP-9 regulates formation of focal adhesion junctions (2017, Armoracia rusticana,H15N2 subtype,H13N2 subtype,Carex media,Cycas media subsp. media,H11N2 subtype,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Gallus gallus,Leptospira kmetyi,Parthenolecanium pruinosum)
• IFITM proteins are involved in various cellular processes with direct and indirect impacts on immunity (2017, NA)
• Stages of innate lymphoid cell (ILC) development (2017, NA)
• Perfluorocarbon reduces cell damage from blast injury by inhibiting signal paths of NFKB, MAPK and Bcl-2/Bax signaling pathway in A549 cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of the MAPKs/TGFB1/TRAF6 signaling pathway in postoperative atrial fibrillation (2017, Homo sapiens,Mus musculus,Armoracia rusticana,Canis lupus familiaris)
• Visualization of selected miRNA targeting events on the insulin signaling pathway (from WikiPathways) (2017, NA)
• List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C (2017, Sebastiscus marmoratus,Cryptocaryon irritans,Homo sapiens)
• List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S (2017, Sebastiscus marmoratus,Cryptocaryon irritans,Homo sapiens)
• Title: For UPR signaling pathway, PERK and IRE1 activate autophagy through endoplasmatic reticulum stress (2017, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus)
• Title: In PI3K-Akt-mTOR signaling pathway, PI3K inhibits autophagy via activation of Akt (2017, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus)
• Main signaling pathways involved in vasculogenic mimicry (2017, NA)
• List of genes involved in Toll-like receptor pathway generated by KEGG of the differently expressed genes between Cryptocaryon irritans-infected and non-infected S (2017, Sebastiscus marmoratus,Cryptocaryon irritans,Homo sapiens)
• Heterogeneity in Cancer Metabolism: New Concepts in an Old Field (2017, NA)
• Heterogeneity in Cancer Metabolism: New Concepts in an Old Field (2017, NA)
• Signalling mechanisms mediating Zn2+-induced TRPM2 channel activation and cell death in microglial cells (2017, NA)
• Gab2 regulation by the Ras/ERK pathway (2017, NA)
• Enrichment analysis for pathway map ontologies revealed significant biological processes associated with the most promising targets commonly deregulated in mouse and human ALS (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Schematic diagram showing the mechanism of action of NSAIDs like aspirin in inhibiting the metabolism of arachidonic acid by blockade of the cyclooxygenases (COX) pathway and the prostaglandins (PG) synthase pathway, thus suppressing PGs synthesis (2017, NA)
• ReactomeFIViz: from disease pathway to PPI network (2017, NA)
• List of genes involved in the complement and coagulation cascades pathway generated by KEGG of the differently expressed genes between C (2017, Sebastiscus marmoratus,Cryptocaryon irritans,Homo sapiens)
• Oncolytic virus mediated enhanced anti-tumoral immunity, including enhanced CAR T-cell recruitment and effector function (2017, NA)
• Osteogenic Wnt/Beta-catenin pathway and its interplay with polyphenols (2017, NA)
• Computational analysis of miR-155-5p target mRNAs and altered pathway—neurotrophin signaling pathway (2017, NA)
• Regulation of SphK1 signalling (2017, NA)
• Layered network between muromonab and myasthenia gravis (MG) (2017, NA)
• Layered network between sunitinib and myasthenia gravis (MG) (2017, NA)
• Layered network between adalimumab and MG (2017, NA)
• Layered network between rituximab and myasthenia gravis (MG) (2017, NA)
• Identifying myasthenia gravis (MG) risk genes regulated by drugs and miRNAs in the hsa05200 pathway (2017, NA)
• Cellular localization of the autophagy genes regulated by 1,25(OH)2D3 (Ingenuity Pathway Analysis software) in MCF-7 cells (2017, NA)
• Crosstalk between inflammation and thrombosis (2017, NA)
• RhoG function in invadopodia (2017, Homo sapiens)
• Upregulation of skeletal muscle PGC-1A through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Saccharomyces cerevisiae,Glycine max,Citrus x paradisi,Cucurbita moschata,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• FcGRIIIb signaling to induce neutrophil extracellular trap (NET) formation (2017, NA)
• FcGRIIIb initiates signaling pathways to the nucleus (2017, NA)
• Currently tested pharmaceuticals targeting the Wnt pathway in cancer (2017, Drosophila melanogaster,Lareunionomyces loeiensis,Fasciola hepatica,Erythroxylum coca,Homo sapiens,Mus musculus,Xenopus laevis,Mouse mammary tumor virus)
• Canonical and non-canonical Wnt signaling (2017, Drosophila melanogaster,Lareunionomyces loeiensis,Fasciola hepatica,Erythroxylum coca,Homo sapiens,Mus musculus,Xenopus laevis,Mouse mammary tumor virus)
• Epidermal growth factor receptor (EGFR)–related signaling pathway in metastatic colorectal cancer (2017, Homo sapiens,Human gammaherpesvirus 4,clinical samples)
• Wnt, Hedgehog, and Notch canonical signaling pathways (2017, NA)
• Interactions of the AKT signaling pathway with the GSK3B signaling pathways (2017, NA)
• Cross talk of the Wnt/Beta-catenin pathway with the epidermal growth factor receptor (EGFR) and fibroblast growth factor (FGF) pathways in hepatitis C virus (HCV)-related hepatocellular carcinoma (2017, NA)
• Schematic overview of the proposed iOGN:TLR4 signaling pathway (2017, NA)
• Intracellular trafficking path for SORLA (2017, NA)
• tHGA blocked eosinophil-induced EMT by suppressing TGFB synthesis via JNK and PI3K pathway (2017, NA)
• Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation (2017, Mus musculus,Rattus norvegicus,Murine hepatitis virus,Murine hepatitis virus strain 3,Homo sapiens,Echinococcus multilocularis,NA,NA)
• Extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma (2017, NA)
• Immune cells in liver regeneration (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus,Listeria monocytogenes,Murid betaherpesvirus 1)
• Factors and pathways involved in capacitation: how are they regulated? (2017, Homo sapiens)
• Measurements of heterotypic associations between cluster of differentiation CD74 and CD44 in human breast cancer-derived cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus)
• Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm (2017, Homo sapiens)
• Identification of biomarker microRNAs for predicting the response of colorectal cancer to neoadjuvant chemoradiotherapy based on microRNA regulatory network (2017, Homo sapiens,Bos taurus,Armoracia rusticana)
• Na+/H+ exchanger 1 has tumor suppressive activity and prognostic value in esophageal squamous cell carcinoma (2017, NA)
• ΔNp63A and microRNAs: leveraging the epithelial-mesenchymal transition (2017, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors (2017, Homo sapiens,Mus musculus)
• Therapeutic potential of targeting the PI3K pathway in pediatric brain tumors (2017, Homo sapiens,Mus musculus)
• Network model of oncogenic signal transduction in ER+ breast cancer (2017, NA)
• Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells (2017, NA)
• Model describing the effect of a synergy between extracellular TGFB1 and Hsp90B on downstream signalling in colon cancer cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo (2017, NA)
• Pathway alteration scores in corn1 mice vs (2017, Oryza sativa,Zea mays,Homo sapiens,Mus musculus)
• Signaling pathway networks (2017, NA)
• Proposed model for the autophagy process during E (2017, Ehrlichia chaffeensis)
• Putative mechanism for the interaction between miRNA and the Ago2, Pum2, and REST proteins (2017, NA)
• Schematic illustration representing the microglial intracellular Ca2+signaling mediated by canonical transient receptor potential 3 (TRPC3) channels and the tripartite synapse (2017, NA)
• Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway (2017, NA)
• 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis (2017, NA)
• Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells (2017, NA)
• Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells (2017, NA)
• Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells (2017, NA)
• Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer? (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Warburg effect, hexokinase-II, and radioresistance of laryngeal carcinoma (2017, NA)
• Crosstalk between microRNAs and the Wnt/Beta-catenin signaling pathway in cancer (2017, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Polygonatum odoratum,Homo sapiens,Helicobacter pylori,NA)
• Integrated genomic and molecular characterization of cervical cancer (2017, NA)
• Critical DDR Pathways for UV induced DNA Damage: (1) UV induces an intrastrand lesion, causing the replication fork to stall in S-pase (2017, NA)
• Schematic diagram depicting the role of Hoxa2 in proliferation and osteogenic differentiation of the palatal mesenchyme (2017, Homo sapiens,Mus musculus)
• Anti-tumor activity of metformin: from metabolic and epigenetic perspectives (2017, NA)
• Dysregulation of long non-coding RNA in breast cancer: an overview of mechanism and clinical implication (2017, NA)
• Cancer upregulated gene 2 induces epithelial-mesenchymal transition of human lung cancer cells via TGFB signaling (2017, NA)
• Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells (2017, Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis (2017, Homo sapiens)
• Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis (2017, Homo sapiens)
• Novel non-canonical Wnt signature for prostate cancer aggressiveness (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Canis lupus familiaris)
• Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma (2017, Homo sapiens,Vaccinia virus)
• Magic year for multiple myeloma therapeutics: Key takeaways from the ASH 2015 annual meeting (2017, NA)
• Long noncoding RNAs in head and neck cancer (2017, Homo sapiens,Mus musculus)
• FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cycling hypoxia affects cell invasion and proliferation through regulation of claudins (2017, NA)
• Far-infrared suppresses skin photoaging in ultraviolet B-exposed fibroblasts and hairless mice (2017, NA)
• From big data to diagnosis and prognosis: gene expression signatures in liver hepatocellular carcinoma (2017, NA)
• Series of functions (e.g (2017, Coryphaena hippurus,Homo sapiens)
• Possible interaction between N-methyl-D-aspartate receptors (NMDARs) activation and iron overload (2017, NA)
• Next generation sequencing and its applications in HPVassociated cancers (2017, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Betapolyomavirus macacae,Human papillomavirus types,Merkel cell polyomavirus,Human parvovirus B19,human papillomavirus 18,Betapolyomavirus hominis,JC polyomavirus,Human endogenous retroviruses,Human endogenous retrovirus,Human endogenous retrovirus K,Human endogenous retrovirus H,Torque teno virus,human papillomavirus 35,Human mammary tumor virus,Homo sapiens,Nicotiana tabacum,clinical samples,NA,NA)
• Angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKa/mTOR pathway in vitro and in vivo (2017, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Homo sapiens,Mus musculus)
• Aflatoxin B1 invokes apoptosis via death receptor pathway in hepatocytes (2017, NA)
• Nutrient deprivation in neuroblastoma cells alters 4-hydroxynonenal-induced stress response (2017, NA)
• N-cadherin promotes thyroid tumorigenesis through modulating major signaling pathways (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel (2017, NA)
• miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human betaherpesvirus 5,clinical samples)
• Triple-negative breast cancer: is there a treatment on the horizon? (2017, Oryza sativa,Pleurotus ostreatus,Monascus ruber,Homo sapiens,Mus musculus)
• Sirtuins in glucose and lipid metabolism (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Type I insulin-like growth factor receptor signaling in hematological malignancies (2017, NA)
• PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide (2017, Mus musculus,Rattus norvegicus,Bos taurus,Homotherium serum,Homo sapiens,NA)
• Differentiated regulation of immune-response related genes between LUAD and LUSC subtypes of lung cancers (2017, Homo sapiens,Mus musculus)
• PI3K/Akt/mTOR signaling pathway (2017, Glycine max,Hordeum vulgare,Malus domestica,herbal medicine,Curcuma longa,Brassica oleracea,Allium cepa,Petroselinum crispum,Apium graveolens Dulce Group,Capsicum frutescens,Toxicodendron vernicifluum,Homo sapiens,Mus musculus,Triportheus paranensis)
• Advances in sarcoma diagnostics and treatment (2017, NA)
• Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets (2017, NA)
• Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets (2017, NA)
• Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells (2017, Ophiocordyceps sinensis,Cordyceps militaris,Homo sapiens,Rattus norvegicus)
• Inflammatory signaling pathways in hematopoietic cells and potential therapeutic targets for myeloid malignancies (2017, NA)
• Differentiation potential of mesenchymal stem cells (2017, NA)
• Novel agents and pathways under investigation in MDS (2017, NA)
• Illustration shows the proposed overall mechanism by which butyrate inhibited proliferation and induced apoptosis in hepatic cells (2017, NA)
• Proposed molecular model of VCAM-1 regulation in ccRCC-VHL–expressing cells (2017, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,NA)
• AM966 reduces pulmonary microvascular cell barrier integrity through LPA1/GA12/13-mediated phosphorylation of MLC and VE-cadherin (2017, NA)
• Genes involved in skeletal muscle TLR‐ and insulin receptor signaling related to changes in plasma concentration of fetuin‐A and FFAs (2017, Homo sapiens,Mus musculus)
• Genes involved in adipose tissue TLR‐ and insulin receptor signaling correlated with changes in plasma concentration of fetuin‐A and FFAs (2017, Homo sapiens,Mus musculus)
• Akt/mTOR signaling schematic (2017, Homo sapiens,Mus musculus,Bos taurus,Candida dubliniensis)
• M1 macrophage metabolism (2017, NA)
• Signaling pathway network model: Panel (a) presents the biological network describing the mTOR pathway (based on Fig (2017, NA)
• Glioblastoma stem cells are characterized by self-renewal (2017, NA)
• Targetable molecular features of primary mediastinal large B-cell lymphoma and mediastinal gray zone lymphoma (2017, NA)
• E2 and CTNNB1 signals in the oviductal ciliated and secretory epithelial cells regulating embryo transport (2017, Mus musculus,Homo sapiens)
• Schematic model of AA release in endothelial cells (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Tight junction pathway overrepresented among Qki5 HITS-CLIP target genes based on DAVID-KEGG pathway analysis (2017, Homo sapiens,Mus musculus,Gallus gallus)
• Coincidence detector model for how mTORC1 integrates signals from nutrients and growth factors to regulate growth (2017, NA)
• Signaling pathways involved in the antihypertrophic effects of GHRH in vitro (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• p27-driven dose-responsive pathways in cancer gene networks (2017, NA)
• Thyroid hormone-induced interference with resveratrol-induced antiproliferation is blocked by tetrac and its nanoparticulate analog (2017, NA)
• Proposed metabolic pathway for C4-dicarboxylic acid production by A (2017, NA)
• Microglia-derived IL-1B contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats (2017, NA)
• Mammalian target of rapamycin (mTOR) signaling pathway and possible involvement of rare diseases in the pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Translating genomic profiling to gastrointestinal cancer treatment (2017, NA)
• Translating genomic profiling to gastrointestinal cancer treatment (2017, NA)
• Predicted pathways deregulated during ZIKV infection (2017, NA)
• Suppression of type I IFN production by Flaviviridae viruses (2017, West Nile virus,Japanese encephalitis virus,Kunjin virus,Langat virus,Dengue virus,Zika virus,Yellow fever virus,Dengue virus type 2,Tick-borne encephalitis virus,Tick-borne flavivirus,West Nile virus strain NY-99,Simian foamy virus,Homo sapiens,Mus musculus,Escherichia coli,NA,NA,NA)
• Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway (2017, NA)
• Iron in Type 1 Diabetes Etiology: A Systematic Review of New Evidence on a Long-Standing Mystery (2017, NA)
• Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? (2017, Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mouse mammary tumor virus)
• Screening circular RNA expression patterns following focal cerebral ischemia in mice (2017, Drosophila melanogaster,Homo sapiens)
• Baicalein inhibits progression of osteosarcoma cells through inactivation of the Wnt/Beta-catenin signaling pathway (2017, Armoracia rusticana,herbal medicine,Scutellaria baicalensis,Homo sapiens,Mus musculus,Bos taurus)
• Increased transcriptional and metabolic capacity for lipid metabolism in the peripheral zone of the prostate may underpin its increased susceptibility to cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Association network of linc-RPIA identified in co-module 1 (2017, NA)
• Hippo signaling pathway is the only pathway enriched with up-regulated DEGs (2017, Apis mellifera)
• Diagram showing the various effects as well as the different pathways activated by ouabain in ADPKD cells (2017, NA)
• High-Concentrate Diet Induced Milk Fat Decline via Glucagon-Mediated Activation of AMP-Activated Protein Kinase in Dairy Cows (2017, NA)
• Screenshot of PathwayMapper (2017, NA)
• Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma (2017, Homo sapiens,Mus musculus,Bos taurus,Actinidia deliciosa)
• Regulatory T cell development (Churlaud et al (2017, NA)
• Schematic overview of metabolic pathways of P (2017, NA)
• Effect of SAT1/2, SAT3 and CS3 gene silencing and L-cysteine depletion on sulfur-containing amino acid metabolism (2017, NA)
• Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma (2017, Homo sapiens,Mus musculus,Bos taurus,Actinidia deliciosa)
• Diagrammatic presentation of the mechanism of EMAP-II in combination with TMZ suppressed malignant biological behaviors of GSCs via miR-590-3p/MACC1 inhibiting PI3K/AKT/mTOR signaling pathway (2017, NA)
• Metabolic reprogramming drives: (A) T-cell fate and function and (B) antitumor-immune response (2017, NA)
• JAK-STAT signaling pathway (2017, NA)
• Temozolomide post pazopanib treatment failure in patients with advanced sarcoma: A case series (2017, Homo sapiens)
• Management of intracranial melanomas in the era of precision medicine (2017, NA)
• Signal pathway integration that regulates Hsp90 expression (2017, NA)
• Targeting Notch signalling pathway regulates angiogenesis in the pathological ovary (2017, Homo sapiens,Mus musculus,Rattus norvegicus,marmosets)
• Resistance to targeted therapies (2017, NA)
• Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? (2017, Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mouse mammary tumor virus)
• Scheme summarizing the protective effects of Xn on LPS-induced acute lung injury via activation of the AMPK/GSK3Beta-Nrf2 axis (2017, Mus musculus,Rattus norvegicus,Ginkgo biloba,Humulus lupulus,Homo sapiens,Bos taurus,Escherichia coli)
• Different molecular mechanisms that can induce time-delay necessary for the generation of oscillations in transcription factor activity (2017, NA)
• Mechanism of action of dioscin against pancreatic cancer (2017, Mus musculus,Homo sapiens)
• Occurrence and regulatory mechanisms of ferroptosis in a cell (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Sus scrofa,Microbacterium aurantiacum)
• Schematic form of the proposed pathway mechanisms for phycocyanin-induced apoptosis and autophagy in tumor cells (2017, NA)
• Over-expressed genes of Basal-like samples in p53 signaling pathway (2017, Homo sapiens,Candida dubliniensis)
• IL2RG-centered gene subnetwork (2017, Oryctolagus cuniculus,Equus caballus,Equus asinus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,prion,Simian immunodeficiency virus)
• MAP2K5-centered gene clusters exclusively based on pathway and physical interactions (2017, Oryctolagus cuniculus,Equus caballus,Equus asinus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,prion,Simian immunodeficiency virus)
• CXCL5-centered gene network upregulated in astrocytes in response to Meth exposure (2017, Oryctolagus cuniculus,Equus caballus,Equus asinus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,prion,Simian immunodeficiency virus)
• Connectivity of genes that were upregulated in astrocytes by Meth (2017, Oryctolagus cuniculus,Equus caballus,Equus asinus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,prion,Simian immunodeficiency virus)
• Analysis of candidate genes using MapMan (2017, NA)
• Molecular mechanisms of PI3K-AKT-mTOR signaling cascade related neurodevelopmental diseases (2017, NA)
• Type I interferon (IFN) signaling (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Streptococcus pneumoniae,Chlamydia trachomatis,Chlamydia muridarum,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Human metapneumovirus,Homo sapiens,Mus musculus,Cryptococcus neoformans)
• Pattern recognition receptor signaling that leads to the induction of type I interferons (IFNs) (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Streptococcus pneumoniae,Chlamydia trachomatis,Chlamydia muridarum,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Human metapneumovirus,Homo sapiens,Mus musculus,Cryptococcus neoformans)
• Nonalcoholic steatohepatitis-related hepatocellular carcinoma: is there a role for the androgen receptor pathway? (2017, NA)
• Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA (2017, NA)
• Mucosal-associated invariant T (MAIT) cell activation (2017, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Enterococcus faecalis,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Salmonella enterica subsp. enterica serovar Typhi,Orientia tsutsugamushi,unidentified influenza virus,Dengue virus,Orthomyxoviridae,Human T-cell leukemia virus type I,Saccharomyces cerevisiae,Candida albicans,Candida albicans 23R,Homo sapiens,Mus musculus,Bos taurus,NA)
• Proposed model of miR-130a mediated dysregulation of mTOR pathway in HGSOC (2017, NA)
• Possible mechanisms underlying how YAP regulated LRP1 by promoting proliferation and metastasis of melanoma cells and also reducing apoptosis (2017, NA)
• Molecular functions of long non-coding RNAs (lncRNAs) at different stages of prostate cancer, from prostate adenocarcinoma (A) to ongoing castration resistance (B) to a castration-resistant state (C) (2017, Homo sapiens,Mus musculus)
• Mutation in the von Hippel–Lindau gene (VHL) induces loss (red ×: HIF-2a is no longer inhibited) of the regulatory tumour suppressor p-VHL and catalyses the “von Hippel–Lindau-hypoxia-inducible factor” VHL-HIF pathway (2017, NA)
• Toll-like receptors (TLRs) and TLR-mediated signaling pathway (2017, Human immunodeficiency virus,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Reovirus sp.,Serratia marcescens,Modified Vaccinia Ankara virus,Homo sapiens,Mus musculus,Drosophila melanogaster,synthetic RNA,Larix kaempferi,NA)
• Putative cellular signaling pathways responsible for the lipid emulsion (LE)-mediated inhibition of toxic-dose bupivacaine-induced vasodilation during sodium orthovanadate (Na3VO4)-induced contraction in isolated endothelium-denuded rat aortae (2017, NA)
• Mammalian target of rapamycin (mTOR) pathway (2017, NA)
• p53 promotes apoptosis and inhibits autophagy (2017, NA)
• Wnt/Beta-catenin pathway is potentially deregulated in PCas (2017, NA)
• Proposed interaction of AQP1 with Wnt/ Beta-catenin signalling and cadherin-catenin complex (2017, NA)
• Wnt Pathway: In the presence of Wnt ligands, Dsh blocks the Beta-catenin destruction complex consisting of Axin, APC, CK1, GSK3B (2017, NA)
• Sonic Hedgehog Pathway: Shh acts on Ptch to inhibit the repression of Smo by Ptch (2017, NA)
• Molecular mechanisms associated with inflammatory and oxidative stress in response to chronic exposure to PM0.1 (2017, NA)
• Summary of cross-talk between cancer cells and the tumour microenvironment mediated through the 5-lipoxygenase pathway (2017, NA)
• Signaling pathway of breast cancer download from KEGG website– with targeted genes and pathways from germacrone, curdione, and furanodiene (2017, Curcuma wenyujin,Curcuma phaeocaulis,Homo sapiens,Mus musculus,Molva molva)
• Cellular metabolic pathways driving mononuclear phagocyte inflammatory vs (2017, NA)
• Phylogenetic relationships of algae thiorredoxin-like ferredoxin domains (2017, Saccharomyces cerevisiae,Arabidopsis thaliana,Embryophyta,PX clade,Arachis hypogaea,Spinacia oleracea,Chlamydomonas reinhardtii,Chlorophyta,Phaeodactylum tricornutum,Thalassiosira pseudonana,Stramenopiles,Ostreococcus tauri,Dunaliella salina,Cyanidioschyzon merolae,Emiliania huxleyi,Volvox carteri,Chondrus crispus,Ectocarpus siliculosus,Chlorella variabilis,Porphyridium purpureum,Nannochloropsis oculata,Nannochloropsis gaditana,Nannochloropsis oceanica,Ostreococcus sp. lucimarinus,Micromonas pusilla,Breviolum minutum,Aureococcus anophagefferens,Simmondsia chinensis,Fragilariopsis cylindrus,Cyanophora paradoxa,Coccomyxa subellipsoidea,Micromonas commoda,Guillardia theta,Vernicia fordii,Lobosphaera incisa,Pseudo-nitzschia multiseries,Volvox carteri f. nagariensis,Bathycoccus prasinos,Phaeocystis globosa,Escherichia coli,Escherichia coli BL21,Synechocystis sp.,Aquifex aeolicus,Cupriavidus necator H16,Rhodococcus opacus PD630,Parvimonas sp.,Haliangium ochraceum,Alveolata,Bigelowiella natans,Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus)
• Potential mechanisms involved in T helper type 17 (Th17) differentiation under T‐bet over‐expression conditions (2017, NA)
• Interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor complexes (2017, NA)
• Pathway of VEGFR-2 (produced using the Pathway Builder Tool) (2017, NA)
• Wnt receptor signaling pathway and regulation of Rab GTPase activity involved in miRNA expression (2017, NA)
• The mechanism of pCaM activating PI3KA (2017, NA)
• Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis (2017, NA)
• Fatty acid (FA) and cholesterol sensing in T cell immune responses (2017, NA)
• Adipose tissue pathways regulated by sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) based on current literature in mouse models, adipocyte cell lines and human studies (2017, NA)
• Cellular NAD+ biosynthesis and consumption processes (2017, NA)
• BMP4 cellular signaling pathway including activators and inhibitors (2017, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Vaccinia virus)
• Interactions between TGFB1, canonical WNT/Beta-catenin pathway and PPAR G in radiation-induced fibrosis (2017, NA)
• Regulation of the Hippo-YAP pathway by extracellular biophysical cues (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Melatonin as a potential inhibitory agent in head and neck cancer (2017, Nicotiana tabacum,PX clade,Rubus idaeus,Leucaena leucocephala,Bos taurus,Ovis aries,Sus scrofa domesticus,Gallus gallus,Turdus migratorius,Homo sapiens,Mus musculus)
• Therapeutic potential of cell cycle targeting in multiple myeloma (2017, Homo sapiens,Mus musculus)
• Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? (2017, Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mouse mammary tumor virus)
• Proposed model for metformin’s action (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Papaya ringspot virus)
• Innate immune response to RSV: Advances in our understanding of critical viral and host factors (2017, NA)
• Bile acid homeostasis (2017, NA)
• Proposed salinity tolerance mechanism in Cicer arietinum L (2017, Cicer arietinum,Homo sapiens)
• Highest confidence network of genes significantly dysregulated by miR-7 (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Interrelationships between growth factor, nutrient availability and energy sensing pathways in metabolic regulation in health (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Canis lupus familiaris)
• Signalling pathways implicated in age-related metabolic decline (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Canis lupus familiaris)
• Simplified diagram depicting canonical and non canonical Beta-catenin signalling pathways in bone (2017, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Bos gaurus)
• An overview of signaling nexus of autophagy pathways (2017, NA)
• Example module (L1) more densely connected in ER- group with red nodes indicate genes belonging to the immune response pathway (2017, NA)
• Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets (2017, Bos taurus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Armoracia rusticana)
• Schematic to illustrate model of Wnt pathway (2017, Danio rerio,Armoracia rusticana,Nicotiana tabacum,Diaporthe sclerotioides,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,unidentified)
• Cox1 synthesis and assembly pathway (2017, NA)
• Overview of metabolic changes in RIL165 and RIL387, visualised by MapMan (2017, Cercospora zeina,Homo sapiens)
• Molecular pathways regulated by ZNFs in physiological conditions (2017, Mus musculus,Rattus norvegicus,Xenopus laevis,Cyprinus carpio,Homo sapiens,Human immunodeficiency virus)
• Connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? (2017, Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mouse mammary tumor virus)
• Interconnection between endoplasmic reticulum (ER) stress/unfolded protein response (UPR) pathways and mitochondria-NLRP3 inflammasome in allergic diseases (2017, Saccharomyces cerevisiae,Aspergillus fumigatus,Homo sapiens,Mus musculus)
• Proposed model of IRAK4 regulation of TLR7/8 signaling pathway in human monocytes is shown (2017, Homo sapiens,Mus musculus)
• Working model of the action of PEDF + DHA in enhancing corneal nerve regeneration (2017, NA)
• Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis (2017, NA)
• Role of DHT- and EST-regulated proteins in energy metabolism (2017, Homo sapiens,Mus musculus)
• NO has pre- and postsynaptic effects in ACs (2017, NA)
• Roles of TSP-1 in diverse pathological processes (2017, NA)
• Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment (2017, NA)
• Schematic diagram of the signalling pathway of K5 in the regulation of tumour angiogenesis and tumour cell apoptosis (2017, NA)
• Summary of observations on neuronal damage by two different strains of Zika virus (2017, Zika virus,Homo sapiens,Bos taurus,Oryctolagus cuniculus,Chlorocebus aethiops,Mus musculus,Matthiola incana,NA)
• Brief diagram of the effects of escin on osteosarcoma cells (2017, NA)
• Selected miRNA-mRNA interaction networks involved in Jak-STAT signaling pathway (2017, NA)
• Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling (2017, Mus musculus,Rattus norvegicus,Sus scrofa,Sus scrofa domesticus,Homo sapiens)
• Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis (2017, Homo sapiens,Bathymaster signatus)
• Selected miRNA-mRNA interaction networks involved in T cell receptor signaling pathway (2017, NA)
• Metabolic pathways for engineering oleaginous yeasts to produce a variety of different compounds (2017, NA)
• Direct, indirect, and combined epigenetic pathways of Integrative Medicine (2017, herbal medicine,Allium cepa,Zingiber officinale,Cicer arietinum,Mangifera indica,Lavandula angustifolia,Mucuna pruriens,Vigna mungo,Hydrastis canadensis,Lycopodium clavatum,Mus musculus,Rattus norvegicus,Homo sapiens,Apis mellifera)
• JAK-STAT and chemokine signaling pathwaysA (2017, Homo sapiens,Mus musculus,Myeloproliferative leukemia virus)
• Interplay between CD 36 and AMPK in modulating cellular metabolic pathways with adequate or excess dietary fat, in physiological and pathophysiological conditions (2017, Saccharomyces cerevisiae,Glycine max,Candida dubliniensis,Olea europaea,Arachis hypogaea,Theobroma cacao,Dryobalanops aromatica,Saccharomyces cerevisiae VR1,Cucumis anguria,Mus musculus,Rattus norvegicus,Escherichia coli IS1,Escherichia coli SCD1,Homo sapiens,Bos taurus,Gallus gallus,Respiratory syncytial virus,Drosophila suzukii)
• Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system (2017, NA)
• Proposed mechanism of reciprocal interaction between IP3 and ryanodine receptors in the induction of hyperalgesic priming (2017, NA)
• Merkel cell carcinoma (2017, NA)
• Model illustrating how Hippo pathway regulates JNK-dependent cell invasion (2017, Homo sapiens,Drosophila melanogaster,Gallus gallus)
• Downregulation of MMP1 in MDS-derived mesenchymal stromal cells reduces the capacity to restrict MDS cell proliferation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,clinical samples)
• Schemes of kinetic model used as a base for simulation of isotopologue distribution (2017, Mus musculus,Rattus norvegicus,Mus sp.,Homo sapiens,Bos taurus,Venustaconcha ellipsiformis,Zanthoxylum madagascariense)
• The endothelial cell and monocyte in early stages of atherosclerosis: potential mechanisms of milk derived bioactive peptides (2017, NA)
• L-Tyrosine biosynthesis via two pathways in plants and microbes (2017, Escherichia coli,Escherichia coli K-12,Haemophilus influenzae,Synechocystis sp. PCC 6803,Zymomonas mobilis,Aquifex aeolicus,Bifidobacterium dentium,Streptococcus mutans S1B,Ignicoccus hospitalis,Methanothrix harundinacea,Brucella intermedia,Sediminispirochaeta smaragdinae DSM 11293,Phenylobacterium immobile,Brucella intermedia LMG 3301,Saccharomyces cerevisiae,Arabidopsis thaliana,Glycine max,Solanum lycopersicum,Embryophyta,PX clade,Sorghum bicolor,Vigna radiata,Homo sapiens)
• Syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFB and Activin pathways (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Macaca mulatta,Moloney murine leukemia virus,Notolabrus celidotus)
• Data-Driven Discovery of Extravasation Pathway in Circulating Tumor Cells (2017, NA)
• Schematic diagram depicting proposed mechanism for the Wnt signaling pathway activation during differentiation of ADSCs into insulin-producing cells (2017, NA)
• TGFB signaling pathway (2017, Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,vectors)
• MAPK signaling pathway (2017, Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,vectors)
• EGR1 regulations and functions in the central nervous system in the context of synaptic plasticity (2017, Mus musculus,Rattus norvegicus,Microtus ochrogaster,Homo sapiens)
• FASN-regulated ERA signaling in breast cancer cells: a working model (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana,Xenopus laevis)
• Schematic presentation of the tricarboxylic acid cycle (TCA) pathway and amino acid biosynthesis, as affected by the chlorotic mutation (2017, Arabidopsis thaliana,Oryza sativa,Solanum lycopersicum,Camellia sinensis,Manihot esculenta,Aphis glycines,Autographa gamma,Mus musculus,Homo sapiens)
• Interactions between PPAR gamma and the canonical Wnt/beta-catenin pathway in type 2 diabetes and colon cancer (2017, NA)
• Interactions between the canonical Wnt/beta-catenin pathway and PPAR gamma under aerobic glycolysis conditions in colon cancer (2017, NA)
• Diagram showing the possible mechanism involved in the difference between the angiotensin-converting enzyme (ACE) I/D polymorphisms affecting the generation of kinin peptide agonists for B2R and B1R in the downstream variation signaling effects (2017, Homo sapiens,Mus musculus)
• Kynurenine pathway (KP) (2017, NA)
• Example of a visualisation of a significant pathway using the SetRank package (2017, NA)
• Role of Krüppel-like factor 15 in podocyte differentiation (2017, Homo sapiens)
• Regulatory networks of selected lncRNAs involved in the development of HBx-HCC (2017, NA)
• NRG–ErbB signaling pathway (2017, Homo sapiens,Mus musculus,Bos taurus,Nicotiana tabacum,clinical samples)
• Putative crosstalk among Ca2+, ROS and apoptosis in cassava storage roots during PPD (2017, NA)
• Representation of the LPS biosynthetic pathway (2017, NA)
• Diagram of signaling pathways that control Notch expression in PC (2017, NA)
• Diagram of Notch signaling (2017, NA)
• Modulating the repair-associated inflammatory response in liver fibrosis by the injury-related activation of hedgehog (Hh) signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Helicobacter pylori,Hepatitis B virus,Paraechinus aethiopicus)
• Proteomics and tracing experiments reveal the presence of previously unappreciated metabolic pathways in mature RBC.(A) An overview of the central metabolic pathways that are reasonably active in RBC in the light of proteomics evidence (2017, NA)
• Site-specific gene expression profiling as a novel strategy for unravelling keloid disease pathobiology (2017, NA)
• Differential phosphorylation of YBX1 on Ser-176 and Ser-165 and their role in NFKB activation (2017, NA)
• Proposed mechanistic model for TGFB1/Smad3-mediated control of hepatic gluconeogenesis via targeting of PP2A, LKB1, AMPK, and FoxO1 (2017, Mus musculus,Homo sapiens)
• PAF-mediated endotoxin tolerance (2017, Homo sapiens,Mus musculus)
• Theoretical concept of combined application of checkpoint blockade therapy and DGK-inhibition (2017, NA)
• Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons (2017, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Drosophila melanogaster,Danio rerio,Sequoia sempervirens)
• Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage (2017, NA)
• Proposed model for the role of ADAP2 in antiviral response (2017, NA)
• Proposed mechanisms underpinning the beneficial neurological action of glucagon-like peptide-1 (GLP-1) receptor (R) agonists (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• The compensatory B‐cell proliferative signaling network mediated by insulin resistance (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• The possible role of the polyol pathway in diabetes atherosclerosis (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Diaporthe sclerotioides)
• Schematic representation of the regulatory mechanism about PLOD2 was summarized (2017, NA)
• Trafficking pathways of E-cadherin (2017, Homo sapiens,Drosophila melanogaster)
• Transgenic expression of fungal accessory hemicellulases in Arabidopsis thaliana triggers transcriptional patterns related to biotic stress and defense response (2017, Arabidopsis thaliana)
• Proposed biosynthetic pathway of sex pheromone production in female DBM moths (adapted from [, , ]) (2017, NA)
• MNT and its place in the MAX-MLX network of interacting proteins (2017, NA)
• Fibroblast growth factor-4 (FGF4) signal transduction pathway governs trophoblast proliferation and differentiation (2017, NA)
• Diagrammatic representation of the EGF signaling pathway (2017, Drosophila melanogaster,Venustaconcha ellipsiformis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Xenopus laevis)
• Proposed roles of AR and WNT signaling in mammary gland development and breast cancer (2017, Homo sapiens)
• Canonical WNT signaling pathway (2017, Homo sapiens)
• For PD-L1 modulation in HNSCC (2017, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Listeria monocytogenes)
• IFN pathway of elephant shark (2017, NA)
• Apelinergic signaling pathway (2017, NA)
• Metabolic changes in the midgut of Eri silkworm after Oral administration of 1-deoxynojirimycin: A 1H-NMR-based metabonomic study (2017, Bombyx mori,Penaeus vannamei,Tenebrio molitor,Bactrocera dorsalis,Mamestra brassicae,Samia ricini,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Morus alba)
• Schematic comparison of different oncogenic Ras signaling in RasMUT and RasGRP1-overexpressing T-ALL (2017, Homo sapiens,Mus musculus)
• Roles of LncRNAs in the malignant transformation of breast CSCs (2017, NA)
• LncRNAs network in malignant transformation of HCC stem cells (2017, NA)
• ChREBP regulates fructolytic gene expression (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Zea mays,NA)
• Proposed anti-inflammatory mechanism of chlorogenic acid (CHA) and caffeic acid (CA) in human intestinal epithelial cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Olea europaea,Homo sapiens)
• LSS improves cognitive function and prevents neuronal injury of AD rats via inhibiting the neuronal apoptosis signaling pathway (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Equus caballus,Cricetulus griseus,Litchi chinensis,Scutellaria barbata,Homo sapiens)
• Sensing infection and tissue damage (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,unidentified influenza virus)
• NOD-like receptor signaling pathway (2017, NA)
• RIG-I-like receptor signaling pathway (2017, NA)
• Toll-like receptor signaling pathway (2017, NA)
• Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Saccharomyces cerevisiae,Myxoma virus)
• Mammalian isoprenoid biosynthetic pathway with associated inhibitors (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Triticum aestivum)
• Kynurenic acid (KYNA)-mediated pathways of inflammatory signaling (2017, NA)
• The SOLLI model predicts targets of therapy (2017, NA)
• Heterogeneous responses of normal and malignant B cells upon CpG ODNs stimulation (2017, NA)
• Effects of TAMs on tumor progression (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Pseudomonas aeruginosa)
• WNK kinases in development and disease (2017, Homo sapiens)
• Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway (2017, NA)
• Nitric oxide dose effect on mitochondrial function and endoplasmic reticulum stress (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage (2017, NA)
• Effect of Salmonella infection in inflammatory bowel disease (IBD) patients (2017, Escherichia coli,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Clostridioides difficile,Pseudomonas fluorescens,Clostridioides difficile CD3,Mycobacterium avium subsp. paratuberculosis,Helicobacter pylori SS1,Clostridioides difficile CD18,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Equus caballus)
• Type III IFN signaling pathway (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Orthomyxoviridae,Human betaherpesvirus 5,Vesicular stomatitis virus,Human T-cell leukemia virus type I,West Nile virus,H5N1 subtype,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Encephalomyocarditis virus,Human orthopneumovirus,SARS coronavirus NS-1,Human metapneumovirus,Murine norovirus,SARS coronavirus ExoN1,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Enterococcus faecalis,Shigella flexneri,Borreliella burgdorferi,Chlamydia trachomatis,Staphylococcus epidermidis,Homo sapiens,Macaca mulatta,Cheirogaleus major,Plasmodium falciparum,Thomomydoecus minor,Mus musculus,Tinamus major,NA,NA,NA,NA,NA,NA)
• Gamma-aminobutyric acid signaling pathway (2017, NA)
• Sema3A signaling in bone remodeling (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Nymphalis io)
• Discovery of IDO1 inhibitors: from bench to bedside (2017, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Crosstalk between the Hh and Wnt pathways forms regulatory loops (2017, NA)
• Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Wnt signaling pathway leads to the accumulation of Beta-catenin in nucleus (2017, NA)
• NOD-like receptor signaling pathway from KEGG shown with drugs, targets and known mechanism of action (→ denotes activation, ---> and ---> denote indirect effect and — denotes binding/association) (2017, Homo sapiens)
• Schematic molecular mechanisms of EGCG and curcumin activity (2017, Mus musculus,Rattus norvegicus,Curcuma longa,Camellia sinensis,Homo sapiens,Escherichia coli,Avian erythroblastosis virus)
• BM-MSC modulates inflammation response through mTORC1-p70S6K/mTORC2-Akt Signal Pathway (2017, NA)
• Proposed mechanisms of Notch and Wnt/Beta-catenin signaling in GC progression (2017, Viridiplantae,Dioscorea bulbifera,Homo sapiens,Mus musculus,Bos taurus)
• MiR-30d- MYPT1-cJUN pathway (2017, Homo sapiens,Mus musculus,clinical samples)
• New targets to alleviate skeletal muscle inflammation: role of microRNAs regulated by adiponectin (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli K-12,Homo sapiens)
• Regulation of adiposity by mTORC1 (2017, NA)
• Pathways of HIF-1A and its target genes involved in retinal neuroprotection (2017, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Lycium barbarum,Homo sapiens,Bos taurus,Adeno-associated virus,Coturnix coturnix,Conus striatus)
• Dual functions of IRF3 in antiviral defense (2017, NA)
• Contribution of BBB breakdown and dysregulated BBB transport to AD pathophysiology based on findings in animal models, as shown in and (2017, NA)
• Road to Crohn’s disease (2017, NA)
• Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus (2017, NA)
• Osteoblastic differentiation-related molecular mechanism under combined cytokine treatment (2017, NA)
• Scheme summarizing the protective effect of isoliquiritigenin (ISL) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the underlying mechanisms (2017, Armoracia rusticana,Ginkgo biloba,Glycyrrhiza uralensis,Citrus aurantium,Aralia continentalis,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli)
• Neural tube closure: cellular, molecular and biomechanical mechanisms (2017, Gallus gallus,Danio rerio,Xenopus laevis,teleost fish,Oryzias latipes,Phoenicopterus roseus,Ambystoma mexicanum,Gehyra xenopus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Drosophila melanogaster,Ciona intestinalis,Homo sapiens)
• Plant pathogen interaction pathway, Kyoto Encyclopedia of Genes and Genomes (KEGG): fve04626, in Fragaria vesca (http://www.ncbi.nlm.nih.gov/guide/genomes-maps/) (2017, NA)
• Proposed molecular talking points between TLRs, Wnt, and nuclear factorKB (NFKB) (2017, NA)
• General overview of the Wnt signaling pathway (2017, NA)
• TLR molecular cascade (2017, NA)
• Apoptosis signaling pathway (2017, NA)
• 10-miRNA-score predicts defects in the HR pathway in ovarian cancer (2017, NA)
• Network of miR-93 and miR-21 with putative target genes of important signaling pathways from KEGG enrichment analysis (2017, NA)
• Summary and pathway schematic (2017, NA)
• MapMan overview of significant (FDR adjusted p ≤ 0.05 & log2 fold change ≥2) differentially expressed loci (SDEL) involved in biotic stress pathway, unique to PB1+Pi9, upon M (2017, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Embryophyta,Triticum aestivum,Hordeum vulgare,Daucus carota,Pyricularia oryzae,Oryza sativa Japonica Group,Pyricularia grisea,Oryza sativa Indica Group,Rhizoctonia solani,Pseudomonas syringae,Xanthomonas oryzae pv. oryzae,Xanthomonas oryzae,Pseudomonas coronafaciens pv. oryzae,Homo sapiens)
• Schematic model summarizing the findings of the proteomic and metabonomic profiling analyses (2017, NA)
• Representative signalling pathway of human TLRs in the cell membrane (TLR1/2, TLR2/6, TLR4, TLR5, and TLR10) and endosome (TLR3, TLR4, TLR7, and TLR9) (2017, NA)
• Oxidative Stress Alters the Profile of Transcription Factors Related to Early Development on In Vitro Produced Embryos (2017, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Mus musculus,Cricetus cricetus,Homo sapiens,Calloplesiops altivelis)
• Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Sirtuin roles in Hedgehog, Wnt/B‐catenin, and Notch stem cell signaling pathways (2017, NA)
• Summary of studies and new suggested working model of the Q pathway to pMF (2017, NA)
• CORM-2 influences IBA-1- and GFAP-positive cells and many nociceptive factors and signaling pathways as measured on day 7 after CCI (2017, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• The Wnt signaling pathway and the role of Mule during its constitutive activation (2017, Mus musculus,Equus asinus x Equus caballus,Homo sapiens)
• Ingenuity Pathway Analysis (IPA) comparisons of the quantified readouts from (2017, NA)
• Similar signaling cascades involved with neuroprotection for insulin-like peptides and sex hormones (2017, NA)
• Schematic model of TREM2 in the regulation of Beta-catenin signaling and microglial survival (2017, NA)
• Role of EGF Receptor Signaling on Morphogenesis of Eyelid and Meibomian Glands (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Layers of gene expression control in primed human PSCs (2017, Homo sapiens,Mus musculus)
• Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling (2017, NA)
• Epsin-dependent ligand endocytosis activates Notch by force (2017, Bos taurus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Raphanus sativus,S2-like reptarenavirus)
• Tgfbr2 cKO CD34+ SCC cells upregulate genes implicated in invasive human cancers (2017, Mus musculus,Homo sapiens)
• Insulin action and resistance in obesity and type 2 diabetes (2017, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Equus caballus,Homo sapiens)
• Kynurenine pathway metabolism and neuroinflammatory disease (2017, NA)
• Identification of miRNA-mRNA Modules in Colorectal Cancer Using Rough Hypercuboid Based Supervised Clustering (2017, NA)
• Diagram of immune responses induced by Leptospira sp (2017, Leptospira interrogans,Leptospira sp.,Homo sapiens)
• Schematic drawing illustrating the effects of the Kir4.1 inhibition on the BDNF expression in astrocytes (2017, NA)
• Findings of network and pathway analysis (2017, NA)
• Glucocorticoid-driven network links many of the top-ranked PLSR genes (2017, NA)
• Pervasive translational regulation of the cell signalling circuitry underlies mammalian development (2017, Saccharomyces cerevisiae,Armoracia rusticana,Solanum lycopersicum,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Danio rerio,NA)
• Pervasive translational regulation of the cell signalling circuitry underlies mammalian development (2017, Saccharomyces cerevisiae,Armoracia rusticana,Solanum lycopersicum,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Danio rerio,NA)
• Our strategy to increase seed oil accumulation by overexpressing the plastidial pyruvate transporter BASS2 under the control of a seed-specific promoter in developing A (2017, Arabidopsis thaliana,Nicotiana tabacum,Glycine max,Triticum aestivum,Brassica napus,Helianthus annuus,Spinacia oleracea,Brassica oleracea,Linum usitatissimum,Phoenix dactylifera,Elaeis guineensis,Brassica napus var. napus,Homo sapiens,Agrobacterium tumefaciens)
• Long non-coding RNA CRNDE acts as a ceRNA and promotes glioma malignancy by preventing miR-136-5p-mediated downregulation of Bcl-2 and Wnt2 (2017, Bos taurus,Equus kiang,Homo sapiens,clinical samples)
• Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds (2017, Bos taurus,Sus scrofa,Ovis aries,Sus scrofa domesticus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Candida dubliniensis,Human immunodeficiency virus,Pieris brassicae)
• Pathways of c-Met signaling (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense (2017, NA)
• Saprolegnia parasitica carbon metabolism (2017, Saprolegnia parasitica,Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Solanum tuberosum,Matthiola incana,Phytophthora infestans,Phytophthora sojae,Phytophthora capsici,Blastomyces dermatitidis,Phytophthora ramorum,Aphanomyces astaci,Phytophthora pisi,Saprolegnia australis,Caenorhabditis elegans,Oncorhynchus mykiss,Calloplesiops altivelis,Salmo trutta,Siproeta stelenes,Astacus leptodactylus,Escherichia coli,Escherichia coli DH1,Homo sapiens,NA)
• De novo assembly of the sea trout (Salmo trutta m. trutta) skin transcriptome to identify putative genes involved in the immune response and epidermal mucus secretion (2017, NA)
• ROS and major signaling pathways (2017, Escherichia coli,Enterococcus faecalis,Porphyromonas gingivalis,Streptococcus mutans,Rattus norvegicus,Mesocricetus auratus,Homo sapiens,Bos taurus,Dipturus trachyderma)
• Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma (2017, NA)
• Recent progress in the research of cold-inducible RNA-binding protein (2017, Mus musculus,Rattus norvegicus,Cricetulus griseus,Xenopus laevis,Lithobates catesbeianus,Homo sapiens)
• Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGFB1 (2017, NA)
• The breast tumor vs mammary gland serial-omics experiment (2017, NA)
• The proposed cellular functions of cellular NLRC5 (2017, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human rhinovirus sp.,Sprivivirus cyprinus,Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Listeria monocytogenes)
• Figure illustrating five pathways putatively causing pathological remodelling in ACM: 1) Deficits in EB-1 ID protein trafficking provoke disturbance of the ID morphology (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• iCOS pathway associated with HIV-1 TAR target genesiCOS signaling in T helper cells (2017, NA)
• Anerobic metabolic routes in C (2017, NA)
• Schematic summary of baicalin-driven regulation of autophagy and inflammation during Mtb infection (2017, Mycobacterium tuberculosis,Homo sapiens)
• Schematic diagram depicting the role of miR-27a in Mycobacterium avium subspecies paratuberculosis (MAP)-mediated signaling pathways in macrophage (2017, Mycobacterium avium,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Haemophilus influenzae,Mycobacterium marinum,Mycobacterium avium subsp. paratuberculosis,Mycobacterium tuberculosis variant bovis BCG str. China,Mycobacterium avium complex sp.,Mycobacterium avium subsp. avium,Mycobacterium marinum str. Europe,Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Japanese encephalitis virus,Murid betaherpesvirus 1,Homo sapiens,NA)
• Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics (2017, NA)
• Changes in upper glycolysis, glycerolipid metabolism and pentose phosphate pathway during aging (2017, NA)
• Bile acids as global regulators of hepatic nutrient metabolism (2017, NA)
• Bile acids as global regulators of hepatic nutrient metabolism (2017, NA)
• Regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease (2017, NA)
• Cytotoxicological pathways induced after nanoparticle exposure: studies of oxidative stress at the ‘nano–bio’ interface †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7tx00119c (2017, Homo sapiens)
• Schematic diagram for the functional mechanism of Aster glehni extract (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Glycine max,Pandanus tectorius,Homo sapiens,Gallus gallus)
• Interferon regulatory factor 5 regulates B cell proliferation and cell cycle (2017, Staphylococcus aureus,Staphylococcus aureus Chi-4,Homo sapiens,Mus musculus,Bos taurus,Lareunionomyces loeiensis,Influenza B virus BShanghai3612002,NA)
• In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment (2017, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli BL21DE3,Limosilactobacillus reuteri,Clostridium butyricum,Clostridium beijerinckii,Alphaproteobacteria,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Lachnoclostridium phytofermentans,Roseburia inulinivorans,Streptococcus mutans S1B,Paraburkholderia xenovorans,Rhodopseudomonas palustris BisB18,Homo sapiens,Rattus norvegicus)
• Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction (2017, NA)
• Outside-in signaling through class I PI3Ks (2017, NA)
• Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken (2017, Bos taurus,Capra hircus,Sus scrofa,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,Gallus gallus)
• Transcriptomic meta-analysis reveals up-regulation of gene expression functional in osteoclast differentiation in human septic shock (2017, NA)
• PD genes and autophagy-endolysosomal pathway(s) (2017, NA)
• Estrogen metabolism pathway including enzymes (blue field) and chemical compounds (2017, Mus musculus,Mesocricetus auratus,Homo sapiens,Nicotiana tabacum,Pleurobema stabile)
• Sketch diagram of the molecular mechanism of LMO2 on regulating lamellipodia/filopodia formation in basal-type breast cancer cells (2017, NA)
• Differentially expressed genes induced in the chronic obstructive pulmonary disease canonical pathway (2017, Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,human papillomavirus 18,human papillomavirus 11,Homo sapiens,Bos taurus,Armoracia rusticana,Escherichia coli DH5alpha)
• Pathways summary showing identified kinases in BTV infected cells (2017, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,West Nile virus,Reovirus sp.,Ebola virus sp.,Bluetongue virus,Rotavirus A,African horse sickness virus,Bluetongue virus 1,African horse sickness virus 1,Bos taurus,Oryctolagus cuniculus,Capra hircus,Lareunionomyces loeiensis,Ovis aries,Equus caballus,Matthiola incana,Cystobasidium portillonense,Pseudopyricularia hyrcaniana,Phaeoacremonium amygdalinum,Rattus norvegicus,Cavia porcellus,Homo sapiens,NA,NA,NA,NA)
• Interaction of lactobacilli with transformed cells (2017, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Lactiplantibacillus plantarum,Mycobacterium tuberculosis variant bovis,Lacticaseibacillus casei,Lactobacillus acidophilus,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Lactobacillus delbrueckii subsp. bulgaricus,Deinococcus radiodurans,Lactobacillus gasseri,Lactobacillus helveticus,Lactobacillus johnsonii,Lactobacillus jensenii,Lacticaseibacillus paracasei subsp. paracasei,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Hierarchical QS network in P (2017, Pseudomonas aeruginosa,Homo sapiens)
• Serum lipid alterations identified in chronic hepatitis B, hepatitis B virus-associated cirrhosis and carcinoma patients (2017, Hepatitis B virus,Human immunodeficiency virus,Hepatitis delta virus,Bluegill hepatitis B virus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Nucleotide excision repair (NER) pathway (2017, NA)
• New perspectives on the development of muscle contractures following central motor lesions (2017, Homo sapiens)
• Phosphoproteomic analysis of SK-ChA-1 cells after ZPCL-PDT (2017, Homo sapiens,Mus musculus,Bos taurus,NA)
• Downstream effects analysis enables prediction of the effect of gene expression changes in each treatment (2017, NA)
• miRNA-mRNA network (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Panax ginseng,Murid betaherpesvirus 1)
• Recognition of human immunodeficiency virus 1 (HIV-1) by innate immune system (2017, NA)
• Exosomal microRNAs (miRNAs), proteins, and muscle mass wasting (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mitochondrial disorders in septic cardiomyopathy (2017, NA)
• Anticancer drugs that induce oxidative stress on endothelial cells (2017, NA)
• Summary of the pathogenesis of inflammation and scarring in ocular MMP (2017, NA)
• Biosynthesis pathway of PGE2 (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Respiratory syncytial virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Coxsackievirus B3,Enterovirus A71,ssRNA viruses,dsRNA viruses,Murine adenovirus 1,Porcine sapovirus,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Cricetulus griseus,Felis catus,Homo sapiens,Chlorocebus aethiops,NA,NA)
• Model indicating the two-step increase in ex vivo lymphocyte Fas surface expression (2017, Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Human T-cell lymphotropic virus,Human T-lymphotropic virus 2,Homo sapiens,Mus musculus,Bos taurus)
• Complement activation and evasion by NS1 protein of flavivirus (2017, NA)
• Activation of the canonical NFKB pathway (2017, Human immunodeficiency virus 1,Human immunodeficiency virus,Human T-cell leukemia virus type I,Simian immunodeficiency virus,Human immunodeficiency virus 2,HIV-1 group M,HIV-1 group O,Homo sapiens,Pan troglodytes,Gorilla gorilla,Cercopithecus mona,Cercocebus torquatus)
• Proposed working pathway for ginsenoside Rg5 action in hypoxic adipose tissue (2017, NA)
• Possible cell-cycle checkpoint pathways in centrosomal (centriolar) integrity or morphology (2017, NA)
• Canonical and alternative pathways for NFKB activation (2017, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Neisseria meningitidis,Francisella tularensis,Mus musculus,Rattus norvegicus,Cavia porcellus,Candida albicans,Aspergillus niger,Prunus domestica,Homo sapiens,Human alphaherpesvirus 1,Meleagris gallopavo)
• Cell death induced by benzopyran compounds by minor chemical modifications of the benzopyran scaffold (2017, NA)
• Schematic representations of potential mechanisms of PEBP1 in enhancing inflammatory response and neuron apoptosis after I/R injury (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,vectors)
• Biphasic concentration-dependent regulation of Cav-1 gene expression and GSK-3B activity by fluoxetine in astrocytes (2017, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana,prion)
• Schematic view of FLT3 and FLT3-ITD signaling.Notes: FLT3 and FLT3-ITD receptors are expressed at the cell Mb (2017, Homo sapiens,Mus musculus,NA)
• Development of a Reporter System for In Vivo Monitoring of Gamma-Secretase Activity in Drosophila (2017, Homo sapiens,Drosophila melanogaster,prion,Simian virus 42)
• myomiRs and muscle mass wasting and atrophy pathways (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Natural anti-CCR5 antibodies (Abs) to ECL1 triggers a Class B CCR5 trafficking pathway in T cells (2017, Human immunodeficiency virus 1,Human immunodeficiency virus,Simian immunodeficiency virus,Human immunodeficiency virus 2,Flock House virus,Homo sapiens,Mus musculus,Macaca mulatta,Cricetulus griseus,Escherichia coli,Simian-Human immunodeficiency virus,NA)
• Regulation of thyroid cancer stem cell (CSC) self-renewal by the sonic hedgehog (Shh) pathway (2017, NA)
• Non-canonical activation of the sonic hedgehog (Shh) pathway (2017, NA)
• Efferocytosis in Atherosclerosis (2017, Homo sapiens,Mus musculus,Candida dubliniensis)
• Sonic hedgehog (Shh) signaling pathway in a mammalian system (2017, NA)
• Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 (2017, NA)
• Wnt/Beta-Catenin Signaling (2017, NA)
• Role of the inflammasome in chronic obstructive pulmonary disease (COPD) (2017, NA)
• AMPAR trafficking during Alzheimer’s disease (AD): early and later phases (2017, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Uranoscopus scaber)
• CSF3R mutations activate kinase signaling to promote the expansion of neutrophils (2017, NA)
• Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases (2017, NA)
• (B–catenin mediated) Wnt signaling pathway (2017, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles (2017, NA)
• Toll-like receptor 4 (TLR4)-NFKB signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Theobroma cacao,NA)
• TGFBeta-Smad signaling pathway in HSC (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Theobroma cacao,NA)
• Potential mechanisms of nicotine plus HFD-induced hepatic steatosis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,gut metagenome)
• Three-Part Signaling System Drives the Inflammatory Response in the Fly(1) In Drosophila, macrophages are initially primed to respond to a wound by engulfing an apoptotic corpse (2017, Escherichia coli,Staphylococcus aureus,Pectobacterium carotovorum,Mycolicibacterium fortuitum,Drosophila melanogaster,Caenorhabditis elegans,Leptopilina boulardi,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Danio rerio,Candida dubliniensis)
• Macrophage Functions in Tissue Patterning and Disease: New Insights from the Fly (2017, Escherichia coli,Staphylococcus aureus,Pectobacterium carotovorum,Mycolicibacterium fortuitum,Drosophila melanogaster,Caenorhabditis elegans,Leptopilina boulardi,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Danio rerio,Candida dubliniensis)
• Metabolic and epigenetic changes associated with pancreatic cancer (2017, NA)
• Nuclear B‐catenin is the hallmark of canonical Wnt signaling (2017, Xenopus tropicalis,Homo sapiens)
• Responses of the marine diatom Thalassiosira pseudonana to changes in CO2 concentration: a proteomic approach (2017, NA)
• Mediterranean versus Red sea corals facing climate change, a transcriptome analysis (2017, Pocillopora damicornis,Stylophora pistillata,Seriatopora hystrix,Balanophyllia europaea,Homo sapiens,Cavia porcellus,PX clade)
• Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea (2017, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Xenopus laevis,Cavia porcellus,Homo sapiens,Drosophila melanogaster)
• Algorithm for the investigation of patients with elevated cardiac troponin concentrations in the context of an alternative acute illness (2017, NA)
• Vitamin D synthesis pathway (2017, NA)
• Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells (2017, NA)
• Functional analysis of the network containing validated segregating variants (2017, Homo sapiens,Drosophila melanogaster,Gallus gallus,Sequoia sempervirens)
• Pathways involved in the vasodilator effect of affinin (2017, NA)
• Phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR), retrovirus-associated DNA sequences/mitogen activated protein kinase (RAS/MAPK) pathways and c-MYC are master regulators of cell growth and proliferation (2017, NA)
• The mTOR signaling pathway (2017, NA)
• Regulation of metabolism and metabolically-regulated signals by integrins (2017, NA)
• MTOR signaling pathway as a target of molecular therapies (2017, NA)
• Unfolded protein response (UPR) pathways in mammalian cells (2017, NA)
• Molecular Biomarkers for Prediction of Targeted Therapy Response in Metastatic Breast Cancer: Trick or Treat? (2017, NA)
• Protein association networks (2017, NA)
• Schematic showing the synergistic relationship between PARP inhibitors and BRCA1/2 (2017, NA)
• Representative apoptosis pathway and associated factors (2017, NA)
• Pathway of ecto-F1-ATPase-mediated holo-HDL endocytosis (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• The G-protein, cAMP/PKA signaling alterations found in the ZMEL-R1 cells (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Diaporthe sclerotioides)
• Working model for cocaine-recruited signaling axis that broadens t-LTP timing window in the PFC (2017, NA)
• Most significantly relevant pathways and highly linked molecules relevant to the merged bionetwork (2017, Homo sapiens,Mus musculus)
• Schematic representation of the role of pancreastatin (PST) in the regulation of insulin secretion from pancreatic beta cells (2017, NA)
• Regulatory T cells are controlled by epigenetic mechanisms and T cell receptor (TCR) and interleukin-2 (IL-2) pathway (2017, Homo sapiens,Mus musculus,Candida dubliniensis)
• Proposed model of CXCL12 signaling to mTORC1 in BMM (2017, Mus musculus,Homo sapiens)
• Fas apoptotic pathway (2017, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells (2017, Homo sapiens,Mus musculus,Bos taurus)
• HPVs infect host epithelial cells through TLRs (2017, NA)
• Regulation of ecdysteroidogenesis (2017, Drosophila melanogaster,Homo sapiens)
• Toll-like receptor signaling (2017, NA)
• B3AR signaling activation in cardiomyocytes (2017, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Canis lupus familiaris,Sus scrofa,Macaca mulatta)
• MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics (2017, NA)
• AGEs-Cyr61-VEGF pathway observed in this study (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Ricinus communis)
• Proposed model of selected miRNA action on the regulatory T cell pathway (2017, Homo sapiens,Mus musculus,Bos taurus,Dermatophagoides farinae)
• Canonical and non-canonical TGFB signaling pathways (2017, NA)
• TGFB/Smad4 signaling pathway (2017, NA)
• Sexual dimorphism in the axonal signaling pathway (2017, NA)
• Functional network of the interferon signaling pathway by IPA (2017, NA)
• Schematic illustrating the pheromone-dependent MAPK pathway in budding yeast (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Xenopus laevis)
• Paradigms of cancer–immune cell interactions (2017, NA)
• Proposed model for the CD271 regulation and potential downstream effects mediating drug resistance and metastasis (2017, NA)
• Mechanistic model of carbohydrate metabolism manipulation by A (2017, Anaplasma phagocytophilum,Ixodes scapularis,Homo sapiens)
• Carbohydrate metabolism in I (2017, Anaplasma phagocytophilum,Ixodes scapularis,Homo sapiens)
• Schematic – activation of SIRT1/AMPK pathway by metoprolol is required to inhibit AF induced by chronic OSA (2017, NA)
• Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective (2017, NA)
• Immune response in the polar clinical forms of leprosy (2017, Mycobacterium tuberculosis,Mycobacterium avium,Mycobacterium leprae,Candida dubliniensis,Candida albicans,Homo sapiens,Mus musculus,Human immunodeficiency virus)
• Human myeloid cells identified in the bone marrow, blood, and tissue of cancer patients (2017, Homo sapiens,Mus musculus)
• Jasmonic acid signaling and activation of defense genes (phenylpropanoids biosynthesis) in response to MeJA elicitation (2017, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Hordeum vulgare,Vitis vinifera,Curcuma longa,Camellia sinensis,Salvia miltiorrhiza,Theobroma cacao,Zingiber officinale,Raphanus sativus,Catharanthus roseus,Solanum melongena,Mangifera indica,Beta vulgaris,Ocimum basilicum,Lolium perenne,Jatropha curcas,Nelumbo nucifera,Pinus sylvestris,Pinus pinaster,Vaccinium corymbosum,Medicago falcata,Persicaria minor,Boesenbergia rotunda,Hylobius abietis)
• Extrinsic and intrinsic pathways of apoptosis (2017, NA)
• TGFB signaling pathways (2017, NA)
• Functional interaction network analysis by GeneMANIA of candidate mouse and human genes related to brain metastasis (2017, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides)
• JAK-STAT signalling pathway (2017, NA)
• Ingenuity pathway analysis of uniquely hypomethylated promoters (2017, NA)
• Recursive random forest algorithm for constructing multilayered hierarchical gene regulatory networks that govern biological pathways (2017, NA)
• Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets (2017, NA)
• Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets (2017, NA)
• Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targets (2017, NA)
• Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway (2017, NA)
• Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox (2017, NA)
• Proposed mechanism whereby RET/PTC3 regulates IDO1 expression in thyroid cancer cells (2017, NA)
• Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine (2017, NA)
• Sex-specific gene expression and life span regulation (2017, NA)
• Nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) pro‐inflammatory signalling pathway (2017, NA)
• Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases (2017, NA)
• Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases (2017, NA)
• Macrophages activated by the classical pathway act as inflammation inducers and are called M1 (2017, Homo sapiens,Mus musculus,Ovis aries,Paullinia cupana)
• MYC-driven self-reinforcing loop in ESCs (2017, Mus musculus,Rattus norvegicus,Avian myelocytomatosis virus,Avian myelocytomatosis virus 29,Homo sapiens)
• MYC regulatory networks in pluripotent stem cells (2017, Mus musculus,Rattus norvegicus,Avian myelocytomatosis virus,Avian myelocytomatosis virus 29,Homo sapiens)
• Major phagocyte modulation pathway induced by gliotoxin from fungal: spore internalization by phagocytes is an essential mechanism to prevent hyphae formation by pathogenic fungi (2017, NA)
• The crosstalk between the Wnt and FGF signaling pathways in fibroblasts (2017, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Bos taurus,Caenorhabditis elegans,Human T-cell leukemia virus type I)
• Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases (2017, NA)
• Pulmonary vascular smooth muscle cell activation (2017, NA)
• Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility (2017, NA)
• Oligodendrocyte Nf1 Controls Aberrant Notch Activation and Regulates Myelin Structure and Behavior (2017, NA)
• Toll-like receptor-mediated actions (2017, Tripterygium wilfordii,Xanthium strumarium,Zanthoxylum myriacanthum,Homo sapiens)
• Activity on macrophages and other mononuclear cells (2017, Angelica sinensis,Xanthium strumarium,Salvia plebeia,Zataria multiflora,Vitex trifolia,Homo sapiens)
• Group I Paks as components of the Ncad/Cdo signaling pathway (2017, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Schematic diagram illustrates the apoptotic pathway being examined and where each drug acts (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Callithrix jacchus)
• The impact of EGFR-ERK pathway on the type I interferon response in human keratinocytes (2017, NA)
• A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review (2017, NA)
• Heat-responsive proteins involved in signal transduction pathway (2017, NA)
• Glucose-inositol relationships (2017, NA)
• Thrombin cleaves the amino-terminal domain of PAR1 and triggers intracellular signaling (2017, NA)
• Schematic model of possible signalling events involved in the upregulation of TGFB1 expression by LTBP-2 (2017, NA)
• Transforming growth factor B (TGFB) and bone morphogenetic protein (BMP) signaling in bone homeostasis (2017, NA)
• Summary of the bone morphogenetic protein (BMP) and growth and differentiation factor (GDF) signaling pathway and mutations causing connective tissue and skeletal disorders (2017, NA)
• Transforming growth factor B (TGFB)-induced activation of the PI3K-Akt pathway (2017, NA)
• Transforming growth factor B (TGFB)-induced activation of c-Jun amino terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling, and the IKB kinase (IKK) pathway (2017, NA)
• Transforming growth factor B (TGFB)-induced activation of the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinase (MAPK) pathway (2017, NA)
• Cellular senescence (2017, NA)
• SCFFBW7 ubiquitin ligase targets SOX9 for proteasomal destruction (2017, NA)
• Interferon signaling pathway as differentially regulated by ZIKV and HCMV in maternal-decidual and fetus-derived chorionic villus tissues (2017, NA)
• Summary of DNA damage-induced breast cancer by estrogen and stressors (2017, NA)
• Regulation of key cancer stem cell signaling pathways by epigenetic mechanisms (2017, NA)
• Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway (2017, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• FGFR signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio,Diaporthe sclerotioides)
• Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype (2017, NA)
• Summary of the transforming growth factor B (TGFB) signaling pathway and mutations causing connective tissue disorders (2017, NA)
• Lipids at membrane contact sites: cell signaling and ion transport (2017, NA)
• Beijing Mycobacterium tuberculosis (M (2017, NA)
• Mutual regulation between miRNAs and the Wnt pathway determine the survival of Mycobacterium tuberculosis (M (2017, NA)
• Nucleotide-binding oligomerization domain 2 (NOD2) and the activation of the Wnt pathway in response to Mycobacterium tuberculosis infection (2017, NA)
• Wnt3 promotes apoptosis in response to Mycobacterium tuberculosis (M (2017, NA)
• Mycobacterium tuberculosis (M (2017, NA)
• Non-canonical Wnt signaling pathway (2017, NA)
• Canonical Wnt signaling pathway (2017, NA)
• A simplified model showing basic differences in the myogenic molecular mechanisms responsible for the initiation of contraction followed by its fade in the phasic (denoted by white tracing line) vs (2017, NA)
• Enhancement of the eNOS-mediated vascular signaling by H2S (2017, NA)
• Schematic presentation that demonstrates a link between purinergic receptor-mediated signaling and cellular metabolic pathways (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic diagram showing the EBV-related pathogenic factors that contributes to cancer pathogenesis via exosomal pathway (2017, NA)
• Ubiquitylation events during TC-NER (2017, NA)
• Ubiquitin signaling during lesion recognition in the GG-NER pathway (2017, NA)
• Redifferentiating Thyroid Cancer: Selumetinib-enhanced Radioiodine Uptake in Thyroid Cancer (2017, NA)
• A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2 (2017, Homo sapiens,Mus musculus)
• A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2 (2017, Homo sapiens,Mus musculus)
• IGF-IR signaling in CSCs-like cells biology (2017, NA)
• Critical factors involved in IGF-IR-mediated EMT process (2017, NA)
• IGF signaling regulation in EMT (2017, NA)
• Signaling involved in CSCs that mediates melanoma progression (2017, NA)
• Biosynthetic pathways of tetrapyrrole compounds (2017, Escherichia coli,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Corynebacterium glutamicum,Cereibacter sphaeroides,Sinorhizobium meliloti,Cupriavidus necator,Rhodobacter capsulatus,Priestia megaterium,Methanocaldococcus jannaschii,Rhodopseudomonas palustris,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Brucella melitensis,Propionibacterium freudenreichii,Propionibacterium freudenreichii subsp. shermanii,Pseudomonas denitrificans nom. rej.,Halobacterium salinarum NRC-1,Eubacterium limosum,Brucella melitensis bv. 1 str. 16M,Thermotoga neapolitana,Rhodobacter capsulatus SB 1003,Thermotoga maritima MSB8,Thermotoga sp. RQ2,Paracoccus pantotrophus,Thermotoga petrophila,Pseudothermotoga thermarum,Pseudothermotoga lettingae,Mesotoga prima,Thermosipho africanus,Fervidobacterium nodosum,Kosmotoga olearia,Petrotoga mobilis,Methanobacterium ivanovii,Thermosipho melanesiensis,Saccharomyces cerevisiae,Zea mays,Homo sapiens,vectors,NA)
• Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans (2017, NA)
• Insulin signalling pathway (2017, NA)
• Summary diagram of JAK/STAT and MAPK signal transduction (2017, NA)
• Induction of interferons (IFNs) and establishment of an antiviral state in a model chicken cell (2017, Influenza A virus,unidentified influenza virus,H1N1 subtype,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,H5N1 subtype,Reovirus sp.,Infectious bronchitis virus,H9N2 subtype,Infectious bursal disease virus,Gallid alphaherpesvirus 2,Duck hepatitis B virus,Avian sarcoma virus,H5N2 subtype,H7N1 subtype,H5N9 subtype,Gallus gallus,Xenopus laevis,Meleagris gallopavo,Anas platyrhynchos,Tetrapoda,Anser sp.,Grus japonensis,Bos taurus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,NA,NA,NA,NA)
• APP-Go signaling can regulate alternative downstream pathways in a context-dependent manner (2017, Drosophila melanogaster,Caenorhabditis elegans,Manduca sexta,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Metabolic control of macrophage activation (2017, NA)
• Molecular mechanisms of JNK1 and JNK2 in obesity-driven insulin resistance (2017, NA)
• Transcriptome Analysis Reveals Comprehensive Insights into the Early Immune Response of Large Yellow Croaker (Larimichthys crocea) Induced by Trivalent Bacterial Vaccine (2017, Larimichthys crocea,Homo sapiens)
• Inhibition of NFKB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy (2017, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana)
• Transcriptome Sequencing of Gracilariopsis lemaneiformis to Analyze the Genes Related to Optically Active Phycoerythrin Synthesis (2017, NA)
• Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives (2017, NA)
• Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism (2017, NA)
• Proposed mechanism underlying HSYA-SDT-induced autophagy and inflammation inhibition in THP-1 macrophages (2017, NA)
• Human EGF signaling pathway (reprinted from Biocarta ) (2017, NA)
• Relationships Between Cellular Proteostasis and Ciliogenesis (2017, NA)
• Regulatory Roles of the Cytoskeleton at the Base of the Cilia (2017, NA)
• Regulation of Ciliogenesis by Inputs from the Cell Cycle (2017, NA)
• Schematic diagram showing the signalling pathway activated by AGE treatment in cardiomyocytes (2017, NA)
• Ricin-induced activation of cell signaling pathways and downstream formation of damage mediators (2017, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Scutellaria baicalensis,Ricinus communis,Homo sapiens,unidentified influenza virus,Plasmodium falciparum,clinical samples)
• miRNAs enriched with OSCC target mRNAs of the neurotrophin signaling pathway (2017, NA)
• CyaA toxin of B.pertussis inhibits the TRIF-dependent signaling pathways in human monocyte derived dendritic cells (MDDC) (2017, NA)
• Hijacking of cellular signaling cascades blocks the bactericidal activities of phagocytes (2017, NA)
• Neutrophil crosstalk with immune and humoral cells and relevant chemical signals that influence and compose the inflammatory response and pathway to resolution via the neutrophil (2017, NA)
• Cross talk between lipid/glucidic metabolism and cancer (2017, NA)
• Regulation of expression and role of ANGPTL4 in lipid metabolism (2017, NA)
• Interaction between PPARs and PPRE (2017, NA)
• Proposed model of the role of the PMCA1 protein in regulating insulin-induced Akt phosphorylation (2017, NA)
• Network analysis using key molecules in VL pathogenesis (2017, NA)
• IFN-gamma signaling pathway (2017, NA)
• The HCV interactions (both direct and indirect) on the hepatocyte insulin signaling pathway (2017, NA)
• Cryoglobulin (2017, NA)
• Prolonged mechanical loading beyond physiological levels on tenocytes, increases the expression of IL-1B and CCL2 (2017, Homo sapiens)
• Regulatory model of ATX expression in adipose tissue and the biological functions of adipocyte-derived ATX in diet-induced obesity (2017, NA)
• Proposed mechanistic scheme of anticancer activity of peptide extracts from Lentinus squarrosulus in human lung cancer cells (2017, Lentinus squarrosulus,Homo sapiens)
• Reelin's role in stabilizing the cytoskeleton (2017, Mus musculus,Homo sapiens)
• Signaling pathways involved in sarcopenia , (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Bikinia letestui)
• Schematic diagram depicting the KRT19-mediated regulation of NUMB expression, NOTCH signaling pathway and cancer/cancer stem-like cells (CSLC) properties in KRT19-overexpressing breast cancer cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,vectors,Raphanus sativus)
• IDO pathway and inhibitors.Notes: Tryptophan catabolism through the kynurenine pathway involves IDO an intracellular rate limiting enzyme and possible natural and synthetic inhibitors of this enzyme acting through various routes (2017, Solanum tuberosum,Curcuma longa,Carthamus tinctorius,Brassica rapa subsp. pekinensis,Azadirachta indica,Penicillium sp.,Isatis tinctoria,Persicaria tinctoria,Crinum latifolium,Coniochaeta sp.,Mus musculus,Rattus norvegicus,Homo sapiens,Garveia annulata)
• Figure describes the different effects of gut and brain serotonin on the osteoblast (2017, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Location of IL-6 rs1800795 polymorphism and mechanism (2017, Homo sapiens)
• Proteomics Analysis of Ovarian Cancer Cell Lines and Tissues Reveals Drug Resistance-associated Proteins (2017, Homo sapiens)
• Model structure of the MAPK module (2017, NA)
• Acute myeloid leukemia and oncogenic Hedgehog/GLI signaling (2017, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Paraechinus aethiopicus,Antarctothoa delta)
• Molecular regulation of macroautophagy and targets for pharmacological stimulation of the autophagy-lysosomal pathway (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Chenopodium album,Homo sapiens,Adeno-associated virus,Streptomyces hygroscopicus)
• Inflammatory and immune responses to mevalonate pathway dysregulation (2017, NA)
• Metabolic reprogramming associated with immune cell activation engages the mevalonate pathway (2017, NA)
• Interorgan crosstalk involved in Beta-cell failure (2017, NA)
• Schematic model of the S (2017, Spiroplasma eriocheiris,Staphylococcus aureus,Escherichia coli DH5alpha,Anaplasma phagocytophilum,Penaeus vannamei,Penaeus monodon,Procambarus clarkii,Eriocheir sinensis,Macrobrachium rosenbergii,Macrobrachium nipponense,Malacoplasma penetrans,Spiroplasma citri,Spiroplasma sp.,Spiroplasma mirum,Neoaliturus tenellus,Haemaphysalis leporispalustris,Bos taurus,Oryctolagus cuniculus,Capra hircus,Bison bonasus,Saccharomyces cerevisiae,Armoracia rusticana,Zea mays,Mus musculus,Mesocricetus auratus,Homo sapiens,Gallus gallus,vectors,NA)
• SREBP-driven mevalonate pathway (2017, NA)
• PolyI:C induces tumor necroptosis via the TLR3 -TICAM1 pathway (2017, NA)
• Involvement of lncRNAs in the “adenoma-carcinoma sequence”, multi-step model of CRC pathogenesis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,clinical samples,Molva molva,NA)
• How arecoline affects glycolysis and the signaling pathway of anoikis in HA22T/VGH cells (2017, Homo sapiens,Rattus norvegicus,Bos taurus,Chamaeleo chamaeleon)
• PERK-mediated regulation of the mTOR-PI3K-Akt pathway (2017, NA)
• Bacteria-mediated EGR1 induction in host epithelial cells (2017, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli DH5alpha,Salmonella enterica,Porphyromonas gingivalis,Streptococcus pyogenes,Neisseria meningitidis,Limosilactobacillus reuteri,Pseudomonas aeruginosa PAO1,Neisseria gonorrhoeae,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Salmonella enterica subsp. enterica serovar Enteritidis,Ligilactobacillus salivarius,Escherichia coli O111B4,Salmonella enterica subsp. enterica serovar Minnesota,Lactobacillus crispatus,Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344,Neisseria lactamica,Helicobacter pylori J99,Neisseria subflava,Neisseria meningitidis MC58,Streptococcus intermedius,Streptococcus pyogenes str. Manfredo,Limosilactobacillus gastricus,Neisseria gonorrhoeae MS11,Limosilactobacillus antri,Neisseria meningitidis serogroup C,Lactobacillus kalixensis,Lactobacillus ultunensis,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus)
• Working model representing the proposed signaling pathways induced by vitamin D signaling in regulating skeletal muscle mass (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Model depicting the proposed mechanism by which FT-A exert antipyretic effect (2017, NA)
• Intracellular signaling pathways of A7nAchR in anti-inflammatory response (2017, NA)
• Working Figure of the Angiogenesis Pathway Genes (2017, Homo sapiens,Rattus norvegicus,Nicotiana tabacum)
• Canonical and non-canonical NLRP3 inflammasome activation (2017, Escherichia coli,Vibrio cholerae,Citrobacter rodentium,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Mus musculus,Cinchona pubescens,NA)
• Signal transduction pathway of the BCR-ABL fusion gene and Imatinib action (2017, NA)
• Metabolism and transport in endophytic bacterium SA187 (2017, Enterobacter sp.,endophytic bacterium,Enterobacter sp. SA187,Homo sapiens)
• B-cell activating factor (BAFF)-BCR crosstalk in chronic lymphocytic leukemia (CLL) cells (2017, Mus musculus,Bos taurus,Capra hircus,Cricetulus griseus,Homo sapiens)
• Summary of intracellular TLR4 signalling in platelets (2017, NA)
• Summary of intracellular TLR4 signalling pathways in nucleated cells (2017, NA)
• Major signaling pathways in chemoresistance and PDK1 implication (2017, NA)
• An overview of signaling cascades involved in PLK1-induced EMT (2017, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Kynurenine pathway (2017, NA)
• ErbB signaling pathway and its circRNA-related genes (2017, NA)
• DAB2IP in TNFA signaling: activation of ASK1/JNK (2017, NA)
• DAB2IP inhibits RAS-dependent signaling (2017, NA)
• Pathway map for selected proteins encoded by genes that were upregulated in baseline systemic juvenile idiopathic arthritis (SJIA) samples (2017, NA)
• Canonical Rho signaling pathways were identified in a phosphoproteomics screen of HIV-1 signaling via CD4 and CCR5 (2017, Human immunodeficiency virus 1,Influenza A virus,Human immunodeficiency virus,Human gammaherpesvirus 8,Human immunodeficiency virus 2,Homo sapiens,Matthiola incana)
• Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity (2017, Rattus norvegicus,Homo sapiens)
• Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials (2017, Homo sapiens,Mus musculus)
• Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana (2017, NA)
• Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway (2017, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Ovis aries,Saussurea costus,Dillenia suffruticosa,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• HO/CO signaling pathway (2017, NA)
• Novel strategies to prevent the development of multidrug resistance (MDR) in cancer (2017, NA)
• Possible mechanism of connexin responses associated with acute exposure to fatty acids (FAs) (2017, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Hylobates sp.,Xenopus laevis)
• Schematic summary (2017, NA)
• Scheme of the interaction between the intrinsic apoptosis, autophagy and stress response pathways governing the HepG2 response to CdS QDs (2017, Saccharomyces cerevisiae,Bos taurus,Escherichia coli,Sus scrofa,Diaporthe sclerotioides,Pseudomonas aeruginosa MSH3,Homo sapiens,Mus musculus,unidentified,Calloplesiops altivelis)
• Genomes of Fasciola hepatica from the Americas Reveal Colonization with Neorickettsia Endobacteria Related to the Agents of Potomac Horse and Human Sennetsu Fevers (2017, Fasciola hepatica,Homo sapiens)
• Transcriptome Sequencing Reveals Key Pathways and Genes Associated with Cisplatin Resistance in Lung Adenocarcinoma A549 Cells (2017, Homo sapiens,Bos taurus)
• Quiescent and/or self-renewing stem cells display low levels of ROS due to their basal metabolism associated to an efficient antioxidant machinery (2017, Mus musculus,Rattus norvegicus,Bos taurus,Symphonia globulifera,Equus asinus x Equus caballus,Morchella esculenta,Homo sapiens)
• Type I interferon pathway gene network predicted by IPA analysis (2017, NA)
• Schematics of multitargeted actions of T1AM on metabolic and steroidogenic pathways (2017, Candida dubliniensis,Sesamum indicum,Rubus occidentalis,Homo sapiens,Mus musculus,Cavia porcellus,Macaca mulatta,Leptospira kmetyi)
• Representation showing the mutations associated with the RAS/RAF/MEK/ERK pathway observed in melanoma (2017, NA)
• Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45 (2017, NA)
• Proposed model for the role of GAS6 in maintaining oral mucosal homeostasis (2017, Mus musculus,Homo sapiens)
• GA13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3Beta-NFATc1 signalling pathway (2017, NA)
• Exome and genome sequencing of nasopharynx cancer identifies NFKB pathway activating mutations (2017, NA)
• Schematic working hypothesis (2017, NA)
• Proposed mechanisms involved in in vitro anticancer activity of surfactin (2017, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Bacillus subtilis,Listeria monocytogenes,Bacillus subtilis At2,Salmonella enterica subsp. enterica serovar Typhi,Bacillus amyloliquefaciens,Bacillus licheniformis,Bacillus sp. in firmicutes,Bacillus subtilis subsp. subtilis,Bacillus pumilus,Bacillus subtilis subsp. natto,Bacillus velezensis At1,Niallia circulans,Brevibacillus brevis,Bacillus sp. B,Bacillus mojavensis,Bacillus sp. KB3.1,Helianthus annuus,Aspergillus niger,Sesamum indicum,Penicillium sp.,Rhizopus stolonifer,Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,uncultured marine bacterium)
• The unique biochemical aspects of MET-mediated bypass signaling driven by cell surface RTK aggregates leading to de-coupling of EGFR oncogenic function from its tyrosine kinase activity (alternate signaling) (2017, Homo sapiens)
• Jellyfish extract induces apoptotic cell death through the p38 pathway and cell cycle arrest in chronic myelogenous leukemia K562 cells (2017, Aequorea victoria,Rhopilema esculentum,Aurelia aurita,Stomolophus meleagris,Nemopilema nomurai,Armoracia rusticana,Matthiola incana,Homo sapiens,Bos taurus)
• SMYD3 as a new enhancer in Ras-driven cancers via its cytoplasmic functions (2017, NA)
• Oncogenic pathways in glioma and possibilities for pharmacological interventions, relevant for the models described in this article (2017, Bos taurus,Oryctolagus cuniculus,Gallus gallus,Danio rerio,Canis lupus familiaris,Turdus migratorius,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Avian leukosis virus)
• UPR activation in the spinal cord from an X-ALD mouse model (2017, NA)
• Illustration of L (2017, NA)
• Integrin-linked kinase (ILK) signaling pathway is altered following RVFV infection (2017, Rift Valley fever virus,Homo sapiens)
• PPI network for the DEGs (2017, NA)
• First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms (2017, NA)
• Mechanisms by which alteration of normal miRNA profiles can occur, leading to aberrant miRNA profiles in childhood solid tumours (2017, NA)
• Replication Stress Response in Mammals and Trypanosomatids (2017, NA)
• Nesfatin-1 protects dopaminergic neurons against MPP+/MPTP-induced neurotoxicity through the C-Raf–ERK1/2-dependent anti-apoptotic pathway (2017, NA)
• Model depicting roles of Sufu in chaperoning Gli functions during Shh signaling (2017, NA)
• General overview of the process of cell death in SMA (2017, NA)
• Schematic presentation of suggested pathways of PTEN involvement in neuronal survival (2017, NA)
• NFKB in the regulation of NLRP3 inflammasome (2017, NA)
• ZIP-mediated signaling pathways promote cell proliferation and metastasis in luminal and tamoxifen-resistant breast cancer cells (2017, Mus musculus,Rattus norvegicus,Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Homo sapiens,Danio rerio,prion,Aspergillus niger)
• Zinc deficiency in prostate cancer cells promotes cell survival via a phosphoinositide 3-kinase (PI3K) signaling pathway (2017, Mus musculus,Rattus norvegicus,Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Homo sapiens,Danio rerio,prion,Aspergillus niger)
• Scheme of PI3K pathway with candidate regulators of mTORC2 colored in green (2017, NA)
• Redox regulation of cell mobility (2017, NA)
• Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation (2017, NA)
• Predicting Drug Combination Index and Simulating the Network-Regulation Dynamics by Mathematical Modeling of Drug-Targeted EGFR-ERK Signaling Pathway (2017, Homo sapiens,Mus musculus)
• The mechanisms by which PRRSV infection upregulated miR-373 expression and miR-373 facilitated PRRSV replication (2017, Sus scrofa,Porcine reproductive and respiratory syndrome virus,Homo sapiens)
• Suggested model scheme of the c-Src signaling pathway being induced and hijacked by IBDV to facilitate its infectious entry (2017, Gallus gallus,Infectious bursal disease virus,Homo sapiens)
• Part of the metabolism of M (2017, Methylorubrum extorquens AM1,Leptospira kmetyi,Kyrpidia tusciae,Robertmurraya massiliosenegalensis JC6,Kyrpidia tusciae DSM 2912)
• Redox regulation of cell–cell junctions (2017, NA)
• Activation and regulation of complement pathways relevant to Borrelia spp (2017, Borrelia miyamotoi,Homo sapiens)
• Simplified signaling pathway network where Wnt/Beta-catenin, Notch and Hedgehog pathways, along with critical transcription factors including Bmi-1, c-myc, Slug and Sox9, interact with one another and contribute to the maintenance of MaSC state (2017, NA)
• Dysregulation of KRAS signaling pathway in PDAC tumors compared with that in the paired adjacent non-malignant tissues (2017, NA)
• 10H-3,6-Diazaphenothiazine induces G2/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NFKB and (BIRC6-XIAP) complexes (2017, Mus musculus,Rattus norvegicus,Oplegnathus fasciatus,Abramis brama,Homo sapiens,Bos taurus)
• Proposed model for OPG signalling events driving PAH pathogenesis (2017, NA)
• Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1 (2017, NA)
• Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial (2017, NA)
• Role of glycolysis in NPC self-renewal (2017, Mus musculus,Homo sapiens)
• Crosstalk between cancer and cancer stem cell-related pathways (2017, NA)
• Hippo pathway in mesothelioma cells (2017, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Lareunionomyces loeiensis,clinical samples)
• Molecular Characterization of Pediatric Restrictive Cardiomyopathy from Integrative Genomics (2017, Candida dubliniensis,Ficus racemosa,Homo sapiens,Mus musculus)
• Negative regulation of TLR4 signaling by BCAP and PLCG2 (2017, Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli BL21DE3,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus,Gallus gallus,Tobacco etch virus)
• Suggested mechanism of EtSCT action in CCl4-induced hepatic injury (2017, Styela clava,Homo sapiens)
• Several signalling pathways can induce epithelial-mesenchymal transition in pancreatic cancer cells for example Notch, transforming growth factorB, Midkine, hypoxia-inducible factor-1A and tumor necrosis factorA (2017, Homo sapiens,Mus musculus)
• Systemic complement in metabolism (2017, Gallus gallus,Danio rerio,Gnathostomata,Vertebrata,Cyclostomata,Myxine glutinosa,Paracentrotus lividus,Amoebozoa,Bilateria,Amphimedon queenslandica,Eumetazoa,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Candida albicans,Pseudomonas aeruginosa,Human immunodeficiency virus,Measles morbillivirus,Borreliella burgdorferi,Homo sapiens,Mus musculus)
• Autocrine and intracellular complement activation (2017, Gallus gallus,Danio rerio,Gnathostomata,Vertebrata,Cyclostomata,Myxine glutinosa,Paracentrotus lividus,Amoebozoa,Bilateria,Amphimedon queenslandica,Eumetazoa,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Candida albicans,Pseudomonas aeruginosa,Human immunodeficiency virus,Measles morbillivirus,Borreliella burgdorferi,Homo sapiens,Mus musculus)
• Mycobacterium tuberculosis interferes with phagosome maturation (2017, NA)
• Scheme of magnesium and calcium transporters and their interaction in the AD brain (2017, NA)
• Proteostasis network via the HSF1-SQSTM1 axis (2017, NA)
• Evolutionary history of the PTH family in vertebrates (2017, NA)
• Phylogenetic and conserved synteny analysis of PTH related proteins (2017, NA)
• Model describing the copper transport system and its association with AD (2017, NA)
• JNK signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Simplified diagram shows our current understanding of the role of insulin and curcumin on hepatic lipogenesis (2017, NA)
• Cell fate decision by poly(ADP-ribosyl)ation in NSPCs (2017, NA)
• Crosstalk of KDG molecular and network pathways (2017, NA)
• NRF2 as a hub connecting proteotoxic-derived emergency signals to a protective transcriptional response (2017, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,prion,Angelica sinensis)
• Integration of non-genomic signaling and canonical signaling of androgen receptor (AR) (2017, NA)
• Complement activation (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Dexamethasone (Dex) and monphosphoryl lipid A (MPLA) treatment leads to changes in the expression of genes involved in biological processes associated with immune response regulation (2017, NA)
• Omega-6- and omega-3-derived lipid mediators (2017, NA)
• Invariant natural killer T (iNKT) cell-mediated immune surveillance of blood cancer and counteractive evasion strategies utilized by blood cancer cells (2017, NA)
• Representative simplified scheme summarizing the main findings discussed (2017, NA)
• Effector cytokines can stimulate transcription of proinflammatory signals through the Janus kinase–signal transducers and activators of transcription (JAK-STAT) signalling pathway (2017, Human alphaherpesvirus 3,Human parvovirus B19,Homo sapiens,Mus musculus,NA)
• miR-22 services as onco-miRNA to promote tumor malignant transformation (2017, Homo sapiens,Mus musculus,Hepatitis B virus,Platycodon grandiflorus,NA)
• A schematic representation of a truncated transsulphuration pathway in malaria parasite: Absence of CBS and CGL enzymes results in a truncated transsulphuration (TS) pathway in the parasite (2017, NA)
• Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptorA in myocardial infarction-induced cardiac fibrosis (2017, NA)
• PI3K/Akt/mTOR pathway involved in tumorigenesis and metastasis (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanism of UA-induced inflammation in endothelial cell (2017, NA)
• Summary of three key signaling cascades that may mediate the link between inflammation and epileptogenesis (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Deptor depletion is associated with different pathway (2017, NA)
• PDGF signaling pathway (2017, Gallus gallus,Danio rerio,Coturnix coturnix,Anser sp.,Phasianus colchicus,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Plasmid pTF1)
• LPS/TLR4 engagement promotes AMPK dephosphorylation and decreased kinase activity in peritoneal macrophages (2017, Homo sapiens,Mus musculus)
• Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway (2017, NA)
• Terpene biosynthetic pathway, and heatmaps displaying the expression (log2 FPKM) of enzymes involved in the different reaction steps (2017, Arabidopsis thaliana,Solanum lycopersicum,Diaporthe sclerotioides,Embryophyta,Vitis vinifera,Theobroma cacao,Musa acuminata,Ipomoea batatas,Ricinus communis,Citrus sinensis,Antirrhinum majus,Withania somnifera,Jatropha curcas,Azadirachta indica,Lolium arundinaceum,Mentha spicata,Cucurbita pepo,Pelargonium x hortorum,Pelargonium graveolens,Pelargonium capitatum,Pelargonium tetragonum,Pelargonium echinatum,Pelargonium radens,Pelargonium transvaalense,Pelargonium incrassatum,Pelargonium myrrhifolium,Pelargonium cotyledonis,Pelargonium exstipulatum,Pelargonium nanum,Pelargonium citronellum,Pelargonium dichondrifolium,Pelargonium fulgidum,Pelargonium endlicherianum,Leptinotarsa decemlineata,Physarum roseum,Homo sapiens,Mus musculus,Triportheus paranensis)
• Calcium movement into the mammary gland regulates maternal calcium homeostasis during lactation (2017, NA)
• Canonical UPR pathway (2017, Bos taurus,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• PTEN signaling in Treg cells (2017, NA)
• Regulation of KLFs in ECs (2017, NA)
• HCMV-encoded agonists of the NFKB signaling pathway (2017, Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Measles morbillivirus,Murid betaherpesvirus 1,Human alphaherpesvirus 3,Murid gammaherpesvirus 4,Human rotavirus,Ectromelia virus,Homo sapiens,NA,NA,NA)
• HCMV-encoded antagonists of the NFKB signalling pathway (2017, Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Measles morbillivirus,Murid betaherpesvirus 1,Human alphaherpesvirus 3,Murid gammaherpesvirus 4,Human rotavirus,Ectromelia virus,Homo sapiens,NA,NA,NA)
• Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense (2017, NA)
• Working model for early events occurring in premutation neurons (2017, Mus musculus,Homo sapiens)
• Relationship between lipids and hedgehog signaling (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Paraechinus aethiopicus)
• Diagram of genes in the PI3K/AKT signaling pathway (2017, NA)
• Proposed scheme for the role of BMSCs in modulation of p53-miRNA interaction in association with stroma-induced drug resistance in MM (2017, Homo sapiens,Mus musculus)
• Biosynthetic pathways for BLFL production (2017, NA)
• Schematic overview of gene expression within a DR1 cell in the presence of TRI (2017, Acinetobacter oleivorans)
• Sustained kidney biochemical derangement in treated experimental diabetes: a clue to metabolic memory (2017, NA)
• CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension (2017, NA)
• Transmembrane ion transport proteins and mechanisms thought to be involved in the regulatory volume decrease (RVD) of sperm (2017, Mus musculus,Cavia porcellus,Cricetus cricetus,Homo sapiens,Bos taurus,PX clade,unidentified,Paracentrotus lividus)
• PI3K/Akt/mTor pathway and effects of mTOR-inhibitors (2017, NA)
• Brominated indoles from a marine mollusc inhibit inflammation in a murine model of acute lung injury (2017, NA)
• MCF7-specific signaling pathway network inferred by TILP model (2017, Homo sapiens,prion)
• MCF7-related generic pathway map (2017, Homo sapiens,prion)
• Regulation of the intrinsic pathway to apoptosis by B‐cell‐lymphoma‐2 (BCL2) family members (2017, NA)
• Interplay in the synthesis and actions of the 2-acylglycerols and ethanolamides derived from ARA, DHA and EPA (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta)
• Proximal components of the TNF signaling pathway (2017, NA)
• This schematic diagram depicts the signaling pathways that possibly drive BAVM pathology (2017, NA)
• Genes affected concordantly within the ileum and meta-analysis data sets formed biofunctional clusters of overlapping pathways (2017, Pseudomonas aeruginosa,Bacillus anthracis,Candidatus Arthromitus sp. SFB-mouse,Pseudomonas aeruginosa BL10,Beijerinckia mobilis,gut metagenome,metagenome,human metagenome,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Lavandula angustifolia,Ficus racemosa,Homo sapiens,Sus scrofa,NA)
• Intraset concordancy and transcriptome-proteome discordancy of gene products related to protein translation, OxP, and chaperone proteins (2017, Pseudomonas aeruginosa,Bacillus anthracis,Candidatus Arthromitus sp. SFB-mouse,Pseudomonas aeruginosa BL10,Beijerinckia mobilis,gut metagenome,metagenome,human metagenome,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Lavandula angustifolia,Ficus racemosa,Homo sapiens,Sus scrofa,NA)
• The antigen presentation pathway was downregulated in the GF mice (2017, Pseudomonas aeruginosa,Bacillus anthracis,Candidatus Arthromitus sp. SFB-mouse,Pseudomonas aeruginosa BL10,Beijerinckia mobilis,gut metagenome,metagenome,human metagenome,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Lavandula angustifolia,Ficus racemosa,Homo sapiens,Sus scrofa,NA)
• Mechanisms underlying SQ induced self-renewal (2017, Oryctolagus cuniculus,Equus caballus,Psidium guajava,Galatella linosyris,Homo sapiens,Mus musculus)
• Proposed pathway for GBGamma-induced TE retraction (2017, NA)
• Possible roles of lncRNAs played in the context of RNA-RNA interactions (2017, NA)
• Hypothesis of intercellular energy relocation triggered by gut microbiota (2017, NA)
• Intracellular energy relocation in fat body cell of Drosophila and immune cell of human (2017, NA)
• Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring (2017, Saccharomyces cerevisiae,Eucalyptus intertexta,Saccharomyces cerevisiae IR-2,Mus musculus,Rattus norvegicus,Homo sapiens,Rat sarcoma virus)
• GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary (2017, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Caenorhabditis elegans)
• Signaling networks in aging (2017, Saccharomyces cerevisiae,Zea mays,Glycine max,Solanum lycopersicum,Triticum aestivum,PX clade,Malus domestica,Olea europaea,Panax ginseng,Curcuma longa,Agaricus bisporus,Camellia sinensis,Fragaria x ananassa,Allium cepa,Theobroma cacao,Allium sativum,Daucus carota,Ginkgo biloba,Punica granatum,Scutellaria baicalensis,Sesamum indicum,Panax notoginseng,Cinnamomum verum,Tripterygium wilfordii,Astragalus membranaceus,Angelica sinensis,Origanum vulgare,Litchi chinensis,Polygonum cuspidatum,Ziziphus jujuba,Nigella sativa,Humulus lupulus,Azadirachta indica,Pinus sylvestris,Rehmannia glutinosa,Ophiopogon japonicus,Phyllanthus emblica,Astragalus mongholicus,Vigna angularis,Eleutherococcus senticosus,Toxicodendron vernicifluum,Viscum album,Abies grandis,Arctium lappa,Rosa x damascena,Platycladus orientalis,Talaromyces funiculosus,Larrea tridentata,Bletilla striata,Daucus carota subsp. sativus,Plumbago zeylanica,Pinus densiflora,Viscum coloratum,Cynomorium songaricum,Agrocybe cylindracea,Sargassum sagamianum,Phellinus sp.,Dicliptera chinensis,Porphyra rosengurttii,Celastrus monospermus,Damnacanthus officinarum,Incarvillea younghusbandii,Sasa senanensis,Collema cristatum,Aralia chinensis,Chondrodendron tomentosum,Cynanchum otophyllum,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Triportheus paranensis,Opsanus beta,Apis mellifera,Tenebrio molitor,Megalobrama amblycephala,Brachionus sp. Manjavacas,Nothobranchius guentheri,Mus musculus,Rattus norvegicus,Homo sapiens,unidentified granulovirus,NA)
• Transcriptional response to H2O2 or diamide (and Cd) and the stress induced nuclear localization of Oxs1 (2017, Schizosaccharomyces pombe,Homo sapiens)
• Proposed model for the role INPP5E plays at cilia (2017, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Candida albicans,Homo sapiens,Mus musculus,Canis lupus familiaris,unidentified)
• Update on the therapeutic significance of estrogen receptor beta in malignant gliomas (2017, NA)
• Role of growth differentiation factor 11 in development, physiology and disease (2017, NA)
• Processing and presentation of MHC class I and II restricted antigens for CD8+ and CD4+ T cell recognition, respectively (2017, NA)
• Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10 (2017, NA)
• Methodology for Cancer Therapeutics by Systems Pharmacology-Based Analysis: A Case Study on Breast Cancer-Related Traditional Chinese Medicines (2017, NA)
• Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus (2017, NA)
• CIL-102-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells via Upregulation of p21 and GADD45 (2017, NA)
• MEF2 signaling and human diseases (2017, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 4)
• MEF2 signaling and human diseases (2017, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 4)
• The experimental design for iTRAQ proteomic analysis (2017, NA)
• Loss of Axin2 can cause MVD by shifting TGFB/SMAD3 pathway toward WNT/Beta-catenin and BMP signaling (2017, NA)
• Progression of traumatic brain injury (2017, Homo sapiens)
• Resveratrol has multiple biological functions that are relevant for AD (2017, NA)
• Resistance to BRAF inhibitors can occur through stromal extracellular signals (blue) leading to ERK reactivation upstream of MEK (orange) or to enhanced survival signaling(green) (2017, Homo sapiens)
• PD1-dependent inhibitory mechanisms (2017, Homo sapiens)
• Jak/STAT pathway (2017, NA)
• PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways (2017, NA)
• Hedgehog signaling pathway (2017, NA)
• Wnt signaling pathway (2017, NA)
• Notch signaling pathway (2017, NA)
• Wnt Signaling Prevents the AB Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons (2017, NA)
• Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer (2017, Homo sapiens)
• Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer (2017, Homo sapiens)
• Regulation of Cellular Redox Signaling by Matricellular Proteins in Vascular Biology, Immunology, and Cancer (2017, Homo sapiens)
• c-Myc phosphorylation and degradation in normal vs. cancer cells (2017, NA)
• Proposed working model of ZZR on the Hedgehog signaling pathway-mediated MDR in colorectal cancer cells (2017, herbal medicine,Engelhardia roxburghiana,Rheum officinale,Actinidia arguta,Cyperus rotundus,Salvia chinensis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Equus asinus)
• Chromosomal instability and acquired drug resistance in multiple myeloma (2017, Homo sapiens,Mus musculus)
• STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1A/VEGF signaling pathway (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Gallus gallus)
• Targeting the HGF/c-MET pathway: stromal remodelling in pancreatic cancer (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Glycine max)
• Somatic mutations in salivary duct carcinoma and potential therapeutic targets (2017, NA)
• HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles (2017, Diaporthe sclerotioides,Piromyces finnis,Homo sapiens,Mus musculus)
• Cyclin D–CDK4/6–INK4–Rb pathway and cell cycle control (2017, Diaporthe sclerotioides,Piromyces finnis,Homo sapiens,Mus musculus)
• Schematic representations of melatonin-dependent regulation of BAPP processing secretases and its possible underlying mechanisms (2017, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Ovis aries,Mesocricetus auratus,Drosophila melanogaster,Paramecium tetraurelia,Homo sapiens,Turdus migratorius)
• PTP4A1 promotes TGFB signaling in DFs (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Zea mays,Bacillus subtilis At2,Escherichia coli BL21DE3,Homo sapiens,Mus musculus)
• Schematic diagram of adiponectin-mediated thermogenic regulation in brown and “beige” adipocytes (2017, NA)
• Co-expression network between DEGs and DELs in HCC (2017, NA)
• Systematic model showing the operational hierarchy of signaling pathways in wheat leaf cells that counter the effects of drought stress (2017, NA)
• TLR signaling is redox-regulated (2017, NA)
• Differentially expressed genes involved in glycolysis, the TCA cycle, pyruvate metabolism, amino acid biosynthesis and the putrescine biosynthetic pathway (2017, Corynebacterium glutamicum)
• Simplified scheme of innate immune recognition mediated by PRRs (2017, NA)
• Hypothetical signaling network integrating top genes identified through Rasch analysis (2017, Homo sapiens,Mus musculus,prion)
• Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients’ survival (2017, NA)
• Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death (2017, Vesicular stomatitis virus,Vaccinia virus,Encephalomyocarditis virus,ssRNA viruses,Cowpox virus,Ectromelia virus,Rabbit fibroma virus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Dipnomorpha)
• Dual roles of yes-associated protein (YAP) in colorectal cancer (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Polyomavirus sp.)
• Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model (2017, NA)
• Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease (2017, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways (2017, Malus domestica,Cucumis sativus,Fragaria x ananassa,Allium cepa,Toxicodendron vernicifluum,Kadsura longipedunculata,Homo sapiens,Rattus norvegicus,Bos taurus)
• ARE gene product interactome (2017, Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• JNK activation is essential for activation of MEK/ERK signaling in IL-1Beta-induced COX-2 expression in synovial fibroblasts (2017, NA)
• Genomics of Apicomplexan Parasites (2017, Plasmodium falciparum,Venustaconcha ellipsiformis,Toxoplasma gondii,Trypanosoma brucei,Plasmodium berghei,Plasmodium vivax,Cryptosporidium parvum,Plasmodium yoelii,Plasmodium chabaudi,Alveolata,Plasmodium knowlesi,Neospora caninum,Eimeria tenella,Theileria parva,Theileria annulata,Cryptosporidium hominis,Plasmodium falciparum HB3,Cryptosporidium muris,Plasmodium cynomolgi,Hammondia hammondi,Sarcocystis neurona,Sarcocystis hominis,Escherichia coli,Mycobacterium tuberculosis,Campylobacter jejuni,Saccharomyces cerevisiae,PX clade,prion,transposons,Homo sapiens,Mus musculus,Bos taurus)
• Mitonuclear gene groups associated with disease in GWAS are significantly enriched for protein–protein interactions (2017, Vasconcellea candicans,Ficus racemosa,Homo sapiens)
• Showing a putative Th17/Treg/Th1/Th2 regulatory axis (2017, NA)
• Comparison of RIG-I-like receptor (RLR) pathways in humans and zebrafish (2017, NA)
• Cross-regulation between interleukin-1 (IL-1) and type-1 interferon (IFN) inflammatory pathways as exemplified during Mtb infection (2017, Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Salmonella enterica,Streptococcus pyogenes,Bacillus anthracis,Shigella flexneri,Chlamydia trachomatis,Francisella tularensis,Mycobacterium avium,Legionella pneumophila,Francisella tularensis subsp. novicida,Mycobacterium tuberculosis HN878,Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Nakaseomyces glabratus,Histoplasma capsulatum,Cryptococcus gattii VGIII,Candida albicans 28A,Human immunodeficiency virus 1,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Trypanosoma cruzi,Leishmania major,Plasmodium yoelii,Plasmodium chabaudi,Homo sapiens,Mus musculus,NA,NA)
• Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program (2017, NA)
• Interaction map representing CNV-altered genes enriched in GO classes and grouped on the basis of their main biological processes (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Ahlbergia korea)
• Schematic overview of glycolysis and the fates of pyruvate in Streptococcus pneumoniae D39 (serotype 2) (2017, Streptococcus pneumoniae,Streptococcus pneumoniae D39,Homo sapiens)
• Proposed renoprotective mechanisms in diabetic nephropathy (DN) through adenosine monophosphate-activated protein kinase (AMPK) activation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Cell‐intrinsic pathway of apoptosis (2017, NA)
• Regulation of DRP1 and mitochondrial fission by ERK1/2 signalling (2017, NA)
• Photoperiodic regulation of FT expression by CO, and FT protein movement (2017, Arabidopsis thaliana)
• KEGG pathway maps for (A) non-small cell lung cancer (hsa05223) and (B) EGFR tyrosine kinase inhibitor resistance (hsa01521) (2017, metagenome,metagenomes,Homo sapiens,Nocardioides sp. JS614)
• An example of activating crosstalk (2017, Homo sapiens,Mus musculus,Gallus gallus)
• Insulin signaling pathway is significantly enriched in human cycling genes (the hypergeometric test, p-value = 9.70E-7, E-ratio = 2.26) (2017, NA)
• Current model of CW entry and signaling (2017, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Human papillomavirus type 16,Vaccinia virus,Ebola virus sp.,adeno-associated virus 2,Echovirus E1,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pneumoniae,Escherichia coli O111B4,Streptococcus pneumoniae R6,Saccharomyces cerevisiae,Armoracia rusticana,Triticum aestivum,Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Gallus gallus,NA)
• Gene regulatory network (GRN) inferred for members from the TP53 pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Relationship between alginate biosynthesis and the cellular metabolism in P (2017, NA)
• Working hypothesis of the mechanism through which different miRNAs regulate the PTEN pathway, PI3K/AKT and STAT signalling in sperm (2017, Bos taurus,Capra hircus,Ovis aries,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,Psidium guajava)
• Gene regulatory network (GRN) inferred for members from the NFKB pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Metabolic characteristics of P (2017, Paraphotobacterium marinum)
• Role of Platelet-Derived Transforming Growth FactorB1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis (2017, NA)
• Canonical Wnt signaling and bone remodeling (2017, NA)
• FLO-induced cytotoxicity in L cells (2017, NA)
• Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks (2017, NA)
• Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks (2017, NA)
• Artemisinin biosynthetic pathway in A (2017, NA)
• Schematic models for D2R signaling in mPFC SC-projecting projecting L5 pyramidal neurons (2017, Mus musculus,Homo sapiens)
• Current view of the mechanisms responsible for activation and modulation of the reproductive axis in birds and mammals (2017, NA)
• Schematic diagram representing the signaling pathway for BAR-mediated cardiac insulin resistance (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Insulin signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Examples of G protein- and Beta-arrestin-mediated downstream signaling pathways on GPCRs (2017, NA)
• Identification of differentially regulated genes within the cellular assembly and organization, cellular function and maintenance and cell death and survival network (2017, NA)
• The co-expressing network of differentially expressed lncRNAs and mRNAs (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,NA)
• Notch1 signaling pathway in adult rat brain (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens)
• Domain structure of Sina/Siah and its regulation in Drosophila and mammals (2017, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice (2017, Homo sapiens,Mus musculus)
• Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial (2017, NA)
• Effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial (2017, NA)
• Relaxation oscillations and hierarchy of feedbacks in MAPK signaling (2017, Homo sapiens,Dictyostelium discoideum,Turdus migratorius)
• Identification of genetic susceptibility loci for intestinal Behçet’s disease (2017, NA)
• Regulation of Exercise-Induced Autophagy in Skeletal Muscle (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Cheirogaleus major,Icterus cayanensis tibialis,Leptodactylus vastus,Saccharomyces cerevisiae)
• Direct and indirect targeting of the B cell receptor signaling pathway (2017, NA)
• One marker is not enough for designate one cell as cancer stem cell (2017, NA)
• Overall survival mechanism used by the Apicomplexan parasites in different host cells (2017, NA)
• WNT signaling pathway activation (2017, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• KEGG pathway “FOXO signaling pathway” is regulated by let-7 miRNA (2017, Saccharomyces cerevisiae,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli OP50,Saccharomyces cerevisiae CAT-1,Bacopa monnieri,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• let-7c and miR-10b target multiple genes in regulatory networks (2017, NA)
• Cross talk between the transforming growth factor B (TGFB) family and Wnt signaling at multiple points (2017, NA)
• Illustration of the cooperative regulation of a miRNA module that contains four miRNAs: miR-18a-3p, -320a, -193b-3p, and -92b-3p (pink diamonds) (2017, NA)
• Selected metabolic pathways of the putative novel SAOB unFirm02_FrBGR cluster 2 (2017, Coprothermobacter proteolyticus)
• De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance (2017, Homo sapiens,Mus musculus)
• A classical example of GPCR signaling pathway (2017, NA)
• cGMP, phosphodiesterase 5 (PDE5), sildenafil, and melanoma growth (2017, NA)
• Agents that affect the Hippo pathway (Nat Rev Cancer (2017, NA)
• Indirect ablative damage triggers apoptotic cell death and does not induce co-stimulator expression on DCs (2017, NA)
• NAFLD related lipotoxicity, IR and inflammation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Schematic diagram depicting the possible molecular mechanisms by which mitoQ prevents renal tubular cell injury by maintaining mitochondrial integrity under HG conditions (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• BR signaling pathway (2017, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Triticum aestivum,Hordeum vulgare,Brassica napus,Nicotiana benthamiana,Vicia faba,Brachypodium distachyon,Alternaria brassicicola,Erythrina poeppigiana,Fusarium culmorum,Lotus tenuis,Pythium graminicola,Pseudomonas syringae,Pseudomonas syringae pv. tomato str. DC3000,Tobacco mosaic virus)
• Cross-talk between BR and drought pathways (2017, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Triticum aestivum,Hordeum vulgare,Brassica napus,Nicotiana benthamiana,Vicia faba,Brachypodium distachyon,Alternaria brassicicola,Erythrina poeppigiana,Fusarium culmorum,Lotus tenuis,Pythium graminicola,Pseudomonas syringae,Pseudomonas syringae pv. tomato str. DC3000,Tobacco mosaic virus)
• HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes (2017, NA)
• Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency (2017, Human alphaherpesvirus 1,Human papillomavirus,Ebola virus,Enterovirus C,Saccharomyces cerevisiae,Solanum lycopersicum,Saccharomyces cerevisiae PE-2,Homo sapiens,Mus musculus,Sus scrofa)
• Roles of nucleus PRDX1 in the H2O2‐induced apoptosis (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bifidobacterium longum subsp. infantis)
• Proposed working model by which boehmenan exerted anti-proliferative activities in A431 cells (2017, NA)
• Effect of 1,25(OH)2D3 and AB on the key reactions involved in the sphingolipid metabolic pathway (2017, NA)
• Schematics of the Wnt/Beta-catenin signalling pathway (2017, Mus musculus,Homo sapiens)
• Pathways significantly enriched for: (A) Loci associated with the vertical cup-disc ratio, cup area and intraocular pressure (P-value <7.0 × 10-6 in the GWAS) (2017, Danio rerio,Homo sapiens)
• Macrophage response to cpsA deletion (2017, NA)
• Higher-resolution version of with gene target names visible (2017, NA)
• Systems biology analysis of longitudinal functional response of endothelial cells to shear stress (2017, NA)
• Role of PLZF as a tumor suppressor in prostate cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• miR-708-5p: a microRNA with emerging roles in cancer (2017, NA)
• RGS19 upregulates Nm23-H1/2 metastasis suppressors by transcriptional activation via the cAMP/PKA/CREB pathway (2017, NA)
• HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma (2017, NA)
• Insulin signalling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Metabolic reprogramming in cancer cells under hypoxia (2017, NA)
• Cell signaling pathway scheme of metabolic alterations due to Zika virus infection (2017, NA)
• Diagram illustrating damage processes and pathways thought to contribute to HC loss due to acoustic overexposure (2017, NA)
• Leptomeningeal disease: current diagnostic and therapeutic strategies (2017, Homo sapiens)
• S100A4 in cancer progression and metastasis: A systematic review (2017, Homo sapiens)
• Single-cell genomic analysis of head and neck squamous cell carcinoma (2017, NA)
• Genome-wide functional analysis on the molecular mechanism of specifically biosynthesized fluorescence Eu complex (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• FOXO1 regulates activation and function of dendritic cells (2017, Homo sapiens,Mus musculus,Drosophila melanogaster,Porphyromonas gingivalis)
• Pulmonary transcriptomic responses indicate a dual role of inflammation in pneumonia development and viral clearance during 2009 pandemic influenza infection (2017, Influenza A virus,unidentified influenza virus,H1N1 subtype,H5N1 subtype,H7N9 subtype,Influenza A virus H3N2,Swine influenza virus,Bos taurus,Canis lupus familiaris,Sus scrofa,Mustela putorius furo,Homo sapiens,Mus musculus,Sequoia sempervirens)
• TGFB superfamily signaling and its involvement in decidualization (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Simplified scheme of liver architecture and Wnt/ Beta-catenin signalling (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,unidentified)
• Schematic diagram showing the observed changes induced by HCV in endoglin-associated cell signaling pathways (2017, NA)
• Chlorophyll metabolic pathway in drought-stress grapevine leaves (2017, NA)
• Schematic overview of initial glucose metabolism in yeast and its connection to activation of the Ras-cAMP-PKA pathway (2017, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Capra hircus,Escherichia coli BL21,Escherichia coli FBP1,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Human papillomavirus type 16)
• Rationale for the problematic role of B2 adrenergic agonists in clinical trials (2017, NA)
• The RTK signaling network and nodes of therapeutic blockade (2017, NA)
• NFKB signaling pathway (2017, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Lareunionomyces loeiensis)
• Agents with potential synergistic activity with midostaurin in AML (2017, NA)
• Summary of the study results with pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• AKT signaling pathway map (2017, NA)
• Regulated Proteolytic Processing of Human Beta-Amyloid Precursor Protein and the Resulting Cleavage Fragments.(A) Schematic diagram of human Beta-amyloid precursor protein (APP) (2017, NA)
• Different endothelial responses to different patterns of flow (2017, NA)
• De novo transcriptome sequencing of Isaria cateniannulata and comparative analysis of gene expression in response to heat and cold stresses (2017, Saccharomyces cerevisiae,Oryza sativa,Solanum tuberosum,Schizosaccharomyces pombe,Aspergillus fumigatus,Aspergillus nidulans,Neurospora crassa,Aspergillus terreus,Beauveria bassiana,Cordyceps militaris,Metarhizium anisopliae,Neopyropia yezoensis,Chrysanthemum indicum,Rhizophagus intraradices,Trichoderma virens,Aspergillus fischeri,Anthurium andraeanum,Metarhizium acridum,Metarhizium robertsii,Scedosporium apiospermum,Blastocladiella emersonii,Cordyceps cateniannulata,Tetranychus urticae,Adoxophyes honmai,Homo sapiens,Cyprinus carpio haematopterus)
• Mongersen, tofacitinib, filgotinib: mechanisms of action (2017, NA)
• Proposed model for impaired apoptotic response to hMPV infection in NECs from asthmatics (2017, NA)
• Mechanisms involved in vitamin D-mediated immunomodulation of neutrophils (2017, Homo sapiens,Streptococcus pneumoniae)
• Complement cascades (2017, NA)
• Proposed working model: POPX2 regulates the TAK1-IKK-NFKB pathway during DNA-damage-induced apoptosis (2017, Bos taurus,Oryctolagus cuniculus,Cervus elaphus,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Apoptotic molecular signaling pathway (2017, Armoracia rusticana,Diaporthe sclerotioides,Zingiber officinale,Homo sapiens,Bos taurus)
• Modules for cofactor balancing and phosphorylation (2017, Escherichia coli,Thermus thermophilus,Thermotoga maritima,Levilactobacillus brevis,Stutzerimonas stutzeri,Lactiplantibacillus pentosus,Thermosynechococcus vestitus BP-1,Thermobifida fusca YX,Anaerocolumna aminovalerica,Ralstonia sp. 4506,Homo sapiens)
• Modules for chemical production from pyruvate and acetyl CoA (2017, Escherichia coli,Thermus thermophilus,Thermotoga maritima,Levilactobacillus brevis,Stutzerimonas stutzeri,Lactiplantibacillus pentosus,Thermosynechococcus vestitus BP-1,Thermobifida fusca YX,Anaerocolumna aminovalerica,Ralstonia sp. 4506,Homo sapiens)
• Cyclic modules for conversion of glucose and other carbon source (2017, Escherichia coli,Thermus thermophilus,Thermotoga maritima,Levilactobacillus brevis,Stutzerimonas stutzeri,Lactiplantibacillus pentosus,Thermosynechococcus vestitus BP-1,Thermobifida fusca YX,Anaerocolumna aminovalerica,Ralstonia sp. 4506,Homo sapiens)
• Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia (2017, NA)
• Novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia (2017, NA)
• Glucose-lipid crosstalk in diabetic kidney disease (2017, Homo sapiens)
• In HF, SERCA2a is a vital target regulated by Lut for effective cardiomyocyte contraction and relaxation (2017, NA)
• Lut alleviates I/R injury by inhibiting apoptosis by up-regulating AKT, increasing BCL-2 protein and decreasing BAX protein (2017, NA)
• DNA interstrand crosslink (ICL) repair: Crosstalk between the Fanconi Anemia (FA) pathway, translesion synthesis (TLS) and homologous recombination (HR) (2017, NA)
• Elevated expression of Par3 promotes PCa metastasis via Hippo pathway inactivation (2017, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana,clinical samples)
• Osmolyte metabolic pathways reconstructed based on the de novo assembly and annotation of D (2017, NA)
• Reported enzyme targets of 3-bromopyruvate (shown in red boxes) (2017, NA)
• The molecular mechanism of AA action upon cardiac hypertrophy-associated fibrosis (2017, Rattus norvegicus,Terminalia arjuna,Homo sapiens)
• Schematic diagram of an IL-33 signaling pathway (2017, NA)
• Predicted target genes of miRNA-34a in renal cell carcinoma pathway [KEGG hsa05211] (2017, NA)
• Bladder cancer stem cells: clonal origin and therapeutic perspectives (2017, Homo sapiens,Mus musculus,Helicobacter pylori,Paraechinus aethiopicus)
• Bladder cancer stem cells: clonal origin and therapeutic perspectives (2017, Homo sapiens,Mus musculus,Helicobacter pylori,Paraechinus aethiopicus)
• A20 functions as mediator in TNFAlpha-induced injury of human umbilical vein endothelial cells through TAK1-dependent MAPK/eNOS pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL (2017, NA)
• Beta-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP)ribosylation (2017, Escherichia coli,Escherichia coli DH5alpha,Escherichia coli DH1,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Anaplastic lymphoma kinase (ALK) signaling: Pathway figure that depicts normal activation of ALK through ligand binding (2017, NA)
• Context-dependent transforming growth factor B (TGFB) signaling outputs arise from pathway interactions (2017, NA)
• Dopaminergic pathway genes and serotonergic pathway genes (2017, Homo sapiens,Mus musculus,Glossodia major)
• Multiple modes of AOAA’s action in cancer cells (2017, NA)
• Proposed model of the cell autophagy induced by SAHA and TRAIL DR5-CTSB in breast cancer cell lines (2017, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Triticum aestivum,Hepatitis B virus)
• Intracellular and Extracellular mode of Toll‐like receptor (TLR) signalling pathways: signalling heterogeneity in TLR pathways arises from the differential recognition of pathogen‐associated molecular patterns (PAMPs) by different TLRs (2017, NA)
• Lipid catabolism (2017, NA)
• Synaptic model proposed for extinction of memory (2017, Rattus norvegicus,Homo sapiens)
• Age‐associated defects interfering with function and survival of activated T cells (2017, NA)
• Dysregulated Toll‐like receptor signalling associated with advanced age (2017, NA)
• Different signalling pathway targets already used for interventions to reverse immunosenescence (2017, Homo sapiens)
• Schematic representation of the proposed IR signal diversification by ligand-induced crosstalk with molecular partners (2017, NA)
• Gene networks with the genes in core from GSEA analysis (2017, Mycobacterium tuberculosis,Listeria monocytogenes,Trypanosoma cruzi,Leishmania major,Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides)
• Design and validation of a 90K SNP genotyping assay for the water buffalo (Bubalus bubalis) (2017, NA)
• Regulatory roles of differentially expressed genes involved in the MAPK signaling pathway (a, map04010) and pathways in cancer (b, map05200) (2017, NA)
• Complement system (2017, NA)
• Signal transduction by flagellin in mammalian cells (2017, NA)
• Molecular mechanism of GIP- and GLP-1-induced insulin secretion and Beta-cell survival (2017, NA)
• Interaction diagram of miR-7-5p, TFF3 and the PI3K/Akt signalling pathway when miR-7-5p regulates the proliferation and migration of LS174T cells (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Kyoto Encyclopedia of Genes and Genomes and TGFB signaling pathway with changes between adult facial fibroblasts and neonate fibroblasts denoted by color code (2017, NA)
• N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Homo sapiens,Bos taurus,Macaca mulatta,Mustela putorius furo,Strongylocentrotus purpuratus,Lytechinus variegatus,Human immunodeficiency virus 1,Xenopus laevis,Cannabis sativa)
• Central metabolic pathway of Rlv3841 showing the metabolism of glucose and succinate (2017, Rhizobium leguminosarum,Rhizobium leguminosarum bv. viciae)
• Trx1/p21Ras-ERK1/2 MAP kinases/PEA-15/Txnip compartmentalized signaling pathway is stimulated by nitrosative/oxidative stress and is associated with tumor development (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Oryctolagus cuniculus)
• Proximal tubule (PT) phosphate reabsorption (2017, NA)
• Proximal tubule (PT) calcium (Ca 2+) reabsorption (2017, NA)
• Tissue injury adaptation and a precursor to the dysplasia–cancer sequence (2017, Mus musculus,Rattus norvegicus,Helicobacter pylori,Plasmid pTF1,Homo sapiens,Sus scrofa,Human papillomavirus,NA)
• Epigenetic mechanisms currently associated with aortic VICs (2017, Homo sapiens)
• CL deficiency causes an increase in mitochondrial ROS (2017, NA)
• CL in mitochondrial protein translocation and morphology (2017, NA)
• Signalling disruptions in Depdc5 FS/FS mice (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Danio rerio)
• TGFB/Smad classic pathway (2017, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Lareunionomyces loeiensis)
• Proposed mechanisms of miR-146a in alleviating experimental autoimmune anterior uveitis (EAAU) (2017, NA)
• MicroRNA sequence analysis identifies microRNAs associated with peri-implantitis in dogs (2017, NA)
• Chemokine signaling pathway significantly enriched in differentially expressed genes (2017, NA)
• Genes identified from the enrichment analysis were significantly associated with OSA comorbidities (2017, NA)
• Representative modules of ESCC-related metabolic network (2017, Homo sapiens)
• Suggested model for modulation of Wnt pathway by OCC-1 splice variants (2017, NA)
• MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response (2017, Homo sapiens,NA)
• MAPK pathways in ROS signaling and responses (2017, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Solanum tuberosum,Brassica napus,Nicotiana benthamiana,Pisum sativum,Botrytis cinerea,Medicago sativa,Catharanthus roseus,Vicia faba,Phytophthora infestans,Saccharomyces cerevisiae CAT-1,Nicotiana attenuata,Papaver rhoeas,Phytophthora cryptogea,Pseudomonas syringae,Xanthomonas campestris,Pseudomonas syringae pv. tomato str. DC3000,Streptococcus thermophilus,Pseudomonas cichorii,Homo sapiens)
• Putative mechanisms for activation and regulation of MAPK cascade by ROS (2017, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Solanum tuberosum,Brassica napus,Nicotiana benthamiana,Pisum sativum,Botrytis cinerea,Medicago sativa,Catharanthus roseus,Vicia faba,Phytophthora infestans,Saccharomyces cerevisiae CAT-1,Nicotiana attenuata,Papaver rhoeas,Phytophthora cryptogea,Pseudomonas syringae,Xanthomonas campestris,Pseudomonas syringae pv. tomato str. DC3000,Streptococcus thermophilus,Pseudomonas cichorii,Homo sapiens)
• RBP-J functions as a key negative regulator of osteoclastogenesis and inflammatory bone resorption (2017, NA)
• Leukocyte extravasation signaling pathway altered by a high-fat-diet, Taeumjowitang, and green tea in the epididymal white adipose tissue (2017, NA)
• Schematic illustration of the alterations of dendritic cells (DCs) in sepsis (2017, Homo sapiens,Mus musculus,Escherichia coli,Candida dubliniensis,Influenza A virus,Clonorchis sinensis)
• Non-apoptotic signaling pathway induced by CD95 (2017, NA)
• Self‐sustaining cancer cells in 3D (2017, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana,Moolgarda engeli)
• Schematic picture showing the neuroprotective effects of LBP through inhibiting the NR2B signaling pathway and activating the NR2A signaling pathway against ischemic/hypoxia injury (2017, NA)
• Result of the exploration of HTR1A functions involved in biological process pathways using the STRING database (http://string-db.org/newstring) (2017, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Sus scrofa,Cricetulus griseus,Homo sapiens,Human gammaherpesvirus 4,Zingiber officinale)
• ERBB signaling in CTCs of ovarian cancer and glioblastoma (2017, NA)
• Genetic alterations that lead to HIF activation in GBM (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,clinical samples)
• Scorpion and spider venoms in cancer treatment: state of the art, challenges, and perspectives (2017, NA)
• Interactions among the MAPK, NFKB, and Nrf2 signaling pathways contribute to the progression of HFC diet-induced NASH in the context of hypertension (2017, NA)
• Schematic diagram showing protective signaling of EPF in livers of HFD-fed mice (2017, NA)
• Hexokinases link DJ-1 to the PINK1/parkin pathway (2017, NA)
• Network based on a restricted number of genes after selection of topological parameters (2017, NA)
• Activation of the transforming growth factorB (TGFB) signaling pathway leading to a smooth muscle cell contractile phenotype (2017, Homo sapiens,Mus musculus)
• Upregulated genes involved in apoptosis signaling at 1 day after a single dose of 2 Gy Fe ions (2017, Saccharomyces cerevisiae,Armoracia rusticana,Campanula medium,Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Gorilla gorilla,Dipturus trachyderma)
• Upregulated genes involved in cell cycle regulated processes at 7 days after a single dose of 2 Gy X-rays (2017, Saccharomyces cerevisiae,Armoracia rusticana,Campanula medium,Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Gorilla gorilla,Dipturus trachyderma)
• Differentially expressed genes upon congenital neonatal human cytomegalovirus (HCMV) infection form distinct subnetworks (2017, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Ebola virus,Japanese encephalitis virus,Homo sapiens,Mus musculus,Bos taurus,Candida dubliniensis,NA,NA)
• BACE1-dependent NRG1/ErbB4 signaling pathway involving in the pathogenies of schizophrenia (2017, NA)
• AhRR with the canonical and non-canonical AhR pathways (2017, NA)
• The glycolytic pathway in E (2017, NA)
• Ingenuity pathway analysis of genes differentially expressed during the transition from differentiation day 0 to day 1 common to emerin-null cells and wildtype cells (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,Venustaconcha ellipsiformis,Moloney murine leukemia virus)
• Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment (2017, NA)
• The Regulatory Roles of Mitogen-Activated Protein Kinase (MAPK) Pathways in Health and Diabetes: Lessons Learned from the Pancreatic Beta-Cell (2017, Coxsackievirus B3,Enterovirus A71,Coxsackievirus,Mus musculus,Rattus norvegicus,Homo sapiens)
• TLR-signaling pathways (2017, NA)
• TRIMs in cytokine signaling (2017, NA)
• Model illustrating a proposed mechanism by which p38 MAPK signaling influences the response of cells to mechanical stress (2017, NA)
• Long non-coding RNAs associated with non-small cell lung cancer (2017, NA)
• Roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis (2017, NA)
• PRAS40 signaling in tumor (2017, Moloney murine leukemia virus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Volvox carteri,NA)
• Cross-talk between p21-activated kinase 4 and ERA signaling triggers endometrial cancer cell proliferation (2017, NA)
• ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway (2017, NA)
• ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway (2017, NA)
• Ingenuity pathway analysis of differentially expressed genes unique to emerin-null cells during transition from day 1 to day 2 of differentiation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,Venustaconcha ellipsiformis,Moloney murine leukemia virus)
• Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,Venustaconcha ellipsiformis,Moloney murine leukemia virus)
• Molecular basis of VDRA beneficiary action through the nephrin signalling pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanisms of hCG action on leiomyomal cells (2017, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• hCG signaling and effects on leiomyomal cells (2017, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• HSP40 family member, DNAJB6a (MRJ), prevents tumor formation through inhibition of the Wnt pathway (2017, NA)
• HSP27 mediated suppression of apoptosis promotes tumorigenesis (2017, NA)
• Proposed modification strategies of flavonoids, carotenoids and chlorophyll metabolic pathways in tepals of Chinese narcissus to acquire functional color pigments (2017, Narcissus tazetta subsp. chinensis)
• Glycans and insulin/IGF system in cancer: an integrated mechanism (2017, NA)
• Insulin/insulin-like growth factor (IGF) system (2017, NA)
• Interplay between melatonin signaling, cell contact-cell polarity complexes, mechanotransduction, and YAP/TAZ (2017, NA)
• Interplay between melatonin, YAP/TAZ, and metabolic pathways (2017, NA)
• Interplay between G-Protein Coupled Receptors (GPCR) signaling regulated by melatonin and GPCR signaling regulating YAP/TAZ (2017, NA)
• Oncosuppressive mechanisms mediated by melatonin (2017, NA)
• CdtB induced double strand breaks and activation of the ataxia-teleangiectasia mutated (ATM) signalling network (2017, NA)
• PALB2 in the DNA damage repair (2017, NA)
• Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 (2017, Homo sapiens)
• Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53 (2017, Homo sapiens)
• Molecular mechanism of Phases 1 and 2 SHM, involving MMR and BER proteins (2017, NA)
• Signaling events downstream of IL7R (depicted in purple) and the pre-BCR (depicted in black and red) involved in the regulation of RAG1/2 expression and Ig light chain recombination (2017, NA)
• Unlocking the NFKB Conundrum: Embracing Complexity to Achieve Specificity (2017, Homo sapiens)
• Various mechanisms by which alcohol may affect carcinogenesis (2017, NA)
• Pathways of ethanol metabolism (2017, NA)
• Greatwall–Endosulfine–PP2A-B55 pathway connects TORC1 with the activity of the SBF repressor Whi5 (2017, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Greatwall–Endosulfine–PP2A-B55 pathway connects TORC1 with the stability of the Cdk1 inhibitor Sic1 in budding yeast (2017, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Therapeutic targeting of the ribotoxic stress response (RSR) during Shiga toxicity (2017, NA)
• Neurotransmitter targets for therapeutic development in psychiatric disorders (2017, NA)
• TLR4 signaling mechanisms (2017, NA)
• Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,Venustaconcha ellipsiformis,Moloney murine leukemia virus)
• Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,Venustaconcha ellipsiformis,Moloney murine leukemia virus)
• Molecular basis of targeting PFKFB3 as a therapeutic strategy against cancer (2017, Homo sapiens,Mus musculus)
• Overexpression of stathmin plays a pivotal role in the metastasis of esophageal squamous cell carcinoma (2017, NA)
• Autophagy-related gene expression is an independent prognostic indicator of glioma (2017, NA)
• Mechanism of emodin to inhibit IAV replication and IAV viral pneumonia (2017, Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,Coxsackievirus,H3N2 subtype,Human orthopneumovirus,H7N9 subtype,H7N7 subtype,Armoracia rusticana,Matthiola incana,Polygonum cuspidatum,Rheum rhabarbarum,Rheum palmatum,Fallopia multiflora,Areca catechu,Rheum tanguticum,Raoulia australis,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells (2017, NA)
• The AChE–ACh active complex transduction pathway of the NO efflux from human erythrocytes supported by in vitro studies, as explained in the text [,,,,] (2017, Homo sapiens,Mus musculus,Bungarus sindanus)
• Working model for sensing of glucose availability by AMPK and its potential interactions with the mTORC1 signalling pathway at the lysosome (2017, NA)
• RSV inhibiting NKTCL cells (2017, Oryctolagus cuniculus,Capra hircus,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,NA)
• Predicted TGFB signaling pathway underlying hereditary hemorrhagic telangiectasia (HHT) (2017, NA)
• Novel aspects of tumor biology and translational approaches using zebrafish models (2017, NA)
• Metabolic rewiring in melanoma (2017, Homo sapiens,Mus musculus,NA)
• Metabolic rewiring in melanoma (2017, Homo sapiens,Mus musculus,NA)
• Metabolic rewiring in melanoma (2017, Homo sapiens,Mus musculus,NA)
• Crosslinks between integrin and wnt signalling (2017, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Psidium guajava)
• Differentially expressed genes between young and aged tibiae are significantly enriched for ECM-receptor interactions, TCA cycle and cell cycle pathway components (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Equus asinus)
• Rickettsia species synthesize fatty acids and glycerophospholipids from host precursors (2017, NA)
• Rickettsia species synthesize cell envelope glycoconjugates from imported host sugars and fuel the TCA cycle with a range of host-acquired metabolites (2017, NA)
• Activation and mechanism of action of Nrf2 (2017, Saccharomyces cerevisiae,Candida dubliniensis,Curcuma longa,Allium sativum,Pelargonium x hortorum,Phyllanthus niruri,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulations of Nrf2 by several factors (2017, Saccharomyces cerevisiae,Candida dubliniensis,Curcuma longa,Allium sativum,Pelargonium x hortorum,Phyllanthus niruri,Mus musculus,Rattus norvegicus,Homo sapiens)
• Examples of genes (in red) within the HIF pathway in which positive selection has been identified in high-altitude populations (2017, NA)
• Cross-talk between the signal transduction pathways involved in mechanical stimulation and diacerein treatment of chondrocytes (2017, NA)
• Schematic diagrams of the pathway models involved in the early and late phases of ERK and AKT activation by orbital shaking (2017, NA)
• SASP regulation (2017, Drosophila melanogaster,Caenorhabditis elegans,Pleocyemata sp.,Homo sapiens,Mus musculus,gut metagenome,Fusobacterium nucleatum,Calloplesiops altivelis,Elephas maximus,NA)
• Hypothetic pathogenesis of OPLL (2017, NA)
• Regulation and signaling crosstalk of the Hippo pathway (2017, Homo sapiens)
• LPS-induced abortion by regulating strong cellular network (2017, NA)
• Galactose metabolism pathway (2017, NA)
• Proposed signaling pathway for prostacyclin (PGI2) receptor-mediated ATP release from erythrocytes (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Plasmodium berghei)
• Frequent genetic alterations of PI3K/mTOR signaling pathway in HNSCC (2017, NA)
• Complement-mediated haemolysis in chronic cold agglutinin disease and cold agglutinin syndrome (2017, NA)
• Proposed mechanisms of cell injury induced by APOL1 variants (2017, NA)
• Typical structure and content of exosomes (2017, NA)
• Apoptosis and p53 signaling related to Cr(VI) exposure (2017, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens)
• Effect of PCB126 exposure on the calcium signaling pathway (2017, Danio rerio,Homo sapiens)
• Signalling pathway of cytokine-cytokine receptor interaction signalling pathway (2017, Homo sapiens,Venustaconcha ellipsiformis)
• Molecular events occurring in Alzheimer’s Disease (AD) following locus coeruleus (LC) norepinephrine (NE) loss and autophagy impairment (2017, Mus musculus,Rattus norvegicus,Armoracia rusticana,Gastrodia elata,Homo sapiens,prion)
• Crosstalk between IGF-1R and other RTKs/steroid hormone receptors (2017, NA)
• IGF-1R downstream signaling (2017, NA)
• Components of the insulin/IGF axis (2017, NA)
• Metabolic pathways (2017, NA)
• Significantly differentiated expressed genes that were identified by KEGG as involved in the “Phototransduction – fly” signaling pathway in NBSE vs (2017, Macrobrachium nipponense)
• Multiple miRNA biogenesis pathways (2017, NA)
• PVAT‐derived vasoactive molecules (2017, NA)
• Part of the PPAR signal pathway (2017, NA)
• T-helper responses to A (2017, Aspergillus fumigatus,Homo sapiens)
• Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death (2017, herbal medicine,Olea europaea,Vasconcellea candicans,Citrus macrophylla,Physalis angulata,Tabernaemontana elegans,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway (2017, Aplysia sp.,Aplysia kurodai,Homo sapiens,Rattus norvegicus,Bos taurus,Glycine max)
• Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma (2017, NA)
• Integrated analysis profiles of long non-coding RNAs reveal potential biomarkers of drug resistance in lung cancer (2017, Homo sapiens)
• Cross-talk between adipocytes, macrophages, and cancer cells modulating the tumor microenvironment (2017, Mus musculus,Rattus norvegicus,Curcuma longa,Rheum palmatum,Homo sapiens,Listeria monocytogenes)
• Hypoxia inducible factor-1A (HIF-1A) is a major transcriptional regulator whose levels increase in hypoxia, leading to flipping the “angiogenic switch” on (2017, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• The Shh, TGFB/BMP, and Wnt morphogenic signaling pathways (2017, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• NF-kB pathway (2017, NA)
• Rep-MYB-mediated repression of G2/M-specific genes under DNA stress conditions (2017, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Escherichia coli,Escherichia coli BL21,Homo sapiens,Drosophila melanogaster,Dipturus trachyderma)
• Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells (2017, Porphyromonas gingivalis,Homo sapiens)
• Mechanisms of action for LINGO-1 and speculative AMIGO3 signaling in oligodendroglia.(A) LINGO-1 is able to bind to ErbB2 and prevent its translocation to the lipid rafts on oligodendroglial membranes (2017, Mus musculus,Rattus norvegicus,Danio rerio,Meleagris gallopavo,Homo sapiens)
• AMIGO3 and LINGO-1 signaling in neurons.Both AMIGO3 and LINGO-1 are able to form a complex with NgR1 and P75/TROY (Mi et al., 2004; Ahmed et al., 2013) (2017, Mus musculus,Rattus norvegicus,Danio rerio,Meleagris gallopavo,Homo sapiens)
• Multiple kinases-phosphatases mediated progressive Smo phosphorylations interpret morphogenic Hh signals in signal-receiving cells (2017, NA)
• Cytokine-cytokine receptor interaction (2017, Gallus gallus,Homo sapiens)
• FA/TAG metabolism in hepatocytes (2017, NA)
• Relation between mammalian MAPK cascades and other kinases capable to induce cell responses involved in cancer (2017, NA)
• ATX-LPA axis promotes cancer-related inflammation (2017, NA)
• HMGB1 receptor and possible signaling pathways (2017, NA)
• NEMO Peptide Inhibits the Growth of Pancreatic Ductal Adenocarcinoma by Blocking NFKB Activation (2017, Bos taurus,Canis lupus familiaris,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• Crosstalk between the genes (in blue) obtained from the systematic review of LR and their biological functions in the dopaminergic neurons (2017, NA)
• Signaling pathways of IL-2 (2017, NA)
• Connection among hub genes predicted on KEGG pathways (2017, Homo sapiens,Gorilla gorilla,Bos taurus,Gallus gallus,clinical samples)
• GPR and HDAC co-regulation network related to epithelium metabolism (2017, NA)
• GPR and HDAC co-regulation network related to epithelium growth (2017, NA)
• Antiviral apoptotic pathways (2017, Vaccinia virus,Enterovirus C,Coxsackievirus B3,Enterovirus A71,Encephalomyocarditis virus,Coxsackievirus,Foot-and-mouth disease virus,Human rhinovirus sp.,Hepatovirus A,Theilers encephalomyelitis virus,enterovirus D68,Echovirus,rhinovirus A2,Human enterovirus,Human rhinovirus 1A,rhinovirus B14,Homo sapiens,Mus musculus,NA)
• Molecular and cellular mechanisms involved in magnesium-enhanced bone formation and bone fracture healing (2017, NA)
• Extracellular matrix-receptor interaction signaling pathway (2017, Homo sapiens)
• Regulation of intrinsic cancer metabolism by obesity-associated growth factors (2017, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Ovis aries,Mouse mammary tumor virus)
• Schematic overview of MYC-mediated metabolic pathways (2017, Homo sapiens)
• Schematic diagram summarizing factors influencing the signaling efficacy of the TLR2/1-VDR pathway in response to TLR2/1 elicitation (2017, Candida albicans,Candida albicans 24A,Homo sapiens,Mus musculus,Capra hircus,Human immunodeficiency virus 1,Dipturus trachyderma,Mycobacterium tuberculosis SP1)
• Graphic representation of pathways for furanodiene-induced cell apoptosis and for doxorubicin-resistant MCF-7 cells outcomes (2017, NA)
• Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12–CXCR4 associated biological regulatory network (2017, NA)
• Meta-analysis of biomarkers for severe dengue infections (2017, NA)
• The PI3K-Akt signaling pathway in the developmental competence of bovine oocytes (2017, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: clinical impact of alectinib (2017, NA)
• The proposed therapeutic strategy to improve the efficacy of PKM targeting therapy in cancer cells in the background of the cellular status of the LKB1-AMPK pathway (2017, NA)
• The calcineurin–NFAT signaling pathway and the potential role of CEFIP (2017, NA)
• Biosynthetic pathway of NAD+ production starting from Na (2017, NA)
• Physiological functions of ataxin-2 (2017, NA)
• Molecular mechanisms of chemoresistance in cancers (2017, Homo sapiens,Mus musculus,Dipturus trachyderma)
• SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells (2017, NA)
• Mechanisms of Ang II-induced AT1R-dependent regulation on BK channels (2017, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Mechanisms used by Toxoplasma gondii, type I strain, to modulate mainly immune system at its favor (2017, NA)
• Natural killer (NK) cell activating receptor signaling (2017, NA)
• Hypothetical mechanism of the inhibitory effect of TNF‐A in monocyte cultures (2017, Homo sapiens,Mus musculus)
• SOCS molecules: the growing players in macrophage polarization and function (2017, Schistosoma mansoni,Schistosoma japonicum,Penaeus vannamei,Mus musculus,Rattus norvegicus,Vaccinia virus,Murid betaherpesvirus 1,Homo sapiens,Oryctolagus cuniculus,Lacticaseibacillus paracasei)
• SOCS molecules: the growing players in macrophage polarization and function (2017, Schistosoma mansoni,Schistosoma japonicum,Penaeus vannamei,Mus musculus,Rattus norvegicus,Vaccinia virus,Murid betaherpesvirus 1,Homo sapiens,Oryctolagus cuniculus,Lacticaseibacillus paracasei)
• Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy (2017, Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy (2017, Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• Hedgehog-GLI pathway in embryonic development and cancer: implications for pulmonary oncology therapy (2017, Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy (2017, NA)
• Wnt/Beta-catenin pathway in arrhythmogenic cardiomyopathy (2017, NA)
• Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions (2017, Homo sapiens,Mus musculus,NA)
• Simplified schematic of different metabolites and processes in the brain that can be interrogated using 1H MRS, 31P MRS, 13C MRS, and DNP 13C MRS (2017, NA)
• Proposed mechanism for the proliferation inhibitory effects of ART in HCT116 cells (2017, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae)
• JAK inhibition as a therapeutic strategy for immune and inflammatory diseases (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,JC polyomavirus)
• RA and omega-3 PUFA co-treatment activates autophagy in cancer cells (2017, NA)
• Integrated analysis of chromosome copy number variation and gene expression in cervical carcinoma (2017, NA)
• Proteasome and ErbB signaling pathway (2017, Escherichia coli,Vibrio cholerae,Escherichia coli IS9,Vibrio cholerae MS6,Schizosaccharomyces pombe,Agriosomyces longus,Homo sapiens,Caenorhabditis elegans,prion)
• Proposed model by which mesenchymal stromal cell (MSC) derived soluble PD‐1 ligands modulate the activation status and effector function of CD4+ T cells (2017, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Simian immunodeficiency virus,Lactococcus phage P001)
• Endocannabinoid‐mediated long‐term depression of inhibitory transmission (iLTD) in GABAergic pre‐synaptic terminal induced by endogenous brain‐derived neurotrophic factor (BDNF)‐TrkB signaling during the critical period (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Felis catus)
• The shared and specific mechanism of four autoimmune diseases (2017, Escherichia coli,Vibrio cholerae,Escherichia coli IS9,Vibrio cholerae MS6,Schizosaccharomyces pombe,Agriosomyces longus,Homo sapiens,Caenorhabditis elegans,prion)
• The SMC1 participating in DNA damage repair signaling pathway (2017, NA)
• Modulating NAD + metabolism, from bench to bedside (2017, NA)
• Chlamydial iron acquisition (2017, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Shigella flexneri,Streptomyces coelicolor,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia trachomatis,Neisseria meningitidis,Mycobacterium avium,Neisseria gonorrhoeae,Brucella abortus,Yersinia pestis,Chlamydia pneumoniae,Bradyrhizobium japonicum,Coxiella burnetii,Chlamydia muridarum,Ehrlichia chaffeensis,Corynebacterium diphtheriae,Chlamydia psittaci,Treponema pallidum,Brucella abortus 2308,Yersinia pestis 24H,Rickettsia rickettsii,Ehrlichia canis,Chlamydia caviae,Chlamydia pecorum,Neorickettsia sennetsu,Chlamydia suis,Plasmid ColV-K30,Chlamydia suis MD56,Chlamydia muridarum str. Weiss,Bos taurus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Danio rerio,Lepidocybium flavobrunneum,Homo sapiens,Drosophila melanogaster,Anethum graveolens)
• Shared and specific mechanism of four autoimmune diseases (2017, Escherichia coli,Vibrio cholerae,Escherichia coli IS9,Vibrio cholerae MS6,Schizosaccharomyces pombe,Agriosomyces longus,Homo sapiens,Caenorhabditis elegans,prion)
• Differentially-expressed gene pathway network generated using CluePedia (2017, NA)
• DET- and IDET-induced apoptosis in different cancer cell lines (2017, NA)
• Signaling pathways corresponding to Tables  and (2017, NA)
• Activation of NFKB and IL6/STAT3 signalling pathways in NPC cells by multiple EBV-encoded latent gene products (2017, NA)
• Interactions between DNA tumour viruses and the DNA damage response (2017, NA)
• Schematic diagram illustrating the molecular mechanisms for ATP release and hydrolysis, and ATP-induced Ca2+signalling in MSC (2017, NA)
• Model Signaling Network (2017, NA)
• Model Signaling Network (2017, NA)
• Computational modeling framework (2017, NA)
• Transcriptional regulation of glycolytic and mitochondrial metabolism (2017, Homo sapiens,Mus musculus)
• Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages (2017, NA)
• TGFB signaling pathway (2017, NA)
• Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance (2017, Xenopus laevis,Emmelichthys struhsakeri,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Molecular changes driving the Warburg effect (2017, Xenopus laevis,Emmelichthys struhsakeri,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Glucose metabolism in cells (2017, Xenopus laevis,Emmelichthys struhsakeri,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Involvement of galectins during carcinogenesis (2017, Homo sapiens,Mus musculus,Nicotiana tabacum,Human papillomavirus)
• Lysophospholipid-mediated PPARG signaling (2017, NA)
• Role of IFNB in host–pathogen interaction in Mtb infection (2017, Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Mycolicibacterium smegmatis,Francisella tularensis,Mycobacterium avium,Legionella pneumophila,Mycobacterium leprae,Moraxella bovis,Mycobacterium avium subsp. avium,Human immunodeficiency virus 1,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,NA)
• InterferonB (IFNB) signaling pathways and autocrine/paracrine loop (2017, Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Mycolicibacterium smegmatis,Francisella tularensis,Mycobacterium avium,Legionella pneumophila,Mycobacterium leprae,Moraxella bovis,Mycobacterium avium subsp. avium,Human immunodeficiency virus 1,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,NA)
• Hypertonicity boosts cytotoxicity of SMAC mimetics (2017, NA)
• Schematic view of (A) the NFKB signaling pathway and (B) the JAK-STAT signaling pathway that contribute to the pathogenesis of psoriasis and its novel targeting molecules (2017, NA)
• Two strategies for photoactivation of cell signaling pathways (2017, NA)
• Selected microRNA-target (cell cycle pathways) interaction data (2017, Glycine max,Curcuma longa,Homo sapiens,Mus musculus,Calloplesiops altivelis)
• Caspases regulate RLR and TLR antiviral signaling (2017, NA)
• Caspases control the cGAS-STING signaling pathway (2017, NA)
• Caspases in extrinsic and intrinsic apoptosis (2017, NA)
• Different hypotheses for depression converge together and are interconnected (2017, NA)
• Results of PPI network analyis (2017, NA)
• Autocrine ATP signaling pathway controls astrocyte glutamate release and neuronal activity (2017, NA)
• Melanoma (Skin) tumorigenesis pathway, collected from KEGG (2017, NA)
• Regulation and interaction network model of 17 cytokines (2017, NA)
• Interrelationships between programmed cell death (2017, Mus musculus,Cricetus cricetus,Arachis hypogaea,Melaleuca alternifolia,Homo sapiens,Danio rerio,Listeria monocytogenes)
• Signaling pathways involved in GBM-induced apoptosis (2017, Mus musculus,Cricetus cricetus,Arachis hypogaea,Melaleuca alternifolia,Homo sapiens,Danio rerio,Listeria monocytogenes)
• HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection (2017, NA)
• Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage (2017, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Bacillus velezensis At1,Homo sapiens,Mus musculus,Human gammaherpesvirus 8,NA)
• Remodeling the blood–brain barrier microenvironment by natural products for brain tumor therapy (2017, NA)
• Regulation of miRNA expression in response to maternal disease and stress (2017, NA)
• An overview of roles of miRNAs as a regulator of DDR in response to radiation in cancers (2017, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio)
• Influence of PM10 exposure on coagulation (2017, Homo sapiens,Mus musculus,Bos taurus)
• Signaling pathways that are activated by TMEM16A in cancer (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Polyura schreiber)
• The PI3K/Akt pathway: a critical player in intervertebral disc degeneration (2017, NA)
• PI3K/Akt pathway: a critical player in intervertebral disc degeneration (2017, NA)
• Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials (2017, NA)
• Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials (2017, NA)
• Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials (2017, NA)
• Autophagy in hepatocellular carcinoma: friend or foe (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Gallus gallus)
• Promising landscape for regulating macrophage polarization: epigenetic viewpoint (2017, NA)
• IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NFKB pathway and reduction of JNK in HNSCC (2017, NA)
• Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha (2017, NA)
• Equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila (2017, Homo sapiens,Oryctolagus cuniculus,Capra hircus,Macaca mulatta,Papio anubis,Cervus elaphus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus)
• The signaling pathway (2017, Homo sapiens,clinical samples)
• Auxin biosynthetic pathways in Arabidopsis thaliana (2017, Arabidopsis thaliana)
• Induction of PD-L1 by IFNG signaling pathway and microRNAs target the key genes in the pathway (2017, NA)
• Interactions between circadian disorders and the TGFB1 signaling and WNT/Beta-catenin pathway in the energetic metabolism of fibrosis (2017, NA)
• 5-LO pathway: biosynthesis, signaling, and effect on cardiovascular system (2017, NA)
• Mechanisms of electromagnetic field regulation on neural stem cells (2017, NA)
• Schematic drawing of the efferent signaling pathway of the inflammatory reflex in the context of the cholinergic system in immune cells (2017, NA)
• 5-HT2A receptor antagonist contributing to DM-induced cardiovascular complications (2017, NA)
• 5-HT biosynthesis and metabolism in peripheral tissues (2017, NA)
• A crosstalk between endoplasmic reticulum (ER) stress and p38 mitogen-activated protein kinase (p38 MAPK) pathway in the context of pemphigus (2017, Hepatitis B virus,Human gammaherpesvirus 4,Homo sapiens,Mus musculus)
• EGFR cell signaling and lncRNAs relationship in lung cancer therapy resistance (2017, NA)
• Changes in Adipose Tissue During Weight Gain (2017, Homo sapiens,Mus musculus)
• Molecular mechanism underlying cardiovascular diseases associated with the changing of intracellular Ca2+ through TRPCs (2017, NA)
• Canonical Wnt signaling pathway (2017, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Bos taurus,Mouse mammary tumor virus)
• Interactions between WNT/Beta-catenin pathway and aerobic glycolysis (2017, NA)
• Mechanism of action of Globotriaosylceramide (Gb3) and Globotriaosylsphingosine (Lyso-Gb3) in Fabry’s disease podocyte (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Danio rerio,Ovis aries)
• Activation of WNT signaling by CHIR is crucial for differentiation (2017, NA)
• P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells (2017, Homo sapiens)
• P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells (2017, Homo sapiens)
• P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells (2017, Homo sapiens)
• P38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells (2017, Homo sapiens)
• Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRA/AKT cascade restrains tuberous sclerosis complex-associated tumor development (2017, NA)
• Systematic analysis of coronary artery disease datasets revealed the potential biomarker and treatment target (2017, NA)
• Mapping the STK4/Hippo signaling network in prostate cancer cell (2017, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,NA)
• Prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• TCA cycle and glycolysis and gluconeogenesis metabolic pathway (2017, Escherichia coli,Helicobacter pylori,Escherichia coli O157H7,Roseburia hominis,Blautia obeum,Kineothrix alysoides,Faecalitalea cylindroides T2-87,Homo sapiens,Mus musculus,gut metagenome)
• Proteasome Inhibitors: Structure and Function (2017, Homo sapiens)
• Canonical and noncanonical inflammasomes (2017, NA)
• The Hedgehog signaling pathway (2017, NA)
• YAP is regulated by various factors during hepatocarcinogenesis in addition to the members of the Hippo signaling pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Hippo/YAP signaling pathway maintains the balance between cell proliferation and apoptosis (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Differential metaMIR analysis recovers miRNAs involved in cancer (2017, NA)
• IPA canonical pathway analysis and molecular activity of genes regulated by p53 in response to OT in differentiated SH-SY5Y cells (2017, Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Hydroquinone suppresses IFNB expression by targeting AKT/IRF3 pathway (2017, NA)
• Sodium butyrate has context-dependent actions on dipeptidyl peptidase-4 and other metabolic parameters (2017, NA)
• Diagram of muscle‐growth signaling pathway and differentially expressed genes, thus summarizing the effect of thermal gradient on muscle growth (2017, Gallus gallus,Danio rerio,Salmo salar,Dipnomorpha,Salmo trutta,Oreochromis niloticus,Dicentrarchus labrax,Gadus morhua,Fundulus heteroclitus,Melanogrammus aeglefinus,Solea senegalensis,Megalobrama amblycephala,Forsterygion lapillum,Engraulis japonicus,Lycium andersonii,Homo sapiens)
• mTOR signaling pathway and its upstream elements (2017, NA)
• Novel rapid-acting antidepressants: molecular and cellular signaling mechanisms (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Connectivity analysis of gene products differentially expressed by tissue type and menstrual phase (2017, NA)
• Signalling pathways in the TLR response (2017, Human immunodeficiency virus 1,H5N1 subtype,H7N9 subtype,Plasmodium falciparum,Plasmodium vivax,Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis)
• HDL cardioprotection (2017, NA)
• Cross-link between TGFB pathway, Wnt pathway, and ILK pathway (2017, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Lareunionomyces loeiensis)
• Mechanisms of steroid hormones action on the uNK cells (2017, Homo sapiens,Mus musculus,Mouse mammary tumor virus,clinical samples)
• Summary of nitrate signaling and assimilation (2017, NA)
• An “integrator” role for Smad3 in the maintenance of chronic myelogenous leukemia (CML) stemness (2017, NA)
• Proposed role of molecular and small molecule chaperones in proteostasis (2017, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Adeno-associated virus)
• Sphingosine-1-phosphate (S1P) in estrogen receptor- (ER-) positive breast cancer (2017, NA)
• Summary of changes in cell signaling pathways in mouse kidneys as a result of CypD ablation (2017, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Formoterol, but not clenbuterol, induces MB in a GBGamma-Akt-NOS-sGC-dependent manner despite increased cAMP accumulation (2017, NA)
• Pro- and antitumoral effects of tumor-immune cell heterotypic GJICs (2017, Escherichia coli,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Shigella flexneri,Chlamydia trachomatis,Citrobacter rodentium,Staphylococcus epidermidis,Human immunodeficiency virus,Adeno-associated virus,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Mus musculus,Rattus norvegicus,Homo sapiens)
• Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information (2017, NA)
• Regulation of autophagy signaling pathway (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Curcuma longa,Homo sapiens,Danio rerio,Streptomyces hygroscopicus)
• HIV-1 gp120 up-regulates BDNF expression in BV2 cells via Wnt/Beta-catenin signaling pathway (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Armoracia rusticana)
• Metabolic pathway involving genes present for egg count per gram of feces (EPG) and famacha (FAM) traits (2017, NA)
• Cell surface HSPGs consists of a protein core linking several linear heparan sulfate (HS) chains (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Hepatitis B virus)
• PD1 signal transduction pathways in T cells (2017, Homo sapiens,Mus musculus)
• Reduction–oxidation pathways involved in cancer development: a systematic review of literature reviews (2017, NA)
• Reduction–oxidation pathways involved in cancer development: a systematic review of literature reviews (2017, NA)
• Postendocytic sorting of receptors along the endolysosomal pathway (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Boa constrictor)
• Signaling pathways that can cross talk with TNT formation (2017, NA)
• Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis (2017, NA)
• CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Lareunionomyces loeiensis,Citrus aurantiifolia,Homo sapiens,Escherichia coli DH5alpha)
• From mice to men: TRPC3 in cerebellar ataxia (2017, Homo sapiens,Mus musculus)
• AC6 and AC6-ΔN signaling (2017, NA)
• Development of T cells from stem cells in mice and humans (2017, Homo sapiens,Mus musculus,Caenorhabditis elegans,NA)
• Adaptation to macrophage killing by Talaromyces marneffei (2017, Talaromyces marneffei,Homo sapiens)
• Establishment of minimal positive-control conditions to ensure brain safety during rapid development of emergency vaccines (2017, NA)
• Mechanism of axon degeneration and sites of action of chemotherapeutic drugs (2017, NA)
• Schematic description of EET-mediated perturbations in the Wnt1-NOV-PGC-1Alpha-HO-1 pathway in cardiac and adipose tissue of db/db mice (2017, NA)
• Action of commonly used systemic agents in treatment of renal cell carcinoma (RCC) (2017, NA)
• Proposed mechanisms underlying luminal FFA2 activation under normal conditions and cyclooxygenase (COX) inhibition in the duodenum (2017, NA)
• Proposed model depicting cross-talk between Gq-coupled GPCRs and CLEC-2 pathways (2017, Mus musculus,Homo sapiens)
• Mechanisms by which fusion genes promote kinase activation and cell survival and opportunities for therapeutic intervention (2017, NA)
• Insulin-like growth factor 1-signaling pathway in cells (2017, NA)
• Five enriched pathways and their contributing DEGs are shown (2017, NA)
• Multi-level complexity underlying the host-pathogen interaction in bacterial lung infection (2017, Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Pseudomonas fluorescens,Acinetobacter baumannii,Francisella tularensis,Bordetella pertussis,Bordetella bronchiseptica,Influenza A virus,unidentified influenza virus,H1N1 subtype,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Trichostrongylus retortaeformis)
• The auto-immune attack to the beta-cells in Type 1 diabetes mellitus (2017, NA)
• Nuclear factor-E2-related factor 2 (NRF2) pathway with a focus on skin barrier function and environmental stress protection (2017, Solanum lycopersicum,Curcuma longa,Salvia miltiorrhiza,Zingiber officinale,Cinnamomum verum,Platycodon grandiflorus,Bixa orellana,Mus musculus,Rattus norvegicus,Homo sapiens)
• P53 and pRB pathways during senescence (2017, Saccharomyces cerevisiae,Nicotiana tabacum,Candida albicans,Homo sapiens,Mus musculus)
• ASFV entry and uncoating (2017, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus type 16,Human betaherpesvirus 5,Vesicular stomatitis virus,Vaccinia virus,Semliki Forest virus,Human adenovirus sp.,African swine fever virus,Human adenovirus 2,Echovirus E1,Human adenovirus B3,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,NA)
• TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis (2017, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Salmonella enterica,Pseudomonas aeruginosa BL10,unidentified influenza virus,H1N1 subtype,Vaccinia virus,Subgroup A,Agaricus bisporus,Sparganium stoloniferum,Urtica thunbergiana subsp. dentata,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Vipera berus berus,NA)
• Notch signaling in gastric carcinoma: molecular pathogenesis and novel therapeutic targets (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Helicobacter pylori)
• Proposed model for the regulation of synaptic restructuring by Wnt during learning (from ) (2017, NA)
• Host DNA damage response pathways (2017, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Betapolyomavirus macacae,Human papillomavirus types,human papillomavirus 18,Alphapapillomavirus 7,human papillomavirus 31,Bovine papillomavirus,Homo sapiens,Mus musculus,NA,NA)
• Pro-apoptotic role of HBV (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Myxoma virus,Avian leukosis virus,Duck hepatitis B virus,Woodchuck hepatitis virus,Avian leukemia virus,hepatitis B virus genotype A,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• Inhibition of apoptosis by hepatitis B Virus (HBV) infection (2017, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Myxoma virus,Avian leukosis virus,Duck hepatitis B virus,Woodchuck hepatitis virus,Avian leukemia virus,hepatitis B virus genotype A,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• Extrinsic and intrinsic apoptotic pathways (2017, NA)
• PI3K/AKT and RAS/EGFR/ERK pathways (2017, NA)
• Changes in hepatic gene expression associated with the PPARA signalling pathway and fatty acid metabolism between broilers (n = 6) and layers (n = 6) (2017, NA)
• Signalling pathway in normal and hyperglycemia patients (2017, NA)
• Proposed mechanisms by which dietary polyphenols inhibit EMT and cancer metastasis (2017, NA)
• MYD88-mediated TLR4 signaling pathway results in the production of pro-inflammatory cytokines (2017, NA)
• The molecular mechanisms of nintedanib activity with regard to the SHP-1/p-STAT3 pathway (2017, NA)
• Comprehensive molecular biomarker identification in breast cancer brain metastases (2017, NA)
• MEK inhibitors suppress ERK‐mediated HER2 Thr701 phosphorylation to enhance clathrin‐dependent HER2/EGFR dimerization and subsequent Akt activation (2017, NA)
• A9nAChR involved signal pathway in breast cancer (2017, NA)
• Epigenetic regulation of peroxisome proliferator-activated receptorA (PPARA) in fatty acid oxidation (FAO) genes (A–C) and PPARA signaling to the FAO metabolome (D) (2017, NA)
• Merged network based on eight upstream regulators, of which E2f, ERBB2, IL6, HGF, and RABL6 were in a predicted activation state (z-score > 2) and let-7, TP53, and CDKN2A were in a predicted inhibition state (z-score < - 2) (2017, NA)
• Comprehensive molecular biomarker identification in breast cancer brain metastases (2017, NA)
• Top canonical pathway is entitled, role of BRCA1 in DNA damage response (2017, NA)
• Parapoxviral virion protein targets the retinoblastoma protein to inhibit NFKB signaling (2017, NA)
• The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts (2017, NA)
• Physiology of the VHL-HIF pathway along with proposed etiopathogenesis that leads to metastatic ccRCC (2017, NA)
• Ubiquitin signaling in both sub-pathways of nucleotide excision repair (NER), global genomic (GG-) and Transcription coupled NER (TC-NER), and double-strand break (DSB) repair (2017, Homo sapiens,Saccharomyces cerevisiae)
• Schematic diagram illustrating the mechanisms of how the estrogen receptor (ER) coordinates with the epidermal growth factor receptor (EGFR) to affect the cell growth in the lung adenocarcinoma (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Equus caballus)
• Differentially expressed genes associated with the cell cycle were annotated by KEGG (2017, Danio rerio,Dipturus trachyderma,Oncorhynchus mykiss,Cyprinus carpio,Salmo salar,Dipnomorpha,Salmo trutta,Paralichthys olivaceus,Dicentrarchus labrax,Gadus morhua,Sparus aurata,Larimichthys crocea,Pagrus pagrus,Siniperca chuatsi,Solea solea,Gymnocypris przewalskii,Candida dubliniensis,Ipomoea batatas,Homo sapiens,Mus musculus,Infectious spleen and kidney necrosis virus)
• Simplified metabolic scheme and signal transduction pathway for the role of sulfur in regulating Cd accumulation and tolerance (2017, NA)
• Notch signaling in cell-cell communication between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) (2017, NA)
• Notch signaling modulates endothelial cells’ (EC) fate associated with neointimal hyperplasia (2017, NA)
• Signaling pathways involved in MSC-mediated therapeutic strategies in the eye (2017, NA)
• Acetylcholine‐dependent upregulation of TASK‐1 channels in thalamic interneurons by a smooth muscle‐like signalling pathway (2017, NA)
• DSB repair by NHEJ and HR (2017, NA)
• FGFR3–TACC3 contributes to oncogenesis (2017, NA)
• Schematic overview of the 57 meta-signature genes, their literature-based localisation and involvement in the mid-secretory phase endometrium (2017, Homo sapiens,Bos taurus,Sus scrofa,Macaca mulatta,Mus musculus,unidentified)
• The JAK-STAT pathway (2017, Homo sapiens,Mus musculus,Myeloproliferative leukemia virus)
• Vascular endothelial growth factor-B in metabolic homoeostasis: current evidence (2017, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Schematic representing the key role of IFNA and LPS-activated monocyte-derived exosomes in brain endothelial stimulation (2017, NA)
• Signaling pathways altered by XWL-1-48 (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Hepatitis B virus,Malus domestica)
• Complement activation pathways and allograft immunity (2017, NA)
• Ca2+ and ROS crosstalk between ER and mitochondria, with emphasis on redox control of the MCU (2017, NA)
• The mechanism by which 20E regulates PKCD expression and EcRB1 phosphorylation (2017, NA)
• High activity of immune response (2017, Homo sapiens,Escherichia coli IS1)
• Study on molecular mechanism of ANOS1 promoting development of colorectal cancer (2017, NA)
• PI3K/PTEN/AKT pathway dysregulation in prostate tumor cells (2017, NA)
• Downregulation of the neurotrophin-MAPK signaling pathway in DPN (2017, NA)
• Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions (2017, NA)
• FLT3 kinase signaling pathway and sites blocked by FLT3 inhibitors (2017, NA)
• PFKFB3-driven glycolysis and the central role of FAO via CPT1a function in ECs (a) Schematic of PFKFB3 as a key regulator of the glycolytic activity in ECs and the angiogenic switch (2017, NA)
• Molecular pathways involved in the maintenance of the MDSC suppressive function.A wide variety of proinflammatory factors are involved in the induction of the suppressive function in MDSCs (2017, NA)
• MTORC1 pathway: effect on TLR signaling cascades and modulation by bacteria (2017, NA)
• Localization of the key Plasmodium cyclic nucleotide signalling components in a merozoite prior to egress (2017, Toxoplasma gondii,Plasmodium falciparum,Plasmodium berghei,Plasmodium yoelii,Plasmodium chabaudi,Plasmodium knowlesi,Eimeria tenella,Plasmodium gallinaceum,Plasmodium falciparum LE5,Gallus gallus,Xenopus laevis,Lareunionomyces loeiensis,Musa acuminata,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,NA)
• PARP inhibitors cause DNA DSB (double strand break) by via inhibition of PARP enzyme activity and PARP trapping (2017, NA)
• Significant association of the 97 gene signature with transcription factors TP53 and HIF1A (2017, NA)
• Presence of Androgen Receptor Variant in Neuronal Lipid Rafts (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Most significantly relevant pathways and highly linked molecules (identified molecules from 17 preclinical studies which to explore the potential mechanisms of TLs for pancreatic cancer) relevant to the merged bionetwork (2017, NA)
• NADPH oxidase inhibition by bacterial pathogens in PMNs (2017, NA)
• Signaling pathway changes triggered by HLJDD and its three principals (2017, Solanum lycopersicum,Melia azedarach,Ipomoea purpurea,Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus)
• BMP signalling utilises canonical Smad dependant pathways and non-canonical Smad-independent pathways (2017, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Diaporthe sclerotioides,clinical samples)
• The role of the Dishevelled DEP domain in Wnt/Beta-catenin signal transduction (2017, NA)
• Major mTOR signaling network (2017, NA)
• Simplified mTOR signaling network with interactions inferred from modeling approaches (2017, NA)
• Role of Pontin/Reptin in the EMT pathway (2017, NA)
• Regulation of DNA damage response and repair by Pontin/Reptin (2017, NA)
• Regulation of transcription factors by Pontin/Reptin (2017, NA)
• Regulation of the G1/S cell cycle checkpoint pathway by Pontin/Reptin at multiple levels (2017, NA)
• New perspectives for targeting RAF kinase in human cancer (2017, NA)
• HEK293T cells has several metabolic pathways affected by vitamin D (2017, NA)
• Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade (2017, Homo sapiens,Mus musculus,Hepatitis B virus)
• PKM2 in carcinogenesis and oncotherapy (2017, NA)
• NF-kB/SCD1 pathway based on [, ] (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Metarhizium anisopliae)
• Implication from RAS/RAF/ERK signaling pathway increased activation in epirubicin treated triple negative breast cancer (2017, NA)
• Salvianolic acid B protects against diabetic atherosclerosis via the Nrf2 signalling pathway (2017, Candida dubliniensis,herbal medicine,Curcuma longa,Salvia miltiorrhiza,Ginkgo biloba,Cinchona pubescens,Ligusticum sinense,Rehmannia glutinosa,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• NFKB signalling pathway is involved in the diabetic atherosclerosis (2017, Candida dubliniensis,herbal medicine,Curcuma longa,Salvia miltiorrhiza,Ginkgo biloba,Cinchona pubescens,Ligusticum sinense,Rehmannia glutinosa,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Effect of the Hh signaling pathway on the regulation of proliferation and differentiation of SSCs in mammals (2017, Mus musculus,Rattus norvegicus,Bos taurus,Paraechinus aethiopicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Apoptotic and necroptotic mechanisms (2017, NA)
• Prior knowledge network (PKN) derived from public resources, including interactions connecting nodes which are measured (in blue) or perturbed (stimulated in green and inhibited in red) in the experimental data (2017, NA)
• Pathways of activation of naïve CD4+CD25+ T regulatory cell (Treg) (tTreg) (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins (2017, NA)
• Signaling in human glioblastoma cell lines after treatment with vascular endothelial growth factor (VEGF), irradiation and axitinib (2017, NA)
• Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand (2017, NA)
• Alterations to the phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway and outcome prediction in ovarian clear cell carcinoma (OCCC) (2017, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples)
• Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury (2017, Canis lupus familiaris,Homo sapiens)
• EGFR pathway and mechanism of action of osimertinib.Abbreviation: EGFR, epidermal growth factor receptor; TGF, transforming growth factor (2017, Homo sapiens,Macaca fascicularis,Mus musculus,Panthera tigris,NA)
• Small GTPases in endothelial barrier regulation (2017, NA)
• DAMP/ TLR/ inflammasome interactions (2017, NA)
• Diagram of CPT inhibiting IGF‐1/AKT/mTOR pathway via suppressing the ERA in breast cancer (2017, Armoracia rusticana,Zea mays,Salvia miltiorrhiza,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Phenes raptor)
• Mechanism of QE action (2017, NA)
• Proposed model of TCR-CXCR4–mediated stabilization of cytokine mRNA transcripts (2017, Homo sapiens)
• Mammalian target of rapamycin pathway (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens)
• Illustration describing the role of HPV E6/E7 oncogenes and HPV E6/E7 siRNA with cisplatin (CDDP) plus paclitaxel (PTX) therapy on HPV-infected cervical cancer cell fates (2017, NA)
• Pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury (2017, Canis lupus familiaris,Homo sapiens)
• Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing (2017, NA)
• MinePath viewer for BM20 region normal versus high Alzheimer's disease based on the CERAD classification (2017, NA)
• Figure depicts search for similar structures in chemical space (2017, Staphylococcus aureus,Xanthomonas citri,Kutzneria albida DSM 43870,Bathymaster signatus,Homo sapiens)
• miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis (2017, Homo sapiens,Mus musculus,Bos taurus)
• Metabolic control involved in aging and on the cardiovascular system (2017, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae)
• Gpr17 signaling pathway following lysolecithin insult (2017, NA)
• Chronic effect of exercise on the ER stress-associated apoptosis and inflammation (2017, NA)
• ER stress-mediated apoptosis and inflammation in cardiovascular disease (2017, NA)
• Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility (2017, Homo sapiens,Macaca mulatta,Pan troglodytes,Chlorocebus aethiops,Callithrix jacchus,Papio anubis,Gorilla gorilla,Hylobates sp.,Pongo pygmaeus,Saimiri sciureus,Aotus trivirgatus,Pan paniscus,Nomascus leucogenys,Saguinus imperator,Gorilla gorilla gorilla,Lagothrix lagotricha,Symphalangus syndactylus,Alouatta sara,Cercopithecus wolfi,Colobus guereza,Cercopithecus mitis,Pithecia pithecia,Callithrix geoffroyi,Allenopithecus nigroviridis,Lophocebus aterrimus,Lophocebus albigena,Leontocebus fuscicollis,Plecturocebus moloch,Erythrocebus patas,Hylobates lar,Pongo pygmaeus pygmaeus,Salmonella enterica subsp. enterica serovar Typhi,Alocasia macrorrhizos)
• HFE and classical MHC I molecules present homologous structures and are synthesized and folded within the endoplasmic reticulum (2017, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica subsp. enterica serovar Typhi,Yersinia enterocolitica,Vibrio vulnificus,Human gammaherpesvirus 4,Enterovirus C,Homo sapiens,Mus musculus)
• Schematic presentation of the mechanism for shell biomineralization mediated by the TGFB/BMP signaling pathway in molluscs (2017, Pinctada fucata,Homo sapiens)
• Mechanism of skin dopaminergic sensory modulation (2017, Bos taurus,Oryctolagus cuniculus,Halichoerus grypus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Centruroides exilicauda)
• COX-2/PGE2pathway in colitis-associated CRC (2017, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Characterization of network connectivity between highly expressed interferon (IFN) response genes (2017, Homo sapiens,unidentified influenza virus)
• Microarray pathway network (2017, Homo sapiens,Mus musculus)
• MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis (2017, Escherichia coli,Escherichia coli SCD1,Homo sapiens,Mus musculus,Bos taurus,vectors,Adeno-associated virus,Acanthobothrium sp. 1)
• Wnt/FZD4 signaling pathways through the interaction of miR-204 with FZD4-miR-SNP (rs713065) variant in NSCLC cells (2017, Homo sapiens,Mus musculus,Sequoia sempervirens)
• NCL expression affects cholesterol synthesis (2017, NA)
• Microglial responses to ischemia/reperfusion based on our in vitro and in vivo datasets (2017, NA)
• The MAPK pathway (2017, NA)
• TF-FVIIa-dependent PAR2-activated signaling pathway that accounts for Beta-catenin accumulation and expression of metastatic proteins leading to enhanced migration and invasion of human breast cancer cells (2017, NA)
• Proposed signaling events involved in PDGF-enhanced matrix contraction (2017, Bos taurus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• CircRNAs and the related signaling pathways in human cancers (2017, NA)
• Integration of phytochemicals and phytotherapy into cancer precision medicine (2017, NA)
• Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer (2017, NA)
• Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer (2017, NA)
• Adenosine A2b receptor promotes tumor progression of bladder urothelial carcinoma by enhancing MAPK signaling pathway (2017, NA)
• Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NFKB signaling pathway (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Adeno-associated virus)
• Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ASK1/p38 signaling pathway in cervical cancer cells (2017, NA)
• Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC) (2017, NA)
• CD54+ rabbit adipose-derived stem cells overexpressing HIF-1A facilitate vascularized fat flap regeneration (2017, NA)
• Interactions of ALS/FTD associated genes with autophagy pathway (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Danio rerio)
• Aurora kinase plus BTK blockade inhibits the chronic active BCR pathway and induces apoptosis in DH/DE-DLBCL (2017, NA)
• Model of Bcl3 activation (2017, Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Escherichia coli O55,Homo sapiens,Oryza sativa,vectors)
• The influence of Notch and Wnt pathways in the oncogenesis and stemness maintenance of breast cancer cells in the absence of estrogen (2017, Homo sapiens,Human papillomavirus)
• Gene coexpression network for trans-1,4-polyisoprene biosynthesis involving mevalonate and methylerythritol phosphate pathways in Eucommia ulmoides Oliver (2017, Eucommia ulmoides)
• T cell receptor (TCR) signaling pathway in melanoma (modified from the BioCarta database) (2017, Vaccinia virus,Cowpea mosaic virus,Homo sapiens,Mus musculus,Listeria monocytogenes,Phoma herbarum,NA)
• Capturing Human Naïve Pluripotency in the Embryo and in the Dish (2017, Homo sapiens,Mus musculus)
• Molecular hierarchical regulation of apoptosis, calcium, the UPR and autophagy by the BCL-2 family of proteins (2017, NA)
• The apoptosis regulatory network under ER stress (2017, NA)
• Complement system as a biomarker of disease activity and response to treatment in multiple sclerosis (2017, NA)
• CAMP signalling pathway in cardiac myocytes (2017, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Schematic presentation of the fusion-activated Ca2+ entry (FACE) (2017, NA)
• Molecular interactions in the Akt/mTOR signaling pathway.IP3K: Inositol-triphosphate 3-kinase; PDK: phosphoinositide-dependent kinase; TSC: tuberous sclerosis complex; Rheb: Ras homolog enriched in brain; mTOR: mammalian target of rapamycin (2017, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Early and lethal neurodegeneration with myasthenic and myopathic features (2017, NA)
• Amino acid degradation in I (2017, Anaplasma phagocytophilum,Ixodes scapularis,Homo sapiens)
• Amino acid synthesis in I (2017, Anaplasma phagocytophilum,Ixodes scapularis,Homo sapiens)
• Simplified scheme of chromatin changes in response to double-strand break (DSB) occurrence highlighting a central role of the ATM kinase (2017, NA)
• IRS4 interferes with BMP signal transduction and functions as a novel regulator of BMP signalling and myogenesis (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Moloney murine leukemia virus,Human adenovirus 5,Homo sapiens,Danio rerio)
• Basic preferences of DC metabolism (2017, Homo sapiens,Mus musculus,Ambrosia artemisiifolia)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Cardioprotective effects of macitentan (2017, NA)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• HOXB9 facilitating the formation of a hypertrophic scar (2017, NA)
• TGFB signaling induced apoptosis is modulated by the UPR cascade (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Ambystoma mexicanum)
• CLDN6-related signaling pathways, identified using KEGG pathway searches (2017, NA)
• Impact of diet-derived signaling molecules on human cognition (2017, NA)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Schematic overview of effects of metformin on gene expression and metabolism in human adrenal H295R cells, focused on mitochondria and steroidogenesis (2017, NA)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Schematic overview of the molecular network involved in VSV oncoselectivity (2017, Human alphaherpesvirus 1,Vesicular stomatitis virus,Vaccinia virus,Human T-cell leukemia virus type I,Moloney murine leukemia virus,Measles morbillivirus,Betapolyomavirus macacae,Reovirus sp.,Human adenovirus 5,Foot-and-mouth disease virus,Human rhinovirus sp.,Myxoma virus,Poliovirus 2,rhinovirus A2,Vaccinia virus GLV-1h68,Maraba virus,Vaccinia virus Ankara,Homo sapiens,Mus musculus,Canis lupus familiaris,Scutellaria baicalensis,NA,NA,NA,NA)
• Simple Wnt/Beta-catenin pathway involving CEMIP (2017, Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,Danio rerio)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• This adipogenic gene network is centered on the up-regulated transcription factor CEBPA and interactions with several other transcription regulators (a) (2017, Homo sapiens,Gallus gallus)
• Interactions of two transcription factors (PPARG and PPARD) and their direct target genes that control lipid metabolism in abdominal fat of juvenile HG and LG chickens (2017, Homo sapiens,Gallus gallus)
• Cellular processes governed by p97 (2017, NA)
• H. pylori cag-T4SS-dependent, NFKB-driven innate immune response in gastric epithelial cells (2017, NA)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Design of disease network based on mRNA expression analysis and effects of cytokines, chemokines and growth factors described in the literature (2017, Homo sapiens,Mus musculus)
• Signaling pathways mediated by high or mild oxygen on kallistatin regulation (2017, NA)
• PMSC differentiation into skeletal muscle using the insulin-like growth factor system (2017, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Polyphenols modulate the HER2 pathway (2017, Malus domestica,Olea europaea,Arachis hypogaea,Camellia sinensis,Theobroma cacao,Punica granatum,Mangifera indica,Beta vulgaris subsp. vulgaris,Beta vulgaris,Citrus limon,Prunus domestica,Trifolium pratense,Nelumbo nucifera,Hippophae rhamnoides,Solanum nigrum,Hibiscus sabdariffa,Melissa officinalis,Pinus radiata,Morinda citrifolia,Epimedium koreanum,Ribes nigrum,Prunus spinosa,Agrimonia pilosa,Terminalia catappa,Prunus serotina,Salvia chinensis,Pimenta dioica,Petasites japonicus,Hypogymnia physodes,Mus musculus,Rattus norvegicus,Helicobacter pylori,Zika virus,West Nile virus,Francisella tularensis,Homo sapiens)
• Summary of the toxic mechanisms of ZEA on breast cancer cell growth with antagonistic effects posted by AFB1 (2017, Zea mays,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Bos taurus)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome (2017, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens)
• Subtyping Chronic Obstructive Pulmonary Disease Using Peripheral Blood Proteomics (2017, Homo sapiens)
• Modular Schema of the Stress Response Network (2017, NA)
• Cooperation of 20HE, IS, and TOR signaling pathways in the regulation of fly larva growth and development (2017, NA)
• BER pathway is essential in the nervous system (2017, NA)
• Possible apoptotic pathway induced by photoactivated ZnPcSmix in monolayer cells 24 h post PDT (2017, Homo sapiens,Mus musculus,Bos taurus)
• Signal transduction initiated by transforming growth factorB1 (TGFB1) (2017, Homo sapiens)
• Possible apoptotic pathway induced by photoactivated ZnPcSmix in MCTSs 24 h post PDT (2017, Homo sapiens,Mus musculus,Bos taurus)
• Impact of glucocorticoid on neurogenesis (2017, Mus musculus,Rattus norvegicus,Homo sapiens)
• Diagrammatic representation of constitutively activated TGF-Beta-signaling-mediated tissue fibrosis (2017, Oryctolagus cuniculus,Ovis aries,Homo sapiens,Mus musculus,Zea mays)
• Noncanonical GLI1 signaling sustaining LAC growth and CSC maintenance (2017, NA)
• Proposed mechanism by which CoQ10H2 improves metabolic function and inhibits insulin resistance in KKAy mice (2017, NA)
• Schematic summary of the interleukin-6 (IL-6)/STAT3 signaling pathway, highlighting its central role in regulating the expression of multiple genes and cellular functions in metastatic breast cancer cells (2017, Oryctolagus cuniculus,Ovis aries,Equus caballus,Mus musculus,Rattus norvegicus,Nigella sativa,Leptospermum scoparium,Homo sapiens,Apis mellifera)
• Intracellular NAD+ metabolism in eukaryotic cells (2017, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Escherichia coli)
• Illustration of the complement activation pathway with annotations for quantified glomerular proteins in progressive versus non-progressive IgAN patients (2017, NA)
• Network of genes targeted by miR-21, based on miRTarBase predictions and analysed by String (2017, NA)
• Working model illustrating the potential impact of milk exosome-derived miRNAs on the expression of p53 (2017, Bos taurus,Capra hircus,Bos primigenius,Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation (2017, NA)
• Molecular Pathway in Thyroid Cancer (2017, Homo sapiens,Mus musculus)
• In the presence of insulin/growth factor, all the growth factor binds with the receptor and activates the PI3K/AKT/SGK pathway (2017, NA)
• Global Screening of Antiviral Genes that Suppress Baculovirus Transgene Expression in Mammalian Cells (2017, Human alphaherpesvirus 1,unidentified influenza virus,Human betaherpesvirus 5,H1N1 subtype,Adeno-associated virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,H5N1 subtype,Betapolyomavirus macacae,Murid betaherpesvirus 1,H7N9 subtype,H9N2 subtype,Human T-cell lymphotropic virus,Autographa californica multiple nucleopolyhedrovirus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Wnt/Beta-catenin signing pathway (2017, Homo sapiens,Caenorhabditis elegans,Canis lupus familiaris,Xenopus laevis,NA)
• Three types of autophagy and regulatory mechanisms (2017, NA)
• Restriction factors block multiple stages in the influenza virus life cycle (2017, NA)
• GF1 mechanism of preventing ox-LDL-induced inflammatory injuries through activating A20-mediated NFKB signal pathway (2017, herbal medicine,Panax ginseng,Aralia elata,Fusarium subglutinans,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Sanguibacter keddieii)
• Biomarkers of Everolimus Sensitivity in Hormone Receptor-Positive Breast Cancer (2017, NA)
• Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders (2017, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Clostridioides difficile,Shigella flexneri,Clostridioides difficile CD3,Clostridioides difficile CD8,Homo sapiens,Mus musculus,gut metagenome,Human betaherpesvirus 5,NA)
• The alternative routes of pyruvate metabolism in Carassius (2017, NA)
• Insulin signaling pathway (2017, NA)
• Schematic diagram for MEK1-dependent and independent ERK activation (2017, NA)
• Proposed model by which CCR7 regulated NFKB/VEGF pathway and induced angiogenesis in esophageal squamous carcinoma cells (2017, Homo sapiens,Mus musculus,Gallus gallus)
• Transcriptome analysis confers a complex disease resistance network in wild rice Oryza meyeriana against Xanthomonas oryzae pv. oryzae (2016, Oryza meyeriana,Xanthomonas oryzae pv. oryzae,Xanthomonas oryzae,Arabidopsis thaliana,Oryza sativa,Glycine max,Prunus persica,Oryza sativa Japonica Group,Brachypodium distachyon,Zizania,Oryza longistaminata,Oryza brachyantha,Xanthomonas arboricola pv. pruni,NA)
• YAP mediated gene expression in liver fibrosis (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Vitis vinifera,Rhodomyrtus tomentosa,Homo sapiens)
• Modeling Cellular Noise Underlying Heterogeneous Cell Responses in the Epidermal Growth Factor Signaling Pathway (2016, NA)
• Molecular mechanisms supporting the proliferation of HCC cells despite serum withdrawal (2016, NA)
• Scheme depicting the possible mechanism of VEGFR-2-mediated vascular effects (cell proliferation, survival, migration, and enhanced permeability) related to vascular formation (2016, NA)
• Engineered nanoparticles induce cell apoptosis: potential for cancer therapy (2016, Lareunionomyces loeiensis,Allium cepa,Vasconcellea candicans,Citrus macrophylla,Undaria pinnatifida,Vitex negundo,Albizia adianthifolia,Abutilon indicum,Abutilon indicum subsp. indicum,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus,Molva molva)
• miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1 (2016, NA)
• Proposed metabolic role of RubisCO, with genes identified in the PER-1 (blue line) and WS6-1 genomes (purple line) (2016, NA)
• Simple scheme of photosynthetic energy-metabolite supply for isoprene synthesis and processes inducing oscillations in photosynthesis and isoprene emission (2016, NA)
• Starch synthesis in pollen grains (2016, Arabidopsis thaliana)
• Transcriptional regulation of glucose metabolism during active TB disease and in PBMCs stimulated with Mtb (2016, NA)
• Insulin receptor (IR) and insulin‐like growth factor 1 receptor (IGF1R) signalling pathway (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Papio hamadryas,Saccharomyces cerevisiae IR-2,Glires,Escherichia coli,Caenorhabditis elegans)
• Roles of Kv1.3-channels in the activation pathway of cellular immunity in the respiratory tract and the development of chronic obstructive pulmonary disease (COPD) (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer’s Disease (2016, NA)
• Huntington's disease pathway from KEGG database (2016, NA)
• Functional Genomics Identifies Tis21-Dependent Mechanisms and Putative Cancer Drug Targets Underlying Medulloblastoma Shh-Type Development (2016, Mus musculus,Homo sapiens)
• Adaptive Stress Responses During Tumor Metastasis and Dormancy (2016, Homo sapiens,Mus musculus)
• Mechanotransduction through integrins and primary cilia (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana)
• Working model for the regulatory function of SNIP1 SUMOylation in the TGFB signaling pathway (2016, Chlorocebus aethiops,Homo sapiens)
• Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1 (2016, NA)
• Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model (2016, NA)
• Expression of myogenes in longissimus dorsi muscle during prenatal development in commercial and local Piau pigs (2016, NA)
• Low pO2 affects the activity of biomarkers of CRC (2016, NA)
• Mechanistic pathway of KSHV infection negatively affecting lipoxin secretion (2016, Homo sapiens,Human gammaherpesvirus 8)
• TLR-4/LPS signaling pathway activated by LPS in ALD (2016, Escherichia coli,Enterococcus faecium,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Levilactobacillus brevis,Escherichia coli Nissle 1917,Lacticaseibacillus rhamnosus R0011,Mus musculus,Rattus norvegicus,Homo sapiens,Cinnamomum verum)
• Schema graph for the critical roles of KCs in the pathogenesis of ALD (2016, Escherichia coli,Enterococcus faecium,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Levilactobacillus brevis,Escherichia coli Nissle 1917,Lacticaseibacillus rhamnosus R0011,Mus musculus,Rattus norvegicus,Homo sapiens,Cinnamomum verum)
• Enzymatic steps of the P (2016, Plasmodium falciparum,Homo sapiens)
• Signaling pathways through which KOR agonism could enhance remyelination (2016, NA)
• EMS induces dendritic spine formation in the ARH (2016, NA)
• The inflammatory response to extracorporeal membrane oxygenation (ECMO) (2016, Homo sapiens,Oryctolagus cuniculus)
• Ryanodine receptor isoform-1 (RyR1) pathway (2016, Homo sapiens)
• Production of aromatic compounds via shikimate pathway in microbes (2016, NA)
• Changes in the VE response to inflammatory stimuli during sepsis (2016, Homo sapiens,Ebola virus)
• Signaling transcript profile of the asexual intraerythrocytic development cycle of Plasmodium falciparum induced by melatonin and cAMP (2016, Plasmodium falciparum,Homo sapiens)
• Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling (2016, NA)
• Evolution of the Tetrapyrrole Biosynthetic Pathway in Secondary Algae: Conservation, Redundancy and Replacement (2016, Oryza sativa,PX clade,Iris germanica,Euglena gracilis,Stramenopiles,Emiliania huxleyi,Opisthokonta,Karenia brevis,Aureococcus anophagefferens,Cyanophora paradoxa,Guillardia theta,Oxyrrhis marina,Paulinella chromatophora,Gelidium foliaceum,Kryptoperidinium foliaceum,Lepidodinium chlorophorum,Rapaza viridis,Peridinium foliaceum,Durinskia baltica,Lepidodinium viride,Plasmodium falciparum,Alveolata,Euglenozoa,Perkinsus marinus,Chromera velia,Bigelowiella natans,Phytomonas serpens,Amorphochlora amoebiformis,Centroplasthelida,Palpitomonas bilix,Danio rerio,Pelomonas sp.,Homo sapiens)
• Role of adenosine receptors in osteoclast differentiation (2016, NA)
• Comprehensive transcriptomic analysis of differentiating embryonic stem cells in response to the overexpression of Mesogenin 1 (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Plasticity Related Gene 3 (PRG3) overcomes myelin-associated growth inhibition and promotes functional recovery after spinal cord injury (2016, NA)
• Conceptual model of viral integration (2016, NA)
• (Abstract P2) (2016, NA)
• Schematic presentation shows the Adiponectin signaling pathway in neuron under normal (left) and disease (right) conditions (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus)
• Synthetic Lethality of PARP-inhibitors in BRCA Tumors (2016, NA)
• LRRC4 as a tumor suppressor in glioblastoma (2016, NA)
• IPA Canonical Pathway analysis showing the interferon signaling pathway across the NC vs (2016, NA)
• Dab2 modulation of Ras/MAPK pathway at the endosomal membranes, and Dab2 function in a feedback mechanism of the Ras/MAPK pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Zoysia japonica)
• Sweet trap in tumors: aerobic glycolysis and potential targets for therapy (2016, NA)
• Sweet trap in tumors: aerobic glycolysis and potential targets for therapy (2016, NA)
• RAS-MAPK pathway epigenetic activation in cancer: miRNAs in action (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,Diaporthe sclerotioides,Escherichia coli O6H16CFAII str. B2C,Homo sapiens,Gallus gallus,Celithemis elisa)
• Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule (2016, NA)
• Intrinsic resistance to PIM kinase inhibition in AML through p38Alpha-mediated feedback activation of mTOR signaling (2016, NA)
• Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis, and Alzheimer’s disease (2016, Porphyromonas gingivalis,Homo sapiens)
• Proteomic profile of the Bradysia odoriphaga in response to the microbial secondary metabolite benzothiazole (2016, Bradysia odoriphaga,Drosophila melanogaster,Trypanosoma cruzi,Aedes aegypti,Anopheles gambiae,Entamoeba histolytica,Tribolium castaneum,Aedes albopictus,Nilaparvata lugens,Culex quinquefasciatus,Clonorchis sinensis,Aphis gossypii,Lutzomyia longipalpis,Euphausia superba,Anopheles aquasalis,Phlebotomus papatasi,Anopheles darlingi,Mayetiola destructor,Culicoides sonorensis,Belgica antarctica,Culicoides variipennis,Nyssomyia intermedia,Chironomus riparius,Coquillettidia perturbans,Simulium vittatum,Anopheles sinensis,Corethrella appendiculata,Culicoides nubeculosus,Ditylenchus destructor,Argopecten purpuratus,Simulium guianense,Simulium nigrimanum,Rhynchosciara americana,Chironomus kiiensis,Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Glycine max,Candida albicans,Cucumis sativus,Sclerotinia sclerotiorum,Phytophthora capsici,Musa ABB Group,Musa x paradisiaca,Allium schoenoprasum,Nitraria tangutorum,Bacillus subtilis,Bacillus subtilis At2,Paenibacillus polymyxa,Pseudomonas chlororaphis,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Transductional pathways associated with the activation of the 5-HT1AR overexpressed in non-neuronal cell lines (2016, NA)
• Transductional pathways associated with 5-HT1A receptor (5-HT1AR) activation in neuronal and neuronal cell lines (2016, NA)
• Some of the known pathways linking DDR to autophagy (2016, Caenorhabditis elegans,Dictyostelium discoideum,Amoebozoa,Mus musculus,Saccharomyces cerevisiae,Arabidopsis thaliana,Cricetulus griseus,Homo sapiens)
• Network model for CTNNB1 and related genes (2016, Homo sapiens,Mus musculus,Helicobacter pylori,Opsanus beta)
• Network model for CTNNB1 (2016, Homo sapiens,Mus musculus,Helicobacter pylori,Opsanus beta)
• Signaling pathway of liver fibrogenisisThe injured liver produces various cell factors, which can activate transforming growth factor beta (TGFB) and platelet-derived growth factor beta (PDGFB), and bone morphogenetic protein (BMP) (2016, NA)
• Schematic model of the three apoptosis signaling pathways (2016, Homo sapiens)
• Positive regulatory signaling for Tfh differentiation (2016, NA)
• Model for mechanosensitive P2X7/IL-3 signaling in neurons (2016, NA)
• Diagram depicting kinase pathways activated by gp120 (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Lareunionomyces loeiensis,Doryteuthis pealeii)
• Hydrogen sulfide (H2S) regulating mesenchymal stem cell (MSC) function (2016, NA)
• Conceptual model how soil S status affects GSL accumulation in Brassica crops (2016, NA)
• Factors Implicated in Insulin/Growth Factor-Induced Regulation of Mammalian or Mechanistic Target of Rapamycin (mTOR) Complex-1 (mTORC1) (2016, NA)
• mRNA changes in nucleus accumbens related to methamphetamine addiction in mice (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Diaporthe sclerotioides,Vibrio cholerae,Phytomonas oxycareni)
• Roles of Nanog in Cancer (2016, NA)
• AE alleviates hypoxia-induced retinal angiogenesis through suppression of the HIF-1A/VEGF signaling pathway (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Rheum tanguticum,Homo sapiens,Danio rerio)
• Major autophagic regulatory signalling pathways (2016, NA)
• Schematic indicating the role of cellular and EBV miRNAs in EBV latency and reactivation (2016, NA)
• An ancient role for nitric oxide in regulating the animal pelagobenthic life cycle: evidence from a marine sponge (2016, Amphimedon queenslandica,Paracentrotus lividus,Dictyostelium discoideum,Ciona intestinalis,Lymnaea stagnalis,Crepidula fornicata,Hydroides elegans,Phestilla sibogae,Tethya wilhelma,Ephydatia muelleri,Arabidopsis thaliana,PX clade,Cannabis sativa,Amphiroa fragilissima,Homo sapiens,Oryctolagus cuniculus,NA)
• Schematic model to summarize Wnt5/PKC signaling pathway in lung cancer (2016, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis BCG str. China,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Molecular pathways implicated in the neuroprotective effects of bile acids in neurodegenerative disease models (2016, NA)
• Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis (2016, Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Raphanus sativus)
• Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer's disease story? (2016, NA)
• Mechanism of action of metformin (2016, Homo sapiens)
• Schematic overview of proposed molecular host-symbiont interactions (2016, Olavius algarvensis,Homo sapiens)
• Identification of Conserved Moieties in Metabolic Networks by Graph Theoretical Analysis of Atom Transition Networks (2016, NA)
• Viral sensing pathways that trigger host immune responses (2016, NA)
• Signaling pathways associated with differentially expressed proteins as identified by Pathway Studio (2016, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana,Ciona intestinalis)
• Inhibition of MAPK and NFKB signaling pathways by YopJ effectors produced by animal pathogens (2016, NA)
• Homeostasis and epidermal growth factor receptor downstream signaling pathway in keratinocyte (2016, NA)
• Schematic of tumor cell interactions in the brain (2016, Homo sapiens,Mus musculus,Taraxacum officinale)
• TLRs play critical roles in gastrointestinal inflammatory disorders at the mucosa (2016, Homo sapiens)
• Activation of EGC and induction of a reactive EGC phenotype (2016, Aspergillus janus)
• Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Gallus gallus,Melanogrammus aeglefinus,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Fasciola hepatica)
• Pyrimidine biosynthetic pathway in P enicillium spp (2016, Saccharomyces cerevisiae,Nicotiana tabacum,Zea mays,Solanum lycopersicum,Solanum tuberosum,Cucumis sativus,Aspergillus nidulans,Aspergillus niger,Neurospora crassa,Aspergillus flavus,Fusarium oxysporum,Vicia faba,Penicillium chrysogenum,Trichoderma reesei,Verticillium dahliae,Aspergillus clavatus,Penicillium oxalicum,Mortierella alpina,Penicillium digitatum,Fusarium oxysporum f. sp. lycopersici,Phycomyces blakesleeanus,Epicoccum nigrum,Picea rubens,Penicillium rubens Wisconsin 54-1255,Penicillium camemberti,Penicillium rubens,Fusarium oxysporum f. sp. radicis-lycopersici,Aspergillus nidulans var. nidulans,Penicillium decumbens,Penicillium chrysogenum var. chrysogenum,Fusarium oxysporum f. sp. vasinfectum,Penicillium glabrum,Penicillium oxalicum 114-2,Penicillium corylophilum,Homo sapiens,Pseudomonas aeruginosa,Meloidogyne javanica,NA,NA)
• Reprogramming of the glycolytic pathway in cancer cells (2016, NA)
• Signaling pathways related to the activity of oxaliplatin and 5-FU for colon cancer cell lines (2016, NA)
• Schematic model of downstream signaling after GPCR activation (2016, Mus musculus,Homo sapiens)
• The metabolic pathway in C (2016, NA)
• The metabolic pathway in E (2016, NA)
• Importance of the type I IGF receptor and PI3-kinase/Akt pathway in the IGF-protection from anoikis (2016, NA)
• Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte (2016, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus asinus,Homo sapiens,Mus musculus)
• Uncovering New Pathogen–Host Protein–Protein Interactions by Pairwise Structure Similarity (2016, NA)
• Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone (2016, NA)
• Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone (2016, NA)
• Molecular signaling and the advantages of Warburg (2016, NA)
• Toll-like receptor 2’s signalling pathways contributing to hepatocarcinoma (2016, NA)
• Toll-like receptor 4’s signalling pathways influencing hepatocarcinogenesis (2016, NA)
• Toll-like receptor 9’s signalling pathways influencing hepatocarcinoma (2016, NA)
• Metabolic pathway map of Parachlorella kessleri (2016, Parachlorella kessleri)
• Length of interaction alters the activation of specific transcription factors (2016, Homo sapiens,Mus musculus,Listeria monocytogenes)
• Molecular effects of caloric restriction (2016, NA)
• cAMP/PKA/CREB/GLT1 signaling involved in the antidepressant-like effects of phosphodiesterase 4D inhibitor (GEBR-7b) in rats (2016, NA)
• Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1 (2016, NA)
• Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway (2016, NA)
• Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Cavia porcellus,Cricetus cricetus,Triticum aestivum,Arachis hypogaea,Homo sapiens,Gallus gallus)
• Hepatitis C virus life cycle (2016, NA)
• Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells (2016, Saccharomyces cerevisiae,herbal medicine,Panax ginseng,Paris polyphylla,Trillium tschonoskii,Polygonatum cyrtonema,Paris polyphylla var. yunnanensis,Paris axialis,Homo sapiens,Bos taurus)
• Emerging targets for glioblastoma stem cell therapy (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,clinical samples,Callanthias legras)
• Regulation of actin cytoskeleton pathway (2016, NA)
• Interaction between neurotrophins and VEGF (2016, NA)
• Alternative NOTCH pathway representations (2016, NA)
• Global view of biological processes and molecular functions of HDL proteins (2016, NA)
• PTP1B regulates cell contractility and spreading (2016, NA)
• Schematic diagram illustrating the proposed mechanism of action for CB1-mTORC1 interaction in islets and its physiological relevance in vivo (2016, NA)
• Scheme illustrating the proposed HNO‐TRPA1‐CGRP signalling pathway at meningeal arteries innervated by trigeminal afferent nerve fibres (AD/C) (2016, Rattus norvegicus,Homo sapiens)
• Mitogen Activated Protein Kinase (MAPK) pathway signaling (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Human alphaherpesvirus 1)
• Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NFKB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice (2016, NA)
• Molecular and cellular mode of action of energy disruptors (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Lipid rafts as platforms for cell signaling (2016, NA)
• Ingenuity Pathway Analysis (IPA) illustration showing upstream regulation of the pathway for NFKB (2016, Mus musculus,Pseudomonas aeruginosa,Homo sapiens)
• Schematic Diagram Depicting the Proposed Role of P-gp in the Formation of Peritoneal Adhesions following an Abdominal Operation (2016, NA)
• Targeting of the genes and pathways for stem cell maintenance by miR-200 family miRNAs (2016, NA)
• Activation of the canonical Wnt signaling pathway by the breast CSC-specific miRNAs (2016, NA)
• Liver fibro-carcinogenesis-related EMT and phospho-Smad signaling during chronic liver disease (2016, NA)
• Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway (2016, NA)
• Gene members (green rectangle) in the PPAR signaling pathway that are regulated by maternal high fructose in the male offspring kidney at one day of age (red stars) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,NA)
• The tryptophan (TRP) metabolic pathway (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Panax ginseng,Mus sp.,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• EGFR function in hepatocytes and Kupffer cells during hepatocellular carcinoma (HCC) formation (2016, Homo sapiens,Mus musculus)
• Outline of melatonin biosynthesis and function (2016, Danio rerio,Xenopus laevis,Oncorhynchus mykiss,teleost fish,Oryzias latipes,Carassius auratus,Salmo salar,Dipnomorpha,Xenopus tropicalis,Dicentrarchus labrax,Gadus morhua,Tetrapoda,Sparus aurata,Tetraodon nigroviridis,Zootoca vivipara,Fundulus heteroclitus,Gasterosteus aculeatus,Petromyzon marinus,Cynoglossus semilaevis,Anolis carolinensis,Solea senegalensis,Latimeria chalumnae,Callorhinchus milii,Actinopterygii,Astyanax mexicanus,Poecilia formosa,Esox lucius,Myxini,Coelacanthimorpha,Sinocyclocheilus anshuiensis,Periophthalmus kalolo,Protacanthopterygii,Hippocampus spinosissimus,Boleophthalmus boddarti,Boleophthalmus pectinirostris,Periophthalmus magnuspinnatus,Scleropages formosus,Epinephelus malabaricus,Ovis aries,Ornithorhynchus anatinus,Balaenoptera acutorostrata,Balaenoptera acutorostrata scammoni,Drosophila melanogaster,Branchiostoma lanceolatum,Losaria coon,Homo sapiens,Pan troglodytes,Mus musculus,Citrus aurantiifolia)
• EGFR transactivation by GPCR (2016, NA)
• Cell death pathways after irradiation (2016, Homo sapiens)
• Induction of DNA repair by EGFR signaling (2016, Homo sapiens)
• The role of HSP27 in the sensitivity to gemcitabine in human pancreatic cancer (2016, NA)
• Wnt/Beta-catenin signaling in kidney injury and repair: a double-edged sword (2016, NA)
• Evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies (2016, Homo sapiens,Mus musculus)
• TNFAlpha-related signal transduction pathway participating in the differentiation of skin appendages (2016, NA)
• Interaction of proteins involved in signal transduction via the TNFAlpha-related signal transduction pathway (based on http://string-db.org, simplified) (2016, NA)
• Placental mTOR as a nutrient sensing signaling pathway (2016, NA)
• Novel NFKB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,herbal medicine)
• H218O incorporation into PC lipids (2016, NA)
• Alterations in the levels of metabolites and mRNA transcripts that are crucial to energy metabolism in NAF-1(−) MCF-7 cells (2016, NA)
• Transcriptional Analysis of T Cells Resident in Human Skin (2016, NA)
• Transcriptional Analysis of T Cells Resident in Human Skin (2016, NA)
• FoxC2 Enhances BMP7-Mediated Anabolism in Nucleus Pulposus Cells of the Intervertebral Disc (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,adeno-associated virus 2)
• Blockade of KCNN4 by Clt accelerates wound healing at least in part by transactivation of the PI3K pathway (2016, NA)
• Regulatory mechanism of lncRNAs (2016, NA)
• MAPK signaling pathway, determined using the Kyoto Encyclopedia of Genes and Genomes database (2016, NA)
• BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway (2016, NA)
• Strategies evolved by Staphylococcus aureus to counteract innate immune response (2016, NA)
• Wnt signaling interacts with intercellular junction components (2016, NA)
• Pim-1 kinase as cancer drug target: An update (2016, NA)
• Antitumor mechanism of metformin (2016, NA)
• Ionizing Radiation Induces Altered Neuronal Differentiation by mGluR1 through PI3K-STAT3 Signaling in C17.2 Mouse Neural Stem-Like Cells (2016, NA)
• Activation of Dll4/Notch Signaling and Hypoxia-Inducible Factor-1 Alpha Facilitates Lymphangiogenesis in Lacrimal Glands in Dry Eye (2016, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Homo sapiens,Mouse mammary tumor virus)
• Transcriptional regulation of mitophagy (2016, Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Mus musculus,Drosophila melanogaster,Hepatitis B virus)
• Analysis of metabolic pathways among the microbial community (2016, NA)
• Schematic working model for presumed mechanisms underlying the effects of Mus81 knockdown on hepatocellular carcinoma (HCC) cells in response to chemotherapeutic drugs (2016, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Schizosaccharomyces pombe)
• Gatekeepers in the Mouse Ophthalmic Artery: Endothelium-Dependent Mechanisms of Cholinergic Vasodilation (2016, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Diaporthe sclerotioides,Centruroides margaritatus,NA)
• Approaches for xylose-based fatty alcohol production and improvement (2016, NA)
• Schema of signaling pathway involved in IL-1Beta-induced inflammation in microglia (2016, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana,Helicobacter pylori,NA)
• Synaptic binding partners and signaling pathways of BAI adhesion-GPCRs (2016, NA)
• Β-catenin (TNFR – TNFA receptor) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus)
• Changes in genes associated with epithelial-to-mesenchymal transition after radiation (2016, NA)
• Wnt/Beta-catenin signaling in ASDs (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• Regulation of interconnected stem cell signaling nodes by the AR (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• RNA selectivity and RIG-I activation (2016, NA)
• Canonical JAK-STAT signaling pathway (2016, NA)
• Crosstalk between Wnt, Notch, and JAK-STAT signaling pathways (2016, NA)
• Possible cell death mechanism pathway of antcin K in human liver cancer Hep 3B cells (2016, Armoracia rusticana,Agaricus bisporus,Allium sativum,Lantana camara,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Hepatitis B virus,Calloplesiops altivelis,NA,NA)
• Network of TREM1 and PTGS2 (COX-2) upstream regulators and their target molecules, evaluated in the peripheral blood cells of breast cancer patients compared with healthy donors (Ingenuity Pathway Analysis) (2016, NA)
• Mitochondria-synapse signaling loop is modulated by glucocorticoids (2016, NA)
• Signaling pathways demonstrating the link between Gq-coupled receptors and induction of autoimmunity (2016, NA)
• Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90 (2016, NA)
• JAK-STAT signaling contributes to the pathogenesis of MPNs (2016, NA)
• Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease (2016, NA)
• Inactivation of nuclear GSK3B by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response (2016, NA)
• Sirolimus and CNI impact on insulin signaling pathway (2016, NA)
• Estrogen Enhances the Cell Viability and Motility of Breast Cancer Cells through the ERAlpha-ΔNp63-Integrin B4 Signaling Pathway (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• BMI1 regulates BCSC (2016, NA)
• Mechanism mediating ceramide inhibitory action on insulin signaling in myotubes (2016, Mus musculus,Mus caroli,Homo sapiens)
• Notch signaling on T cells (2016, NA)
• G1 or G2 APOL1-induced cytotoxicity mediated by K+ efflux and activation of SAPK signaling (2016, Homo sapiens)
• Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells (2016, NA)
• Mechanisms of continued AR signalling in CRPC , , , (2016, Homo sapiens,Mus musculus)
• Colorectal cancer characterization and therapeutic target prediction based on microRNA expression profile (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Functional interpretation of the IL-6 gene signature and its relationship to the three main downstream pathways of IL-6.Notes: The 17 genes are part of the Jak-STAT IL-6 downstream pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Gallus gallus,Raphanus sativus)
• IDO pathway effects to slow the immune response, anti-CTLA-4 blocks CTLA-4 from binding CD80 (2016, Homo sapiens)
• Expression of genes involved in the fibroblast growth factor (FGF) signaling pathway during goat pre-implantation development (2016, Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus)
• Cyclin D/cyclin-dependent kinase (CDK)4/6/retinoblastoma (Rb) Pathway and the cell cycle (2016, NA)
• Role of RAS enzymes in the EGFR signaling pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer (2016, NA)
• BRAF(V600E)-directed recruitment of MAFG and its corepressors to CIMP and HIM gene promoters (2016, NA)
• Proteomics analysis of exosomes from EBV-driven LCLs compared with exosomes from CD40L-stimulated B cells shows “immune system process” as the most represented pathway, and an enrichment in “integrin-mediated signaling” and “cell adhesion” terms (2016, NA)
• Molecular mechanisms of survivin in tumorigenesis (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Highest confidence network constructed with differentially methylated genes by proton beam treatment on the MCF-7 cell (2016, Mus musculus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Dipturus trachyderma)
• Shigella exploits Ca2+signaling to delay cell death and to dampen inflammation (2016, NA)
• ApoCanD: Database of human apoptotic proteins in the context of cancer (2016, Homo sapiens)
• Paediatric obstructive sleep apnoea syndrome (OSAS) is associated with tonsil colonisation by Streptococcus pyogenes (2016, NA)
• RSV infection induces a response balanced by pro-inflammatory and tissue repair pathways (2016, NA)
• Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model (2016, NA)
• Sclerostin and the Wnt/Beta-catenin signalling pathway (2016, Homo sapiens,Macaca fascicularis,Mandrillus leucophaeus,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus)
• TLR signaling pathway genes (2016, Bos taurus,Sus scrofa,Sus scrofa domesticus,Phacochoerus africanus,Babyrousa babyrussa,Sus verrucosus,Sus barbatus,Sus celebensis,Potamochoerus porcus,Potamochoerus larvatus,Saccharomyces cerevisiae,Embryophyta,Daucus carota,Populus tremula,Gallus gallus,Danio rerio,Xenopus tropicalis,Homo sapiens,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Salmonella enterica subsp. enterica serovar Typhimurium,Pan troglodytes,Mus musculus)
• Mitogen activated protein kinase (MAPK) signalling pathways mediate responses to a variety of stimuli, including ROS (2016, NA)
• Learned network (2016, Homo sapiens,Mus musculus,Human gammaherpesvirus 8)
• Central sub-network of breast cancer (2016, NA)
• HIV infection of brain capillary pericytes triggers a biphasic metabolic response (2016, NA)
• Model proposed in this study (2016, Mus musculus,Danio rerio,Homo sapiens)
• The Akt pathway and downstream effectors (2016, NA)
• Identification of Targets of CUG-BP, Elav-Like Family Member 1 (CELF1) Regulation in Embryonic Heart Muscle (2016, NA)
• Ingenuity pathway analysis of GH signaling after hepatectomy (2016, NA)
• PI3K signaling and common mutations related with ASD and schizophrenia (2016, NA)
• Gene networks (2016, NA)
• Phosphoglycerolipid structure and biosynthetic pathway (2016, NA)
• Scheme of molecular mechanisms that obesity can influence during carcinogenesis of the mammary gland (2016, NA)
• Scheme of the molecular mechanisms that ethanol consumption can influence during carcinogenesis of the mammary gland (2016, NA)
• Epithelial/mesenchymal status of MCs is due to the balance of signals delivered by multiple receptors (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Astragalus membranaceus)
• Schematic of S1P signaling (2016, NA)
• Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway (2016, NA)
• Canonical Wnt signalling pathway (2016, NA)
• Pathways for molecular targeting in prostate cancer radiotherapy (2016, NA)
• Actin associated proteins regulate YAP activity (2016, NA)
• Abbreviated pathway for the biosynthesis and metabolism of Orn in plants in connection to polyamines, amino acids, TCA cycle metabolites, and alkaloids (2016, NA)
• Stimulator of interferon genes (STING)‐mediated cytosolic DNA sensing pathway (2016, NA)
• Metabolic regulation of mitochondrial transport and mitophagy (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• RAS–RAF–MEK–ERK pathway and the potential sites of action of RAF inhibitors and MEK inhibitors discussed in the text (2016, Homo sapiens)
• Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor chemoresistance (2016, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Diagram summarizing the reviewed mechanisms by which CCR9 induces different aspects of tumor metastasis (2016, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• KEGG pathway map (cin04310) of the WNT Signaling Pathway with DE genes indicated (2016, NA)
• Proposed model illustrating the mechanisms by which AMPK functions as a central metabolic switch that governs glucose and lipid metabolism and activation of this master switch serves as a danger signal to alert NKT cells to infection and malignancy (2016, NA)
• Phosphoproteins down-regulated in PCP and PCPPPI compared to Sal and SalPPI, respectively, which were significantly enriched in LTP signaling pathway (2016, NA)
• De Novo Transcriptome Assembly and Characterization for the Widespread and Stress-Tolerant Conifer Platycladus orientalis (2016, NA)
• Blood vessel structure and main endothelial functions (2016, NA)
• Mechanism of fucoidan action.Notes: Fucoidan inhibited HSCs activation that could secrete TGFB1, thus inhibiting the downstream TGFB1/Smads pathway (2016, Fucus vesiculosus,PX clade,Olea europaea,Viola sororia,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Currently approved and available IBD therapies include: four anti-TNF agents, namely infliximab, adalimumab, certolizumab pegol, and golimumab, and two anti-integrin agents, natalizumab and vedolizumab (2016, NA)
• Platycodin D‐induced G2/M phase cell cycle arrest in cancer cells (2016, NA)
• Gene regulation by peroxisome proliferators (PPARs): the most significant pathway from Crohn’s disease (CD) (2016, Homo sapiens,Mus musculus,Mycobacterium tuberculosis)
• Inflammation in SCD (2016, NA)
• AAV backbone alone has no effect on interferon activation (2016, NA)
• Sinergistic effects of PARP inhibitors and mAbs targeting EGF, HER2 and VEGF pathways (2016, Homo sapiens)
• The signaling pathway affecting rRNA synthesis following resistance exercise and where CWI might interfere with this pathway (2016, NA)
• Proposed model for Usp12 function in the pathway of TCR signaling (2016, Homo sapiens,Mus musculus)
• Agrin and LRP4 are central to a chondrogenic signalling network (2016, NA)
• Putative scheme on bisphenol A (BPA) action in adipocyte (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Scheme of the role of (+)‐naltrexone and (+)‐naloxone in TLR4 signalling (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic diagram depicting the proposed signaling pathway involved in interferon-induced transmembrane protein 1 (IFITM1) upregulation in SUM149 cells (2016, NA)
• Pathway network of the 22 TSGs based on GeneMANIA (2016, NA)
• RhoGTPase switch at the cell–cell contact (2016, NA)
• Of Radiation-Induced Cellular Stress for Reactivation of Latent HIV-1 and Killing of Infected Cells (2016, Homo sapiens,Human immunodeficiency virus 1)
• Metabolism reprogramming in PDAC (2016, NA)
• Metabolic pathway alterations in PCT (2016, NA)
• Glucose and glutamine metabolism in cancer cells (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens)
• General metabolic pathways for Thermococcus paralvinellae (2016, Thermococcus paralvinellae,Homo sapiens)
• Living biointerfaces based on non-pathogenic bacteria support stem cell differentiation (2016, NA)
• Schematic depicting how PC1/3 knockdown impacts macrophage activation (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Sox2: regulation of expression and contribution to brain tumors (2016, NA)
• Antagonistic signaling by PI3K and Itpkb controls the kinetics and Notch-dependence of Beta-selection (2016, NA)
• Simplified MAPK signaling pathways (2016, NA)
• Leishmania spp (2016, NA)
• Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development (2016, Homo sapiens,Oryctolagus cuniculus)
• Canonical pathway analysis (2016, NA)
• Signaling pathways involved in diabetic nephropathy (DN) pathogenesis (2016, herbal medicine,Panax ginseng,Salvia miltiorrhiza,Allium sativum,Punica granatum,Panax notoginseng,Cinnamomum verum,Melia azedarach,Tripterygium wilfordii,Silybum marianum,Schisandra chinensis,Paeonia lactiflora,Trigonella foenum-graecum,Psidium guajava,Andrographis paniculata,Panax quinquefolius,Fallopia multiflora,Hibiscus sabdariffa,Vitis labrusca,Portulaca oleracea,Engelhardia roxburghiana,Rheum tanguticum,Rheum officinale,Carum carvi,Abelmoschus manihot,Asparagus racemosus,Cornus officinalis,Epimedium grandiflorum,Euonymus alatus,Vachellia nilotica,Eclipta prostrata,Averrhoa carambola,Rosa laevigata,Auricularia auricula-judae,Artemisia campestris,Angelica acutiloba,Piper auritum,Gymnema montanum,Aster koraiensis,Mus musculus,Rattus norvegicus,Homo sapiens,Molva molva)
• Metabolic pathway for n-butanol production via reverse Beta-oxidation in yeast (2016, Saccharomyces cerevisiae,Homo sapiens)
• Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating A5-nAChR/AKT Signaling in Human Gastric Cancer Cells (2016, NA)
• Lysine degradation pathways in mammals (2016, NA)
• Recruitment and activation of bone marrow-derived fibroblasts in renal fibrosis (2016, NA)
• Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation (2016, NA)
• Extracellular calcium-sensing receptor regulates human fetal lung development via CFTR (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Bacterial cellulose synthesis mechanism of facultative anaerobe Enterobacter sp. FY-07 (2016, Enterobacter sp.,Enterobacter sp. FY-07)
• Loss of CEACAM1, a Tumor-Associated Factor, Attenuates Post-infarction Cardiac Remodeling by Inhibiting Apoptosis (2016, NA)
• Proposed model for B cell responses in secondary lymphoid organs during DENV infection (2016, NA)
• Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice (2016, NA)
• NFKB activation pathways (2016, NA)
• NFKB signaling by oncogenic pathways in GBM (2016, NA)
• Proposed model of the involvement of Spry2 and Spry2 siRNA in TLR, IFNG receptor, and growth factor signaling pathways for suppression of M1 polarization and enhancement of M2 polarization in macrophages (2016, Porphyromonas gingivalis,Homo sapiens)
• Bioinformatics analyses reveal changes in expression of genes associated with the Death Receptor Pathway (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Psidium guajava)
• BST‐2 in viral infection: BST‐2 tethers viruses to the cell membrane and to each other (1) and (2) (2016, NA)
• Activation of nuclear factorKB: Canonical and non-canonical pathways (2016, NA)
• Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway (2016, NA)
• Fiblobrast growth factor structure and signaling network (2016, NA)
• Molecular mechanisms for the functions of estrogen receptors (2016, NA)
• Eosinophils contain and/or release a wide array of preformed and de novo synthesized mediators important for their effector functions (2016, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Eosinophils modulate the functions of a multitude of cells of the innate and adaptive immune system (2016, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Interleukin-5 plays a fundamental role in the proliferation, maturation in the bone marrow, recruitment and activation at sites of allergic inflammation of eosinophils (2016, Homo sapiens,Mus musculus,Nicotiana tabacum)
• RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity (2016, Orbicella faveolata,Nematostella vectensis,Bilateria,Hydra vulgaris,Acropora millepora,Acropora digitifera,Pocillopora damicornis,Asterias rubens,Acropora palmata,Acropora cervicornis,Porites astreoides,Orbicella annularis,Dipsastraea favus,Gorgonia ventalina,Pseudodiploria strigosa,Bacteriophage sp.,Breviolum minutum,NA,NA)
• RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity (2016, Orbicella faveolata,Nematostella vectensis,Bilateria,Hydra vulgaris,Acropora millepora,Acropora digitifera,Pocillopora damicornis,Asterias rubens,Acropora palmata,Acropora cervicornis,Porites astreoides,Orbicella annularis,Dipsastraea favus,Gorgonia ventalina,Pseudodiploria strigosa,Bacteriophage sp.,Breviolum minutum,NA,NA)
• RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity (2016, Orbicella faveolata,Nematostella vectensis,Bilateria,Hydra vulgaris,Acropora millepora,Acropora digitifera,Pocillopora damicornis,Asterias rubens,Acropora palmata,Acropora cervicornis,Porites astreoides,Orbicella annularis,Dipsastraea favus,Gorgonia ventalina,Pseudodiploria strigosa,Bacteriophage sp.,Breviolum minutum,NA,NA)
• Akt-mTORC1 signaling and the activation of M2 macrophages (2016, NA)
• ITK acts as a rheostat for the TCR signaling pathway (2016, NA)
• Regulation of Th2 Cell Immunity by Dendritic Cells (2016, NA)
• Developmental pathways are frequently activated in cancer (2016, Gallus gallus,Danio rerio,Bacteriophage sp.,Punavirus P1,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Mouse mammary tumor virus,Paraechinus aethiopicus,NA)
• Aryl hydrocarbon receptor signaling pathway is depicted with 3,3′-diindolylmethane as a model agonist (2016, NA)
• Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma (2016, NA)
• Signaling pathway of SFN in U251MG cells (2016, NA)
• Simplified pathways of synaptic transmission and effects of nitrergic posttranslational modifications (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster,Gallus gallus,prion,Human adenovirus 5)
• Example pathway (Alzheimer's disease) overlaid with gene expression data from BBB cell line (2016, Homo sapiens,Bikinia letestui)
• Wnt signaling (2016, NA)
• Mechanical signaling and tissue growth (2016, NA)
• Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm) (2016, NA)
• Ingenuity pathway analysis of miR-221 and miR-483 target genes (2016, NA)
• Signaling pathways involved in cellular response to implant materials (2016, Homo sapiens)
• Candidate driving genetic alterations and their druggability in AYA cancers (2016, Homo sapiens,Mus musculus)
• HCV induces transforming growth factor B1 through activation of endoplasmic reticulum stress and the unfolded protein response (2016, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus asinus,Homo sapiens,Mus musculus,Armoracia rusticana,NA)
• Molecular signaling pathway involved in autophagy.Notes: Autophagy responses are sensed by AMP-activated kinase (AMPK) and mTOR1 (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,prion,NA)
• Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways (2016, Homo sapiens,Rattus norvegicus,Xenopus laevis)
• Rare Copy Number Variants Identified Suggest the Regulating Pathways in Hypertension-Related Left Ventricular Hypertrophy (2016, NA)
• Metabolic intermediates regulate Yersinia virulence (2016, NA)
• Mathematical model of adrenal steroidogenesis in NCI-H295R cells (2016, Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling mechanisms through the Janus kinase (JAK)/STAT pathway and action point of a JAK inhibitor tofacitinib (2016, NA)
• Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Main parts of the biochemical regulation of the G1/S restriction point in normal (non-leukemic) cell cycle (2016, Saccharomyces cerevisiae,Iris germanica,Homo sapiens)
• G1/S restriction point alterations and deregulations in BCP-ALL (2016, Saccharomyces cerevisiae,Iris germanica,Homo sapiens)
• NO, H2S, and HNO on heart contractile function (2016, NA)
• RhoA/Rho kinase in spinal cord injury (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cardioprotective effects of NO, H2S, and HNO (2016, NA)
• Apoptosis signaling pathway mediated by chaetominine (2016, Armoracia rusticana,Aspergillus fumigatus,Cajanus cajan,Chaetomium sp.,Homo sapiens,Bos taurus,Macrothele raveni)
• Target function of MALAT-1 in cancer (2016, NA)
• Main canonical pathways induced by cigarette smoke extract (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cavia porcellus,Homo sapiens,Nicotiana tabacum)
• Scheme and coexpression network for a putative flavonol synthesis pathway in tobacco flowers (2016, NA)
• p38 MAPK regulation of the hypoxia response pathway (2016, NA)
• SOCS抑制JAK-STAT信号通路的作用机制Mechanism of SOCS inhibition of JAK-STAT signaling pathway (2016, NA)
• Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer (2016, NA)
• Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina (2016, NA)
• Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina (2016, NA)
• HTLV-1 Cell-to-Cell Transmission (2016, NA)
• Modes of action of lipids in enterovirus replication (2016, NA)
• Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer’s Disease (2016, Saccharomyces cerevisiae,Zea mays,Homo sapiens,Mus musculus,integrons)
• Genes and miRNAs involved in the regulation of the intrinsic and extrinsic apoptosis pathway (2016, Human gammaherpesvirus 8,Adeno-associated virus - 8,Homo sapiens,Mus musculus)
• Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance (2016, NA)
• Proposed model of XAV939 in WNT signaling pathway (2016, NA)
• Schematic diagram of LRP1/Wnt5a-dependent inhibition of intracellular cholesterol accumulation (2016, Mus musculus,Homo sapiens)
• Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases (2016, NA)
• Pathway map for paramylon and wax ester metabolism in E.gracilis (2016, Euglena gracilis,Homo sapiens)
• Changes in the expression levels of genes associated with cell cycle pathway in PC3 cell line after treatment with G (2016, NA)
• Ozone-induced lung inflammation and role of IL-6 signaling pathway: ozone-associated lung inflammation is primarily driven by lipid ozonation products (LOP) and generation of free radicals primarily in lung epithelial cells (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Nicotiana tabacum)
• Cross talk between ROS and MAPKs signaling pathway (2016, NA)
• Cross talk between ROS and Keap1-Nrf2-ARE signaling pathway (2016, NA)
• Phosphoinositide-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR or PAM) pathway promotes cell growth/proliferation and cell survival, and sustained metabolic activity (2016, Mus musculus,Rattus norvegicus,Oryza sativa,Citrus macrophylla,Homo sapiens,Gallus gallus,Trypanosoma brucei,NA)
• Integration of non-coding RNAs in regulation of canonical JAK/STAT network (2016, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,NA)
• Apoptosis through death receptors: a signaling pathway in TLE(HS) (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Model depicting how AMPK regulates cell fate decisions through lysosome-dependent control of Wnt signaling (2016, Homo sapiens,Mus musculus)
• miR-146a-5p and miR-155-5p mechanism of action under normal conditions and early stages of inflammation (, , ) (2016, NA)
• Pathway analysis illustrating the link between PM2.5-associated miRNAs in extracellular vesicles and biological pathways related to cardiovascular disease (2016, Homo sapiens,Rattus norvegicus,Bos taurus,Sequoia sempervirens)
• Proposed regulatory mechanism of insulin expression by the Wnt/Beta-catenin/NeuroD1 pathway in the hypothalamus (2016, NA)
• Fibroblast growth factor receptors and genes that are involved in FGF pathway were analyzed by IPA in KC iPSC compared with normal iPSC (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,Vesicular stomatitis virus,Galaxias sp. southern)
• Regulation of hepcidin antimicrobial peptide (HAMP) expression (2016, Danio rerio,Turdus migratorius,Glyptocephalus cynoglossus,Homo sapiens,Macaca fascicularis,Mus musculus,Oryctolagus cuniculus,clinical samples)
• Signature model of immunity signalling (2016, Arabidopsis thaliana,Nicotiana tabacum,Glycine max,Solanum lycopersicum,Solanum tuberosum,Triticum aestivum,Vitis vinifera,Phaseolus vulgaris,Physcomitrium patens,Peronospora farinosa,Plasmopara viticola,Erysiphe necator,Phyllosticta ampelicida,Homo sapiens,Dipturus trachyderma)
• Model illustrating balanced root hair tip growth (2016, NA)
• Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite (2016, Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Six miRNAs and their target genes that are involved in milk fat metabolism in bovine mammary gland (2016, NA)
• Tri-m-cresyl phosphate and PPAR/LXR interactions in seabream hepatocytes (2016, Danio rerio,Homo sapiens)
• Cell-type dependent regulation of AKT S473 phosphorylation by LPA: (A) Knockdown of RICTOR using a specific siRNA disrupts kinase activity of mTORC2 (2016, NA)
• Highest-scoring and fifth highest-scoring pathway maps for the last two time points post-TBI (24 and 72 h) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Hypoglossum sp. 1)
• Inhibition of Calcium-induced T Lymphocyte Apoptosis pathway (2016, NA)
• Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD) †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6tx00166a (2016, NA)
• Synthetic model of Plasmodium quiescence metabolism (2016, NA)
• Functional interaction network of the final set of 50 genes prioritized with the consensus strategy and 100 additional interacting genes (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Olea europaea,Gallirallus australis)
• Functional interaction network comprising gene sets prioritized by Limma and ML (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Olea europaea,Gallirallus australis)
• Kuijie Granule in suppressing ulcerative colitis (2016, Prunus domestica,Schisandra chinensis,Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus)
• Neutrophil Functions in Periodontal Homeostasis (2016, NA)
• This signal transduction model is general (2016, NA)
• Stability of Ensemble Models Predicts Productivity of Enzymatic Systems (2016, Escherichia coli,Thermus thermophilus,Saccharolobus solfataricus,Saccharomyces cerevisiae,Solanum tuberosum,Homo sapiens,synthetic gene)
• Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway (2016, NA)
• Top networks activated in the CPu during CIE and acute withdrawal (2016, NA)
• Both signal 1 and signal 2 are required for NLRP3 inflammasome activation (2016, NA)
• Position of miRNA targeted genes (red box) in endometrial carcinogenesis pathway (KEGG) (2016, Homo sapiens,Eucalyptus intertexta)
• Transcriptional regulators in C (2016, Caenorhabditis elegans,Homo sapiens)
• Small molecular drug and their perturbed subpathways in HCC.Notes: The rectangle nodes represent drugs, and the circle nodes represent subpathways (2016, Homo sapiens,Bos taurus,Candida dubliniensis,Metaphire sieboldi)
• Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia (2016, Mus musculus,Rattus norvegicus,Scapteromys aquaticus,Rattus rattus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Escherichia coli)
• Wnt signaling pathway (2016, Schistosoma turkestanicum,Homo sapiens)
• MELK and stathmin signaling (2016, Bos taurus,Oryctolagus cuniculus,Middle East respiratory syndrome-related coronavirus,Anticarsia gemmatalis iridescent virus,Homo sapiens,Mus musculus,Xenopus laevis)
• Wnt/Beta-catenin signaling (2016, NA)
• Wnt/planar cell polarity pathway (2016, NA)
• Wnt/Ca2+pathway (2016, NA)
• Canonical miRNA biogenesis pathway (2016, NA)
• Module network of the core network biomarkers in to investigate the bladder carcinogenic mechanisms from stage 1 to stage 4 bladder cancer cells (2016, Homo sapiens)
• Carcinogenic mechanisms from normal to stage 1 bladder cancer cells (a), and from stage 1 to stage 4 bladder cancer cells (b) (2016, Homo sapiens)
• Circadian-disruption-induced gene expression changes in rodent mammary tissues (2016, NA)
• Proposed model of signaling pathway in KC cornea that leads to keratocyte apoptosis during KC (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,Vesicular stomatitis virus,Galaxias sp. southern)
• Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo (2016, NA)
• Overlapping canonical pathways map representing shared biology among the identified candidate genes.Notes: Connected canonical pathways share one or more genes in common (2016, NA)
• Gene–gene networks generated by pathway analysis.Notes: The networks were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA®, QIAGEN Redwood City, www.qiagen.com/ingenuity) (2016, NA)
• Wnt/Beta-catenin canonical pathway (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Helicobacter pylori,Lareunionomyces loeiensis)
• Wnt cross talk (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Helicobacter pylori,Lareunionomyces loeiensis)
• General role of the proteins used for in silico experiments (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Helicobacter pylori,Lareunionomyces loeiensis)
• Signaling pathways involving the molecules reviewed (2016, NA)
• Signaling cascades through Twist and their roles in carcinogenesis (2016, NA)
• YAP Induces High-Grade Serous Carcinoma in Fallopian Tube Secretory Epithelial Cells (2016, Mus musculus,Cricetus cricetus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Diagrams showing the MET signaling pathway (A) and aberrant oncogenic signaling as a result of MET exon 14 skipping deletion (B) (2016, NA)
• Strategies of Brucella to evade the innate and adaptive immunity (2016, Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Brucella abortus,Caulobacter vibrioides,Brucella melitensis,Brucella suis,Brucella abortus 2308,Brucella ovis,Brucella suis 1330,Brucella neotomae,Brucella inopinata BO1,Bos taurus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Babesia microti,Babesia canis,Babesia canis rossi,Mus musculus,Microtus arvalis,Homo sapiens,Human papillomavirus type 16)
• Stealth strategies of Brucella (2016, Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Brucella abortus,Caulobacter vibrioides,Brucella melitensis,Brucella suis,Brucella abortus 2308,Brucella ovis,Brucella suis 1330,Brucella neotomae,Brucella inopinata BO1,Bos taurus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Babesia microti,Babesia canis,Babesia canis rossi,Mus musculus,Microtus arvalis,Homo sapiens,Human papillomavirus type 16)
• Impairment insulin signaling in endothelial hyperglycemic environment (2016, NA)
• Crosstalk between the TLR signaling pathway and the Notch pathway (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Human gammaherpesvirus 4,H1N1 subtype,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Schistosoma mansoni,Homo sapiens)
• Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice (2016, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Capra hircus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Minnesota,herbal medicine,Glycyrrhiza uralensis,Homo sapiens,Mus musculus)
• NPR2 and cGMP signaling pathway enriched in patients with OSA of the discovery cohort (2016, Homo sapiens)
• Select Biological Pathways Significantly Associated with Differentially Regulated Genes (2016, NA)
• Transcriptome and metabolic flux analyses in the central carbon metabolism in ST687 and ST1 (non-producer) strains (2016, NA)
• Schematic view of B3 integrin–GSK3B and BMP-2–Smad cooperation (2016, NA)
• Inhibition of guanylate biosynthesis enzymes limits tumor invasion and growth (2016, NA)
• Recursive partitioning analyses based on tumor location (2016, NA)
• Formation of estrogens, catechol estrogen metabolic pathway and DNA adducts of estrogens (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Mesocricetus auratus,Armoracia rusticana,Arachis hypogaea,Homo sapiens)
• APAP-sensitive proteins related to protein synthesis (2016, NA)
• Proposed store-operated signaling mechanisms in end-feet of Müller glia (2016, NA)
• PPAR signaling pathway (2016, NA)
• Functions of the Ac/N-end rule pathway (2016, NA)
• Network of type I interferon response- and UPR-related genes (2016, NA)
• Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia (2016, NA)
• Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis (2016, Escherichia coli,Staphylococcus aureus,Escherichia coli IS5,Homo sapiens,Mus musculus,Bikinia letestui)
• KEGG pathway analysis., The integrated pathway showing the interactions of differentially expressed proteins in apoptotic and survival pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Epinephelus coioides,Acanthamoeba polyphaga mimivirus)
• De Novo Transcriptome Analysis Provides Insights into Immune Related Genes and the RIG-I-Like Receptor Signaling Pathway in the Freshwater Planarian (Dugesia japonica) (2016, Dugesia japonica,Drosophila melanogaster,Caenorhabditis elegans,Schistosoma mansoni,Crassostrea gigas,Ciona intestinalis,Branchiostoma lanceolatum,Penaeus vannamei,Patinopecten sp.,Clonorchis sinensis,Amphimedon queenslandica,Schmidtea mediterranea,Azumapecten farreri,Saccoglossus kowalevskii,Pediculus humanus corporis,Penaeus chinensis,Oikopleura dioica,Girardia tigrina,Pacifastacus leniusculus,Solen grandis,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Bacillus subtilis,Bacillus subtilis At2,Legionella pneumophila,Vibrio anguillarum,Vibrio alginolyticus,Sugarcane Ramu stunt disease phytoplasma,Danio rerio,Meleagris gallopavo,Oncorhynchus mykiss,Cyprinus carpio,Epinephelus coioides,Homo sapiens,Mus musculus,Oryza sativa Japonica Group,Ostreid herpesvirus 1,NA)
• Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I (2016, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Felis catus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case (2016, NA)
• Classes of drugs that modulate the cGMP-PKG pathway within the cardiomyocyte (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Exercise-induced autophagy signaling (2016, NA)
• Store-dependent and -independent Ca2+ entry pathways in smooth muscle (2016, NA)
• Postulated mechanism of PDGF-C-mediated liver fibrosis and tumor in Smad3-dependent and -independent signaling pathways (2016, NA)
• Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade (2016, Vipera berus berus,Calloselasma rhodostoma,Skiffia francesae,Porphyromonas gingivalis,Borreliella burgdorferi,Homo sapiens,Mus musculus,Bos taurus)
• Identification of Potential Drug Targets in Cancer Signaling Pathways using Stochastic Logical Models (2016, NA)
• ML-hGRN for putative pluripotency renewal pathway in human embryonic stem cells (2016, NA)
• GeneGO pathway map “Development_TGF-beta-dependent induction of EMT via SMADs” is significantly enriched for genes differentially expressed between MCF-7-Snail and MCF-7-Control cells (2016, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Wnt signalling in energy balance regulation (2016, Mus musculus,Rattus norvegicus,Cricetus cricetus,Phodopus sungorus,Microtus arvalis,Phodopus campbelli,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Ovis aries,Mouse mammary tumor virus)
• Transcript Profile of a Traditional Chinese Medicine, Atractylodes lancea, Revealing Its Sesquiterpenoid Biosynthesis of the Major Active Components (2016, NA)
• Apt functions as a feedback inhibitor of the JAK/STAT pathway in CySCs (2016, NA)
• Microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia (2016, Homo sapiens)
• Simplified representation of the PI3K-AKT-mTOR pathway in pancreatic neuroendocrine tumours (2016, Homo sapiens,Mus musculus,Bos taurus,Carex media)
• Canonical or classical NFKB pathway (2016, NA)
• Non-canonical or alternative NFKB pathway (2016, NA)
• Schematic model of the HOG pathway proteins that are involved in the HKR1 subbranch (shown in lavender) (2016, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• FAF1 action on the innate-immunity signaling pathway (2016, NA)
• Model depicting the proposed effect of starvation on microRNA in cancer cells (2016, NA)
• miTALOS v2: Analyzing Tissue Specific microRNA Function (2016, Homo sapiens,Mus musculus,synthetic gene)
• BRAF (V600E) mediates immune suppression and evasion through multiple mechanisms in melanoma (2016, NA)
• Mechanisms and immunotherapeutic targets for glioblastoma (GBM) (2016, NA)
• PI3K/AKT/mTOR signaling pathways (2016, NA)
• The mTOR pathway, it's classical upstream inputs and downstream targets.mTOR exists as two separate signalling complexes which are structurally distinct (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Mechanism of DQP efficacy on CHD rats (2016, Saccharomyces cerevisiae,Oryza sativa,Candida dubliniensis,Salvia miltiorrhiza,Panax notoginseng,Homo sapiens,Rattus norvegicus)
• Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4 (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans)
• Ras MAP kinase pathway (2016, NA)
• Metabolic flux profiling of MDCK cells during growth and canine adenovirus vector production (2016, unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Human adenovirus 5,Human adenovirus sp.,Canine mastadenovirus A,Canine adenovirus 2,Canine adenovirus 2 strain Toronto A 26-61,Bos taurus,Canis lupus familiaris,Homo sapiens,Matthiola incana)
• Brain-derived neurotrophic factor signaling pathway (2016, Rattus norvegicus,Homo sapiens)
• Signal transduction that epithelium sodium channels involved in (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Xenopus laevis)
• Death receptor signaling in SIVA (2016, NA)
• GNAQ (encodes for GAq) signaling via RAS/ERK pathway (2016, Homo sapiens)
• ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size (2016, NA)
• Schematic illustration of GSK3B/eIF2BE and mTORC1 signaling in AKT-induced CNS axon regeneration (2016, NA)
• GPCRs mediated signaling pathways (2016, Mus musculus,Rattus norvegicus,Meleagris gallopavo,Arripis georgianus,Homo sapiens,Bos taurus,Human immunodeficiency virus)
• Interaction between GPCR and BACE1 in neuronal cell (2016, Mus musculus,Rattus norvegicus,Meleagris gallopavo,Arripis georgianus,Homo sapiens,Bos taurus,Human immunodeficiency virus)
• Proposed model through which chronic stress and glucocorticoids (GCs) may contribute to Alzheimer disease (AD) pathology (2016, NA)
• Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway (2016, NA)
• Negative regulatory network inhibits the DLK-1 pathway in C (2016, NA)
• A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer (2016, NA)
• Regulation of SMN2 gene expression in SMA (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Eucalyptus intertexta)
• ILC3s in the context of cancer (2016, Homo sapiens)
• Molecular mechanisms that mediate neurodegeneration in SMA (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Eucalyptus intertexta)
• MicroRNA-17-5p-activated Wnt/Beta-catenin pathway contributes to the progression of liver fibrosis (2016, NA)
• Prostate cancer stem cells: the role of androgen and estrogen receptors (2016, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC (2016, NA)
• Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism (2016, NA)
• Thyroid hormone-signaling pathway (2016, Homo sapiens,Mus musculus)
• Kinetic models describing the in vivo metabolism of the HDL apolipoproteins on each HDL size fraction (2016, Homo sapiens)
• ATM, ATR and DNA-PK signalling pathways (2016, NA)
• Oxidative stress under ambient and physiological oxygen tension in tissue culture (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular mechanisms by corilagin suppresses cholangiocarcinoma progression through Notch signaling pathway (2016, NA)
• Reelin signaling pathway in adult synaptic plasticity (2016, NA)
• The signaling network of JAK/STATs in IBD (2016, NA)
• Kinase signaling pathways involved in T cell receptor activation (2016, Homo sapiens,Mus musculus)
• ARE- and GRE-signaling pathways stimulated through growth factors and growth hormones (2016, Homo sapiens,Mus musculus)
• Effects of virus mediated targeting of PDZ proteins often converge on the PI3K/AKT signal transduction pathway (2016, NA)
• 3Cpro from different picornaviruses suppress the immune response (2016, Enterovirus C,Coxsackievirus B3,Enterovirus A71,Encephalomyocarditis virus,Coxsackievirus,Foot-and-mouth disease virus,Human rhinovirus sp.,enterovirus D68,Echovirus,Poliovirus 2,rhinovirus A2,Poliovirus 3,Aichivirus A,rhinovirus B3,rhinovirus B14,Human hepatitis A virus,Porcine sapelovirus 1,Coxsackievirus A24,Homo sapiens,Mus musculus,vectors,NA)
• EGFR- and ALK-signaling pathways and their respective inhibitors (2016, Diaporthe sclerotioides,Aegilops tauschii,Homo sapiens,Rattus norvegicus,Turdus migratorius)
• Inhibition of innate immunity by arenavirus NP and Z (2016, Homo sapiens,Ebola virus,NA)
• Selective upregulation of Mcl-1 and HSP27 during HCMV infection of monocytes (2016, Homo sapiens,Human betaherpesvirus 5)
• OAS-RNase L pathway (2016, NA)
• Proposed scheme for the protective effects of linagliptin against ABeta-induced neuronal insulin signaling blockade.GLP-1 is synthesized and secreted by neuronal cells (2016, NA)
• Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes (2016, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Involvement of ROS in normal stem cell quiescence and self-renewal (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? (2016, NA)
• Canonical Wnt signalling pathway implicated in diabetic nephropathy (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• Anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through AvB3 integrin interaction (2016, NA)
• NF-Y activates genes of metabolic pathways altered in cancer cells (2016, NA)
• SLE risk haplotype upregulates the antigen presentation pathway (APP) (2016, NA)
• Transfer of parasitic extracellular vesicle cargo to host cells (2016, Trypanosoma cruzi,Leishmania donovani,Homo sapiens)
• Proposed model for the role of the Wnt/Beta-catenin pathway during odontogenesis (2016, NA)
• Latency-associated nuclear antigen-mediated deregulation of cell cycle (2016, NA)
• Most correlated signaling pathway was the rheumatoid arthritis pathway (http://www.kegg.jp/kegg-bin/show_pathway?map05323) (2016, Mus musculus,Homo sapiens)
• Signaling pathway and biological function of Rap2B, a Ras family small guanosine 5′-triphosphate-binding protein (2016, NA)
• Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children (2016, Homo sapiens,Mus musculus,Nicotiana tabacum)
• PI3K/AKT signaling pathway (2016, Homo sapiens)
• Rho/ROCK signaling pathway (2016, NA)
• Crosstalk between Autophagy and Apoptosis (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Sus scrofa,Human alphaherpesvirus 1)
• Relevant intracellular signal transduction pathways of local anesthetic-induced toxicity (2016, NA)
• Argininosuccinate synthetase (ASS)-negative cell death induced by arginine deprivation (2016, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Staphylococcus epidermidis,Bacillus licheniformis,Bacillus subtilis subsp. subtilis,Streptococcus gordonii,Streptococcus suis,Latilactobacillus sakei,Mycoplasmopsis arginini,Streptococcus ratti,Streptococcus pyogenes str. Manfredo,Laribacter hongkongensis,Diaporthe sclerotioides,Candida albicans,clinical samples,uncultured beta proteobacterium,Homo sapiens,Mus musculus,Trypanosoma cruzi)
• Pathways that represent potential targets for miRNAs in drug-resistant GC (2016, Homo sapiens,Mus musculus,Helicobacter pylori,unidentified,Erinaceus europaeus,NA)
• Cross-regulatory pathways between focal adhesions and cadherins (2016, NA)
• NRAS mutant melanoma: an overview for the clinician for melanoma management (2016, Homo sapiens)
• Influence of TGFB‐SMAD and TGFB‐TAK1 signalling on adrenoceptor‐mediated pathways in LV heart failure progression (2016, NA)
• Summary of NOP receptor signaling (2016, NA)
• Direct and indirect inhibition of MYC (2016, Homo sapiens,Mus musculus)
• A, Established relationships between genes involved in response to hyperosmotic stress and heat shock (2016, Saccharomyces cerevisiae,Homo sapiens)
• Proposed model for NP signaling (2016, NA)
• To ensure successful invasion of the host cell T (2016, NA)
• Mechanisms of NaCl stress mitigation by application of exogenous NO (2016, NA)
• Autism spectrum disorders (ASD) candidate genes cluster into functional networks, and the two most prominent are synapse structure/function and protein translational control (2016, NA)
• A proposed model for chloroplast retrograde regulation of heat stress responses (2016, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,PX clade,Spinacia oleracea,Chlamydomonas reinhardtii,Pisum sativum,Physcomitrium patens,Chara corallina,Homo sapiens,Escherichia coli,NA)
• cAMP as a regulator of immunity (2016, NA)
• CAMP pathway in Treg and its regulation by IFNA (2016, NA)
• Polyamine metabolic pathway (2016, Nicotiana tabacum,Homo sapiens)
• Transcriptome analysis in different rice cultivars provides novel insights into desiccation and salinity stress responses (2016, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Gossypium hirsutum,Cicer arietinum,Pyricularia oryzae,Oryza sativa Indica Group,Cucurbita maxima,Cucurbita moschata,Gossypium herbaceum,Populus simonii,Oryza coarctata,Homo sapiens,Weizmannia coagulans)
• Insulin resistance in the fetus from gestational diabetes mellitus (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Triportheus paranensis)
• Identified signaling pathways downstream to glycine in NSCs (2016, NA)
• Hypothesized signaling pathway of DR6-mediated tumor angiogenesis (2016, Bos taurus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Gallus gallus,Raphanus sativus)
• Visualization of all differentially expressed proteins mapped to the TCA cycle pathway in the development of RAW 264.7 cells into osteoclasts in low serum culture system (2016, NA)
• Schematic diagram illustrating synthesis of ET peptides and interaction with receptors (2016, Homo sapiens,Mus musculus)
• Adiponectin signal transduction pathway implicating a crosstalk with the insulin signaling pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Mitochondria-mediated intrinsic (a) and death receptor-mediated extrinsic (b) pathway (2016, NA)
• Notch 1 signaling pathway and proposed mechanism of action of CJ (2016, NA)
• TP53 pathway in CLL (2016, NA)
• Targeting of BCR and PI3K/AKT signaling as therapeutic strategy in CLL (2016, Homo sapiens,Mus musculus)
• Quantitative Modeling of the Alternative Pathway of the Complement System (2016, Homo sapiens,Escherichia coli,Cricetulus griseus)
• In plexiform neurofibromas and MPNSTs, neurofibromin loss deregulates multiple proteins from both the classic Ras and R-Ras subfamilies (2016, Homo sapiens,Mus musculus,transposons)
• Regulation of neural precursor plasticity within the classical neurogenic zones (2016, NA)
• Role of histone PTMs in DNA damage repair (2016, NA)
• Frequently mutated genes in ErbB signaling pathway (2016, NA)
• Transcriptome sequencing reveals e-cigarette vapor and mainstream-smoke from tobacco cigarettes activate different gene expression profiles in human bronchial epithelial cells (2016, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders (2016, NA)
• Signaling cascades of Cripto-1, Notch/CSL, and Wnt/Beta-catenin (2016, NA)
• MYC: regulator of post‐transcriptional mechanisms (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Human papillomavirus type 16)
• Association of MicroRNA-196a2 Variant with Response to Short-Acting B2-Agonist in COPD: An Egyptian Pilot Study (2016, NA)
• Schema for potential state of canonical Wnt signaling pathway in mouse models (2016, NA)
• Trace amine-associated receptor 1 (TAAR1), a TA- and amphetamine-activated GPCR, at a DA synapse (2016, NA)
• Schematic action model of rutaecarpine which exert caloric restrict acting on cell metabolism at multiple levels and reduce energy-consuming processes in vivo and in vitro (2016, NA)
• Altered signaling for endothelin-1 (ET-1) and nitric oxide (NO) in endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) in pulmonary hypertension (2016, NA)
• Possible mechanism for endothelial–smooth muscle cross-talk via the myoendothelial junctions (MEJs) in pulmonary hypertension exemplified by serotonin actions (2016, NA)
• Proposed model of the mTOR/TGF‐B1 pathway in the regulation of ceramide synthesis (2016, Saccharomyces cerevisiae,Armoracia rusticana,Zea mays,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• EGFR and IGF1R signaling pathways.Notes: Binding of extracellular ligands results in autophosphorylation of key tyrosine residues in the C-terminal domain of EGFR, which allows downstream proteins to bind through their Src homology 2 (SH2) domains (2016, NA)
• GUIdock: Using Docker Containers with a Common Graphics User Interface to Address the Reproducibility of Research (2016, Homo sapiens,Saccharomyces cerevisiae,Panthera leo)
• BCR signaling pathway is the top-ranked network with increasing association with HuR in response to NS3/4A overexpression (2016, NA)
• Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGFB signalling pathways (2016, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Lareunionomyces loeiensis,vectors)
• Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer (2016, Homo sapiens,Saccharomyces cerevisiae,clinical samples)
• Main signaling pathways of PRRs (2016, NA)
• Ubiquitin regulation of TLR signaling (2016, NA)
• Glucose promotes tumor growth by activating lipid synthesis and uptake upon N-glycosylation of SCAP (2016, NA)
• Molecular mechanisms involved in autophagy and NAFLD.Notes: 1 (2016, NA)
• Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis (2016, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis variant bovis BCG str. Sweden,Homo sapiens,Macaca fascicularis,Mus musculus,Sequoia sempervirens,Trypanosoma cruzi)
• In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment (2016, Human papillomavirus,Human papillomavirus type 16,human papillomavirus 18,Homo sapiens,Mus musculus,Eptesicus serotinus)
• In silico pathway analysis in cervical carcinoma reveals potential new targets for treatment (2016, Human papillomavirus,Human papillomavirus type 16,human papillomavirus 18,Homo sapiens,Mus musculus,Eptesicus serotinus)
• Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation (2016, NA)
• Novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells (2016, NA)
• Molecular signaling partners of ROCK1 (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Armoracia rusticana,Equus caballus,Raphanus sativus,Homo sapiens,Drosophila melanogaster)
• TSH action (2016, NA)
• MicroRNAs downregulated in OSCC target multiple genes in the PI3K/AKT pathway (2016, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Mesocricetus auratus,Iris germanica,Homo sapiens)
• MicroRNAs upregulated in OSCC repress multiple genes in the p53 signaling pathway (2016, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Mesocricetus auratus,Iris germanica,Homo sapiens)
• Schematic overview of necroptotic pathway (2016, NA)
• NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells (2016, NA)
• Schematic depicting the role of Nupr1–Chop/P53–PUMA/Beclin1 signaling pathway in METH-induced endothelial cell apoptosis (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Interaction between the genes differentially expressed in response to HDM (2016, NA)
• Signaling Pathway of Rho Guanine Nucleotide Exchange FactorImportant functions of this pathway involve antiapoptotic actions and regulation of actin-myosin interaction (2016, Mus musculus,Rattus norvegicus,Gallus gallus,Calloplesiops altivelis,Homo sapiens,Saccharomyces cerevisiae,NA)
• NRAS mutant skin cell lines mutations in the TLR3 Cascade pathway (2016, Homo sapiens,Mus musculus)
• Hypothetical gastrin-cholecystokinin B receptor (CCKBR) signal transduction pathway (2016, NA)
• Smad and non-Smad transforming growth factorB1 (TGFB1) signaling pathways (2016, Homo sapiens)
• Translocator Protein-Mediated Stabilization of Mitochondrial Architecture during Inflammation Stress in Colonic Cells (2016, Saccharomyces cerevisiae,Armoracia rusticana,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Venustaconcha ellipsiformis)
• Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta,Phleum pratense)
• Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta,Phleum pratense)
• Neuroenergetics of traumatic brain injury (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Network analysis (2016, NA)
• The regulation of MCT1 by the canonical Wnt/Beta-catenin pathway in RBE4 cells (2016, Rattus norvegicus,Homo sapiens)
• Proposed model for cross-talk of IGF1 and integrin signaling (2016, NA)
• Ingenuity pathway analysis identifies two highly enriched networks for the Tau-interacting proteins (2016, Armoracia rusticana,Sequoia sempervirens,Agriosomyces longus,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Drosophila melanogaster)
• Coordinating muscle-specific gene expression with cell cycle exit (2016, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae)
• Core level regulatory network of osteoblast as molecular mechanism for osteoporosis and treatment (2016, Saccharomyces cerevisiae,Arabidopsis thaliana,Iris germanica,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• The role of the oncofetal H19 lncRNA in tumor metastasis (2016, NA)
• DAB2IP in cancer (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Campylobacter jejuni)
• Pathways of DNA demethylation mediated by TET enzymes (2016, NA)
• Targeting of the Wnt/Beta-catenin signaling pathway by Tat altered miRNAs (2016, NA)
• Targeting of the axonal guidance signaling by Tat altered miRNA (2016, NA)
• Canonical Wnt signaling pathway (Beta-catenin-dependent Wnt signaling pathway) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Equus caballus,Mouse mammary tumor virus,clinical samples)
• Noncanonical Wnt signaling pathway (Beta-catenin-independent Wnt signaling pathway) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Equus caballus,Mouse mammary tumor virus,clinical samples)
• Immune signaling in C (2016, Brugia malayi,Homo sapiens)
• Planar cell polarity (PCP) pathway regulates epithelial cell and tissue polarity by regulating the actin cytoskeleton (2016, Homo sapiens)
• Activation of the Wnt/Ca2+pathway triggers the release of intracellular calcium stores (2016, Homo sapiens)
• Drugs interfering with breast cancer (BC)- and obesity-related pathways (2016, NA)
• Complement activation pathways (2016, Homo sapiens)
• Transcriptome Variability in Keratocystic Odontogenic Tumor Suggests Distinct Molecular Subtypes (2016, Homo sapiens,Human immunodeficiency virus 1)
• Figure demonstrates the wide array of interactions present in the Wnt signaling cascade (2016, NA)
• Role of the nNOS/peroxynitrite/AMPK vicious cycle in stroke.Stroke causes necrotic neuronal cell death in the core area immediately after the injury (2016, NA)
• MET signaling pathway (2016, Homo sapiens,Mus musculus)
• Sex Difference of Egfr Expression and Molecular Pathway in the Liver: Impact on Drug Design and Cancer Treatments? (2016, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Genes positively and negatively connected to the expression of Egfr in the mouse liver (2016, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Representation of the cross talk among different pathways under water-deficit conditions (2016, NA)
• Simplified model of ABA signaling in guard cells (2016, NA)
• Notch canonical and non-canonical signaling (2016, NA)
• Hypothetical model summarizing the potential signaling pathway of nitric oxide (NO) involved in cold-inhibited C (2016, NA)
• Proteins encoded by genes analyzed in this study in the inhibition of the Wnt signaling (2016, NA)
• Schematic model illustrating O‐GlcNAc pathway and influence of glucose and O‐GlcNAcylation on chondrogenic differentiation (2016, NA)
• CCL20 production and function in human non‐small cell lung cancer (2016, NA)
• Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Enterovirus C)
• Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF (2016, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Siproeta stelenes,Renilla reniformis,Homo sapiens)
• Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media (2016, Armoracia rusticana,Sequoia sempervirens,Candida albicans 23P,Candida albicans 25P,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Chinchilla chinchilla,Staphylococcus aureus,Haemophilus influenzae,Homo sapiens,NA)
• Computational Reconstruction of NFKB Pathway Interaction Mechanisms during Prostate Cancer (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Nicotiana tabacum,Epinnula magistralis,NA)
• Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Solanum lycopersicum,Helianthus annuus,Homo sapiens)
• Genome-wide gene expression analysis for S49 (Neo) and S49 (OS 4–25) cells (2016, NA)
• Necroptotic pathway (2016, Homo sapiens,Mus musculus,Brucella abortus,NA)
• Hepatic glycolysis, fructolysis and triglyceride synthesis (2016, NA)
• Regulation of de novo lipogenesis by SREBP1c and ChREBP (2016, NA)
• Cellular iron homeostasis and putative involvement of NBIA‐associated genes (2016, NA)
• Inflammation in gastric cancer: Interplay of the COX‐2/prostaglandin E2 and Toll‐like receptor/MyD88 pathways (2016, Homo sapiens,Mus musculus,Helicobacter pylori,NA)
• Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGFB Signaling Pathway (2016, NA)
• Nurr1 pathway and Nurr1‐based therapies for Parkinson's disease (2016, Mus musculus,Rattus norvegicus,Adenoviridae,Ginkgo biloba,adeno-associated virus 2,Toxicodendron vernicifluum,Homo sapiens)
• Different molecules involved in the mTOR activation cascade (2016, Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus,Euphilotes enoptes,mixed subtypes)
• Cancer-relevant pathway map (2016, NA)
• Domain architectures of RIG-I/MDA5 and MAVS (2016, NA)
• Molecular pathways and targets of the epithelial–mesenchymal transition (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Triportheus paranensis)
• Hexosamine biosynthetic pathway (HBP) and glycosylated EMT targets (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Triportheus paranensis)
• microRNA let-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells by linking JNK1/2 to AP-1/STAT1/STAT3 signaling (2016, NA)
• Calorie restriction as an intervention in ageing (2016, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Saccharomyces cerevisiae,Canis lupus familiaris,Dipnomorpha)
• Plausible biosynthetic pathway leading to atisine in A (2016, Nicotiana tabacum,Oryza sativa,Glycine max,Stevia rebaudiana,Picea glauca,Aconitum heterophyllum,Spiraea japonica,Dipturus trachyderma,Homo sapiens)
• Control of the FA pathway by SUMO and SUMO-like modifications (2016, NA)
• Signaling through EGFR (2016, NA)
• An integrated model of the TLR signaling pathway modulated by the multifurcating motif of poeModules M14-M18 (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns (2016, Dromiciops gliroides,Homo sapiens)
• Hibernating South American marsupial, Dromiciops gliroides, displays torpor-sensitive microRNA expression patterns (2016, Dromiciops gliroides,Homo sapiens)
• The RANK/RANKL/OPG pathway as a common regulator of bone and muscle cells (2016, NA)
• Ca2+-mediated regulation of autophagy in the heart (2016, NA)
• ER stress and autophagy in AD (2016, NA)
• Autophagy pathway and its interaction with HSV-1 (2016, NA)
• Graphic representation of apoptosis signalling pathways (2016, NA)
• Graphic representation of apoptosis and viral replication (2016, NA)
• The butanone biosynthetic pathway (2016, NA)
• Morphogens involved in BBB development and integrity influence signaling of common pathways (2016, NA)
• Differences in Whole Blood Gene Expression Associated with Infection Time-Course and Extent of Fetal Mortality in a Reproductive Model of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection (2016, NA)
• Transcriptional Profiling of Ileocecal Valve of Holstein Dairy Cows Infected with Mycobacterium avium subsp. Paratuberculosis (2016, Mycobacterium avium,Homo sapiens)
• Involvement of ROS in regulating M1 responsible phagocytic activity and inflammatory response (2016, NA)
• Drug target identification using network analysis in Sini decoction (2016, Zingiber officinale,Glycyrrhiza uralensis,Corydalis yanhusuo,Aconitum carmichaelii,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Tritrichomonas suis)
• Meso-2,3-BD biosynthetic pathway in B (2016, Bacillus subtilis,Homo sapiens)
• Scheme representing the functions of ASCs after LL-37 treatment (2016, NA)
• Synaptic transmission: lipid-protein interactions (2016, NA)
• Illustration of the complexity of the balance between A2A–D2R heteroreceptor and homoreceptor complexes in key brain regions for schizophrenia such as the nucleus accumbens (2016, NA)
• Second messenger signaling pathways (2016, NA)
• Five significant subnetworks of the N-group, associated with (A) glutathione metabolism (B) leucine and isoleucine metabolism (C) pancreatic cancer (D) calcium signaling pathway and (E) the mitogen-activated protein kinase pathway (2016, NA)
• Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells (2016, NA)
• Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic (2016, NA)
• (T)cell-inflamed and non-(T)cell-inflamed phenotypes (2016, Homo sapiens,Mus musculus)
• Schematic overview of de novo and salvage dNTP biosynthetic pathways and the mechanism of action of dCK-dependent nucleoside analog prodrugs (2016, NA)
• 1,25(OH)2D3-induced signaling pathways involved in the regulation of cell proliferation, apoptosis, and inflammation in cancer (2016, Homo sapiens,Mus musculus)
• A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer (2016, Homo sapiens,Mus musculus,clinical samples)
• Insulin signaling pathway (2016, NA)
• Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice (2016, NA)
• Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice (2016, NA)
• Infant birth weight and third trimester maternal plasma markers of vascular integrity: the MIREC study (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Thyreodon group)
• Changes to coral health and metabolic activity under oxygen deprivation (2016, NA)
• Diagrammatic representation of the effect of tempol on the oxidative stress-mediated the changes of PI3K/Akt/Nrf2 and apoptotic signaling in renal I/R injury (2016, NA)
• Main molecular mechanisms affected in malignant megakaryopoiesis and platelet function defects (2016, NA)
• TGFB signaling pathway and related miRNAs (2016, Hepatitis B virus,Human gammaherpesvirus 8,Francisella tularensis,Francisella tularensis subsp. novicida,Homo sapiens,Mus musculus)
• Id2 network model in insulin signaling, thermogenesis, and adipogenesis pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Factors contributing to the acquisition of the hallmarks of cancer in a solid tumour cell (2016, NA)
• TGFB signaling pathway mediates KLF17 expression (2016, NA)
• HSP receptors (2016, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• Signalling and muscle proteins synthesis (MPS) responses induced by amino acids (AAs) and different contraction intensities (2016, NA)
• Phytotoxins and microbial effectors targeting the JA signaling components (2016, NA)
• Under normal conditions, the secreted by mitochondria is transformed by catalase action and GSH into H2O (2016, Human betaherpesvirus 5,Measles morbillivirus,Betapolyomavirus macacae,Betapolyomavirus hominis,JC polyomavirus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Dipturus trachyderma)
• Pathogens-induced TLR signaling cascade in innate immune cells may exacerbate autoimmune diseases (2016, NA)
• YAP promotes cancer cell survival and resistance to RAF-MEK-targeting agents (2016, Homo sapiens)
• Dormancy programs and their potential use in patient treatment (2016, NA)
• Inflammasome activation and purinergic signaling in Chlamydia-infected cells (2016, NA)
• Influence of cellular context on the outcome of E2F depletion (2016, Mus musculus,Homo sapiens)
• Possible model to explain the involvement of AATF in mTOR pathway (2016, NA)
• Differential signaling pathway of EP4 (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Sus scrofa,Helicobacter pylori)
• Simplified scheme of the EP4 signaling in PGE2-mediated hypertrophic actions (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Sus scrofa,Helicobacter pylori)
• Resistance mechanisms in MAPK-inhibitor treated melanoma (2016, Danio rerio,Pollachius virens,Homo sapiens,Mus musculus)
• MST2-RASSF protein–protein interactions through SARAH domains (2016, Homo sapiens)
• Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli)
• ErbB4 signal pathway (2016, NA)
• Sphingolipid biosynthetic pathway (2016, Saccharomyces cerevisiae,Homo sapiens)
• Postsynaptic regulation of the SUMO pathway (2016, NA)
• MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells (2016, NA)
• KEGG pathway analysis for the Toll like receptor (TLR) signaling pathway differentially expressed genes (DEGs) expressed in response to SAV-3 infection in TO-cells (2016, ssRNA viruses,dsRNA viruses,Infectious pancreatic necrosis virus,Isavirus salaris,Salmonid alphavirus subtype 3,Salmon pancreas disease virus,Danio rerio,Oncorhynchus mykiss,teleost fish,Salmo salar,Homo sapiens,Bos taurus,Drosophila melanogaster,prion,Salvia miltiorrhiza)
• Summary of the Toll like receptors (TLR) and RIG-I like receptor (RLR) pathway genes based on upregulated genes shown in and excluding the downregulated genes shown in and (2016, ssRNA viruses,dsRNA viruses,Infectious pancreatic necrosis virus,Isavirus salaris,Salmonid alphavirus subtype 3,Salmon pancreas disease virus,Danio rerio,Oncorhynchus mykiss,teleost fish,Salmo salar,Homo sapiens,Bos taurus,Drosophila melanogaster,prion,Salvia miltiorrhiza)
• KEGG pathway analysis of the RIG-I-like receptor DEGs expressed in response to SAV-3 infection TO-cells (2016, ssRNA viruses,dsRNA viruses,Infectious pancreatic necrosis virus,Isavirus salaris,Salmonid alphavirus subtype 3,Salmon pancreas disease virus,Danio rerio,Oncorhynchus mykiss,teleost fish,Salmo salar,Homo sapiens,Bos taurus,Drosophila melanogaster,prion,Salvia miltiorrhiza)
• NF-kB signal transduction pathway (2016, Glycine max,Lareunionomyces loeiensis,Camellia sinensis,Scutellaria baicalensis,Citrus x paradisi,Fagopyrum esculentum,Glycyrrhiza glabra,Nelumbo nucifera,Perilla frutescens,Hibiscus sabdariffa,Fagopyrum tataricum,Ruta graveolens,Alpinia conchigera,Picea crassifolia,Dysosma delavayi,Mus musculus,Rattus norvegicus,Cavia porcellus,Salmonella enterica subsp. enterica serovar Typhimurium,Lacticaseibacillus rhamnosus,Homo sapiens,NA)
• MAP Kinase pathway (2016, Glycine max,Lareunionomyces loeiensis,Camellia sinensis,Scutellaria baicalensis,Citrus x paradisi,Fagopyrum esculentum,Glycyrrhiza glabra,Nelumbo nucifera,Perilla frutescens,Hibiscus sabdariffa,Fagopyrum tataricum,Ruta graveolens,Alpinia conchigera,Picea crassifolia,Dysosma delavayi,Mus musculus,Rattus norvegicus,Cavia porcellus,Salmonella enterica subsp. enterica serovar Typhimurium,Lacticaseibacillus rhamnosus,Homo sapiens,NA)
• Regulation of lipid metabolism by BAF60a and BAF60c in periportal and perivenous hepatocytes, respectively, under the control of nutritional and hormonal signals (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Potential molecular pathways and targets mediating the proliferative response to the MF, as from the present and previously published data (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetus cricetus,Homo sapiens,Armoracia rusticana)
• Matrix Hyaluronan Promotes Specific MicroRNA Upregulation Leading to Drug Resistance and Tumor Progression (2016, NA)
• Regulation of RNase 7 induction (2016, Staphylococcus aureus,Staphylococcus epidermidis,Trichophyton rubrum,Homo sapiens)
• BBR-induced PAI-1 cell signaling pathway in HCC cells (2016, Coptis chinensis,Rheum palmatum,Coptis teeta,Hypholoma sublateritium,Homo sapiens,Capra hircus,Meleagris gallopavo)
• Aberrations in the Ras signaling pathway that lead to excessive proliferation (2016, Homo sapiens)
• Schematic diagram illustrates the role of matrilin-3 in ECM modulation of cartilage (2016, Homo sapiens,Mus musculus,Gallus gallus)
• HepatoDyn: A Dynamic Model of Hepatocyte Metabolism That Integrates 13C Isotopomer Data (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson’s Disease (2016, NA)
• Reactions induced by IL-10 (2016, NA)
• Tested Wnt-related genes and proteins and their functions in the canonical Wnt signaling pathway are shown here (2016, NA)
• Riboclustering-mediated signaling pathways that regulate innate inflammatory modulators, including cytokines/chemokines (2016, Homo sapiens,Mus musculus,Legionella pneumophila,NA)
• Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions (2016, Gadus morhua,Homo sapiens)
• Different compounds in cigarette smoke regulate EMT (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Molecular Mechanisms of EndoMT (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Recurrent genetic alterations and targeted therapies under investigation in iCCA (2016, NA)
• Action model of the brown planthopper wing polymorphism regulated by the PI3K/Akt/FOXO Signaling pathway (2016, Drosophila melanogaster,Acyrthosiphon pisum,Nilaparvata lugens,Megoura viciae,Gryllus firmus,Homo sapiens,Oryza sativa)
• Insulin resistance and feedback in the Drosophila fat body (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Manduca sexta,Homo sapiens)
• Pathway association between TH and metabolic process via ABCC8 (Kir6.2) (A) (2016, NA)
• A) A simplified schematic of the Wnt signaling pathway (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis)
• Mechanisms contributing to the repression of hepatic gluconeogenesis by Wnt signaling activation (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis)
• Proposed models that potentially link collagen VI myopathy and circadian genes (2016, Homo sapiens,Mus musculus)
• Mechanistic target of rapamycin (mTOR) signaling pathway (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,Heterocephalus glaber,marmosets,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Candida albicans,Canis lupus familiaris,Streptomyces hygroscopicus)
• Appropriate activation and feedback control of TP53 activity is critical to effective tumor suppression (2016, Homo sapiens)
• Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Genes under multiple regulatory controls in the PTEN pathway (2016, NA)
• Negative regulatory NLR functions during viral infection (2016, NA)
• Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis (2016, NA)
• Dynamic angiogenic signaling balance and angiogenic switch (2016, NA)
• Androgen signal pathways (2016, NA)
• Mechanisms of androgens in regulating EC and EPC proliferation (2016, NA)
• Interaction network of innate immunity related proteins (2016, Influenza A virus,unidentified influenza virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza A virus H3N2,Swine influenza virus,H3N3 subtype,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Gallus gallus,Anas platyrhynchos,Homo sapiens,Mus musculus,Armoracia rusticana)
• Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2/SMAD signaling (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Panax ginseng,Dipturus trachyderma)
• Detected regulatory influences on the canonical Wnt pathway (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Mouse mammary tumor virus,Enterovirus C,Homo sapiens,Bos taurus,Xenopus laevis)
• Role of HDACs and associated pathways involved in the processes of autophagy during the progression of DN (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• PKC activation induces TNFA production in cells sensitizing them to SMs (2016, Homo sapiens)
• NFAT signaling pathway (2016, NA)
• Regulation of the apoptosis signaling pathway by NFAT proteins (2016, NA)
• NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes (2016, NA)
• NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes (2016, NA)
• NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes (2016, NA)
• Main pathways involved in CD40-TRAF signaling (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Working model of the regulation of the type I interferon and NFKB signaling pathway by TRIM9s (2016, NA)
• Proposed model depicting the opposing roles of type I and type II NKT cells in inflammatory diseases in the liver (2016, Borreliella burgdorferi,Novosphingobium aromaticivorans,Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Evaluation of energy metabolism and calcium homeostasis in cells affected by Shwachman-Diamond syndrome (2016, NA)
• Role of p38 MAPK in Wnt signaling (2016, NA)
• Inhibition of EMT in NSCLC cells (2016, NA)
• EGF-Ras-ERK signaling promotes duct vs. G1 pore fate (2016, Caenorhabditis elegans,Homo sapiens)
• Recycling and regulation of eIF2 by eIF2B (2016, Saccharomyces cerevisiae,Homo sapiens)
• Overexpressed metabolic pathways in the infection (2016, Staphylococcus aureus,Streptococcus pneumoniae,Staphylococcus aureus LAC,Staphylococcus aureus USA600-BAA1754,Homo sapiens,Mus musculus,Oryctolagus cuniculus,human metagenome,NA)
• Proposed signaling pathway for histamine-induced resetting of the circadian pacemaker in the SCN (2016, NA)
• Distribution of pathway sinks on the SOM map depending on pathway topology (2016, Homo sapiens,PX clade)
• Mechanisms by which HIV protease inhibitors (HPIs) enhance radiosensitivity (2016, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens)
• Analysis of signaling pathways specific to base:apex comparison (2016, NA)
• Current concepts regarding developmental mechanisms in diabetic retinopathy in Taiwan (2016, NA)
• DDX3 is involved in Wnt/Beta-catenin pathway (2016, NA)
• RTKs mediate DDR through canonical AKT and RAS pathways (2016, Homo sapiens)
• Some RTKs regulate DDR through specific canonical pathways (2016, Homo sapiens)
• CE-TOFMS analysis of intracellular metabolites related to nucleotide and to Gly/Ser/Cys metabolic pathway after 24 h of exposure to acidosis: Bar graphs show the relative intracellular amount of metabolites (2016, NA)
• mTOR signaling pathway regulated by CDDO-Me in Ec109 cells (2016, Homo sapiens)
• HSV modulates apoptosis signaling (2016, NA)
• Terpenoid indole alkaloid pathway (2016, NA)
• Protection mechanisms of BPS in diabetic nephropathy (2016, NA)
• 4-(Tert-butyl)-2,6-bis(1-phenylethyl)phenol induces pro-apoptotic activity (2016, herbal medicine,Panax ginseng,Agaricus bisporus,Beauveria bassiana,Ophiocordyceps sinensis,Cordyceps militaris,Cordyceps pruinosa,Homo sapiens,Bos taurus)
• Reelin signaling mechanisms in brain development and function (2016, Homo sapiens,Mus musculus)
• Schematic illustration represents the potential signaling transduction mechanism by which cancer cell-derived exosomes prevent monocyte apoptosis (2016, NA)
• Inositide signaling pathway and target agents used to treat gastric cancer and colorectal cancer (2016, Homo sapiens,Mus musculus)
• Cellular innate response to rotavirus infection (2016, NA)
• Signaling pathways of sarco-KATP and mito-KATP channels in skeletal muscle (2016, NA)
• Simplified schematic of signaling junctions that integrate the recognition of pathogen, host or environmentally derived DAMPs and dAMPs by their cognate receptors (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Oryza sativa,Human immunodeficiency virus 1,Middle East respiratory syndrome-related coronavirus,Homo sapiens,prion,Rutilus frisii)
• Illustration of negative regulators of CaN-NFAT signaling pathway in cardiac hypertrophy (2016, Homo sapiens,Mus musculus,Chlamydia phage 2,NA)
• Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro (2016, NA)
• Punctuated evolution of a conserved regulatory network (2016, NA)
• Reperfusion Injury Salvage Kinase (RISK) and Survivor Activating Factor Enhancement (SAFE) pathway model of ischaemic conditioning (2016, NA)
• Three proposed mechanisms through which inorganic nitrate reduces blood pressure (2016, NA)
• Emerging treatment options for myelofibrosis: focus on pacritinib (2016, NA)
• Birth of a Carcinoma-associated fibroblasts (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Schematic depiction of the signaling pathway underlying PA activity as a chemosensitizer for TOP inhibitors (2016, Homo sapiens,Mus musculus,Camptotheca acuminata)
• Effects of docosahexaenoic acid on muscle protein turnover and lipid mobilization during 48 h fasting (2016, Armoracia rusticana,Triticum aestivum,Helianthus annuus,Carthamus tinctorius,endophyte RAb7,Mus musculus,Rattus norvegicus,Homo sapiens)
• Hypothesis on skeletal muscle adiponectin resistance in chronic heart failure (2016, NA)
• Signaling pathways downstream of Group I mGluR stimulation (2016, NA)
• Interplay between Fanconi anemia and homologous recombination pathways in genome integrity (2016, Mus musculus,Gallus gallus,Xenopus laevis,Cricetus cricetus,Homo sapiens,Caenorhabditis elegans)
• Interplay between Fanconi anemia and homologous recombination pathways in genome integrity (2016, Mus musculus,Gallus gallus,Xenopus laevis,Cricetus cricetus,Homo sapiens,Caenorhabditis elegans)
• Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database (2016, NA)
• Circadian rhythm pathway regulated by CTV-B2, CTV-B6 and CaLas-B232 (2016, Candidatus Liberibacter asiaticus,Homo sapiens)
• Cluster analysis indicates a potential pathway for MWCNT-induced fibrosis based on two distinct phases (2016, NA)
• Scheme of the mechanisms by which the lack of ZO-2 triggered cell hypertrophy (2016, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Pekania pennanti,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Human and rodent adrenal steroidogenic pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Candida dubliniensis,Chrysemys picta,NA)
• A, schematic overview of ChREBP and N-terminal (81–196) regulatory region () and representation of important sites, including the nuclear export signals NES1, NES2, and NLS (2016, NA)
• Schematic summary of the results (2016, Homo sapiens,Mus musculus)
• NFKB signaling pathway with genes associated with objective PNMS (2016, NA)
• Cellular complexity reduced in a reconstituted membrane (2016, Homo sapiens)
• Intrinsic and extrinsic pathways of apoptosis (2016, NA)
• Principal cell death pathways involved in intervertebral disc (IVD) degeneration (2016, NA)
• The Hippo signal transduction network and its links to exercise-associated signals and signalling modules (2016, NA)
• Schematic diagram illustrating lipid droplet formation, VLDL secretion, and pathways involving hepatic inflammation (2016, NA)
• Molecular mechanisms involved in glucosensing in the gastrointestinal tract (2016, NA)
• Notch and Wnt pathway inhibition by natural products (2016, NA)
• GR cross talk with the TLR signaling pathway (2016, NA)
• Cross talk of GR with the STAT signaling pathway (2016, NA)
• Macroautophagy: an overview of the molecular pathway and mutations associated with congenital disorders of autophagy (2016, NA)
• Illustrated summary of Hedgehog pathway and its effetcs at different stages in the formation and progression of ductal pancreatic carcinoma (2016, NA)
• Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet (2016, NA)
• IPA analysis: (Panel a) Top Network Cell Death and Survival, Inflammatory Response, Cancer (2016, Escherichia coli,Lactiplantibacillus plantarum,Bifidobacterium longum,Lacticaseibacillus paracasei,Homo sapiens,Mus musculus,Sequoia sempervirens)
• The GLUD2 genotype effect on mouse metabolome (2016, Homo sapiens,Mus musculus,Alocasia macrorrhizos)
• Both the EMP (red) and the OPP (blue) pathways share intermediates with the Calvin–Benson cycle (circled in red), but not the ED (green) pathway (2016, Hordeum vulgare,PX clade,Synechocystis sp.)
• Novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• VE-cadherin cleavage by ovarian cancer microparticles induces Beta-catenin phosphorylation in endothelial cells (2016, Bos taurus,Capra hircus,Lareunionomyces loeiensis,Triticum aestivum,Homo sapiens,Mus musculus)
• Protein kinase D2 contributes to TNF-Alpha-induced epithelial mesenchymal transition and invasion via the PI3K/GSK-3B/Beta-catenin pathway in hepatocellular carcinoma (2016, Homo sapiens,Mus musculus,Bos taurus)
• Triptolide induces protective autophagy through activation of the CaMKKBeta-AMPK signaling pathway in prostate cancer cells (2016, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Tripterygium wilfordii,Momordica charantia,Mus musculus,Rattus norvegicus,Homo sapiens,Phenes raptor,NA)
• Notch and Wnt/Beta-catenin signaling pathway play important roles in activating liver cancer stem cells (2016, NA)
• Metabolic changes triggered by ischemic insult and possible evolutions of the injury with the crosstalk between chemokines (2016, NA)
• Hepatocyte growth factor/mesenchymal epithelial transition factor and phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway, and their inhibitors evaluated in gastric cancer patients (2016, NA)
• Signal transduction pathways that mediate Treg resistance converge on the PI3K/Akt pathway (2016, NA)
• Schematic overview of TLR signaling pathway in neutrophilic and eosinophilic asthma (2016, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Two possible neural circuits which may underlie the generation of the dual-peak response (2016, Mus musculus,Homo sapiens)
• Seasonal bias in toll-like receptor (TLR) signalling pathway (2016, teleost fish,Salmo salar,Dipnomorpha,Gasterosteus aculeatus,Trematomus bernacchii,Schistocephalus solidus,Strongylus vulgaris,Homo sapiens,Mus musculus)
• High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens)
• High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens)
• Combination therapy targeting the MAPK pathway and GPNMB in BRAF mutant melanoma (2016, Bos taurus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus)
• Comparison between Timelines of Transcriptional Regulation in Mammals, Birds, and Teleost Fish Somitogenesis (2016, NA)
• Genes involved in CRC pathway (2016, Homo sapiens,Diaporthe sclerotioides)
• Downstream effects of miR-145 ectopic expression (2016, Homo sapiens,Diaporthe sclerotioides)
• Simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions (2016, NA)
• Identification and Characterization of miRNAs in Chondrus crispus by High-Throughput Sequencing and Bioinformatics Analysis (2016, NA)
• Network analysis of blood transcripts (2016, NA)
• Transsynaptic regulation of endocannabinoid signaling by Beta-neurexins and its implications in synaptic plasticity and diseases (2016, Mus musculus,Homo sapiens)
• ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation (2016, Armoracia rusticana,Carthamus tinctorius,Homo sapiens,Mus musculus,Bos taurus)
• Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism (2016, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Saccharomyces cerevisiae)
• Vascular control of the haematopoietic microenvironment by Slit/Robo signalling (2016, Homo sapiens,Drosophila melanogaster)
• Targeting B-cell receptor signaling in leukemia and lymphoma: how and why? (2016, NA)
• Glycolysis (2016, NA)
• T Cell Receptor (TCR) signaling pathway activation in endometrium of UNINF fetuses (2016, NA)
• Expression of genes that function in leukocyte activation in uninfected fetuses (2016, NA)
• FGF21 induces preventive effect on CVDs through multiple signaling pathways (2016, NA)
• Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis (2016, West Nile virus,Homo sapiens)
• Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis (2016, West Nile virus,Homo sapiens)
• Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis (2016, West Nile virus,Homo sapiens)
• Galectin-3 involvement in tumor progression (2016, Mus musculus,Cricetus cricetus,Homo sapiens,Canis lupus familiaris,Cicer arietinum)
• Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a (2016, NA)
• Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid parasites (2016, NA)
• Role of the FGF/FGFR signaling pathway in the development and progression of HCC (2016, Homo sapiens,Macaca fascicularis,Mus musculus,Hepatitis B virus,NA)
• Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15 (2016, Bos taurus,Equus caballus,Betapolyomavirus macacae,Polyomavirus sp.,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling (2016, NA)
• Genetic networks generated from the differentially expressed genes from adipose tissues (2016, Mus musculus,Homo sapiens)
• MK2/HuR pathway in the post-transcriptional regulation of TNF-Alpha-induced ICAM-1 expression (2016, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Turdus migratorius)
• Shows the schematic presentation of the IFNA/B and IFNG receptors linked to the Jaks for the TO-VS-IFN/SAV3 and TO-VS-SAV3 (2016, Gallus gallus,Danio rerio,Hepatitis B virus,Japanese encephalitis virus,Oncorhynchus mykiss,teleost fish,Sindbis virus,Chikungunya virus,Salmo salar,Dengue virus type 2,Salmo trutta,Siniperca chuatsi,Isavirus salaris,Salmonid alphavirus subtype 3,Salmon pancreas disease virus,Tetraodon fluviatilis,Drosophila melanogaster,Patinopecten sp.,Homo sapiens,Mus musculus)
• Shows Jak/stat pathway analysis for the TO-VS-IFN/SAV3 and TO-VS-SAV3 using the KEGG pathway software analysis (2016, Gallus gallus,Danio rerio,Hepatitis B virus,Japanese encephalitis virus,Oncorhynchus mykiss,teleost fish,Sindbis virus,Chikungunya virus,Salmo salar,Dengue virus type 2,Salmo trutta,Siniperca chuatsi,Isavirus salaris,Salmonid alphavirus subtype 3,Salmon pancreas disease virus,Tetraodon fluviatilis,Drosophila melanogaster,Patinopecten sp.,Homo sapiens,Mus musculus)
• Schema of IR structure and insulin signaling pathways in vascular cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Corynephage beta)
• ASS234 targets involved in AD pathogenesis (2016, Homo sapiens)
• Sclerostin actions (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Oryctolagus cuniculus,Spodoptera frugiperda)
• Signaling pathway diagram generated in Cytoscape software (2016, NA)
• TGFB signaling in fibroblasts (2016, NA)
• Proposed model of Cdk2 phosphorylation of Bcl-xL in cisplatin-induced apoptosis (2016, NA)
• Exposure of MCF-7 cells to 10 nM E2 (A) and 1 μM G-1 (B) induced phosphorylation of proteins involved in cellular processes associated with cell cycle although the specific phosphorylation profiles varied (2016, NA)
• Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling (2016, NA)
• Putative fatty acid synthesis (FAS) pathway in Chaetoceros GSL56 based on functional annotation (2016, NA)
• Suggested positive feedback loop in SOD3 signal transduction (2016, NA)
• Summary of NDR/LATS kinase signalling functioning downstream of Ste20-like kinases and upstream of the Hippo effectors YAP/TAZ (2016, Drosophila melanogaster,Trypanosoma brucei,Conus striatus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Neurospora crassa,Homo sapiens,Canis lupus familiaris,Human immunodeficiency virus 1)
• The calcineurin/NFAT signaling pathway and the miRNAs involved in feedback loops to modulate the pathway activities (2016, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Fzd7 receptor complexes and signalling output (2016, NA)
• Parallelism between MAPK signalling cascades in yeast and in mammalian cells (2016, NA)
• Major players implicated in the phenotypes associated with the deletion of GUP1 in S (2016, NA)
• Hh signaling within the developing TMJ (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Simplified scheme of the cilia-mediated HH signal transduction pathway in vertebrates (2016, NA)
• Proposed pathway of ASPE signaling in MDA-MB-231 cells (2016, PX clade,Curcuma longa,Camellia sinensis,Daucus carota,Rheum rhabarbarum,Saccharina japonica,Viscum album,Rheum tanguticum,Palisada papillosa,Boehmeria siamensis,Homo sapiens,Mus musculus,Bos taurus)
• Schematic of flowering regulatory networks in Chrysanthemum morifolium (2016, NA)
• Components of the TLR signaling network frequently mutated in lymphoid neoplasms (2016, Homo sapiens,Mus musculus)
• EPO-induced intracellular signaling pathways Erythropoietin and its receptor signaling through JAK2 activate multiple downstream signaling molecules including STAT5, PI3K/Akt, NFKB, and MAPK (2016, NA)
• Diversity in GPCR-mediated regulation of Wnt/Beta-catenin (2016, NA)
• GPCR-mediated transactivation of EGFR (2016, NA)
• DNA damage response of human cells with differing p53 status discussed in this article (2016, NA)
• MiRNAs in cardiac fibrosis pathway (2016, NA)
• MiRNAs in cardiomyocyte apoptosis pathway (2016, NA)
• miRNA network regulating cancer metabolism (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Cross-talk between cancer cells and cancer-associated fibroblasts (CAFs) in the regulation of miRNA expression (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification (2016, NA)
• Signalling pathway activated by B1 receptor agonists leading to the formation of ONOO¯ upon post‐translational activation of iNOS and NADPH oxidase (2016, NA)
• Biological interaction network revealed by Ingenuity Pathway Analysis (2016, NA)
• Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine (2016, Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis)
• Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine (2016, Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis)
• RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells (2016, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Armoracia rusticana)
• Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy (2016, Nicotiana tabacum,Camellia sinensis,Senegalia senegal,Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila (2016, Drosophila melanogaster,Anopheles gambiae,Plasmodium vivax,Anopheles aquasalis,Leptopilina boulardi,Saccharomyces cerevisiae,Matthiola incana,Enterococcus faecalis,Methylobacter luteus,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Drosophila C virus)
• Proposed model for metabolic pathways interacting with GAPCp activity (2016, NA)
• Proposed crosstalk between EGFR signaling pathway and Hippo pathway in the diabetic kidney (2016, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Kynurenine pathway of tryptophan metabolism (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Escherichia coli)
• Tumor suppressive Notch signaling involved in the tumorigenesis of CSCC (2016, NA)
• General BMP4 cellular signalling pathway (2016, NA)
• Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state (2016, Homo sapiens,Bos taurus)
• Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state (2016, Homo sapiens,Bos taurus)
• Targeting Notch to overcome radiation resistance (2016, NA)
• IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway (2016, NA)
• RSV Induces a Non-Canonical UPR Response (2016, Dengue virus,Respiratory syncytial virus,West Nile virus,Measles morbillivirus,Human orthopneumovirus,SARS coronavirus NS-1,Human metapneumovirus,Tick-borne encephalitis virus,SARS coronavirus LC3,Mus musculus,Cavia porcellus,Homo sapiens,NA,NA,NA,NA,NA,NA,NA,NA)
• Proposed model of Ca2+ signaling in PCV2-induced autophagy in PK-15 cells (2016, Hepatitis B virus,Human gammaherpesvirus 4,West Nile virus,Rift Valley fever virus,Porcine circovirus 2,Porcine circovirus,Porcine circovirus 1,Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Sus scrofa domesticus,Caenorhabditis elegans,Discosoma sp.,Homo sapiens,Mus musculus,Armoracia rusticana,vectors,Corynebacterium phage gamma)
• Role of stromal cell-derived factor 1A pathway in bone metastatic prostate cancer (2016, Homo sapiens,Mus musculus)
• Luteolin (Lut)-induced apoptosis and autophagy in cancer cells (2016, Allium cepa,Daucus carota,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Perilla frutescens,Limoniastrum guyonianum,Helichrysum pamphylicum,Mus musculus,Rattus norvegicus,Gallus gallus,Opsanus beta,Homo sapiens,Canis lupus familiaris)
• Luteolin (Lut) modulates cancer cell cycle progression (2016, Allium cepa,Daucus carota,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Perilla frutescens,Limoniastrum guyonianum,Helichrysum pamphylicum,Mus musculus,Rattus norvegicus,Gallus gallus,Opsanus beta,Homo sapiens,Canis lupus familiaris)
• Mechanism of luteolin (Lut)-triggered TNF-Alpha-induced cancer cell apoptosis (2016, Allium cepa,Daucus carota,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Perilla frutescens,Limoniastrum guyonianum,Helichrysum pamphylicum,Mus musculus,Rattus norvegicus,Gallus gallus,Opsanus beta,Homo sapiens,Canis lupus familiaris)
• Luteolin (Lut) modulates the Raf/PI3K signaling pathway in KRAS and BRAF mutated cancer cells and HER2-overexpressing cancer cells (2016, Allium cepa,Daucus carota,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Perilla frutescens,Limoniastrum guyonianum,Helichrysum pamphylicum,Mus musculus,Rattus norvegicus,Gallus gallus,Opsanus beta,Homo sapiens,Canis lupus familiaris)
• Possible molecular targets whereby luteolin (Lut) inhibits the invasion of cancer cells (2016, Allium cepa,Daucus carota,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Perilla frutescens,Limoniastrum guyonianum,Helichrysum pamphylicum,Mus musculus,Rattus norvegicus,Gallus gallus,Opsanus beta,Homo sapiens,Canis lupus familiaris)
• Schematic diagram demonstrating the immunomodulatory and therapeutic effects that grafted stem cells exerted on the recipient upon transplantation (2016, Human gammaherpesvirus 4,unidentified influenza virus,adeno-associated virus 2,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Escherichia coli,prion,vectors,Equus asinus,NA)
• Hacker within! Ehrlichia chaffeensis Effector Driven Phagocyte Reprogramming Strategy (2016, Ehrlichia chaffeensis,Homo sapiens)
• Survival strategies used by E (2016, Ehrlichia chaffeensis,Homo sapiens)
• Cell stress pathway evoked by laser phototoxicity involves specific molecules within the endoplasmic reticulum (2016, NA)
• Roles of sclerostin, Lrp4 and Wls in Wnt/Beta-catenin signals in osteoblasts (2016, Homo sapiens,Mus musculus)
• P2-dependent activation of the IRK/PI3K/Akt pathway (2016, NA)
• Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis,Escherichia coli MP1)
• Drosophila and vertebrate patched orthologs share a similar cis-regulatory architecture and gene regulatory strategy (2016, NA)
• Proposed working model for Fbxo21-mediated innate antiviral response (2016, Human alphaherpesvirus 1,unidentified influenza virus,Vesicular stomatitis virus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Escherichia coli,vectors)
• Hepatic fibrosis/hepatic stellate cell activation canonical pathway (2016, Homo sapiens)
• BMP signaling pathway overlapped with the results of the comparison BAVc vs (2016, Homo sapiens)
• TLR4 intracellular signaling pathways (2016, NA)
• Hydrogen sulfide metabolite trimethylsulfonium is found in human urine (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Multiple somatic alterations in components within the same pathways (2016, Homo sapiens,Mus musculus,vectors)
• The mechanisms of action of ANG Secreted ANG undergoes receptor-mediated endocytosis from the cell surface to the inside of the cell where it accumulates in the nucleoli under growth conditions or in the cytoplasm under stress conditions (2016, NA)
• Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle (2016, NA)
• Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle (2016, NA)
• High glucose on inflamed human vascular smooth muscle cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Moloney murine leukemia virus)
• Model of insulin signalling pathway (2016, NA)
• Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype (2016, NA)
• p27 regulates cell migration (2016, NA)
• p27 in cell-cycle regulation (2016, NA)
• Comparison of cAMP metabolism and intracellular signaling pathway in Treg and Tcon subsets (2016, NA)
• cAMP intracellular signaling pathways in target cells of Treg suppression (2016, NA)
• TLRs reside on the plasma membrane or intracellularly on endosomes and act via the MyD88 or the TRIF pathway leading to the activation of downstream signaling pathways (2016, NA)
• Schematic depiction of oncogenic MYC signal transduction (2016, NA)
• Hypothetical model for the role of SbSLSP in abiotic stress tolerance (2016, NA)
• Autocrine acetylcholine induced by IL-17A, via NFKB and ERK1/2 pathway activation, promotes MUC5AC and IL-8 synthesis in bronchial epithelial cells (2016, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• MWCNTg promote the EMT through the TGF-Beta-mediated Akt/GSK-3B/SNAIL-1 pathway (2016, NA)
• Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells (2016, NA)
• Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells (2016, NA)
• Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells (2016, NA)
• Molecular mechanisms of long noncoding RNAs on gastric cancer (2016, NA)
• Fatty acid activated PPARG promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter (2016, NA)
• Detailed metabolic reconstruction of Calditenuis aerorheumensis from OS based on environmental genome sequence and standardized mRNA reads (reported as RPKM; ) (2016, NA)
• Sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met (2016, NA)
• Genes and biological processes shared in Parkinson’s disease (PD) and cancer (2016, NA)
• MiRs and their targets in signaling pathway of LSCC (2016, NA)
• Regulation of insulin-like growth factor 1 receptor signaling by microRNA-4458 (2016, NA)
• Visualisation of differences in glycolysis, TCA-cycle, valine metabolism and erythromycin biosynthesis at three omics levels (2016, NA)
• Single-step pharmacologic strategies in chronic respiratory disease of approved and under-development EGFR pathway inhibitors compared to spermidine activity (2016, NA)
• Role of Spermidine-TCPTP in the complex dynamics of pro- and anti-autophagic factors (2016, NA)
• Rapid degradation of HIF-1A by the ubiquitin-proteasome pathway, during normoxia (2016, Mus musculus,Homo sapiens)
• Mechanotransduction of Neural Cells Through Cell–Substrate Interactions (2016, NA)
• Intracellular interplay between Notch signalling pathway and EMT circuit and Notch signalling tissue patterning outcomes (2016, NA)
• MicroRNAs targeting TGFB signalling underlie the regulatory T cell defect in multiple sclerosis (2016, NA)
• G-protein–coupled receptor (GPCR) signaling pathway (2016, Saccharomyces cerevisiae,Triticum aestivum,Komagataella pastoris,Homo sapiens,Bos taurus,Oryctolagus cuniculus,Macaca fascicularis,Qubevirus durum,Cystovirus phi6,Mus musculus,Escherichia coli,Human immunodeficiency virus,vectors)
• Selected mechanisms potentially involved in TGFB–mediated epithelial–mesenchymal transition (EMT) (2016, NA)
• Cytoscape Pathway Classification Network view of CRC versus adjacent mucosa metabolites (2016, NA)
• Schematic anti-inflammatory signaling pathways activated by nAChR A7 (2016, Nicotiana tabacum)
• Stepwise phosphorylation of p65 promotes NFKB activation and NK cell responses during target cell recognition (2016, NA)
• Photodynamic therapy inhibit Fibroblast Growth Factor-10 induced keratinocyte differentiation and proliferation through ROS in Fibroblast Growth Factor Receptor-2b pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Cutibacterium acnes)
• Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway (2016, NA)
• Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross (2016, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens,Caenorhabditis elegans)
• The enzyme modules incorporated into the RBC metabolic network (2016, Escherichia coli,Corynebacterium glutamicum,Escherichia coli IS5,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Main pathways regulated by the BCR-ABL1 protein (2016, NA)
• Signaling pathways that control coupling in two types of retinal neuron (2016, Danio rerio,Xenopus laevis,Cyprinus carpio,Carassius auratus,Merluccius merluccius,catfish,Perca fluviatilis,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Olea europaea,Pleocyemata sp.)
• Involvement of Notch in the regulation of myelination and axonal growth (2016, NA)
• NRG/Erb signaling in the control of peripheral myelination and axonal growth (2016, NA)
• Cyclic AMP immunoregulatory pathways inhibit TCR signaling and T-cell activation (2016, NA)
• Localization of AKAPs in T cells (2016, NA)
• Sorafenib induces autophagy response through modulation of the main downstream factors and pathways (2016, NA)
• Macrophage Migration Inhibitor Factor Upregulates MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Olea europaea,Aframomum melegueta,Homo sapiens)
• Glucose induced activation of canonical Wnt signaling pathway in hepatocellular carcinoma is regulated by DKK4 (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Hepatitis B virus,Trigonella foenum-graecum)
• Hub-pathway network of GSZD (2016, NA)
• Integrated Analysis of the Roles of Long Noncoding RNA and Coding RNA Expression in Sheep (Ovis aries) Skin during Initiation of Secondary Hair Follicle (2016, NA)
• Model proposing a role for cocaine-induced activation of p38 MAPK/MSK1 signaling pathway in the induction of HIV-1 transcription in macrophages (2016, Bos taurus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus,Armoracia rusticana,Meleagris gallopavo,NA)
• Schematic summarizing the oxidative stress mediated apoptotic pathway through which manganese causes the dopaminergic cell death and is involved in neurotoxic effects (2016, NA)
• Schematic shows the potential role of epigenetic mechanism that may be involved in manganese induced chronic neurotoxic effects and in pathology of Parkinson's disease (2016, NA)
• Canonical Wnt signalling involves binding of Wnt to LRP5/6 and its coreceptor Frizzled resulting in the phosphorylation of LRP5/6 thus permitting Axin to bind to the receptor complex (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Diaporthe sclerotioides,unidentified)
• Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase (2016, Saccharomyces cerevisiae,Homo sapiens)
• The role of REDD1 in the regulating muscle protein balance in response to acute alcohol (2016, NA)
• Regenerative Medicine: Charting a New Course in Wound Healing (2016, Homo sapiens)
• Induction of oxidative stress and defense pathways (2016, NA)
• Metabolic reprogramming for NADPH production (2016, NA)
• Constitutive CBM signaling in B- and T-cell malignancies (2016, NA)
• Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations (2016, NA)
• HCV-Mediated Apoptosis of Hepatocytes in Culture and Viral Pathogenesis (2016, NA)
• Signaling pathways regulating Müller glia cell dedifferentiation and proliferation following retinal injury in zebrafish (2016, Gallus gallus,Danio rerio,Xenopus laevis,teleost fish,Carassius auratus,Pleurodeles waltl,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• In-depth comparative transcriptome analysis of intestines of red swamp crayfish, Procambarus clarkii, infected with WSSV (2016, NA)
• Cilia-mediated signaling pathways whose proper regulation is dependent on the proteasome and the structure of the proteasome (2016, NA)
• Activation of NFKB and STATs signaling pathway in ZIKV-infected hNPCs (2016, Zika virus,Homo sapiens)
• Protein pathway driving the migraine process at the tripartite synapse (2016, Syringa vulgaris,Bromelia plumieri,Homo sapiens,Mus musculus,Danio rerio)
• Current understanding of the HOG pathway architecture in W (2016, Saccharomyces cerevisiae,Wallemia ichthyophaga,Homo sapiens)
• Disturbed metabolic pathway related to NAFLD and HD-TE treatment (2016, NA)
• Antigen processing through MHC I molecules (2016, NA)
• Hierarchical protein binding at the rDNA locus and intersections with SUMO (2016, Saccharomyces cerevisiae,Homo sapiens)
• Schematic description of multiciliogenesis (2016, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• Intersection between the Ras and the SUMO pathway in cancer (2016, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Common vesicular trafficking module in the assembly of the immune synapse and the primary cilium (2016, NA)
• Mechanism of retention of BRCA1/BARD1 complexes at DNA double-strand break sites (2016, Saccharomyces cerevisiae,Homo sapiens)
• Regulators of phenotypic plasticity (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Regulation of Smad4 by the FGF/MAPK and Wnt signaling pathways (2016, Homo sapiens,Mus musculus)
• Ras mitogenic signaling (2016, NA)
• Cancer stem cells and signaling pathways in radioresistance (2016, NA)
• Cancer stem cells and signaling pathways in radioresistance (2016, NA)
• Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome (2016, Homo sapiens,Mus musculus,Human papillomavirus,clinical samples,Eucalyptus intertexta)
• hMENA11a delivers survival signals and promotes resistance to PI3K inhibition (2016, NA)
• Diesel Exhaust Particles Upregulate Interleukins IL-6 and IL-8 in Nasal Fibroblasts (2016, Armoracia rusticana,Ambrosia artemisiifolia,Homo sapiens,Mus musculus,Bos taurus,Moloney murine leukemia virus)
• Mycobacterial mechanism of MAPK pathway control during C (2016, NA)
• Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes (2016, NA)
• TGFB signaling pathway (2016, NA)
• Reactome pathway diagram, demonstrating the primary signaling and functional molecular pathways of the complement system on a target cell (2016, NA)
• Putative model of pVHL-, B-Myb-, and HIF-2Alpha-mediated regulation of tumorigenesis (2016, Mus musculus,Homo sapiens)
• Paths used to facilitate literature validation (2016, NA)
• Molecular mechanisms of cisplatin resistance in cervical cancer (2016, NA)
• SBGN representation of the haematopoiesis gene regulatory network generated by ChiBE () based on our BioPAX model (2016, NA)
• SBGN representation of the WNT/Beta-catenin signaling pathway generated by ChiBE () based on our BioPAX model (2016, NA)
• Curcumin regulated signaling networks (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Nicotiana tabacum,Mycobacterium phage Pinto)
• Schematic showing the effects of RBE on LPS-activated microglia (2016, NA)
• Innate sensing of Toxoplasma gondii and Plasmodium sp (2016, NA)
• Molecular mechanisms whereby RAS promotes cell senescence (2016, NA)
• Mechanistic consequences of PREX2 truncating mutations (2016, NA)
• Proposed model (2016, NA)
• mTOR signaling pathway (2016, NA)
• Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast (2016, NA)
• Overlapping type I, II and III IFN signaling pathways (2016, NA)
• Therapeutics in development target the IFN pathway in SLE (2016, NA)
• Differentially expressed proteins involved in the pathway of Alzheimer׳s disease (2016, NA)
• Mechanisms involved in the interactions between autophagy and inhibitory cytokines (2016, NA)
• Union of active TF-miRNA regulatory pathway in CDDP resistance (2016, Homo sapiens)
• Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection (2016, NA)
• Interaction and expression pattern of SDEGs involved in canonical interferon signaling pathway in Mtb-infected mouse lungs with or without CC-11050 treatment (2016, Mycobacterium tuberculosis,Homo sapiens)
• Aspirin blocks signaling pathway involved in platelet activation as laid out by our algorithm (2016, NA)
• Tumor-supportive effects of BMAT (2016, NA)
• Interactions of oxidative stress, inflammation, insulin resistance, and hyperandrogenemia are described briefly in the figure, which are all involved in polycystic ovary syndrome physiopathology (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Tissue‐specific function of Blimp‐1 expression in dendritic cells (2016, NA)
• Axon guidance pathway involving neuropilin 1 (2016, Mus musculus,Cricetulus griseus,Homo sapiens,Drosophila melanogaster)
• Schematic depiction of the chemo-mechanical coupling and stress-dependent feedback mechanisms in our model (2016, NA)
• Beclin-1 interaction complexes Atg14L and UVRAG/Bif-1 activate the Beclin-1 complexes and induce the formation of autophagosomes in a mutually exclusive manner (2016, NA)
• Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction (2016, NA)
• The regulatory network governing L1 development in response to nutrient availability (2016, Caenorhabditis elegans,Homo sapiens)
• Axels and brakes in the immune reaction (2016, NA)
• Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects (2016, NA)
• Schematic illustration showing the TGFB1-associated Smad pathway in normal (a) and inflamed (b) intestine (2016, Homo sapiens,Mus musculus)
• Epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells (2016, NA)
• ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance (2016, Homo sapiens,Mus musculus,NA)
• ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance (2016, Homo sapiens,Mus musculus,NA)
• Gene of the month: SMARCB1 (2016, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human papillomavirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• The colonocytes showing how deficiency in intestinal CaSR results in increased gut permeability and inflammation (2016, Escherichia coli,Listeria monocytogenes,Citrobacter rodentium,Salmonella enterica subsp. enterica serovar Enteritidis,Blautia coccoides,Mus musculus,Rattus norvegicus,Glycine max,Cavia porcellus,Cyamopsis tetragonoloba,Tanacetum vulgare,Bos taurus,Sus scrofa,Triportheus paranensis,Pollachius pollachius,Homo sapiens,unidentified,human gut metagenome)
• This figure describes the molecular pathways involved in microbiota-host interactions and the development of oral mucositis (2016, NA)
• Critical Role of COI1-Dependent Jasmonate Pathway in AAL toxin induced PCD in Tomato Revealed by Comparative Proteomics (2016, Arabidopsis thaliana,Nicotiana tabacum,Glycine max,Solanum lycopersicum,PX clade,Medicago truncatula,Pyrus communis,Alternaria alternata,Alternaria alternata f. sp. lycopersici,Nicotiana umbratica)
• Alternative complement pathway and the formation of the C3 convertase (2016, Homo sapiens,Mus musculus,Danio rerio,Centrodontus atlas)
• The biologic role of TRIM11 in lung cancer (2016, Homo sapiens,Bos taurus,Armoracia rusticana)
• Schematic of the mechanisms by which A29-V40 peptide activates Nox2 (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Cell signaling pathway through which DD complex elicits a balance between survival and programmed cell death (2016, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis,Molluscum contagiosum virus,NA)
• Autophagy and some of its regulatory pathways Binding of insulin or growth factors to the insulin receptor triggers the PI3K pathway, converting PIP2 into PIP3 that recruits PDK1 and Akt to the plasma membrane (2016, NA)
• ARID1A mutation and anticancer agents on the PI3K/AKT pathway (2016, NA)
• Melatonin pathway and melatonin candidate genes (2016, Pyrus communis,Bikinia letestui,Homo sapiens,Rattus norvegicus,Corynephage beta)
• PC cycle and routes of PCho accumulation (2016, Homo sapiens,Mus musculus)
• Autophagy and apoptosis in the early and late stage of IAV-SP mixed infection (2016, NA)
• Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells (2016, Homo sapiens,Mus musculus,Bos taurus,Salmonella enterica subsp. enterica serovar Typhimurium)
• Link between DNA damage and transcription, and pathway of DSB-induced transcriptional repression (2016, NA)
• IPostC significantly protects hearts against I/R injury, but its molecular mechanisms remain poorly understood (2016, NA)
• Metabolic pathway of aerobic glycolysis, FAS and FAO (2016, Homo sapiens,Mus musculus,unidentified)
• MyD88-dependent pathway (2016, NA)
• The MyD88-independent pathway (2016, NA)
• Graphical abstract (2016, NA)
• EPA, but not AA, therapy induces adaptive autophagy in Dex-induced apoptotic mBMMSCs and maintains the proliferative ability via GPR120-mediated AMPK-mTOR signaling pathway (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Bos taurus)
• Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis (2016, Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli 27A,Homo sapiens,vectors)
• Differential responses of Trans-Resveratrol on proliferation of neural progenitor cells and aged rat hippocampal neurogenesis (2016, NA)
• Networks of candidate cancer genes predicted by MUFFINN and their direct neighbors on HumanNet (2016, NA)
• MiR-548, miR-27, miR-346, miR-218, miR-34a, miR-21, miR-22 and miR-29b promote the osteogenic differentiation of mesenchymal stem cells through Wnt/catenin, Notch, TNFA, TGFB/BMP signaling pathways (2016, Homo sapiens,Mus musculus,Gallus gallus,Bos gaurus)
• MAPK signaling pathway (orange nodes are associated with upregulated or only whole dataset genes and green nodes have no significance) (2016, Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli 14A,Homo sapiens,Bos taurus)
• The podocyte and the glomerular filtration barrier (GFB) (2016, NA)
• TLR4 (toll-like receptor 4) signaling: MyD88 (myeloid differentiation primary response 88)-dependent and MyD88-independent pathways mediate TLR4 signaling (2016, Mus musculus,Homo sapiens)
• Alternate complement pathway (2016, NA)
• Integrated microRNA, gene expression and transcription factors signature in papillary thyroid cancer with lymph node metastasis (2016, Homo sapiens,Caenorhabditis elegans)
• Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq (2016, Escherichia coli,Homo sapiens)
• Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq (2016, Escherichia coli,Homo sapiens)
• Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq (2016, Escherichia coli,Homo sapiens)
• Summary of cellular synthesis pathway for free DXA3 by human platelets (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Regulation of AMPK by metabolic stress, LKB1, and intracellular Ca++ (2016, NA)
• Representative signaling in the AMPK pathway by various AMPK activators (2016, NA)
• Signaling model at a glance (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human gammaherpesvirus 4)
• O-GalNAc glycosylation pathway (2016, NA)
• An illustration showing roles or functions of analyzed retinal disease-related genes (2016, NA)
• Dysfunctional HDL and atherosclerotic cardiovascular disease (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana)
• Predicted FA and TAG biosynthetic pathways in perilla seeds (2016, Perilla frutescens,Homo sapiens)
• Distribution, variety, and frequency of fusion events in riboflavin biosynthesis (2016, Escherichia coli,Bacillus subtilis,Escherichia coli K-12,Escherichia coli str. K-12 substr. MG1655,Cereibacter sphaeroides,Methanocaldococcus jannaschii,Acinetobacter baylyi ADP1,Klebsiella pneumoniae MGH 78578,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Tetrahymena thermophila)
• Mechanisms responsible for aldosterone synthesis in zona glomerulosa cells under normal physiological conditions and excess production in primary aldosteronism (2016, NA)
• Involvement of Cl−/HCO3− exchanger SLC26A3 and SLC26A6 in preimplantation embryo cleavage (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Cavia porcellus,Macaca mulatta)
• Global transcriptome changes in perennial ryegrass during early infection by pink snow mould (2016, NA)
• Illustration of metabolic pathways reported to have altered gene and metabolite expression by integrated pathway analysis (MetaboAnalyst) (2016, Homo sapiens)
• BCR-ABL1 Signaling Network (2016, Homo sapiens,Mus musculus)
• YAP/TAZ mechano-sensing signaling pathway network (2016, NA)
• Classification pathway for primary lymphedema (2016, NA)
• Glucocorticoid-mediated modulation of pro-inflammatory pathways (2016, NA)
• Minocycline-activated anti-inflammatory response through NFKB signaling pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• BDNF and TrkB signaling pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Summary of the signalling pathways known to control the switch between dauer and growth in C (2016, Drosophila melanogaster,Caenorhabditis elegans,Acyrthosiphon pisum,Ascaris suum,Haemonchus contortus,Trichinella spiralis,Caenorhabditis briggsae,Brugia malayi,Pristionchus pacificus,Strongyloides stercoralis,Trichuris suis,Necator americanus,Caenorhabditis remanei,Ancylostoma caninum,Toxocara canis,Bursaphelenchus xylophilus,Strongyloides ratti,Heterorhabditis bacteriophora,Caenorhabditis brenneri,Meloidogyne hapla,Tritrichomonas muris,Loa loa,Caenorhabditis sp.,Parastrongyloides trichosuri,Pristionchus exspectatus,Steinernema carpocapsae,Panagrellus redivivus,Romanomermis culicivorax,Caenorhabditis angaria,Homo sapiens,Cryptomeria japonica)
• Nucleoprotein complexes associated with mammalian and A (2016, NA)
• Double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression (2016, NA)
• FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Antarctothoa delta)
• Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives (2016, herbal medicine,Magnoliopsida,Epimedium koreanum,Epimedium grandiflorum,Gynura procumbens,Cananga odorata,Elephantopus scaber,Swietenia macrophylla,Nephelium ramboutan-ake,Epimedium elatum,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Capra hircus)
• Tyrosine kinase receptors and their signalling pathways involved in angiogenesis (2016, NA)
• Common mechanisms involved in Alzheimer's disease and type 2 diabetes: a key role of chronic bacterial infection and inflammation (2016, NA)
• Genes involved in circadian rhythm pathway constructed in the IPA program colored according their correlation with circulating levels of tumor necrosis factor alpha (TNFA) (2016, NA)
• Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Gallus gallus,Armoracia rusticana,Renilla reniformis)
• Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Gallus gallus,Armoracia rusticana,Renilla reniformis)
• Anti-tumor effect of Beta-glucan from Lentinus edodes and the underlying mechanism (2016, NA)
• VacA interferes with T-cell activation and proliferation by manipulating the T-cell receptor pathway and the cell cycle (2016, NA)
• Schematic overview of viruses that subvert the PI3K/Akt/mTOR signaling pathway (2016, Human papillomavirus,Respiratory syncytial virus,Vaccinia virus,West Nile virus,Semliki Forest virus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Zika virus,Measles morbillivirus,Betapolyomavirus macacae,Japanese encephalitis virus,Human alphaherpesvirus 3,Sindbis virus,Chikungunya virus,Yellow fever virus,Polyomavirus sp.,Merkel cell polyomavirus,Rift Valley fever virus,Myxoma virus,Porcine circovirus 2,Infectious bursal disease virus,Coxsackievirus A16,Avian orthoreovirus,Porcine circovirus,Alphapolyomavirus muris,Human adenovirus E4,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Drosophila melanogaster,NA,NA,NA)
• Downstream targets of mTORC1 (2016, Vaccinia virus,Chikungunya virus,Merkel cell polyomavirus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Zika virus,West Nile virus,Measles morbillivirus,Betapolyomavirus macacae,Japanese encephalitis virus,Human alphaherpesvirus 3,Sindbis virus,Yellow fever virus,Polyomavirus sp.,Semliki Forest virus,Rift Valley fever virus,Myxoma virus,Porcine circovirus 2,Infectious bursal disease virus,Coxsackievirus A16,Avian orthoreovirus,Porcine circovirus,Alphapolyomavirus muris,Human adenovirus E4,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Drosophila melanogaster,NA,NA,NA)
• HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ (2016, NA)
• Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses (2016, NA)
• FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct (2016, NA)
• Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts (2016, NA)
• Mechanism of stimulated VSMC proliferation through the Wnt4/Dvl-1/Beta-catenin signaling pathway (2016, NA)
• Schematic overview of DNA damaging agents, radiotherapy, DNA damage, the cellular response upon DNA damage, genetic variation, epigenetic regulation and cancer therapy response (2016, Homo sapiens,Mus musculus,Molva molva,Campsis grandiflora)
• Hedgehog signaling pathway and the primary cilia (2016, NA)
• Schema of the central carbon metabolism pathway, including the Embden-Meyerhof-Parnas-pathway (EMP pathway), the pentose-phosphate pathway (PP pathway), and the tricarboxylic acid cycle (TCA cycle) (2016, NA)
• Mechanism of cell death in murine lung epithelial cells after repeated cycles of hyperoxia, radiation, and double-hit combination challenge (2016, NA)
• An illustration of the genesis of exosomal aquaporin-2 (AQP2) in renal collecting duct principal cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Ovis aries)
• Signaling mechanisms of epidermal growth factor receptor (EGFR) transactivation in renal fibrosis (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus)
• Summary of the mechanisms by which stress-related immune alterations may precipitate depression (2016, NA)
• Neuronal CB signaling (2016, NA)
• Long noncoding RNA LINP1 regulates double strand DNA break repair in triple negative breast cancer (2016, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana,Calloplesiops altivelis)
• Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma (2016, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Canis lupus familiaris,Homo sapiens,Saccharomyces cerevisiae)
• Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish (2016, NA)
• Potential drought response signaling pathways in sheepgrass (2016, NA)
• Core Reelin signaling pathway (2016, NA)
• Map of lipid metabolic pathways in C (2016, Cyanidioschyzon merolae,Saccharomyces cerevisiae,Arabidopsis thaliana,Embryophyta,PX clade,Spinacia oleracea,Chlamydomonas reinhardtii,Allium cepa,Chlorophyta,Piromyces finnis,Neopyropia yezoensis,Porphyridium purpureum,Cyanidioschyzon merolae strain 10D,Escherichia coli,Pseudomonas aeruginosa,Synechocystis sp. PCC 6803,Nostoc sp. PCC 7120 FACHB-418,NA,Homo sapiens)
• Deregulated Signaling Networks in Pancreatic Cancer (2016, NA)
• Control of Insulin Secretion by Production of Reactive Oxygen Species: Study Performed in Pancreatic Islets from Fed and 48-Hour Fasted Wistar Rats (2016, NA)
• Fundamentals of cancer metabolism (2016, Homo sapiens)
• Fundamentals of cancer metabolism (2016, Homo sapiens)
• Microenvironmental regulation of oligodendrocyte replacement and remyelination in spinal cord injury (2016, NA)
• Regulation of Hippo signalling in Drosophila melanogaster (2016, NA)
• Cross-talk of mammalian Hippo signalling with the MAPK, PI3K and intrinsic and extrinsic apoptotic pathways (2016, NA)
• DNA end resection dictates the pathway choice for both DNA repair and checkpoint response DSBs can be repaired by NHEJ or by HR that requires 3′ ssDNA generated by end resection (2016, NA)
• Schematic pathway of apoptosis-induction by KTH-13-Me (2016, herbal medicine,Panax ginseng,Agaricus bisporus,Beauveria bassiana,Ophiocordyceps sinensis,Cordyceps militaris,Cordyceps pruinosa,Homo sapiens,Rattus norvegicus,Bos taurus)
• Parts of the signaling pathways of the five mutated proteins in the 5 syndromes of this review (2016, NA)
• Signaling pathways important for stem/progenitor cells regulation (2016, Mus musculus,Rattus norvegicus,Clostridioides difficile,Clostridioides difficile CD3,Homo sapiens,Bos taurus)
• Mitochondrial Quality Control in the Diabetic Heart (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Sugar Synthesis from CO2 in Escherichia coli (2016, Escherichia coli)
• p53 integrates metabolic stress signals to direct cell metabolism (2016, NA)
• p53 regulates carbohydrate metabolism during glucose starvation (2016, NA)
• p53 directs lipid and amino acid metabolism during stress (2016, NA)
• Gene circuits for biomedical applications (2016, NA)
• Mechanotransduction in transcriptional regulation (2016, Homo sapiens,Mus musculus)
• Disruption of miRNA biogenesis by estrogens and cigarette smoke can lead to oncogenesis (2016, NA)
• Relationships between longevity genes affected by the diabetic milieu (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Vasconcellea candicans)
• Intrinsic and extrinsic apoptotic signalling pathways and points of therapeutic intervention (2016, NA)
• Diagrams showing signal transduction pathways used by chemokines and the proinflammatory cytokine IL-6 (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• The Wnt/Beta-catenin signaling pathway in renal cell carcinoma (RCC) (2016, NA)
• The Wnt signaling pathway and possible points for therapeutic interventions to restrict S100A4-mediated tumor progression and metastasis (2016, NA)
• Biosynthetic pathways of anandamide (2016, NA)
• Canonical NFKB pathway (left) induced by signals including antigens, TLR ligands and cytokines such as TNF uses a wide variety of signaling adaptors to engage and activate the IKKB subunit of the IKK complex (2016, NA)
• NFKB signaling consists of two main branches: canonical and non-canonical (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Circuitry of amino acid signalling to MTORC1 (2016, Homo sapiens)
• RAS/RAF/MEK/ERK pathway and mechanisms of resistance to BRAF inhibition (2016, NA)
• Genes which are involved in the telomere maintenance and telomerase activity pathway (2016, Homo sapiens)
• Mitochondrial function in ageing: coordination with signalling and transcriptional pathways (2016, NA)
• Role of reactive oxygen species in age‐related neuromuscular deficits (2016, NA)
• TGFB drives glucose flow through HBP promoting aberrant glycosylation during EMT (2016, NA)
• Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities (2016, Homo sapiens)
• Proposed signaling pathway by which FSH promotes the PKA-dependent phosphorylation of YB-1 on Ser102 to enhance expression of select FSH target genes (2016, NA)
• The proposed T835M-UNC5C- and V642I-APP-induced neuronal death-signaling pathways (2016, NA)
• Blocking TGFB Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRB+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats (2016, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma,Epirrhoe alternata,Aristolochia fangchi)
• Blocking TGFB Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRB+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar Male Rats (2016, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma,Epirrhoe alternata,Aristolochia fangchi)
• TNF-Alpha-induced expression of the inflammation-associated genes mediated by PLCE (2016, Homo sapiens,Mus musculus)
• Role of the 20E-induced cAMP/PKA/CREB signaling in 20E-regulated gene expression (2016, Helicoverpa armigera)
• Signaling pathways involved in platelet-mediated NET formation (2016, NA)
• Multiple modes of action of Mg2+ in attenuating Pi-induced VC in HAVSMC (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Mammalian or mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway (2016, Homo sapiens)
• Mechanism of PDGF-induced SphK1 expression and proliferation of hPASMCs in pulmonary arterial hypertension (PAH) (2016, Homo sapiens)
• Differentially expressed genes in BA, JA and UA groups mapped on the TNFR signaling pathway (1 denotes JA, 2 denotes UA, and 3 denotes BA) (2016, Mus musculus,Homo sapiens)
• Proposed model of miRNA regulation by simvastation and possible protective role of ubiquinol (2016, Homo sapiens)
• Angiocrine mechanisms during fetal lung development (2016, NA)
• Na+-Cl− cotransporter (NCC) regulation by the cullin-3 (CUL3)/kelch-like 3 (KLHL3)-with no lysine (WNK)-STE20/SPS-1-related proline/alanine-rich kinase (SPAK)/oxidative stress response kinase (OSR1) pathway (2016, NA)
• Independent Tumor Origin in Two Cases of Synchronous Bilateral Clear Cell Renal Cell Carcinoma (2016, Homo sapiens)
• LumA-R2 samples overexpress genes in the T cell receptor signaling pathway (2016, NA)
• Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NFKB/p53-apoptosis signaling pathway (2016, NA)
• Cholesterol biosynthesis pathway is altered in CEM/R2 cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Downregulation of the Canonical WNT Signaling Pathway by TGFB1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics (2016, NA)
• GLP‐1 and Wnt signalling in the regulation of bone formation (A) In the inactive state of the Wnt/B‐catenin pathway, Wnt is inhibited by a decoy receptor sFRP, where as its co‐receptor LRP5/6 binds to inhibitory protein sclerostin or Dkk (2016, Homo sapiens,Rattus norvegicus)
• Bacterial components that affect innate and adaptive immunity in the intestine (2016, NA)
• MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy (2016, NA)
• Putative pathway for the inhibition of inflammatory signaling events by AQCA in in vitro inflammatory responses (2016, Armoracia rusticana,Panax ginseng,Petroselinum crispum,Ocimum basilicum,Rheum palmatum,Vigna angularis,Hopea odorata,Ajuga decumbens,Ribes fasciculatum,Wurfbainia compacta,Melicope pteleifolia,Ribes fasciculatum var. chinense,Mus musculus,Rattus norvegicus,Escherichia coli,Helicobacter pylori,Homo sapiens,Bos taurus)
• Effect of SPN on hypoxia-induced retinal angiogenesis (2016, Ligustrum lucidum,Armoracia rusticana,Schisandra chinensis,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,NA)
• The molecular metchanisms of natural polyphenols effects on metastasis (2016, NA)
• Hypothetical mechanism of ursolic acid against MRSA (2016, NA)
• PI3K-Akt-mTOR pathway (2016, NA)
• Proposed signaling pathways for betulinic acid (BA)-induced eNOS activation through phosphorylation of the Ser1177 residue in EA.hy 926 cells (2016, NA)
• Genistein (0.01–10 μM) stimulates breast cancer cell proliferation acting through the classical genomic ER pathway and/or through the fast, non-genomic GPER1-mediated pathway (2016, NA)
• The possible inhibitory mechanism of ethyl acetate fraction of M (2016, NA)
• G2/M DNA damage check point signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• Apoptosis signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• PI3K/Akt signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• mTOR signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• Tight junction signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• Remodeling of epithelial adherent junction signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• UPR signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• ER stress signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• ERK-MAPK signaling pathway was regulated by vancomycin in HK-2 cells (2016, Homo sapiens)
• Schematic diagram of the mechanism by which asiatic acid prevents cardiomyocyte apoptosis (2016, NA)
• Possible signaling pathways for tetrandrine-induced apoptosis in NPC-TW 076 human nasopharyngeal carcinoma cells (2016, NA)
• Capsaicin mediates saliva secretion via transient receptor potential vanilloid subtype 1 (TRPV1) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Helicobacter pylori,Capsicum frutescens)
• Proposed mechanisms of 3EZ, 20Ac-ingenol-induced cell apoptosis in hepatocyte L-O2 cells (2016, Euphorbia kansui,Homo sapiens,Rattus norvegicus,Bos taurus,Nilaparvata lugens,NA)
• Extension of the Saccharomyces cerevisiae heterologous reticuline biosynthetic pathway for the production of precursors of the berberine- and sanguinarine-type benzylisoquinoline alkaloids (in black) and the morphinan alkaloids (in red) (2016, Saccharomyces cerevisiae,Homo sapiens)
• Upstream signal transduction pathway leading to activation of canonical p50/p65 NFKB upon stimulation by tumor necrosis factor (TNF)A (see text for details, scheme realized with ScienceSlides) (2016, Saccharomyces cerevisiae,Diaporthe sclerotioides,Hordeum vulgare,Panax ginseng,Allium sativum,Glycyrrhiza glabra,Alternaria brassicicola,Aloe vera,Fusarium sp.,Butea monosperma,Valeriana officinalis,Zingiber zerumbet,Toxicodendron vernicifluum,Boswellia sacra,Epicoccum nigrum,Pochonia chlamydosporia,Hydnophytum formicarum,Helicoma ambiens,Streptomyces hygroscopicus,Pseudomonas sp.,Chromobacterium violaceum,Burkholderia thailandensis,Nocardia sp.,Homo sapiens,Mus musculus,Gallus gallus)
• Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules (2016, NA)
• Proposed scheme to describe how are interconnected with Ca2+-pH signaling components in polar growing cells (2016, NA)
• Genes up- and downstream of flavonol biosynthesis are also affected in the Δy mutants (2016, Arabidopsis thaliana,Solanum lycopersicum)
• Connection between chloroplast redox/ generation and cytosolic signaling pathways (2016, NA)
• Pathway diagram of the glycolysis pathway (2016, NA)
• Pathway diagram of the genes in the tricarboxylic acid cycle (2016, NA)
• Bile acid metabolism in the liver (2016, NA)
• Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana)
• cGMP-PKG signalling in the cardiomyocyte (2016, NA)
• Surviving problems during chromosome replication (2016, NA)
• Candidate SCI biomarker input for Systems Biology and pathway network analysis (2016, NA)
• Three pathways identified as altered based on the 12 SCI biomarker candidate proteins as input (2016, NA)
• AhRR repression on AhR activity and the consequences in endpoints (2016, Homo sapiens,Hepatitis B virus,Macaca mulatta,Moloney murine leukemia virus,Mus musculus,Oryctolagus cuniculus,Zea mays,Helicobacter pylori)
• Schematic diagram illustrating the different mechanisms by which P2 receptor subtypes might alter cancer cell function (2016, NA)
• Signals shared after brain injury and in the NSC niche (2016, NA)
• Enhanced Ca2+ and ROS levels in cardiac hypertrophy (2016, Rattus norvegicus,Homo sapiens)
• Dysregulation of Ca2+ and redox signalling in Alzheimer's disease (AD) (2016, Rattus norvegicus,Homo sapiens)
• Whole Genome Pathway Analysis Identifies an Association of Cadmium Response Gene Loss with Copy Number Variation in Mutant p53 Bearing Uterine Endometrial Carcinomas (2016, Homo sapiens,Gorilla gorilla,Mus musculus,NA)
• Arginine-vasopressin (AVP) signal transduction pathway in the collecting duct (2016, Homo sapiens)
• Metabolites involved in Glycolysis and Amino Acid Metabolism are Altered in Short Children Born Small for Gestational Age (2016, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Bos taurus)
• Effect of CX3CL1/CX3CR1 in Alzheimer's disease (AD) (2016, NA)
• Circadian Rhythm Signaling pathway (2016, NA)
• Comparison of In Vivo Gene Expression Profiling of RPE/Choroid following Intravitreal Injection of Dexamethasone and Triamcinolone Acetonide (2016, NA)
• Signal pathways of migration inhibitory factor (MIF) (2016, NA)
• Composite changes in markers of the insulin-signaling pathway and their relationship with insulin sensitivity in the liver (left panel), muscle (middle panel), and adipose tissue (right panel) in GD90 fetuses (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Zea mays,Ovis aries)
• Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience (2016, NA)
• Differentially expressed gene distribution in the rno03320 pathway (2016, NA)
• Differentially expressed gene distribution in rno03320 pathway (2016, NA)
• Regulation of HH and Wnt/Beta-catenin signaling by 1,25(OH)2D/VDR and calcium/Casr (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Oryza sativa)
• Proposed hypothesis for in vivo antifibrotic signaling pathway of serelaxin in kidney (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Cavia porcellus,Equus asinus,Homo sapiens)
• Strategies for modulating the BMP pathway (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Escherichia coli,Human gammaherpesvirus 4,NA)
• Flux distributions simulated with lMOMA for the mevalonate mutant (A) and the acetate mutant (B) using the improved flux distribution as the reference (2016, Saccharomyces cerevisiae,Homo sapiens)
• Distribution of fluxes in the central metabolism predicted by pFBA for the models: iFF708 (green), iMM904 (blue), iTO977 (orange) and Yeast 6 (black) (2016, Saccharomyces cerevisiae,Homo sapiens)
• Cognitive impairment mediated by the Reelin-Fyn-NR2B signaling pathway in 12-month-old ApoE4-TR mice that underwent early-life early CUMS intervention (2016, NA)
• Excitation–transcription coupling responsible for maladaptive metabolic and antioxidant remodeling in HF (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Sequoia sempervirens)
• Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer (2016, NA)
• Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo (2016, NA)
• Aquaporin 3 promotes the stem-like properties of gastric cancer cells via Wnt/GSK-3B/Beta-catenin pathway (2016, NA)
• Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data (2016, Homo sapiens)
• Overcoming the matched-sample bottleneck: an orthogonal approach to integrate omic data (2016, Homo sapiens)
• Ingenuity pathway analysis revealed hepatocyte growth factor (HGF) as an upstream regulator (2016, Homo sapiens)
• Profiling of Host Cell Response to Successive Canine Parvovirus Infection Based on Kinetic Proteomic Change Identification (2016, NA)
• Pathway analysis using IPA software suggests B3-adrenergic receptor signaling activation in T1D-MSCs, with upregulation of several downstream molecules (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Sequoia sempervirens)
• Agents acting on the renin–angiotensin system pathway ©PharmGKB (2016, Homo sapiens,Citrus x paradisi,Osphranter robustus)
• Destruction complex of beta-catenin in colorectal carcinoma and colonic adenoma (2016, Lareunionomyces loeiensis,Citrus macrophylla,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Melanocyte differentiation pathway dependent on MSHA and ACTH (2016, NA)
• Long-Term Administration of Dehydroepiandrosterone Accelerates Glucose Catabolism via Activation of PI3K/Akt-PFK-2 Signaling Pathway in Rats Fed a High-Fat Diet (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Hunteria umbellata,Homo sapiens,Gallus gallus)
• Working model based on our observations (2016, NA)
• Schematic model of the transcriptional regulation of different TFs playing key roles in cellular dehydration in plants (2016, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Malus domestica,Vitis vinifera,Arachis hypogaea,Sorghum bicolor,Medicago truncatula,Helianthus annuus,Medicago sativa,eudicotyledons,Saccharum officinarum,Gossypium hirsutum,Cicer arietinum,Populus trichocarpa,Vicia faba,Vigna radiata,Brachypodium distachyon,Brassica rapa subsp. pekinensis,Fagopyrum esculentum,Oryza sativa Indica Group,Chrysanthemum x morifolium,Stramenopiles,Setaria italica,Cenchrus americanus,Suaeda salsa,Phyllostachys edulis,Eutrema halophilum,Triticum dicoccoides,Salicornia brachiata,Ramularia collo-cygni,Tripidium arundinaceum,Trifolium alexandrinum,Ralstonia solanacearum,Homo sapiens)
• KEGG pathway (pathways in cancer) analysis with predicated target genes from upregulated miRNAs (2016, NA)
• KEGG pathway (pathways in cancer) analysis with predicated target genes from downregulated miRNAs (2016, NA)
• KEGG pathway (pathways in cancer) analysis with predicated target genes from all selected differentially expressed miRNAs (2016, NA)
• The proposed mode of action of tumor necrosis factor A (TNFA) on the L-type voltage dependent calcium channel (L-VDCC) of the guinea pig airway smooth muscle (2016, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Cavia porcellus,Cavia fulgida,Homo sapiens,Diaporthe sclerotioides)
• Ion transport regulation by mTORC2 and SGK1 in renal principal cells (2016, NA)
• CRT-knockdown correlates with the modulation of p53 and MAPK pathways (2016, Homo sapiens,Mus musculus,Capra hircus,prion)
• FGF/FGFR signaling pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Crosstalk between leukemia cell and BM MSCs (2016, Homo sapiens,Mus musculus)
• Aminoglycerophospholipids and CL biosynthetic pathways in yeast (2016, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Triportheus paranensis)
• PKA signaling pathway in adrenal tumorigenesis and related mouse models (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Bos taurus,Betapolyomavirus macacae)
• WNT/Beta-catenin signaling pathway in adrenal tumorigenesis (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Bos taurus,Betapolyomavirus macacae)
• Major cholesterol metabolism pathways in the liver (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Armoracia rusticana,Glycine max,Papio hamadryas,Xenopus laevis,Anseropoda placenta)
• Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway (2016, Physalis angulata,Physalis pubescens,Physalis minima,Physalis angulata var. villosa,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy (2016, NA)
• PI3K/PKB/mTOR signaling pathway regulates cancer cell metabolism (2016, NA)
• Physical factors regulating lineage commitment of MSCs (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Paraechinus aethiopicus,Homo sapiens,Danio rerio,Mouse mammary tumor virus)
• Apoptosis pathways in various organisms (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Hippopotamus amphibius)
• Network of transcriptional regulation and ligand receptor signaling (2016, NA)
• The proposed model for production of IFNB in response to extracellular dsRNA (2016, Mus musculus,Mus caroli,Homo sapiens)
• Schematic presentation of gene network implicated in TLR signaling pathway (2016, NA)
• Non-canonical autophagy in the clearance of dead cells (2016, Homo sapiens,Mus musculus)
• SOX2-mediated sensing of cytoplasmic DNA and the associated signaling pathway in neutrophils (2016, NA)
• Cascades of the coagulation system (2016, NA)
• Interactions between coagulation and inflammation during IAV infection (2016, NA)
• Signaling in neutrophils to induce NETosis (2016, NA)
• Cancer stem cells supporting activities of CD44v6 (2016, NA)
• CXCR4, a marker of migrating cancer stem cells (2016, NA)
• EpCAM-palmitoylated claudin7 complex in pancreatic cancer stem cells (2016, NA)
• Pathway analysis of network signaling of some of the identified proteins as represented in the ingenuity pathway analysis database (2016, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Polyphenols activate Keap1/Nrf2/ARE pathway and increase the expression of detoxification/antioxidant enzymes.Notes: In the cytoplasm, Keap1 protein is always bound to Nrf2 transcription regulator and prevents its signaling (2016, Glycine max,Curcuma longa,Theobroma cacao,Ginkgo biloba,Scutellaria baicalensis,Brassica rapa,Salvia rosmarinus,Cinchona pubescens,Salvia officinalis,Vitis labrusca,Toxicodendron vernicifluum,Erigeron breviscapus,Alpinia oxyphylla,Dioscorea nipponica,Scoparia dulcis,Citrus depressa,Hultholia mimosoides,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Horizontal cell fate and cell type formation (2016, NA)
• Impact of periostin on cancer with regard to metastatic dissemination (2016, NA)
• Resveratrol and autophagy via the AMPK/SIRT1 signaling pathway (2016, Homo sapiens)
• Targeting the RB-E2F pathway in breast cancer (2016, NA)
• CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Human immunodeficiency virus 1,Raphanus sativus)
• Molecular and physiological defects in mice lacking BRAF and RAF1 in the epidermis (2016, Homo sapiens,Mus musculus,Staphylococcus aureus,Derris trifoliata,Spleen focus-forming virus)
• Functional role of autophagy in gastric cancer (2016, NA)
• MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via c-Met /PI3k/Akt/mTOR pathway (2016, NA)
• Nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells (2016, NA)
• Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint (2016, NA)
• Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters (2016, NA)
• Main posttranslational modification events involved in the activation of response to ICLs (2016, Escherichia coli,Gallus gallus,Xenopus laevis,Streptomyces caespitosus,Homo sapiens,Mus musculus,Bombyx mori)
• ICL repair (2016, Escherichia coli,Gallus gallus,Xenopus laevis,Streptomyces caespitosus,Homo sapiens,Mus musculus,Bombyx mori)
• Chronic administration of aripiprazole activates GSK3Beta-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats (2016, NA)
• Working model of the molecular mechanisms of HDACi (e.g., abexinostat) on human skeletal (mesenchymal) stem cell differentiation into adipocytes and osteoblasts (2016, Homo sapiens)
• Interplay between VEGF and Notch signaling is important for tip and stalk cell differentiation in physiological angiogenesis (2016, Homo sapiens,Mus musculus,Danio rerio,Human gammaherpesvirus 8)
• Schematic diagram illustrates the putative mechanism for BDNF signaling in mediating CGRP expression in DRG (2016, Mus musculus,Rattus norvegicus,Armoracia rusticana,Phellodendron amurense,Homo sapiens,Oryctolagus cuniculus)
• ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle (2016, NA)
• NFKB-mediated regulation of inflammatory and immunosuppressive CD4+ T-cell lineages (2016, NA)
• Proposed IGF‐interaction with PPAR‐G signalling in CVD epigenetics (2016, NA)
• Top network of THC-regulated miRNAs (2016, NA)
• Transcriptome sequencing wide functional analysis of human mesenchymal stem cells in response to TLR4 ligand (2016, NA)
• Changes in transcript abundance of genes involved in central metabolic pathways and bioprocesses in response to elevated CO2 in C-169 (2016, Coccomyxa subellipsoidea,Coccomyxa subellipsoidea C-169,Homo sapiens)
• Molecular mechanism of disc cell senescence (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Nicotiana tabacum,Homo sapiens,Gallus gallus,Human papillomavirus)
• Actin and myosins in mammalian autophagy (2016, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Calloplesiops altivelis)
• New findings on precursors of HSCs (2016, Homo sapiens,Mus musculus)
• Ehrlichia chaffeensis TRP120-mediated activation of canonical Notch signaling pathway and inhibition of TLR2/4 expression (2016, NA)
• Variations on aerobic methionine salvage pathway (2016, Rhodospirillum rubrum,Tetrahymena sp.,Homo sapiens)
• MT functions and regulation at the presynaptic terminal of Drosophila NMJs (2016, NA)
• PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy (2016, Homo sapiens)
• Cholesterol biosynthetic pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• De novo SL biosynthesis and S1P metabolism (2016, NA)
• Nogo-B regulates de novo SL biosynthesis through the inhibition of SPT activity to control vascular tone and BP (2016, NA)
• Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia (2016, NA)
• HRPII recognition by human brain endothelial cells and the intracellular pathway that leads to BBB leakage (2016, Plasmodium falciparum,Homo sapiens)
• VNN1 expression and function can be regulated by Ox-LDL to promote atherosclerosis (2016, Candida dubliniensis,Taraxacum coreanum,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Schematic mechanism of L5 on STRA6 cascade suppression and kidney injury (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Pathway involved in crosstalk among diverse pathways putatively functional in disease responses of Tomato-Scleretonia interaction (2016, NA)
• The proposed signaling pathway (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cavia porcellus,Homo sapiens,Helicobacter pylori,Podocarpus latifolius)
• Presumed neuroanatomical mechanism of the arousal effects of Ca2+ in the dorsal raphe nucleus (DRN) (2016, Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Felis catus,Equus asinus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Homo sapiens)
• Overview on the role of apolipoprotein E (APOE) in the three main pathways of plasma lipoprotein metabolism (2016, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Oryctolagus cuniculus,Nicotiana tabacum,Listeria monocytogenes,synthetic RNA,Thymallus thymallus,NA)
• Schema of upstream and downstream signaling pathways of mTORC1 (2016, Homo sapiens,Capra hircus)
• Quantification of the input-response function of LAT:Grb2:SOS assembly in TCR signaling (2016, NA)
• The SDF1/CXCR4 signaling pathway (2016, Homo sapiens,Mus musculus,Gallus gallus)
• Summary of TGFB signaling during EMT (2016, NA)
• Transmembrane signaling by TGFB (2016, Homo sapiens,Mus musculus,clinical samples)
• Willin, merlin and ezrin are all FERM containing proteins that can influence proper functioning of the cytoskeleton, cell to cell junction complexes (TJ: tight junctions, AJ: adherens junctions) and the hippo signalling pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• NOD-Like Receptors in Infection, Immunity, and Diseases (2016, Bacillus anthracis,Legionella pneumophila,Homo sapiens,Mus musculus,Drosophila melanogaster,Human immunodeficiency virus)
• Replicative aging cooperates with other aging mechanisms to activate the p53 and/or Rb signaling pathways (2016, Saccharomyces cerevisiae,Curcuma longa,Allium sativum,Ginkgo biloba,Astragalus membranaceus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Adeno-associated virus)
• Genome-wide transcriptomic analysis uncovers the molecular basis underlying early flowering and apetalous characteristic in Brassica napus L (2016, NA)
• Antioxidant Protection of NADPH-Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione (2016, NA)
• G protein activation and signaling (2016, Homo sapiens)
• Natural product based novel small molecules with promising neurotrophic, neurogenic and anti-neuroinflammatory actions can be developed as stroke therapeutics (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Examples of biological networks (A) Protein-protein interaction (2016, Homo sapiens,Saccharomyces cerevisiae)
• Representation of the effects of ADAMTS on Tau production (2016, NA)
• IL-6 and IL-11 signaling (2016, Homo sapiens,Mus musculus,Listeria monocytogenes,Human T-cell leukemia virus type I)
• Biosynthetic pathway of essential oil biosynthesis in C (2016, NA)
• Wnt signaling pathway (2016, Homo sapiens,Mus musculus,Helicobacter pylori,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Schematic illustration of the canonical Wnt signal transduction cascade (2016, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer (2016, Gallus gallus,Danio rerio,Xenopus laevis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Comparison of the Drosophila and vertebrate non-canonical Wnt pathways applicable to this proposal (2016, Gallus gallus,Danio rerio,Xenopus laevis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Regulation of genes of Cell Cycle pathway during senescence induction in HFF strains (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Human papillomavirus,Matthiola incana,Human betaherpesvirus 5,Homo sapiens,Dipturus trachyderma,Opisthorchis viverrini)
• Regulation of genes of cell cycle pathway during senescence induction in MRC-5 strains (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Human papillomavirus,Matthiola incana,Human betaherpesvirus 5,Homo sapiens,Dipturus trachyderma,Opisthorchis viverrini)
• Pharmacological targets of ibuprofen (2016, NA)
• Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells (2016, NA)
• Lipid mediators and HIF1A signaling in hypoxic prostate cancer (PCa) cells (2016, NA)
• Flii involvement in inflammation (2016, NA)
• Upregulation of melanogenesis by SOX9 (2016, Gallus gallus,Danio rerio,Xenopus laevis,Thymallus thymallus,Homo sapiens,Mus musculus,Corynephage beta)
• Mechanism and pathway map of the prostate cancer (modified based on KEGG database) (2016, Homo sapiens,Mus musculus)
• Regulation of HER3 and downstream signaling (2016, NA)
• Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment (2016, Homo sapiens,Rattus norvegicus,Armoracia rusticana)
• a) Systems modeling framework used in this study (2016, Homo sapiens,Mus musculus,Escherichia coli,Sorghum bicolor,Cryptosporidium parvum)
• Presence of both alterations in FGFR/FGF and PI3K/AKT/mTOR confer improved outcomes for patients with metastatic breast cancer treated with PI3K/AKT/mTOR inhibitors (2016, Homo sapiens,clinical samples,Corynebacterium phage gamma)
• Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways (2016, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Enhanced inflammatory gene expression by IL1B; feedback control by DUSP1 and feed-forward control by ZFP36 (2016, NA)
• Computational discovery of Epstein-Barr virus targeted human genes and signalling pathways (2016, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• IL-7RA pathway mutations provide potential targets for acute lymphoblastic leukemia therapy (2016, NA)
• Viral oncolysis dependent on RNA-activated protein kinase (PKR) inactivation (2016, NA)
• Signaling pathways activated by ET-1 in cancer (2016, NA)
• 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages (2016, NA)
• The Nrf2-Keap1 pathway (2016, NA)
• SKN-1 in the development of C (2016, NA)
• Regulation of mRNA translation initiation by the mechanistic target of rapamycin complex 1(mTORC1) signaling pathway (2016, NA)
• Proposed cytotoxic mechanisms of NEDDylaton inhibition in human malignancies (2016, Homo sapiens)
• Peroxisome proliferator-activated receptor (PPAR)-related fasting response in heart (2016, NA)
• MMP-9 signaling in the left ventricle following myocardial infarction (2016, NA)
• Schematic summary of novel TXNIP-NFYA-SREBP2/miR-33a-AMPKA/CROT/CPT1/HADHB signaling pathway conferring TXNIP regulation of myocardial fatty acid oxidation (2016, NA)
• Gene repertoire for sterol biosynthesis in unicellular holozoans (2016, NA)
• Epidermal growth factor receptor and its downstream signaling pathway (2016, Homo sapiens)
• Role of guanylate-binding protein-1 in colorectal carcinoma and inflammatory bowel diseases (2016, NA)
• Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM) (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Zea mays,Human gammaherpesvirus 4,clinical samples)
• Schematic illustrating Mekk1 signaling and the regulation of Cdkn1b expression in T cells (2016, NA)
• Retinoid regulation of early lung development (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Autophagy process, apoptosis process and the site of action of sauchinone (2016, NA)
• Proposed model for IFNGamma-induced apoptosis of HNSCC cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Hemerocallis citrina)
• STRING v10.0 protein–protein interaction network based on input of 164 proteins of interest (2016, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Gallus gallus,Diaporthe sclerotioides,Vibrio parahaemolyticus)
• Model deciphers molecular mechanisms by which PRMT5/p44 controls cell growth (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Model summarizing the role of the HH signalling pathway and its primary transducer, GLI2, during mES cell cardiomyogenesis (2016, NA)
• MACC1 participates in multiple biological processes inside and outside of gastric cancer cells, functioning as an important mediator of the tumor microenvironment (2016, Homo sapiens)
• A Review of Melatonin, Its Receptors and Drugs (2016, NA)
• Roles of hBVR in activating IRK/PI3K/Akt pathway (2016, Homo sapiens)
• Regulation of cancer cell functions by hyaluronan (HA)‐receptor interactions (2016, Homo sapiens,Mus musculus,Bos taurus)
• Feedback loops that form the molecular clock (2016, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Cricetulus griseus,Neurospora crassa,Citrus deliciosa,Homo sapiens,Drosophila melanogaster)
• Dynamic mRNA and miRNA expression analysis in response to intermuscular bone development of blunt snout bream (Megalobrama amblycephala) (2016, Megalobrama amblycephala,Homo sapiens)
• Self-renewal pathways in CSCs (A) Wnt signaling pathway, (B) SONIC Hedgehog signaling pathway, and (C) Notch signaling pathway (2016, NA)
• Proposed model for increased IL-6 and leptin production caused by global Zip14 deletion (2016, NA)
• Oncogenic addiction versus synthetic lethality to explain GSK621-induced cytotoxicity in AML (2016, NA)
• FERONIA signaling and related pathways (2016, NA)
• Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration (2016, NA)
• Dual regulation of GSK3 by the PI3K/Akt/GSK3 pathway and PLIN2 (2016, NA)
• Downregulation of PPAR pathway and bile acid biosynthesis and secretion pathway (2016, NA)
• Transcriptome landscape of Synechococcus elongatus PCC 7942 for nitrogen starvation responses using RNA-seq (2016, Escherichia coli,Corynebacterium glutamicum,Synechocystis sp. PCC 6803,Synechocystis sp.,Cupriavidus necator,Synechococcus elongatus PCC 6301,Synechococcus elongatus PCC 7942 FACHB-805,Synechococcus sp. PCC 7002,Microcystis aeruginosa,Saccharomyces cerevisiae,Haematococcus lacustris,Saccharomyces cerevisiae EC1118,Homo sapiens)
• Proteins highlighted for their contributions to molecular regulation in diabetes and heart failure (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Predictive Immunohistochemical Markers Related to Drug Selection for Patients Treated with Sunitinib or Sorafenib for Metastatic Renal Cell Cancer (2016, NA)
• Involvement of AKR1B1 in pathophysiology (2016, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Ambrosia artemisiifolia,Homo sapiens,Oryctolagus cuniculus)
• High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model (2016, NA)
• Proposed signaling pathway in retinal detachment leading to rod terminal retraction (2016, NA)
• The biosynthetic pathway to nicotine and tropine indicating the common and unique steps (2016, NA)
• Schematic showing the roles of EGFR ligands and NRG1 in the regulation of timing of ovulation and oocyte maturation (2016, Mus musculus,Homo sapiens)
• Wnt signaling in implantation and decidualization events (2016, Homo sapiens)
• Wnt‐cGMP/Ca2+pathway (2016, Homo sapiens)
• Wnt/PCP pathway (2016, Homo sapiens)
• B‐Catenin‐dependent pathway (2016, Homo sapiens)
• Signal transducer and activator of transcription tyrosine kinase domain c-Kit in normal cell.Notes: Ras/Erk pathway directs to activate of the proliferation genes (2016, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,unidentified,NA)
• Signal transducer and activator of transcription tyrosine kinase domain c-Kit in cancer cell.Notes: The Ras-Erk pathway, PI3K/AKT pathway, and Src-signaling pathway have been demonstrated in this schematic picture (2016, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,unidentified,NA)
• Processes responsible for the synthesis, trafficking, and degradation of membrane proteins (2016, Homo sapiens,Mus musculus)
• Molecular mechanisms of alcohol-related liver pathogenesis and therapeutic targets (2016, NA)
• Telomerase reverse transcriptase acts in a feedback loop with NFKB pathway to regulate macrophage polarization in alcoholic liver disease (2016, NA)
• Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers (2016, Homo sapiens,Candida dubliniensis)
• Signaling affecting stem cells identity and their interplay with chromatin (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Gliadin peptides pass through the epithelial barrier paracellularly or transcellularly (2016, NA)
• PI-103 and Quercetin Attenuate PI3K-AKT Signaling Pathway in T- Cell Lymphoma Exposed to Hydrogen Peroxide (2016, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Allium cepa,Homo sapiens,Mus musculus)
• ‘Atherothrombosis-associated microRNAs in Antiphospholipid syndrome and Systemic Lupus Erythematosus patients’ (2016, NA)
• Hypothesis of “The regulation of H3K27me3 on S (2016, NA)
• Differentially expressed proteins regulated cellular processes/diseases and hypothetical depiction of BPA action (2016, NA)
• Gene expression, proteome, and metabolome contrasts in young and immature tissues, assigned to the central carbon metabolism (2016, Setaria italica,Homo sapiens)
• Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response (2016, NA)
• IL-6 signaling pathways (2016, Homo sapiens,Mus musculus,Human papillomavirus type 16,Curcuma longa)
• mTOR signaling (2016, NA)
• Mitogen-activated protein kinase (MAPK) signaling pathway (2016, NA)
• Ion homeostasis (2016, NA)
• PI3K-AKT (phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT) signaling pathway (2016, NA)
• JAK-STAT (Janus kinase/signal transducers and activators of transcription) pathway (2016, NA)
• Protein kinase A (PKA) signaling pathway (2016, NA)
• Cell adhesion (2016, NA)
• Cytoskeleton remodeling and axonal transport (2016, NA)
• LINP1 regulation and role in the NHEJ DNA-repair pathway (2016, NA)
• MUC4 is negatively regulated through the Wnt/Beta-catenin pathway via the Notch effector Hath1 in colorectal cancer (2016, NA)
• Exercise Activates p53 and Negatively Regulates IGF-1 Pathway in Epidermis within a Skin Cancer Model (2016, NA)
• Molecular alterations cause metabolic switching in cancer cells and severe metabolic changes in the tumor microenvironment (2016, NA)
• Regulation of the Hippo pathway by multiple upstream signals (2016, NA)
• Multifaceted regulation of T cell responses by ROS (2016, NA)
• Thumbnail image of MAPK signalling pathway (2016, Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Armoracia rusticana,Venustaconcha ellipsiformis,Ginkgo biloba,Homo sapiens,Bos taurus)
• Main WNT/Beta-catenin pathway involved in cancer and stem cells (2016, NA)
• Molecular mechanisms underlying progesterone-enhanced breast cancer cell migration (2016, NA)
• Signaling pathways regulated by SHP-2 in the gastrointestinal tract (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Helicobacter pylori)
• Mechanism of action of PIs, immunomodulators, and HDACi.Notes: Proteasomes are intracellular structures which catabolize proteins that are marked with ubiquitin (2016, Saccharomyces cerevisiae,Diaporthe sclerotioides,Bikinia letestui,Homo sapiens,Mus musculus)
• Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity (2016, NA)
• Possible mechanism for the antagonistic effect of Lpp and RNA in innate immune stimulation in monocytes and macrophages (2016, NA)
• Overall organization of JNK signaling pathways (2016, NA)
• Structure and function of JIP1 acting within the JNK pathway (2016, NA)
• Roles of different bacterial SMases and PLases in virulence (2016, Homo sapiens)
• PI3K/Akt/mTOR signaling pathway and the existing molecular targets for therapy, which was indicated by ∆ (2016, Homo sapiens)
• Proposed regulation of HSC quiescence by paternally imprinted DMRs (2016, NA)
• Mitochondrial dysfunction in gliomas- Evasion of Apoptosis: Impaired mitochondrial function due to the genomic mutations in mtDNA leads to impaired function of electron transport chain thus enhancing generation of ROS (2016, NA)
• Pathophysiology of Diabetic neuropathy: Glucose induced osmotic stress, reactive oxygen species (ROS) and antioxidant depletion results in the formation of intense oxidative stress inside neuronal cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hypoxia‐induced changes in mitochondrial metabolism (2016, NA)
• Signaling network of drug-induced glioma differentiation (2016, Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Rattus norvegicus,Escherichia coli O157H7 str. EC10)
• Non-activated canonical Wnt signaling pathway and the drug targeted components (2016, Lareunionomyces loeiensis,Curcuma longa,Rheum rhabarbarum,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Activated canonical Wnt signaling pathway and the drug targeted components (2016, Lareunionomyces loeiensis,Curcuma longa,Rheum rhabarbarum,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Signalling pathway and targeted therapy in gastric cancer (2016, NA)
• Proposed Model of PI3KA Resistance in SGK1-Expressing CellsPIK3CA-mutant breast tumors depend on the PI3K pathway, which mainly signals through AKT (2016, NA)
• Processes involved in particle-induced pro-IL-1B expression (2016, NA)
• Members of receptor tyrosine signaling pathways that are predicted as indispensable nodes and targeted by cancer mutations, OMIM disease, viruses, or FDA-approved drugs (2016, Homo sapiens)
• Common PI3K pathway aberrations found in a variety of solid tumor types (2016, Homo sapiens)
• Common nodes of resistance to targeted therapies within the PI3K pathway (2016, Homo sapiens)
• Targeting the PI3K pathway in cancer with small-molecule inhibitors (2016, Homo sapiens)
• Selected potential Rho GTPase functional networks identified in the RNAi screen (2016, Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Equus caballus,Venustaconcha ellipsiformis,Homo sapiens)
• MYC splicing connections in cancer (2016, NA)
• Bunyavirus-induced Wnt/Beta-catenin signaling (2016, Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,Rift Valley fever virus,Myxoma virus,La Crosse virus,Uukuniemi virus,California encephalitis virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Lareunionomyces loeiensis,Matthiola incana,Chlorocebus aethiops,Mus musculus,NA,NA)
• TGFB signaling in bone (2016, NA)
• BMP signaling in bone (2016, NA)
• The HGF/Met-FOXM1 positive feedback loop (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,vectors,Human alphaherpesvirus 3)
• Adipose- and muscle-derived Wnts trigger pancreatic Beta-cell adaptation to systemic insulin resistance (2016, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Representation of the top Canonical Pathways, Functional Annotations and Upstream Regulators detected upon analysis of target genes and their co-regulated genes (2016, NA)
• Germline Nf1 gene mutation independently determines astrocyte and microglia dysfunction relative to optic glioma formation and growth (2016, Homo sapiens,Mus musculus)
• Changes in the representation of IGF-Akt pathway (2016, NA)
• Mechanism of hepatocarcinogenesis promotion via HBV-induced ROS accumulation (2016, NA)
• SRSF1's roles in transformation in breast cancer (2016, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Gallus gallus)
• Signal transduction pathway like mitogen-activated protein kinase/extracellular signal-regulated kinases signaling pathway (2016, NA)
• Molecular pathways affected by Gcm (2016, NA)
• The regulation of cell motility by the RSK-SH3P2-Myo1E axis (2016, NA)
• Classical pRb pathway demonstrates the utility of CDK inhibitors, such as palbociclib, in RB+/+ osteosarcoma (2016, Homo sapiens,Mus musculus,Betapolyomavirus macacae,NA)
• Activation of the NFKB and JAK-STAT signaling pathways are crucial for proper antiviral response (2016, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Vibrio cholerae,Porphyromonas gingivalis,Streptococcus pyogenes,Campylobacter jejuni,Borreliella burgdorferi,Lactobacillus acidophilus,Proteus mirabilis,Yersinia enterocolitica,Candidatus Arthromitus sp. SFB-mouse,Bifidobacterium adolescentis,Tannerella forsythia,Prevotella intermedia,Mycoplasmopsis fermentans,Borreliella burgdorferi B31,Metamycoplasma arthritidis,Leptospira interrogans serovar Pomona,Human gammaherpesvirus 4,Human alphaherpesvirus 1,unidentified influenza virus,Human betaherpesvirus 5,Human alphaherpesvirus 2,Human endogenous retrovirus,Mus musculus,Rattus norvegicus,Candida albicans,Phytolacca americana,Homo sapiens,gut metagenome)
• Regulation of rhein on the crosstalk of MAPK signaling pathway (2016, Candida dubliniensis,Aloe vera,Rheum palmatum,Fallopia multiflora,Aconitum carmichaelii,Senna alexandrina,Capsosiphon fulvescens,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of rhein on the crosstalk of PI3K-AKT signaling pathway (2016, Candida dubliniensis,Aloe vera,Rheum palmatum,Fallopia multiflora,Aconitum carmichaelii,Senna alexandrina,Capsosiphon fulvescens,Mus musculus,Rattus norvegicus,Homo sapiens)
• Processing of engulfed dying cells requires LC3-associated phagocytosis (LAP) and promotes an anti-inflammatory response (2016, NA)
• Antibody-mediated blockade of the PS signaling pathway in the tumor microenvironment (2016, NA)
• HGF/Met pathway (2016, NA)
• Some pathways affected by Sorafenib (2016, NA)
• TARGETING INFLAMMATION IN METABOLIC SYNDROME (2016, Mus musculus,Rattus norvegicus,Olea europaea,Helianthus annuus,Homo sapiens,Bos taurus)
• Cellular and molecular events of autophagy–lysosomal pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• TARGETING INFLAMMATION IN METABOLIC SYNDROME (2016, Mus musculus,Rattus norvegicus,Olea europaea,Helianthus annuus,Homo sapiens,Bos taurus)
• Proposed pathway model of Phd2 regulation on chondrocyte survival and differentiation (2016, Mus musculus,Dipturus trachyderma,Homo sapiens)
• Regulation of the Hippo pathway by upstream signals (2016, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Ginkgo biloba,Gynostemma pentaphyllum,Homo sapiens)
• Activation of the complement system (2016, NA)
• Transcriptome and biomineralization responses of the pearl oyster Pinctada fucata to elevated CO2 and temperature (2016, NA)
• Deletion of the RIM15 gene on the metabolic profile of a laboratory strain during alcoholic fermentation (2016, NA)
• Role of innate immunity in nonalcoholic fatty liver disease progression (2016, Homo sapiens,Mus musculus)
• Sulforaphane regulates Keap1-Nrf2-ARE signaling pathway and induces phase II metabolic enzyme expression (2016, NA)
• Schematic model depicting how ERK1/2 activity is transduced through the Shoc2 scaffold (2016, Caenorhabditis elegans,Plasmodium falciparum,Homo sapiens,Mus musculus)
• Activation and molecular crosstalk amongst signaling pathways (2016, NA)
• PhenomeExpress analysis (2016, Bos taurus,Canis lupus familiaris,Ovis aries,Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Network motifs that are coordinately regulated by the miR-17–92 cluster (2016, NA)
• Gene–gene network category and pharmacological category (2016, Homo sapiens,Mus musculus)
• Omics datasets containing multiple time points can be presented in the form of omics popups on individual full-detail pathway diagrams (2016, NA)
• Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate (2016, Oikopleura dioica)
• The mechanisms underlying contributions of YAP/TAZ/Beta-catenin to the spinal central sensitization after nerve injury and regulation of dCTB on YAP/TAZ/Beta-catenin and Hippo signaling pathways (2016, NA)
• New pathway collage diagram combines multiple pathway diagrams for a selected set of pathways (2016, NA)
• ‘Wnt Signaling pathway’ from KEGG () (ID hsa04310) (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Human betaherpesvirus 5)
• Coelimination and Survival in Gene Network Evolution: Dismantling the RA-Signaling in a Chordate (2016, Saccharomyces cerevisiae,Oikopleura dioica,Homo sapiens)
• HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling (2016, NA)
• Linear in silico activation pathway of CD8+ T cells (2016, unidentified influenza virus,H1N1 subtype,Homo sapiens,Mus musculus,Mycobacterium tuberculosis)
• Showing the TRAIL signalling pathway (2016, NA)
• Canonical Wnt signalling pathway (2016, NA)
• Model depicting proangiogenic lactate signaling in cancer (2016, NA)
• Example of the allosteric network ‘Calcium signaling pathway’ (2016, Homo sapiens,Mus musculus,Bos taurus,Helicobacter pylori)
• RNF8 and RNF168 promote the accumulation of 53BP1 and RAP80 at DSB sites (2016, Homo sapiens,Mus musculus)
• Cholesterol biosynthetic/protein prenylation pathway (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases (2016, Saccharomyces cerevisiae,Glycine max,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Colorectal tumorigenesis in proximal/whole-colon and distal serrated polyposis (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• IGF-1R/AKT pathway determines cell fate in response to p53 (2016, Homo sapiens,Human immunodeficiency virus 1,Bikinia letestui)
• IGF-1R/AKT pathway determines cell fate in response to p53 (2016, Homo sapiens,Human immunodeficiency virus 1,Bikinia letestui)
• IGF-1R/AKT pathway determines cell fate in response to p53 (2016, Homo sapiens,Human immunodeficiency virus 1,Bikinia letestui)
• IGF-1R/AKT pathway determines cell fate in response to p53 (2016, Homo sapiens,Human immunodeficiency virus 1,Bikinia letestui)
• IGF-1R/AKT pathway determines cell fate in response to p53 (2016, Homo sapiens,Human immunodeficiency virus 1,Bikinia letestui)
• Conceivable mechanisms of resistance to abiraterone and enzalutamide (2016, NA)
• Wnt5a signals to inactivate Orai1 (2016, Homo sapiens,Mus musculus,Sesamum indicum)
• Canonical and non-canonical Wnt pathways have differing effects in cancer (2016, Homo sapiens,Mus musculus,Sesamum indicum)
• N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications (2016, Mus musculus,Rattus norvegicus,Phaseolus vulgaris,Sambucus nigra,Homo sapiens,Mouse mammary tumor virus,Triportheus paranensis)
• N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications (2016, Mus musculus,Rattus norvegicus,Phaseolus vulgaris,Sambucus nigra,Homo sapiens,Mouse mammary tumor virus,Triportheus paranensis)
• Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1A via the PI3K/AKT/mTOR pathway (2016, NA)
• Adipocytes WNT5a mediated dedifferentiation: a possible target in pancreatic cancer microenvironment (2016, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Quantification of mutant alleles in circulating tumor DNA can predict survival in lung cancer (2016, NA)
• Effect of A (2016, NA)
• Effect of A (2016, NA)
• Dynamically alternative pathway network (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cellular and molecular interactions between CLL cells and the tissue microenvironment (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Helicobacter pylori)
• Transcriptional activation of muscle atrophy promotes cardiac muscle remodeling during mammalian hibernation (2016, Mus musculus,Cricetus cricetus,Ictidomys tridecemlineatus,Callospermophilus lateralis,Urocitellus undulatus,Oryctolagus cuniculus,Ursus arctos,Homo sapiens,Lareunionomyces loeiensis)
• Collagen upregulates MMP-14 through activation of the TGFB/TBRI/Smad3/Snail pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human gammaherpesvirus 8)
• mGluR5 and CB1 cooperatively activate cell signaling pathways to promote neuroprotection (2016, NA)
• 5 nM PhIP activates STAT3-mediated transcriptional regulation (2016, NA)
• GO biological process and KEGG pathway enrichment analyses of the differentially modulated proteins at 6 and/ or 12 h of treatment with A233 peptide (2016, NA)
• Sonic hedgehog (SHH) signaling pathway (2016, NA)
• Low-density LRP1-mediated cell signaling pathways (2016, Homo sapiens,Mus musculus)
• HIV-associated disruption of tight junctions in initial HIV entry and systemic HIV/AIDS disease (2016, Human immunodeficiency virus)
• Tarp protein mediated signaling pathways implicated in chlamydial entry and development (2016, NA)
• Action of Rasd1 in cAMP-dependent gene regulation (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Sesamum indicum,Homo sapiens,Adeno-associated virus,NA)
• Major hub gene BrPLA2-ALPHA-centered gene coexpression network using probes with at least one (after correction) (2016, NA)
• IL-21 signaling pathway (2016, NA)
• B-cell activation and differentiation (2016, NA)
• Therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools (2016, Mus musculus,Cavia porcellus,Homo sapiens,Human immunodeficiency virus 1,Sequoia sempervirens)
• Immunoglobulin (Ig) production (2016, NA)
• Electrophoretic mobility shift assay (EMSA) and the predicted model for the process of melanin biosynthesis (2016, NA)
• The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Armoracia rusticana,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus)
• Summary diagram illustrates a hypothesis for how ZSTK474 exerts its effects on ischemic reperfusion injury (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Panax ginseng)
• Sealing pathway schematic for multiple proteins and pathways involved in vesicle mediated repair of plasmalemmal damageSee text for references (2016, NA)
• “Inhibition of MMPs” signaling pathway at 1, 4, 7, and 14 days after nerve crush injury.Differentially expressed genes are shown in red (up-regulated) and green (downregulated) (2016, NA)
• Hypoxia and signaling mediators (2016, NA)
• Network of reported candidate genes associated with GTS (2016, NA)
• Plasticity of Arterial and Venous Endothelial Cell Identity – Some Nerve! (2016, NA)
• mf regulated mTOR signaling pathway in human DC (2016, NA)
• Impact of sleep deprivation on hippocampal spine dynamics (2016, NA)
• TLR signal transduction pathways (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Drosophila melanogaster,Candida dubliniensis,Cannabis sativa,Cryptosporidium parvum,Homo sapiens,Canis lupus familiaris,unidentified influenza virus)
• Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures (2016, Homo sapiens,Mus musculus,clinical samples)
• Effects of silica NPs on Wnt signaling (2016, NA)
• Upstream regulatory analysis of weight-loss–associated genes identified strong C/EBPA activation (2016, NA)
• The insulin signalling pathway with years of discovery of the key elements in the pathway (2016, NA)
• Promoter-specific DNA methylation of genes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) mitogen-activated protein kinase (MAPK) signaling pathway (2016, NA)
• Possible mechanism of maternal chromium restriction on offspring (2016, NA)
• Wedelolactone enhances osteoblastogenesis by regulating Wnt/Beta-catenin signaling pathway but suppresses osteoclastogenesis by NFKB/c-fos/NFATc1 pathway (2016, NA)
• Canonical Wnt signaling pathway (reproduced with permission from) (2016, Mus musculus,Homo sapiens)
• Model describing the mechanism of TLRs in cancer therapy (2016, NA)
• Main components of innate immune system in epidermis and their role in atopic dermatitis (AD) (2016, Staphylococcus aureus,Staphylococcus epidermidis,Homo sapiens)
• RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism (2016, NA)
• Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin (2016, NA)
• Schematic diagram illustrating the UPR signal transduction pathway (2016, NA)
• Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells (2016, NA)
• Action and impact of sustained Gq-protein signaling on striatal circuitry (2016, Mus musculus,Homo sapiens)
• GM-CSF and IL-6 signaling (2016, NA)
• Association of the Wnt pathway with stress responses and aging (2016, Drosophila melanogaster,Caenorhabditis elegans,Amphimedon queenslandica,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Sinularin-induced apoptosis in the AGS and NCI-N87 gastric cancer cells (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Caenorhabditis elegans,Sinularia flexibilis,Homo sapiens,Mus musculus,Armoracia rusticana,Helicobacter pylori,NA)
• Proposed model illustrating how KLHL21 modulates the NFKB signaling pathway via targeting IKKB (2016, NA)
• Roles of mTOR complexes in the kidney: implications for renal disease and transplantation (2016, Homo sapiens)
• FGFR signalling and model for the role of cholesterol biosynthesis in the maintenance of lysosomal membrane integrity under CQ- and BafA1-induced stress (2016, Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Bos taurus,Human immunodeficiency virus 1)
• Potential role of a melanocyte antigen within the complex psoriatic inflammatory pathway (2016, Homo sapiens,Mus musculus,Gallus gallus)
• Beneficial effects of increased-based therapy (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Human immunodeficiency virus 1)
• Proposed signal pathway activated by HMDB in HeLa cervical cancer cells (2016, NA)
• Diagram of LPS-induced TLR4 signaling (2016, NA)
• Kallistatin inhibits oxidative stress, inflammation and apoptosis through inhibiting TNFA signaling and promotes NO production through eNOS stimulation (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Lareunionomyces loeiensis)
• Kallistatin inhibits angiogenesis and inflammation through blocking VEGF signaling and NADPH oxidase activity (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Lareunionomyces loeiensis)
• Adaptive and pro-apoptotic pathways of the UPR (2016, NA)
• Kallistatin inhibits Wnt canonical pathway induced angiogenesis and inflammation (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Lareunionomyces loeiensis)
• Regulated necrosis: disease relevance and therapeutic opportunities (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Murid betaherpesvirus 1,Taxila haquinus)
• Sphingolipids as targets for treatment of fungal infections (2016, NA)
• Androgen receptor (AR) signaling pathway (2016, NA)
• Simplified representation of canonical and non-canonical Hedgehog(HH) signaling (2016, NA)
• Outline of the PKC regulation of COX-2 and IL-8 production and the potential acting points of ghrelin (GHRP-2) in ovarian granulosa cells (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Human papillomavirus type 16,NA)
• Efficient Reconstruction of Predictive Consensus Metabolic Network Models (2016, Escherichia coli,Mycobacterium tuberculosis,Bacillus subtilis,Pseudomonas putida,Escherichia coli str. K-12 substr. MG1655,Mycobacterium tuberculosis H37Rv,Pseudomonas putida KT2440,Saccharomyces cerevisiae,Neurospora crassa,Homo sapiens,Plasmodium falciparum)
• MCD genes and cytoskeletal regulatory pathways (2016, NA)
• The proposed cellular signaling pathways regulating DSM excitability and contractility (2016, Homo sapiens)
• Regulation of TLR4 signalling by the ubiquitin-proteasome system (2016, NA)
• Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes (2016, NA)
• Insulin signaling pathway (2016, NA)
• Domain organization of the CrRLK1L proteins (2016, Arabidopsis thaliana,Oryza sativa,Solanum lycopersicum,Embryophyta,PX clade,Magnoliopsida,Chlamydomonas reinhardtii,Ginkgo biloba,Catharanthus roseus,Physcomitrium patens,Tracheophyta,Lotus japonicus,Picea abies,Bryophyta,Coniferophyta,Spermatophyta,Marchantia polymorpha,Selaginella moellendorffii,Volvox carteri,Amborella trichopoda,Ostreococcus sp. lucimarinus,Micromonas pusilla,Ceratophyllum demersum,Coccomyxa subellipsoidea,Cycadophyta,Closterium ehrenbergii,Closterium peracerosum-strigosum-littorale complex,Nitella axillaris,Xenopus laevis,Parvimonas sp.,Homo sapiens)
• Calcineurin/NFAT signaling pathway (2016, NA)
• Cross talk between multiple signaling pathways involved in tumor progression and resistance (2016, NA)
• Overlapping RAS/MAPK and PIK3CA/AKT/mTOR signaling pathways and potential therapeutic targets (2016, Homo sapiens)
• Thermodynamic and kinetic framework of P4-P6 folding (5 mM MgCl2, 100 mM KCl, 23 °C) (2016, NA)
• Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms (2016, NA)
• Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems (2016, NA)
• Ingenuity pathways analysis (IPA) of ASS234 (5 μM) treatment (2016, NA)
• IL-23/T17 pathogenic axis is an important therapeutic target in psoriasis (2016, Homo sapiens,Mus musculus,Erruca cardinalis)
• FGF21 Signaling Network in Adipocytes (2016, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways (2016, NA)
• Working model of consequences of PREX2 truncating mutations (2016, NA)
• Different apoptotic pathways are modulated by PEDF (2016, NA)
• BRAF mutations on tumor cell survival and the tumor microenvironment (2016, NA)
• Schematic summary of general roles of RAS-RAF-MEK pathway in protecting dendritic atrophy caused by dynein malfunction or mitochondrial dysfunction (2016, NA)
• Main mediators of NVC responses to distinct cortical afferent pathways (2016, Homo sapiens)
• Cortical neuronal networks recruited by different afferent inputs (2016, Homo sapiens)
• Cyclic AMP-dependent signaling pathway (2016, NA)
• Aberrations in the cyclic AMP-dependent signaling pathway in adrenocortical tumors (2016, NA)
• IL-10 and integrin signaling pathways are associated with head and neck cancer progression (2016, NA)
• CYLD-associated signaling pathways (2016, Homo sapiens,Mus musculus,Human papillomavirus,unidentified)
• Role of CDKN2C Copy Number in Sporadic Medullary Thyroid Carcinoma (2016, NA)
• Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride (2016, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Mouse mammary tumor virus,H5N1 subtype,Myodes glareolus,Homo sapiens,Oryctolagus cuniculus)
• Partial picture of) the SREBP regulatory network (2016, NA)
• Schematic showing proposed mechanism of ECM synthesis following CDH11 engagement (2016, NA)
• Threshold-setting by noise canceling and overriding pathways in 1-MeAde signaling (2016, NA)
• Core Hippo pathway (2016, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Current view on T cell NNCS in regulation of immune function (2016, NA)
• MTOR pathway (2016, Homo sapiens)
• Metabolism on Foxp3 expression and the generation of Treg cells (2016, NA)
• Regulation of molecules in the NMDAR signaling pathway on learning and memory (2016, NA)
• The Shh signaling pathway (2016, NA)
• IL-10-producing B cells induced by TRAPs (2016, Homo sapiens,Mus musculus)
• Stimulatory effects of the degradation products from Mg-Ca-Sr alloy on the osteogenesis through regulating ERK signaling pathway (2016, Armoracia rusticana,Allium cepa,Ginkgo biloba,Homo sapiens,Mus musculus,Bos taurus)
• SPATA2 – Keeping the TNF signal short and sweet (2016, NA)
• Potential impact of bone tissue engineering in the clinic (2016, NA)
• Potential impact of bone tissue engineering in the clinic (2016, NA)
• MAPK/MSK1/Histone H3 pathway on target gene transcription (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Working model of PRL-3 involvement in TNF-R1 pleiotropy (2016, Homo sapiens,Mus musculus,Bos taurus)
• Diagram summarizing the proposed mechanism by which MACC1 drives resistance to trastuzumab (2016, NA)
• Model cell illustrates the Gq-mER signaling pathway in hypothalamic PVN CRH neurons that mediates the modulatory effect of E2 (or STX) on the M-current and on mEPSCs (1) (2016, NA)
• Transforming growth factor B (TGFB) receptors and signal transducers (2016, NA)
• MicroRNA (miRNA) biogenesis pathway and its regulation by Smad proteins (2016, NA)
• Monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus)
• Beyond evidence-based data: scientific rationale and tumor behavior to drive sequential and personalized therapeutic strategies for the treatment of metastatic renal cell carcinoma (2016, Homo sapiens)
• Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach (2016, unidentified influenza virus,Orthomyxoviridae,Human rhinovirus sp.,Influenza A virus H3N2,H9N2 subtype,H5N2 subtype,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Streptococcus pneumoniae,NA)
• KEGG in Graphviz view of T-cell receptor signaling pathways on a canonical signaling pathway with gene methylation chip data (2016, Homo sapiens,Mus musculus)
• KEGG in Graphviz view of Jak–STAT signaling pathways on a canonical signaling pathway with gene methylation chip data (2016, Homo sapiens,Mus musculus)
• Genes associated with paclitaxel (A) and gemcitabine (B) mechanism of action (direct targets, metabolizing enzymes), genes previously associated with resistance, and stable genes in the biological pathways targets (2016, NA)
• IL-10 Anti-inflammatory Signaling Pathway is enriched for putative differentially expressed genes (Progressors vs NonProgressors Enrichment False Discovery Rate adjusted P-value = 0.0287) Figure is a stylized representation of the Biocarta pathway (2016, NA)
• The Wnt-5a effects at the postsynaptic region (2016, NA)
• 3′-hydroxy-3,4,5,4′-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s disease (2016, Homo sapiens,Gorilla gorilla,Mus musculus,Bikinia letestui)
• Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Escherichia coli,vectors)
• Insulin-like growth factor 1 regulates growth of endometrial carcinoma through PI3k signaling pathway (2016, Homo sapiens)
• NFKB pathway genes with correlation to HOXA1 expression in breast cancer (2016, NA)
• Wnt pathway regulation of intestinal stem cells (2016, NA)
• Wnt pathway regulation of intestinal stem cells (2016, NA)
• Adaptive UPR in Parkinson׳s disease (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Nicotiana tabacum,prion)
• Summary of interactions involved in Wnt signaling cascades inferred to regulate NC biological functions (2016, NA)
• MET signaling pathway in IPF (2016, Homo sapiens,Mus musculus,Helicobacter pylori,Calloplesiops altivelis,Hippospongia communis,Boehmeria nivea)
• Impact of heterologous 2,3-BDO metabolic pathway engineering and oxygen levels on native central carbon metabolism in Z (2016, NA)
• Sensing of HMPV by different PRRs and modulation of the IFN response by viral proteins (2016, NA)
• Representation of Canonical Wnt/Beta-catenin pathway (2016, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Staphylococcus aureus,Lareunionomyces loeiensis,Mouse mammary tumor virus,NA)
• Insulin receptor signal transduction via PI3K/PKB pathway (2016, NA)
• Chemokine signaling pathway (2016, NA)
• Inhibition mechanism of antioxidants, cyclosporine A (CsA) and SB203580 (2016, NA)
• Endothelial Mechanosignaling: Does One Sensor Fit All? (2016, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Shear-Sensitive Genes in Aortic Valve Endothelium (2016, NA)
• Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine (2016, herbal medicine,Zingiber officinale,Wurfbainia villosa,Cyperus rotundus,Albizia julibrissin,Lindera aggregata,Cissus quadrangularis,Lilium brownii,Lilium brownii var. viridulum,Helicobacter pylori,Streptomyces griseus,Streptomyces microflavus,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,unidentified)
• Canonical wingless/int-1signaling pathway (2016, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,Hepatitis B virus,NA)
• Non-canonical wingless/int-1 signaling pathway (2016, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,Hepatitis B virus,NA)
• Regulation of wingless/int-1 signaling by crosstalk in hepatocellular carcinoma (2016, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,Hepatitis B virus,NA)
• Physiological effects of ROS on synaptic plasticity (2016, Homo sapiens)
• Pathway map of quantitative comparisons of metabolic proteins in DLD-1 cell lines (2016, NA)
• Pathway map of quantitative comparisons of metabolic proteins in RKO cell lines (2016, NA)
• Wnt/Beta-catenin upregulation in CRC and PDAC (2016, NA)
• Proposed model for plasma long‐chain acylcarnitine contributions to the heart failure phenotype (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca arctoides)
• Restoring immune tolerance in neuromyelitis optica (2016, NA)
• Schematic illustration depicting Ca2+/CaN-dependent NFATc4 activity on the modulation of neuritin-induced Kv4.2 expression and the subsequent increase in IA channel density (2016, NA)
• Na+/K+-ATPase pumping and signaling functions in cardiomyocytes (Liu et al., , ; Wu et al., ) (2016, NA)
• Signaling pathway by which TGFB1 increases DNMT1 and DNMT3a (2016, NA)
• Mechanisms by which mitochondrial DNA activates innate immunity (2016, Homo sapiens,Mus musculus)
• Visualizations of Wnt pathway reconstructions (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• PATHLINKER algorithm (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Predicted changes in the flux distributions as computed with FVA between pH 7.5 and 6.5 involving protons (2016, NA)
• Proposed model for the impact of CCL2 on HDL internalization and cholesterol efflux and regulatory mechanisms in HCAECs (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• The signaling pathway by which FSH, via PKA, regulates the PI3K and ERK pathways in GCs (2016, NA)
• Different strategies of metabolic regulation in cyanobacteria: from transcriptional to biochemical control (2016, Escherichia coli,Synechocystis sp. PCC 6803,Synechocystis sp.,Synechococcus elongatus PCC 6301,Synechococcus elongatus PCC 7942 FACHB-805)
• CaMKII-Mediated CREB Phosphorylation Is Involved in Ca2+-Induced BDNF mRNA Transcription and Neurite Outgrowth Promoted by Electrical Stimulation (2016, NA)
• GLP-1R signaling in GnRH neurons and its proposed action on presynaptic GABA release (2016, NA)
• Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway (2016, Armoracia rusticana,Panax ginseng,Astragalus oleifolius,Mus musculus,Rattus norvegicus,Bos taurus,Equus asinus,Homo sapiens,Hepatitis B virus,Mycobacterium tuberculosis H37Ra)
• Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitination (2016, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens)
• Mitogen-activated protein kinase (MAPK) signaling pathways (2016, NA)
• Wnt signaling pathways regulate gene expression and cell movements (2016, NA)
• Schematic model was proposed to describe the promotion of cardiac differentiation of BASCs by CNTs through the B1 integrin-dependent TGFB1 signaling pathway.Notes: CNTs activated B1-integrin residing in the cytomembrane to release the active TGFB1 (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions (2016, Human immunodeficiency virus 1,Hepatitis B virus,Dengue virus,Vaccinia virus,Measles morbillivirus,Coxsackievirus B3,Dengue virus type 3,Homo sapiens,Sus scrofa,Mycobacterium tuberculosis,clinical samples,NA)
• De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin (2016, NA)
• Selected metabolic pathways involved in vasoconstriction and vasodilation where there is evidence for the action of (poly)phenols (2016, NA)
• Signaling pathways involved in keratinocyte growth and differentiation that are perturbed by SbIII and AsIII (2016, Homo sapiens,Rattus norvegicus,Bos taurus,Oryza sativa)
• Genetic Alterations of D-Catenin/NPRAP/Neurojungin (CTNND2): Functional Implications in Complex Human Diseases (2016, NA)
• Negative regulators of Toll-like receptor signaling (2016, NA)
• Diagrammatic summary of the principal ways by which the Unfolded Protein Response pathway may interact with the mTOR/AKT pathway to modulate protein synthesis within the placenta (2016, NA)
• Interaction of stromal derived factor-1 (SDF-1), Hmox1, and endothelial nitric oxide synthase (eNOS) in response to vascular injury (2016, NA)
• Schematic showing the mechanisms by which CO and bilirubin affect VSMC proliferation (2016, NA)
• Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways (2016, Escherichia coli,Pseudomonas putida S16,Homo sapiens,Venustaconcha ellipsiformis,Aepyceros melampus)
• An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population (2016, NA)
• Regulating signal pathway related to gastric lipase (LIPF) and diacylglycerol kinase A (DGKA) in gastric cancer (GC) (2016, NA)
• Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis (2016, NA)
• TNF-Alpha-activated canonical nuclear factor kappa-light-chain-enhancer of activated B cells (NFKB) signaling pathway (2016, NA)
• Non-canonical NFKB signaling pathway (2016, NA)
• Ingenuity Pathways Analysis of the identified methylated targets (2016, NA)
• Simplified model of the canonical Wnt pathway and inhibitors (2016, NA)
• Mechanism for HKa-induced endothelial apoptosis and inhibition of angiogenesis (2016, NA)
• Network-Based Data Integration Approach to Support Drug Repurposing and Multi-Target Therapies in Triple Negative Breast Cancer (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Erebia meta)
• The role of FOXO3a in GC-mediated inhibition of pro-inflammatory responses (2016, Homo sapiens,Mus musculus)
• Schematic showing the sources of NADPH in the mitochondrial matrix (2016, NA)
• Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Byasa polyeuctes)
• Complement activation and immune regulation (2016, NA)
• PI3K–AKT–mTOR pathway and drug targets (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Recognition of C. albicans by pattern recognition receptors (2016, NA)
• Possible antioxidant response of flavonoids compounds combined with Nrf2 pathway (2016, Ugni molinae,Homo sapiens)
• Oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway (2016, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Capra hircus,Escherichia coli 53A,Escherichia coli PA5,Homo sapiens,Lareunionomyces loeiensis,NA)
• PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development (2016, Bos taurus,Capra hircus,Solanum lycopersicum,Sesamum indicum,Homo sapiens,Mus musculus)
• Fanconi anemia (FA) DNA damage repair pathway (2016, Homo sapiens,Rattus norvegicus)
• Hypothesized model showing the effect of GPEP on lipogenesis in adipocytes (2016, Mus musculus,Homo sapiens)
• Proposed molecular model of circadian rhythms in S (2016, NA)
• Induction of triglyceride accumulation and mitochondrial maintenance in muscle cells by lactate (2016, NA)
• Red nodes indicate the query proteins and the proteins present in the dotted circles, VTN, PRKACA, RELA, EP300, AKT1, EIF2C1, are the common proteins associated with the query proteins (2016, NA)
• NOD2 senses MDP and elicits immune responses (2016, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Clostridioides difficile,Enterococcus faecalis,Bacteroides fragilis,Faecalibacterium prausnitzii,Clostridioides difficile CD3,Helicobacter hepaticus,Phocaeicola vulgatus,Clostridioides difficile CD17,gut metagenome,human metagenome,Homo sapiens,Mus musculus,Sus scrofa)
• Central carbon metabolism and other relevant metabolic pathways identified in SAR11 genomes (2016, NA)
• SK1/S1P signalling pathway (2016, NA)
• Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters (2016, NA)
• Altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters (2016, NA)
• NFKB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression (2016, NA)
• cRGD inhibits vasculogenic mimicry formation by down-regulating uPA expression and reducing EMT in ovarian cancer (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Gallus gallus,Human immunodeficiency virus 1)
• Multifunctional targeting vinorelbine plus tetrandrine liposomes for treating brain glioma along with eliminating glioma stem cells (2016, NA)
• Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer (2016, NA)
• Major metabolic pathways anticipated to participate in spore germination process in N (2016, NA)
• The regulation of lysosomal biogenesis and autophagy by cathepsin B in response to infection with F (2016, NA)
• Diagram showing the regulation of dopaminergic neuronal differentiation of human neural stem cells (hNSCs) (2016, Homo sapiens)
• Apical signals inhibit nuclear YAP localisation (2016, NA)
• Current knowledge on the cell type/context-dependent regulation of NFKB signaling by Wnt/Beta-catenin pathway (2016, Salmonella enterica subsp. enterica serovar Typhimurium,Porphyromonas gingivalis,Homo sapiens,Mus musculus,Porcine reproductive and respiratory syndrome virus,NA)
• Current knowledge on the cell type/context-dependent regulation of Wnt/Beta-catenin signaling by NFKB pathway (2016, Salmonella enterica subsp. enterica serovar Typhimurium,Porphyromonas gingivalis,Homo sapiens,Mus musculus,Porcine reproductive and respiratory syndrome virus,NA)
• Regulation of connexin- and pannexin-based channels by cytokines released from activated microglia (2016, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Staphylococcus aureus,Human immunodeficiency virus)
• Notch signalling pathway (2016, NA)
• Emerging role of mTOR in the response to cancer therapeutics (2016, NA)
• Vimentin, a Novel NFKB Regulator, Is Required for Meningitic Escherichia coli K1-Induced Pathogen Invasion and PMN Transmigration across the Blood-Brain Barrier (2016, NA)
• Glycolysis inhibition by accumulation of fructose-1,6-bisphosphate and dihydroxyacetone phosphate (2016, NA)
• Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection (2016, NA)
• An apoptotic cell death induced by M (2016, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycoplasmoides genitalium,Mycobacterium tuberculosis variant bovis BCG str. China,Mycoplasmopsis arginini,Mycoplasma mycoides subsp. mycoides,Mesomycoplasma ovipneumoniae,Malacoplasma iowae,Mycoplasma imitans,Mesomycoplasma ovipneumoniae SC01,Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Mustela putorius furo,Mus musculus,Rattus norvegicus,Gallus gallus,Perdix perdix,Homo sapiens)
• KEGG pathway analysis of the validated miRNAs (2016, NA)
• Schematic presentation of the N-linked core oligosaccharide structure (2016, NA)
• Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer (2016, NA)
• Global Phosphoproteomic Analysis Reveals the Involvement of Phosphorylation in Aflatoxins Biosynthesis in the Pathogenic Fungus Aspergillus flavus (2016, NA)
• Proposed mechanistic scheme of CA4 suppressing the Wnt signalling pathway in colorectal cancer (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,clinical samples,NA)
• CXCL3-induced signaling pathway in adipocytes (2016, Mus musculus,Homo sapiens)
• Fate of palmitate in hepatocytes (2016, NA)
• Schematic overview of the intrinsic and extrinsic arms of apoptotic signaling (2016, NA)
• Schematic overview of the molecular pathways involved in necroptosis (2016, NA)
• Illustration showing the mechanism by which NDRG1 mediates activation of the Wnt signaling pathway (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Mouse mammary tumor virus,Punica granatum)
• HumanCyc MAP kinase cascade, a signaling pathway diagram (2016, NA)
• The IMD pathway and its regulation by Die and WntD (2016, NA)
• Autophagy pathway (2016, Homo sapiens)
• Drosophila JNK pathway (2016, Drosophila melanogaster,Homo sapiens)
• Molecular mechanisms contributing to liver steatosis following hepatitis B virus infection (2016, NA)
• Proposed model for how mTORC1 activity controls pro-IL-1B expression (2016, NA)
• The NLRP3 inflammasome by the ubiquitin system (2016, NA)
• Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light (2016, NA)
• Hypothetical mechanistic network derived from predicted upstream regulators for genes found to be differentially expression in chondrocytes in transition from monolayer to alginate bead cultures (redifferentiation) (2016, NA)
• Sanguisorba officinalis L synergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway (2016, Sanguisorba officinalis,Homo sapiens)
• A glutamatergic synapse and the molecular circadian clockwork (2016, NA)
• The gSkM transcriptome for the comparison of HFD-ED and HFD-corn oil fed mice (2016, NA)
• Apoptosis signaling pathways induced by icariin and icariside II (2016, NA)
• Signaling pathways in EGF-induced AREG mRNA expression (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human papillomavirus,Nymphalis l-album)
• ZnO NPs pathways and effects in kidney cells (2016, NA)
• Hypothetic mechanism of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) progression (2016, Saccharomyces cerevisiae,Silybum marianum,Haematococcus lacustris,Citrus unshiu,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Brief comparison of NAFLD/NASH prevention and therapy between astaxanthin and vitamin E (2016, Saccharomyces cerevisiae,Silybum marianum,Haematococcus lacustris,Citrus unshiu,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• HCoVs on ER stress response (2016, NA)
• HCoV viral proteins on innate immunity (2016, NA)
• Activation of apoptosis by HCoVs (2016, NA)
• RAS pathway is prognostic in breast cancer (2016, Homo sapiens,Mus musculus,NA)
• Pin1 has biphasic effects on insulin signaling (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Hyperinsulinemia on the tumor cell microenvironment and intracellular signaling that contribute to tumor growth and progression (2016, Homo sapiens)
• Pin1 regulates multiple signal transductions in metabolic organs (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• mTOR Signaling Pathway (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Trigonella foenum-graecum,Homo sapiens)
• UPR mechanism (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Caenorhabditis elegans,Enterovirus A71)
• Dock3 signalling pathways in optic nerve regeneration (2016, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Cricetus cricetus,teleost fish,Homo sapiens,Sus scrofa,Adeno-associated virus)
• In response to various stressors, c-Jun N-terminal kinase (JNK) is activated and phosphorylates c-Jun, which increases the activity of activating protein-1 (AP-1) (2016, NA)
• The Fas–FasL pathway (2016, NA)
• Flux map of central carbon metabolism for free-living R (2016, Pisum sativum,Rhizobium leguminosarum)
• Proposed model for Leishmania donovani-mediated host TLR2 downstream signaling (2016, Leishmania donovani)
• IGF-1R downstream signaling cascades (2016, NA)
• Molecular pathways associated with inflammatory bowel disease (2016, Homo sapiens)
• The Notch pathway in ovarian (A) clear cell carcinoma ES2 and (B) serous carcinoma OVCAR3 cells following exposure to vorinostat (2016, NA)
• Proposed mechanism by which V8 induces apoptotic cell death in human multiple myeloma RPMI 8226 cells (2016, Homo sapiens)
• TLR signaling overview (2016, NA)
• Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells (2016, Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis,Cowpea mosaic virus)
• DNA-damage response pathway-network (2016, NA)
• Cardiovascular Disease Chemogenomics Knowledgebase-guided Target Identification and Drug Synergy Mechanism Study of an Herbal Formula (2016, Zingiber officinale,Glycyrrhiza uralensis,Homo sapiens)
• Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells (2016, NA)
• Toll-like receptor 4 (TLR4) signaling pathway in porcine intestinal epithelial (PIE) cells by acidic (APS) and neutral (NPS) exopolysaccharides produced by Lactobacillus plantarum N14 and Lactobacillus delbrueckii TUA4408L (2016, NA)
• Unravelling molecular mechanisms from floral initiation to lipid biosynthesis in a promising biofuel tree species, Pongamia pinnata using transcriptome analysis (2016, NA)
• Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research (2016, NA)
• Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research (2016, NA)
• This schematic diagram illustrates the mechanisms by which activated GLP-1R elevate repair of oxidative DNA damage and increase neuronal survival (2016, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus,Calloplesiops altivelis)
• The signaling pathway involved in 4-1BB (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Venustaconcha ellipsiformis)
• Major regulatory pathways involved in the regulation of Runx2, a chief transcriptional regulator of osteogenesis (2016, NA)
• Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (Bubalus Bubalis) (2016, NA)
• Illustration of role of differentially regulated proteins involved in different pathways in rice for sustaining during drought stress (2016, NA)
• Deconstructing the Complexity of TGFB Signaling in Hematopoietic Stem Cells: Quiescence and Beyond (2016, NA)
• Possible adverse effects of obesity on osteoblasts (2016, Homo sapiens)
• Possible adverse effects of obesity on osteoclast (2016, Homo sapiens)
• Possible antagonistic effects of obesity on myocyte signaling to accelerate muscle atrophy (2016, Homo sapiens)
• Proposed mechanism of mechanical stretch-induced VSMC hypertrophy demonstrates that the RhoA/ROCK pathway activation, calcineurin activation, NFAT nuclear translocation, and leptin synthesis are involved in this process (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Activation of NFKB and STAT signaling pathway (2016, NA)
• Patents and clinical trials involving the Wnt signaling pathway (2016, NA)
• IFN signalling pathways induced by IFNA/B and IFNG (see text for details) (2016, NA)
• Leptin and jak-stat in cancer (2016, NA)
• Integrative transcriptomic meta-analysis of Parkinson’s disease and depression identifies NAMPT as a potential blood biomarker for de novo Parkinson’s disease (2016, NA)
• CD95-mediated cell migration occurs through a Bcl-2/BclxL/VDAC1/MCU-driven mitochondrial calcium loading (2016, NA)
• CB1 cannabinoid receptor signaling and regulation of neural stem/progenitor cell proliferation (2016, NA)
• ERK signaling pathway (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Candida pruni nom. inval.,Homo sapiens,Molva molva)
• Pathway interaction network of targets of apoptomiRs in breast cancer (2016, Homo sapiens,Mus musculus,Caenorhabditis elegans,Coturnix coturnix)
• Cell polarity signaling in the plasticity of cancer cell invasiveness (2016, NA)
• Cell polarity signaling in the plasticity of cancer cell invasiveness (2016, NA)
• Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress (2016, NA)
• Dissecting dysfunctional crosstalk pathways regulated by miRNAs during glioma progression (2016, Homo sapiens,Diaporthe sclerotioides)
• FMN alleviates hypoxia-induced retinal angiogenesis through suppression of the HIF-1A/VEGF signaling pathway.Abbreviations: FMN, formononetin; NV, neovascularization (2016, Astragalus membranaceus,Homo sapiens)
• Schematic overview of the Hippo signaling pathway (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Macrostomum lignano,Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Regulation of the Hippo signaling pathway in mammalian cells (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Macrostomum lignano,Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• A, The canonical Wnt/Beta-catenin pathway and additional branches downstream of Axin/GSK-3 (2016, NA)
• Visual representation of the network generated by Ingenuity Pathway Analysis (IPA) (2016, NA)
• AGR2 signaling pathway (2016, Homo sapiens)
• Proposed mechanism of action by the combination of VCP inhibitors and ER stress‐prolonging agent Salubrinal (2016, NA)
• Pathways leading to lignin and heteroxylan in maize pericarp at stage R3 (2016, Arabidopsis thaliana,Armoracia rusticana,Nicotiana tabacum,Oryza sativa,Zea mays,Triticum aestivum,Sorghum bicolor,eudicotyledons,Beta vulgaris subsp. vulgaris,Brachypodium distachyon,Lolium arundinaceum,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Triportheus paranensis)
• Targeted proteomic approach in prostatic tissue: a panel of potential biomarkers for cancer detection (2016, Saccharomyces cerevisiae,Escherichia coli,Olea europaea,Sequoia sempervirens,Fragaria x ananassa,Escherichia coli 14A,Vibrio cholerae O1,Oenococcus oeni,Bos taurus,Sus scrofa,Equus caballus,Gallus gallus,Oncorhynchus mykiss,Homo sapiens,Mus musculus,unidentified)
• Molecular subclassification of triple-negative breast cancer (TNBC) based on gene expression profiling (2016, Homo sapiens,Mus musculus)
• Links between altered glucose and phosphatidylcholine metabolism in breast cancer (2016, Homo sapiens,Mus musculus)
• Cabozantinib provides dual inhibition of MET and VEGFR2 preventing the MET pathway from acting as an alternative pathway in the development of VEGF TKI resistance (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Calloplesiops altivelis,Neotragus moschatus)
• Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Eucalyptus intertexta,Cerobasis alpha)
• Gene expression profiling of normal thyroid tissue from patients with thyroid carcinoma (2016, Homo sapiens,Sequoia sempervirens)
• Following TLR2-ligand interaction a signaling pathway is started using MYD88 as an adaptor molecule (2016, NA)
• BAG2 interacts with the molecular chaperone Hsp70, which plays a prominent role in protein homeostasis (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris)
• CeRNA network modulates the PI3K/Akt signaling pathway (2016, NA)
• PI3K/Akt signaling pathway (2016, NA)
• Transcriptional and posttranscriptional influence of hypoxia on NOS3 mRNA levels (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Notch signaling: its roles and therapeutic potential in hematological malignancies (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Depiction of the organization of the major steroid biosynthetic pathways in the adrenal cortex (2016, NA)
• Toll-like receptors, adapter proteins, and signaling molecules (2016, NA)
• Exogenous avian leukosis virus-induced activation of the ERK/AP1 pathway is required for virus replication and correlates with virus-induced tumorigenesis (2016, NA)
• BDNF-dependent and BDNF-independent mechanisms of pain in uninjured and injured spinal cord (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Diaporthe sclerotioides,Corynebacterium phage gamma)
• Molecular regulation of MSCs during bone formation (2016, NA)
• ECS system-related pathways: The activation of CB1/CB2 receptors has an immense effect on the fate of cells, leading them to apoptosis (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cannabis sativa,Cannabis sativa subsp. indica,Homo sapiens,Canis lupus familiaris)
• Influence of CB1 and CB2 activity on angiogenesis in cancer: After binding to a specific agonist, both CB1 and CB2 receptors are activated (2016, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cannabis sativa,Cannabis sativa subsp. indica,Homo sapiens,Canis lupus familiaris)
• Proposed mechanism for WIN-induced inhibition of prostate LNCaP cells NE differentiation (2016, Homo sapiens,Mus musculus,Bos taurus)
• Bone remodeling: (a) in precursor cell stage, the macrophage-colony stimulating factor (M-CSF) binds to its receptor (c-Fms) (2016, NA)
• Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression (2016, NA)
• Role of Dicer1-Dependent Factors in the Paracrine Regulation of Epididymal Gene Expression (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Armoracia rusticana,Diaporthe sclerotioides,Arachis hypogaea,Mus musculus,Rattus norvegicus,Homo sapiens,Betapolyomavirus macacae)
• Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin (2016, Homo sapiens,Mus musculus,Bos taurus)
• Summary of interactions between diet-induced obesity and tumor growth in Drosophila (2016, NA)
• Mia40 population in the IMS (2016, NA)
• Simplified view of B (2016, NA)
• Microbial Degradation of Cellular Kinases Impairs Innate Immune Signaling and Paracrine TNFA Responses (2016, NA)
• The major proinflammatory glial-mediated alterations to excitatory synapses within the spinal dorsal horn that contribute to central sensitization (2016, NA)
• Schematic depicting the major proinflammatory glial-mediated changes to inhibitory synapses within the spinal dorsal horn that facilitate central sensitization (2016, NA)
• Plant solution to the CDK conundrum in the DNA damage response (2016, NA)
• Metabolic pathway for the production of 1,2-propanediol (1,2-PDO) (2016, Escherichia coli,Corynebacterium glutamicum,Klebsiella pneumoniae,Pseudomonas putida,Enterococcus faecalis,Synechocystis sp. PCC 6803,Synechocystis sp.,Clostridium acetobutylicum,Limosilactobacillus reuteri,Cupriavidus necator,Bacillus amyloliquefaciens,Clostridium butyricum,Levilactobacillus brevis,Pantoea agglomerans,Citrobacter freundii,Klebsiella oxytoca,Streptococcus equinus,Clostridium pasteurianum,Pseudomonas denitrificans nom. rej.,Actinobacillus succinogenes,Lentilactobacillus buchneri,Klebsiella pneumoniae MGH 78578,Citrobacter werkmanii,Saccharomyces cerevisiae,Nitzschia alba,Rhodotorula toruloides,Cinnamomum camphora,Butea monosperma,Umbellularia californica,Fistulifera solaris,Rhodosporidiobolus fluvialis,Homo sapiens)
• Metabolic regulation of the pluripotent epigenetic landscape (2016, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus,Oryctolagus cuniculus,Macaca mulatta)
• Signaling pathways associated with differentially methylated candidate genes were predicted by Ingenuity Pathway Analysis™ (2016, Mus musculus,Rattus norvegicus,Zea mays,Mouse mammary tumor virus,Middle East respiratory syndrome-related coronavirus,Sequoia sempervirens,Homo sapiens,Bos taurus,Escherichia coli,Gallus gallus)
• Succinate causes cardiomyocyte hypertrophy via GPR91 activation (2016, NA)
• Signaling pathways relevant to glial neoplasms in adults and children (2016, NA)
• Integrated grapevine HY5 and HYH community gene co-expression and cis-regulatory subnetwork (2016, NA)
• SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer (2016, NA)
• Schematic model representing MSP as a negative regulator of NASH in hepatocytes and macrophages (2016, NA)
• CTHRC1 function in the tumor microenvironment (2016, NA)
• Interaction between stress, the autonomic nervous system, the immune system and the kynurenine pathway in the etiology of depression (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Multitargeted modulation of estrogen carcinogenesis by botanicals (2016, Glycine max,Medicago sativa,Zingiber officinale,Linum usitatissimum,Silybum marianum,Angelica sinensis,Trifolium pratense,Trigonella foenum-graecum,Rheum rhabarbarum,Humulus lupulus,Valeriana officinalis,Vaccinium macrocarpon,Vitex agnus-castus,Rheum rhaponticum,Viburnum opulus,Homo sapiens)
• Differences in the cell cycle machinery of B cells (a) and undifferentiated embryonic stem (ES) cells (b) (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Repeatability of cortisol stress response in the European sea bass (Dicentrarchus labrax) and transcription differences between individuals with divergent responses (2016, Dicentrarchus labrax,Homo sapiens)
• Transcriptome and Metabolite analysis reveal candidate genes of the cardiac glycoside biosynthetic pathway from Calotropis procera (2016, NA)
• Illustration of proposed mechanism underlying GNMT deficiency induced triglycerides accumulation and insulin resistance in the liver (2016, NA)
• Simplified diagram of the adaptive and apoptotic pathways of ERS (2016, NA)
• ErbB/HER downstream signaling pathways may influence the ability of ErbB/HER and other kinase inhibitors to modulate MHC expression (2016, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus,Mycobacterium tuberculosis,Corynebacterium phage gamma)
• Role of areca nut induced JNK/ATF2/Jun axis in the activation of TGFB pathway in precancerous Oral Submucous Fibrosis (2016, NA)
• Pharmacokinetic and pharmacodynamic evaluation of ibrutinib for the treatment of chronic lymphocytic leukemia: rationale for lower doses (2016, NA)
• Role of miR-9 in zebrafish brain development.Notes: (A) Zebrafish forebrain: In the forebrain, miR-9 inhibits proneural gene her6 and targets Fgf signaling pathway genes (dusp6, pea3) (2016, NA)
• The Pga1-mediated signal transduction pathway, showing the effectors AC and PKA previously reported in different fungi, along with newly identified effectors and proteins and their relation with the cellular processes regulated by Pga1 (2016, NA)
• Identification of novel peptoid agonists of fibroblast growth factor receptor using microarray-based screening (2016, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Canonical Wnt signaling pathway (2016, NA)
• Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation (2016, NA)
• Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation (2016, NA)
• Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier (2016, Escherichia coli,Homo sapiens)
• Life cycle of blebs is governed by 2 small GTPases (2016, NA)
• Complement cascade (2016, NA)
• Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells (2016, NA)
• AMP-activated protein kinase as a target for pathogens: friends or foes? (2016, NA)
• Gene expression changes in neurotransmitter signaling pathways (2016, NA)
• Gene expression changes in the elements of postsynaptic signaling cascades (2016, NA)
• An ID2-dependent mechanism for VHL inactivation in cancer (2016, NA)
• Metabolic pathway of retinoic acid (2016, Homo sapiens,Mus musculus,Armoracia rusticana,Papaya ringspot virus)
• Altered gene expression in the JNK signaling pathway during diapause (2016, NA)
• The signalling pathways mediating PTH and BMP-2 induced regulation of Phospho1, Smpd3 and Alpl in osteoblast cells (2016, NA)
• TLR4, MyD88 and TRAF6 down-regulation following glutamine administration in LPS-stimulated peripheral blood leukocytes of pancreatic cancer patients (2016, Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mus musculus,Rattus norvegicus,Homo sapiens,Agaricus bisporus)
• Possible function network of SolyWRKY Group III TFs in response to TYLCV infection (2016, NA)
• A probable signaling pathway of folic acid mediated modulation of inflammatory response in microglia cells (2016, NA)
• Estrogen Signaling Pathway (2016, NA)
• Mechanisms regulating CD4+ and CD4+CD25+forkhead box protein 3 (FoxP3) balance (2016, Homo sapiens)
• Mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3 kinase (PI3K) pathway with downstream effectors (2016, NA)
• PI3K/AKT/mTOR pathway is a critical pro-survival cell signaling pathway within NETs that mediates cell growth and peptide translation (2016, NA)
• Epidermal growth factor receptor signaling along with co-activated other receptor tyrosine kinases (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• TGFB signaling and regulation (2016, NA)
• Possible resistance pathways to epidermal growth factor receptor blockade; gain of mutations in KRAS, BRAF, and PIK3CA and upregulation of other receptor tyrosine kinases (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Phosphatidylinositol 3 kinase/Akt pathway (2016, Homo sapiens,Mus musculus,Talaromyces funiculosus)
• Signal transduction pathway mediated through CLEC-2 (2016, NA)
• In NSCLC cells harbouring activating mutations in the epidermal growth factor receptor (EGFR) and treated with the tyrosine kinase inhibitor (TKI) Gefitinib, Ras/ERK and PI3-kinase-Akt signalling are inhibited (2016, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Bos taurus)
• Circadian oscillations in intracellular organelle’s structure and function (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney (2016, NA)
• Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway (2016, NA)
• Thiopurine metabolic pathway (2016, NA)
• FAK and paxillin, two potential targets in pancreatic cancer (2016, Human papillomavirus,Deltapapillomavirus 4,Bovine papillomavirus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Nicotiana tabacum)
• EtOH-induced BK channel internalization via Wnt/Beta-catenin signaling (2016, Rattus norvegicus,Homo sapiens)
• Regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways (2016, Homo sapiens,Mus musculus,Bos taurus,Danio rerio,Diaporthe sclerotioides)
• BMP signaling and its paradoxical effects in tumorigenesis and dissemination (2016, NA)
• Integrin A2B1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma (2016, NA)
• Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways (2016, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Possible signaling cascades of NOB in cells (2016, Citrus reticulata,Citrus unshiu,Citrus depressa,Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli SCD1,Homo sapiens,Bos taurus,Danio rerio,Apis mellifera)
• Thapsigargin sensitizes human esophageal cancer to TRAIL-induced apoptosis via AMPK activation (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Undaria pinnatifida,Homo sapiens)
• Carbon Ion-Irradiated Hepatoma Cells Exhibit Coupling Interplay between Apoptotic Signaling and Morphological and Mechanical Remodeling (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Osteosarcoma cell proliferation is regulated by lncRNAs, including H19, MALAT1, ANCR, and PACER (2016, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Role of the Tomato Non-Ripening Mutation in Regulating Fruit Quality Elucidated Using iTRAQ Protein Profile Analysis (2016, Saccharomyces cerevisiae,Arabidopsis thaliana,Glycine max,Solanum lycopersicum,Solanum tuberosum,Fragaria x ananassa,Botrytis cinerea,Escherichia coli,Agrobacterium tumefaciens,Bradyrhizobium japonicum,Clavibacter michiganensis,Clavibacter michiganensis subsp. michiganensis,Cauliflower mosaic virus,Tobacco rattle virus,Pan troglodytes rhadinovirus 1,Homo sapiens)
• EGFR signaling pathway modified from MetaCore® (2016, NA)
• HER2/PI3K/PTEN/Akt/mTORC pathway and potential sites for intervention with small molecule membrane‐permeable inhibitors and monoclonal antibodies (MoAbs) (2016, NA)
• mTOR signalling pathway (2016, NA)
• Cellular signalling upstream and downstream of mammalian target of rapamycin (mTOR) complexes (2016, NA)
• Fast action antidepressants activate mTOR (2016, NA)
• Mechanisms involved in the delay of therapeutic response to classic antidepressants in MDD patients (2016, NA)
• Targeting mTOR for neurodegenerative disorders (2016, Saccharomyces cerevisiae,Homo sapiens)
• Comparative model of transcriptional activation of ERA by cognate ligand versus cAMP signaling in the absence of estrogen (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,vectors)
• Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis (2016, NA)
• GADD45B, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens (2016, NA)
• Somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy (2016, NA)
• Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer (2016, NA)
• Heat Stress and Lipopolysaccharide Stimulation of Chicken Macrophage-Like Cell Line Activates Expression of Distinct Sets of Genes (2016, NA)
• Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency (2016, NA)
• RAPA inhibits LPS-induced neuroinflammation via the mammalian target of rapamycin complex 1 signaling pathway (2016, NA)
• Schematic showing the mechanism of IGFBP-2-mediated regulation of Beta-catenin pathway in glioma cells involving A5B1 integrin, FAK and GSK3B (2016, Homo sapiens,Mus musculus)
• The Kynurenine Pathway Is a Double-Edged Sword in Immune-Privileged Sites and in Cancer: Implications for Immunotherapy (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Macaca mulatta,Human immunodeficiency virus)
• Kynurenine pathway enzyme IDO plays a central role in testicular immune privilege.Notes: IDO expression by Sertoli cells and by macrophages contributes to testicular immune privilege, resulting in tolerance to spermatozoa and to infectious agents (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Macaca mulatta,Human immunodeficiency virus)
• How Thbs4 functions as an intracellular regulator of muscle cellular attachment and membrane stability (2016, NA)
• Hypoxia stimulates TGFB activity and downstream Fbln5 expression in PDA (2016, Mus musculus,Homo sapiens)
• Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals (2016, NA)
• Upstream and downstream mechanisms of the ERK5 signaling cascade in DRG neuronsDashed lines indicate the need for further examination of possible signaling or the mechanism, which is complicated and abbreviated in this text (2016, NA)
• Signaling network connecting RAS and mir-200 regulates apoptosis and EMT in cancer cells (2016, NA)
• Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling (2016, NA)
• Re-purposing of curcumin as an anti-metastatic agent for the treatment of epithelial ovarian cancer: in vitro model using cancer stem cell enriched ovarian cancer spheroids (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Curcuma longa,Dictyostelium discoideum)
• Novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Calloplesiops altivelis)
• Role of the CaSR, GA11 and AP2 complex in the regulation of PTH secretion and renal tubular calcium reabsorption (2016, NA)
• Regulation of Posttranslational Modifications of HMGB1 During Immune Responses (2016, NA)
• Chemerin/GPR1 signaling suppresses progesterone synthesis and secretion during follicle/corpus luteum development and luteolysis in mice (2016, NA)
• KEGG pathway for insulin signaling (2016, Homo sapiens)
• Current hypotheses for IFNGamma-mediated effect on NSPC activity.Notes: IFNG binds to the IFNG receptor (IFNGR1 and 2) and activates Janus-activated kinases 1 and 2 and signal transducers and activators of transcription-1 (JAK-STAT1) pathway (2016, Human alphaherpesvirus 1,Human betaherpesvirus 5,Zika virus,Measles morbillivirus,Japanese encephalitis virus,Murid betaherpesvirus 1,Sindbis virus,Venezuelan equine encephalitis virus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Mechanisms through which rolipram (ROL) attenuates pain behavior in bone cancer pain (2016, NA)
• Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway (2016, NA)
• Oncolytic vaccinia virus combined with radiotherapy induces apoptotic cell death in sarcoma cells by down-regulating the inhibitors of apoptosis (2016, Human alphaherpesvirus 1,Vaccinia virus,Measles morbillivirus,Reovirus sp.,Vaccinia virus GLV-1h68,Mammalian orthoreovirus 3 Dearing,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Armoracia rusticana,Matthiola incana,Homo sapiens,NA)
• Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1A and sphingosine kinase 1 (2016, Homo sapiens,Mus musculus,Bos taurus)
• Components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model (2016, NA)
• miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival (2016, NA)
• Functional long noncoding RNAs (lncRNAs) in inflammatory pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Bisdemethoxycurcumin exerts pro-apoptotic effects in human pancreatic adenocarcinoma cells through mitochondrial dysfunction and a GRP78-dependent pathway (2016, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis BCG str. China,Homo sapiens,Bos taurus,Curcuma longa)
• Autophagy as an emerging therapy target for ovarian carcinoma (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Vaccinia virus)
• Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex (2016, NA)
• Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Fasciola hepatica)
• Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma (2016, NA)
• Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method (2016, Hepatitis B virus,Hepatitis C virus genotype 4,Homo sapiens,Mus musculus)
• Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method (2016, Hepatitis B virus,Hepatitis C virus genotype 4,Homo sapiens,Mus musculus)
• Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method (2016, Hepatitis B virus,Hepatitis C virus genotype 4,Homo sapiens,Mus musculus)
• Differentially expressed miRNAs in triple negative breast cancer between African-American and non-Hispanic white women (2016, Homo sapiens,Diaporthe sclerotioides)
• Interrelationship among signaling pathway, gene regulatory network and metabolic pathway in a cell (2016, NA)
• p53 dependent and independent tumor suppressive functions of ARF (2016, Homo sapiens,Mus musculus,Human papillomavirus type 16,Dipturus trachyderma)
• S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Olea europaea,Homo sapiens,Mycobacterium tuberculosis)
• (Opposite and overleaf) Visualizing drug action (2016, NA)
• Proposed model for the profibrotic regulation of GLUT1 expression by TGFB (2016, NA)
• Metabolic pathways associated with DA (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Bos taurus,Gallus gallus,unidentified,Phytolacca americana)
• Inositol mechanisms of action in cancer cells (2016, Saccharomyces cerevisiae,Oryza sativa,Glycine max,Triticum aestivum,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Cyprinus carpio)
• Reelin signaling pathway in the developing cortex (2016, NA)
• Jak-STAT signaling pathway (2016, NA)
• TGFB signaling pathway (2016, NA)
• P53 signaling pathway (2016, NA)
• Reelin signaling pathway in the adult brain, which regulates synaptic function (2016, NA)
• Sulfatase-1downregulates mesothelin and leads to reduction in lymphatic metastasis (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus)
• G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion (2016, Bos taurus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus)
• Silencing of Profilin-1 suppresses cell adhesion and tumor growth via predicted alterations in integrin and Ca2+ signaling in T24M-based bladder cancer models (2016, NA)
• NTS/NTR1 co-expression enhances epithelial-to-mesenchymal transition and promotes tumor metastasis by activating the Wnt/Beta-catenin signaling pathway in hepatocellular carcinoma (2016, NA)
• Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies (2016, NA)
• Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma (2016, NA)
• FGFR3-TACC3 fusion in solid tumors: mini review (2016, Homo sapiens,Mus musculus,unidentified,Mycobacterium tuberculosis variant bovis BCG)
• Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer (2016, NA)
• Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer (2016, NA)
• PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer (2016, NA)
• Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells (2016, NA)
• MiR-128 reverses the gefitinib resistance of the lung cancer stem cells by inhibiting the c-met/PI3K/AKT pathway (2016, NA)
• Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1/2 pathway (2016, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proteomic analysis uncovers common effects of IFNG and IL-27 on the HLA class I antigen presentation machinery in human cancer cells (2016, NA)
• On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer (2016, NA)
• MicroRNAs and epithelial-mesenchymal transition in prostate cancer (2016, Homo sapiens,Mus musculus)
• TP53 mutation hits energy metabolism and increases glycolysis in breast cancer (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster,clinical samples)
• Hydrogen sulfide in DN (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Pieris brassicae)
• Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner (2016, Armoracia rusticana,Diaporthe sclerotioides,Triticum aestivum,Allium cepa,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Activation of mGlu5 receptors triggers diverse distinct and converging signalling pathways (2016, NA)
• Assays for the identification of G protein signalling pathways using the constitutive activity of an orphan GPCR (2016, NA)
• Diagram showing key components of the IL‐6 signal transduction pathway that could account for lipogenic gene expression in hepatocytes (2016, NA)
• Newly synthesized FGFR1 can enter either the constitutive membrane pathway or regulated nuclear pathway in membrane pathway the receptor is processed and glycosylated in Golgi and accumulates in plasma membrane (2016, NA)
• Cpb1–C3–C3aR pathway amplifying p38 MAPK signaling downstream of TLR4 and Ifnar activation in macrophages (2016, NA)
• Model illustrating the mode of action of RLTPR in T cells (2016, NA)
• Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer (2016, NA)
• Indoleamine 2,3-dioxygenase regulates anti-tumor immunity in lung cancer by metabolic reprogramming of immune cells in the tumor microenvironment (2016, NA)
• Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis (2016, NA)
• Bmi1 Loss in the Organ of Corti Results in p16ink4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro (2016, NA)
• Regulation of TLR folding, trafficking, and cleavage (2016, NA)
• Schematic model of the Wnt/beta-catenin pathway (2016, NA)
• Schematic model of the Wnt/beta-catenin pathway in Alzheimer disease (2016, NA)
• Nutrients-mTOR-miRNA signaling in skeletal myogenesis (2016, Mus musculus,Rattus norvegicus,Sus scrofa,Ovis aries,Homo sapiens,Siniperca chuatsi)
• FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Diaporthe sclerotioides,clinical samples)
• Extracellular vesicles (EVs) originate through different mechanisms (2016, Bos taurus,Canis lupus familiaris,Sus scrofa,Ovis aries,Eutheria,Homo sapiens,Mus musculus)
• Possible route of central mediation of stress induced signals by NUCB2/nesfatin-1 (2016, NA)
• NMI influences cancer initiation (2016, NA)
• NMI inhibits cancer progression (2016, NA)
• Genes upregulated after RSV infection (2016, NA)
• Epigenetic mechanisms mediate DEP effects on asthma pathogenesis (2016, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Molecular signaling events of brain-derived neurotrophic factor-mitogen-activated protein kinase pathway and depression (2016, NA)
• Major pathways affected in cancer- and drug-induced cachexia (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Vasconcellea candicans)
• Signaling pathway involving mTORC1 (2016, NA)
• Relevant aspects of complement activation and inflammasome activation with their possible interconnection (2016, NA)
• GSK3B in TLR4 responses (2016, NA)
• GSK3B in TLR3 signaling (2016, NA)
• Levels of miR-146a and miR-146b are regulated by innate immune signaling (2016, NA)
• Schematic model of metabolic regulation by S6K1 in two ways (2016, Homo sapiens,Mus musculus)
• Fine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway (2016, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human gammaherpesvirus 8,Human betaherpesvirus 6,Simian sarcoma-associated virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,vectors,NA)
• Diagrammatic representation of the integration of leptin and insulin signals in the regulation of energy homeostasis in the central nervous system (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Role of TSN in carcinogenesis (2016, NA)
• Ubc13: the Lys63 ubiquitin chain building machine (2016, NA)
• Activation of glycerophospholipid metabolism-related genes in response to cold storage (2016, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Glycine max,Solanum lycopersicum,Solanum tuberosum,Cucumis sativus,Spinacia oleracea,Gossypium hirsutum,Mangifera indica,Citrus sinensis,Citrus reticulata,Persea americana,Mimosa pudica,Cucurbita ficifolia,Homo sapiens,NA)
• Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis (2016, Saccharomyces cerevisiae,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Homo sapiens,Mus musculus)
• SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Proposed mechanism by which miR-125b regulates ALS microglia phenotype and toxicity (2016, NA)
• Molecular mechanisms and signaling pathways of ferroptosis (2016, NA)
• Hypothetical TRPC4- / TRPC6-mediated signaling pathway downstream of TGFB1 in InMyoFib cells (2016, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• Power-Law Modeling of Cancer Cell Fates Driven by Signaling Data to Reveal Drug Effects (2016, NA)
• Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations (2016, NA)
• Coupling of toxic and pro-inflammatory lipids and innate immune response (2016, NA)
• Uncovering the Complex Transcriptome Response of Mytilus chilensis against Saxitoxin: Implications of Harmful Algal Blooms on Mussel Populations (2016, NA)
• Stimuli for degranulation of mast cells and basophils and interplay/overlap with type II-IV reactions (2016, NA)
• Integrating Candida albicans metabolism with biofilm heterogeneity by transcriptome mapping (2016, Candida albicans,Homo sapiens)
• Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK/ERK signaling pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Triportheus paranensis)
• Diagram of pathways by which AGEs affect genes involved in steroid synthesis and follicular development (2016, NA)
• Signal transduction mediated by the extracellular calcium-sensing receptor (CaR) (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Paracentrotus lividus,Aplysia californica,Homo sapiens)
• Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae (2016, NA)
• Canonical Wnt signalling pathway (2016, NA)
• ERK1/2 MAPK signalling in response to different oncogenic stimuli (2016, NA)
• Loss of negative feedback contributes to resistance to Raf and MEK1/2 inhibitors (2016, NA)
• Complement-dependent cytotoxicity and inflammation (2016, NA)
• Formal modeling and analysis of ERA associated Biological Regulatory Network in breast cancer (2016, NA)
• Toll-like receptor signaling during ischemia–reperfusion injury (2016, NA)
• Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol (2016, NA)
• Genome evolution in the allotetraploid frog Xenopus laevis (2016, Xenopus laevis,Homo sapiens)
• Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data (2016, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae)
• Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response? (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Molva molva,Calotropis gigantea)
• Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway (2016, NA)
• MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway (2016, NA)
• RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy (2016, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Turdus migratorius)
• Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2A kinase in cortical neurons (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Global gene profiling of aging lungs in Atp8b1 mutant mice (2016, NA)
• Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events (2016, NA)
• The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care (2016, NA)
• Oncogenic regulation of tumor metabolic reprogramming (2016, NA)
• De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells (2016, Homo sapiens,Mus musculus,Caenorhabditis elegans,Carnobacterium mobile)
• Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network (2016, NA)
• Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells (2016, Homo sapiens,Mus musculus,Bos taurus)
• Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression (2016, NA)
• Regulation of IRF1 and IRF1-dependent late-phase gene expression by IL1B after DUSP1 silencing and glucocorticoid treatment (2016, Homo sapiens)
• Role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Progress and perspective of TBX6 gene in congenital vertebral malformations (2016, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• LncRNAs in pancreatic cancer (2016, Homo sapiens,Mus musculus,Nicotiana tabacum,clinical samples)
• IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin (2016, NA)
• Seven protective miRNA signatures for prognosis of cervical cancer (2016, Homo sapiens,Nicotiana tabacum,Human papillomavirus)
• Possible model of TIPE2 inhibition of activation of TAK1 signaling (2016, Mus musculus,Homo sapiens)
• microRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA/NFKB (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Switching off malignant mesothelioma: exploiting the hypoxic microenvironment (2016, Homo sapiens,Mus musculus,Equus caballus,Betapolyomavirus macacae)
• Theoretical model of how PRDX floodgate signalling may transduce exercise-induced H2O2 signals in skeletal muscle (2016, NA)
• Subanesthetic isoflurane relieves zymosan-induced neutrophil inflammatory response by targeting NMDA glutamate receptor and Toll-like receptor 2 signaling (2016, NA)
• Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling (2016, NA)
• PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma (2016, NA)
• Mechanosensation of olfactory sensing neurons shares a common signaling pathway with odorant perception (2016, NA)
• Interactions of NIK wild-type and mutants (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Interaction network of the noncanonical NFKB signaling pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Dietary triglycerides as signaling molecules that influence reward and motivation (2016, NA)
• Growth factor progranulin promotes tumorigenesis of cervical cancer via PI3K/Akt/mTOR signaling pathway (2016, Homo sapiens,Mus musculus,Bos taurus,Human papillomavirus type 16,Cerobasis alpha)
• G-protein-coupled receptors mediate omega-3 PUFAs-inhibited colorectal cancer by activating the Hippo pathway (2016, NA)
• Dopaminergic miRNA nodes in a rich network of connections in synaptic plasticity pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Ca2+Signaling Pathway Proteins that Are Regulated by Homeostatic ScalingIntracellular signaling pathways (2016, NA)
• Cancer pathway targets affected by curcumin (2016, NA)
• Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapy (2016, Caenorhabditis elegans,Leishmania major,Pneumocystis carinii,Pneumocystis jirovecii,Homo sapiens,Mus musculus,Listeria monocytogenes)
• Three major pathways governing sugar perception and signaling in S (2016, NA)
• Impact of pridopidine treatment on BDNF signalling, AKT activation, and the glucocorticoid pathway (2016, NA)
• Structure of (—)-epigallocatechin-3-gallate (EGCG) (2016, NA)
• Proposed alchivemycin biosynthetic pathway (2016, Streptomyces sp. TP)
• Serum markers that change in response to treatment (2016, Candida dubliniensis,Eucalyptus intertexta,Homo sapiens,Mus musculus)
• Steroid-specific protein markers (2016, Candida dubliniensis,Eucalyptus intertexta,Homo sapiens,Mus musculus)
• PD-L1 expression by EGFR-mediated signaling (2016, Homo sapiens,Mus musculus,Patella vulgata)
• Prostate cancer and the unfolded protein response (2016, Saccharomyces cerevisiae,Oryza sativa,Curcuma longa,Tripterygium wilfordii,Angelica sinensis,Marchantiophyta,Lithospermum erythrorhizon,Monascus pilosus,Mus musculus,Rattus norvegicus,Homo sapiens,Apis mellifera,uncultured actinomycete)
• Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer (2016, NA)
• Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2 (2016, NA)
• MTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth (2016, NA)
• Molecular mechanisms of OLIG2 transcription factor in brain cancer (2016, NA)
• Proposed model for the targeting of NRAS-mutant melanoma by ERB ligands (2016, NA)
• Testosterone biosynthetic pathway (2016, Mus musculus,Rattus norvegicus,Bos taurus,Paraechinus aethiopicus,Homo sapiens,Dictyoptera aurora)
• Functional implications of Cav2.3 R-type VGCC in cellular epileptiform activity, excitotoxicity and thetagenesis (2016, Homo sapiens)
• Model showing association of PAX5, CD19, CD3, p53, Ras, Raf, MAPK and Zap70 in B-cell and T-cell type non-Hodgkin's lymphoma (2016, NA)
• Targeted transcriptomic analysis (2016, Homo sapiens,Mus musculus)
• Wnt/Beta-catenin signaling pathway (2016, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Wnt/Beta-catenin signaling therapeutic targets (2016, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Beneficial effects of hepatic CAV‐1 on atherosclerosis protection in DKO mice (2016, NA)
• KEGG analysis of STRING network of C (2016, NA)
• Epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinases 1 and 2 (ERK1/2) signaling pathway (2016, Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Pathway depicting Beta-hydroxy-Beta-methylbutyrate (HMB)-modulated genes identified in the present analysis, which could directly or indirectly affect skeletal muscle cell functions (2016, NA)
• Putative therapeutic mechanisms of action of 11-de in 6-OHDA-induced cell death (2016, Armoracia rusticana,Curcuma longa,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Oryctolagus cuniculus,Sinularia flexibilis,Homo sapiens,Danio rerio)
• TAM-dependent immunity (2016, Dengue virus,Zika virus,West Nile virus,Ebola virus,Mus musculus,Rattus norvegicus,Homo sapiens)
• IL-17 F signaling pathway is epigenetically altered in malignant COPD and non-malignant COPD lung airway epithelial cells (2016, NA)
• TGF‐B1‐induced fibrogenesis (2016, NA)
• JNK pathway and cDDP resistance (2016, NA)
• rno-miRNA-mRNA network affecting VEGF signaling pathway based on the first global prediction.VEGF: Vascular endothelial growth factor (2016, Mus musculus,Rattus norvegicus,Scapteromys aquaticus,Homo sapiens,Diaporthe sclerotioides)
• Evasion of innate immunity by HCV viral proteins (2016, NA)
• Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues (2016, NA)
• Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models (2016, NA)
• Atorvastatin inhibits insulin synthesis by inhibiting the Ras complex (Ras/Raf/extracellular signal-regulated kinase/CREB) in INS-1 cells (2016, NA)
• TP53-centered protein–protein interaction network identified based on the Level 2 gene set using Ingenuity Pathway Analysis (2016, NA)
• Systems Biology Comparison of Ovarian Cancers Implicates Putative Somatic Driver Mutations through Protein-Protein Interaction Models (2016, NA)
• Microarray analysis reveals alterations in the expression of major pathways of cellular metabolism in response to changes in collagen extracellular matrix density.A (2016, NA)
• Gene network associated with ‘cell death and survival, DNA replication, recombination, and repair' in sPIF-treated EVT (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens)
• Signaling pathways at the crossroad between autophagy and EMT (2016, Saccharomyces cerevisiae,Aspergillus janus,Homo sapiens,Mus musculus)
• Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer (2016, Saccharomyces cerevisiae,Aspergillus janus,Homo sapiens,Mus musculus)
• Protein interaction map (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Gene Expression Patterns during Light and Dark Infection of Prochlorococcus by Cyanophage (2016, NA)
• Role of RIPK1 in ConA hepatitis model (2016, NA)
• The serglycin–CD44 signaling pathway in NPC (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Proposed Mtdh-modulated apoptosis induction network in MPC5 cells miR-30s target Mtdh in HG-induced MPC5 cells (2016, NA)
• Differential methylation network of schizophrenia (2016, NA)
• Network constructed based on (2016, NA)
• Upstream and downstream signaling in the mTOR pathway (2016, Homo sapiens,Mus musculus)
• Hedgehog signaling cascade (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,clinical samples,Paraechinus aethiopicus)
• Canonical Hedgehog signaling in cancer: (A) Ligand‐dependent paracrine signaling, (B) Ligand‐dependent autocrine signaling, (C) Ligand‐dependent reverse paracrine signaling, (D) Ligand‐independent signaling (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,clinical samples,Paraechinus aethiopicus)
• Hedgehog signaling activation in TNBC: interplay of ligand‐dependent and ligand‐independent mechanisms (2016, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,clinical samples,Paraechinus aethiopicus)
• Schematic illustrating the G protein-independent role of RGS6 in doxorubicin-induced apoptosis and antiproliferative signaling in the breast (2016, NA)
• RGS6 in central nervous system diseases (2016, NA)
• Anticancer and analgesic activities of B‐caryophyllene (BCP) and B‐caryophyllene oxide (BCPO) (2016, NA)
• Ca2+ induces autophagy (2016, Saccharomyces cerevisiae,Cleyera japonica,Homo sapiens,Gallus gallus,Paracentrotus lividus)
• AMP-activated protein kinase (AMPK) signaling pathway (2016, Camellia sinensis,Melia azedarach,Paullinia cupana,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Putative molecular pathway that links GSK3B activity with the resistance of pancreatic cancer cells to DNA damage induced by gemcitabine and ionizing radiation (2016, NA)
• Proposed model for the accumulation of BRCA1 complexes at DSB sites (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis,Ichnoviriform sonorense)
• Immune therapy and targeted therapy of melanoma (2016, Homo sapiens)
• An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model (2016, NA)
• Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease (2016, NA)
• Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia (2016, Diaporthe sclerotioides,Salvia miltiorrhiza,Artemisia annua,Tanacetum parthenium,Bos taurus,Capra hircus,Pekania pennanti,Homo sapiens,Mus musculus)
• Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression (2016, Drosophila melanogaster,Apamea zeta,Homo sapiens,Mus musculus,Equus caballus)
• Model showing how decreased expression of SRSF2 affects apoptotic pathways in renal cancer cells (2016, NA)
• Cell signaling transduction pathways controlled by WISP-1 in different cancer cells (2016, NA)
• Crosstalk between EGFR and nuclear factorKB (NFKB) signaling pathway (2016, Oryza sativa,Olea europaea,Arachis hypogaea,Helianthus annuus,Scutellaria baicalensis,Sesamum indicum,Carthamus tinctorius,Linum usitatissimum,Hevea brasiliensis,Eleutherococcus senticosus,Bixa orellana,Mus musculus,Rattus norvegicus,Homo sapiens,Cyprinus carpio)
• MTOR signaling network in mammalian cells (2016, NA)
• Insulin-like growth factor receptor 1 (IGF-1R)– and mammalian target of rapamycin (mTOR)–induced alterations upon the canonical IGF-1R signaling cascade, mitogen-activated protein kinase (MAPK) and receptor tyrosine kinase RTKs in Ewing sarcoma (ES) (2016, NA)
• Schematic diagrams illustrating the mechanism by which GSPE protects against IR-induced renal insult by inhibiting the HMGB1-TLR4-p65 pathway (2016, NA)
• Molecular mechanisms of osteoporosis in ACTH-secreting pituitary adenomas (2016, NA)
• Stages of cancer cell colonisation of the bone (2016, NA)
• Schematic drawing of the possible mechanism underlying the effects of resveratrol in relieving (a) nociceptive and(b) inflammatory pain (2016, NA)
• Schematic model of drought responsive proteins involved in photosynthesis, carbon metabolism, fatty acid metabolism, and nitrogen and amino acid metabolism (2016, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Malus domestica,Arachis hypogaea,Cucumis sativus,Brassica napus,Sorghum bicolor,Camellia sinensis,Nicotiana benthamiana,Medicago sativa,Phaseolus vulgaris,Saccharum officinarum,Gossypium hirsutum,Ipomoea batatas,Brassica rapa,Mangifera indica,Brassica juncea,Brassica rapa subsp. pekinensis,Lotus japonicus,Capsicum frutescens,Citrullus lanatus subsp. vulgaris,Oryza sativa Indica Group,Triticum turgidum subsp. durum,Vigna unguiculata,Trifolium repens,Camelina sativa,Hippophae rhamnoides,Mimosa pudica,Glycine soja,Cynodon dactylon,Populus tomentosa,Nicotiana plumbaginifolia,Populus euphratica,Cenchrus americanus,Citrullus lanatus,Serendipita indica,Agrostis stolonifera,Hordeum vulgare subsp. spontaneum,Leymus chinensis,Quercus ilex,Betula platyphylla,Poa pratensis,Musa x paradisiaca,Craterostigma plantagineum,Quercus robur,Gossypium herbaceum,Avicennia marina,Populus cathayana,Tamarix hispida,Populus x canadensis,Festuca pratensis,Sporobolus stapfianus,Dorcoceras hygrometricum,Cistus albidus,Betula platyphylla var. japonica,Ramonda serbica,Carissa spinarum,Cynodon x magennisii,Poa pratensis subsp. pratensis,Epimedium elongatum,Solanum palustre,Parkinsonia aculeata,Homo sapiens,Escherichia coli)
• Intracellular signaling pathways in lymphangiogenesis (2016, NA)
• Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS (2016, Homo sapiens)
• EIF2A serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress (2016, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Lareunionomyces loeiensis,Bison bonasus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Autophagy complexes cell death by necroptosis (2016, Homo sapiens,Saccharomyces cerevisiae)
• NADPH: new oxygen for the ROS theory of aging (2016, NA)
• Functions of three members of the UBXD protein family (UBXN1, P47, and FAF1) that are potentially involved in the prevention of cancer (2016, Saccharomyces cerevisiae,Saccharomyces cerevisiae VR1,Homo sapiens,Mus musculus)
• Major protein cascade and miRNAs in insulin signaling pathway (2016, NA)
• Maternal chromium restriction on the insulin signaling pathway and Beta-catenin-dependent Wnt pathway (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Oryctolagus cuniculus)
• Ecdysone receptor B1 (EcR‐B1) signaling to trigger pruning in MB G and da neurons (2016, Saccharomyces cerevisiae,Agaricus bisporus,Prunus domestica,Homo sapiens,Drosophila melanogaster,Manduca sexta,Papio anubis,Mus musculus,NA)
• Glioblastoma radiosensitisation by inhibiting FGFR1 and PLCG signalling () (2016, NA)
• Canonical and non-canonical hippo pathway in ischemic heart disease (2016, NA)
• Models depicting consequences of PNH-related mutations on NEDD4L stability and PI3K/Akt/mTOR and TGFB/Smad pathways (2016, NA)
• TNF signaling pathway anomalies through antiapoptotic signaling by TNFR1 helped by upregulation of TRAF1 and inhibition of proapoptotic TNFR1 signaling by BIRC1/3 caspase inactivation (2016, NA)
• Quercetin induces tyrosinase and stress response proteins in melanocytic cells (2016, NA)
• Immune effector cells induce tumor cell death through apoptosis and necrotic-like cell lysis (2016, Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus)
• Mammalian target of rapamycin complex 1 (mTORC1) pathway and translation initiation (2016, Dengue virus,West Nile virus,Encephalomyocarditis virus,Chikungunya virus,Dengue virus type 2,Mengo virus,Saccharomyces cerevisiae,Armoracia rusticana,Matthiola incana,Mus musculus,Bos taurus,Oryctolagus cuniculus,Mesocricetus auratus,Aedes albopictus,Corvus brachyrhynchos,Homo sapiens)
• Canonical NFKB pathway (2016, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome,Agaricus bisporus,Dipturus trachyderma)
• Reparative inflammation takes charge of tissue regeneration (2016, NA)
• Functional investigation of lncRNAs (2016, NA)
• Roles of TBX2 and TBX3 in tumorigenesis and tumor progression (2016, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Caenorhabditis elegans,clinical samples,NA)
• MicroRNA-gene interaction networks of the MAPK signaling pathway (2016, Homo sapiens)
• Most highly-rated network of microRNA-1297 target genes in Ingenuity Pathway Analysis (2016, NA)
• Cytokine-cytokine receptor interaction of secreted cytokines (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Eucalyptus intertexta,Homo sapiens)
• Scheme showing role of pro and anti-inflammatory bioactive lipids in IBD (2016, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Caenorhabditis elegans)
• Illustration of the Wnt signaling pathways (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Escherichia coli,Lareunionomyces loeiensis)
• Cordycepin function in chondrogenesis and chondrocyte hypertrophy of MSCs (2016, NA)
• Organ of Corti harbors HCs, which are vulnerable to infections and many pharmaceutical drugs such as aminoglycoside antibodies, for example, streptomycin and neomycin, and the chemotherapeutic agent cisplatin (2016, NA)
• m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks (2016, Saccharomyces cerevisiae,Sorghum bicolor,Homo sapiens,Mus musculus)
• mTOR: An attractive therapeutic target for osteosarcoma? (2016, Homo sapiens,Mus musculus)
• Current relevance of hypoxia in head and neck cancer (2016, NA)
• Inflammasome: an emerging therapeutic oncotarget for cancer prevention (2016, Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Vibrio cholerae,Bacillus anthracis,Citrobacter rodentium,Francisella tularensis,Streptomyces hygroscopicus,Neisseria gonorrhoeae,Mesomycoplasma hyorhinis,Homo sapiens,Mus musculus,Nicotiana tabacum,Influenza A virus)
• Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases (2016, NA)
• Signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases (2016, NA)
• ‘melanoma-enriched’ microRNA miR-4731-5p acts as a tumour suppressor (2016, NA)
• Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma (2016, Homo sapiens,Mus musculus,Bos taurus,NA)
• Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease (2016, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Lareunionomyces loeiensis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• CDK4/6 inhibition: the late harvest cycle begins (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Diagram of the anthocyanins biosynthetic pathway (2016, Vitis davidii,Homo sapiens)
• VEGF/VEGFR signalling pathway in normal vs (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Human immunodeficiency virus 1,Hericium erinaceus)
• Childhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Human immunodeficiency virus 1,Hericium erinaceus)
• Cell migration and focal adhesion disassembly (2016, NA)
• Natural killer (NK) cell/tumor cytotoxicity pathway (2016, NA)
• Schematic diagram showing the role of RAP1A in regulation of tumor metastasis capacities (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Armoracia rusticana)
• Activation of autophagy and caspase-independent apoptosis pathway and proposed mechanism of action of magnetic nanoparticles functionalized with LL-37 on colon cancer cells (2016, Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Human papillomavirus,Respiratory syncytial virus,Homo sapiens,Mus musculus,Entamoeba histolytica)
• Mechanisms of regulated neurotrophin secretion (2016, NA)
• Paradigms and mechanisms of inhalational anesthetics mediated neuroprotection against cerebral ischemic stroke (2016, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Regulation of cellular tension and adhesion by autophagy (2016, NA)
• Proteasome has several roles in AML (2016, Homo sapiens,Mus musculus)
• Proposed mechanisms of kefir peptides-mediated modulation of the lipid metabolism pathway in 30% fructose-induced NAFLD mice (2016, Saccharomyces cerevisiae,Zea mays,herbal medicine,Caulerpa lentillifera,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• TLR and the related TNFR and IL-1R signaling pathways (2016, NA)
• CGRPergic neurotransmission at the vascular level (2016, Armoracia rusticana,Capsicum frutescens,Allium tricoccum,Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Metabolic pathways for methane oxidation (A) and FA synthesis (B) in M (2016, Escherichia coli,Escherichia coli DH5alpha,Methylococcus capsulatus,methanotrophic bacterium,Methylotuvimicrobium buryatense,Methylotuvimicrobium alcaliphilum,type I methanotrophic bacterium,Methylophilus sp.,Methylobacterium organophilum,Methylotuvimicrobium buryatense 5G,Microbacterium sp. 11,Diaporthe sclerotioides,Spinacia oleracea,Homo sapiens)
• Cellular pathways currently being targeted in the treatment of endometrial cancer (EC) and the potential actionable genes in EC identified via Next Generation Sequencing (NGS) (2016, Homo sapiens,Bikinia letestui)
• Proteins modified by lysine methylation from the PhosphoSitePlus database were mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) prostate cancer pathway (2016, NA)
• The HH signaling pathway in lung cancer (2016, NA)
• HH signaling pathway during development (2016, NA)
• Interleukin-33 (IL-33)/ST2 signaling pathway (2016, Human gammaherpesvirus 4,Human papillomavirus,Homo sapiens,Mus musculus,Nicotiana tabacum,Helicobacter pylori)
• IPA-mapped CVD pathway for the 1890 compounds distributed in the top 10 herbs (2016, NA)
• Thyroid cancer-related signaling pathway relational graph (2016, Homo sapiens)
• Path2enet: generation of human pathway-derived networks in an expression specific context (2016, Homo sapiens,Mus musculus)
• Pathway-expression-networks produced for B cell CD19+ (top), T cell CD8+ (bottom left) and T cell CD4+ (bottom right) based on the transformation of the NOTCH Signaling Pathway done with Path2enet (2016, Homo sapiens,Mus musculus)
• Biosynthesis pathways of acetyl-CoA and NAD cofactors, and their involvement in chromatin-related processes (2016, NA)
• Signaling cascades implicated in developmental cell death and tissue homeostasis (2016, NA)
• Mechanisms involved in Escherichia coli K1 manipulation of macrophages (2016, NA)
• Immune evasion mechanisms seen in acute leukemia.Multiple immune pathways and functions are targeted by acute leukemia (2016, NA)
• Pathway of microRNA-7 in gastric cancer (2016, NA)
• Pathway of microRNA-7 in pancreatic cancer (2016, NA)
• MAPKs, TGF-beta and TNFA dependent pathways involved in GFNs toxicity (2016, NA)
• Pathway of microRNA-7 in colorectal cancer (2016, NA)
• Pathway of miR-7 in hepatocellular carcinoma (2016, NA)
• Fibroblast growth factor 21 (FGF21) regulates Sirt 1-mediated release of adiponectin from adipose tissue with relevance to NAFLD and the metabolic syndrome (2016, NA)
• miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NFKB and sustains NFKB activation by decreasing Cylindromatosis expression (2016, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling (2016, NA)
• MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activity (2016, NA)
• Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer (2016, NA)
• Mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Human gammaherpesvirus 8)
• Schematic diagram elucidating signalling pathway of TLR4 and TLR9 responsible for GFNs-induced cytotoxicity (2016, NA)
• Relationship between hypoxia and response to antiangiogenic therapy in metastatic colorectal cancer (2016, NA)
• Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with Beta-catenin-dependent and Beta-catenin-independent signaling pathways (2016, NA)
• Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1A and PERK pathways (2016, NA)
• Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis (2016, NA)
• Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1 (2016, Bos taurus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Armoracia rusticana,Helicobacter pylori)
• Regulatory feedback mechanisms govern Etv2 expression (2016, NA)
• Four possible pathways (circles) by which CNP could activate CFTR (2016, NA)
• Potential regulation pathway of the genes associated with OB morphology, oil content and FA compositions (2016, NA)
• Scheme of mitochondrial retrograde signaling pathways as proposed by Karu (2016, NA)
• Mechanism of appetite regulation by the hypothalamus and peripheral tissues (2016, NA)
• Models of Hippo pathway in fly and mammals (2016, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• The p,p′-DDE-induced effects in promyelocytic HL-60 cells (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Epirrhoe alternata)
• JAK/STAT, Raf/MEK/ERK, and PI3K/PTEN/Akt/mTOR pathway cascades.In the JAK/STAT pathway, JAK2, which can be inhibited by AG490 and/or SOCS3, can phosphorylate STAT3 through downstream signalling (2016, Homo sapiens,Mus musculus)
• Proposed signaling mechanism underlying the neuroprotective role of tPA.tPA enters the cell where it indirectly activates cellular signaling mechanisms, including Janus kinase 2 (JAK2) and/or mammalian target of rapamycin (mTOR) (2016, Homo sapiens,Mus musculus)
• The proposed signaling mechanism involved in irisin‐mediated vasorelaxation and lowering blood pressure in the spontaneously hypertensive rat (SHR) (2016, NA)
• Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi (2016, NA)
• Inflammatory players implicated in lipopolysaccharide- (LPS-) induced M1 polarization of N9 microglial cells and of exosome upregulated microRNAs (2016, NA)
• Classic mechanism for E2 action is E2 diffusing into the nucleus, binding to the nucleus estrogen receptor (ER), combining with ERE on DNA, starting transcription translation and inducing the cycle of multiplication in cancer cells (2016, Spatholobus suberectus,Homo sapiens)
• Phosphatidylinositol 3-kinase (PI3K) pathway: Activation of class IA/B PI3Ks occurs through the stimulation of receptor tyrosine kinases, which is induced by insulin and the concomitant assembly of receptor–PI3K complexes (2016, NA)
• Summary of the mechanism of Dicer regulation in osteogenesis (2016, NA)
• Gluconeogenesis is a multistep metabolic process that generates glucose from pyruvate or a related three-carbon compound (lactate) and glutamine (2016, Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli FBP1,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Canis lupus familiaris)
• Fronto-striatal circuits originate in the frontal cortex and pass through the basal ganglia, which project via the thalamus back to frontal brain areas (2016, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Neuromodulation of the parallel fiber-Purkinje cell (PF-PC) synapse (2016, NA)
• PI3K/AKT/mTOR signaling is regulated by intrinsic feedback (2016, NA)
• Genes and interaction relationship in the module 31 (a) and 35 (b) (2016, NA)
• Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin–Beck disease (2016, NA)
• Metabolic pathways that may be affected by lactate flooding of brain after traumatic brain injury (2016, NA)
• Proposed model on the cross-talk between HGF/c-Met and SphK1/S1P/Spns2/S1P1signaling axis in HGF-mediated lamellipodia formation (2016, NA)
• Proposed model of the mechanism by which GPCRs signal via PKA and PP1 to promote PI3K/AKT pathway activation (2016, Rattus norvegicus,Homo sapiens)
• Summary of NAE metabolism via hydrolysis, oxidation, and glucosylation-malonylation (2016, NA)
• Pleiotropic effects of hyperglycaemia‐induced miR‐126 underexpression and insulin resistance (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Theoretical mechanisms involved in the crosstalk between insulin-like growth factor-I receptor (IGF-IR) and thyrotropin receptor (TSHR) pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Domain structure of retinoic acid-inducible gene-I (RIG-I) (2016, Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Zika virus,Ebola virus,Enterovirus C,Measles morbillivirus,Japanese encephalitis virus,Coxsackievirus B3,Enterovirus A71,Encephalomyocarditis virus,Murine hepatitis virus,Lyssavirus rabies,Foot-and-mouth disease virus,Human orthopneumovirus,SARS coronavirus NS-1,Hepatovirus A,Influenza B virus,Molluscum contagiosum virus,Borna disease virus,Severe fever with thrombocytopenia syndrome virus,Tick-borne flavivirus,Langat virus,West Nile virus strain NY-99,Thogotovirus thogotoense,Homo sapiens,Mus musculus,Cerobasis alpha,NA,NA,NA,NA,NA,NA)
• Calcium sensing receptor (CaSR), a novel signaling mechanism in ASM known for its activity in the parathyroid gland (2016, NA)
• The status of Nrf2-based therapeutics: current perspectives and future prospects (2016, NA)
• p53 suppresses the cell proliferation mediated by the Rb-E2F pathway (2016, NA)
• Hypothetic model illustrating the pivotal role of CD37 status for R-CHOP outcome in DLBCL and the important molecular mechanisms for R-CHOP resistance in CD37−DLBCL and CD37+ABC-DLBCL (2016, Homo sapiens)
• Schematic depiction of aspects of adult olfactory GBC regulation (2016, NA)
• Cell cycle controls developmental decisions (2016, NA)
• Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Iris germanica)
• Functional diagram of the calcium-calmodulin kinase/histone deacetylase 4/5 signaling pathway (according to Liu et al (2016, NA)
• Tissue injected with B. asper venom (2016, NA)
• Metabolic stress-mediated induction of an inflammatory response via ER stress signaling pathways (2016, NA)
• Simplified mechanistic schematics of signaling pathways affected by various agents in TAMH: (a) glutathione, (b) Bcl-2 protein family, (c) Nrf2 pathway, and (d) MAPK signaling (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines (2016, Homo sapiens,Bos taurus)
• EZH2-mediated repression of GSK-3B and TP53 promotes Wnt/Beta-catenin signaling-dependent cell expansion in cervical carcinoma (2016, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana,Human papillomavirus)
• Nrf2 affects mitochondrial function at multiple levels (2016, NA)
• SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Citrus macrophylla,Homo sapiens,Mus musculus,Escherichia coli)
• Inhibition of ribonuclease L (RNase L) activation by picornavirus proteins (2016, NA)
• Action of blockade of inhibitory pathways or activation of costimulatory pathways to promote CD8+T cell priming after vaccination (2016, NA)
• MUC induces inflammasome activation (2016, NA)
• Toll-like receptor signaling pathways (2016, NA)
• IL-17 and IL-17 receptor family (2016, NA)
• MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma (2016, Homo sapiens,Mus musculus)
• Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification (2016, NA)
• TNFR1-elicited signaling pathways (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Streptococcus pneumoniae,Allium sativum)
• Schematic diagram illustrating inhibition of HMGB1-TLR4 signaling pathway by dexamethasone in renal ischemia reperfusion injury (2016, NA)
• Potentially novel olfactory signal pathway existing in AWC olfactory neurons (2016, NA)
• Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development (2016, Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Chromobacterium violaceum,Staphylococcus aureus 1-B-1,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Cricetus cricetus,Avian myelocytomatosis virus,AKT8 retrovirus,Homo sapiens,Plasmodium falciparum,Azadirachta indica)
• Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment (2016, NA)
• AKR1B10 promotes breast cancer metastasis through integrin A5/D-catenin mediated FAK/Src/Rac1 signaling pathway (2016, Homo sapiens,Mus musculus,clinical samples)
• Combination of gemcitabine-containing magnetoliposome and oxaliplatin-containing magnetoliposome in breast cancer treatment: A possible mechanism with potential for clinical application (2016, NA)
• Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers (2016, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• p21-activated kinase 4 signaling pathways in gastric cancer (2016, NA)
• Cellular control of hyperglycemia (2016, Homo sapiens)
• Effect of Pb on the signaling pathway TLR4-MyD88-NFKB and the production of pro-inflammatory cytokines in microglial cells (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic diagram representing chromosomal DNA and the major components of the DDR signaling pathway (top) (2016, NA)
• Possible mechanisms of estrogen or EED action (2016, NA)
• Hypothesized mechanism of procyanidin-mediated mitigation of OA pathogenesis (2016, Armoracia rusticana,Malus domestica,Olea europaea,Arachis hypogaea,Theobroma cacao,Cinnamomum verum,Pinus pinaster,Parkia biglobosa,Rhododendron formosanum,Bos taurus,Oryctolagus cuniculus,Capra ibex,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,NA)
• Erdr1 inhibits melanoma progression (2016, NA)
• Acceleration of osteoblast differentiation through the p53–Akt–FoxO pathway (2016, NA)
• Role of integrins in tumor cell proliferation (2016, Mus musculus,Rattus norvegicus,Venustaconcha ellipsiformis,Amastigomonas sp.,Homo sapiens,Tobacco mosaic virus)
• The integrin outside-in signaling (2016, Mus musculus,Rattus norvegicus,Venustaconcha ellipsiformis,Amastigomonas sp.,Homo sapiens,Tobacco mosaic virus)
• p53 pathway (2016, NA)
• Nucleotide salvage pathway (2016, NA)
• TCA pathway (2016, NA)
• Impact of miR-140 overexpression on proteins involved in the NFKB signaling pathway (2016, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio)
• Mechanism of estradiol-dependent repression of GD3S in ER-positive breast cancer cells (2016, NA)
• Extracellular and intracellular triggers of inflammation in CF airways cells (2016, NA)
• Possible modulation of CBF by pharmacologic agents in COPD (2016, NA)
• Context-dependent TGFB signaling pathway (2016, NA)
• TGR5 regulates different cell signaling pathways (2016, Homo sapiens,Mus musculus,Bos taurus,Hepatitis B virus,Olea europaea)
• TLR signalling pathways regulating p38A MAPK activation (2016, NA)
• Specific intracellular signalling pathways are predicted to be abnormally activated in resting HD monocytes (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Functional gene sets associated with innate immunity and inflammation are enriched in resting HD monocytes (2016, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Two sets of peripheral proteins (blue and red) with the same core proteins (green) are shown (2016, Saccharomyces cerevisiae,Malus domestica,Homo sapiens,Mus musculus)
• LUBAC and UBE2L3 regulate NFKB response (2016, NA)
• Redox homeostasis and metabolic changes during the adaptation to proteasome inhibitors (2016, NA)
• Oestrogen receptor negativity in breast cancer: a cause or consequence? (2016, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Class B Beta-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5 (2016, Oryctolagus cuniculus,Capra hircus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus)
• Acetylation of central metabolic enzymes in desiccated embryos (2016, Picea asperata,Homo sapiens)
• Insulin signaling pathway: intracellular insulin signaling is initiated by insulin receptor tyrosine kinase activity leading to the activation of both the PI3K-Akt pathway and the MAPK pathway (2016, Mus musculus,Rattus norvegicus,Castor fiber,Gallus gallus,Clinitrachus argentatus,Homo sapiens,Canis lupus familiaris,Prunus domestica)
• Interferon (IFN)-λ polymorphisms are associated with hepatitis C virus (HCV) spontaneous resolution and response to treatment (2016, Homo sapiens,Pan troglodytes,Mus musculus,NA)
• Model of signaling pathways in RTK-expressing cells (2016, NA)
• cAMP signaling in the mitochondrial matrix (2016, Drosophila melanogaster,Caenorhabditis elegans,Dictyostelium discoideum,Cerobasis alpha,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Saccharomyces cerevisiae)
• Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating (2016, NA)
• Graphical representation of potential metabolic activities of acidophilic Sideroxydans strains (2016, NA)
• Hypothetical model depicting a potential role of SMAD3 activation in GCT development (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways involved in cell-cell adhesion mediated by E-cadherin in physiological and pathological conditions (2016, Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Monosiga brevicollis,Rhinella arenarum,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Listeria monocytogenes)
• Citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway (2016, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Citrus x paradisi,Homo sapiens,Bos taurus,Escherichia coli)
• T3-actions from genomic and non-genomic effects on cell adhesion and differentiation during vertebrate development (2016, Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Monosiga brevicollis,Rhinella arenarum,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Listeria monocytogenes)
• The canonical RB/E2F pathway in cell cycle progression (2016, Drosophila melanogaster,Caenorhabditis elegans,Dryas iulia,Schmidtea mediterranea,Homo sapiens,Mus musculus,Danio rerio)
• Zrf1 controls the temporal expression of the genes related to cardiomyogenesis (2016, Mus musculus,Homo sapiens)
• Regulation of myofibroblast formation by TGFB1 (2016, Homo sapiens)
• Infergen Stimulated Macrophages Restrict Mycobacterium tuberculosis Growth by Autophagy and Release of Nitric Oxide (2016, NA)
• Illustration of the likely apoptosis pathway in action following C1q binding to SKOV3 cells (2016, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Escherichia coli BL21,Homo sapiens,Mus musculus)
• Innate and adaptive immune responses induced by Avian leukosis virus (ALV) (2016, Avian leukosis virus,Homo sapiens)
• Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration (2016, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Vasconcellea candicans,Calloplesiops altivelis,Homo sapiens,Mus musculus)
• Osteoprotegerin rich tumor microenvironment: implications in breast cancer (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Signal transducer and activator of transcription 3 in myeloid-derived suppressor cells: an opportunity for cancer therapy (2016, NA)
• MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia (2016, Gallus gallus,Danio rerio,Takifugu rubripes,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Diaporthe sclerotioides,Homo sapiens,Avian sarcoma virus CT10)
• Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factorB1 (2016, Homo sapiens,Mus musculus,Bos taurus)
• Wnt/Beta-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling (2016, NA)
• Reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux (2016, NA)
• Novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway (2016, Armoracia rusticana,Human papillomavirus,Human papillomavirus type 16,Vasconcellea candicans,Human papillomavirus types,Livistona chinensis,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• mTORC2/Akt pathway (2016, Homo sapiens)
• microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway (2016, Bos taurus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Mus musculus)
• Signaling pathway of high-fat diet induced IR through TRIM72 and PI3-K/AKT in skeletal muscle (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Gynura divaricata,Homo sapiens,Calloplesiops altivelis)
• Metabolic engineering of Corynebacterium crenatium for enhancing production of higher alcohols (2016, Escherichia coli,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Escherichia coli DH5alpha,Corynebacterium glutamicum,Bacillus subtilis At2,Clostridium acetobutylicum,Ruminiclostridium cellulolyticum,Corynebacterium crenatum,Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Cyberlindnera jadinii,Landoltia punctata,vectors,Homo sapiens)
• Canonical phosphatidylinositol-3-kinase (PI3K) signaling (2016, Human gammaherpesvirus 4,Mouse mammary tumor virus,Homo sapiens,Mus musculus,Panthera onca)
• Network structure for PI3K signaling pathway in Lung Adenocarcinoma (LUAD) (2016, NA)
• Network structure for RAS signaling pathway in Head and Neck Squamous Cell Carcinoma (HNSC) (2016, NA)
• Maladaptive corticostriatal synaptic plasticity mechanism in L-DOPA-induced dyskinesia (LID) (2016, NA)
• Manually curated version of RISN (2016, NA)
• Non-Canonical Role of IKKA in the Regulation of STAT1 Phosphorylation in Antiviral Signaling (2016, Bos taurus,Oryctolagus cuniculus,Human alphaherpesvirus 1,Molluscum contagiosum virus,Homo sapiens,Mus musculus,Armoracia rusticana,Listeria monocytogenes,NA)
• Baicalein reduced metastasis of cancer cells by targeting the MAPK pathway, TGFB/ Smad4 pathway, GPR30 pathway, ezrin, Zinc finger protein X-linked (ZFX) or special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) (2016, NA)
• Signal pathway of IGF-1 by exercise (2016, NA)
• CTHRC1 in multi-signaling pathways (2016, NA)
• Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks (2016, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Drosophila melanogaster)
• Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks (2016, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Drosophila melanogaster)
• Multi-label ℓ2-regularized logistic regression for predicting activation/inhibition relationships in human protein-protein interaction networks (2016, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Drosophila melanogaster)
• Major flowering pathway genes of rice (Oryza sativa) (2016, NA)
• Major flowering pathway genes of bread wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.) (2016, NA)
• Major flowering pathway genes of Arabidopsis thaliana (2016, NA)
• Simplified schematic depiction of a hypothetic PrPc-induced signaling cross-talk between PI3K/Akt and Wnt/Beta-catenin pathway under hypoxic conditions (2016, NA)
• CCI-779 treatment induces expression change in mTOR signaling pathway components (2016, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Capra hircus,Eucalyptus intertexta,Homo sapiens)
• Working Hypothesis of mechanotransduction in EC cells (2016, NA)
• Biosynthetic pathway of pharmaceutical terpenoids (2016, NA)
• Multiple signal transduction pathways and transcriptional networks during cold acclimation in D (2016, Dendrobium officinale,Homo sapiens)
• EGFR activation during CRC progression through demethylation and subsequent upregulation of EREG at the adenoma–carcinoma transition (2016, Bos taurus,Equus caballus,Sequoia sempervirens,Raphanus sativus,Homo sapiens,Rattus norvegicus)
• Summary of the mechanisms for LAPTM4B promoting cancer development (2016, NA)
• Canonical and noncanonical Notch signaling pathways (2016, NA)
• Relationship between visceral obesity, sphingolipids, and metabolic abnormalities (2016, NA)
• RA pathway is differentially regulated in stem cells from VS and SC fat depots (2016, NA)
• Proposed models of two separable mTORC1 pathways (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Adenoviridae)
• MetaCore Immune response_IL-17 signaling pathway (2016, NA)
• Isoprenoid biosynthetic pathways and enzymes in Arabidopsis (2016, Arabidopsis thaliana)
• Genes associated with the NRF2-mediated oxidative stress response pathway that were differentially regulated in aldosterone-producing adenoma (APA) vs zona glomerulosa (ZG) and ZG vs zona fasciculata (ZF) (2016, NA)
• Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer (2016, Homo sapiens)
• Schematic of signaling events involved in Tat-induced changes in NMDARs (2016, Homo sapiens,Rattus norvegicus)
• Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice (2016, NA)
• An APP-induced short circuit in FXS (2016, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,prion)
• Deregulation of Hippo pathway in gastric cancer (2016, NA)
• Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer (2016, Homo sapiens)
• Glucagon-like peptide 1 release from enteroendocrine L cell (2016, NA)
• Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma (2016, NA)
• Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells (2016, NA)
• Detailed information on genes involved in the pathway of circadian rhythm (2016, NA)
• Putative pathological production of AB and NFKB signaling in neurons (2016, NA)
• Proposed model of the interaction of leucine, metformin, and sildenafil on the AMPK/Sirt1/eNOS network (2016, NA)
• Schematic signaling pathways elicited by VEGF (2016, NA)
• Signaling pathways of TLRs (2016, NA)
• Pathway analysis using the KEGG Pathway database (2016, NA)
• Pathway analysis using the KEGG Pathway database (2016, NA)
• Apoptosis signaling activated by Cap and DHC in U251 cells (2016, Armoracia rusticana,Diaporthe sclerotioides,Capsicum frutescens,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,NA)
• Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway (2016, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Danio rerio)
• Glycolytic pathways in tumor cells (2016, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Papio hamadryas,Saccharomyces cerevisiae,Canis lupus familiaris)
• Changes in flux through several EcoCyc-19.5-GEM glycolytic, pentose phosphate, and core biosynthetic pathways during a simulated transition from anaerobic to aerobic conditions (2016, NA)
• Pathway map of NOD-like receptor signaling in independent JU-RME (2016, NA)
• Schematic diagram illustrates and the mechanism b) underlying the inhibition of A549 cells by SiO2@LDH‐VP16 (2016, NA)
• KRAS pathway biology (2016, NA)
• Pre‐ and Post‐Natal Stress Programming: Developmental Exposure to Glucocorticoids Causes Long‐Term Brain‐Region Specific Changes to Transcriptome in the Precocial Japanese Quail (2016, Gallus gallus,Meleagris gallopavo,Coturnix coturnix,Coturnix japonica,Taeniopygia guttata,Mus musculus,Rattus norvegicus,Cavia porcellus,Mus saxicola,Homo sapiens,Arachis hypogaea,Tenebrio molitor)
• DGKA and DGKζ in T cell activation and anergy (2016, Caenorhabditis elegans,Catopsilia pomona,Homo sapiens,Mus musculus,Canis lupus familiaris,Listeria monocytogenes,Corynebacterium phage gamma,NA)
• Metabolic pathways expressed in the deep subsurface (2016, NA)
• Molecular events that connect inflammation to insulin resistance in obesity (2016, NA)
• STRING analysis of metabolic and PI3K-Akt signalling pathways (2016, Homo sapiens,clinical samples)
• PD-1/PD-L1 blockade enhances tumor rejection by activating T cells (2016, Homo sapiens,Mus musculus,Listeria monocytogenes,Bikinia letestui,NA)
• Effect of PD-1 on major signaling pathways and subsequent metabolic reprograming in T cells (2016, Homo sapiens,Mus musculus,Listeria monocytogenes,Bikinia letestui,NA)
• PKB associated signal transduction pathways (2016, Homo sapiens)
• MinePath: Mining for Phenotype Differential Sub-paths in Molecular Pathways (2016, NA)
• Reactive Oxygen Species in Modulating the Caenorhabditis elegans Immune Response (2016, NA)
• ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis (2016, Homo sapiens,Mus musculus,Escherichia coli,Oryctolagus cuniculus,Dipturus trachyderma)
• Classical view of progressive linear cascades in the asymmetry-determining pathway (2016, NA)
• Pathways for equol-induced apoptosis in MGC-803 cells (2016, Meleagris gallopavo,Calloplesiops altivelis,Homo sapiens,Oryctolagus cuniculus,Glycine max)
• Canonical Wnt/Beta-catenin signaling pathway (2016, NA)
• Analysis of Zinc-Exporters Expression in Prostate Cancer (2016, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Possible mechanisms for neuroprotective function of exercise and differences between sexes (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Developmental Stage, Muscle and Genetic Type Modify Muscle Transcriptome in Pigs: Effects on Gene Expression and Regulatory Factors Involved in Growth and Metabolism (2016, NA)
• AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells (2016, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Delonix regia Leaf Extract (DRLE): A Potential Therapeutic Agent for Cardioprotection (2016, Delonix regia,herbal medicine,Magnoliopsida,Cinnamomum verum,Aegle marmelos,Fabaceae,Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Sus scrofa,Homo sapiens,NA)
• Modeling the Role of Lanthionine Synthetase C-Like 2 (LANCL2) in the Modulation of Immune Responses to Helicobacter pylori Infection (2016, Helicobacter pylori,Clostridioides difficile,Clostridioides difficile CD3,Helicobacter pylori SS1,Clostridioides difficile CD45,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,gut metagenome,unidentified influenza virus,NA)
• The role of LET-99 signaling in EMS spindle positioning (2016, Caenorhabditis elegans,Homo sapiens)
• PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases (2016, NA)
• PoCos: Population Covering Locus Sets for Risk Assessment in Complex Diseases (2016, NA)
• An Anti-Parkinson’s Disease Drug via Targeting Adenosine A2A Receptor Enhances AmyloidB Generation and Gamma-Secretase Activity (2016, NA)
• Amide-linked local anesthetics induce apoptosis through apoptotic pathways (the extrinsic death receptor pathway and the intrinsic mitochondrial pathway) and MAPK pathways in human non-small-cell lung cancer cells (2016, Homo sapiens)
• Toll-like receptor signalling pathway (2016, NA)
• Role and mechanism of the AMPK pathway in waterborne Zn exposure influencing the hepatic energy metabolism of Synechogobius hasta (2016, NA)
• Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis (2016, NA)
• Redox states of the mitochondrial NAD and NADP pools are determined by a range of interconnected pathways (2016, NA)
• Astrocytes and neuronal activity play distinct, cooperative roles in neuronal redox homeostasis (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proteomic adaptation of small intestinal mucosa in response to dietary protein limitation (2016, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Zea mays,Glycine max,Homo sapiens)
• Toll-like receptor signaling pathway color-tagged by co-morbidity findings (2016, NA)
• Molecular Approaches to Screen Bioactive Compounds from Endophytic Fungi (2016, NA)
• T-cell receptor (TCR) signaling pathway (2016, Escherichia coli,Homo sapiens)
• Signal transduction pathways in cranial development (2016, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Gallus gallus,Paracentrotus lividus,Coturnix coturnix,Homo sapiens,Oryctolagus cuniculus,Lareunionomyces loeiensis)
• PIN1 dysregulation and targets in hepatocellular carcinoma (2016, NA)
• Hypothetical model of TMEM2 exerting its antiviral functions (2016, NA)
• Cellular metabolic pathway involved in redox homeostasis (2016, Homo sapiens,Mus musculus,Bos taurus,Nicotiana tabacum)
• Reactions induced by oxytocin (2016, NA)
• AHR signaling pathway (2016, NA)
• In silico analysis of Noggin interactions with other proteins (2016, NA)
• Diagram of possible GPC3-mediated signaling pathway in HCC progression.Abbreviations: GPC-3, glypican-3; HCC, hepatocellular carcinoma; P, Phosphorylation (2016, Homo sapiens,Mus musculus)
• Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity (2016, NA)
• Inhibition of the complement system by pathogenic fungi (2016, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Aspergillus nidulans,Cryptococcus neoformans,Nakaseomyces glabratus,Aspergillus terreus,Candida tropicalis,Histoplasma capsulatum,Candida parapsilosis,Paracoccidioides brasiliensis,Pichia kudriavzevii,Cryptococcus gattii VGI,Meyerozyma guilliermondii,Clavispora lusitaniae,Blastomyces dermatitidis,Coccidioides posadasii,Coccidioides immitis,Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Streptococcus pneumoniae,Actinocatenispora sera,Equus caballus,Felis catus,Homo sapiens,Mus musculus,Human immunodeficiency virus,Clinitrachus argentatus)
• Cancer derived peptide of vacuolar ATPase ‘a2’ isoform promotes neutrophil migration by autocrine secretion of IL-8 (2016, NA)
• The canonical and noncanonical pathways by which the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is activated and elicits an inflammatory response (2016, NA)
• Inhibition of HCO3− absorption by HMGB1 in the MTAL (2016, NA)
• Summary of extrinsic, intrinsic and membrane stress apoptotic pathways (2016, Dipturus trachyderma,Triportheus paranensis,Homo sapiens,Mus musculus)
• Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy (2016, Homo sapiens,Escherichia coli)
• Schematic diagram of HGF/c-MET signal transduction pathway (2016, Human gammaherpesvirus 4,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,Helicobacter heilmannii)
• Details of the PMF network model showing deregulated miRNAs and genes that participates to specific connected pathways, linked in turn to biological processes and functions germane to the disease (2016, NA)
• Differentially regulated genes discussed in this paper (2016, NA)
• Probing the PI3K/Akt/mTor pathway using 31P-NMR spectroscopy: routes to glycogen synthase kinase 3 (2016, NA)
• Type I interferon signaling and type I interferonopathies as currently assigned (2016, NA)
• Acute Simian Varicella Virus Infection Causes Robust and Sustained Changes in Gene Expression in the Sensory Ganglia (2016, NA)
• Proteins with known or inferred roles in autophagy that underlie muscle pathologies in mice and humans (2016, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gorilla gorilla,Saccharomyces cerevisiae,Danio rerio)
• Linking identical processes found between two metabolic maps (2016, NA)
• CF airway epithelium and pathogen adaptation (2016, NA)
• Identification of critical paralog groups with indispensable roles in the regulation of signaling flow (2016, NA)
• Data summary (2016, NA)
• Mitochondrial reversible reaction between AcCT and CT and between CoA and AcCoA in skeletal muscles (2016, NA)
• Nitrogen-induced metabolic changes and molecular determinants of carbon allocation in Dunaliella tertiolecta (2016, Dunaliella tertiolecta)
• FAT4 participates in tumor transformation through the Hippo–Wnt signaling pathway by inducing YAP–TAZ activation.Notes: Src-mediated tumorigenesis also results from Src activation to repress FAT4 gene expression via MEK/ERK or cofilin1 (2016, NA)
• Extracellular actin-induced JAK/STAT pathway activation (2016, NA)
• Phosphatidylinositol‐3 kinase (PI3K)–AKT PI3K‐AKT pathway is activated upstream by ligand binding to a growth factor receptor, in this case a receptor tyrosine kinase (RTK) (2016, NA)
• Hypothetical pathway regulating the response of skeletal slow twitch muscle to endurance training: myogenesis, fuel usage, and myosin fiber type change (2016, Mus musculus,Homo sapiens)
• TrkB-mediated signaling pathways and possible therapeutic targets in cancer (2016, NA)
• Pictorial representation of altered GABA receptor signaling due to PCP-SI treatment (2016, NA)
• Proposed signaling pathways leading to ET-1-induced sustained vasoconstriction of the renal afferent arteriole (2016, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Rattus norvegicus,Gallus gallus,Antarctothoa delta)
• Summary of genetic and pharmacological evidence implicating Wnt signaling in developmental cognitive disorders (2016, NA)
• The main molecular and genetic alterations present in hepatocellular carcinoms (HCC) (2016, Homo sapiens,Mus musculus,Nicotiana tabacum,Hepatitis B virus,Alburnus alburnus)
• Diagrammatic representation of the extrinsic and intrinsic apoptotic pathways (2016, NA)
• Beneficial effects of immunobiotic bifidobacteria on the innate immune response against rotavirus in intestinal epithelial cells (IECs) (2016, NA)
• Innate immune response against rotavirus in intestinal epithelial cells (IECs) (2016, NA)
• Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis (2016, Homo sapiens,NA)
• Apoptotic pathways (2016, Homo sapiens)
• The main findings of the study (2016, Mus musculus,Rattus norvegicus,Homo sapiens)
• Akt-protein phosphatase signaling pathway involved in regulating GSK3B phosphorylation (2016, NA)
• Reconstruction of purine biosynthetic pathway in C (2016, NA)
• How autism-risk genes regulate neuronal structure and their sites of action (2016, NA)
• Regulation of Sirt1/Nrf2/TNFA signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity (2016, NA)
• Proposed effect sites of kallistatin through integrin signaling pathway (2016, Bos taurus,Oryctolagus cuniculus,Vulpes vulpes,Mus musculus,Rattus norvegicus,Komagataella pastoris,Komagataella phaffii GS115,Homo sapiens,Adeno-associated virus)
• Osteoclasts arise from hematopoietic monocyte/macrophage precursors upon interaction of RANKL with its receptor RANK (2016, Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• Collagen XVII (C XVII) ectodomain (Ecto) shedding modulates A6B4 integrin-driven motility and proliferation of wound keratinocytes (2016, Homo sapiens,Mus musculus,Cerobasis alpha)
• Regulation of inflammation-driven pathological angiogenesis by CC-chemokines (2016, NA)
• Argon’s molecular mechanism (2016, NA)
• 11-epi-SA-induced apoptotic pathway in HA22T cancer cells (2016, NA)
• Differentially expressed proteins involved in HIF-1 signal pathway (2016, NA)
• Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway (2016, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• RBM5 targets in the EGFR Signaling pathway (2016, NA)
• ‘Apoptotic execution phase’ gene enrichment in cisplatin-treated samples (2016, NA)
• Simplified model for how AhR mediates the RANK/c-Fos signaling axis of osteoclast differentiation and bone resorption (2016, NA)
• Thrombomodulin regulates monocye differentiation via PKCD and ERK1/2 pathway in vitro and in atherosclerotic artery (2016, NA)
• Metabolic pathways in hepatocellular carcinoma (2016, NA)
• RAS-MEK-ERK pathway represents a chain of protein signalling pathway that responds to a mitogen binding to a cell surface receptor (2016, NA)
• Immune response_IL-17 signaling pathway (2016, NA)
• Antennal lobe circuitry underlying long-term central adaption (LTCA) presentation (2016, NA)
• Endogenous levels of cytokinins, gibberellins and jasmonates in rice tissues at seedling stage, tillering stage, grain-filling stage and mature grain stage (2016, NA)
• iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration (2016, NA)
• Hypothesized mechanisms of cancer recurrence or death induced by JAG1‐Notch pathway activation following increased JAG1 expression regulated by various factors (2016, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,clinical samples)
• Deep, Staged Transcriptomic Resources for the Novel Coleopteran Models Atrachya menetriesi and Callosobruchus maculatus (2016, NA)
• Phagocytosis of apoptotic corpses (2016, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lens culinaris,Homo sapiens)
• Mitotic spindle orientation (2016, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lens culinaris,Homo sapiens)
• Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy (2016, NA)
• Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy (2016, NA)
• Silver Nanoparticle-Directed Mast Cell Degranulation Is Mediated through Calcium and PI3K Signaling Independent of the High Affinity IgE Receptor (2016, Escherichia coli,Pseudomonas aeruginosa,Shewanella oneidensis,Mus musculus,Rattus norvegicus,Armoracia rusticana,Lolium multiflorum,Homo sapiens,Bos taurus)
• PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress (2016, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Eucalyptus intertexta,Bos taurus,Escherichia coli,Capra hircus,Escherichia coli FBH1,Homo sapiens,Mus musculus,Dipturus trachyderma)
• Wnt-Beta-catenin signaling pathway (2016, NA)
• Early neurogenesis in cnidarians and basal bilaterians (2015, NA)
• Summary schematic of eye morphogenesis pathways (2015, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Botryllus schlosseri,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,Eucalyptus intertexta,Shigella flexneri)
• 雌激素介导的信号通路。注：本图已获得版权所有者John Wiley and Sons使用许可[Chen GG, Zeng Q, Tse GM (2015, Homo sapiens,Mus musculus,Nicotiana tabacum)
• miRNAs in renal fibrosis (2015, NA)
• Signalling pathways initiated by miRNAs and TGFB in diabetic nephropathy (2015, NA)
• Mechanism of action of statins (2015, NA)
• Everolimus and Sirolimus in Transplantation-Related but Different (2015, NA)
• Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma (2015, Homo sapiens)
• Regulation of innate immune cell function by mTOR (2015, NA)
• Diagram of gemcitabine metabolism and proposed mechanisms of gemcitabine resistance (2015, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Paraechinus aethiopicus)
• Diagrams of the Hedgehog, Wnt, Notch pathways and their roles for gemcitabine resistance (2015, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Paraechinus aethiopicus)
• Apoptotic membrane blebbing through DR5/Casp-3/ROCK1 signaling pathway (2015, NA)
• Glycan processing in the secretory pathway (2015, NA)
• Analysis of pathways responsible for the expression of TGFB target genes (2015, Homo sapiens,Mus musculus)
• Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics (2015, Homo sapiens)
• Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission (2015, Human immunodeficiency virus 1,Respiratory syncytial virus,Vesicular stomatitis virus,Measles morbillivirus,Human alphaherpesvirus 3,Spleen focus-forming virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Vasconcellea candicans,NA)
• Activation of the JAK-STAT pathway by viruses and the biogenesis, fission and fusion life cycle of mitochondria (2015, Human immunodeficiency virus 1,Respiratory syncytial virus,Vesicular stomatitis virus,Measles morbillivirus,Human alphaherpesvirus 3,Spleen focus-forming virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Vasconcellea candicans,NA)
• Putative biosynthetic pathways of the major secondary metabolites in FF (2015, Forsythia suspensa)
• Illustration of the working mechanisms for FGF21 prevention of spontaneous and diabetes-induced germ cell apoptosis (2015, NA)
• Ins and outs of MHC class II-mediated antigen processing and presentation (2015, NA)
• Nutrient Competition between Tumor Cells and T Cells Controls Immune Function within Tumors (2015, NA)
• Molecular interactions and outside versus inside cell identity (2015, NA)
• Expanding the Clinical and Molecular Characteristics of PIGT-CDG, a Disorder of Glycosylphosphatidylinositol Anchors (2015, NA)
• Hematopoietic deletion of COX-2 increases adiposity and AT inflammation in obesity (2015, NA)
• Proposed effect of polyP and retinol on the expression of the fatty acid binding protein 4 (FABP4) and leptin/leptin receptor (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Schematic signaling pathway involved in fertilization‐induced autophagy (2015, NA)
• Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells (2015, NA)
• Proposed signaling pathway modulation in lymphomas by HCS (2015, Gallus gallus,Bufo gargarizans,Duttaphrynus melanostictus,Rhinella jimi,Armoracia rusticana,Mucor spinosus,Helleborus torquatus,Ascidiacea,Leiurus quinquestriatus,Homo sapiens)
• Trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase (2015, NA)
• Modes of epigenetic regulation (2015, NA)
• TGFB signaling pathway in prostate cancer cells (2015, NA)
• Signaling model of Nef-mediated (A) apoptosis/anti-apoptosis, (B) down-regulation of expression of MHC class I molecules, and (C) down-regulation of the expression of CD4 molecules (2015, Human immunodeficiency virus 1,Human immunodeficiency virus,Human immunodeficiency virus 2,Caprine arthritis encephalitis virus,Homo sapiens,Ovis aries,NA)
• Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway (2015, Homo sapiens,Canis lupus familiaris,Chlamydia trachomatis)
• Summary of potential beta adrenergic signaling pathways in canine hemangiosarcoma and human angiosarcoma (2015, NA)
• Hinge-latch model of Nrf2 (2015, NA)
• Cdc37 controls a network of intracellular protein kinases (2015, NA)
• Sketch map of the Wnt5a/Ror2 signaling pathway in bone marrow stromal cells (BMSCs) that derives osteoclast precursor migration and differentiation (2015, NA)
• Extrinsic and intrinsic cues regulate the oligodendrocyte program (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Possible Nucleic acid sensors participation in HBV pattern sensing in the life cycle of HBV (2015, NA)
• Modulation of IGF-1R expression levels is sufficient to restore the AKT/CREB and ERK/Elk-1 intracellular signaling pathway activation profile, resulting in SMN expression increase in SMA mice (2015, Mus musculus,Homo sapiens)
• Experimental methods and design (2015, Rattus norvegicus,Homo sapiens)
• Interaction between ER and NFKB in breast cancer (2015, Homo sapiens)
• Main pathways of NFKB activation (2015, Homo sapiens)
• Schematic depicting mTOR pathway components (2015, Mus musculus,Rattus norvegicus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens)
• In darkness, photoreceptor metabolism is similar to adult neurons (2015, Bos taurus,Sus scrofa,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed role of NEDD4 in IGF-1R signaling (2015, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,Human papillomavirus type 16,Ebola virus sp.,Murine leukemia virus,Mason-Pfizer monkey virus,Homo sapiens,Gallus gallus,Danio rerio,Xenopus laevis,Pan troglodytes,Macaca fascicularis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Schizosaccharomyces pombe,Anopheles gambiae)
• Schematic outline of the experimental approach used in this study (A) (2015, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Armoracia rusticana,Ovis aries,Aleuria aurantia,Homo sapiens,Pseudomonas aeruginosa,Triportheus paranensis,Dryas iulia)
• Impact of Base Excision DNA Repair in Age-Related Neurodegenerative Diseases (2015, NA)
• EtOH metabolism pathway regulates KLF4 expression and function (2015, NA)
• Schematic model of morphogenic gradients controlling striatal development and involved in abnormal neurogenesis in Rarb−/− mice (2015, Homo sapiens,Mus musculus)
• Schematic model of GPCR-mediated gene expression in neurons (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Endocrine therapy resistance in breast cancer: current status, possible mechanisms and overcoming strategies (2015, NA)
• Interaction of the EG F and TGFB pathways in the control of proliferation in breast cancer (2015, Venustaconcha ellipsiformis,Dictyostelium discoideum,Homo sapiens)
• Phosphosites identified in proteins of the RAS-RAF-MAPK and PI3K-AKT-mTOR signaling pathway in H3255 (left panel) and H1975 (right panel) (2015, Armoracia rusticana,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,NA)
• Working model of pyrithione zinc in oral cancer (2015, Homo sapiens,Mus musculus)
• Regulatory structure of the Snf1 pathway (2015, NA)
• Snf1 pathway and its components (2015, NA)
• Caloric restriction, exercise and AdipoR pathway activate AMPK–SIRT1 and PPAR pathways, which may increase longevity in humans (2015, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Illustration of the multiple signalling pathways for TGFB in the VSMC In the normal state, TGFB is sequestered by microfibrils, bound to fibrillin-1 through LTBP-1 and fibulin-4 interactions, until its required release (2015, NA)
• Potential role of CBX2 in the regulation of sex development (2015, NA)
• Signaling pathway regulating the initiation of autophagy and the formation of autophagosomes (2015, NA)
• GPCR/scaffolding protein interactions involved in GPCR signaling pathways (individual examples are discussed in the text) (2015, NA)
• Cellular model for spatial control of GPCR signaling across the plasma membrane and endomembrane system (2015, NA)
• Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy (2015, Homo sapiens)
• Mesenchymal-­epithelial interactions during digestive tract development and epithelial stem cell regeneration (2015, NA)
• Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging (2015, NA)
• Proliferation by crosstalk of miR-204 and miR-17/92 in smooth muscle cells (2015, NA)
• Proliferation and apoptosis by miR-378 in cardiomyocytes (2015, NA)
• Target genes of Tongcheng/Landrace specific DEmiRNAs' KEGG pathways enrichment analysis (a) Landrace specific DEmiRNAs target genes enriched in cell cycle pathway (2015, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Porcine reproductive and respiratory syndrome virus,Homo sapiens,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae,Sus scrofa,NA,NA,NA)
• MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells (2015, NA)
• Novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks (2015, Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Human T-lymphotropic virus 2,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus,Plasmodium falciparum)
• Canonical signalling pathways activated by the EP receptors (2015, NA)
• MAP kinase cascade promotes proliferation within melanoma cells (2015, Homo sapiens,Mus musculus)
• Protein interactome involved in neuroendocrine neoplasm proliferation.Proliferative signaling includes a tightly regulated signaling interactome (including RAS/RAF, MAPK, and PI3K/Akt) (2015, NA)
• Canonical CDK/RB/E2F pathway (2015, NA)
• Bridging topological and functional information in protein interaction networks by short loops profiling (2015, NA)
• Simplified schematic of Notch signaling.Notes: In mammalian cells, Notch receptors are synthesized in the endoplasmic reticulum (ER) (2015, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Oncogenic mutations for the upregulation of EREG expression.Notes: Oncogenic mutations in the EGFR, KRAS, or BRAF genes result in activation of the MEK/ERK signaling pathway, which in turn upregulates EREG expression (2015, NA)
• Profile of ceritinib in the treatment of ALK+ metastatic non-small-cell lung cancer (2015, NA)
• Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.5 Gy of 48Ti ions (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma)
• Ingenuity Pathway Analysis showing the top molecular network in HSPC-derived myeloid cells collected at 6 months after exposure of mice to 0.25 Gy of 48Ti ions (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma)
• Ingenuity Pathway Analysis showing the top molecular Network in HSPC-derived myeloid cells collected at 1 week after exposure of mice to 0.1 Gy of 48Ti ions (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma)
• Vasopressin receptors (2015, NA)
• Molecular mechanism for neurogenesis activated by 5-HT4 receptors by MOS (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Pathways involved in the rapid antidepressant effects of nitrous oxide (2015, NA)
• The degranulatory signaling cascade of RBL‐2H3 (adapted from refs (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Diaporthe sclerotioides,Matthiola incana,Homo sapiens,Carassius auratus)
• Cell signalling during Dictyostelium development.(a) The asexual life cycle of D (2015, NA)
• MiRNA function in the immune system (2015, NA)
• UPRmt signal transduction pathway in mammals and worms (2015, NA)
• Modification of the HIF-mediated switch to anaerobic respiration in osteoclasts.Notes: Osteoclasts specifically increase flux through both the glycolytic pathway and mitochondrial ETC to provide ATP and ROS necessary for bone resorption (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Elephas maximus)
• Putative effects of prolyl hydroxylase domain-containing enzyme inhibitors (PHI) in innate immune response.Notes: Hypoxia, inflammation, and innate immunity have intertwined relationships (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity (2015, Saccharomyces cerevisiae,Homo sapiens)
• Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD+ homeostasis and contributes to longevity (2015, Saccharomyces cerevisiae,Homo sapiens)
• High‐risk human papillomaviruses (HPV) infection disrupts the molecular pathways that regulate epithelial differentiation and cell proliferation (2015, Human papillomavirus,Homo sapiens)
• CD4+ T cell activation by antigen presenting cells and the IL-12/STAT4 pathway (2015, NA)
• CEACAM6 Signaling Pathway (2015, NA)
• Simvastatin and dLGG mediate formation of oxylipin mediators by regulation of MAPK-induced cPLA2 activation and downstream signaling cascades (2015, NA)
• Proposed model for the synergistic effect of docetaxel and resveratrol (2015, Homo sapiens,Mus musculus)
• mTORC2 controls cancer cell survival by modulating gluconeogenesis (2015, NA)
• Role of EtOH-mediated cytotoxicity and neuroinflammation in context to HAND via cPLA2signaling in human astrocytes (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Human immunodeficiency virus 1,Simian immunodeficiency virus,Homo sapiens,Gallus gallus,Armoracia rusticana)
• Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3 (2015, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Cricetulus griseus,Homo sapiens,Mouse mammary tumor virus)
• Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis (2015, Homo sapiens)
• Cell density regulates cancer metastasis via the Hippo pathway (2015, Homo sapiens)
• Main lipid classes and biochemical pathways involved in the production of TAG in developing seeds (2015, Camelina sativa,Homo sapiens)
• Lmx1b and miR135a2 in modulating the Wnt pathway and influencing midbrain size, mDA progenitor specification and neurogenesis (2015, NA)
• WNT/B‐catenin signalling pathway (2015, NA)
• Pathophysiological mechanisms involved in bicuspid aortic valve (BAV) (2015, Mus musculus,Mesocricetus auratus,Homo sapiens,Bos taurus)
• Proposed model of TNFA induced apoptosis signaling cascades and mitochondrial pathway in hippocampal neurons (2015, NA)
• Complex, compartmentalized pathways of NADPH production (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Dipturus trachyderma)
• Oncogenic signalling and nutrient availability influence cell metabolism (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Dipturus trachyderma)
• Proposed model for the action of KP-A021 on the RANK signaling pathways in osteoclast differentiation, bone resorption, and cytoskeletal rearrangement (2015, Mus musculus,Homo sapiens)
• WWOX regulates multiple signaling pathways (2015, Homo sapiens)
• Cellular and molecular targets of MTX, 5FU and irinotecan in the small intestine of the AT (2015, NA)
• Schematic diagram of TRAIL-induced apoptotic signaling cascades (2015, NA)
• Integration of RDGN with TGFB to regulate EMT (2015, NA)
• Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy (2015, Vesicular stomatitis virus,Vaccinia virus,Homo sapiens,Mus musculus)
• HVJ-E-mediated cancer cell death.Notes: (A) HVJ-E-mediated apoptosis signaling in cancer cells with CASP8 (2015, Human alphaherpesvirus 1,Measles morbillivirus,Reovirus sp.,Myxoma virus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,synthetic RNA,NA,NA)
• Hippo pathway signaling in Drosophila and mammals.Note: (A) Signaling diagram (2015, NA)
• Schematic view of the TLR4 signaling pathway.Notes: Upon binding of lipopolysaccharide (LPS) to the TLR4 complex (TLR4–LBP–CD14–MD2), TLR4 signals through MyD88-dependent and/or MyD88-independent pathways (2015, Escherichia coli,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Legionella pneumophila,Yersinia pestis,Francisella tularensis subsp. novicida,Escherichia coli O111B4,Homo sapiens,Mus musculus,Drosophila melanogaster,Respiratory syncytial virus)
• HGF/c-Met signaling cascades.Notes: Upon binding of HGF to its receptor c-Met, c-Met is dimerized and activated by phosphorylation of Tyr 1234 and Tyr 1235 residues (2015, Homo sapiens,Mus musculus)
• Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate (2015, NA)
• Simplified model for phosphatidylserine receptor-mediated efferocytosis (2015, Homo sapiens,Mus musculus)
• Targeting the lncRNA-dependent noncanonical Hedgehog pathway by LNA in combination with classical Hedgehog pathway inhibitors (2015, NA)
• TNFR1 signaling (2015, NA)
• ER stress induced by oncogenic BRAF and modulation of basal autophagy in melanoma (2015, NA)
• Mechanism of MAPK inhibitor-induced resistance in melanoma and its reversal with inhibition of mTOR catalytic activity (2015, NA)
• Autophagy regulatory pathway (2015, Saccharomyces cerevisiae,Nicotiana tabacum,Komagataella pastoris,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• TGFB signaling (2015, Homo sapiens,Mus musculus,Mycobacterium avium)
• DNA damage-dependent regulation of E2F1 (2015, NA)
• Cell cycle-dependent regulation of E2F1 (2015, NA)
• (See previous page) (2015, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Eucalyptus intertexta,Homo sapiens,Escherichia coli,Gallus gallus)
• OGT links cancer cell metabolism and cell survival via regulation of HIF-1A (2015, NA)
• Molecular mechanisms of oncogenic RAS-induced senescence (2015, Homo sapiens)
• General overview of the class I PI3K signaling pathway (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Danio rerio)
• Proposed model depicts that canonical Notch signaling augments the expression of Klf4/5, resulting in conjunctival goblet cell differentiation by down-regulating proliferation and up-regulating transcription of Muc 5/ac in conjunctival epithelium (2015, NA)
• Flatworms have lost the right open reading frame kinase 3 gene during evolution (2015, NA)
• Role of AgNO3 in primary, linear and suggested secondary, lateral ethylene signaling pathway (2015, Arabidopsis thaliana,Eruca vesicaria subsp. sativa)
• Canonical Wnt signaling pathway (2015, NA)
• Genomic Landscape of Response to EGFR Blockade in Colorectal Cancer (2015, Oryctolagus cuniculus,Tragelaphus oryx,Homo sapiens,Mus musculus,clinical samples)
• Disruption of TGF-Beta-mediated tumor suppression in SCLC cells (2015, NA)
• EGFR, HER‐2 and ER with downstream the RAS/RAF/MAPK and PI3K/AKT pathway (2015, NA)
• CAMs can activate neurite outgrowth through different mechanisms (2015, NA)
• Negative regulators of necroptosis (2015, NA)
• Linking Nutrients to Growth through a Positive Feedback Loop (2015, NA)
• ARF1 in mediating gefitinib sensitivity in breast cancer cells (2015, NA)
• Phytic acid biosynthetic pathway (black) and myo-inositol derived pathways for ascorbic acid and raffinose-type oligosaccharides (grey) (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Brassica napus,eudicotyledons,Phaseolus vulgaris,Ipomoea batatas,Ricinus communis,Homo sapiens,Triportheus paranensis)
• Adenosine receptor-mediated signaling pathways (2015, NA)
• Sex-determining Region of Y Chromosome-related High-mobility-group Box 2 in Malignant Tumors: Current Opinions and Anticancer Therapy (2015, Homo sapiens,Mus musculus,Danio rerio)
• Targeting aberrant HH-GLI pathway (2015, NA)
• Key components of the mammalian HH signalling pathway (2015, NA)
• Key components of the Rho/ Rho-associated coiled-coil containing protein kinase (ROCK) signalling pathway (2015, NA)
• Conceptual schematic of the miRNA signal pathway regulated by TGFB2-OT1 in autophagy and inflammation (2015, NA)
• Complementary renoprotective actions of ACEi/ARB and vitamin D in chronic kidney disease (2015, NA)
• GPI-APs in integrin activation and signaling at the uropod (2015, prion,Homo sapiens)
• How the source and context of activated GAs and cAMP may determine whether they enhance or inhibit TCR-stimulated IL-2 transcription (2015, Mus musculus,Cavia porcellus,Homo sapiens,Bos taurus,Bacillus anthracis,NA)
• Genomic profiling of Sézary Syndrome identifies alterations of key T-cell signaling and differentiation genes (2015, NA)
• Regulation of target genes by the Wnt/Beta-catenin asymmetry pathway (2015, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Crosstalk between cell cycle regulators and cellular metabolism (2015, NA)
• Various possible mechanisms of Ca2+-ITPR-mediated control of autophagy (2015, NA)
• Pathways involved in the metabolism of DAG and PA described in this review (2015, Homo sapiens)
• Raf activation by Ras (2015, NA)
• Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways (2015, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Arenicola marina,Phacoides pectinatus,Homo sapiens,Saccharomyces cerevisiae,Aquifex aeolicus)
• The proposed mechanisms of carvacrol cytoprotection against Fe2+-induced apoptosis (2015, NA)
• Mechanistic scheme outlining how ACBPs induce apoptosis (2015, Homo sapiens,Mus musculus)
• Signaling schematic depicting our hypothesis of how 2-methoxyestradiol (2-ME) regulates human aortic smooth muscle cells (HASMC) cell-cycle proliferation (2015, NA)
• Controlling a variety of extracellular and intracellular processes via the phospholipid code (2015, NA)
• Glutamate-mediated effects on the cGMP-NO system leading to monoamine release that in turn can be targeted by pharmacological means, eg (2015, Homo sapiens)
• Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches (2015, NA)
• mTOR in sensing autophagy signals : mTOR inhibition integrates amino acid starvation, growth factor deprivation, decreased ATP or oxygen levels, enhanced reactive oxygen species (ROS) to activate autophagy (2015, NA)
• Molecular regulation of autophagy (2015, Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Klebsiella pneumoniae,Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Ovis aries)
• The biologically relevant candidate genes selected in this pharmacogenomic study (2015, NA)
• Schematic depiction on exogenous LIF mediated intra-cellular signaling pathways for robust self-renewal in mESCs (2015, NA)
• Dysregulation of mTOR signaling pathway and mTOR in sleep phenotype of del 2q23.1 and SMS (2015, NA)
• Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner (2015, NA)
• Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models (2015, NA)
• Energy balance signaling, leptin and insulin interaction with possible ciliary genes (2015, NA)
• Ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells (2015, NA)
• Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network (2015, NA)
• Major AGTR1 signalling pathways linked to cancer cell proliferation, angiogenesis and EMT (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Reduced PARP1 as a Serum Biomarker for Graft Rejection in Kidney Transplantation (2015, NA)
• Comprehensive picture showing gene expression changes and crosstalk of pathways associated with Igf1 and Pacap rescue of apoptotic CGNs (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis (2015, Bos taurus,Oryctolagus cuniculus,Equus caballus,Diaporthe sclerotioides,Raphanus sativus,Homo sapiens,Mus musculus)
• Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies (2015, NA)
• BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling (2015, NA)
• PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response (2015, NA)
• Proposed mechanisms by which loss of TRAF2 in keratinocytes causes a psoriasis-like skin inflammation (2015, Mus musculus,Homo sapiens)
• Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis (2015, Bos taurus,Oryctolagus cuniculus,Equus caballus,Equus asinus,Homo sapiens,Mus musculus,Danio rerio)
• Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Drosophila melanogaster,Danio rerio,Mouse mammary tumor virus)
• Role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications (2015, Mus musculus,Cricetulus griseus,Homo sapiens,Caenorhabditis elegans,Canis lupus familiaris)
• Saikosaponin A inhibits influenza A virus replication and lung immunopathology (2015, NA)
• Plasticity of gene‐regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators (2015, Mus musculus,Homo sapiens)
• Oncogenic function of Orai1 and STIM1 (2015, NA)
• Wnt signaling pathway including microRNA regulation (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,NA)
• Cartilage matrix homeostasis is regulated dynamically by the TGFB signaling pathway (2015, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans)
• Wnt signaling pathway from KEGG (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Fas:FasL interactions (2015, Homo sapiens,Mus musculus,Borreliella burgdorferi)
• Schematic pathway of SOCE in neutrophils, leading to activation of the NAPDH oxidase (2015, NA)
• NFE2L2-Regulated Antioxidant Response in Activated Microglia (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• PI3K/AKT/mTOR signaling pathway and examples of drugs targeting each of its components.Note: RSK, 90 kDa ribosomal protein S6 kinase (2015, NA)
• Man-P-Dol acts as mannosyl donor for the synthesis of M9-DLO, GPI anchors, and C- and O-mannosylated proteins (2015, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Sus scrofa,Escherichia coli K-12,Trypanosoma brucei)
• Different gene expressions in regulation of actin cytoskeleton pathway in AuNR-treated MDA-MB-231 cells (2015, Homo sapiens,Bos taurus)
• Differential gene expression in glycolysis/gluconeogenesis pathway in AuNR-treated MDA-MB-231 cells (2015, Homo sapiens,Bos taurus)
• Omega-3 fatty acids enhance BDNF synthesis and signalling in neurons and also influence cannabinoid-mediated synaptic plasticity (2015, Glycine max,Diaporthe sclerotioides,PX clade,Helianthus annuus,Sesamum indicum,Carthamus tinctorius,Juglans regia,Salmo trutta,Scombridae gen. sp.,Sardina pilchardus,Anchoa mitchilli,Tetraodon lineatus,Homo sapiens,Mus musculus,Rattus norvegicus,Microcebus murinus)
• Pathways and novel targets of TRD (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Epoxyeicosatrienoic Acids Enhance Embryonic Haematopoiesis and Adult Marrow Engraftment (2015, Homo sapiens,Mus musculus,Danio rerio)
• Transcriptional regulation of IL-12p40 (IL12b) in antigen-presenting cells (2015, NA)
• Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress (2015, Homo sapiens)
• Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism (2015, NA)
• The effects of extracellular CypA and MM284 in experimental BA (2015, Homo sapiens,Mus musculus,Simian rotavirus A strain RRV)
• Hypothesis: central neuroendocrine and peripheral mechanisms in generation of sex bias in PH (2015, NA)
• Epidermal growth factor receptor (EGFR) is restricted to the basal surface of the airway epithelial cells (2015, NA)
• Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans,Armoracia rusticana)
• Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells (2015, NA)
• Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine (2015, NA)
• Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purpose (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells (2015, NA)
• Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activation (2015, Armoracia rusticana,Anthriscus sylvestris,Homo sapiens,Mus musculus,Bos taurus,Danio rerio)
• TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition (2015, NA)
• Stromal signalling pathways affecting epithelial cell stem cell function in the cancer microenvironment (2015, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Key players of the mTOR complex1 cascade in LR asymmetry Cartoon depicting a simplified model of the TORC1‐dependent signalling pathway and its physiological outcome (2015, Gallus gallus,Danio rerio,Xenopus laevis,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Chlamydomonas reinhardtii,Homo sapiens,Mus musculus,unidentified)
• Calcium signals tune the fidelity of transcriptional responses (2015, NA)
• Regulatory RNAs controlling vascular (dys)function by affecting TGF-ß family signalling (2015, NA)
• INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• SP600125 has a remarkable anticancer potential against undifferentiated thyroid cancer through selective action on ROCK and p53 pathways (2015, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Triticum aestivum,Bocageia sp.)
• Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer (2015, Homo sapiens,Mus musculus)
• Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryza sativa)
• Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer (2015, Homo sapiens,Mus musculus)
• Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development (2015, Homo sapiens,Mus musculus,Sequoia sempervirens)
• ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription (2015, NA)
• SNP-SNP interaction analysis of NFKB signaling pathway on breast cancer survival (2015, Homo sapiens,Bikinia letestui)
• Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma (2015, NA)
• Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation (2015, NA)
• GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells (2015, NA)
• Down-regulation of IKKB expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma (2015, NA)
• An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer (2015, Homo sapiens,Mus musculus)
• An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer (2015, Homo sapiens,Mus musculus)
• Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors (2015, NA)
• CD147 reinforces [Ca2+]i oscillations and promotes oncogenic progression in hepatocellular carcinoma (2015, Homo sapiens,Mus musculus)
• Radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas (2015, NA)
• Structural basis for the indispensable role of a unique zinc finger motif in LNX2 ubiquitination (2015, Armoracia rusticana,Oryza sativa,Diaporthe sclerotioides,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Mus musculus,Dipturus trachyderma)
• Simplified conceptual model for the central metabolism of oilseed rape and the regulation of carbon partitioning (2015, Brassica napus)
• Monocyte genes associated with the ML ratio are enriched for genes in the interferon signalling pathway (2015, NA)
• Repression of DNA-damage signaling pathways at telomeres (2015, Homo sapiens,Mus musculus)
• Molecular mechanisms behind HIF regulation and responses in cells (2015, Homo sapiens)
• Possible interaction between inflammatory IDO activation and AhR-mediated effects (2015, NA)
• Main pathways of TRP degradation including enzymes and their potential stimuli (modified after [, , , ]) (2015, NA)
• The molecular mechanism proposed for the induction of apoptosis by chrysotile asbestos in A549 human bronchoalveolar carcinoma cells (2015, NA)
• Activation of the methylation cycle in cells reprogrammed into a stem cell-like state (2015, NA)
• Assay for defining the immunostimulatory potential of different RNAs (2015, NA)
• Scheme of a proposed model of fluconazole resistance by the activation of diverse signaling pathways (2015, Homo sapiens,Mus musculus,Candida albicans)
• Wnt signaling pathway (2015, NA)
• Signaling pathways involved in the BMP induced osteogenesis, BMPs bind to receptors on cells to activate downstream signal molecules such as Smads, MAPK and JNK (2015, NA)
• MuSC function are altered in aging (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Diagram illustrating the hypothetical signaling pathway and feed-forward loop in inflammation- and oxidative stress–regulated choroidal endothelial cell (CEC) migration and choroidal neovascularization (CNV) formation (2015, Homo sapiens,Mus musculus)
• PI3K pathway with respective PI3K inhibitors (2015, NA)
• Nrf2 in the metabolism of rapidly proliferating cells (2015, NA)
• Ingenuity pathway analysis showing up (green) and down-regulation (red) of miRNAs involved in ovarian cancer tumor samples when compared to endometriosis samples (2015, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio,Sequoia sempervirens)
• The multiple pathways by which proNGF/NGF can contribute to diabetic retinopathy (2015, NA)
• Dissecting Germ Cell Metabolism through Network Modeling (2015, Homo sapiens,Mus musculus)
• Insulin signaling pathway (2015, NA)
• The pathway involving NPR-C, Egr-1, miR199a-3p and miR199a-5p on ApoE modulation upon CC2238/AANP exposure in VSMCs (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Adeno-associated virus,adeno-associated virus 2,Homo sapiens,Mus musculus,Armoracia rusticana)
• Glucose deprivation (GD) affects c-MYC protein levels in a cell-type-dependent manner (2015, NA)
• Apoptosis pathway: (A) The different paths that a cell can take during the activation of cell death (2015, Homo sapiens)
• Mechanism linking excess fatty acids to insulin resistance in skeletal muscle (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Adipocytokines and Hepatic Fibrosis (2015, NA)
• Glucocorticoids Significantly Influence the Transcriptome of Bone Microvascular Endothelial Cells of Human Femoral Head (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Noradrenergic signaling stimulating glycogenolysis (A) or glycogen synthesis (B) (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• NFKB/p65 ubiquitination and degradation signaling (2015, NA)
• Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection (2015, Trypanosoma cruzi,Homo sapiens)
• Cell death pathway in tumor cells (2015, Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Bacillus anthracis,Mycobacterium tuberculosis variant bovis,Hepatitis B virus,Human papillomavirus,Homo sapiens,Mus musculus,Chironomus thummi,NA)
• Human dendritic cell (DC) response to Toll‐like receptor (TLR)2/3 adjuvants (2015, Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Bacillus anthracis,Mycobacterium tuberculosis variant bovis,Hepatitis B virus,Human papillomavirus,Homo sapiens,Mus musculus,Chironomus thummi,NA)
• Ethylene biosynthesis and transduction pathway (2015, NA)
• Ah Receptor Pathway Intricacies (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Mesocricetus auratus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Hepatitis B virus)
• Focal adhesion pathway analysis based on the KEGG database (2015, Homo sapiens,Rattus norvegicus,Streptococcus pyogenes)
• Targeted Lipidomic and Transcriptomic Analysis Identifies Dysregulated Renal Ceramide Metabolism in a Mouse Model of Diabetic Kidney Disease (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Age-related neuroinflammation and changes in AKT-GSK-3B and WNT/ Beta-CATENIN signaling in rat hippocampus (2015, NA)
• PTEN tumor suppressor gene and its role in lymphoma pathogenesis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Moloney murine leukemia virus)
• PTEN tumor suppressor gene and its role in lymphoma pathogenesis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Moloney murine leukemia virus)
• Simplified schematic summarizing the BMP signalling pathway and genes that have to date been shown to be mutated in PAH and demonstrating that many of these mutations encode protein involved in BMP signalling (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio,Diaporthe sclerotioides)
• Beta-Catenin participates in cadherin-mediated cell adhesion and is a transcriptional coactivator in the canonical Wnt signaling pathway (2015, NA)
• ATM-mediated DNA DSB repair pathway (2015, NA)
• Mitochondria-derived signaling pathways controlling muscle mass (2015, NA)
• Signaling pathways of IL-17A in synovial fibroblasts (2015, NA)
• Simplified diagram showing mechanisms involved in activation of the JNK pathway (2015, NA)
• Tetraspanins organize the T-cell immunological synapse (2015, Saccharomyces cerevisiae,Candida dubliniensis,Candida albicans,Cryptococcus neoformans,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Homo sapiens,Listeria monocytogenes,Triportheus paranensis,NA)
• PI3K/Akt pathway (2015, NA)
• Putative inhibitory pathway of macrophage-mediated inflammatory signaling responses, as suppressed by KTH-13-AD1 (2015, Candida albicans,Panax ginseng,Agaricus bisporus,Beauveria bassiana,Hopea odorata,Cerbera manghas,Escherichia coli,Vibrio vulnificus,Mycobacterium scrofulaceum,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Himerometra magnipinna)
• PI3K/Akt/mTOR (PAM) pathway and inhibitors of the pathway tested in phase I-III clinical trials on solid tumors and/or breast cancer (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Hepatitis B virus)
• Proposed role of ABHD6 in the late endosomal/lysosomal pathway (2015, Human immunodeficiency virus,Vesicular stomatitis virus,Semliki Forest virus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Capra hircus,Cannabis sativa,Homo sapiens,Opsanus beta)
• Working model for Gpr175 function as an enhancer of Hh signaling (2015, Mus musculus,Danio rerio,Chlorocebus aethiops,Homo sapiens)
• The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Dryas iulia)
• Chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells (2015, NA)
• Genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia (2015, Homo sapiens,Mus musculus,Xenopus laevis)
• Synthesis and immunomodulatory effect of gangliosides (2015, Homo sapiens,Mus musculus,Patella vulgata)
• CagA mediates dysregulation of the Wnt/Beta-catenin signaling pathway (2015, NA)
• Origin and in vitro generation of eCPCs (2015, NA)
• The core autophagy pathway and its regulation by miRNAs (2015, Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• Interactions between immunotherapy and targeted therapy (2015, NA)
• Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling (2015, Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Betapolyomavirus macacae,Human alphaherpesvirus 3,Murid herpesvirus 68,Mus musculus,Rattus norvegicus,Peromyscus sejugis,Armoracia rusticana,Diaporthe sclerotioides,Xenopus laevis,Calloplesiops altivelis,Homo sapiens,Oryctolagus cuniculus,vectors,Escherichia coli BL21,NA)
• Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Overexpression of E2F-2 abolishes the PPP-mediated inhibition of terminal differentiation in Gata1S310A erythroid cells ex vivo (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGFB Receptor Pathway in Human Aortic Endothelial Cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Human papillomavirus type 16)
• Canonical pathway of miRNA biogenesis (2015, Homo sapiens,Pan troglodytes,Mus musculus,NA)
• Downstream gene targets of predicted cytokine and transcriptional regulators (2015, NA)
• Cross-talks between TGFBsignaling pathway and TNFAsignaling pathway (target instance) (2015, NA)
• Reconstruction of TNFAsignaling pathway (target instance) (2015, NA)
• Reconstruction of TGFBsignaling pathway (target instance) (2015, NA)
• Reconstruction of Notch signaling pathway (target instance) (2015, NA)
• Signaling pathway of BDNF (2015, NA)
• miRNAs regulate cell metabolism by targeting key metabolic enzymes and multiple oncogenic signaling pathways (2015, NA)
• Molecular mechanisms linking ciliogenesis and cell cycle regulation (2015, Drosophila melanogaster,Lareunionomyces loeiensis,Dicranocarpus parviflorus,Appias albina,Homo sapiens,Mus musculus)
• Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy (2015, NA)
• Oncogenic miRNAs involved in the apoptotic pathway (2015, Homo sapiens,Mus musculus,Danio rerio,NA)
• Melanoma cells develop resistance to MAPK inhibitors by mutating (mut) or altering expression of a number of proteins which reactivate MAPK signaling and/or activate alternative survival pathways such as the PI3K pathway (2015, NA)
• Functional role of deubiquitinating enzymes in autophagy (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Vasconcellea candicans,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Functions of mono-ADP-ribosylating ARTD (ADP-ribosyltransferase diphtheria toxin-like) enzymes and of mono-ADP-ribosylating Sirtuins in signaling (2015, Hepatitis B virus,Sindbis virus,Human coronavirus 229E,Venezuelan equine encephalitis virus,Mus musculus,Rattus norvegicus,Staphylococcus aureus,Streptococcus pyogenes,Homo sapiens,Saccharomyces cerevisiae,NA,NA)
• Mitochondrial dysfunction caused by inhibition of pyruvate transfer to mitochondria (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Lactate dehydrogenase-elevating virus,NA)
• Antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells (2015, NA)
• Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism (2015, NA)
• Regulation of Bim in Health and Disease (2015, NA)
• Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2A/androgen receptor signals (2015, NA)
• STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation (2015, Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Erythrina poeppigiana,Homo sapiens,Mus musculus,Turdus migratorius)
• STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation (2015, Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Erythrina poeppigiana,Homo sapiens,Mus musculus,Turdus migratorius)
• The respective drug targets in the overall architecture of molecular interactions for the top pathways correlating with response to Pazopanib A (2015, Homo sapiens,Mus musculus,Bos taurus)
• By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Core of kinase-regulated interactomes defines the neoplastic MDSC lineage (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Diaporthe sclerotioides)
• C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model (2015, NA)
• MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model (2015, Homo sapiens,Mus musculus)
• Non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation (2015, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus)
• PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines (2015, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Thioredoxin 1 mediates TGF-Beta-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human papillomavirus,Dipturus trachyderma)
• Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy (2015, Homo sapiens)
• Mechanism of Butyrate Stimulation of Triglyceride Storage and Adipokine Expression during Adipogenic Differentiation of Porcine Stromovascular Cells (2015, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Moloney murine leukemia virus)
• Protein kinase C (PKC) involvement in cytoplasmic signal transduction pathways in the immune system (2015, NA)
• Proposed mechanism for zinc‐mediated inhibition of interleukin‐1B (IL‐1B) signalling and its role for repression of human T helper type 17 (Th17) responses (2015, NA)
• Monocytes from MS patients cluster independently from HV and display enhanced inflammatory pathways (2015, Homo sapiens,Rattus norvegicus,Human immunodeficiency virus 1,Trichuris suis)
• Gene‐by‐age interaction miRNA–mRNA network analysis (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Rheum tanguticum,Homo sapiens)
• Ubiquitination-mediated signaling cascades in canonical and non-canonical NFKB pathways (2015, NA)
• Toll-like receptors (TLR) 4-mediated signaling of innate immune responses (2015, NA)
• NFKB and STAT3 signaling pathway (2015, NA)
• Proposed model for Parkin-dependent and-independent mitophagy and mitochondrial spheroid formation in alcohol-induced mitochondrial damage and liver injury (2015, NA)
• Intracellular detection of viral RNA by PRRs and activation of the innate immune response (2015, NA)
• Prostaglandin biosynthesis pathways (2015, NA)
• Tailoring steroid-sensitive virus-specific T cells with TALEN (2015, NA)
• Processes affecting TOB1 levels and diverse mechanisms underlying TOB1 tumor suppression activity (2015, NA)
• Data upload to Parkinson´s disease (PD) map (June 2015 release) (2015, Mus musculus,Rattus norvegicus,gut metagenome,clinical samples,Homo sapiens,prion)
• Crucial role of miRNAs in coordinating vast prostate cancer (PC) metabolic processes (2015, NA)
• Curcumin blocks multiple cancer promoting pathways via miR-21 (2015, NA)
• Metabogenic and nutriceutical supplements to promote bioenergetical potential and moderate muscle wasting in DMD (2015, NA)
• The endocrine loops between bone and pancreas, and adipose tissue (2015, NA)
• Structure of the ELTD1 receptor (2015, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Sus scrofa,Phoenicopterus roseus,Alburnus alburnus,Homo sapiens)
• IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas (2015, NA)
• Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism (2015, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Sus scrofa domesticus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Pieris brassicae)
• Signalling pathways downstream of CCK‐8s in pancreatic beta cells (2015, Mus musculus,Homo sapiens)
• Local inhibition of miR‐24 in ECs would turn off apoptosis signalling pathway and improves reparative angiogenesis in post‐ischaemic conditions (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans,NA)
• Wilms' tumor 1 (WT1) contributes to metanephric mesenchyme self-renewal and its differentiation (2015, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• Myc coordinates transcription and translation to enhance transformation and suppress invasiveness (2015, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Nicotiana tabacum,Human immunodeficiency virus 1)
• Schema depicting the proposed mechanisms for MTMR14 deletion-induced obesity and complications (2015, NA)
• Schematic presentation of butein-mediated signaling transduction modulation (2015, NA)
• PPI human module (2015, NA)
• Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins (2015, Saccharomyces cerevisiae,Homo sapiens)
• Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators (2015, NA)
• Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regulators (2015, NA)
• Comparative Transcriptome Analysis in the Hepatopancreas Tissue of Pacific White Shrimp Litopenaeus vannamei Fed Different Lipid Sources at Low Salinity (2015, NA)
• Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases (2015, NA)
• Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases (2015, Homo sapiens)
• HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction (2015, NA)
• HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction (2015, NA)
• HMGB1-RAGE Inflammatory Pathway: Implications for Brain Injury-Induced Pulmonary Dysfunction (2015, NA)
• Terpenoid biosynthesis via the MEP pathway in engineered Synechocystis (2015, NA)
• Schematic summarizing some of the genes and pathways known to influence c-Myc cap-independent translation in multiple myeloma (MM) (2015, Homo sapiens,Human betaherpesvirus 5,Iris germanica)
• Signaling pathways leading to gonadotropin-induced activation of MAPK3/1 in preovulatory follicles or cultured cumulus-oocyte complexes (2015, Bos taurus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Signaling pathways activated by cytokine receptor binding (2015, Homo sapiens,Rattus norvegicus,Gallus gallus,Diaporthe sclerotioides)
• Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKB and CREB Pathways and Negative ERK1/2 Pathway (2015, NA)
• Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages (2015, Escherichia coli,Mycobacterium tuberculosis,Streptococcus mutans,Aggregatibacter actinomycetemcomitans,Escherichia coli O111B4,Apis mellifera,Cerobasis alpha,Melipona scutellaris,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Ligustrum vulgare)
• Expression of Lactate Dehydrogenase in Aspergillus niger for L-Lactic Acid Production (2015, NA)
• Computational Models Describing Possible Mechanisms for Generation of Excessive Beta Oscillations in Parkinson’s Disease (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Eucalyptus intertexta)
• Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Eucalyptus intertexta)
• Working model of the cellular pathways contributing to long-lasting phrenic motor facilitation triggered by intermittent hypoxia (2015, Homo sapiens)
• Insulin/IGF-1/FBS-mediated stimulation of D2 (2015, Mus musculus,Homo sapiens)
• How ER stress regulates SIRT1 expression (2015, Mus musculus,Homo sapiens)
• Canonical and non-canonical nuclear factor (NF)KB activation pathways (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Human immunodeficiency virus 1)
• Position-dependent regulation of cell fate in the preimplantation embryo: known and hypothetical mechanisms (2015, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus)
• Cytoprotective Effect of Hyperoside against Oxidative Stress Is Mediated by the Nrf2-ARE Signaling Pathway through GSK-3B Inactivation (2015, NA)
• MTORC1 signaling to the translational machinery (2015, NA)
• Complement activation, regulation, and molecular basis for complement‐related diseases (2015, NA)
• Transcription_P53 signaling pathway (2015, NA)
• DEGs involved in JNK pathway in Tg(RE:HSE:EGFP) (2015, Danio rerio,Opsanus beta,Homo sapiens,Mus musculus,Bos taurus,Prevotella sp.)
• Schematic representation of Slit-Robo signaling pathway in gastric tumorigenesisᅟ (2015, NA)
• Molecular mechanism underlying the anticancer effects of flavone, apigenin, and luteolin on the Akt/FOXO3a/p27 pathway in regulating human breast cancer cell proliferation (2015, Armoracia rusticana,Triticum aestivum,Malus domestica,Homo sapiens,Bos taurus)
• Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas (2015, Oryctolagus cuniculus,Capra hircus,Ornithorhynchus anatinus,Homo sapiens,Mus musculus,clinical samples)
• Signaling pathways activated by BCR-ABL (2015, NA)
• Long-Lived AMUPA Mice Show Attenuation of Cardiac Aging and Leptin-Dependent Cardioprotection (2015, Mus musculus,Rattus norvegicus,Capra hircus,Equus asinus,Homo sapiens)
• Oncogene Overdose: Too Much of a Bad Thing for Oncogene-Addicted Cancer Cells (2015, NA)
• Proteome Analysis of Ground State Pluripotency (2015, Saccharomyces cerevisiae,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Mus musculus,Bos taurus)
• Recruitment of HSCs in CML niche requires TGF-beta1 activated PI3K/Akt/NFKB/MMP9 signaling pathway (2015, NA)
• Metabolic networks placing mitochondria at the center of anabolic and bioenergetics pathways in cancer cells (2015, Homo sapiens,Mus musculus,clinical samples,NA)
• Proposed mechanisms of PARP1 activation in response to growth-inhibitory molecules (2015, NA)
• Proposed Model of TRAIL-Susceptiblity in Breast Tumour Subpopulations: (a) Epithelial-like cells have cytoplasmic cFLIP and consequently are resistant to TRAIL-mediated apoptosis (2015, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,clinical samples,Moloney murine leukemia virus,Dryas iulia,Morchella esculenta)
• Summary of the relationships between miR-214, UCP2, beclin-1, LC3-II, Bax, Caspase-9, PARP, and PI3K-Akt-mTOR after TAM/FUL treatment (2015, NA)
• Classical pathways of type I IFN induction and HCV mediating IFN resistance (2015, Non-A non-B hepatitis virus,Hepatitis C virus genotype 1,Hepatitis C virus subtype 3a,Oryza sativa,Citrus limon,Homo sapiens,Mus musculus,NA)
• Detail of the IL-6 signaling pathway (2015, NA)
• Schematic overview of the multifactor regulatory network involved in ethylene biosynthesis and signaling during fruit development and ripening (2015, Solanum lycopersicum)
• Genomic and transcriptomic features of central carbon metabolism in C (2015, Arabidopsis thaliana,Auxenochlorella pyrenoidosa)
• Survey of the Impact of Deyolking on Biological Processes Covered by Shotgun Proteomic Analyses of Zebrafish Embryos (2015, Danio rerio,Homo sapiens)
• FcGR-mediated phagocytosis pathway in the KEGG database is the putative pathway which is related to TNFA and TGFB1 expression in microglial cells (2015, Armoracia rusticana,Cryptococcus neoformans,Panax notoginseng,Jasminum officinale,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Molva molva,Leishmania major)
• Autophagic signaling pathways associated with oxidative stress (2015, Saccharomyces cerevisiae,Allium sativum,Punica granatum,Mus musculus,Rattus norvegicus,Ovis aries,Equus asinus x Equus caballus,Homo sapiens)
• Mechanism-based combinatorial experimental regimens aimed at disrupting known oncogenic cooperation pathways in ABC-DLBCLs (2015, Homo sapiens)
• Oncogenic (deregulated) intracellular signaling pathways in activated B cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) (2015, Homo sapiens)
• Oncogenic (deregulated) intracellular signaling pathways in germinal center B cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) (2015, Homo sapiens)
• Multi-Scale Agent-Based Multiple Myeloma Cancer Modeling and the Related Study of the Balance between Osteoclasts and Osteoblasts (2015, Leucanthemum maximum,Vandenboschia maxima,Homo sapiens,Rattus norvegicus,Bos taurus)
• Wnt/Beta-catenin signaling and directly related pathways affected by genetic-driven and/or gene expression activation or suppression in primary and/or recurrent tumors of 4 HCC patients (2015, Homo sapiens,Mus musculus,Hepatitis B virus,bacterium A3-1-1,NA,NA)
• Enhanced eNOS activation as the Fountain of Youth for Vascular Disease: Is BPIFB4 what Ponce de León was looking for? (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• is a pictorial representation of the intracellular insulin signaling pathway (2015, NA)
• Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians (2015, Homo sapiens)
• Development WNT signaling pathway Part 1 (2015, Homo sapiens,Mus musculus,Danio rerio,Sequoia sempervirens)
• Development Hedgehog Signaling which is the top scored pathway map in MetaCore enrichment analysis results (2015, Homo sapiens,Mus musculus,Danio rerio,Sequoia sempervirens)
• LRRK2 in neurons in Parkinson's disease which is the fifth scored pathway map in MetaCore enrichment analysis results (2015, Homo sapiens,Mus musculus,Danio rerio,Sequoia sempervirens)
• Cell cycle Role of SCF complex in cell cycle regulation which is the third scored pathway map in MetaCore enrichment analysis results (2015, Homo sapiens,Mus musculus,Danio rerio,Sequoia sempervirens)
• Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling (2015, NA)
• Serum Metabolomics to Identify the Liver Disease-Specific Biomarkers for the Progression of Hepatitis to Hepatocellular Carcinoma (2015, NA)
• Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs (2015, NA)
• Molecular mechanisms linking insulin resistance with neurodegeneration (2015, NA)
• Surviving at a distance: organ specific metastasis (2015, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Osteocytes and Skeletal Pathophysiology (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Human immunodeficiency virus 1)
• Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Human immunodeficiency virus 1)
• Simple feature construction method for predicting upstream/downstream signal flow in human protein-protein interaction networks (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Human immunodeficiency virus 1)
• Proposed GC-C signaling in colitis (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt signaling pathways (2015, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Lareunionomyces loeiensis,Melia azedarach,Homo sapiens,Canis lupus familiaris)
• Proposed schematic showing targets of SA transcriptional regulation of insulin signaling pathway (2015, Hunteria umbellata,Artocarpus hirsutus,Homo sapiens,Rattus norvegicus,Nymphalis l-album)
• Innate receptor signaling and stefin B influence NFKB activation and caspase-11 expression in macrophages (2015, NA)
• Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization (2015, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,NA)
• Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic (2015, Homo sapiens,Rattus norvegicus,Moloney murine leukemia virus)
• p53 attenuates AKT signaling by modulating membrane phospholipid composition (2015, Homo sapiens,Mus musculus,Bos taurus,Cystobasidium portillonense)
• Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer (2015, NA)
• Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Moloney murine leukemia virus,Merkel cell polyomavirus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• Cerebral endothelial cell function by TGFB in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition (2015, NA)
• ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma (2015, Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• TPL2 mediates IL-17R signaling in neuroinflammation (2015, NA)
• Regulation of T follicular helper cells by ICOS (2015, NA)
• Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells (2015, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Helicobacter pylori,Klebsiella pneumoniae,Haemophilus influenzae,Campylobacter jejuni,Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana,Moloney murine leukemia virus)
• Mechanisms underlying vernodalin-induced cytotoxicity in breast cancer cells (2015, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Nigella sativa,Cuminum cyminum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic of the proposed non-canonical Wnt signaling pathway induced in the ceca from experimental chickens with persistent colonization by Salmonella Enteritidis (2015, Salmonella enterica,Homo sapiens)
• MITF function in the nucleus of a melanosome to activate melanin synthesis and secretion and melanocyte growth and survival (2015, NA)
• Transcription factors and genes that regulate PDKs regulation (2015, NA)
• Feedback reactivation of MAPK signaling (2015, NA)
• MAPK signaling pathway in CRC (2015, NA)
• Profiling the role of mammalian target of rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension (2015, Homo sapiens)
• TGFB Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth (2015, Gallus gallus,Xenopus laevis,Oryzias latipes,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• A, B) Functional analyses of target genes of the differentially expressed miRNAs in MAPK signal pathway (2015, NA)
• Pharmacological agents to inhibit downstream signaling intermediated of GAq (2015, NA)
• LIF protects cardiac myocytes by both genomic and non-genomic means (2015, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Drosophila melanogaster)
• Molecular mechanisms underlying the oncogenic metabolic phenotype (2015, Homo sapiens)
• Predicted model for the action of GSK3B in buffalo embryonic stem ( ES ) cells (2015, Bubalus bubalis,Homo sapiens)
• BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer (2015, NA)
• Scheme of the metabolic effect in control and differentiated SH-SY5Y cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens)
• Phoenix Rising pathway of accelerated tumor repopulation (2015, NA)
• Schematic diagram illustrating the specific cascade and signalling pathway in LPS-primed macrophages stimulated with nanoparticles (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Escherichia coli,Corynephage beta)
• Diagram summarizes adaptive signaling pathways activated by CBD via ROS upregulation (PMT and antioxidant response, both reversible) in GSCs (2015, NA)
• Proposed model: importance of the miR-30 regulatory effects in cardiomyocytes following DOX exposure (2015, NA)
• Pyruvate branch pathway as defined by Hoefnagel et al (2015, Escherichia coli,Escherichia coli IS1,Lactococcus lactis,Mycoplasmoides genitalium,Lactococcus lactis subsp. lactis,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Mammalian “Obesogen” Tributyltin Targets Hepatic Triglyceride Accumulation and the Transcriptional Regulation of Lipid Metabolism in the Liver and Brain of Zebrafish (2015, NA)
• Model for CD44 action in logarithmic (growth-promoting mode) and confluent (growth-inhibitory mode) growth conditions (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Sonic Hedgehog Pathway (2015, NA)
• Multiple regulation pathways and pivotal biological functions of STAT3 in cancer (2015, Mus musculus,Rattus norvegicus,Silybum marianum,Cephalotaxus harringtonia,Homo sapiens,Drosophila melanogaster)
• Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway (2015, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• Signalling pathways and mechanisms regulated by vagal activation (2015, NA)
• Molecular events involving IRFs in immune responses (2015, NA)
• Possible hypothesis; two signaling pathways of LPS to induce motility disorder in intestinal smooth muscles (2015, NA)
• Hypothesis concerning cystic follicle (CF) formation in the pig (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Comprehensive illustration of transcription changes in skeletal muscle of red cusk-eel under handling stress using modified KEGG pathway maps using Pathvisio v3 (2015, NA)
• Signaling pathways of Sirt6 in the heart (2015, NA)
• Simplified pathway diagram showing the Leishmania-APC and T cell interaction (2015, Homo sapiens,Mus musculus,Human gammaherpesvirus 8,Prunus persica,Leishmania major)
• BCR signaling and downstream pathways (2015, Homo sapiens)
• Metabolic strategy in evolved strains lacking the aas-lplT operon (2015, Escherichia coli,Homo sapiens)
• Possible intracellular route of TDZ in human astrocytes (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Differentiation-coupled induction of HCMV replication via enhancer RARE, CRE, and kB in quiescently infected NT2 (2015, NA)
• Autophagic signaling pathway (2015, NA)
• Death receptor signaling pathway (2015, NA)
• Mitochondrial apoptotic pathway (2015, NA)
• Transcriptomes reveal the genetic mechanisms underlying ionic regulatory adaptations to salt in the crab-eating frog (2015, NA)
• Sulfur assimilation pathway and major sulfur metabolites (2015, Arabidopsis thaliana,Nicotiana tabacum,Solanum lycopersicum,Triticum aestivum,Brassica napus,Medicago truncatula,Manihot esculenta,Nicotiana attenuata,Eruca vesicaria subsp. sativa,Homo sapiens,Bacillus sp. B55)
• Possible actions of metabolic syndrome on glia-to-neuron communication mediated by hemichannels (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Xenopus laevis,Vasconcellea candicans)
• Mechanisms underlying tanshinone IIA-TRAIL synergy (2015, NA)
• Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade (2015, Human alphaherpesvirus 1,Human immunodeficiency virus,Japanese encephalitis virus,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Capra hircus,Listeria monocytogenes,Matthiola incana)
• Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway (2015, NA)
• Apoptosis induced by TRAIL (2015, NA)
• Drug target prioritization by perturbed gene expression and network information (2015, NA)
• The potential mechanisms by which AICAR regulates cardiac metabolism and protects HL-1 cardiomyocytes from the HP/HI-induced lipotoxicity and insulin resistance (2015, NA)
• Cyclin D1-cyclin-dependent kinase 4/6-retinoblastoma 1 pathway (2015, NA)
• Signaling network structure predicted by GA (upper) and the true underlying structure (lower) in the case of Leukocyte transendothelial migration pathway (2015, Escherichia coli,Escherichia coli IS1,Homo sapiens)
• Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma (2015, NA)
• Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus,vectors,Human adenovirus 5)
• Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma (2015, NA)
• Targeting cancer by binding iron: Dissecting cellular signaling pathways (2015, NA)
• Targeting cancer by binding iron: Dissecting cellular signaling pathways (2015, NA)
• Difference in expression of the calcium signaling pathway between rat neurons and OPCs grown in vitro (2015, NA)
• Mechanism of action of soy peptides in HepG2 cells (2015, NA)
• Intrinsic and extrinsic apoptotic pathways: The intrinsic, or mitochondrial, pathway is initiated from within the cell in response to DNA damage, loss of cell-survival factors and severe cell stress (2015, NA)
• ER stress sensors and Programmed Cell Death in animals (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Zea mays,Glycine max,Solanum tuberosum,Hordeum vulgare,Nicotiana benthamiana,Phytophthora infestans,Fusarium verticillioides,Serendipita indica,Pseudomonas syringae,Pseudomonas syringae pv. tomato str. DC3000,Xanthomonas oryzae pv. oryzae,Pseudomonas syringae pv. maculicola,Pseudomonas savastanoi pv. phaseolicola,Tobacco mosaic virus,Potato virus X,Turnip mosaic virus,Rice black streaked dwarf virus,Homo sapiens)
• The fate of chemoresistance in triple negative breast cancer (TNBC) (2015, Homo sapiens)
• Actin signaling pathways and their association with brain disorders (2015, NA)
• JNK1 exerts kinase activity on several transcription factors and BCL2 family proteins through phosphorylation or ubiquitination (2015, NA)
• Activation mechanisms of the ASK1 signaling pathway leading to JNK and p38MAPK phosphorylation (2015, NA)
• Activation mechanism of NRF2 and downstream transcription events (2015, NA)
• Proposed EPLIN signalling pathways and implications for loss in cancer (2015, NA)
• Biosynthesis pathway I (2015, NA)
• Relative functions and pathways in DN (2015, Homo sapiens,Rattus norvegicus,Armoracia rusticana,clinical samples)
• Differential proteins in acute phase signaling pathway in DN summarized in this and previous studies (2015, Homo sapiens,Rattus norvegicus,Armoracia rusticana,clinical samples)
• MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma (2015, NA)
• c-Met as a Target for Personalized Therapy (2015, NA)
• HGF-MET signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NFKB) leading to increases in cell survival, motility and proliferation (2015, NA)
• Network of interactions between GWAS candidate genes using ingenuity pathway analysis (IPA) (2015, Eimeria maxima,Homo sapiens)
• Insulin-like growth factor-1 signaling with regard to Helicobacter pylori associated glucose dysregulation (2015, NA)
• Cholesterol biosynthetic pathway and cholesterol synthesis inhibitors used in the current study (2015, Rattus norvegicus,Homo sapiens)
• Pathophysiology and management of CVD (2015, NA)
• Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NFKB Signaling (2015, Mus musculus,Cricetulus griseus,Cricetus cricetus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Escherichia coli BL21DE3,Homo sapiens,Armoracia rusticana,vectors)
• Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression (2015, NA)
• MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NFKB Signaling Pathway Following Negative Regulation (2015, NA)
• Normal complement cascade (2015, NA)
• Rac1 activation and Wnt synergistically enhance Beta-catenin transactivation in the canonical Wnt pathway (2015, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Wnt/Beta-catenin signaling pathway (2015, Homo sapiens)
• Amino acid metabolic pathways targeted in cancer therapy (2015, NA)
• Folate transport and folate mediated 1-carbon metabolism in eukaryotic cells (for gene abbreviations and enzyme commission numbers, see and , respectively) (2015, NA)
• Development of innate lymphoid cells (2015, NA)
• Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment (2015, NA)
• Characterization of FGF23-Dependent Egr-1 Cistrome in the Mouse Renal Proximal Tubule (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Oryctolagus cuniculus)
• Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer (2015, NA)
• NOX system is central to host defense (2015, NA)
• Regulation of endosomal trafficking (2015, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Murid betaherpesvirus 1,Human alphaherpesvirus 3,Human betaherpesvirus 6,Murid gammaherpesvirus 4,Human betaherpesvirus 7,Bovine alphaherpesvirus 1,Human adenovirus 2,Simian sarcoma-associated virus,Equid alphaherpesvirus 1,Equid alphaherpesvirus 4,Murid betaherpesvirus 2,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Equus caballus,NA)
• Graphical representation of activation of the JNK signaling pathway in SMA (2015, Mus musculus,Homo sapiens)
• Action of BRAF and MEK inhibitors in the MAP kinase signalling pathway (2015, NA)
• Model showing the molecular mechanism for the upregulation of AMPA receptors in the ACC of IBS animal model (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Oryctolagus cuniculus)
• Proposed schematic representation showing the mechanism of ETH and its effect on neurogenesis (2015, NA)
• Simplified schematic overview of the MAPK and PI3K signaling pathway (2015, NA)
• Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells (2015, NA)
• Network overview of the biomarkers in lung cancer and ALL (2015, NA)
• Linear Motifs in T cell receptor signalling pathway hsa04660 (2015, NA)
• Comparison of gene networks affected by ozone exposure in males and females (2015, NA)
• Ingenuity Pathway Analysis for inflammatory gene expression in females vs (2015, NA)
• TLR4 signaling in obesity (2015, Lactiplantibacillus plantarum,Lactobacillus acidophilus,Lacticaseibacillus paracasei,Lactobacillus gasseri,Lactobacillus acidophilus NCFM,Lactococcus plantarum,Latilactobacillus curvatus,Mus musculus,Rattus norvegicus,gut metagenome,human gut metagenome,Homo sapiens,Drosophila melanogaster,Moolgarda engeli,Fraxinus berlandieriana)
• Wnt-/-Beta-catenin signaling pathway (2015, NA)
• Working figure of the angiogenesis pathway genes (2015, Homo sapiens)
• Biophysical Approaches for Oral Wound Healing: Emphasis on Photobiomodulation (2015, NA)
• TRPV1 antagonist-induced hyperthermia involves BAT-mediated thermogenesis (2015, NA)
• Receptor tyrosine kinases and their targeted therapies in gastroesophageal cancers: EGFR, VEGFR and MET (2015, NA)
• Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling (2015, NA)
• During normal cellular conditions, BRD4 recognizes acetylated lysine residues on histones and recruits positive transcription elongation factor b (P-TEFb) to promote transcriptional elongation by RNA polymerase II of key oncogenic drivers such as MYC (2015, NA)
• NeurimmiRs were found targeting multiple molecules of the integrin and NFKB pathway (2015, Crassostrea gigas,Homo sapiens)
• Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice (2015, Influenza A virus,unidentified influenza virus,Orthomyxoviridae,H1N1 subtype,Human gammaherpesvirus 8,H5N1 subtype,Murid betaherpesvirus 1,Human alphaherpesvirus 3,H7N9 subtype,H5N2 subtype,H5N8 subtype,H5N5 subtype,H11N9 subtype,Gallus gallus,Meleagris gallopavo,Anas platyrhynchos,Homo sapiens,Mus musculus,Sus scrofa,Sequoia sempervirens)
• Dynamic changes in host gene expression associated with H5N8 avian influenza virus infection in mice (2015, Influenza A virus,unidentified influenza virus,Orthomyxoviridae,H1N1 subtype,Human gammaherpesvirus 8,H5N1 subtype,Murid betaherpesvirus 1,Human alphaherpesvirus 3,H7N9 subtype,H5N2 subtype,H5N8 subtype,H5N5 subtype,H11N9 subtype,Gallus gallus,Meleagris gallopavo,Anas platyrhynchos,Homo sapiens,Mus musculus,Sus scrofa,Sequoia sempervirens)
• CTGF Signaling Network ModelWe compiled a list of molecules known to be associated with hematopoiesis () and reported to interact directly or indirectly with CTGF and each other using EXERBT text mining and Pathway Commons, respectively ( and ) (2015, NA)
• Glycerol biosynthesis in respond to osmotic stress and redox statue and the interrelationship with yeast-derived aroma compounds in S (2015, NA)
• Enriched pathway of Integrin (A) and migration (B) (2015, Homo sapiens)
• Schematic mechanisms of action for drugs involved in the three arms of the TORAVA trial (2015, Homo sapiens)
• Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network (2015, NA)
• Investigation of Pathogenic Genes in Chinese sporadic Hypertrophic Cardiomyopathy Patients by Whole Exome Sequencing (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Diaporthe sclerotioides)
• Canonical and noncanonical NFKB signaling pathways (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Differentially expressed genes in the cytokine-cytokine receptor interaction pathway (ko04060) (2015, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Equus caballus,Escherichia coli,Streptococcus equi subsp. zooepidemicus,Trueperella pyogenes,Mus musculus,Rattus norvegicus,Homo sapiens)
• Differentially expressed genes in the toll-like receptor signalling pathway (ko04620) (2015, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Equus caballus,Escherichia coli,Streptococcus equi subsp. zooepidemicus,Trueperella pyogenes,Mus musculus,Rattus norvegicus,Homo sapiens)
• Some metabolic pathways and pathways implicated in virulence and repair mechanisms induced in vivo compared to in vitro cultivation (2015, NA)
• Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics (2015, Homo sapiens,Mus musculus,Bos taurus,Human gammaherpesvirus 4)
• Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway (2015, NA)
• Comprehensive MicroRNA Expression Profile Related to Hypoxia Adaptation in the Tibetan Pig (2015, Bos taurus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Rattus norvegicus,Homo sapiens subsp. Denisova,Gallus gallus)
• Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling (2015, Homo sapiens,Mus musculus)
• Biosynthetic genes responsible for polyketide extender units of RM-A (2015, NA)
• The signaling pathways involved in GnRH-induced ERK activation (red arrows) and ErbB4 cleavage (blue arrows) (2015, NA)
• Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway (2015, Mus musculus,Homo sapiens)
• Schematic overview of M1 protein-induced IL-8 expression in human keratinocytes (2015, NA)
• Proposed mechanism for SCG2 expression in HSV- and reovirus-infected cells (2015, NA)
• Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Angelica sinensis,Trifolium pratense,Homo sapiens,Danio rerio)
• Glatiramer acetate treatment negatively regulates type I interferon signaling (2015, NA)
• Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac ischemia/reperfusion (2015, NA)
• Interplay of TrkB and GR signaling pathways in the CNS (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Oryza sativa)
• Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression (2015, NA)
• Androgen receptor activation pathways (2015, NA)
• Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States (2015, NA)
• Dietary phytochemical alters caste-associated gene expression in honey bees (2015, NA)
• Novel role of miR-33 in regulating of mitochondrial function (2015, NA)
• Differential and interactive roles of PKC isoforms in mast cells (2015, Mus musculus,Rattus norvegicus,Cerobasis alpha,Acanthocheilonema viteae,Homo sapiens,Salmonella enterica subsp. enterica serovar Minnesota)
• Ingenuity pathway analysis (IPA) revealed a key role for the Molecular Mechanisms of Cancer set of pathways (2015, NA)
• Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus caballus,Saccharomyces cerevisiae,Human papillomavirus type 16,Sequoia sempervirens,Moloney murine leukemia virus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Differential Gene Expression Profiles and Selected Cytokine Protein Analysis of Mediastinal Lymph Nodes of Horses with Chronic Recurrent Airway Obstruction (RAO) Support an Interleukin-17 Immune Response (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus caballus,Saccharomyces cerevisiae,Human papillomavirus type 16,Sequoia sempervirens,Moloney murine leukemia virus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli (2015, Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis H37Rv,Mycobacterium avium,Mycobacterium tuberculosis variant bovis AF212297,Bos taurus,Felis catus,Homo sapiens,Rattus norvegicus,Sequoia sempervirens)
• Suggested model on key paths and determinants of resistance of P (2015, Penicillium janthinellum,Homo sapiens)
• Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity (2015, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Xenopus laevis)
• Thrombin-stimulated S1P secretion in human platelets (2015, NA)
• Coagulation proteases thrombin and activated factor X (FXa) enhance S1P synthesis and release from vascular smooth muscle cells (VSCMs) (2015, NA)
• Systematic autoimmune activation in RA (2015, NA)
• Summary of the roles of alpha-synuclein and other PD-associated proteins in the secretory pathway and the resulting stress responses (2015, NA)
• Signaling pathways involved in the inhibition of EMT by CHBP (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Etomidate on the Steroidogenesis of Rat Immature Leydig Cells (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Moloney murine leukemia virus)
• Speculative mechanism involved in the detrimental effect induced by the CX3CL1/CX3CR1-mediated microglial activation in the brain of ischemic mice (2015, NA)
• Human mesenchymal stem cell-engineered hepatic cell sheets accelerate liver regeneration in mice (2015, NA)
• Pathway analysis highlights APP is a central hub interacting with nearly 40% of candidate molecules in EGS (2015, Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Ovis aries,Equus caballus,Felis catus,Lama glama,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,prion)
• Schematic depicting how PC1/3 knockdown impacts macrophage activation based on the data presented in – (2015, NA)
• Novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway (2015, NA)
• Metabolomics study delineating geographical location-associated primary metabolic changes in the leaves of growing tobacco plants by GC-MS and CE-MS (2015, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Triticum aestivum,Hordeum vulgare,Prunus persica,Nicotiana suaveolens,Escherichia coli,Escherichia coli IS1,Homo sapiens,Rattus norvegicus)
• Anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients (2015, NA)
• Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts (2015, NA)
• Systemic Problems: A perspective on stem cell aging and rejuvenation (2015, NA)
• Kelch-like chicken erythroid-derived cap “n” collar homology factor-associated protein 1- (Keap1-) NF-E2-related factor 2- (Nrf2) antioxidant response element (ARE) signaling pathway (2015, Nicotiana tabacum,Zea mays,Brassica oleracea,Sinapis alba,Brassica oleracea var. italica,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Schematic presentation of a model highlighting the probable mode of action of AMA on placental development (2015, NA)
• Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells (2015, NA)
• Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis (2015, NA)
• T cell receptor signaling pathway showing downstream mediators regulated by DNA methylation, gene/protein expression and/or protein phosphorylation (2015, NA)
• Proteins used in this study (2015, NA)
• Structural Characterisation of FabG from Yersinia pestis, a Key Component of Bacterial Fatty Acid Synthesis (2015, Yersinia pestis,Homo sapiens)
• Heme metabolism and HO-1 enzyme activity (2015, Saccharomyces cerevisiae,Drosophila melanogaster,Apis mellifera,Vicia faba,Artemia franciscana,Eucalyptus gunnii,Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Human immunodeficiency virus 1,prion)
• Summary and model (2015, Arabidopsis thaliana)
• Nutrient, growth factor, and energy sensing impinge on the mTOR pathway (2015, Homo sapiens)
• Mechanistic model for irradiation-dependent and GSK3Beta-related signaling in HNSCC cells: Activated and inactivated molecules are displayed in green and in red, respectively (2015, Homo sapiens)
• Activated and aggressive CD4+T cell soldiers convert to spies (2015, Mus musculus,Homo sapiens)
• Induction of cell lines of spy cells into functionally distinct Treg lines (2015, Mus musculus,Homo sapiens)
• Induction of soldiers into functionally distinct cell lines (2015, Mus musculus,Homo sapiens)
• Activation of effector and regulatory T cells by antigen presenting cells (2015, Mus musculus,Homo sapiens)
• Mechanisms through which microRNAs (miRNAs) implicated in the TGFB signaling pathway in the lung epithelial cells and fibroblasts (2015, NA)
• Schematic diagram showing the possible consequences of SLC7A3 dysfunction on the mTOR and NO pathways (2015, NA)
• Inflammasome axis (2015, Homo sapiens,Nicotiana tabacum,Aggregatibacter actinomycetemcomitans)
• Constitutive control of AKT-1 gene expression by JUNB / CJUN in ALK+ anaplastic large cell lymphoma: a novel crosstalk mechanism (2015, NA)
• Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet (2015, Armoracia rusticana,Glycine max,Camellia sinensis,Theobroma cacao,Taraxacum officinale,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens)
• Complexity of microenvironment-mediated drug resistance (2015, NA)
• Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular complexes involved in the calcium signaling pathways responded to BPS and WEX treatments (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Sequoia sempervirens)
• Molecular complexes involved in the integrin-linked kinase signaling pathway responded to BPS and WEX treatments (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Sequoia sempervirens)
• AII-associated ROS pathway and alternation of the structure and function in cardiomyocyte (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,Vasconcellea candicans)
• Sources of ROS in the diabetic heart (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,Vasconcellea candicans)
• Schema of osteogenic differentiation through the BMP signaling pathway and possible regulation by PARP activity (2015, NA)
• Possible involvement of candidate microRNAs in tamoxifen resistance pathways, based on the present literature search and IPA analysis (2015, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Tamoxifen pathway and possible mechanisms of endocrine resistance in breast cancer cells (2015, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Simplified possible molecular signaling pathways (1 to 6) of estrogen (E) and estrogen receptors (ER) (2015, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Single network includes most splice regulatory genes dysregulated in MS (2015, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Epi regulatory pathway on BAG3 expression (2015, NA)
• Diagram of signaling pathway for genistein-induced apoptosis in Bax and p53-independent manner (2015, NA)
• Designs for the co-utilization of methanol and carbon dioxide towards (A) 3-hydroxybutyrate (B) 2-ketoisovalerate and (C) phloroglucinol (2015, Escherichia coli,Corynebacterium glutamicum,Escherichia coli str. K-12 substr. MG1655,Bifidobacterium adolescentis,Moorella thermoacetica,Clostridium ljungdahlii,Homo sapiens,Saccharomyces cerevisiae)
• Nodes-and-connections strategy generating an interaction map of signaling molecule network required for the fulvestrant-induced MCF-7 cell apoptosis (2015, NA)
• CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Dipturus trachyderma)
• In the classic or genomic pathway, androgens can move in the cytoplasm, where they bind to the AR (2015, NA)
• Left: the PI3K/AKT/mTOR pathway is mainly activated by nutrients (not shown) and growth factors, binding to receptor tyrosine kinases and activating PI3K (2015, NA)
• Death resistance signaling in cancer cells (2015, NA)
• Activation of PPARG by bioactive lipids can modulate signaling in progressive colorectal cancer (2015, NA)
• PI3K/PTEN/Akt/mTOR-cascade (Modified according to Cingarlini et al and McCubrey et al) (2015, NA)
• Integral extracellular signal-regulated kinase/mitogen-activated protein kinase pathway (2015, NA)
• HIF-signalling system and zebrafish homologues (2015, Homo sapiens,Danio rerio)
• Gene regulatory networks involved in photoreceptor development (2015, NA)
• The interaction between corneal stroma (canonical Wnt signaling) and epithelium (Bmp4 signaling) during mouse corneal development (2015, Homo sapiens,Mus musculus)
• Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation (2015, Oryza sativa,Solanum lycopersicum,Malus domestica,Mononeuria minima,Human gammaherpesvirus 4,Macacine gammaherpesvirus 4,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,cellular organisms)
• Reg IV activates the EGFR/Akt/AP-1 signaling pathway (2015, Homo sapiens,Mus musculus,Tropicoporus linteus)
• Canonical Wnt signaling pathway (2015, Homo sapiens,Mus musculus)
• Possible mechanism for the inhibition of EGFR/Raf1/ERK and IGF1R/PI3K/Akt signalling pathways by GEFITINIB and miR-7 co-treatment (2015, NA)
• Insulin/insulin-like growth factor signaling (IIS) and target of rapamycin pathway (TOR) pathways (2015, NA)
• Signaling pathways of main checkpoints molecules (2015, NA)
• Schematic overview of TLR and NLR signaling pathways (2015, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Bacillus subtilis,Listeria monocytogenes,Enterococcus faecalis,Porphyromonas gingivalis,Campylobacter jejuni,Streptococcus mutans,Mycoplasmopsis fermentans,Bartonella bacilliformis,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Vesicular stomatitis virus,Encephalomyocarditis virus,Entamoeba gingivalis,Homo sapiens,Candida albicans)
• Proposed mechanism for NFKB signaling inhibition mediated by the antitumor peptide CIGB-552 (2015, NA)
• Proposed model (2015, NA)
• Canonical pathway and gene network analysis of the 26 identifiers that were expressed in the lungs of PQ-treated rats (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Sequoia sempervirens,Euterpe oleracea,Homo sapiens,Canis lupus familiaris,Cerobasis alpha)
• Canonical pathway and gene network analysis of the 18 identifiers that were expressed in the lungs of PQ-free rats (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Sequoia sempervirens,Euterpe oleracea,Homo sapiens,Canis lupus familiaris,Cerobasis alpha)
• Proposed p53 signaling pathway in PQ-treated rat lungs (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Sequoia sempervirens,Euterpe oleracea,Homo sapiens,Canis lupus familiaris,Cerobasis alpha)
• Pyruvate and octanoate metabolism in the liver (2015, NA)
• EGFR and its signal pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Moolgarda engeli,NA)
• HIF-1A inhibitors modulate different levels of the HIF-1A activation pathway (2015, NA)
• Regulation of HIF-1A pathway at different levels (2015, NA)
• Representative HIF-1A regulatory genes and their effects on cancer progression (2015, NA)
• Roles of FXR in regulating lipid and glucose metabolism (2015, NA)
• Divergent macrophage activation pathway (2015, NA)
• Pathways of NADH production during glucose combustion (2015, NA)
• Fate of glucose (2015, NA)
• Changes in genes encoding components of the glycolytic, TCA cycle, and mitochondrial NADH shuttle pathways in gastrocnemius muscle in response to BCATm KO (2015, Mus musculus,Homo sapiens)
• BCATm KO on protein synthesis pathways (2015, Mus musculus,Homo sapiens)
• Networks predicted by Ingenuity Pathway Analysis in Cmah-null mice (2015, NA)
• Regulation of hypoxia-inducible factor-1 (HIF-1) expression and function by multiple inputs (2015, NA)
• Heme biosynthetic pathway in erythroid cells (2015, NA)
• Pathways analysis of the proteins listed in by means of the Ingenuity software (2015, Diaporthe sclerotioides,herbal medicine,Echinacea purpurea,Bidens pilosa,Homo sapiens,Mus musculus,Bos taurus)
• Proposed model of the role of TOX in innate lymphoid cell development (2015, NA)
• Schematic representation of the brain microvasculature features and corresponding Impact of TS (2015, NA)
• Schematic diagram (2015, NA)
• Diagrammatic representation of the signaling in abiotic stress and microtubule responses (2015, NA)
• Pathways activated by HDL in skeletal muscle that modulate glucose metabolism (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cytokine receptor interaction network for GBM survival (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Vibrio cholerae)
• p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Panthera leo,Enterobacteria phage A549)
• Enzymes involved in PGE2 synthesis and metabolism (2015, NA)
• Proposed model of cell wall lipid reorganization in M (2015, NA)
• Function of bacterial actin nucleators during infection (2015, NA)
• B‐Adrenergic modulation of skeletal muscle contraction: key role of excitation–contraction coupling (2015, Homo sapiens)
• Pathway network analyses on upregulated genes from late stage (stage IIIc) TNBC (2015, Homo sapiens,Sequoia sempervirens)
• Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Camellia sinensis)
• Tubulin folding cofactor D (TBCD) cooperates with Dscam during neuronal morphogenesis.(A, B) Schemes of wild-type (A) and TBCD mutant (B) projection neurons (2015, Homo sapiens,Mus musculus,Drosophila melanogaster,Agaricus bisporus)
• Ceramide is the hub of sphingolipid metabolism (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Caenorhabditis elegans,NA)
• MAMP (microbe-associated molecular pattern)-induced cellular signaling (2015, NA)
• Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Sequoia sempervirens)
• Proposed model illustrating the multiple signaling pathways by which PGRN (Atsttrin as well) exerts its anti-inflammatory actions (2015, NA)
• Biomarkers of Angiogenesis in Colorectal Cancer (2015, NA)
• Proposed mechanisms by which lycopene prevents oxidative stress in MSCs (2015, NA)
• Wnt pathway activation and ABCB1 expression account for attenuation of Proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells (2015, Homo sapiens)
• TGFB1-Smad3 pathway regulation in aged microglia (2015, NA)
• Reciprocal regulation of TGFB and Jak-Stat signaling (2015, NA)
• Regulation of Janus activated kinase (JAK)-Stat and nuclear factor kappa B (NFKB) signaling by TGFB through MKP-1 (2015, NA)
• Transforming growth factor B (TGFB) signaling pathways and aging (2015, NA)
• Duplicitous signaling roles of IL-6 (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Summary of protein and metabolites data at t = 8 h (2015, Arabidopsis thaliana,Homo sapiens)
• Novel Therapeutic Strategy: MEK Inhibitors to Treat cAMP-Mediated AnxietySchematic for the repositioning of MEKi as novel therapeutics for PDE4 blockade/AC activation anxiety (2015, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Armoracia rusticana)
• The GAq and GAs pathways that regulate neurotransmitter secretion in C (2015, NA)
• GA biosynthetic pathway (2015, Zea mays)
• Epigenetic regulators as central components in melanoma signaling (2015, NA)
• Pathways that play important roles in melanocyte and melanoma development (2015, NA)
• PIK3/AKT/mTOR signaling pathway in acute myeloid leukemia (2015, Homo sapiens)
• LRH-1 action in gastrointestinal tumor formation (2015, NA)
• Canonical Wnt/Beta-catenin signaling pathway: OFF state (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Camelus bactrianus,Lama glama,Homo sapiens,Mus musculus,Escherichia coli,Human immunodeficiency virus 1,Xenopus laevis,Lareunionomyces loeiensis,vectors)
• Mechanism that result in aberrant Wnt/Beta-catenin signaling in colon cancer (2015, NA)
• Programmed cell death in plants: A chloroplastic connection (2015, NA)
• D receptor‐mediated ERK1/2 activation via the PKCD/EGFR/B‐arrestin2 signalling pathway in response to specific agonist stimulation (2015, Rattus norvegicus,Homo sapiens)
• STRING network analysis reveals a database of known and predicted protein interactions (2015, NA)
• Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder (2015, NA)
• Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma (2015, Homo sapiens,Mus musculus,Bos taurus,Nicotiana tabacum)
• Putrescine in neuron and Schwann cell responses (2015, NA)
• Hypothesized model for E4-ORF1-induced constitutive Myc protein expression mediated by EGFR, InsR/IGF1R, and PI3K (2015, NA)
• Common cellular processes important in coronavirus replication (2015, Homo sapiens,Coronaviridae,Chlorocebus aethiops,Infectious bronchitis virus)
• Graphical summary: DNA repair proteins such as DNA-PKcs can be targeted to improve outcomes for patients with ovarian cancer (2015, Mus musculus,Cricetulus griseus,Homo sapiens,Human alphaherpesvirus 1,NA)
• Core signaling pathways in embryonic stem cells and cancer stem cells (2015, NA)
• Proposed mechanisms of TIE inhibition of LPS plus IFNG induced inflammation in RAW264.7 cells (2015, NA)
• Molecular pathways activated by inflammatory cytokines and growth factors and affected by MPN-associated mutations (2015, Hepatitis B virus,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Human betaherpesvirus 6,Helicobacter pylori,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia psittaci,Homo sapiens,Mus musculus,Nicotiana tabacum,human metagenome,Opisthorchis viverrini,NA)
• Main molecular pathways activated for the production of inflammatory cytokines (2015, Hepatitis B virus,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Human betaherpesvirus 6,Helicobacter pylori,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia psittaci,Homo sapiens,Mus musculus,Nicotiana tabacum,human metagenome,Opisthorchis viverrini,NA)
• Signaling pathway of angiotensin-II type 1 leading to superoxide production (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Armoracia rusticana,Syzygium cumini,Mus musculus,Rattus norvegicus,Homo sapiens)
• Structure-Activity Relationship of Synthetic 2-Phenylnaphthalenes with Hydroxyl Groups that Inhibit Proliferation and Induce Apoptosis of MCF-7 Cancer Cells (2015, NA)
• Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer Cells (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus)
• Parallel activin and TGFB signaling in advanced colon cancer (2015, Homo sapiens,Mus musculus,Bos taurus)
• DDVP profoundly affects energy metabolism (2015, Danio rerio,Homo sapiens)
• Putative interactions and feedback loops in the MAPK and PI3K/mTOR signaling cascades (2015, NA)
• MAPK signaling pathway in CNVRs unique to the susceptible line (2015, NA)
• Axon Regeneration Is Regulated by Ets–C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Saccharomyces cerevisiae IR-2,Homo sapiens,Oryctolagus cuniculus,Danio rerio,vectors)
• Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Vulture-specific genetic change in immune system (2015, NA)
• Kyoto Encyclopaedia of Genes and Genomes (KEGG) annotated the Toll-Like Receptor Signalling Pathway as significantly enriched in the RNA-seq dataset for HC (2015, NA)
• Metabolic pathways changed by pathway engineering in this study (2015, NA)
• Overshoot during phenotypic switching of cancer cell populations (2015, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• LncRNA mediated non-canonical Hh pathway (2015, Homo sapiens)
• Aberrant activation of alveolar epithelial cells (AECs) in lung fibrosis (2015, NA)
• Proposed mechanism of cordycepin-induced apoptosis and cell cycle arrest in NB-4 and U937 cells (2015, NA)
• Mitoribosome assembly lines (2015, Homo sapiens,Saccharomyces cerevisiae)
• Different regulation of DSB repair pathways in somatic cells and XY body (2015, NA)
• Cells express exosomes comprising lipids however lipids impact on cancer cells according to cell phenotype (2015, Homo sapiens)
• Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus (2015, Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Homo sapiens,Rattus norvegicus,Sequoia sempervirens,Dipturus trachyderma)
• Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus (2015, Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Homo sapiens,Rattus norvegicus,Sequoia sempervirens,Dipturus trachyderma)
• Driver genetic lesions in papillary thyroid carcinoma (2015, Homo sapiens)
• Cyclins and CKIs regulate cell motility (2015, Mus musculus,Homo sapiens)
• Mechanism of EMT induction derived from signaling network analysis validated in the mouse model (2015, NA)
• Genome of the facultative scuticociliatosis pathogen Pseudocohnilembus persalinus provides insight into its virulence through horizontal gene transfer (2015, Pseudocohnilembus persalinus,Homo sapiens)
• Mutations in PI3K, PTEN and AKT have dual effects on neuronal development leading to the formation of HMEG and FCD (2015, NA)
• Proposed model on how the WWP-1/UBC-18 complex modulates both stress response and dietary restriction pathways (2015, Caenorhabditis elegans,Homo sapiens)
• Updated model showing the role of AMPK-HDAC5 in HIF-1 activation as a response to hypoxia (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Homo sapiens,Caenorhabditis elegans,Carassius auratus)
• mTORC1 signaling pathway (2015, NA)
• Working models for the failure of PRL-PRLR-JAK2-STAT5 signaling to activate proliferation in adult human Beta-cells (2015, NA)
• The regulation of Hippo and Notch by Lgl (2015, NA)
• RASSF1A regulation of the Hippo pathway in response to DNA damage (2015, NA)
• RASSF1A/LATS1/CDK2 pathway upon fork stalling (2015, NA)
• MAPK/JNK signalling: a potential autophagy regulation pathway (2015, NA)
• Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress (2015, Homo sapiens,Mus musculus)
• Repurposing metformin: an old drug with new tricks in its binding pockets (2015, NA)
• Signalling to eIF4E in cancer (2015, NA)
• Proposed schematic illustration of the mechanism by which ACh exerts its endothelial protective effects against H/R injury in the present study (2015, NA)
• Glutamine deprivation induces cell death or growth arrest (2015, NA)
• Schematic diagram showing the mechanisms underlying the anti-cancer effects of Poncirin (2015, Armoracia rusticana,Allium cepa,Lonicera japonica,Paeonia suffruticosa,Houttuynia cordata,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• PI3K-independent AKT activation in cancer (2015, NA)
• Negative feedback loops in the PI3K/AKT pathway (2015, NA)
• AKT-independent PI3K signaling in cancer (2015, NA)
• PI3K/AKT signaling pathway (2015, NA)
• CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Quantitative analysis of transcriptional levels of genes in the xylose metabolic pathway and the central carbon metabolism pathway (2015, NA)
• YAP promotes cancer cell survival and resistance to RAF-MEK-targeting agents (2015, NA)
• Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging (2015, NA)
• Metabolic reconstruction of the Bathymodiolus symbiont (2015, Escherichia coli,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Vibrio cholerae,Bacillus subtilis At2,Synechocystis sp. PCC 6803,Synechocystis sp.,Yersinia pestis,Aliivibrio fischeri,Vibrio vulnificus,Rhizobium leguminosarum,Bordetella pertussis,Sodalis glossinidius,Bordetella bronchiseptica,Candidatus Hamiltonella defensa,sulfur-oxidizing symbionts,Mycetohabitans rhizoxinica,endosymbiont of Riftia pachyptila,Mycetohabitans endofungorum,Sinorhizobium sp.,Candidatus Ruthturnera calyptogenae,Paraburkholderia phenoliruptrix BR3459a,Chlorochromatium aggregatum,Xenorhabdus poinarii,Candidatus Endonucleobacter bathymodioli,Pinna nobilis,Mytilus edulis,Euprymna scolopes,Pinctada fucata,Riftia pachyptila,Sipunculus nudus,Bathymodiolus azoricus,Dreissena polymorpha,Tevnia jerichonana,Calyptogena magnifica,Solemya velum,Bocageia sp.,Bathymodiolus puteoserpentis,Bathymodiolus sp.,Toxolasma parvum,Heteractis magnifica,Perna perna,Armoracia rusticana,Oryza sativa,Erythrina poeppigiana,Rhizopus microsporus,Trachipleistophora hominis,Mimosa flocculosa,metagenome,metagenomes,Homo sapiens,Ovis aries,Neacomys sp.,NA)
• miRNA participation in TGFB signaling pathway in systemic sclerosis (2015, Homo sapiens,Mus musculus,Hepatitis B virus)
• Genes and pathways identified from GWAS and/or studies of monogenic allergy-related diseases (2015, Homo sapiens,Mus musculus,Catopsilia pomona,Rhinovirus C)
• Multiple activating human natural killer (NK) cell receptors and representative signalling pathways of 2B4, NKG2D, DNAM-1 and NKp46/30 (2015, NA)
• Model depicting the functional interplay between PPM1G, the 7SK snRNP, and ATM kinase during the activation of the NFKB transcriptional program in response to DNA damage (2015, NA)
• MAPK signaling pathway (2015, NA)
• The Wnt signaling pathway with selected inhibitors (2015, NA)
• Stomaching Notch (2015, NA)
• EGFR and ANXA3 to fluoropyrimidine resistance in fluoropyrimidine-treated gastric cancer patients (2015, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• Equivalent Gene Expression Profiles between Glatopa™ and Copaxone® (2015, NA)
• RNR regulation in S (2015, NA)
• Schematic view of the LPS-mediated NFKB pathway (2015, NA)
• Metabolic differentiation of the A, SS and FS types (2015, Escherichia coli,Escherichia coli IS1,Escherichia coli REL606,Homo sapiens,Saccharomyces cerevisiae,Bacteriophage sp.,Calloplesiops altivelis,environmental samples,cellular organisms)
• Extracellular adenosine-induced apoptosis of gastric cancer cells (2015, NA)
• Spindle assembly checkpoint and error correction (2015, NA)
• BaP effects on the expression of BaP marker genes and genes involved in the AHR signaling pathway (2015, Danio rerio,Homo sapiens)
• Outline of tlr signalling pathway (2015, Homo sapiens)
• Programmed death-1 causes T cell exhaustion (2015, NA)
• Wnt/Beta-catenin signaling pathway in high glucose condition (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,Musa ABB Group)
• Crosstalk between signaling pathways that lead to colorectal cancer progression (2015, NA)
• Expression and function of the insulin/IGF system in normal and colorectal cancer cells (2015, NA)
• PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,clinical samples)
• Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver (2015, Mus musculus,Rattus norvegicus,Armoracia rusticana,Olea europaea,Homo sapiens,Oryctolagus cuniculus)
• The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective (2015, Homo sapiens,Mus musculus,Canis lupus familiaris,Candida dubliniensis,Salmonella enterica subsp. enterica serovar Typhimurium,Human gammaherpesvirus 4,Dipturus trachyderma)
• The TREM2-DAP12 signaling pathway in Nasu–Hakola disease: a molecular genetics perspective (2015, Homo sapiens,Mus musculus,Canis lupus familiaris,Candida dubliniensis,Salmonella enterica subsp. enterica serovar Typhimurium,Human gammaherpesvirus 4,Dipturus trachyderma)
• Apoptosis response pathway (2015, Plasmodium falciparum,Homo sapiens)
• Part of the TGFB pathway depicted from KEGG pathways, where we observe similar changes in transcript levels of genes between both types of treatments (K562 EV and the 32-nt synthetic RNA) in both BJ and HUVEC cells (2015, synthetic RNA,Homo sapiens)
• Model illustrating the role of Ca2+/calmodulin (CaM) in regulation of heat shock response and H2O2 homeostasis in plants (2015, Arabidopsis thaliana,Homo sapiens)
• Biochemical network modeled in this study (2015, NA)
• Key Figure: Developmental and Disease-associated Pathways Regulated by Chromodomain Helicase DNA Binding Protein 7 (CHD7).CHD7 can affect the activity of several signalling pathways that control development (2015, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Metabolic pathways of Lactobacillus fermentum 222 and Lactobacillus plantarum 80 (2015, NA)
• Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Corvus corax,Erebia meta)
• Signaling pathway analysis of the potential mature EBOV miRNA target genes (2015, Human immunodeficiency virus 1,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,West Nile virus,Ebola virus,Dengue virus type 2,Merkel cell polyomavirus,Hepatovirus A,Zaire ebolavirus,Macacine alphaherpesvirus 1,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,NA,NA)
• Major pathways of apoptosis (2015, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Cyprinus carpio)
• Label-free Quantitative Analysis of Changes in Broiler Liver Proteins under Heat Stress using SWATH-MS Technology (2015, Gallus gallus,Anas platyrhynchos,Cairina moschata,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Sus scrofa,Streptococcus pyogenes,Mytilus edulis,mixed sample)
• Myogenesis through the IGF/AKT/mTOR pathway (2015, Mus musculus,Rattus norvegicus,Capra hircus,Equus caballus,Homo sapiens)
• Binding proteins (2015, Mus musculus,Homo sapiens)
• Manipulation of neutrophil function by P (2015, NA)
• Coronin-1C-mediated Rac1 trafficking (2015, NA)
• CLN3 and sphingolipid signaling pathway interactions analyzed using Pathway Studio (2015, Bos taurus,Equus caballus,Homo sapiens,Mus musculus)
• RNAi pathways in insects (2015, NA)
• Epithelial cell recognition and discrimination of Candida albicans yeast and hyphae (2015, NA)
• IGFR1, a possible target in tumor progression and metastasis (2015, NA)
• Recently Identified Functions for N-Terminal (Nt) Acetylation in Plants (2015, NA)
• SGK1-mediated signaling pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Insulin-mediated Akt signaling (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• S-nitrosylation in TNF-JNK-AP-1 signaling (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• S-nitrosylation in classical TNF-NF-kB signaling (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• S-nitrosylation in TRAIL/DR4 and FaL/Fas signaling pathways (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Sonic Hedgehog in SCLC (2015, Homo sapiens)
• Schematic overview of estradiol-mediated genomic signaling pathway via nuclear ERA and rapid nongenomic signaling pathways via GPER and membrane isoform of ERA (2015, NA)
• Schematic overview of the multiple signaling pathways to apoptosis, necroptosis and autophagy (2015, Homo sapiens,Mus musculus,Vaccinia virus)
• Interactomic analysis by ingenuity pathway analysis (IPA) of significant molecules (2015, Geodia cydonium,Homo sapiens)
• Pathway Express analysis of the host response to IBV infection in the trachea of susceptible birds (Line 15I) (2015, NA)
• PLB regulates death receptor signaling in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis (2015, Homo sapiens)
• PLB regulates cell cycle at G2/M checkpoint in SCC25 cells.Notes: SCC25 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis (2015, Homo sapiens)
• Schematic diagram shows that PLB regulates the Nrf2-mediated oxidative signaling pathway and its downstream proteins NQO1, GST, and HSP90 in SCC25 cells.Abbreviations: ROS, reactive oxygen species; GST, glutathione S-transferase (2015, Homo sapiens)
• Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells (2015, Homo sapiens)
• Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-Beta-catenin signaling axis in a microRNA-34a dependent manner (2015, NA)
• Schematic model of MIF pathways in breast cancer cells (BCC) (2015, NA)
• Two separate GA13 Switch Region signaling pathways (2015, Homo sapiens,Mus musculus)
• 20E up-regulates Hippo to induce PCD (2015, NA)
• Data analysis of the identified Snf1 interactors (2015, NA)
• Cd-elevated genes associated with mitochondrial oxidative phosphorylation pathway that occurs in electron transport system (2015, NA)
• Signaling pathways required for encephalomyocarditis virus (EMCV) to stimulate pro-inflammatory gene expression in macrophages (2015, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Encephalomyocarditis virus,Coxsackievirus B4,Kilham rat virus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Cerobasis alpha)
• DNA damage response activates cell cycle checkpoint (2015, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Xenopus laevis)
• Evolutionary conservation of chromatin remodeling in inflammatory gene expression (2015, NA)
• TLR Signaling and NFKB activation (2015, NA)
• Nuclear receptors can alter NFKB signaling and activity (2015, Homo sapiens,Mus musculus,Escherichia coli)
• Diagrammatic representation of mammalian target of rapamycin pathway: A crucial intersection of type 2 diabetes and Alzheimer’s disease (2015, NA)
• Diagrammatic representation of molecular orchestra downstream of insulin receptor (2015, NA)
• JAK-STAT signaling pathway and its interaction with viral proteins (2015, NA)
• effect of lipoxins on cytoplasmic signaling cascades and transcription factors.Notes: Lipoxin binds to its G protein-coupled receptor ALX/Formyl peptidyl receptor triggering a wide array of cytoplasmic signaling cascades (2015, Human gammaherpesvirus 4,unidentified influenza virus,Respiratory syncytial virus,Human gammaherpesvirus 8,H5N1 subtype,Mus musculus,Rattus norvegicus,Platycladus orientalis,Salix alba,Homo sapiens,NA)
• Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype (2015, Bos taurus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Helicobacter pylori,Human papillomavirus type 16,Triportheus paranensis,Psidium guajava)
• Tumor Necrosis Factor Alpha and Insulin-Like Growth Factor 1 Induced Modifications of the Gene Expression Kinetics of Differentiating Skeletal Muscle Cells (2015, Mus musculus,Homo sapiens)
• Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets (2015, Homo sapiens,Mus musculus)
• Regulated protein networks in GM-BMMs versus M-BMMs (2015, NA)
• Quantification of the full chemotaxis pathway (2015, Mus musculus,Homo sapiens)
• mtROS in bacterially triggered immune responses (2015, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Listeria monocytogenes,Streptococcus pneumoniae,Bacillus anthracis,Campylobacter jejuni,Streptococcus suis,Homo sapiens,Mus musculus,Vesicular stomatitis virus,Schistosoma mansoni)
• Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNG Regulation (2015, Homo sapiens,Mus musculus,Triticum aestivum,Pekania pennanti)
• Schematic showing hypothesised regulation of MT-2A gene expression by zinc.(1) Increased extracellular zinc is transported into the cell by the cellular zinc importer, ZIP1 (2015, Homo sapiens)
• HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling (2015, NA)
• LOX pathway (2015, NA)
• Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4Beta-S-aromatic heterocyclic podophyllum derivatives display antitumor activity (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Talaromyces purpureogenus)
• Regulation of the Golgi via the GOLPH3 pathway (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Connecting Myokines and Metabolism (2015, NA)
• Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice (2015, NA)
• Pathogen-induced signal transduction pathways (2015, Puccinia triticina,Homo sapiens)
• MET is required for the recruitment of anti-tumoural neutrophils (2015, Mus musculus,Rattus norvegicus,Armoracia rusticana,Solanum lycopersicum,Cricetus cricetus,Campanula medium,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mouse mammary tumor virus)
• Novel mechanisms Shp-2 used to regulate the IFN-Alpha-induced Jak/Stat1 signalling pathway (2015, NA)
• Hypothetical Model for the Transduction of Synaptic Stimuli to Long-Term Plasticity (2015, NA)
• Schematic diagram for the signaling pathway involved in dexamethasone-induced TRPC4 channel activity (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Diaporthe sclerotioides)
• Characteristics, regulators and effects of the epithelial-mesenchymal transition (EMT) (2015, NA)
• The proposed mechanism for the NSAID-induced reduction in vasa recta diameter (2015, Rattus norvegicus,Homo sapiens)
• Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway (2015, NA)
• The primary epidermal growth factor receptor (EGFR) signaling pathway (2015, NA)
• Stem cell-derived exosomes: roles in stromal remodeling, tumor progression, and cancer immunotherapy (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Equus caballus)
• Canonical Wnt3a pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Involvement of Crk adaptor proteins in TCR- and integrin-coupled signaling pathways that regulate T-lymphocyte adhesion (2015, NA)
• Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway (2015, Homo sapiens,Mus musculus,Bos taurus)
• Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan (2015, NA)
• TNF-induced programmed cell death pathways (2015, NA)
• Small Molecule DAM Inhibitor, Pyrimidinedione, Disrupts Streptococcus pneumoniae Biofilm Growth In Vitro (2015, Streptococcus pneumoniae,Homo sapiens)
• Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula (2015, NA)
• Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula (2015, NA)
• Therapeutic targeting of the canonical WNT pathway (2015, NA)
• ErbB3 in RAF-inhibited mutant BRAF melanoma cells (2015, NA)
• TCR-mediated integrin activation inside-out signaling (2015, NA)
• Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle (2015, Bos taurus,Sus scrofa,Zea mays,Candida dubliniensis,Ovis aries,Iris germanica,Caenorhabditis elegans,Coturnix coturnix,Caenorhabditis briggsae,Actitis hypoleucos,Homo sapiens,Mus musculus)
• Genes involved in Parkinson disease and in the autophagy-lysosome pathway (2015, NA)
• Regulation of autophagy by the MTORC1 signaling pathway in cancer cells (2015, NA)
• Neuroimmune signaling integrates central nervous system (CNS) responses to alcohol and stress (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Bison bison)
• Alcohol’s effects on fibrogenic pathways in hepatic stellate cells (HSCs) (2015, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome)
• Alcohol’s effects on pro-inflammatory pathways in liver macrophages (i.e., Kupffer cells) (2015, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome)
• Functional architecture of AXAN (2015, Homo sapiens)
• PirB-mediated growth cone collapse and axon growth inhibition.A classical axon inhibition signaling pathway: Nogo on the oligodendrocyte surface binds to the NgR-LINGO1-P75 receptor complex on the neuronal membrane (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulatory relationships of a KEGG gene set for the human T cell receptor signaling pathway in RegNetwork (2015, Mus musculus,Rattus norvegicus,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Escherichia coli IS1,Homo sapiens,Saccharomyces cerevisiae,Influenza A virus)
• Mitochondrial signaling in cell-to-cell interactions at hypoxia (2015, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens)
• Canonical Wnt pathway illustrating the roles of PITX2 dependant genes (2015, Homo sapiens,Mus musculus,Bos taurus)
• Bioinformatics Analyses of the Role of Vascular Endothelial Growth Factor in Patients with Non-Small Cell Lung Cancer (2015, Homo sapiens,Mus musculus)
• Hemorrhage Exacerbates Radiation Effects on Survival, Leukocytopenia, Thrombopenia, Erythropenia, Bone Marrow Cell Depletion and Hematopoiesis, and Inflammation-Associated microRNAs Expression in Kidney (2015, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Equus kiang,Homo sapiens,Dengue virus,Sequoia sempervirens)
• TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System (2015, Homo sapiens,Mus musculus)
• IL-33/ST2 signaling pathway in mast cells (2015, Alternaria alternata,Ambrosia artemisiifolia,Homo sapiens,Mus musculus,unidentified influenza virus)
• Functions of FGF19 and the corresponding mechanisms (2015, NA)
• Involvement of the cholinergic system in gintonin-mediated anti-Alzheimer’s disease (AD) through LPA receptor activation (2015, Armoracia rusticana,herbal medicine,Panax ginseng,Ginkgo biloba,Mus musculus,Rattus norvegicus,Homo sapiens,Merluccius merluccius)
• In vivo mechanistic action of E4orf1 in the white adipocyte (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human adenovirus 36)
• EGL-18 mediates seam cell fate specification in the embryo and larva downstream of different inputs (2015, Caenorhabditis elegans,Homo sapiens)
• Wnt signaling regulates the asymmetry of the larval seam cell divisions (2015, Homo sapiens,Caenorhabditis elegans)
• The PI3K/mTOR signalling pathway with pharmacological agents in pre-clinical/clinical development for CLL indicated (2015, Homo sapiens,Mus musculus)
• Fish nucleic acid PRR signaling pathways (2015, Gallus gallus,Danio rerio,Oncorhynchus mykiss,teleost fish,Cyprinus carpio,Carassius auratus,Salmo salar,Dipnomorpha,Salmo trutta,Oreochromis niloticus,Ctenopharyngodon idella,Paralichthys olivaceus,Ictalurus punctatus,Dicentrarchus labrax,Epinephelus coioides,catfish,Gadus morhua,Takifugu rubripes,Sparus aurata,Larimichthys crocea,Scophthalmus maximus,Carassius carassius,Labeo rohita,Melanogrammus aeglefinus,Pimephales promelas,Oplegnathus fasciatus,Abramis brama,Cirrhinus mrigala,Channa argus,Esox lucius,Rachycentron canadum,Larimichthys polyactis,Etroplus suratensis,Conger myriaster,Latris lineata,unidentified influenza virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Human alphaherpesvirus 2,Encephalomyocarditis virus,Reovirus sp.,Grass carp reovirus,Infectious pancreatic necrosis virus,Sprivivirus cyprinus,Viral hemorrhagic septicemia virus,Striped jack nervous necrosis virus,Cyprinid herpesvirus 3,Rock bream iridovirus,Snakehead virus,Grass carp hemorrhagic virus,Listeria monocytogenes,Chlamydia muridarum,Aeromonas salmonicida,Homo sapiens,Mus musculus,Iris germanica)
• PI3Ks signaling during G2/M progression and mitosis phase (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Regulation of oocyte maturation (2015, NA)
• NF KB signalling pathway (2015, NA)
• MK-2206 resistance in Akt transduction (2015, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Network associated with the proteins in (2015, Homo sapiens)
• Germinal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex (2015, NA)
• CTLA-4 and PD-1 pathways (2015, NA)
• Components of the PI3K/AKT pathway (PI3K, Akt and mTOR) targeted by small molecule inhibitors (2015, NA)
• Components of the MAP kinase pathway targeted by small molecule inhibitors (2015, NA)
• Many signals overlap with PI3K/AKT/mTOR pathways in tumor-specific CD8+ T cells (2015, Sequoia sempervirens,Streptococcus pyogenes,Serratia marcescens,Galatella linosyris,Homo sapiens,Mus musculus,NA)
• JAK/STAT signaling directly relays extracellular signals to transcription in T cells (2015, Sequoia sempervirens,Streptococcus pyogenes,Serratia marcescens,Galatella linosyris,Homo sapiens,Mus musculus,NA)
• TAA-specific CD8+ T cells often lack co-stimulation for an immune response against tumors (2015, Sequoia sempervirens,Streptococcus pyogenes,Serratia marcescens,Galatella linosyris,Homo sapiens,Mus musculus,NA)
• TGF-Beta-IDO-SHP axis (2015, Escherichia coli,Bacillus anthracis,Escherichia coli IS1,Haemophilus ducreyi,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Saccharomyces cerevisiae,Bombyx mori,NA)
• Combination of transcriptomic and metabolomic analyses reveals a JAZ repressor in the jasmonate signaling pathway of Salvia miltiorrhiza (2015, Salvia miltiorrhiza)
• ‘Obesity’ is healthy for cetaceans? Evidence from pervasive positive selection in genes related to triacylglycerol metabolism (2015, NA)
• Summary of the regulatory pathway of ALR tubule scission (2015, NA)
• Schematic model of WNT signaling by the FZD receptor(s) (2015, NA)
• Opposing effects of anthrolysin, LF and EF on host cell apoptosis (2015, Bacillus anthracis,Lactobacillus acidophilus,Bacillus anthracis str. Sterne,Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Macaca mulatta)
• Reactive oxygen species (ROS) regulation of mitogen activated protein kinases (MAPK) signaling pathway in biotic and abiotc stresses (2015, NA)
• Anti-apoptotic effects of astaxanthin in neurological diseases (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Cricetus cricetus,Haematococcus lacustris,Phaffia rhodozyma,Homo sapiens,Helicobacter pylori)
• Anti-oxidative effects of astaxanthin in neurological diseases (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Cricetus cricetus,Haematococcus lacustris,Phaffia rhodozyma,Homo sapiens,Helicobacter pylori)
• Mechanism for the modulating effect of C22:6n-3 and uric acid on glucose metabolism (2015, NA)
• Hedgehog Signaling in Malignant Pleural Mesothelioma (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Paraechinus aethiopicus)
• Endocytic and secretory pathways (2015, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Enterovirus C,Lyssavirus rabies,Human betaherpesvirus 6,Merkel cell polyomavirus,Hepatovirus A,human papillomavirus 11,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Bacillus anthracis,Clostridium perfringens,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,NA,NA,NA)
• Selected signal networks induced by Dectin-1 and Dectin-2 (2015, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Nakaseomyces glabratus,Carex albicans var. albicans,Homo sapiens,Mus musculus,gut metagenome,Schistosoma mansoni,Aphyosemion alpha)
• MiR-146 a/b effect on induction of endotoxin tolerance (2015, Homo sapiens,Mus musculus,Bos taurus,Escherichia coli)
• The differentially expressed profiles (2015, NA)
• Cell biology functions and pathways of the genes involved in melanoma susceptibility (2015, NA)
• Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma (2015, Homo sapiens,Bos taurus)
• Summary of mapped candidate genes involved in the biosynthesis of storage lipids in J (2015, Jatropha curcas)
• Schematics of cAMP/PKA regulation of polycystin-2 (2015, NA)
• Schematic illustrating the immune pathway of the contact sensitivity (CS) response with afferent and efferent nerves projecting to and from the brain (2015, Rattus norvegicus,Homo sapiens)
• Model describing the modulation of MLP quality control at the proteasome by BAG6 and SGTA (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Gallus gallus,Escherichia coli BL21,NA)
• Defects in ribosomal biogenesis activate p53 and other stress-response mechanisms (2015, Vesicular stomatitis virus,Subgroup C,Feline leukemia virus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Danio rerio)
• Signaling pathways in hepatocyte polarity (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris,Hepatitis B virus,NA)
• The Pigment in Alkaptonuria Relationship to Melanin and Other Coloured Substances: A Review of Metabolism, Composition and Chemical Analysis (2015, NA)
• Diagram summarizing the Rheb-mTOR signaling pathway and findings presented in this study (2015, Mus musculus,Homo sapiens)
• Biological mechanisms of MALAT1 in CRC (2015, NA)
• Signal pathways of chondrocyte hypertrophy (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Mouse mammary tumor virus,Adeno-associated virus,Homo sapiens,Gallus gallus)
• UPRmt models in mammalians (2015, NA)
• Proposed model of role of RNase L in crosstalk between autophagy and apoptosis (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Influenza A virus,Human alphaherpesvirus 1,Chikungunya virus,Armoracia rusticana,Matthiola incana,Homo sapiens,Mus musculus,vectors,NA)
• Regulation of cell metabolism by proto-oncogenes and tumour suppressors (2015, NA)
• Regulation of autophagy by amino acids (2015, NA)
• Autophagic machinery (2015, NA)
• Schematic diagram showing select signaling pathways in melanoma (2015, NA)
• Genome Sequence and Transcriptome Analyses of Chrysochromulina tobin: Metabolic Tools for Enhanced Algal Fitness in the Prominent Order Prymnesiales (Haptophyceae) (2015, NA)
• How the embryo makes a limb: determination, polarity and identity (2015, NA)
• Core UPR pathway and its modulation on autophagy (2015, NA)
• Molecular events in autophagy pathway (2015, NA)
• Metabolic Characteristics of a Glucose-Utilizing Shewanella oneidensis Strain Grown under Electrode-Respiring Conditions (2015, Shewanella oneidensis,Homo sapiens)
• miRNAs that control signaling governing osteogenesis and adipogenesis (2015, NA)
• Metformin action in the hepatocyte and cancer cells (2015, Homo sapiens)
• Signaling pathway diagram of ApoJ action in NRVCs (2015, NA)
• Suggested mechanism of action by WISP-2 in gastric cancer cells (2015, NA)
• A neurotrophin axis in the biology of DLBCL cells (2015, NA)
• Signaling network of genes that are strongly upregulated following MARV challenge of NHPs (2015, Homo sapiens,Macaca mulatta)
• Ethylene signaling pathway (2015, NA)
• Up-regulation of the inflammatory response biofunction in Rwandan adults during mild malaria compared with day 30 of convalescence (2015, NA)
• Harnessing the apoptotic programs in cancer stem-like cells (2015, Homo sapiens)
• Processing of the Notch signaling pathway and the nuclear cycle (2015, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• YAP may be maintained in inactivated state by VE-cadherin-PI3/Akt signaling axis in quiescent endothelial cells (2015, Mus musculus,Homo sapiens)
• Hypothalamic PKA regulates leptin sensitivity and adiposity (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus)
• Redox control of protein degradation (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Xenopus laevis,prion)
• Participation of HPV oncogenes at different levels of Wnt/Beta-catenin cell signaling regulation (2015, Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Human papillomavirus types,human papillomavirus 18,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis)
• Wnt/Beta-catenin cell signaling pathway (2015, Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Human papillomavirus types,human papillomavirus 18,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis)
• Negative regulators take action at almost all steps of TLR signaling (2015, Arabidopsis thaliana,Paracoccus denitrificans)
• DEK-mediated regulation of NFKB pathway activity in a dose-dependent manner (2015, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,Human papillomavirus,Human gammaherpesvirus 8,Human immunodeficiency virus 2,Nicotiana tabacum,Lareunionomyces loeiensis,Panax ginseng,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,NA)
• Intracellular pathway of insulin signaling and proposed impairment by DAG (2015, Mus musculus,Homo sapiens)
• Cortical actin regulation modulates vascular contractility and compliance in veins (2015, Mustela putorius furo,Homo sapiens)
• Effects of exercise on the signalling pathways associated with muscle growth and wasting in sarcopenia and cachexia (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Schematic diagram showing the hypothetical effects of CME on the PI3K-Akt-mTOR/signaling pathway and apoptosis in CNE-1 cells (2015, NA)
• Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer’s Disease (2015, Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus,prion)
• Meta-Analysis of Microarray Data of Rainbow Trout Fry Gonad Differentiation Modulated by Ethynylestradiol (2015, NA)
• Signal transduction pathways and the oxidative stress response (2015, Homo sapiens,Saccharomyces cerevisiae)
• An example of pathway simulation model (2015, NA)
• Downstream analysis of Wnt-related gene expression from aged animals predicts a decrease in cell viability and transcription of RNA (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• FANCM and partner proteins in coping with template lesions during DNA replication (2015, NA)
• Proposed model of HDAC10 regulation in G2/M transition (2015, Mus musculus,Homo sapiens)
• Some of the proposed signaling pathways activated by NK-R (2015, NA)
• Regulation of autophagy.Notes: mTOR is one of the most important regulators of autophagy (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,clinical samples)
• Many anticancer agents mediate tumour cell killing though activation of the BCL-2-regulated apoptotic pathway (2015, NA)
• Simplistic illustration of the Wnt/Beta-catenin cellular signalling pathway in an osteoblast (2015, NA)
• Effect of purple corn anthocyanins (PCA) on CCN2 expression (2015, NA)
• Pathways to AT2 cell injury/dysfunction defined by using mutant proSP-C isoforms as prototype substrates (2015, NA)
• Network integrating gene–metabolite associations and metabolite–metabolite correlations (2015, NA)
• TRAF6 regulation by arginine methylation (2015, NA)
• Proposed model of mitochondrial XIAP action in relation to the canonical MOMP pathway (2015, NA)
• Impact of HER2-mediated inhibition of MLK3 kinase activity on breast cancer cell death and tumorigenesis (survival) (2015, Homo sapiens)
• Working model of convergent pLTF pathways (2015, Rattus norvegicus,Homo sapiens)
• Linking the actin-folding capacity to MRTF-A/SRF signaling (2015, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Saccharomyces cerevisiae)
• ERRs are key transcriptional factors that regulate cellular energy metabolism (2015, NA)
• Productive pathway of 2HB from AKB in the sulfur-containing amino acid metabolic pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• Redox control of the cellular energy metabolism (2015, NA)
• Ingenuity pathway analysis showing up (green) and down-regulation (red) of miRNAs involved in papillary thyroid cancer (PTC) tumor samples when compared to normal samples (2015, Homo sapiens,Rattus norvegicus,Sequoia sempervirens)
• Dynamic differentially expressed (DE) genes were involved in T and B cell development as well as innate and adaptive immune response (2015, NA)
• Metabolic pathways with compounds that can be used as molecular imaging probes for HP MRI (2015, NA)
• Metabolic pathway of pyruvate to ethanol in T (2015, NA)
• Schematic view of the integration of Sema3-Nrp with the Hh signal pathway by controlling PKA and PDE4 (2015, NA)
• Schematic depiction of hCG/cAMP signaling pathway in trophoblasts (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus 1)
• Microbial subversion of neutrophil function leads to periodontal inflammation (2015, NA)
• Non-invasive prognostic protein biomarker signatures associated with colorectal cancer (2015, NA)
• NRP1 up-regulation of radio-resistance in human NSCLC via the VEGFR2-PI3K-NFKB pathway (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Dipturus trachyderma,Corynebacterium phage gamma)
• Proposed model for multiple-target inhibitory action in TT cells (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Anti-tumor mechanism of combi-targeting molecule (2015, Mus musculus,Homo sapiens)
• The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper (2015, NA)
• FSH signaling (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Cavia porcellus,Macaca fascicularis,Macaca radiata)
• The Control of -Regulated Growth by .1 (2015, Arabidopsis thaliana,Tracheophyta)
• Interaction network for human CIBLIN transcriptional regulators (2015, NA)
• Proposed model summarizing the effect of streptolysin S on keratinocyte signaling during Streptococcus pyogenes infection (2015, NA)
• Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling (2015, Homo sapiens,Mus musculus,Bos taurus,Venustaconcha ellipsiformis)
• Mevalonate pathway for cholesterol biosynthesis showing the effects of inhibition of HMG-CoA reductase by statins (2015, Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,H5N1 subtype)
• Surfactant metabolism (2015, NA)
• How to Turn On an Ancient Metabolic Enzyme? Add Insulin and Deacetylate (2015, Homo sapiens)
• 6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death (2015, Armoracia rusticana,herbal medicine,Matthiola incana,Allium sativum,Zingiber officinale,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Case study 1 (synthetic signaling pathway): Hypergraph showing every possible logic gate consistent with the prior knowledge network (2015, NA)
• Glutathione redox cycle (2015, NA)
• Diagram showing the possible mechanism of serotonin mediated signaling pathway activated by BME during learning (2015, Ginkgo biloba,Bacopa monnieri,Tinospora cordifolia,Evolvulus alsinoides,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Salicylic acid and anthocyanidins use different strategies to inhibit tumor cell protective catalase (2015, NA)
• HOCl signaling pathway A (2015, NA)
• Complete Genome Sequence of a High Lipid-Producing Strain of Mucor circinelloides WJ11 and Comparative Genome Analysis with a Low Lipid-Producing Strain CBS 277.49 (2015, NA)
• SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells (2015, NA)
• Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2015, NA)
• Harnessing endogenous stem/progenitor cells for tendon regeneration (2015, NA)
• IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms (2015, NA)
• FASN inhibition blocks metabolic and signal transduction pathways vital to cancer cell growth, proliferation, and survival (2015, NA)
• Pathway enrichment analysis reveals PI3K/PTEN/AKT signalling and apoptosis pathway as the most significantly related pathway (2015, Diaporthe sclerotioides,Bikinia letestui,Homo sapiens,Dipturus trachyderma)
• The acute phase response is not generally up regulated in patients with < 14 mo survival (2015, Homo sapiens)
• Discovery of Intermediary Genes between Pathways Using Sparse Regression (2015, NA)
• Discovery of Intermediary Genes between Pathways Using Sparse Regression (2015, NA)
• Antineoplastic mechanisms of ultrasound (2015, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Adeno-associated virus)
• Sequence of events that leads to progression toward HIV associated Neurocognitive Disorders (HAND) during cocaine abuse, cocaine + HIV infection and HIV infection alone (2015, Human immunodeficiency virus 1,Human immunodeficiency virus,Human immunodeficiency virus 2,Homo sapiens,Rattus norvegicus)
• Proteomic approaches for profiling negative fertility markers in inferior boar spermatozoa (2015, NA)
• Differential transcriptional activation of the Adamts-1 and Cox-2 genes in response to VEGF, Ang-II, TNFA, and IL-1B (2015, NA)
• Translational control by ERK and mTOR (2015, NA)
• Unveiling the metabolic potential of two soil-derived microbial consortia selected on wheat straw (2015, NA)
• Schematic diagram of the protein components involved in the myelin protein-derived inhibition of neurite growth (2015, NA)
• The changes in soleus muscle gene expression within the TGFB and BMP pathways, with SCI (a) and acute response to treadmill training (b) (2015, NA)
• An offshoot of a signalling pathway resulting in the activation of an alternate M1 or M2 response is an important constructive feature of the intracellular pathways of macrophage reprogramming (2015, NA)
• Notch-signalling pathway in macrophage reprogramming and its interaction with the TLR-dependent signalling pathway (2015, NA)
• Yeast MAPK signaling pathways are associated to hypersensitivity to cell wall stress conditions (2015, Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Nakaseomyces glabratus,Saccharomyces cerevisiae BY4741,Homo sapiens)
• Neoglycoconjugate Containing the Human Milk Sugar LNFPIII Drives Anti-Inflammatory Activation of Antigen Presenting Cells in a CD14 Dependent Pathway (2015, NA)
• Multimodality targeting of MM in the context of the BM microenvironment (2015, NA)
• NFKB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Papio anubis,Armoracia rusticana,Entamoeba histolytica)
• Feed-back and feed-forward control of cAMP by the ubiquitin-proteasome system (UPS) (2015, NA)
• Advances in epigenetic therapy (2015, NA)
• Mechanisms through which complement mediates antibody-initiated kidney diseases (2015, NA)
• Complement and adaptive immunity (2015, NA)
• Complement cascade (2015, NA)
• GB protein and the TupA Co-Regulator Bind to Protein Kinase A Tpk2 to Act as Antagonistic Molecular Switches of Fungal Morphological Changes (2015, NA)
• Time-series transcriptome analysis for adaptive evolution of E (2015, Escherichia coli,Escherichia coli K-12,Escherichia coli str. K-12 substr. MG1655,Lactococcus lactis,Synechocystis sp. PCC 6803,Escherichia coli str. K-12 substr. W3110,Escherichia coli IS5,Homo sapiens,Matthiola incana,Cloning vector pUC19)
• MAPK signaling cascade in yeast and plants (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Escherichia coli,Escherichia coli IS1,Homo sapiens)
• OVOL guides the epithelial-hybrid-mesenchymal transition (2015, NA)
• JNK-dependent gene regulatory circuitry governs mesenchymal fate (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases (2015, NA)
• PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases (2015, NA)
• Sperm navigation along helical paths in 3D chemoattractant landscapes (2015, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Arbacia punctulata,Homo sapiens,Escherichia coli,Danio rerio)
• Pharmacologic modulators of the Hippo pathway (2015, NA)
• Schematic models for JAK/STAT cell signaling pathway and the inhibitory actions for JAK/STAT target anticancer drugs (2015, Danio rerio,teleost fish,Salmo salar,Paralichthys olivaceus,Ictalurus punctatus,Larimichthys crocea,Scophthalmus maximus,Oplegnathus fasciatus,Abramis brama,Drosophila melanogaster,Penaeus vannamei,Eriocheir sinensis,Pinctada fucata,Sipunculus nudus,Bugula neritina,Ecteinascidia turbinata,Jorunna funebris,Taxus brevifolia,Penicillium sp.,Gracilaria gracilis,Aeromonas hydrophila,Salinispora tropica,Homo sapiens,Mus musculus,uncultured marine bacterium)
• Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway (2015, NA)
• Key mechanisms regulating vascular smooth muscle tone (2015, Mus musculus,Rattus norvegicus,Danio rerio,Homo sapiens)
• Network representation of microRNA (2015, Rattus norvegicus,Homo sapiens)
• Proposed pathway of cAMP signaling after FID addition during in vitro maturation (2015, Bos taurus,Homo sapiens)
• Transcriptomic analysis of cyclic AMP response in bovine cumulus cells (2015, Bos taurus,Homo sapiens)
• The Ca2+signaling pathways in astrocytes underlying cerebral blood flow (CBF) regulation (2015, NA)
• Activation of Notch signalling pathway: Gamma-secretase and aspartyl protease serve as primary targets for Notch-specific investigational drug design (2015, Homo sapiens)
• Androgen synthesis pathway (2015, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Octanoylation of early intermediates of mycobacterial methylglucose lipopolysaccharides (2015, NA)
• RTK signaling pathways and representative regulatory microRNAs (2015, Homo sapiens,Mus musculus,Caenorhabditis elegans,NA)
• Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli (2015, Escherichia coli,Homo sapiens)
• Illustration of data-enhanced Bayesian network inference (2015, NA)
• Inactivation of DPH5 induces NFKB and death receptor pathways (2015, Homo sapiens,Pseudomonas aeruginosa)
• Intracellular mechanisms involved in the control of FGF21 production and action on the heart (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Treg suppression (2015, NA)
• IPA analysis based hnRNPD networks in oral cancer (2015, Nicotiana tabacum,Diaporthe sclerotioides,Areca catechu,Homo sapiens,Bos taurus,Oryctolagus cuniculus,Mandrillus leucophaeus,Mus musculus,Human papillomavirus type 16)
• Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,NA)
• Evidence of Active Pro-Fibrotic Response in Blood of Patients with Cirrhosis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,NA)
• Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway (2015, NA)
• Paracrine networks acting downstream of epithelial ESR1 in the mouse uterus during implantation (2015, Mus musculus,Homo sapiens)
• Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells (2015, Bos taurus,Equus caballus,Paraechinus aethiopicus,Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Spleen focus-forming virus,Homo sapiens,Sequoia sempervirens)
• Schematic diagram to show SHP/RAS/ERK pathway and Gamma-T3 targets in mammosphere cells (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human papillomavirus,Molva molva)
• Rad4–Rad23 and GG-NER E3 ligase function in DDR signalling and dNTP synthesis (2015, NA)
• Genome sequence-derived metabolic reconstruction of Pyrobaculum yellowstonensis strain WP30 (2015, metagenome)
• Mechanisms that underlie protection of AAV mice against age-related obesity and insulin resistance (2015, Homo sapiens,Mus musculus,Adeno-associated virus)
• Role of the circadian clock in integration of abiotic stress signals (2015, NA)
• Network Topologies Decoding Cervical Cancer (2015, NA)
• Temporal Gene Expression of the Cyanobacterium Arthrospira in Response to Gamma Rays (2015, Escherichia coli,Helicobacter pylori,Bacillus subtilis,Bacillus subtilis At2,Synechocystis sp. PCC 6803,Synechocystis sp.,Deinococcus radiodurans,Arthrospira platensis,Halobacterium salinarum,Desulfovibrio vulgaris,Limnospira maxima,Limnospira indica PCC 8005,Deinococcus radiodurans R1 ATCC 13939 DSM 20539,Arthrospira sp.,Limnospira indica PCC 9438,Deinococcus deserti,Diaporthe sclerotioides,Colletotrichum trifolii,Homo sapiens,Dipturus trachyderma,Venustaconcha ellipsiformis)
• Notch1/Numb/Snail signaling-induced EMT in adenomyosis (2015, NA)
• Simplified overview (a modified schema from ) of some molecular events (and potential drug targets) involved in bacterial autophagy (2015, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Escherichia coli K-12,Vibrio cholerae,Streptococcus pyogenes,Bacillus anthracis,Shigella flexneri,Francisella tularensis,Streptomyces hygroscopicus,Serratia marcescens,Streptococcus sp. group A,Yersinia pestis,Burkholderia pseudomallei,Yersinia pseudotuberculosis,Bordetella pertussis,Helicobacter pylori SS1,Burkholderia pseudomallei THE,Saccharomyces cerevisiae,Cryptococcus neoformans var. grubii,Euphorbia fischeriana,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,prion,H5N1 subtype)
• Simplified overview (a modified schema from [,,] of LC3-associated phagocytosis (LAP) and canonical autophagy (2015, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Escherichia coli K-12,Vibrio cholerae,Streptococcus pyogenes,Bacillus anthracis,Shigella flexneri,Francisella tularensis,Streptomyces hygroscopicus,Serratia marcescens,Streptococcus sp. group A,Yersinia pestis,Burkholderia pseudomallei,Yersinia pseudotuberculosis,Bordetella pertussis,Helicobacter pylori SS1,Burkholderia pseudomallei THE,Saccharomyces cerevisiae,Cryptococcus neoformans var. grubii,Euphorbia fischeriana,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,prion,H5N1 subtype)
• UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFKB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFKBp65 Ser276 Axis (2015, NA)
• Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus (2015, NA)
• Transcriptome Profiling and Molecular Pathway Analysis of Genes in Association with Salinity Adaptation in Nile Tilapia Oreochromis niloticus (2015, NA)
• LGR4-Wnt/Beta-catenin signaling pathway (2015, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Oryza sativa)
• Neuronal apoptosis network (2015, NA)
• Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes (2015, NA)
• Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases (2015, NA)
• Signaling pathways associated with CLRs on dendritic cells (2015, NA)
• Model illustrating the mechanism underlying inhibition of TGFB1–induced EMT and cell migration by KF (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Botrytis virus X)
• Ingenuity pathway analysis comparing gingivitis to healthy subjects (2015, Homo sapiens)
• Network of miRNAs and target genes in OS (2015, NA)
• Pathway in males that leads to growth factor activation of PI3K/AKT of AR and GRB induced growth (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Sapajus apella,Schistosoma haematobium)
• Adaptive stress signaling in targeted therapy resistance in cancer (2015, Homo sapiens,Mus musculus,NA)
• Known regulatory mechanisms of NRF2, highlighting miRNA-mediated influences (2015, NA)
• Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics (2015, Oryctolagus cuniculus,Panthera tigris,Homo sapiens,Mus musculus,unidentified,Sequoia sempervirens)
• PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer (2015, NA)
• Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened (2015, NA)
• Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened (2015, NA)
• Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells (2015, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Candidate Resistant Genes of Sand Pear (Pyrus pyrifolia Nakai) to Alternaria alternata Revealed by Transcriptome Sequencing (2015, NA)
• The insulin/IGF1R signalling pathway (2015, NA)
• Impaired Cell Cycle Regulation in a Natural Equine Model of Asthma (2015, Mus musculus,Rattus norvegicus,Equus caballus,Felis catus,Homo sapiens,Gallus gallus,unidentified,Aspergillus fumigatus)
• 2A-DNT on transcript expression, protein expression and nuclear signaling mapped onto the Kyoto Encyclopedia of Genes and Genomes (KEGG) peroxisome proliferator-activated receptor (PPAR) pathway (2015, NA)
• Signaling pathways involved in CSCs (2015, NA)
• MicroRNA-124 Targets Tip110 Expression and Regulates Hematopoiesis (2015, Homo sapiens,Mus musculus)
• Proposed schematic showing targets of EBN action in the insulin signaling pathway (2015, Mus musculus,Rattus norvegicus,Oryza sativa,Syzygium aromaticum,Homo sapiens,Gallus gallus)
• Gylcogen metabolism in astrocytes (2015, Oryctolagus cuniculus,Equus caballus,Eptesicus fuscus,Mus musculus,Rattus norvegicus,Danio rerio,Rutilus frisii,Homo sapiens,Drosophila melanogaster,prion)
• Proposed signaling pathway involved in VEGF165 and flow/shear stress-induced dilations of retinal arterioles (2015, Sus scrofa,Homo sapiens)
• Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway (2015, Homo sapiens,Human gammaherpesvirus 4,Eucalyptus intertexta)
• Signaling and biochemical pathways activated by T3 and/or T2 in skeletal muscle that promote variations in substrate metabolism, lipid handling, and thermogenesis at the mitochondrial level (2015, NA)
• Transcriptional gene regulatory network in VBL-treated KB-3 cell (2015, NA)
• Major EDCF-mediated signalling pathways in hypertension and diabetes (2015, NA)
• Canonical Wnt pathway (2015, Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis,NA)
• HGF/MET signaling pathway (2015, NA)
• Sub-network of genes regulated by E2F3, E2F4, and the E2F functional group (2015, Human papillomavirus,Human papillomavirus type 16,Homo sapiens)
• Activated signaling pathways that regulate KSHV lytic replication during primary infection (2015, NA)
• Signaling networks activated during primary KSHV infection as analyzed by Kinex antibody array and IPA (2015, NA)
• Biosynthetic pathway of MIA in C (2015, Catharanthus roseus)
• LH/hCG-induced miR-122-mediated LHR mRNA down-regulation (2015, Homo sapiens,Rattus norvegicus)
• SKN-1 regulation in the GSC longevity pathway (2015, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Escherichia coli,Gallus gallus,Olea europaea)
• RAS/RAF/MEK/ERK signal transduction pathway (2015, NA)
• Topologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case (2015, Homo sapiens,Saccharomyces cerevisiae,vectors,Aepyceros melampus,Dendroacalles sigma)
• Retinal growth cone collapse by lysophosphatidic acid (2015, NA)
• HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation (2015, NA)
• Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma (2015, NA)
• Cluster-guided pathway analysis of the response map (2015, NA)
• Inferred network models capture oncogenic signaling pathways in melanoma (2015, NA)
• Proposed model for the complex cross talk between various receptors and mediators in early phase response in allergic rhinitis (2015, NA)
• Synthetic cell fate regulation with engineered yeast MAPK signalling (2015, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Debaryomyces hansenii,Saccharomyces cerevisiae Sigma1278b,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Escherichia coli,Aedes aegypti)
• Representation of the adherens junction pathway map from KEGG (2015, Bos taurus,Sus scrofa,Equus caballus,Homo sapiens)
• Schematic of TRIM21 antiviral mechanism (2015, Mus musculus,Homo sapiens)
• BAFF-induced activation of NFKB signaling and increased expression of proinflammatory cytokines as procachectic mediators (2015, NA)
• Lesser-Known Molecules in Ovarian Carcinogenesis (2015, NA)
• The mechanism by which DHA may interfere with the molecular signalling by activating glycolytic phenotype (2015, NA)
• Nitric oxide signaling pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Insights into the molecular mechanisms of methylmalonic acidemia using microarray technology (2015, NA)
• Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway (2015, NA)
• Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1A pathway in chondrocytes (2015, Mus musculus,Rattus norvegicus,Armoracia rusticana,Candida dubliniensis,Homo sapiens)
• Integrative Analysis of MicroRNA and mRNA Data Reveals an Orchestrated Function of MicroRNAs in Skeletal Myocyte Differentiation in Response to TNFA or IGF1 (2015, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Drosophila melanogaster,Schizosaccharomyces pombe)
• Multiple Protein Kinases via Activation of Transcription Factors NFKB, AP-1 and C/EBPD Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes (2015, NA)
• Using DeDaL for visualizing Fanconi pathway in breast cancer (2015, NA)
• Profiles of central and oxidative stress response metabolism pathways of K (2015, NA)
• PI3K/AKT and HSP90 interacted with ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA (2015, NA)
• NFKB signaling pathway was regulated via ERK1/2 when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA (2015, NA)
• ERK/MAPK signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and pathways were analyzed using IPA (2015, NA)
• EIF2 signaling pathway was regulated when THP-1-derived macrophages were treated with the novel NP-siRNA liposomes at 12.5 μg/mL for 24 hours.Notes: The proteomic response was determined by SILAC, and the pathways were analyzed using IPA (2015, NA)
• Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis (2015, Mycobacterium tuberculosis,Homo sapiens)
• Distinct PI3K isoenzymes control specific cardiovascular processes (2015, Homo sapiens,Mus musculus)
• Selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression (2015, NA)
• Identifying miRNA/mRNA negative regulation pairs in colorectal cancer (2015, NA)
• Identifying miRNA/mRNA negative regulation pairs in colorectal cancer (2015, NA)
• GSH biosynthetic route and GSH cycle (2015, NA)
• Distilling a Visual Network of Retinitis Pigmentosa Gene-Protein Interactions to Uncover New Disease Candidates (2015, Homo sapiens)
• Analyses of interactions among SHRSP-specific genes (2015, NA)
• Analyses of interactions among SHR-specific genes (2015, NA)
• Expression profile of P (2015, Arabidopsis thaliana,Oryza sativa,Solanum lycopersicum,Embryophyta,PX clade,Malus domestica,Brassica napus,Magnoliopsida,Fragaria x ananassa,Pisum sativum,eudicotyledons,Musa acuminata,Ipomoea batatas,Citrus x paradisi,Mangifera indica,Actinidia deliciosa,Lotus japonicus,Ananas comosus,Persea americana,Fragaria vesca,Citrus unshiu,Myrrhis odorata,Amborella trichopoda,Sambucus nigra,Phytophthora cinnamomi,Silene vulgaris,Magnoliidae,Persea americana var. drymifolia,Cyberlindnera americana,Persea nubigena var. guatemalensis,Meloidogyne incognita,Triatoma brasiliensis,Phymata americana americana,Homo sapiens)
• ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis (2015, Homo sapiens)
• ESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis (2015, Homo sapiens)
• iNKT cell activation pathways in sepsis (2015, NA)
• Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling (2015, NA)
• miRNA–gene–pathway regulatory networks (2015, NA)
• Action of MFX and CFX induced S-phase arrest and apoptosis (2015, NA)
• Metabolism of NAD in Plants.The steps involved in the de novo pathway are indicated by blue arrows, the four-step salvage pathway (start from ) is indicated by a black arrow, and two-step salvage pathway is indicated by green arrows (2015, NA)
• Schematic demonstration of PHB-mediated survival or apoptosis responses in multiple cellular compartments of different cell types and molecular mechanism involved (2015, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Saccharomyces cerevisiae,NA)
• miRNAs control inflammatory response in ECs (2015, Homo sapiens,Mus musculus)
• Selective delivery of ITCs to bladder on oral consumption and modulation of cellular targets by ITCs in BC cells and tissues (2015, Armoracia rusticana,Brassica napus,Brassica oleracea,Brassica rapa subsp. pekinensis,Nasturtium officinale,Brassica oleracea var. italica,Brassica napus var. napus,Mus musculus,Rattus norvegicus,Homo sapiens,Mycobacterium tuberculosis variant bovis BCG)
• Dysregulation of the Transforming Growth Factor B Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans,Sequoia sempervirens,NA)
• MicroRNA and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Overview of cholangiocyte role in biliary functions (2015, Human papillomavirus,Reovirus sp.,Simian rotavirus A strain RRV,Mus musculus,Rattus norvegicus,Homo sapiens)
• Polymorphisms in MicroRNA Genes And Genes Involving in NMDAR Signaling and Schizophrenia: A Case-Control Study in Chinese Han Population (2015, Homo sapiens,Mus musculus,Bos taurus,Human alphaherpesvirus 2)
• “aggressive pathway.” Up-regulated genes (red) and downregulated genes (blue) are interconnected in a pathway involved in cell cycle control (2015, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Proposed schematic showing targets of edible bird's nest (EBN) action in the insulin signaling pathway (2015, NA)
• GDF-15 regulates signaling pathways essential for cardioprotection (2015, NA)
• Functional connections brought by the active clusters between T2D and obesity (2015, NA)
• ROS-dependent cellular senescence pathways in MSCs (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• An illustration representing microRNAs (miRNAs) and their targets involved in EGFR signaling pathway in lung cancer and anti-EGFR therapy (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Genes within the BDNF signaling pathway [adapted with permission from Macmillan Publishers Ltd (2015, NA)
• ΔNp63 and TAp63 TF networks (2015, Homo sapiens,Mus musculus,Bos taurus)
• Caspase 3/7‐PKCD‐Akt/p38 MAPK signaling pathway in the radiation‐induced apoptotic cells stimulated live tumor cell growth in human pancreatic carcinoma (Panc1) in vitro (2015, Homo sapiens,Rattus norvegicus,Bos taurus,Dipturus trachyderma)
• Conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Armoracia rusticana,Nicotiana tabacum,Cryptococcus neoformans,Saccharomyces cerevisiae BY4741,Cryptococcus neoformans var. grubii,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Capra hircus,Yersinia pestis,Escherichia coli str. K-12 substr. DH10B,Mus musculus,Rattus norvegicus,Homo sapiens,unidentified shuttle vector)
• Mechanisms involved in autophagy and fibrosis (2015, Homo sapiens)
• Hypothetical model (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic illustrating the proposed mechanism of neuroprotective role of TAK1 inhibition by OZ (2015, NA)
• Proposed GPR40 and PPARG integrated signal transduction pathway in human endothelial cells (2015, Homo sapiens)
• Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Neurospora crassa,Aplysia californica)
• Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation (2015, NA)
• Activation and downstream signaling of class III RTKs (2015, Homo sapiens,Rattus norvegicus,Escherichia coli,Corynebacterium phage gamma)
• Location and signaling pathways of pattern recognition receptors (2015, NA)
• Pim signaling in MM (2015, Moloney murine leukemia virus,Murine leukemia virus,Homo sapiens,Mus musculus)
• Retinoid refractoriness due to phosphorylation of retinoid X receptor A and its restoration by acyclic retinoid in hepatocellular carcinoma (HCC) cells [modified from reference ()] (2015, Homo sapiens)
• Schematic representation of the redox signaling pathways that are postulated to lead to adaptive activation of transcription factors and upregulation of the expression of cytoprotective proteins following contractile activity in skeletal muscle (2015, NA)
• Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus caballus,Mustela putorius furo,Mus musculus,Rattus norvegicus,Escherichia coli,Cavia porcellus,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Armoracia rusticana,Oryza sativa,Homo sapiens,Human parvovirus B19)
• Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model (2015, NA)
• The type I diabetes mellitus pathway in which HLA-A, HLA-B, HLA-C, HLA-DPB1 and GAD1 are involved (2015, Homo sapiens)
• The systemic lupus erythematosus pathway in which HLA-DPB1, HIST1H4J, HIST1H2BO, H3F3C, H2AFY, H3F3A, HIST2H3D, HIST1H4D, HIST2H4B, HIST1H2BL and HIST1H4K are involved (2015, Homo sapiens)
• Proposed anticancer effects of statins (HMG-CoA reductase inhibitors) involving the mevalonate pathway (2015, NA)
• Diagrammatic sketch shows the hypothetical mechanism of HOTAIR in digestive tract cancers (2015, NA)
• Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish (2015, Oncorhynchus mykiss,Oryzias latipes,Carassius auratus,Oreochromis niloticus,Ictalurus punctatus,Takifugu rubripes,Cynoglossus semilaevis,Tachysurus fulvidraco,Micropogonias undulatus,Oryzias luzonensis,Horabagrus nigricollaris,Oryzias dancena,Homo sapiens,Mus musculus,Panthera tigris)
• Comparative Transcriptome Analysis of Differentially Expressed Genes and Signaling Pathways between XY and YY Testis in Yellow Catfish (2015, Oncorhynchus mykiss,Oryzias latipes,Carassius auratus,Oreochromis niloticus,Ictalurus punctatus,Takifugu rubripes,Cynoglossus semilaevis,Tachysurus fulvidraco,Micropogonias undulatus,Oryzias luzonensis,Horabagrus nigricollaris,Oryzias dancena,Homo sapiens,Mus musculus,Panthera tigris)
• Insulin signaling network that links nutrition to growth and size (2015, Drosophila melanogaster,Manduca sexta,Homo sapiens)
• Proposed mechanism for the male-specific heart phenotype in insulin-resistant Pcyt2+/− mice (2015, NA)
• USP18 negatively regulates NFKB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms (2015, NA)
• Upstream negative regulators of the Hippo pathway (2015, Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Gallus gallus)
• Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway (2015, NA)
• AD induced by i.c.v (2015, NA)
• A possible signaling pathway involved in opioid- and KATP channel-induced cardioprotection (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris)
• Interferon signaling upstream regulator pathway, with subcellular compartmentalization indicated (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis)
• An overview of the JAK/STAT signalling pathway (2015, Homo sapiens,Mus musculus)
• Complex interactions between intracellular cascades result in a unique pattern of astrocyte reactivity in ND (2015, NA)
• Main extracellular stimuli and intracellular signaling pathways leading to astrocyte reactivity in ND (2015, NA)
• Schematic overview of a potential I1 and adenosine receptors crosstalk (2015, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus)
• Conceptual model of general health factors, salient CHD pathogenetic pathways and CHD hallmarks (2015, Porphyromonas gingivalis,Homo sapiens)
• Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway (2015, NA)
• Analysis of Stress-Responsive Gene Expression in Cultivated and Weedy Rice Differing in Cold Stress Tolerance (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Triticum aestivum,Hordeum vulgare,Cicer arietinum,Populus trichocarpa,Vigna radiata,Oryza sativa Japonica Group,Oryza sativa Indica Group,Hyacinthus orientalis,Gymnocladus dioicus,Homo sapiens)
• Identification of Oxygen-Responsive Transcripts in the Silage Inoculant Lactobacillus buchneri CD034 by RNA Sequencing (2015, NA)
• Brca1 pathway is involved in microglia from hSOD1G93A mice (2015, NA)
• Schematic hypothesis about interleukin (IL)-13 synthesis induced through Smad and mitogen-activated protein kinase (MAPK) pathways in response to transforming growth factor (TGF)B in T cells of patients with systemic sclerosis (2015, NA)
• New working model (2015, NA)
• Regulation of hepcidin expression by iron and inflammation (2015, NA)
• Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARA expression (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Role for PI3KG signaling in core symptoms of ADHDPI3KG is abundant in noradrenergic neurons of the locus coeruleus (LC), which constitute the main source of noradrenaline in the brain (2015, Homo sapiens,Mus musculus)
• Signaling pathways implicated in the formation of vasculogenic mimicry (VM) networks (2015, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Cucumis sativus)
• Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos (2015, Homo sapiens,Danio rerio)
• Diagram summarizing our findings (2015, NA)
• Chemokine signaling pathway (2015, NA)
• Endocytosis signaling pathway (2015, NA)
• Lysosome signaling pathway (2015, NA)
• ERBB signaling pathway (2015, NA)
• MAPK signaling pathway (2015, NA)
• Proposed effects of salubrinal on the xenotoxicant-activated ER stress signaling pathways (2015, NA)
• Protein–protein interaction (PPI) network and ingenuity pathway analysis (IPA) (2015, Bos taurus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Moloney murine leukemia virus,Homo sapiens,Mus musculus,Melia azedarach,NA)
• NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages (2015, NA)
• Aop-Foxo Function Downstream of IISWe propose that, downstream of the insulin receptor substrate, Chico, signaling via the IIS pathway bifurcates into two branches: Ras-Erk and PI3K-Akt (2015, NA)
• The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity (2015, Homo sapiens,Drosophila melanogaster)
• Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst (2015, NA)
• B2-adrenergic signal transduction plays a detrimental role in subchondral bone loss of temporomandibular joint in osteoarthritis (2015, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Unfolded protein response (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Core components of the insulin signaling pathway (2015, Homo sapiens)
• Innate immune sensing of rhabdovirus infection (2015, NA)
• Cerebral nitric oxide represses choroid plexus NFKB-dependent gateway activity for leukocyte trafficking (2015, Mus musculus,Homo sapiens)
• Summary of the inhibitory effects of BSNXD on osteoclast differentiation.Notes: The suppression of BSNXD on RANKL-induced activation of the NFATc1 via ERA pathway is correlated with the inhibition of osteoclastogenesis (2015, Armoracia rusticana,herbal medicine,Lycium barbarum,Ziziphus jujuba,Rehmannia glutinosa,Epimedium brevicornu,Epimedium koreanum,Phellodendron amurense,Cuscuta chinensis,Anemarrhena asphodeloides,Alisma plantago-aquatica,Ziziphus jujuba var. spinosa,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Biochemical network of arachidonic acid metabolism (2015, NA)
• PTEN localization and interactions with representative partners (2015, NA)
• Crosstalk between hepatitis C virus and autophagy (2015, Homo sapiens,NA)
• Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity (2015, Homo sapiens,Nicotiana tabacum,clinical samples,NA)
• Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis (2015, NA)
• Short range signalling between germline stem cell and its niche (2015, Drosophila melanogaster,Oncopeltus fasciatus,Homo sapiens)
• Short range signalling between the germline stem cells and their niche, which consists of the hub cells and the cyst stem cells (2015, Drosophila melanogaster,Oncopeltus fasciatus,Homo sapiens)
• Sirt1 controls the immune responses in macrophages (2015, NA)
• Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway (2015, NA)
• Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway (2015, NA)
• Signal transduction pathways drive cancer metastasis (2015, NA)
• TLR diversity, ligands, and signaling (2015, NA)
• Representative scheme of the action of taurine in skeletal muscle fiber (2015, NA)
• Summary of the interactions between the PI3K/AKT pathway and RUNX2 with integration of the TGFB pathway (2015, NA)
• Proposed signaling pathways of PS1-induced apoptosis (2015, NA)
• Examples of IPA software outcome: hsa-let-7 and their target genes in Human Embryonic Stem Cell Pluripotency Pathway (2015, NA)
• Activation of JAK/STAT by IL-6 (2015, Homo sapiens,Bos taurus)
• Ramification of IFN signaling pathways leading to immunostimulatory and immunosuppressive regulation of macrophage polarization (2015, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Human betaherpesvirus 5,West Nile virus,Measles morbillivirus,Porcine reproductive and respiratory syndrome virus,Ebola virus sp.,Foot-and-mouth disease virus,Suid alphaherpesvirus 1,SARS coronavirus NS-1,Classical swine fever virus,African swine fever virus,Porcine circovirus 2,Homo sapiens,Mus musculus,Sus scrofa,Candida dubliniensis,NA,NA,NA)
• Differential activation of HIV-specific CD8+ T cells by native and heteroclitic peptides (2015, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Middle East respiratory syndrome-related coronavirus,Murine hepatitis virus,Homo sapiens,Mus musculus,Manduca sexta,Malacoplasma penetrans HF-2)
• Let-7 targets insulin signaling pathway and thus inhibits cancer cell metabolism (2015, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• PTGS pathway deregulation during colorectal tumorigenesis (2015, NA)
• Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease (2015, NA)
• Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease (2015, NA)
• Insulin and IGF-1 signaling in gray mouse lemursIR and IGF-IR share a similar signaling pathway which invokes downstream changes in two main branches – the mitogenic pathway (Ras/Raf/MEK/ERK) and the metabolic pathway (PI3K/Akt) (2015, NA)
• Glycogen Synthase Kinase 3A and B Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from Staphylococcus aureus (2015, Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pneumoniae,Brucella abortus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Human papillomavirus type 16,NA)
• Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Danio rerio,Adeno-associated virus,Sequoia sempervirens)
• Schematic diagram for signaling regulation of acetylcholinesterase (AChE) (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Nicotiana tabacum,Human gammaherpesvirus 8)
• Lf intervention upregulates the neurotrophin-signaling pathway in postnatal piglets (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Sus scrofa domesticus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Sequoia sempervirens,Pieris brassicae,Stenostomum lucidum,Homo sapiens,Corynebacterium phage gamma)
• Survivin (SVN) pathways to apoptosis (2015, NA)
• Trade-Off between Growth and Carbohydrate Accumulation in Nutrient-Limited Arthrospira sp. PCC 8005 Studied by Integrating Transcriptomic and Proteomic Approaches (2015, Arthrospira sp.)
• PI3K/AKT network in renal cancer samples (2015, NA)
• Map of the Wnt signaling pathway, which includes at least three Wnt signaling pathways, namely the canonical pathway, the planar cell polarity pathway and the Wnt/Ca2+pathway (2015, NA)
• BMI-1 is important in the regulation of cancer and CSCs, functioning through the activation of multiple signaling pathways (2015, NA)
• Signaling pathway of cell apoptosis under cordycepin stress (2015, NA)
• Signaling pathway of cell proliferation inhibition under cordycepin stress (2015, NA)
• Jak-Stat pathway of C (2015, NA)
• Toll signalling pathway of C (2015, NA)
• Transcripts regulating the Wnt signaling pathway are putatively affected by up-regulated miRNAs expression in the PCOS patients when compared with control (2015, NA)
• Neurons versus herpes simplex virus: the innate immune interactions that contribute to a host–pathogen standoff (2015, NA)
• HSV-I and the cellular DNA damage response (2015, Human alphaherpesvirus 1,Human betaherpesvirus 5,Adeno-associated virus,Betapolyomavirus macacae,adeno-associated virus 2,Mus musculus,Cricetus cricetus,Bacteriophage sp.,Lambdavirus lambda,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,NA)
• Uses of CRY2 domains (2015, NA)
• Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis (2015, NA)
• Chemical–protein interactions related to the VEGF signaling pathway (2015, herbal medicine,Matthiola incana,Epimedium brevicornu,Gynochthodes officinalis,Homo sapiens,Molva molva,Pan troglodytes,teleost fish,Rattus norvegicus,Canis lupus familiaris,H1N1 subtype)
• Illustration of known and hypothesized BR signaling pathway (2015, NA)
• Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma (2015, NA)
• Adaptation of a Bioinformatics Microarray Analysis Workflow for a Toxicogenomic Study in Rainbow Trout (2015, NA)
• The molecular events leading to the production of IL-10 in macrophages exposed to S (2015, Oryctolagus cuniculus,Capra hircus,Schistosoma mansoni,Panthera tigris,Schistosoma haematobium,Biomphalaria glabrata,Homo sapiens,Mus musculus,Candida dubliniensis)
• Molecular targeting of the mitogen-activated protein kinase (MAPK), PI3K, and CDK4 pathways and the associated mutation rates of potential molecular targets in advanced melanoma () (2015, Homo sapiens,Mus musculus)
• NAMPT inhibition leads to alterations of different metabolic pathways in cancer cells (2015, NA)
• CFZ inhibition of PTH-induced osteoclastogenesis (2015, NA)
• Schematic diagram showing the proposed mechanisms involved in transferring PUFAs from PC into TAG (2015, NA)
• ATRA-dependent regulation of genes belonging to the NOTCH pathway in SKBR3 cells (2015, NA)
• Proposed pathway based on data from the present study showing increased Nox4 expression in response to stretch (2015, NA)
• EGCG reverses human neutrophil elastase-induced migration in A549 cells by directly binding to HNE and by regulating A1-AT (2015, NA)
• Postulated signaling pathway for MMF through binding to HCAR2 (2015, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Spleen focus-forming virus)
• Results from a transcriptomic analysis of the OCM: Downregulated genes were, dependening on their level colored in green, upregulated in red (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,unidentified)
• EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer (2015, Homo sapiens,Mus musculus,Bos taurus,Eucalyptus intertexta,Tequatrovirus T4)
• Endocannabinoid system giving rise to endocannabinoids (2AG and AEA) and arachidonic acid and subsequently synthesis of prostaglandin glycerol esters, prostanoids, and prostamides (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Simplified overview of the biosynthetic pathway leading from ceramide to sphingosine-1-phosphate (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Schematic stages of the autophagic pathway (2015, Saccharomyces cerevisiae,Homo sapiens)
• Hypothesized model for the mechanism through which baicalein induces apoptosis and inhibits metastasis of prostate cancer cells (2015, Armoracia rusticana,Camellia sinensis,Scutellaria baicalensis,Scrophularia striata,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• TREMs signaling pathway during the course of immune-inflammatory response (2015, NA)
• Concept diagram depicting the potential transcriptional regulation of Nox by transcription factors and epigenetic mechanisms in vascular/immune cells in response to cardiovascular risk factors (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Biosynthesis pathway of neurotransmitters in insects (2015, Chilo suppressalis,Homo sapiens)
• Overlapping mechanisms of pesticide and ischaemia-reperfusion renal injury (2015, NA)
• Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells (2015, NA)
• UCB-MSC therapy is curative for IC bladder (2015, Homo sapiens,Rattus norvegicus)
• EphA2 Receptor Signaling Mediates Inflammatory Responses in Lipopolysaccharide-Induced Lung Injury (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Armoracia rusticana,Nicotiana tabacum,Capra hircus,Homo sapiens,Escherichia coli)
• Neuroprotective cross-talk involving the cytoprotective PI3K/AKT pathway (2015, Citrus x paradisi,Eucommia ulmoides,Clausena lansium,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Danio rerio)
• Schematic diagram depicting the possible signaling pathway induced by TMT in BV-2 cells (2015, NA)
• Cdc42-SRF signaling pathway regulates cytoskeletal genes that are important in the development and maintenance of cardiovascular structure and function (2015, NA)
• Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs (2015, NA)
• HPV pseudovirions enter the host epithelial cells (keratinocytes) by interacting with A6B4 integrin receptor or growth factor receptor to enhance cell proliferation through the activation of the PI3K/Akt/mTOR and PI3k signalling pathway (2015, Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,human papillomavirus 18,Alphapapillomavirus 7,Zaire ebolavirus,Poliovirus 2,Deltapapillomavirus 4,human papillomavirus 31,Poliovirus 1,Human papillomavirus KC5,Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Drosophila melanogaster,Corynebacterium phage gamma)
• Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer? (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Sclerostin actions (2015, NA)
• WNT pathway is significantly upregulated in invasive mutant TP53 cells (2015, NA)
• Vitamin D and its receptor (VDR) in the cytokine-mediated onset of depression (2015, NA)
• Redox signaling in ECs and role of MnSOD (2015, NA)
• MicroRNA regulation of lymphocyte tolerance and autoimmunity (2015, Homo sapiens,Mus musculus)
• AGE-RAGE interaction activates the PI3K/Akt pathway and enhances Rb phosphorylation and degradation (2015, NA)
• The action PI3K/Akt/mTOR pathway inhibitors in CSC (2015, NA)
• The PI3K/Akt/mTOR signaling pathway and CSC biology (2015, NA)
• Radiation-induced acetylated and deacetylated proteins (2015, Bos taurus,Gallus gallus,Danio rerio,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,NA)
• MiR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer (2015, NA)
• Epigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Diaporthe sclerotioides,Equus caballus,Eucalyptus intertexta,Homo sapiens)
• Inactivation of bone morphogenetic protein 2 may predict clinical outcome and poor overall survival for renal cell carcinoma through epigenetic pathways (2015, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Matthiola incana,Homo sapiens,clinical samples)
• Pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis (2015, NA)
• MicroRNAs in apoptosis, autophagy and necroptosis (2015, Hepatitis B virus,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,Pseudomonas aeruginosa 18A)
• MicroRNAs in apoptosis, autophagy and necroptosis (2015, Hepatitis B virus,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,Pseudomonas aeruginosa 18A)
• Secreted Frizzled-related proteins (sFrps) (2015, Mus musculus,Rattus norvegicus,Danio rerio,Lareunionomyces loeiensis,teleost fish,Melia azedarach,Homo sapiens,Drosophila melanogaster)
• Roles of Wnt/Beta-catenin signaling during vertebrate heart development (2015, Mus musculus,Rattus norvegicus,Danio rerio,Lareunionomyces loeiensis,teleost fish,Melia azedarach,Homo sapiens,Drosophila melanogaster)
• Wnt/Beta-catenin signaling pathway (2015, Mus musculus,Rattus norvegicus,Danio rerio,Lareunionomyces loeiensis,teleost fish,Melia azedarach,Homo sapiens,Drosophila melanogaster)
• Novel drug target identification for the treatment of dementia using multi-relational association mining (2015, NA)
• The flow of glucose carbons in the presence of added fructose in adipocytes (2015, NA)
• Signaling via the IGF-1R begins with binding of its ligands, IGF-1, IGF-2, or insulin, to the extracellular Alpha-subunit, and this in turn leads to phosphorylation of the intracellular Beta-subunits (2015, NA)
• Proposed scheme of Fyn-mediated neuroinflammatory signaling pathway in microglia (2015, NA)
• Current model for the role of the Pta-Ack pathway in S (2015, NA)
• Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells (2015, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells (2015, Hepatitis B virus,Homo sapiens)
• Emerging role of CaMKII in cancer (2015, NA)
• Dynamic transcriptome analysis and volatile profiling of Gossypium hirsutum in response to the cotton bollworm Helicoverpa armigera (2015, Helicoverpa armigera,Gossypium hirsutum)
• Schematic overview of ligand-stimulated SR signal transduction (2015, NA)
• Programmed cell death 1 (PD-1)/PD-L1 pathway (2015, Homo sapiens)
• FGF8 positively regulates ΔNp63A protein stability in mice embryonic limb buds (2015, NA)
• Differential expression of a core set of genes whose products comprise a functional interactome is an underlying feature of chronically wounded RPE cells (2015, NA)
• NetworkPainter enables researchers to quickly draw publication quality signaling diagrams (2015, NA)
• Deoxycytidine biosynthetic pathway (2015, Escherichia coli,Homo sapiens)
• Synergistic activity of polarised osteoblasts inside condensations cause their differentiation (2015, Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus,Oryzias latipes)
• Intracellular calcium and cell survival: Intracellular calcium activates the intermediate proteins in the signalling pathways in neuroblastoma (2015, NA)
• PP2A as a promoter of carcinogenesis (2015, Drosophila melanogaster,Caenorhabditis elegans,Mylabris cichorii,Mylabris phalerata,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Ovis aries,Betapolyomavirus macacae,Homo sapiens,NA)
• PP2A as a tumour suppressor in signaling pathways (2015, Drosophila melanogaster,Caenorhabditis elegans,Mylabris cichorii,Mylabris phalerata,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Ovis aries,Betapolyomavirus macacae,Homo sapiens,NA)
• Scheme representing the metabolic pathway of permethrin in rat liver (2015, NA)
• Muscle protein homeostasis in critical illness (2015, NA)
• Schematic diagraming central role of pyruvate in glycolytic, citric acid cycle (CAC), and accessory pathways (2015, Homo sapiens,Sus scrofa)
• In response to diverse biological stressors, macrophage migration inhibitory factor (MIF) is secreted from preformed intracytoplasmic pools (2015, Mus musculus,Homo sapiens)
• Targets of miRNAs in different cell types of developing mouse lungs (2015, NA)
• Multifactorial pathogenesis of primary Sjögren’s syndrome: interferons as culprits in the self-amplifying pathogenic loop (2015, NA)
• Regulation of JAG1-NOTCH1-uPA, Cyclin D-CDK4/6-p21-p27, and PI3K-PDK1-AKT1 cell signaling by members of the miR-23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR17~92, miR183~96~182, and miR-302s clusters (2015, NA)
• Regulation of CUL5, JAG-NOTCH, TNKS2, and PTEN-PI3K-AKT cell signaling by members of miR-17~92 and miR-106a~363 clusters in cervical cancer (2015, NA)
• Regulation of MAPK, PI3K-AKT, and G2-M checkpoint by members of the family miR-125 and members of miR-let-7c~99a, miR-125a~let-7e~99b, miR-100~let-7a-2, and miR-206~133b clusters in cervical cancer (2015, NA)
• Tryptophan metabolism through the kynurenine pathway (2015, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis BCG str. Moreau,Homo sapiens,Human immunodeficiency virus 1,Bromus secalinus,NA)
• Proposed signalling pathway linking impaired nitric oxide bioavailability to PDE3 function (2015, Mus musculus,Homo sapiens)
• Integrated analysis of alterations in key pathways in nccRCC subtypes (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Hepatitis B virus,Fragaria x ananassa,NA)
• EDA pathway and its downstream signaling (2015, NA)
• Output of a fictitious combination of gene expression and mutations in version of the Calcium signaling pathway modified for illustrating the examples (2015, NA)
• Pterin-dependent DcpA regulation (2015, NA)
• Hepatic lipid homeostasis is regulated by LRP6 (2015, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Proposed model of the vitamin D-dependent antimicrobial pathway (2015, NA)
• Signaling pathways of the endoplasmic reticulum (ER) stress response (2015, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Dengue virus,Middle East respiratory syndrome-related coronavirus,Respiratory syncytial virus,Vesicular stomatitis virus,West Nile virus,Enterovirus C,Japanese encephalitis virus,Coxsackievirus,Murine hepatitis virus,Foot-and-mouth disease virus,Yellow fever virus,Infectious bronchitis virus,SARS coronavirus NS-1,Murine coronavirus,Transmissible gastroenteritis virus,Classical swine fever virus,Influenza B virus,JC polyomavirus,SARS coronavirus LC3,Bovine rotavirus,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Xenopus laevis,NA,NA)
• Hierarchical signaling pathway expression regulates regeneration (2015, Gallus gallus,Danio rerio,Xenopus laevis,Dipturus trachyderma,teleost fish,Xenopus tropicalis,Ambystoma mexicanum,Tetrapoda,Notophthalmus viridescens,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• The HH signaling pathway (2015, Gallus gallus,Danio rerio,Xenopus laevis,Dipturus trachyderma,teleost fish,Xenopus tropicalis,Ambystoma mexicanum,Tetrapoda,Notophthalmus viridescens,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin (2015, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Ovis aries,Cricetulus migratorius,Homo sapiens,Staphylococcus aureus)
• Scheme illustrating the signaling pathway involved in the production of chemokines and cytokines induced by prostaglandin F2A (PGF2A) (2015, Homo sapiens)
• Ephrin receptor signaling pathway (genes hypomethylated in the schizophrenia patient of Twin Pair 1) (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus)
• Signaling of SGK3 and AKT (2015, NA)
• Molecular architecture of the SEA complex (2015, Homo sapiens,Saccharomyces cerevisiae)
• Amino acid sensing in yeast and mammals at the vacuole or lysosome (2015, Homo sapiens,Saccharomyces cerevisiae)
• BRAF gene: From human cancers to developmental syndromes (2015, Homo sapiens,Mus musculus,Panthera pardus)
• Ingenuity Pathways Analysis summary (2015, NA)
• Apoptosis: role in myeloid cell development (2015, NA)
• OFE treatment counteracted TGFB1-activated SMAD pathways (2015, Citrus reticulata,Homo sapiens)
• Regulation of the interleukin (IL)–17 axis is essential for oral immunity and homeostasis (2015, NA)
• Patritumab and HER3 signaling pathway (2015, NA)
• Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome (2015, NA)
• Cell adhesion molecules (CAMs) pathway (2015, NA)
• Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction (2015, NA)
• Hypoxia-inducible factor 1A (HIF-1A) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1A/CXCR4 pathway in non-small cell lung carcinoma cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Genetic/molecular alterations of meningiomas and the signaling pathways targeted (2015, NA)
• Serum C1 competes with Wnt for Fz receptor binding, resulting in Wnt canonical pathway activation (2015, Escherichia coli,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Klebsiella pneumoniae,Streptococcus pyogenes,Streptococcus pneumoniae D39,Listeria monocytogenes Italy,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Human immunodeficiency virus 1,Ovis aries,Human immunodeficiency virus,Human T-cell leukemia virus type I,Neacomys sp.,Candida dubliniensis,Lareunionomyces loeiensis,Homo sapiens,prion,Trypanosoma cruzi,Prionace glauca,NA)
• Key signals mediating progenitor fate decisions during hepatogenesis (2015, NA)
• Three pathways of complement activation (2015, NA)
• Metformin on hepatocyte energy status and the mammalian target of rapamycin pathway, in turn affecting metabolism and inflammation (2015, Homo sapiens,Hepatitis B virus)
• Engineered pathways for the production of FABCEs (2015, Saccharomyces cerevisiae,Escherichia coli,Zea mays,Glycine max,Bacillus subtilis,Komagataella pastoris,Escherichia coli BL21,Rhodotorula toruloides,Acinetobacter baylyi ADP1,Acinetobacter baylyi,Komagataella phaffii GS115,Bacillus sp. AN,Homo sapiens)
• Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation (2015, NA)
• Metabolic Profiles in Ovine Carotid Arteries with Developmental Maturation and Long-Term Hypoxia (2015, NA)
• Computational Modelling of NFKB Activation by IL-1RI and Its Co-Receptor TILRR, Predicts a Role for Cytoskeletal Sequestration of IKBA in Inflammatory Signalling (2015, NA)
• Ratio of transcripts and metabolite levels in the glutathione-ascorbate cycle and the glutathione peroxidase cycle in Gb and Gh fiber (2015, Arabidopsis thaliana,Oryza sativa,Solanum lycopersicum,Diaporthe sclerotioides,Embryophyta,Magnoliopsida,Phaseolus vulgaris,Gossypium hirsutum,Picea abies,Spermatophyta,Gossypium raimondii,Gossypium barbadense,Gossypium arboreum,Gossypium herbaceum,Selaginella lepidophylla,Geum montanum,Homo sapiens,Rattus norvegicus)
• Diagram indicating the pathway involved in AngII and TRPV1 signalling, with activation of p38 (MAPK) and p44/42 (ERK) and their inhibition by EMA401 in DRG neurons (2015, NA)
• Rewired upstream transcription subnetwork in regulating the downstream pentose phosphate pathway in biomass conversion in Y-50049 yeast strain versus the wild-type (2015, NA)
• Rewired transcription network regulating metabolic pathways for tolerant industrial yeast Saccharomyces cerevisiae NRRL Y-50049 (2015, NA)
• The cell signal pathway involved in the SLY-induced inflammatory response in PBMCs (2015, NA)
• miR-93 Promotes Cell Proliferation in Gliomas through Activation of PI3K/Akt Signaling Pathway (2015, NA)
• HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation (2015, NA)
• Targeting AMPK for cancer prevention and treatment (2015, Saccharomyces cerevisiae,Nicotiana tabacum,Candida dubliniensis,Olea europaea,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis (2015, NA)
• Folate metabolic pathway (2015, Homo sapiens,Escherichia coli,Triticum aestivum,Meleagris gallopavo)
• Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases (2015, Homo sapiens,Rattus norvegicus)
• PI3K-C2G is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling (2015, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Armoracia rusticana)
• Gut-brain axis for the actions of glucagon-like peptide-1 (2015, NA)
• Gene co-expression network of the 48 genes in the peroxisome proliferator-activated receptor pathway based on their expression values (2015, NA)
• DNA damage-induced p53 pathway and how other tumor suppressors are connected to activate cell cycle arrest, senescence, or apoptosis to prevent cellular transformation (2015, Human T-cell leukemia virus type I,Human T-lymphotropic virus 2,Homo sapiens,Mus musculus)
• Mitogen-activated protein kinase (MAPK) signalling pathway (2015, NA)
• Cooperative disruption of signaling network downstream of mutated KRAS (2015, NA)
• Nrf2/ARE pathway and cAMP second messenger system together are the key regulators of cellular antioxidant defence (2015, NA)
• Receptor-dependent mechanisms that allosterically activate protein kinase C (PKC) (2015, NA)
• Illustration of vomeronasal neuron signaling pathway (2015, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens)
• From metabolism to epigenetic remodeling (2015, NA)
• Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties (2015, NA)
• Schematic diagram depicting Brd4 mediated signaling pathway in Pkd1 mutant renal epithelial cells (2015, NA)
• COX-2 increases insulin signaling by downregulation of miR-183 (2015, Homo sapiens,Mus musculus)
• UPR signaling schematic (2015, NA)
• Mechanism of action of paclitaxel (2015, NA)
• REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination (2015, NA)
• Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity (2015, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Manduca sexta,Acyrthosiphon pisum,Culex quinquefasciatus,Tenebrio molitor,Trichoplusia ni,Helicoverpa zea,Anopheles quadrimaculatus,Heliothis virescens,Diaphorina citri,Procambarus clarkii,Wuchereria bancrofti,Pediculus humanus corporis,Bactericera cockerelli,Pediculus humanus capitis,Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Vibrio cholerae,Bacillus thuringiensis,Candidatus Liberibacter asiaticus,Xylella fastidiosa,Paenibacillus larvae,Paenibacillus larvae subsp. larvae,Candidatus Carsonella ruddii,Candidatus Liberibacter solanacearum,Klebsiella sp. F51-1-2,Diaporthe sclerotioides,Solanum tuberosum,Citrus x paradisi,Phragmites australis,Homo sapiens,Dengue virus,metagenome,Cervus elaphus)
• Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity (2015, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Manduca sexta,Acyrthosiphon pisum,Culex quinquefasciatus,Tenebrio molitor,Trichoplusia ni,Helicoverpa zea,Anopheles quadrimaculatus,Heliothis virescens,Diaphorina citri,Procambarus clarkii,Wuchereria bancrofti,Pediculus humanus corporis,Bactericera cockerelli,Pediculus humanus capitis,Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Vibrio cholerae,Bacillus thuringiensis,Candidatus Liberibacter asiaticus,Xylella fastidiosa,Paenibacillus larvae,Paenibacillus larvae subsp. larvae,Candidatus Carsonella ruddii,Candidatus Liberibacter solanacearum,Klebsiella sp. F51-1-2,Diaporthe sclerotioides,Solanum tuberosum,Citrus x paradisi,Phragmites australis,Homo sapiens,Dengue virus,metagenome,Cervus elaphus)
• Asian Citrus Psyllid Expression Profiles Suggest Candidatus Liberibacter Asiaticus-Mediated Alteration of Adult Nutrition and Metabolism, and of Nymphal Development and Immunity (2015, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Manduca sexta,Acyrthosiphon pisum,Culex quinquefasciatus,Tenebrio molitor,Trichoplusia ni,Helicoverpa zea,Anopheles quadrimaculatus,Heliothis virescens,Diaphorina citri,Procambarus clarkii,Wuchereria bancrofti,Pediculus humanus corporis,Bactericera cockerelli,Pediculus humanus capitis,Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Vibrio cholerae,Bacillus thuringiensis,Candidatus Liberibacter asiaticus,Xylella fastidiosa,Paenibacillus larvae,Paenibacillus larvae subsp. larvae,Candidatus Carsonella ruddii,Candidatus Liberibacter solanacearum,Klebsiella sp. F51-1-2,Diaporthe sclerotioides,Solanum tuberosum,Citrus x paradisi,Phragmites australis,Homo sapiens,Dengue virus,metagenome,Cervus elaphus)
• BMRF-MI: integrative identification of protein interaction network by modeling the gene dependency (2015, Homo sapiens,Saccharomyces cerevisiae)
• Biochemical pathways (2015, NA)
• The differential subversion of type I IFN and mitochondrial apoptotic pathway by LCMV (2015, Homo sapiens,Mus musculus,NA)
• Human Blood Metabolome-Transcriptome Interface (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Oncorhynchus mykiss)
• Functional relations of differentially expressed genes with each other and with members of important pathways, as displayed by FunCoup online resource (2015, NA)
• Evidence for Immune Response, Axonal Dysfunction and Reduced Endocytosis in the Substantia Nigra in Early Stage Parkinson’s Disease (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Elementary Flux Mode Analysis Revealed Cyclization Pathway as a Powerful Way for NADPH Regeneration of Central Carbon Metabolism (2015, Escherichia coli,Pseudomonas aeruginosa,Corynebacterium glutamicum,Pseudomonas fluorescens,Clostridium acetobutylicum,Gluconobacter oxydans 621H,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Lineage specific differentiation for MSCs in an exquisitely coordinated process with critical regulators and indicators are shown (2015, Gallus gallus,Xenopus laevis,Xenopus tropicalis,Eucalyptus intertexta,Citrus aurantiifolia,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human gammaherpesvirus 4)
• BMP signaling and its regulation (2015, Gallus gallus,Xenopus laevis,Xenopus tropicalis,Eucalyptus intertexta,Citrus aurantiifolia,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human gammaherpesvirus 4)
• TLR4 signalling pathway to alleviate microglial activation (2015, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Armoracia rusticana,NA,Homo sapiens)
• Wnt/Beta-catenin signaling pathway (2015, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Therapeutic potential of targeting IL-17-mediated pathway (2015, Lareunionomyces loeiensis,Candida albicans,Candida albicans 23R,Candida albicans 23P,Staphylococcus aureus,Staphylococcus epidermidis,Staphylococcus aureus 7-B-1,Homo sapiens,Mus musculus,Saimiriine gammaherpesvirus 2)
• Pentose phosphate pathway (PPP) in neuronal energy metabolism (2015, NA)
• Pentose phosphate pathway (PPP) is associated with several cancer- and cell-proliferation-related signalling cascades (2015, NA)
• Stress-Immune-Growth Interactions: Cortisol Modulates Suppressors of Cytokine Signaling and JAK/STAT Pathway in Rainbow Trout Liver (2015, NA)
• Complement cascades (2015, NA)
• Signaling pathway triggered by myocardial stretch leading to Anrep Effect or slow force response (SFR) (2015, NA)
• JAK-STAT signalling pathway (2015, NA)
• TNF signalling pathway (2015, NA)
• Toll-like receptor signalling pathway coverage (2015, NA)
• Carbon-catabolic pathways in S (2015, NA)
• Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis (2015, NA)
• NFKB pathway (2015, Curcuma longa,Agaricus bisporus,Isodon japonicus,Acacia victoriae,Homo sapiens,Mus musculus)
• CpxRA two-component signal transduction system () (2015, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Haemophilus ducreyi,Homo sapiens,Mus musculus)
• Major pathways for the metabolism of IFO (2015, Homo sapiens,Rattus norvegicus)
• Illustration for the mechanism underlying s-IL-15RA–induced EMT, migration, and invasion of human RCCs (2015, NA)
• Influence of the inflammatory cytokines on the status of insulin resistance (2015, NA)
• KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Scheme of possible mechanisms by which AT-101 enhances the anticancer activity of CDDP in NSCLC (2015, Mus musculus,Rattus norvegicus,Armoracia rusticana,Sesamum indicum,Homo sapiens,Bos taurus,Polyomavirus sp.)
• Cellular regulation mediated by extracellular matrix (ECM).Notes: The action of ECM components on the major signaling pathways of tyrosine kinase receptors, their links, and the outcome on tumor cell and chemotherapeutic response (2015, Homo sapiens,Mus musculus,Caenorhabditis elegans,Malus domestica,Calloplesiops altivelis)
• EMT process and signaling pathway (2015, NA)
• Proposed schema of the pathways underlying renal protection conferred by xenon (Xe) preconditioning (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer (2015, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Oryctolagus cuniculus,clinical samples,Avian retroviruses)
• EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma (2015, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Adeno-associated virus,Homo sapiens,Bos taurus)
• Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery (2015, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery (2015, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Epithelial–mesenchymal interactions mediated by Sonic Hedgehog pathway in embryonic lung (2015, NA)
• New chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras (2015, NA)
• Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1 (2015, NA)
• Ghrelin receptor controls obesity by fat burning (2015, NA)
• Identified molecular targets involved in ELFEF-induced enhancement of adult hippocampal neurogenesis and osteogenesis (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathologic role of TCR, BCR and TH17-induced MALT-1 in demyelination and the inhibition of this signaling pathway by A20 (2015, NA)
• Schematic model of the molecular mechanisms associated with PD-induced autophagy in NCI-H460 and A549 cells (2015, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Platycodon grandiflorus,Homo sapiens,Mus musculus)
• Proposed signaling pathways of IHP-induced DLDH upregulation via the cAMP/CREB signaling pathway (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Homo sapiens,Human immunodeficiency virus 1)
• CAE-stimulated antioxidant enzyme and insulin secretion pathway in pancreatic Beta-cells in HG and H2O2 stress conditions (2015, NA)
• Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells (2015, Armoracia rusticana,Fucus vesiculosus,Homo sapiens,Mus musculus,Bos taurus)
• Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,H1N1 subtype)
• Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,H1N1 subtype)
• Long-Term Mild, rather than Intense, Exercise Enhances Adult Hippocampal Neurogenesis and Greatly Changes the Transcriptomic Profile of the Hippocampus (2015, NA)
• Integrated regulatory graph was constructed as a prediction for the regulatory pathway of IMP metabolism (2015, NA)
• Maturation and secretion of IL-1B requires two signals (2015, Leucanthemum maximum,Rhododendron maximum,Homo sapiens,Mus musculus)
• Hyperglycemia-induced endothelial dysfunction (2015, NA)
• MAPK signaling pathway and neurotrophin signaling pathway maps (2015, NA)
• Lipid biosynthetic pathways and interactions of phospholipid synthases and proteins involved in cell division (2015, Escherichia coli,Staphylococcus aureus,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Enterococcus faecalis,Streptococcus pyogenes,Escherichia coli IS1,Escherichia coli str. K-12 substr. MG1655,Cereibacter sphaeroides,Bacillus subtilis subsp. subtilis str. 168,Caulobacter vibrioides,Micrococcus luteus,Thermotoga maritima,Bacillus subtilis subsp. subtilis,Streptococcus pneumoniae D39,Escherichia coli NC-7,Shewanella livingstonensis,Diaporthe sclerotioides,Prioria balsamifera,Homo sapiens,Hypostomus robinii,minichromosomes,Sigma virus)
• Most possible acting pathway of p42.3 protein by optimization of Bayes theorem (2015, NA)
• Primary regulatory networks (2015, NA)
• Glycosylation pathway defects with known immunologic consequences (2015, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Homo sapiens,Mus musculus,NA)
• Targeting cancer with kinase inhibitors (2015, NA)
• Targeting cancer with kinase inhibitors (2015, NA)
• MEL-18 loss mediates estrogen receptor–A downregulation and hormone independence (2015, NA)
• Different mechanisms of AAS neurotoxicity (2015, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Caenorhabditis elegans,Antarctothoa delta,Homo sapiens)
• Fanconi Anemia Pathway (2015, Homo sapiens,Mus musculus,NA)
• p38 MAPK signaling in osteoclasts (2015, NA)
• p38 MAPK signaling in osteoblasts (2015, NA)
• p38 MAPK signaling in chondrocytes (2015, NA)
• Mammalian cells employ two principal DNA double-strand break (DSB) repair pathways (2015, NA)
• Noncanonical Wnt5a signalling: a simplified view (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Dual function of genes (2015, NA)
• Dual function of TAK1 (2015, NA)
• Wnt/Beta-catenin pathway regulates stem cell pluripotency and cell fate decisions during development (2015, NA)
• Recently identified drivers in signaling pathways involved in adrenal tumorigenesis (2015, NA)
• The role of Sag in regulation of KrasG12D-induced papillomagenesis (2015, NA)
• Comparative Transcriptome Analysis Reveals the Influence of Abscisic Acid on the Metabolism of Pigments, Ascorbic Acid and Folic Acid during Strawberry Fruit Ripening (2015, Arabidopsis thaliana,Oryza sativa,Zea mays,Solanum lycopersicum,Solanum tuberosum,Fragaria x ananassa,Prunus persica,Musa acuminata,Fragaria vesca,Fragaria vesca subsp. americana,Vitis rotundifolia,Cistus albidus,Homo sapiens)
• Risk loci of human autoimmune diseases associated with the TFH developmental pathway (2015, NA)
• Effect of sclerostin inhibition on Wnt signaling.Notes: Sclerostin is secreted by the osteocyte (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Mouse mammary tumor virus,Dipturus trachyderma)
• Wnt signaling pathways and the biology of sclerostin.Notes: (A) Canonical Wnt signaling: in the absence of sclerostin, Wnt binds to LRP 5/6 and its co-receptor, frizzled (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Mouse mammary tumor virus,Dipturus trachyderma)
• Scheme for producing fatty acid-derived biofuels in yeast (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Triticum aestivum,Yarrowia lipolytica,Ricinus communis,Melia azedarach,Kluyveromyces lactis,Panicum virgatum,Saccharomyces cerevisiae BY4741,Mortierella alpina,Rhodotorula diobovata,Rhodotorula babjevae,Escherichia coli,Bacillus subtilis,Streptococcus mutans,Corynebacterium ammoniagenes,Molva molva,Tyto alba,Mus musculus,Homo sapiens)
• Purine metabolic pathway (2015, Homo sapiens,Mus musculus,Danio rerio,Zea mays)
• Schema of a potential pathophysiologic pathway to superficial erosion as a cause of thrombotic complications of atherosclerotic plaques (2015, Homo sapiens)
• Role of ceramides in neuronal apoptosis (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,prion)
• Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile (2015, Dillenia suffruticosa,Homo sapiens)
• Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment (2015, NA)
• Crosstalk between growth factor and adhesion protein signaling (2015, NA)
• Mechanism of synergy between NFV and mTOR inhibitors (2015, Human immunodeficiency virus 1,Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris,Plasmodium falciparum,NA)
• Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer (2015, NA)
• Negative feedback cross talk between PI3KA/Akt and NFKB signaling pathway by a local brief stimulation of TLR9, a potent preconditioning tool for programming the subsequent responses to I/R injuries and stimulation by TLR2, TLR4, or TLR5 ligands (2015, NA)
• All TLRs signal through the common MyD88-dependent pathway (2015, NA)
• Spinal cord NMDA receptor-mediated activation of mTOR signaling in cancer pain (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Hylobates sp.,Saccharomyces cerevisiae)
• Schematic of HER3 engagedment in heterodimerization and signaling (2015, NA)
• Cell model illustrates B2-adrenergic and insulin-mediated regulatory pathways for K+uptake (2015, NA)
• Molecular genetic model (adapted from ; ; ; ) (2015, NA)
• Regulation pathway from HBV infection to complement activation (2015, Hepatitis B virus,Human gammaherpesvirus 4,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,Armoracia rusticana)
• Activation of the cytokine-cytokine receptor interaction pathway in incubations with BL21 or W3110 (2015, NA)
• The signalling pathways implicated in fusion-positive ARMS progression (2015, NA)
• Fragile X Mental retardation protein regulates several cellular functions in the dendritic spine (2015, Agaricus bisporus,Raphanus sativus,Brassica napus subsp. rapifera,Mus musculus,Rattus norvegicus,Merluccius merluccius,Lavinia exilicauda,Homo sapiens,Drosophila melanogaster)
• Wnt/Beta-catenin signalling pathway (2015, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• IFN pathway in response to virus infection at 24 hpi (2015, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,H1N1 subtype,West Nile virus,H5N1 subtype,Influenza A virus H3N2,Avian myeloblastosis virus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens,Anas platyrhynchos,NA)
• The effects of hrHPV on NFKB signaling (2015, NA)
• TGFB signaling (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mustela lutreola)
• Types I and III IFNs canonical signaling pathways (2015, NA)
• Diagrammatic representation of the compartmentalization of the leucine amino acid biosynthetic pathway of S (2015, Saccharomyces cerevisiae,Homo sapiens)
• Putative inhibitory pathway of the AP-SF-mediated anti-inflammatory response (2015, Saccharomyces cerevisiae,Panax ginseng,Cinnamomum camphora,Vigna angularis,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,prion)
• UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1 (2015, NA)
• Interaction among Beta-catenin, Lef/Tcf transcription factors, and VDR (2015, NA)
• Schematic illustration of the transduction of signals from inflammatory bone diseases to brain-resident microglia through the leptomeninges and two different pathways for the IL-1B production activated by CGA and AB in microglia (2015, NA)
• Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing (2015, NA)
• Wnt/Beta-catenin signaling pathway (2015, NA)
• Notch signaling pathway (2015, NA)
• Schematic illustrations of a double-negative feedback loop and the ceRNA pathway (2015, Homo sapiens,Mus musculus)
• TLRs in human gastrointestinal pathology: health condition and inflammation (2015, Escherichia coli,Salmonella enterica,Bacteroides fragilis,Campylobacter jejuni,Borreliella burgdorferi,Faecalibacterium prausnitzii,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Candida dubliniensis)
• Functions of lncRNAs in autoimmune cells, T cells, B cells, macrophages, NK, and dendritic cells (2015, NA)
• Regulation of the alternative pathway (2015, NA)
• Complement during infection with a pathogen (2015, NA)
• Back from the dead; the curious tale of the predatory cyanobacterium Vampirovibrio chlorellavorus (2015, Vampirovibrio chlorellavorus,Escherichia coli,Agrobacterium tumefaciens,Enterococcus faecalis,Synechocystis sp. PCC 6803,Synechocystis sp.,Acinetobacter baumannii,Neisseria meningitidis,Caulobacter vibrioides,Pasteurella multocida,Staphylococcus aureus 1-B-1,Xanthomonas campestris pv. campestris,Nostoc punctiforme,Herpetosiphon aurantiacus,Bdellovibrio bacteriovorus,Candidatus Obscuribacter phosphatis,Nitrosomonas eutropha,Agromyces ramosus,Micavibrio aeruginosavorus,Saprospira grandis str. Lewin,PX clade,metagenome,environmental samples,Chlorella vulgaris,Homo sapiens,Chlorella virus,NA)
• Estrogen regulates cell adhesion and polarization signaling pathway of osteoclasts (2015, Homo sapiens,Mus musculus,Bos taurus,Neisseria meningitidis)
• Estrogen regulates MAPK signaling pathway of osteoclasts (2015, Homo sapiens,Mus musculus,Bos taurus,Neisseria meningitidis)
• Estrogen regulates apoptosis signaling pathway of osteoclasts (2015, Homo sapiens,Mus musculus,Bos taurus,Neisseria meningitidis)
• Estrogen regulates TNFA NFKB signaling pathway of osteoclasts (2015, Homo sapiens,Mus musculus,Bos taurus,Neisseria meningitidis)
• Estrogen regulates osteoclasts signaling pathway of osteoclasts (2015, Homo sapiens,Mus musculus,Bos taurus,Neisseria meningitidis)
• Transferrin endocytosis and signaling pathways in protozoan parasites (2015, Plasmodium falciparum,Trypanosoma cruzi,Trypanosoma brucei,Leishmania major,Leishmania donovani,Entamoeba histolytica,Leishmania mexicana,Leishmania infantum,Glossina morsitans,Leishmania braziliensis,Trypanosoma brucei gambiense,Leishmania chagasi,Leishmania tropica,Euglenozoa,Staphylococcus aureus,Streptococcus pneumoniae,Staphylococcus epidermidis,Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus,PX clade,Gadus morhua)
• Mechanisms underlying the developmental programming of NAFLD (2015, NA)
• Significant signaling pathway networks mined from phosphotyrosine-containing proteins in a glioblastoma tissue (2015, NA)
• Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex (2015, NA)
• Visualized thrombosis network (2015, NA)
• Stepwise overview of the mechanisms of sprouty and SPRED negative regulation of FGF signalling (2015, NA)
• Inactivation of a GAs-PKA tumor suppressor pathway in skin stem cells initiates basal-cell carcinogenesis (2015, Simian endogenous retrovirus,Woolly monkey sarcoma virus,Homo sapiens,Mus musculus,Bos taurus,Zea mays)
• Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy (2015, Homo sapiens)
• Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy (2015, Homo sapiens)
• Simultaneous Inference of Cancer Pathways and Tumor Progression from Cross-Sectional Mutation Data (2015, NA)
• How Exercise May Amend Metabolic Disturbances in Diabetic Cardiomyopathy (2015, NA)
• Metabolic Alterations Induce Oxidative Stress in Diabetic and Failing Hearts: Different Pathways, Same Outcome (2015, Homo sapiens)
• Metabolic Alterations Induce Oxidative Stress in Diabetic and Failing Hearts: Different Pathways, Same Outcome (2015, Homo sapiens)
• Pathway map visualizing metabolite changes in maize seeds resulting from the genetic engineering of carotenoid biosynthesis (2015, NA)
• Schematic model illustrating the possible pathway targeting NCI-H929 cell by HM910 (2015, Homo sapiens,Mus musculus)
• TGFB signaling in gliomagenesis and its targeting (2015, NA)
• Activation of canonical (Wnt–Beta-catenin) pathway (2015, NA)
• Trans-Activation between EphA and FGFR Regulates Self-Renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2A (2015, NA)
• Signaling pathways through which macrophages regulate Beta-cell replication (2015, NA)
• Drosophila Hippo pathway (2015, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus)
• Pathway analysis showed a strong role for early response genes and sterol regulatory elements (2015, Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Aeromonas hydrophila,Staphylococcus aureus 1-B-1,Staphylococcus aureus 7-B-1,Escherichia coli M15,Homo sapiens,Mus musculus,Bos taurus,Human papillomavirus,Penicillium citrinum)
• Schematic diagram showing the modulation of insulin-mediated glucose uptake in muscle cells by CRFR2 signaling pathway (2015, Homo sapiens,Mus musculus)
• 12-LO pathway in the Beta-cell (2015, NA)
• Visinets: A Web-Based Pathway Modeling and Dynamic Visualization Tool (2015, NA)
• Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFKB Signaling in Hepatocellular Carcinoma (2015, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Arabidopsis thaliana,Homo sapiens,Mus musculus)
• GABAB receptor upregulates fragile X mental retardation protein expression in neurons (2015, NA)
• Illustration of protein modification by the ubiquitin proteasome system (2015, NA)
• In cancer, glycolytic flux is increased through upstream parts of the glycolytic pathway up to pyruvate kinase and then decreased from pyruvate kinase downward, thereby generating a ‘bottleneck’ (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Gallus gallus,NA)
• Intracellular mechanisms activated by leucine (2015, Mus musculus,Rattus norvegicus,Phodopus sungorus,Homo sapiens,Zea mays,gut metagenome)
• Dihydroaustrasulfone Alcohol in regulating PDGF-BB-induced VSMC proliferation and migration (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Complement activation pathways and their regulators (2015, Homo sapiens)
• Stem cell response to matrix stiffness by integin, cytoskeleton and signal transduction crosstalk (2015, Homo sapiens)
• Predicted interactions between miRNA and mRNA targets within addiction relevant signaling pathways (2015, Mus musculus,Rattus norvegicus,Sequoia sempervirens,Raphanus sativus,Homo sapiens,Equus caballus)
• Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists’ arsenal (2015, NA)
• Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis (2015, Homo sapiens)
• Network between MAPK signaling pathway-related genes and miRNAs (2015, NA)
• Schematic presentation of testosterone-activated extra-nuclear signaling pathways (2015, Homo sapiens)
• Roles for Teneurins at diverse synapses (2015, NA)
• Mitochondrial complex I dysfunction in patients with BD could lead to increased release of superoxide anions, resulting in greater reactive oxygen species (ROS) production (2015, NA)
• Function of the Chondrocyte PI-3 Kinase-Akt Signaling Pathway is Stimulus Dependent (2015, Homo sapiens)
• Whole-Transcriptome Analysis of Differentially Expressed Genes in the Vegetative Buds, Floral Buds and Buds of Chrysanthemum morifolium (2015, NA)
• Illustration of the Hedghog (Hh) signalling activation (2015, Homo sapiens)
• Crosstalk between complement and TLR pathways (2015, NA)
• Role of complement in physiology (2015, NA)
• CD44 interferes with apoptosis resistance in HSC/LIC (2015, NA)
• Schematic model of preconditioning-induced neuroprotection (2015, Mus musculus,Rattus norvegicus,Vasconcellea candicans,Tacca leontopetaloides,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Glycemia-associated epigenetic mechanisms involved in NF-kB proinflammatory activity (2015, Homo sapiens,Mus musculus)
• Schematic overview of the 7TM receptors judged to be either stimulating (in green to the right) or inhibiting (red or orange to the left and top) ghrelin secretion directly on the ghrelin cell (2015, NA)
• Working model (2015, Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus,Caenorhabditis elegans,Capra hircus,Cavia porcellus,Homo sapiens,Gallus gallus,Matthiola incana)
• Changes in the expression of cell cycle-related genes during MNV-1 infection (2015, NA)
• Different signaling pathways activated by H2S showing the cardioprotective effects (2015, NA)
• Schematic summarization for the signaling mechanisms of the antifibrotic effects of H2S (2015, NA)
• Results from validation screens for Listeria infection (2015, NA)
• Scheme of the IL-11/STAT3/CDX2 pathway (2015, NA)
• Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation (2015, Armoracia rusticana,Areca catechu,Homo sapiens,Bos taurus)
• EGFR/ErbB3 Pathway Acts as a Compensatory Survival Mechanism upon c-Met Inhibition in Human c-Met+ Hepatocellular Carcinoma (2015, Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Fangchinoline inhibits the growth and invasive potential of gastric cancer cells by inhibiting the PI3K/Akt pathway (2015, NA)
• Activation and targeting of prosurvival pathways mediating FLT3 resistance (2015, NA)
• DA-Raf-Mediated Suppression of the Ras—ERK Pathway Is Essential for TGFB1-Induced Epithelial—Mesenchymal Transition in Alveolar Epithelial Type 2 Cells (2015, NA)
• TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation (2015, Bos taurus,Oryctolagus cuniculus,vectors,murine stem cell retroviral vector,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Human gammaherpesvirus 4,Streptococcus pyogenes,NA)
• Chlamydia pneumoniae Inclusion Membrane Protein Cpn1027 Interacts with Host Cell Wnt Signaling Pathway Regulator Cytoplasmic Activation/Proliferation-Associated Protein 2 (Caprin2) (2015, NA)
• Summary of Ingenuity Pathway Analysis (IPA) (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Mus musculus,Emmelichthys struhsakeri)
• Class I PI3K pathway (2015, Homo sapiens)
• Calcium channels in T cells (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Listeria monocytogenes,Capsicum frutescens,Dendroaspis polylepis polylepis,NA)
• Diagram summarizing KMUP-1 amelioration of 5-HT-induced K+ channel inhibition in PASMCs (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Detailed self-regulation scheme of cancer development in ERG+ well differentiated tumor samples (2015, NA)
• Distinct TGFB–dependent signaling pathways cause characteristic glomerular changes in DN (2015, Homo sapiens,Mus musculus)
• GPCR (or GPR) signaling in the regulation of Beta-cell proliferation (2015, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,vectors)
• Cadherin and integrin signaling pathways (2015, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,vectors)
• Cytokine and hormone signaling through JAK-STAT pathways (2015, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,vectors)
• Metabolism of a macrophage activated by immune signals (2015, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,NA)
• Metabolism of a cell infected by HCMV (2015, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,NA)
• Cell cycle arrest in senescent cells (2015, Human alphaherpesvirus 1,Measles morbillivirus,Betapolyomavirus macacae,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathway regulation of the differentiations of adipocytes and osteoblasts (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• “Actin Cytoskeleton Signaling” pathway highlighting differentially expressed genes of birds affected with Wooden Breast myopathy (2015, NA)
• Mitochondrial cholesterol trafficking in regulation of macrophage sterol metabolism (2015, NA)
• Brown adipose tissue uncoupling and thermogenesis (2015, Homo sapiens)
• Proposed model for the regulatory role of methenyl-dH4MPT in methylotrophic metabolism in M (2015, NA)
• Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors (2015, NA)
• Periostin is involved in the pathogenic process of eosinophils and Th2-type asthma (2015, NA)
• Key signaling regulation of autophagy in the heart (2015, NA)
• Wnt/Beta-catenin signalling pathway (2015, NA)
• Adipocyte secreted leptin and interleukin-6 has a paracrine effect on nearby breast cancer cells (2015, NA)
• Schematic depiction of functional exosomes secreted from MSC overexpressing CXCR4 for activation of signaling pathways for restoration of LV function after MI (2015, NA)
• Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans (2015, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Lambdavirus lambda)
• Preclinical and Clinical Studies for Sodium Tungstate: Application in Humans (2015, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Lambdavirus lambda)
• Our proposed model for involvement of Tiam1-Rac1 signaling pathway in the activation of Nox2 and downstream stress kinase, leading to mitochondrial dysfunction and retinal capillary cell apoptosis, and the development of diabetic retinopathy (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,PX clade)
• Thiol redox homeostasis in neurodegenerative disease (2015, NA)
• HHLA2 interaction with two receptors to regulate T cell functions (2015, NA)
• Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma (2015, NA)
• Promotion of Bone Morphogenetic Protein Signaling by Tetraspanins and Glycosphingolipids (2015, Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Escherichia coli OP50,Abies alba,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode (2015, Bos taurus,Capra hircus,Ovis aries,Orf virus,Bluetongue virus,Rangifer tarandus,Jaagsiekte sheep retrovirus,Schmallenberg virus,Strongyloides papillosus,Teladorsagia circumcincta,Nematodirus battus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens)
• Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode (2015, Bos taurus,Capra hircus,Ovis aries,Orf virus,Bluetongue virus,Rangifer tarandus,Jaagsiekte sheep retrovirus,Schmallenberg virus,Strongyloides papillosus,Teladorsagia circumcincta,Nematodirus battus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens)
• ERK pathway signaling and outcomes in the M (2015, NA)
• Role of the BM niche in MM pathogenesis (2015, NA)
• House Dust Mite Allergen Regulates Constitutive Apoptosis of Normal and Asthmatic Neutrophils via Toll-Like Receptor 4 (2015, NA)
• Physiological regulation and pharmacological inhibition of the STAT3 signalling pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Signaling pathway of the extrinsic factors, glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) (2015, NA)
• Schematic summary of the therapeutics that have been identified in the inflammatory pathway (2015, Curcuma longa,Zingiber officinale,Silybum marianum,Rheum rhabarbarum,Mus musculus,Rattus norvegicus,Homo sapiens,Cerobasis alpha)
• Glycolysis is the biochemical pathway in which glucose is broken down by cells to make energy (2015, Curcuma longa,Zingiber officinale,Silybum marianum,Rheum rhabarbarum,Mus musculus,Rattus norvegicus,Homo sapiens,Cerobasis alpha)
• Sharing and Specificity of Co-expression Networks across 35 Human Tissues (2015, Homo sapiens,Mus musculus)
• Endogenous and microbial mechanisms to downmodulate and evade DNA-driven innate immune responses (2015, NA)
• Signal transduction pathways activated by DNA to stimulate activation of inflammasomes and the NFKB pathway (2015, NA)
• Signal transduction pathways activated by DNA to stimulate type I IFN expression (2015, NA)
• Network uncovered using IPA (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation (2015, NA)
• Structure of an NDR/LATS Kinase–Mob Complex Reveals a Novel Kinase–Coactivator System and Substrate Docking Mechanism (2015, NA)
• Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease (2015, Homo sapiens)
• Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease (2015, Homo sapiens)
• Coordination of developmental signalling pathways by USP9X (2015, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster)
• Signaling by TGFB family members through the Smad-dependent and Smad-independent pathways: TGFB induces its response by multimerization of TGFB receptor II (TBRII) and TGFB receptor I (TBRI) (2015, NA)
• Downregulation of Notch Signaling Pathway in Late Preterm and Term Placentas from Pregnancies Complicated by Preeclampsia (2015, NA)
• Signaling pathway involved in phosphate-induced myocardial hypertrophy (2015, NA)
• Coagulation and inflammatory response activation during dengue (2015, Dengue virus,Ebola virus,Dengue virus type 2,Dengue virus group,Myeloproliferative leukemia virus,Homo sapiens,Macaca mulatta,Mus musculus)
• Summary of the three-way interaction among AMPK, SIRT1, and eNOS.Notes: AMPK and SIRT1 exhibit a bidirectional interaction in response to cellular energy status and regulate lipid metabolism and inflammatory status (2015, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Generation of lipid mediators (2015, Rattus norvegicus,Homo sapiens)
• Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress (2015, Caenorhabditis elegans,Homo sapiens)
• Proposed bimodal signalling pathways activated by opioid and leading to inhibition and enhancement of P2X3 receptor-mediated current in DRG neurones (2015, Rattus norvegicus,Homo sapiens)
• Members of the BMPR signaling pathway (2015, NA)
• Berberine Inhibits Invasion and Metastasis of Colorectal Cancer Cells via COX-2/PGE2 Mediated JAK2/STAT3 Signaling Pathway (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,herbal medicine,Coptis chinensis,Homo sapiens,Mus musculus,Helicobacter pylori)
• The proposed mechanism of LDH-NP-induced toxicity in A549 cells (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Marmota monax,Chinchilla chinchilla,Adeno-associated virus,Vaccinia virus,adeno-associated virus 2,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,Felis catus,Mandrillus leucophaeus,Columba livia,Streptococcus pneumoniae,NA,NA)
• General scheme, illustrating BDNF-TrkB signaling through three main pathways in the neuronal cell (NC).Notes: PLCG pathway results in activation of neuronal plasticity and long-term memory formation via PKC, TRPC, and transcriptional factor CREB (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Marmota monax,Chinchilla chinchilla,Adeno-associated virus,Vaccinia virus,adeno-associated virus 2,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,Felis catus,Mandrillus leucophaeus,Columba livia,Streptococcus pneumoniae,NA,NA)
• Theoretical model of the negative regulation of the PA signal pathway by myostatin in skeletal muscle (2015, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,S2-like reptarenavirus)
• General procedure for the synthesis and metabolism of glutathione (2015, NA)
• Signaling pathways associated with litter size in boars (2015, NA)
• The role of UV radiation in the modulation of STING-dependent IRF3 activation (2015, NA)
• Integrin-mediated signaling pathway that regulates actin polymerization, actin cytoskeleton remodeling, and microcluster formation (2015, NA)
• Hierarchical Feedback Modules and Reaction Hubs in Cell Signaling Networks (2015, NA)
• Netrin-1 – DCC Signaling Systems and Age-Related Macular Degeneration (2015, NA)
• Analysis of Glioblastoma Patients' Plasma Revealed the Presence of MicroRNAs with a Prognostic Impact on Survival and Those of Viral Origin (2015, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Homo sapiens,unidentified)
• MicroRNA-21 Regulates PI3K/Akt/mTOR Signaling by Targeting TGFBI during Skeletal Muscle Development in Pigs (2015, Homo sapiens,Sus scrofa)
• Neddylation pathways influencing NFKB and HIF-1A (2015, Homo sapiens,Mus musculus)
• The Nodal signaling pathway during establishment of the LR asymmetry in amphioxus (2015, Paracentrotus lividus,Branchiostoma lanceolatum,Deuterostomia,Branchiostoma floridae,Branchiostoma belcheri,Halocynthia roretzi,Branchiostoma belcheri tsingtauense,Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Capra hircus,Homo sapiens)
• Cartoon representing LPA-activated signaling cascades that regulate OHC motility, as suggested by our results and previous studies (in black font), as well as potential mediators and interactions that require confirmation (gray font) (2015, NA)
• Survival signaling vs (2015, NA)
• Angiotensin II, transforming growth factorB, and Smad signaling pathways (2015, NA)
• Schematic of TLR signaling and gene expression following stroke (2015, Human alphaherpesvirus 1,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Candida dubliniensis,Macaca mulatta,Sus scrofa)
• CD44- and CD44v-induced RTK for apoptosis resistance (2015, NA)
• Sustained Interleukin-1B Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids (2015, Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Matthiola incana)
• Phosphorylation pattern of proteins in the Ras1-Cyr1-PKA pathway in C (2015, Candida albicans,Homo sapiens)
• Lysosome pathway (2015, Homo sapiens,Glycine max)
• TLR3/TRIF mainly regulates IL-32-mediated pro-inflammatory cytokine and IFNB secretion through activation of RIP-1 and TRAF family proteins (2015, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human alphaherpesvirus 3,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells (2015, NA)
• Mitochondrial fission induced by the activation of the non-canonical Wnt signaling pathway in dendritic spines (2015, NA)
• Going with the flow: How shear stress signals the emergence of adult hematopoiesis (2015, NA)
• Proposed mechanisms of hair cell regeneration (2015, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Insulin signalling pathway: insulin binds to the insulin receptor leading to its autophosphorylation and recruitment of adaptor molecules such as insulin receptor substrates (IRS 1–6) to engage multiple downstream signalling pathways (2015, NA)
• Green tea modulates the various cell signalling pathways in cancer (2015, Nicotiana tabacum,Olea europaea,Camellia sinensis,Zingiber officinale,Nigella sativa,Phoenix dactylifera,Mus musculus,Rattus norvegicus,Homo sapiens,human papillomavirus 18)
• Role of green tea in cancer prevention through the modulation of genes involved in initiations, promotion, and progression of cancer (2015, Nicotiana tabacum,Olea europaea,Camellia sinensis,Zingiber officinale,Nigella sativa,Phoenix dactylifera,Mus musculus,Rattus norvegicus,Homo sapiens,human papillomavirus 18)
• Upstream analysis focused on transcription factors after Foxa1 knockout in female bladders (2015, NA)
• Most enriched pathways after Foxa1 knockout in female bladders (2015, NA)
• Translational effects of Stat1 (2015, Mus musculus,Homo sapiens)
• HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway (2015, NA)
• Crystalline silica-induced leukotrieneB4-dependent inflammation promotes lung tumor growth (2015, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Candida dubliniensis,Homo sapiens,Bos taurus)
• Cartoon illustration of the physiological roles and therapeutic implications of OCT1, SLC13A5 and ZnT8 in glucose metabolism, lipogenesis and insulin pathway (2015, NA)
• Metabolic pathways associated with 5-HT (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Human immunodeficiency virus 1,Human immunodeficiency virus,Macaca mulatta,Leishmania donovani,Schistosoma mansoni,Mycobacterium tuberculosis,Candida parapsilosis,NA)
• Extra-Nuclear Signaling Pathway Involved in Progesterone-Induced Up-Regulations of p21cip1 and p27kip1 in Male Rat Aortic Smooth Muscle Cells (2015, NA)
• AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver (2015, NA)
• TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway (2015, NA)
• Cellular actions of E2 in POMC neurons (2015, NA)
• Progress in the molecular understanding of central regulation of body weight by estrogens (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Solanum lycopersicum,Equus caballus)
• NOTCH signaling pathway (2015, NA)
• Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation (2015, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Zea mays,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Gallus gallus,Pseudomonas entomophila)
• NRF2-mediated oxidative stress response (2015, Mus musculus,Rattus norvegicus,Gallus gallus,Meleagris gallopavo,Homo sapiens,Spleen focus-forming virus)
• IGFs/PI3K/Akt signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) (2015, Mus musculus,Rattus norvegicus,Gallus gallus,Meleagris gallopavo,Homo sapiens,Spleen focus-forming virus)
• Growth hormone signaling pathway analysis using Ingenuity Molecule Activity Predictor (MAP) (2015, Mus musculus,Rattus norvegicus,Gallus gallus,Meleagris gallopavo,Homo sapiens,Spleen focus-forming virus)
• p22phox confers resistance to cisplatin, by blocking its entry into the nucleus (2015, NA)
• Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells (2015, NA)
• Multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 (2015, NA)
• Cyclin alterations in diverse cancers: outcome and co-amplification network (2015, NA)
• Proteins involved in chromosomal fragility (2015, Hepatitis B virus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Interconnected networks of CEA and TGFB signaling in cancer (2015, NA)
• IPA Network (2015, NA)
• Eukaryotic mechanisms that manage replication– transcription conflicts (2015, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Signaling pathway regulation of ΔNp63 (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Biogenesis of piRNAs: piRNAs are generated from primary and secondary pathways (2015, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Zea mays,Solanum melongena,Oxytricha trifallax,Homo sapiens,Mus musculus,Danio rerio)
• Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus (2015, NA)
• Signaling pathways involved in pluripotency (2015, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• HJV and HFE Play Distinct Roles in Regulating Hepcidin (2015, NA)
• Gallus Gallus retinol metabolic pathway from KEGG (2015, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Capra hircus)
• Schematic intracellular network required for lipid metabolism, Apo B biogenesis, and CM assembly in the enterocyte (2015, Homo sapiens)
• Cancer activates Stat3 in muscle to stimulate loss of muscle mass via two signaling pathways (2015, NA)
• Glycogen stores in astrocytes by insulin and IGF-1 (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation (2015, Mus musculus,Homo sapiens)
• Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells (2015, NA)
• Transcriptional regulation of autophagy in RAS-driven cancers (2015, NA)
• Neuronal Ca2+signalling toolkit (2015, NA)
• Diagrammatic representation of CD40-mediated signalling in human dendritic cells (DCs) in response to Per a 10 stimulation (2015, NA)
• Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes (2015, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Figure shows interaction mechanisms between cancer cells and: (1) Hepatocytes: overexpression of TIMP (Tissue inhibitor of metalloproteinase) is presumed to cause poor prognosis in patients (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Schematic diagram describing the inside-out signaling of S1P (2015, NA)
• Molecular pathways regulating breast cancer stem cells (CSCs) (2015, NA)
• PI3K/AKT/mTOR and the RAS/RAF/MEK/MAPK pathways (2015, NA)
• Image of the MAPK signaling pathway painted by KPP according to the imported list of genes differentially expressed in the prostatic carcinoma as compared to normal prostate (2015, Homo sapiens,NA)
• An incomplete engagement of the TCR pathway differentiates BT-061 from other anti-CD4 mAbs (2015, NA)
• Hypotheses of NALP3 activation via inflammatory pathway (2015, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human papillomavirus,Variola virus,Variola minor virus,Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Cavia porcellus,Bacillus anthracis,Haemophilus influenzae,Homo sapiens,Lareunionomyces loeiensis,Candida albicans,Molva molva,Macaca fascicularis,Pollachius virens,Oryctolagus cuniculus)
• Proposed hypothesis or pathway (2015, NA)
• Pathway visualization (2015, Homo sapiens,Mus musculus)
• Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis (2015, NA)
• Toll-like receptor 4 (TLR4) signalling (2015, NA)
• Coagulation, anticoagulation and fibrinolysis maintain a delicate physiological balance between bleeding and thrombosis (2015, NA)
• Hierarchical stress response following exposure to increasing concentration of AEROSIL® 200 fumed amorphous silica NPs (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Thermococcus gammatolerans)
• Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells (2015, NA)
• Schematic overview of some of the most significant IPA-identified, canonical host response pathways (2015, Schmallenberg virus,unidentified influenza virus,Dengue virus,Sindbis virus,Chikungunya virus,Dengue virus type 2,La Crosse virus,Akabane virus,Ngari virus,Mopeia Lassa virus reassortant 29,Cache Valley virus,Homo sapiens,Mus musculus,Bos taurus,NA,NA)
• Toll-Like Receptor Signaling in Vertebrates: Testing the Integration of Protein, Complex, and Pathway Data in the Protein Ontology Framework (2015, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Pseudomonas aeruginosa,Gallid alphaherpesvirus 1)
• Unigenes involved in the three metabolic pathways (2015, Camellia taliensis,Homo sapiens)
• RNA Sequencing Reveals a Slow to Fast Muscle Fiber Type Transition after Olanzapine Infusion in Rats (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Candida dubliniensis)
• Signaling pathway mediates hepatic fibrogenesis: (A) the TGFB1/SMAD signaling pathway, and (B) TLR4 activated-MyD88/TGFB1/NFKB pathway (2015, NA)
• Schisandrin B inhibits cell growth and induces cellular apoptosis and autophagy in mouse hepatocytes and macrophages: implications for its hepatotoxicity (2015, NA)
• miR-137 targets within Protein Kinase A (PKA) Signaling Pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• miR-137 Intersection Target Network of Neurological Disease (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Fabric of signaling cascades can be activated by astrocyte Gq-GPCRs (2015, NA)
• HPV carcinogenesis (2015, NA)
• Role of the ER lipid signaling pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,bacterium C-10,NA,NA)
• ER-mitochondrion tethering (2015, Mus musculus,Rattus norvegicus,Homo sapiens,bacterium C-10,NA,NA)
• GAi1/3-mediated activation of TLR4 in response to LPS (2015, Mus musculus,Homo sapiens)
• Shared metabolic pathways among glycolysis, the OPPP, and the Calvin cycle, as well as the circadian patterns of genes for their enzymatic steps (2015, Synechococcus elongatus)
• KEGG pathway map for complement and coagulation pathway (2015, NA)
• KEGG pathway map for TGFB and MAPK signaling pathways (2015, NA)
• Relationship between the genes in each module from the GBM dataset (2015, NA)
• Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors (2015, NA)
• Immunological parameters as a new lead in the diagnosis of ovarian cancer (2015, Homo sapiens)
• Metabolic network of CcsR-dependent targets and influence on cell regulatory networks (2015, Cereibacter sphaeroides,phototrophic bacterium)
• Role of antagonists in Wnt signaling pathway (2015, NA)
• Canonical and noncanonical Wnt signaling pathways (2015, NA)
• Loregic: A Method to Characterize the Cooperative Logic of Regulatory Factors (2015, NA)
• DIANA miRPath analysis of target genes for miRNAs downregulated in AD blood (2015, NA)
• DIANA miRPath analysis of target genes for miRNAs upregulated in AD blood (2015, NA)
• PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through Beta-Catenin Signaling (2015, NA)
• Insulin binding causes activation of the insulin receptor (IR), which phosphorylates different substrate adaptors such as the insulin receptor substrate (IRS) (2015, Solanum lycopersicum,Theobroma cacao,Ipomoea batatas,Fagopyrum esculentum,Vaccinium myrtillus,Vaccinium angustifolium,Euonymus alatus,Cassia fistula,Gymnanthemum amygdalinum,Tetracera scandens,Schwenckia americana,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta,Corynephage beta)
• Hm-MyD88 and Hm-SARM: Two key regulators of the neuroimmune system and neural repair in the medicinal leech (2015, Drosophila melanogaster,Caenorhabditis elegans,Branchiostoma lanceolatum,Penaeus vannamei,Patinopecten sp.,Mytilus galloprovincialis,Scylla serrata,Suberites domuncula,Hirudo medicinalis,Scylla paramamosain,Lophotrochozoa,Carcinoscorpius rotundicauda,Escherichia coli,Gallus gallus,Danio rerio,Salmonella enterica,Aeromonas hydrophila,Xenopus tropicalis,Epinephelus coioides,Dermacoccus nishinomiyaensis,Vesicular stomatitis virus,West Nile virus,Porcine reproductive and respiratory syndrome virus,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Saccharomyces cerevisiae)
• Functions of Klotho (2015, NA)
• PRC2-independent transcriptional activation by EZH2 in cancer (2015, NA)
• Canonical and noncanonical Sap-induced inflammasome activation (2015, NA)
• Activation of the MAPK pathway in thyroid cancer (2015, NA)
• Putative KF inhibition pathway in macrophage-mediated inflammatory signaling events (2015, NA)
• Conceptual model describing the response of Arthrospira sp (2015, Arthrospira sp.,Homo sapiens)
• Unraveling the Molecular Signatures of Oxidative Phosphorylation to Cope with the Nutritionally Changing Metabolic Capabilities of Liver and Muscle Tissues in Farmed Fish (2015, NA)
• Role of mTOR in Treg differentiation and function (2015, NA)
• MTOR signaling and metabolic regulation (2015, NA)
• Epidermal Wound Healing in the Nematode Caenorhabditis elegans (2015, Caenorhabditis elegans,Homo sapiens)
• Pathway on the left is that of an active cell (2015, NA)
• Comparison between simulations and gene expression data (2015, Escherichia coli,Bacillus subtilis,Escherichia coli K-12,Clostridium acetobutylicum,Zymomonas mobilis,Homo sapiens)
• Metabolic loops increase pathway multiplicity (2015, Escherichia coli,Bacillus subtilis,Escherichia coli K-12,Clostridium acetobutylicum,Zymomonas mobilis,Homo sapiens)
• Schematic model of novel inhibitors in Fas-associated death domain-Procaspase 8 interaction and Caspase 3 activation via Caspase 8 (2015, Homo sapiens)
• Translocations affecting the NFKB activation pathway (2015, NA)
• Proposed model of signaling pathways activated in primary NHP microglia in response to B (2015, NA)
• Proposed model of ATM activation downstream of TGFB signaling in the context of renal biology (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles (2015, NA)
• Casein kinase 1A–dependent feedback loop controls autophagy in RAS-driven cancers (2015, NA)
• Reduced Tyk2 gene expression in Beta-cells due to natural mutation determines susceptibility to virus-induced diabetes (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Cavia porcellus,Encephalomyocarditis virus,Mengo virus,Kilham rat virus,Homo sapiens)
• E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling (2015, Mus musculus,Peromyscus sejugis,Homo sapiens,Bos taurus,vectors)
• Representation of the proposed mechanism of action for CM-hfMSCs on insulin-like growth factor (IGF)-expressing cells (2015, Homo sapiens)
• Canonical pathways and phenotypic interpretation derived from the microarray analysis (2015, NA)
• MLK3 Phophorylates AMPK Independently of LKB1 (2015, NA)
• Exploring Triacylglycerol Biosynthetic Pathway in Developing Seeds of Chia (Salvia hispanica L.): A Transcriptomic Approach (2015, NA)
• Extrinsic and intrinsic pathways of apoptosis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus)
• MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction (2015, NA)
• MiRNA and TF co-regulatory network analysis for the pathology and recurrence of myocardial infarction (2015, NA)
• An illustration of the coupling between the circadian neurons and PTTH-secreting neurons that control photoperiodism in A (2015, Locusta migratoria,Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Tribolium castaneum,Ciona intestinalis,Branchiostoma lanceolatum,Acyrthosiphon pisum,Ixodes scapularis,Culex quinquefasciatus,Tetranychus urticae,Strongylocentrotus purpuratus,Pleocyemata sp.,Nematostella vectensis,Clonorchis sinensis,Aplysia californica,Branchiostoma floridae,Daphnia pulex,Hydra vulgaris,Amphimedon queenslandica,Procambarus clarkii,Trichoplax adhaerens,Periplaneta americana,Ecdysozoa,Echinococcus granulosus,Saccoglossus kowalevskii,Pediculus humanus corporis,Ancylostoma ceylanicum,Antheraea pernyi,Gryllus bimaculatus,Zootermopsis nevadensis,Capitella teleta,Lottia gigantea,Cancer pagurus,Helobdella robusta,Galendromus occidentalis,Nephrops norvegicus,Acheta domesticus,Neohelice granulata,Allodiopsis domestica,Dianemobius nigrofasciatus,Oziotelphusa senex,Gallus gallus,Danio rerio,Xenopus laevis,Dipnomorpha,Xenopus tropicalis,catfish,Vertebrata,Callorhinchus milii,Python bivittatus,Lampetra ayresii,Saccharomyces cerevisiae,Oryza sativa,Embryophyta,PX clade,Malus domestica,Cucumis sativus,Glycyrrhiza uralensis,Mus musculus,Rattus norvegicus,Ovis aries,Synechocystis sp.,Panthera tigris,Anabaena sp.,Homo sapiens,NA)
• Nuclear distribution of the PI3K pathway (2015, NA)
• Ligand recognition and second-messenger signaling at PTHR1 (2015, NA)
• Regulation of genes in IL1/TLR signaling pathways (2015, Escherichia coli,Helicobacter pylori,Haemophilus influenzae,Haemophilus influenzae 3655,Mus musculus,Rattus norvegicus,Chinchilla chinchilla,Homo sapiens,Bos taurus,Diaporthe sclerotioides,synthetic gene)
• Regulation of genes in the JAK/STAT signaling pathway (2015, Escherichia coli,Helicobacter pylori,Haemophilus influenzae,Haemophilus influenzae 3655,Mus musculus,Rattus norvegicus,Chinchilla chinchilla,Homo sapiens,Bos taurus,Diaporthe sclerotioides,synthetic gene)
• ROS rheostat of hematopoietic stem cell (HSC) maintenance (2015, NA)
• Findings from our laboratory using an animal model of the autoimmune disease, RA, reveal disease-related changes in B2-AR signaling that are dependent upon the lymphoid tissue examined (2015, NA)
• Presence of a B2-AR ligand during lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA)-induced macrophage activation causes reduced or increased production of TNFA, IL-12 and nitric oxide respectively (2015, NA)
• Hypothetical model for shifting B2-AR signaling from the canonical pathway towards the non-canonical pathway in immune cells is illustrated (2015, NA)
• Canonical B2-adrenergic receptor (AR) signaling pathway is illustrated here (2015, NA)
• Chronologically aging culture of yeast cells progresses through at least seven consecutive “checkpoints”, each of which defines yeast longevity (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Listeria monocytogenes)
• FGF signaling pathways (2015, NA)
• FGF and FGFR families (2015, NA)
• LBW affects cardiac RAS but not cardiac autophagy (2015, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Ovis aries,Cavia porcellus,Homo sapiens,Gallus gallus)
• Network representations of the differentially expressed genes presented in pathway analysis (2015, Homo sapiens,Mus musculus,NA)
• Proposed model for the involvement of TRIP in the TNF-induced inflammatory response (2015, Homo sapiens)
• Suggested mechanism by which cAMP signaling reduces SIRT6 expression in lung cancer cells, resulting in augmented apoptosis (2015, Homo sapiens)
• Comparing CGN death induced by NSC23766 and ToxB (2015, Rattus norvegicus,Clostridioides difficile,Homo sapiens)
• Differentially expressed genes related to BMP signalling at day 0 to 3 of arthritis in comparison to non-induced controls (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Diaporthe sclerotioides)
• H3K56 acetylation prevents genomic instability by affecting Ctf4 function (2015, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Diagram of potential APOE4 -induced decrease in synapse-related proteins and disruption of NMDAR-mediated signaling, resulting in impaired learning and memory (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• DNA damage pathways and how CHK1-, WEE1-, or CDK1 inhibitors can synergize with cytarabine to increase its DNA damaging efficacy in AML (2015, Homo sapiens,Mus musculus)
• Biochemical pathways for the synthesis of sucrose, trehalose (OtsAB pathway, used only by Crocosphaera watsonii in cyanobacteria), glucosylglycerol (GG) and glucosylglycerate (GGA) (2015, NA)
• Architecture of a signaling network that accounts for the relation between the effects of insulin, ATIC, and ATP level (2015, NA)
• Construction of the Golgi/endosome network (GEN) and of the IR subnetwork (IRGEN) (2015, NA)
• Representative protein-protein interaction networks of key pathways and proteins involved in sperm functions (2015, NA)
• Major interconnected signaling pathways that regulate EMT (2015, NA)
• Schematic showing the TGFB/LIF- mediated tumor suppressive role in melanoma (2015, NA)
• Conceptual model of general lifestyle factors, salient CHD pathogenetic pathways and CHD hallmarks (2015, Porphyromonas gingivalis,Homo sapiens)
• CD44 acts as a co-receptor for several cell surface receptors including RTKs, G-protein coupled receptors, and LRP6 (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Time-resolved metabolic reprograming during pro-inflammatory macrophage polarization (2015, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Ovis aries,Homo sapiens,Saccharomyces cerevisiae,NA)
• Plant phytochemicals achieve hormesis through multifocal pathway inhibition (2015, NA)
• Activators of ERK5 Pathway (2015, NA)
• Role of Notch Signalling in CD34+ Chronic Myeloid Leukaemia Cells: Cross-Talk between Notch and BCR-ABL (2015, NA)
• Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells (2015, NA)
• Significantly affected canonical pathway “interferon signaling”, as determined by IPA® analysis (2015, Human immunodeficiency virus 1,Hepatitis B virus,unidentified influenza virus,Reovirus sp.,Avian orthoreovirus,Mammalian orthoreovirus 3,Mammalian orthoreovirus 3 Dearing,Infectious hematopoietic necrosis virus,Mammalian orthoreovirus 1 Lang,Mammalian orthoreovirus 4 Ndelle,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Armoracia rusticana,Matthiola incana,Butea monosperma,Mus musculus,Rattus norvegicus,Escherichia coli,Danio rerio,Salmo salar,Renibacterium salmoninarum,Homo sapiens)
• Schematic model of the anticancer mechanism of physalin B in HCT116 cells (2015, Homo sapiens)
• BCL6 targets Tfh genes mainly involved in T cell signaling, differentiation, and migration pathways to drive the GC Tfh phenotype (2015, NA)
• Reperfusion signalling pathways underlying ischaemic conditioning (2015, NA)
• Intracellular signal paths coupled to the opioid receptors and implicated in cardiac stress signalling and cardioprotection (2015, Homo sapiens)
• Extracellular signalling molecules in the ischaemic/reperfused heart – druggable and translatable for cardioprotection? (2015, NA)
• Simplified schematic presentation of the cytosolic signalling pathways that converge to prevent mitochondrial permeability transition pore (MPTP) opening in cardioprotection (2015, NA)
• The identified components of postconditioning signalling in the myocardium (2015, NA)
• Coincidence detection during classical conditioningThe signalling pathways shown are simplified to focus on the coincidence detection function of the receptors described here (2015, NA)
• Mathematically modelled pathway from SPGN excitation to smooth muscle cell activation (2015, Canis lupus familiaris,Sus scrofa,Homo sapiens,Rattus norvegicus)
• Signaling pathway map (2015, NA)
• The mechanism of the switch off in Shh canonical signaling during spinal cord development (2015, NA)
• The phosphoproteomics data (2015, NA)
• Simplified model depicting (a) Novel positive feedback loop between TGF-Beta-SMAD3 and KLF17 in cancer cells (2015, NA)
• Cytotoxic agents impact the Bcl-2 rheostat (2015, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach (2015, NA)
• Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFA and ROS production (2015, NA)
• Interaction between microRNAs and factors involved in malignant transformation caused by HPV E6 and E7 expression in cervical cancer cell (2015, Human papillomavirus,Human papillomavirus type 16,Alphapapillomavirus 7,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Gallus gallus)
• Innate immune evasion of hepatitis C virus infection (2015, NA)
• Nucleotide sugar UDP-GlcNAc resides at the nexus of protein and lipid glycosylation (2015, NA)
• APP protein-protein interaction networks (2015, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Panthera tigris,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Paradoxical roles of autophagy induced by the tumor microenvironment during different stages of tumor development (2015, NA)
• PI3K-Akt-mTOR signaling pathway (2015, Homo sapiens)
• IFN-induced signaling through the JAK-STAT pathway (2015, NA)
• Regulatory mechanisms of GAPDH by insulin and hypoxia (2015, NA)
• Transcriptome Analysis and Its Application in Identifying Genes Associated with Fruiting Body Development in Basidiomycete Hypsizygus marmoreus (2015, NA)
• Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation (2015, Larimichthys crocea,Homo sapiens)
• Scavenger Receptor SREC-I Mediated Entry of TLR4 into Lipid Microdomains and Triggered Inflammatory Cytokine Release in RAW 264.7 Cells upon LPS Activation (2015, Escherichia coli,Escherichia coli K-12,Clostridioides difficile,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Candida dubliniensis,NA)
• Serum starvation induces changes to cellular metabolism and chromatin remodeling proteins (2015, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Bos taurus,Caenorhabditis elegans)
• Intracellular fatty acid metabolism (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Candida dubliniensis,Bikinia letestui,Homo sapiens,Canis lupus familiaris,Betapolyomavirus macacae)
• The major pathways involved in the molecular mechanisms of cancer (2015, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,Danio rerio,Hepatitis B virus,NA)
• Metformin action to inhibit cancer (2015, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples,Bikinia letestui)
• Foxp3-biding genes in ‘pathway in cancer’ (2015, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Ingenuity pathway analysis (IPA) of differentially expressed proteins (2015, NA)
• Major functions, interrelationships among thiol and non-thiol compounds, and their coordination with other defense system components in metal(loid)-exposed plants (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Triticum aestivum,Hordeum vulgare,PX clade,Malus domestica,Vitis vinifera,Cucumis sativus,Brassica napus,Sorghum bicolor,Magnoliopsida,Helianthus annuus,Spinacia oleracea,Chlamydomonas reinhardtii,Brassica oleracea,Allium sativum,Pyrus communis,Phaseolus vulgaris,Raphanus sativus,Saccharum officinarum,Beta vulgaris,Citrus limon,Brassica juncea,Vigna radiata,Phaeodactylum tricornutum,Prunus domestica,Triticum turgidum subsp. durum,Nitzschia alba,Marchantiophyta,Chlorella vulgaris,Aspergillus sp.,Bryophyta,Cajanus cajan,Brassica rapa subsp. oleifera,Colocasia esculenta,Vigna mungo,Fucus vesiculosus,Populus tremula x Populus alba,Malus hupehensis,Secale cereale,Ceratophyllum demersum,Brassica carinata,Noccaea caerulescens,Silene vulgaris,Melilotus albus,Picea rubens,Thlaspi arvense,Chlamydomonas moewusii,Arabidopsis halleri,Sedum alfredii,Stichococcus bacillaris,Tamarix androssowii,Atriplex portulacoides,Avicennia germinans,Elodea canadensis,Pteris vittata,Noccaea caerulescens subsp. caerulescens,Micrasterias denticulata,Noccaea goesingensis,Hirschfeldia incana,Thlaspi oxyceras,Cicer microphyllum,Odontarrhena lesbiaca,Alyssum montanum,Masmenia rosularis,Holcus lanatus,Salvinia minima,Desmodesmus armatus,Hydrocharis dubia,Stigeoclonium tenue,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Caenorhabditis elegans,Equus caballus,Merlangius merlangus)
• Proposed model of novel roles of AQP3 and AQP5 in tumor biology (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model of novel role of AQP1 in tumor biology (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways involved in thyroid carcinogenesis and tumor progression (2015, NA)
• Pathway as a Pharmacological Target for Herbal Medicines: An Investigation from Reduning Injection (2015, Armoracia rusticana,herbal medicine,Cinnamomum verum,Gardenia jasminoides,Lonicera japonica,Cinnamomum osmophloeum,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli)
• Essential role for autophagy in life span extension (2015, NA)
• Autophagy in cellular metabolism and cancer (2015, NA)
• Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase (2015, NA)
• Biological activities of TACI (2015, unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Mus musculus,Citrobacter rodentium)
• Transcript abundance of genes related to central metabolic pathways under different conditions in K (2015, Kluyveromyces marxianus,Homo sapiens)
• Important ECM molecules and ECM receptors involved in cancer cell invasion (2015, NA)
• Functions of CDK4/Cyclin D and CDK5/p25 (2015, Homo sapiens)
• Biochemical pathway proposed to regulate sperm capacitation and hyperactivation (2015, NA)
• ROCK and Rho (2015, NA)
• Pharmacological targets and signaling cascades proposed to be important in mediating synaptic plasticity underlying extinction (2015, Homo sapiens)
• Specific Medicinal Plant Polysaccharides Effectively Enhance the Potency of a DC-Based Vaccine against Mouse Mammary Tumor Metastasis (2015, NA)
• Impact of Host Diet on Wolbachia Titer in Drosophila (2015, Escherichia coli,Drosophila melanogaster,Bacillus subtilis,Bacillus subtilis At2,Aedes aegypti,Francisella tularensis,Acyrthosiphon pisum,Glossina morsitans,Drosophila simulans,Wolbachia endosymbiont of Drosophila melanogaster,Hydra viridissima,Candidatus Uzinura,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Capra hircus,Zea mays,Matthiola incana,Homo sapiens,Mus musculus,Dengue virus,Lactococcus phage P001)
• Pik3ip1 Modulates Cardiac Hypertrophy by Inhibiting PI3K Pathway (2015, NA)
• Host Glycan Sugar-Specific Pathways in Streptococcus pneumonia: Galactose as a Key Sugar in Colonisation and Infection (2015, NA)
• Simplistic overview of the top two mutation-enriched transduction signaling pathways in ATC as according to the Genomatix Pathway System (2015, NA)
• As yet unknown side of DC secretion post-TLR activation, and trafficking molecules currently identified in DC function (2015, NA)
• Involvement of K Ca3.1 in the TGF/Smad 2/3 signalling pathway (2015, NA)
• Fate of plasmids and their expressed antigens after electroporation (A); The Fas/FasL signaling pathway and some of the key molecules involved (B) (2015, Human immunodeficiency virus 1,Hepatitis B virus,H1N1 subtype,Simian immunodeficiency virus,HIV-1 group M,Human adenovirus 35,Mus musculus,Rattus norvegicus,Cricetulus migratorius,Homo sapiens,Oryctolagus cuniculus,Capra hircus,Macaca mulatta,Armoracia rusticana,Simian-Human immunodeficiency virus,NA,NA)
• Telomerase Inhibition Decreases Alpha-Fetoprotein Expression and Secretion by Hepatocellular Carcinoma Cell Lines: In Vitro and In Vivo Study (2015, NA)
• Schematic presentation of chloroplast proteins affected in executer mutants and WT plants after light treatment compared to WT plants under normal or growth light conditions, as shown in Table 3 (2015, Arabidopsis thaliana,Nicotiana tabacum,Embryophyta,Solanum tuberosum,Chlamydomonas reinhardtii,Hedera canariensis,Homo sapiens,Bos taurus,Pseudomonas syringae,Perca fluviatilis)
• S-Nitrosylated proteins involved in photosynthesis (2015, Arabidopsis thaliana)
• Biological roles of sulphate and pathways of sulphate homeostasis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Sus scrofa,Malus domestica)
• Possible transforming pathway (2015, Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Mouse mammary tumor virus,Bacillus anthracis)
• Regulatory pathways and candidate genes associated with fatty acid synthesis in B (2015, Brassica napus)
• Gene interaction pathway (2015, Brassica napus)
• Pathway for a network related to cell to cell signaling process in the anaplastic thyroid carcinoma (2015, NA)
• Relevant crosstalk of altered signaling pathways involved in cell death for PTC and ATC (2015, NA)
• Schematic overview of autophagy machinery and its regulation by sphingolipids (2015, NA)
• Key events in the apoptotic pathway and regulation of apoptosis by sphingolipids (2015, NA)
• Sphingolipid metabolism (2015, Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Semliki Forest virus,NA)
• Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis (2015, Ixodes scapularis,Anaplasma phagocytophilum,Homo sapiens)
• Gallic Acid Induces Necroptosis via TNF–A Signaling Pathway in Activated Hepatic Stellate Cells (2015, NA)
• Obesity genetics in mouse and human: back and forth, and back again (2015, NA)
• Discordant and concordant gene expression in the PI3K-Akt-mTORC1 signaling cascade (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Gallus gallus,Canis lupus familiaris)
• The modulation of downstream signaling pathways of the brain derived neurotrophic factors (BDNF) by glucocorticoids (GCs) (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Corynebacterium phage gamma)
• Interplay between glucose and leptin signaling determines the strength of GABAergic synapses at POMC neurons (2015, NA)
• Proposed signaling pathway involved in the effect of U-II on L-type Ca2+ channels (2015, NA)
• Explanation for the role of CaMKII involved in the 20E pathways (2015, Helicoverpa armigera)
• Summary illustration (2015, NA)
• Macrophage Gene Expression Associated with Remodeling of the Prepartum Rat Cervix: Microarray and Pathway Analyses (2015, NA)
• Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners (2015, NA)
• Metabolic pathway of 5ALA (2015, Homo sapiens,Dipturus trachyderma)
• Schematic diagram for the clinical regulatory pathway of probiotics (2015, NA)
• Towards Anatomic Scale Agent-Based Modeling with a Massively Parallel Spatially Explicit General-Purpose Model of Enteric Tissue (SEGMEnT_HPC) (2015, Homo sapiens)
• Mucosal barrier integrity and inflammation (2015, Candida albicans,Aspergillus fumigatus,Aspergillus niger,Lotus japonicus,Hevea brasiliensis,Candida albicans 28H,Escherichia coli,Danio rerio,Xenopus laevis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pneumoniae,teleost fish,Oryzias latipes,Helicobacter pylori SS1,Lepisosteus oculatus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens,Bos taurus)
• Network of HMGA regulatory mechanisms in human carcinomas (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryza sativa)
• Feedback mechanisms mediated by the extracellular cAMP–adenosine cascade (2015, NA)
• Diagram depicting DA metabolic pathways (2015, NA)
• Three core signaling pathways altered in malignant gliomas (2015, NA)
• Top Kegg pathways enriched with aDMCs identified by the FatiGO analysis (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Function of NMDA receptors and protein kinase C signaling in the JH signaling pathway for male production of D (2015, NA)
• E2-induced signal transduction pathways in the uterine epithelium leading to DNA and protein synthesis (2015, NA)
• Developmental Exposure to Estrogen Alters Differentiation and Epigenetic Programming in a Human Fetal Prostate Xenograft Model (2015, NA)
• Vitamin D Receptor Cdx-2 Polymorphism and Premenopausal Breast Cancer Risk in Southern Pakistani Patients (2015, NA)
• Pathways involved to block cell cycle progression (2015, NA)
• Schematic depiction of sonic hedgehog (SHH) synthesis, secretion, and signaling (2015, NA)
• Signalling mechanisms regulating phenotypic changes in breast cancer cells (2015, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Calcium signaling pathway in old nitrate treated aorta (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Integrating Clinical Indexes into Four-Diagnostic Information Contributes to the Traditional Chinese Medicine (TCM) Syndrome Diagnosis of Chronic Hepatitis B (2015, NA)
• Signaling pathway associated with CD37 ligation by SMIP-016 (2015, NA)
• Synthesis and mechanisms of gaseous neurotransmitters in the relaxation of penile or other vascular tissues (2015, NA)
• NO signalling and metabolic syndrome-related pathways (2015, NA)
• Oleic Acid Metabolism via a Conserved Cytochrome P450 System-Mediated omega-Hydroxylation in the Bark Beetle-Associated Fungus Grosmannia clavigera (2015, Grosmannia clavigera,Saccharomyces cerevisiae,Candida albicans,Aspergillus nidulans,Pyricularia oryzae,Fusarium verticillioides,Candida tropicalis,Parastagonospora nodorum,Clavispora lusitaniae,Curvularia lunata,Pinus contorta,Ophiostoma piceae,Candida albicans 23K,Pseudozyma flocculosa,Escherichia coli,Escherichia coli 53A,Homo sapiens,Oryctolagus cuniculus,Dendroctonus ponderosae,NA)
• Interleukin-1B and its interacting proteins in Alzheimer’s disease (2015, NA)
• Kyoto Encyclopedia of Genes and Genomes pathway created using ‘Alzheimer’ as a key word (2015, NA)
• ER stress activates p38 and JNK through an IRE1/TRAF2/ASK1-mediated signaling pathway (2015, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,prion,Sar)
• Regulators of HR repair as potential therapeutic targets (2015, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus)
• DNA double strand break (DSBs) repair (2015, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus)
• Pathway for estrogen-induced ASC1 ufmylation for ERA transactivation (2015, NA)
• TPA-induced survival signaling (2015, NA)
• Genomic signaling pathways for PR action (2015, NA)
• Epidermal growth factor receptor pathway (2015, NA)
• Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 (2015, Homo sapiens,Mus musculus,Bos taurus,Human adenovirus 5)
• Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53 (2015, Homo sapiens,Mus musculus,Bos taurus,Human adenovirus 5)
• Molecular Interaction of a Kinase Inhibitor Midostaurin with Anticancer Drug Targets, S100A8 and EGFR: Transcriptional Profiling and Molecular Docking Study for Kidney Cancer Therapeutics (2015, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,Canis lupus familiaris,NA)
• The signaling pathway through which MIF increases vascular permeability (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Armoracia rusticana,Cavia porcellus,Dengue virus,Vibrio cholerae,Ebola virus sp.,Homo sapiens)
• Interrelation of ROS and inflammatory cytokines in neurodegeneration (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• The major TNFR1-mediated signaling pathways (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• HA precursors biosynthesis and main HAS2 regulation in SMCs (2015, Mus musculus,Rattus norvegicus,Streptococcus pyogenes,Heterocephalus glaber,Pasteurella multocida,Streptococcus dysgalactiae subsp. equisimilis,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis)
• Proposed model for the integration of NFAT and NFKB signalling pathwaysSwollen AF conidia are taken up by macrophages (2015, Aspergillus fumigatus,Homo sapiens)
• Activation of the DNA damage response (DDR) after DNA double-strand breaks (DSB) induction in young and old cells (2015, NA)
• MiRNA targeted upregulated genes of Rho GTPase signaling (2015, NA)
• MiRNA targeted signaling pathways in four different important cells including plaque macrophage, platelet, monocyte and endothelial cell (2015, NA)
• MicroRNAs Are Part of the Regulatory Network that Controls EGF Induced Apoptosis, Including Elements of the JAK/STAT Pathway, in A431 Cells (2015, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster)
• TLR and NLR pathways (2015, Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Homo sapiens,Mus musculus,Candida albicans)
• The molecular regulation of autophagy (2015, NA)
• CD9 signaling (2015, NA)
• The immune response against Leishmania mexicana and the role of IL-10 (2015, NA)
• Potential canonical WNT signaling pathway- Resting state (a): SFRP4 binds free WNT molecules in the extracellular space and DKK binds the LRP co-receptor (2015, Homo sapiens)
• Endocrine resistance in breast cancer cells (2015, NA)
• Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy (2015, NA)
• IPA-inferred Sertoli cell – Sertoli cell junction signalling pathway (2015, NA)
• Anatomical and pharmacological properties of the 5-HT2A receptors in the brain (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Felis catus)
• Ruthenium Polypyridyl Complex Inhibits Growth and Metastasis of Breast Cancer Cells by Suppressing FAK signaling with Enhancement of TRAIL-induced Apoptosis (2015, NA)
• PI3K pathway (2015, NA)
• Underlying link between Alzheimer’s disease and type 2 diabetes mellitus.Notes: Insulin resistance reduces the degradation of AB by IDE, and makes the combination of insulin and insulin receptor impaired (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Bisphenol-A Affects Male Fertility via Fertility-related Proteins in Spermatozoa (2015, NA)
• T-cell activation pathway regulating six key activation genes (2015, NA)
• Regulation of ODA activity (2015, Homo sapiens)
• Proposed pathway of prolonged EtOH activation of PP1 resulting in decreased stimulated cilia beating (2015, Mus musculus,Homo sapiens)
• Lipid metabolism, molecular transport, small molecule biochemistry (2015, Bos taurus,Sus scrofa,Matthiola incana,Iris germanica,Homo sapiens,Rattus norvegicus,Escherichia coli,Gallus gallus)
• Cell-cell signaling and interaction, molecular transport, small molecular biochemistry (2015, Bos taurus,Sus scrofa,Matthiola incana,Iris germanica,Homo sapiens,Rattus norvegicus,Escherichia coli,Gallus gallus)
• Cardiovascular disease, lipid metabolism, molecular transport (2015, Bos taurus,Sus scrofa,Matthiola incana,Iris germanica,Homo sapiens,Rattus norvegicus,Escherichia coli,Gallus gallus)
• Helicobacter pylori bacteria alter the p53 stress response via Erk-HDM2 pathway (2015, Helicobacter pylori,Homo sapiens)
• Androgen receptors beyond prostate cancer: an old marker as a new target (2015, NA)
• Androgen receptors beyond prostate cancer: an old marker as a new target (2015, NA)
• MiR-199a-5p in smooth muscle differentiation and hypertrophy (2015, NA)
• Reciprocal regulation of AMPK and PLD (2015, NA)
• Proposed model for the role of ESCRTs in regulating GPCR-promoted Akt activation (2015, NA)
• Plasma treatment abolish siRNA-induced knockdown of NRF2 (2015, Homo sapiens)
• Bistability in a Metabolic Network Underpins the De Novo Evolution of Colony Switching in Pseudomonas fluorescens (2015, NA)
• Identification of microRNAs and their target genes in Alport syndrome using deep sequencing of iPSCs samples (2015, Homo sapiens)
• One-carbon metabolism and methotrexateMTX enters the cell via the reduced folate carrier (RFC) by using an endocytic pathway activated by a folate receptor (FOLR [A, ƴ]) (a) (; ) (2015, NA)
• Metabolic network for flux analysis (2015, NA)
• Pathways mapping of fussed network proteins (2015, NA)
• Molecular interaction and biological pathways networks of regulated proteins in liver tumours of EGF transgenic mice (2015, NA)
• Chaperone balance (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Mitochondria are the main source of free radicals in neurodegenerative diseases, which is particularly true in the Alzheimer brain (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Cinnamon-mediated protection of dopaminergic neurons (2015, NA)
• Schematic diagram of HIF proteins (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Helicobacter pylori,Panax ginseng)
• Caspase function in tissue regeneration and tumor cell proliferation (2015, NA)
• Canonical and non-canonical Wnt signaling pathways (2015, NA)
• Active and inactive Wnt/Beta-catenin signaling (2015, NA)
• Schematic model for the integration of TORC2 into the Pkc1-Mpk1 MAP kinase (MAPK) cascade in S (2015, NA)
• Change in TNFR1 signaling pathway in 3 h, 12 h, and 24 h groups after cerebral ischemia-reperfusion injury (2015, Mus musculus,Rattus norvegicus,Homo sapiens,prion)
• Multi-step and artificial two-step pathways (2015, Saccharomyces cerevisiae,Escherichia coli,Glycine max,Olea europaea,Escherichia coli DH5alpha,Komagataella pastoris,Escherichia coli BL21DE3,Nostoc punctiforme PCC 73102,Thermomyces lanuginosus,Jeotgalicoccus sp.,Homo sapiens)
• Changes in Protein Expression in Two Cholangiocarcinoma Cell Lines Undergoing Formation of Multicellular Tumor Spheroids In Vitro (2015, Bos taurus,Sus scrofa,Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Human immunodeficiency virus 1,NA)
• PRR and signaling pathways that lead to differentiation of antifungal T-helper cells (2015, Homo sapiens,Mus musculus)
• RNA toxicity leads to activation of NFKB pathway (2015, Homo sapiens,Mus musculus)
• Polycomb and trithorax proteins regulate chromatin structure and gene expression (2015, NA)
• miR-4689 regulates EGFR signaling pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,clinical samples,NA)
• Life cycle of ORF57 protein (2015, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human alphaherpesvirus 3,Saimiriine gammaherpesvirus 2,Deltapapillomavirus 4,Simian sarcoma-associated virus,Woolly monkey sarcoma virus,Homo sapiens,Bos taurus,Bacteriophage sp.,NA)
• SIRT1 in synaptic plasticity (2015, NA)
• Synthesis and metabolism of glutathione and its regulation by the circadian system (2015, NA)
• DNA damage response pathways involved in the G2 exit program leading to senescence (2015, NA)
• Molecular pathways involved in irreversible G1 arrest proceeding senescence (2015, NA)
• Regulatory pathways downstream of BMP, Fgf18, CNP, Ihh or PTHrP signaling control chondrocyte proliferation and hypertrophy (2015, NA)
• Different combinations of transcription factors drive tissue-specific gene expression in immature versus hypertrophic chondrocytes (2015, NA)
• Multiple signaling pathways regulate the expression and activity of Sox9 during chondrogenesis (2015, NA)
• Comparison of models of Wnt signaling (2015, Homo sapiens)
• TRAIL-receptor mediated signalling pathways (2015, NA)
• Co-regulation analysis among 6 potential internal control genes (ICGs) (2015, NA)
• Sphingolipids metabolo-genomic pathway patterns associated with chronic obstructive pulmonary disease (COPD) subphenotypes (2015, NA)
• Schematic depiction of PTEN functions in nucleus and cytosol with regard to its posttranslational modifications (2015, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• EtOH and INK128 impact on the mTOR pathway and cellular response (2015, NA)
• Immunologic manifestations of autophagy (2015, Mycobacterium tuberculosis)
• Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer (2015, Homo sapiens)
• Mining Host-Pathogen Protein Interactions to Characterize Burkholderia mallei Infectivity Mechanisms (2015, Burkholderia mallei,Homo sapiens)
• Downstream signaling of BAFF-R (2015, NA)
• Sphingolipid metabolic network (2015, Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Ebola virus)
• P2Y13 receptors couple to the survival promoting pathway of GSK3 signaling inhibition in granule neurons (2015, NA)
• Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway (2015, NA)
• The mechanism of action of P2X receptors in cardiac myocytes (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Oxidative Krebs cycle (2015, Escherichia coli IS1,Escherichia coli 14A,Escherichia coli O2H1,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Armoracia rusticana)
• Calcium signaling and canonical pathways were constructed using Ingenuity Pathway Analyses System (2015, NA)
• Gibberellin biosynthetic and signaling pathways following GA 3treatment (2015, Vitis labrusca,Homo sapiens)
• BHBA mediates GH and PRL gene transcription, translation, and secretion in DCAPCs via the cAMP/PKA/CREB and AMPK signaling pathways (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Bos taurus,Armoracia rusticana)
• Regulatory mechanisms of actin dynamics in response to DNA damage (2015, NA)
• DNA damage-induced molecular responses for DNA repair (2015, NA)
• Nuclear entry of Cofilin-1 (CFL-1) via various stresses (2015, NA)
• Schematic depiction and overview of PI3K/AKT/PTEN signaling has been shown (2015, Curcuma longa,Citrus x paradisi,Salvia rosmarinus,Momordica charantia,Salvia officinalis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris,Human T-cell leukemia virus type I)
• Apoptosis pathways in cancer (2015, NA)
• Krüppel-like factor KLF10-mediated regulation of transforming growth factor (TGF)B signaling pathway in CD8+ and CD4+ T cells (2015, Mus musculus,Homo sapiens)
• RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL (2015, Mus musculus,Cricetus cricetus,Cricetulus migratorius,Homo sapiens,Bos taurus,Armoracia rusticana)
• Consequences of tissue trauma on heme catabolism, reactive oxygen species, and polyunsaturated fatty acid metabolism.Notes: Top panel: following tissue trauma, release of free heme can serve as a signal for proinflammatory events (2015, NA)
• Gene network, created using IPA® software, reflecting EGCG treatment.Notes: The overexpressed genes are labeled in red, while those downregulated are marked in green.Abbreviations: EGCG, epigallocatechin-3-gallate; IPA, Ingenuity®Pathway Analysis (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Sequoia sempervirens)
• TLR signaling pathway and modulation effector molecules (2015, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Vibrio cholerae,Porphyromonas gingivalis,Bacillus cereus,Staphylococcus epidermidis,Aggregatibacter actinomycetemcomitans,Mycoplasmoides pneumoniae,Streptococcus gordonii,Streptococcus sanguinis,Staphylococcus lugdunensis,Rickettsia africae,Escherichia coli O111,Saccharomyces cerevisiae,Candida dubliniensis,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Gallus gallus,Encephalomyocarditis virus)
• Epigenetic regulation in the high-salinity stress response (2015, NA)
• Epigenetic regulation in the drought stress response (2015, NA)
• Simplified overview of the central carbon metabolism, including the oxidation of methanol via Bm(Mdh-Act) or Bm(Mdh3-Act) and the assimilation of formaldehyde via the RuMP pathway of recombinant C (2015, Corynebacterium glutamicum)
• Alzheimer-related protein association network in AD-iPS5 neurons (2015, NA)
• Overlapping Alzheimer-related protein association network of AD-iPS5 neurons and of AD-iPS26B neurons (2015, NA)
• Alzheimer-related protein association network in AD-iPS26B neurons (2015, NA)
• Estimation of multi-factor mediated dysregulations affected by the module (2015, Homo sapiens,Mus musculus)
• Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing (2015, Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus)
• Platelet signaling pathways (2015, NA)
• Consequences of mutant BRAF V600E in LCH (2015, Human gammaherpesvirus 4,Vesicular stomatitis virus,Merkel cell polyomavirus,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Oryctolagus cuniculus)
• Mechanism underling the inhibition of gastric cancer progression through profilin-1 silencing (2015, NA)
• ncRNAs affect CDKIs and Myc pathway in cell cycle (2015, NA)
• ncRNAs affect Akt pathway in cell cycle (2015, NA)
• VEGF signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the VEGF signaling pathway (2015, Homo sapiens)
• Notch signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate the function of the Notch signaling pathway (2015, Homo sapiens)
• MAPK signaling pathway in the target list of hsa-miR-181a-5p based on miRTarBase 4.0.Notes: hsa-miR-181a-5p can regulate MAPK signaling pathways (2015, Homo sapiens)
• p53 pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate the p53 signaling pathway (2015, Homo sapiens)
• Cell cycle pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-miR-181a-5p can regulate a number of important proteins that control the cell cycle (2015, Homo sapiens)
• Wnt signaling pathway in the target list of hsa-miR-181a-5p, based on TarBase 6.0.Notes: hsa-181a-5p is a regulator of Wnt (2015, Homo sapiens)
• GPCR-mediated PLC/PKCB/PKD/SSH2 signaling pathway to regulate cofilin activity (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Responses of Solid Tumor Cells in DMEM to Reactive Oxygen Species Generated by Non-Thermal Plasma and Chemically Induced ROS Systems (2015, Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Rattus norvegicus,Bos taurus,Escherichia coli)
• Induction of Indoleamine 2, 3-Dioxygenase in Human Dendritic Cells by a Cholera Toxin B Subunit—Proinsulin Vaccine (2015, NA)
• Modes of cell death (2015, Homo sapiens,Mus musculus,Bikinia letestui)
• Schematic showing the activation of complement by the alternative pathway (2015, Homo sapiens,Bos taurus,Streptococcus pyogenes)
• Simplified diagram of the sphingolipid biosynthesis pathway in S (2015, Saccharomyces cerevisiae,Homo sapiens)
• Hypothetical model illustrating the MAG and the G3P pathways in TAG synthesis in the ER of enterocytes (2015, NA)
• Mixed-acid fermentation pathway in E (2015, NA)
• Proposed role of CCL21/CCR7 axis in lymphangiogenesis (2015, Homo sapiens,Mus musculus,unidentified)
• Metabolic and Chaperone Gene Loss Marks the Origin of Animals: Evidence for Hsp104 and Hsp78 Chaperones Sharing Mitochondrial Enzymes as Clients (2015, Drosophila melanogaster,Dictyostelium discoideum,Nematostella vectensis,Deuterostomia,Amoebozoa,Amphimedon queenslandica,Monosiga brevicollis,Trichoplax adhaerens,Ecdysozoa,Riftia pachyptila,Capitella teleta,Lottia gigantea,Salpingoeca rosetta,Mnemiopsis leidyi,Helobdella robusta,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Cryptococcus neoformans,Opisthokonta,Puccinia graminis,Capsaspora owczarzaki,Batrachochytrium dendrobatidis,Gonapodya prolifera,prion,unidentified,Streptococcus mutans,Streptococcus mutans S1B,Homo sapiens)
• TNFA in Cerebral Ischemia: Another Stroke Against You? (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans)
• Retinoid signaling (RA) signaling pathway (2015, NA)
• Schema of TNFA signaling pathway that induces apoptosis (2015, NA)
• Drug targets in the autophagic pathway to treat human cancers (2015, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Novel Mathematical Model Describing Adaptive Cellular Drug Metabolism and Toxicity in the Chemoimmune System (2015, NA)
• DMXAA modulates mTOR signaling pathway in A549 cells.Notes: A549 cells were treated with DMXAA 10 μM for 24 hours and the protein samples were subject to quantitative proteomic analysis (2015, NA)
• Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach (2015, NA)
• Differential beneficial or adverse effects of insulin therapy on vascular endothelial cells depending on the level of metabolic control achieved (2015, Homo sapiens)
• Hypothetical model illustrating the molecular basis of insulin-induced metabolic stress in patients with poorly controlled T2D in which both blood glucose and FFA levels are persistently elevated (2015, Homo sapiens)
• Molecular Characterization of the Peripheral Airway Field of Cancerization in Lung Adenocarcinoma (2015, Homo sapiens,Mus musculus,Asterostroma medium)
• Whole Transcriptome Analysis Using Next-Generation Sequencing of Sterile-Cultured Eisenia andrei for Immune System Research (2015, NA)
• ORF57 protein cycle (2015, NA)
• Schematic diagram showing the cross talk between HCV and miR-373 inhibiting IFN signaling (2015, NA)
• Dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity (2015, Mus musculus,Homo sapiens)
• Schematic overview of intracellular antiviral immune signaling in teleosts (2015, NA)
• NLR-mediated suppression of canonical and non-canonical NFKB signaling (2015, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Klebsiella pneumoniae,Borreliella burgdorferi,Streptococcus sp. group A,Yersinia pestis,Homo sapiens,Mus musculus,Danio rerio,unidentified influenza virus,Paracentrotus lividus)
• Mechanisms that promote resistance to PI3K pathway inhibition (2015, Homo sapiens,Mus musculus)
• The crosstalk between the IGF-1 system and estrogens in breast cancer (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Example of non-mitotic functions of Plk1: effects on the mTOR pathway (2015, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Molecular mechanism of attenuation of the PI3K/Akt signaling pathway by gingipains (2015, Porphyromonas gingivalis)
• Pathways leading to stimulation of extracellular-regulated kinase (ERK) and AKT phosphorylation by fluoxetine in astrocytes (2015, NA)
• A proposed mechanism for the adenosine A2AR agonist mediated activation of the cAMP–CREB pathway and induction of immune tolerance (2015, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Canis lupus familiaris)
• The expressed Wnt/B‐catenin pathway in the life-cycle stages (2015, Aurelia aurita,Homo sapiens)
• Proposed schematic model showing how the crosstalk between healthy or oxidized/senescent red blood cells (RBCs) and immune cells may exert anti- and proatherogenic effects, respectively (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed human innate immune signaling pathways activated during V (2015, NA)
• Proposed model in which gal-3 mediates Wnt/Beta-catenin signaling in the BMM-induced drug resistance of AL (2015, Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Integrative Multi-omics Module Network Inference with Lemon-Tree (2015, NA)
• Interplay model of Wnt/Beta-catenin, LPS/TLR4, and growth factors in ENS (2015, NA)
• Regulatory connections present in modelOur previous model of the photoperiod pathway (inset top; Song et al, ) included the circadian clock model of Locke et al () (orange, inset top) (2015, NA)
• Metabolic flux map of central carbon metabolism in cotyledons at early seed fill (2015, NA)
• Depiction of various pathways that are known to contribute to eEF2K regulation in systems biology graphical notation (SBGN) activity flow format () (2015, NA)
• Representative illustration of key gene distribution (hsa04720 and LAP_hsa04720s) (2015, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• Signaling pathways implicated in hyperstimulation of macropinocytosis and vacuolization of macropinosome-derived compartments (2015, NA)
• Molecular mechanisms regulating mitophagy (2015, NA)
• Vasoconstriction and vasodilation pathways and therapies for pulmonary hypertension (PH) (2015, Homo sapiens)
• Detailed view of protein secretion pathway (2015, NA)
• Canonical Wnt signaling pathway (2015, Homo sapiens)
• Canonical activin pathway (2015, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,clinical samples)
• Model illustrating the Ras→SAF-1/MAZ→VEGF signaling network axis (2015, Homo sapiens,Mus musculus,Bos taurus,Rat sarcoma virus)
• Indirect and direct effects seen by meformin in a preoperative window study in obese endometrial cancer patients (2015, NA)
• Metabolic disturbance in the diabetic heart and prospective therapeutic targets (2015, NA)
• Inositol phosphates and phosphoinositides(A) Inositol phosphates contain only inositol and phosphate and are therefore water soluble and cytoplasmic (2015, NA)
• Proposed model of negative regulation of autophagy during Yp infection (2015, NA)
• The main signaling pathways involved in the neuroprotective action of GDNF on dopaminergic neurons (2015, NA)
• LCBs, PA, MAPKs, and ROS in the signaling pathway in response to low temperature stress (2015, NA)
• LCBs, PA, MAPKs, and ROS in the signaling pathway involved in stomata closure as a strategy to prevent pathogen entry during an immunity response (2015, NA)
• Reconstructed primary metabolic pathways in C (2015, Auxenochlorella protothecoides)
• Simplified synopsis on the PI3K-AKT and RAS-MAPK signaling pathways and their interactions (2015, Homo sapiens,Panthera pardus)
• Structure and signaling from the cilium and relationship with the autophagic pathway (2015, NA)
• Main molecular pathways activated in the presence or absence of nutrients (2015, NA)
• Proposed model is that CD146 promotes angiogenesis and mesenchymal cell migration in melanoma (2015, NA)
• Future perspective on complement modulation in AIHA (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Overlay of gene expression on the p53 signaling pathway (2015, NA)
• Roles of FMRP in the pathogenesis of AD (2015, Homo sapiens,Mus musculus,prion)
• Pathway Express analysis of the host response to IBDV infection in the bursa (2015, NA)
• Pathway Express analysis of the host response to IBDV infection in the spleen (2015, NA)
• Synthesis of inositol pyrophosphate (2015, Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,eudicotyledons,Gossypium hirsutum,Camelina sativa,Morchella esculenta,Drosophila melanogaster,Entamoeba histolytica,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis)
• Hedgehog signaling in cancer stem cells: a focus on hematological cancers (2015, NA)
• Hedgehog signaling in cancer stem cells: a focus on hematological cancers (2015, NA)
• Placental oxidative stress triggers the expression of transcription factors to regulate angiogenesis and trophoblast invasion (2015, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Nicotiana tabacum)
• Transcriptomic changes in central metabolic pathways induced by pho13Δ during growth on different carbon sources (2015, Saccharomyces cerevisiae,Homo sapiens)
• Current model of NLRP3 inflammasome activation in RPE (2015, NA)
• Identification of Genetic Determinants of the Sexual Dimorphism in CNS Autoimmunity (2015, NA)
• Individual involvement of the products of the eight studied genes (shown in red colour) in the (a) RAS/RAF/MEK/MAPK, (b) PI3K/AKT, and (c) GNAQ/11 signalling transduction pathways (2015, Homo sapiens,Mus musculus,Danio rerio)
• Proposed pathway of cytosolic jadomycin-induced ROS and their metabolism within MCF7 breast cancer cells (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Streptomyces venezuelae,Streptomyces venezuelae ATCC 10712,Homo sapiens,Mus musculus)
• Mechanism by which TP together with HCPT induce apoptosis in A549 lung adenocarcinoma cells (2015, herbal medicine,Tripterygium wilfordii,Lonicera japonica,Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Siproeta stelenes)
• Proposed mechanism of action of glycyrrhetinic acid (GA)-induced G1-phase arrest in non-small cell lung cancer (NSCLC) cells (2015, NA)
• Competitive inhibition of survivin using a cell-permeable recombinant protein induces cancer-specific apoptosis in colon cancer model (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation (2015, Mus musculus,Rattus norvegicus,Armoracia rusticana,Malus domestica,Homo sapiens,Oryctolagus cuniculus,Pseudomonas aeruginosa,murine stem cell retroviral vector)
• Classes of pi3k/Akt/mtor signalling pathway inhibitors in breast cancer phase i, ii, and iii clinical trials (2015, Homo sapiens)
• Pi3k/Akt/mtor signalling pathway in cancer (2015, Homo sapiens)
• Transient receptor potential canonical (TRPC) channels receptor-operated Ca2+ currents (ROCs) (2015, NA)
• Egr-C/EBPB axis is regulated by Arf and oncogenic Ras (2015, NA)
• Map of central carbon metabolism highlighting CceR and AkgR targets (2015, Escherichia coli,Bacillus subtilis,Escherichia coli DH5alpha,Pseudomonas putida,Bacillus subtilis At2,Cereibacter sphaeroides,Zymomonas mobilis,Rhizobium etli,Cereibacter sphaeroides 2.4.1,Ruegeria pomeroyi,Dinoroseobacter shibae,Ketogulonicigenium vulgare,Azorhizobium caulinodans,Caulobacter vibrioides CB15,Rhodobacter capsulatus SB 1003,Caulobacter vibrioides NA1000,Azospirillum sp. B510,Rhodopseudomonas palustris CGA009,Novosphingobium aromaticivorans DSM 12444,Paracoccus denitrificans PD1222,Ruegeria pomeroyi DSS-3,Dinoroseobacter shibae DFL 12 DSM 16493,Cereibacter sphaeroides ATCC 17025,Roseobacter denitrificans OCh 114,Bradyrhizobium japonicum USDA 6,Novosphingobium sp. PP1Y,Sphingomonas sp. MM-1,Jannaschia sp. CCS1,Asticcacaulis excentricus CB 48,Diaporthe sclerotioides)
• Summary of radiation-induced persistent alterations of IGF1 and leptin signaling pathways observed in our study (2015, NA)
• Macrophage Activities in Proliferation, Lysosome, and Phagosome by the Nonspecific Immunostimulator, Mica (2015, NA)
• Clinical Proteomics Identifies Urinary CD14 as a Potential Biomarker for Diagnosis of Stable Coronary Artery Disease (2015, NA)
• Simplified illustration of the effects of IIS and TOR pathway components on physiological, developmental and behavioral traits in the pollen hoarding syndrome (2015, NA)
• Negative feedback loops at the core of transcriptional oscillators (2015, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Signalling pathway of renal tumour-propagating cell membrane markers and “cancer stem cell” markers (2015, NA)
• Signalling networks in mouse and human iPS cells (2015, NA)
• Signalling pathways that control maintenance of BCSCsWnt binds its co-receptors: Frizzled (Fz) and LRP5/LRP6 (2015, NA)
• Protein Complex Discovery by Interaction Filtering from Protein Interaction Networks Using Mutual Rank Coexpression and Sequence Similarity (2015, Homo sapiens,Saccharomyces cerevisiae)
• Dysfunction of the brain energy production system precedes Alzheimer’s disease (AD) pathology and neuronal death (2015, NA)
• Effects of melatonin on the metabolites that were involved in the carbon metabolic pathway (2015, Cynodon dactylon,Homo sapiens)
• Network graph showing interactions between ID2 and ID3 and their MIC-inferred ‘target’ genes regulating cell death (2015, NA)
• MM patient 3 profile schematic (2015, Homo sapiens,Bos taurus,Eucalyptus intertexta)
• In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants (2015, Homo sapiens,Rattus norvegicus)
• In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants (2015, Homo sapiens,Rattus norvegicus)
• In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants (2015, Homo sapiens,Rattus norvegicus)
• In Silico Functional Pathway Annotation of 86 Established Prostate Cancer Risk Variants (2015, Homo sapiens,Rattus norvegicus)
• SMAD-Independent Down-Regulation of Caveolin-1 by TGFB: Effects on Proliferation and Survival of Myofibroblasts (2015, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions (2015, NA)
• A Dlg5-mediated bifurcation in Smo activity during Hh response (2015, Armoracia rusticana,Fragaria x ananassa,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,vectors)
• Maintenance of genome stability through the heterochromatin pathway (2015, NA)
• Transepithelial transport processes and regulatory mechanisms in type A intercalated cells (A-IC) and type B intercalated cells (B-IC) (2015, NA)
• Complement activation pathways (2015, Homo sapiens)
• Immunologic synapse (2015, Homo sapiens)
• Proposed models of adiponectin metabolic pathway and associated genes (2015, NA)
• Figure can be read from the upper-left corner in an anti-clockwise direction (2015, NA)
• Fourth-ranked enriched canonical pathway identified using IPA at 2 hpi – the CD40 signaling pathway (2015, Escherichia coli,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis,Mycobacterium avium subsp. paratuberculosis,Mycobacterium avium subsp. avium,Bos taurus,Oryctolagus cuniculus,Ovis aries,Cervus elaphus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Top-ranked enriched canonical pathway identified using IPA at 2 hpi – the IL-10 signaling pathway (2015, Escherichia coli,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis,Mycobacterium avium subsp. paratuberculosis,Mycobacterium avium subsp. avium,Bos taurus,Oryctolagus cuniculus,Ovis aries,Cervus elaphus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Activation of RAS–MAPK pathway induces expression of numerous genes, some of which can be targeted (2015, Homo sapiens,Mus musculus,Vaccinia virus,NA)
• Pathways and networks associated with proteins with differential abundance according to IPA (2015, Homo sapiens,Bos taurus)
• Tumor necrosis factor (TNF) induced apoptosis pathway and the Fas-Fas ligand-mediated apoptosis pathway (2015, NA)
• Smooth muscle contraction (2015, NA)
• Cardiac muscle contraction and changes with exercise (2015, NA)
• Cilia assembly and disassembly cycle (2015, NA)
• G protein-coupled receptor pathway is involved in transmembrane signaling and diverse physiological functions including hormone signaling, regulation of cell contraction, cell migration, growth and differentiation (2015, NA)
• Treatment strategies for inactivating EBV infection or EBV-associated oncogenic pathways (2015, NA)
• Signaling pathways in T/NK-cell proliferation (2015, NA)
• Phosphorylation-independent ephrinB1 signaling (2015, NA)
• Figitumumab (CP) is a biased agonist of the IGF1R that selectively promotes Beta-arrestin1 (Beta-arr1) signaling in cancer cells (2015, NA)
• Role of TRP channels in the vascular system (2015, NA)
• Regulation of TRP channels by phospholipids and lipid rafts (2015, NA)
• Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond (2015, NA)
• Transcription of Inflammatory Genes: Long Noncoding RNA and Beyond (2015, NA)
• Coordinately up-regulated genes of WNT signaling pathway in HCV versus HIV (2015, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Sus scrofa,NA)
• Deregulation of signaling pathways and transcription factors (2015, Nicotiana tabacum,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human papillomavirus,Bikinia letestui,Phleum pratense,Alphapapillomavirus 7,Rhodostemonodaphne grandis,Oryzias latipes,Rutilus frisii,Homo sapiens,Mus musculus,Drosophila melanogaster,Thylacinus cynocephalus)
• Working model of GIV’s role in early podocyte injury in PAN nephrosis (2015, NA)
• Differential effects of leptin and adiponectin in vascular endothelium (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Schematic figure of the complement system (2015, NA)
• EGFR signaling and targeted therapies (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Patella vulgata)
• KDEL ligand and receptor in chaperone retrieval and retention within the ER and escape into the cytosol (2015, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Trypanosoma cruzi)
• Effect of four different chemicals on inflammation-associated insulin signaling pathway in HepG2 cells (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,H5N1 subtype)
• Mechanisms by which HNE up-regulates Cox-2 (2015, Mus musculus,Rattus norvegicus,Rattus rattus,Rattus sp.,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,Moloney murine leukemia virus,NA)
• PTEN-PI3K-AKT pathway in oocytes regulates primordial follicle activation (2015, Homo sapiens)
• Actin polymerization disrupts ovarian Hippo signaling and promotes nuclear YAP actions to increase downstream CCN growth factors and apoptosis inhibitors involvement in POI, PCOS, follicle reserve, and infertility (2015, Homo sapiens)
• Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization (2015, NA)
• An example from dGCspALL2 (2015, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Metabolic network of tomato cells (2015, Solanum lycopersicum)
• Toll-like receptors and IL-1 receptor family signaling pathways (2015, NA)
• Imd pathway in the fruit fly and the TNF pathway in the mouse (2015, Mus musculus,Homo sapiens)
• Toll pathway in the fruit fly and the Toll-like receptor (TLR) 4 pathway in the mouse (2015, Drosophila melanogaster,Mus musculus,Homo sapiens)
• Signal transduction by HER-family (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Core Hedgehog pathway and its cross talks (2015, Homo sapiens,Escherichia coli,Drosophila melanogaster,Nitzschia alba)
• Nuclear factorK B activation pathways (2015, NA)
• Schematic drawing of the signaling pathway by which Melatonin stimulates dendrite formation (2015, NA)
• Some possible signaling pathways activated by SF-CSNPs which may regulate metabolism of proliferating cells through Ubiquitin C (UBC) (2015, NA)
• Protein–protein interaction pathways are illustrated (2015, NA)
• Lipids regulate apoptotic signaling in the cells (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli,Taxus cuspidata,NA,NA)
• Predicted target genes involve the KEGG pathway-mediated regulatory network in the hyperoxia model rats (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Network view of (A) 104, (B) 188, and (C) 299 putative drug-resistant cross-talks between pathways using Reactome, KEGG, and WikiPathway pathway databases in Breast Cancer Cell-line: SKBR3 (GSE38376) (2015, Homo sapiens,Mus musculus)
• Differentially expressed genes in appetite control pathway between grass carp before and after food habit transition from transcriptome analysis (2015, NA)
• Differentially expressed genes in cell proliferation and differentiation pathway between grass carp before and after food habit transition from transcriptome analysis (2015, NA)
• Schematic presentation for araguspongine C-induced autophagic death in breast cancer cells (2015, NA)
• Luciferase Reporter Gene Assay on Human 5-HT Receptor: Which Response Element Should Be Chosen? (2015, NA)
• Pathway enrichment results: (A) hsa05200 (pathway in cancer); (B) hsa05218 (melanoma) (2015, Homo sapiens)
• Hereditary hemorrhagic telangiectasia is a genetically heterogeneous disorder caused by mutations in several genes in the TGFB/BMP signaling pathway (2015, NA)
• Interaction of HBV and TLR2/4 (2015, Hepatitis B virus,Woodchuck hepatitis virus,Stealth virus 1,Homo sapiens,Mus musculus,Pan troglodytes,Marmota monax)
• Working hypothesis for how the PGRN/PIRO axis regulates the formation of multinucleated osteoclasts (2015, NA)
• Thymidine metabolism in the cytosol and mitochondrial matrix (2015, Rattus norvegicus,Homo sapiens)
• Metabolic reconstruction for Candidatus Iainarchaeum andersonii genome (2015, Candidatus Iainarchaeum andersonii)
• Metabolic scheme of ectoine, glutamate and proline synthesis and catabolism inferred from the Nitrosopumilus genomes (2015, NA)
• Effects of the clock on apoptosis (2015, NA)
• The mammalian DNA damage checkpoint pathways and/or systems (2015, NA)
• Computational Approach to Identifying Gene-microRNA Modules in Cancer (2015, Homo sapiens,herbal medicine,NA)
• Computational Approach to Identifying Gene-microRNA Modules in Cancer (2015, Homo sapiens,herbal medicine,NA)
• microRNA-21 Mediates Stretch-Induced Osteogenic Differentiation in Human Periodontal Ligament Stem Cells (2015, Homo sapiens)
• MiR-101 network regulates EMT (2015, Homo sapiens,Mus musculus,Hepatitis B virus,Brachylaena ramiflora,NA)
• Proposed mechanisms accounting for resistance to inhibitors of the PI3K pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Networking of the PI3K/Akt/mTOR signaling pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic involvement of TREK-1/sortilin complex in the 5-HT transmission (2015, Homo sapiens,Mus musculus)
• Examples of PTM-mediated biological processes (2015, NA)
• The nitrergic system and its downstream effects in hippocampal neurons following stress exposure (2015, NA)
• Pathway analysis in groups A (A) and B (B) (2015, Homo sapiens,Mus musculus)
• Working model for rotavirus cell entry into MA104 cells (2015, NA)
• Influence of An (2015, Anopheles gambiae,Plasmodium falciparum,Homo sapiens,NA)
• Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma (2015, Homo sapiens,Mus musculus,unidentified)
• Signalling of the PI3K/AKT/mTOR pathway and relevant drugs that target each of the components of the pathway (2015, NA)
• PI3K in the biology of B cells (2015, NA)
• A, Diagram of the prostaglandin synthesis pathway including relative expression values (arbitrary units) for synthetic enzymes and receptors from our previously reported microarray analysis of bovine growth plate chondrocytes () (2015, Homo sapiens,Mus musculus,Bos taurus)
• Generalized central metabolic pathway adapted and modified from a previous study (2015, NA)
• Schematic diagram on pathogenesis of diabetic nephropathy (2015, NA)
• Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation (2015, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• The WNT signaling network on cancer cell metabolism (2015, NA)
• WNT signaling network (2015, NA)
• mTOR signaling pathway regulated by PLB in DU145 cells.Notes: DU145 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis (2015, Homo sapiens)
• mTOR signaling pathway regulated by PLB in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis (2015, Homo sapiens)
• PLB regulates apoptosis signaling pathway in PC-3 cells.Notes: PC-3 cells were treated with 5 μM PLB for 24 hours and the protein samples were subject to quantitative proteomic analysis (2015, Homo sapiens)
• Schematic representation of relaxin signaling pathways leading to activation of PPARG (2015, NA)
• CCR7-stimulated phosphorylation-inhibition of AMPK (2015, Homo sapiens)
• Intestinal translocation of K (2015, NA)
• Activation of TLR4 by LPS (2015, Candida dubliniensis)
• Proposed mechanisms of LPS-induced suppression of mitochondrial biogenesis in the renal cortex (2015, NA)
• Schematic overview of the proposed mechanisms of HMGB1 release and its biological activity after acute stroke (2015, Homo sapiens,Mus musculus)
• Signalling through K opioid receptors (KOPr) induced by dynorphin or TRK820 regulates VEGF signalling, especially VEGFR2 expression, by activating the cAMP/PKA pathway in ECs (2015, Homo sapiens)
• Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase (2015, Homo sapiens)
• The CWI pathway and its activation by sensor clustering (2015, Saccharomyces cerevisiae,Homo sapiens)
• RLR Signaling pathway (2015, NA)
• Signaling pathway of endosomal TLRs (2015, NA)
• Signaling pathway of cell surface TLRs (2015, NA)
• Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway (2015, NA)
• ETA receptor-mediated VSMC signalling pathways (2015, Mus musculus,Rattus norvegicus,Cavia porcellus,Sus scrofa,Ovis aries,Pollachius virens,Salminus brasiliensis,Homo sapiens)
• Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms (2015, Homo sapiens,Mus musculus,vectors)
• TGFB–dependent regulation of VEGF release in glioblastoma (2015, NA)
• Intracellular signaling of mTORC1 and mTORC2 (2015, Homo sapiens)
• Possible mechanism of ciglitazone-mediated protection on endothelial cells against ox-LDL-induced injury through activating PPARGamma-dependent AMPK signalling pathway (2015, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• N-terminal tyrosine residues of SLP-76 on the canonical TCR signaling pathway (2015, NA)
• Malonylated proteins in glucose and fatty acid metabolism pathways (2015, Homo sapiens,Mus musculus)
• MiR-15 family and its targets in the INSR signalling pathway (2015, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Mouse mammary tumor virus,Sequoia sempervirens,Avian sarcoma virus CT10,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Protein Interactome of Muscle Invasive Bladder Cancer (2015, Homo sapiens,Mycobacterium tuberculosis variant bovis BCG)
• Protein Interactome of Muscle Invasive Bladder Cancer (2015, Homo sapiens,Mycobacterium tuberculosis variant bovis BCG)
• Scheme of interactions hypothesized to connect the receptor protein Draper to the execution of the engulfment process (2015, Drosophila melanogaster,Homo sapiens)
• Main glucose degradation pathways in the heart (2015, NA)
• Signaling model for IP-10 production induced by MRP8/MRP14 (2015, NA)
• Coffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of AB oligomerization and modulation of the Tau-mediated pathway in N2a/APP cells (2015, NA)
• Capecitabine activation and subsequent 5-FU activation, action, transport and catabolism (2015, NA)
• Proposed mechanisms for ischemia/reperfusion injury and for microvascular protection elicited by n-3 polyunsaturated fatty acids (n-3 PUFA) (2015, Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens,Olea europaea)
• Involvement of the IRE1Alpha-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic Diseases (2015, NA)
• Retinoic acid (RA) synthesis pathway in the gut (2015, NA)
• Sodium reabsorption in the mammalian renal tubule (2015, NA)
• Differential expression in LCI (2015, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,Encephalomyocarditis virus,H3N2 subtype,Homo sapiens,Gallus gallus,Osphranter robustus)
• To reveal potential pathways involved in pancreatic cancer survival, the Ingenuity Pathway Analysis (IPA) was used for upstream regulator analysis (2015, Homo sapiens,Diaporthe sclerotioides)
• Summary of mitochondrial protein changes in aox1a:rpoTmp under standard growth conditions (2015, NA)
• Proposed model for H2O2 stimulation of CFTR (2015, NA)
• RBP-J acts as a master regulator that maintains the identity of the JG cell (2015, Mus musculus,Homo sapiens)
• Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis (2015, Mycobacterium tuberculosis,Homo sapiens)
• SAMe and MTA inhibit Beta-catenin signaling in liver and colon cancer cells by multiple mechanisms (2015, Mus musculus,Homo sapiens)
• ROCK activation of YAP/TAZ-TEAD–directed profibrotic gene expression (2015, Homo sapiens)
• ROCK activation of MTRF-SRF–directed profibrotic gene expression (2015, Homo sapiens)
• Gene set variation analysis of the antigen processing and presentation pathway (APP) and the natural killer (NK) cell gene set (2015, NA)
• Possible mechanisms for the hypoglycemic effects of LBPs.Notes: LBPs significantly promote glucose uptake involving several signaling pathways in the liver and muscle (2015, NA)
• Proposed underlying mechanism for the effect of SCE on drug metabolizing enzymes and drug transporters via Nrf2-mediated signaling pathway (2015, NA)
• PPAR signalling pathway (2015, NA)
• Skeletal muscle metabolism in control and Acsl1M−/− mice (2015, Mus musculus,Rattus norvegicus,Homo sapiens)
• Chitotriosidase in the Pathogenesis of Inflammation, Interstitial Lung Diseases and COPD (2015, NA)
• Network analysis of genes significantly modulated in response to mood stabilisers (2015, Mus musculus,Rattus norvegicus,Betapolyomavirus macacae,Gibbon ape leukemia virus,Homo sapiens,Bos taurus,unidentified,Citrus medica,Phengaris arion)
• Cell cycle pathway (2015, Mus musculus,Rattus norvegicus,Homo sapiens,Pandion haliaetus)
• C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NFKB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells (2015, Mus musculus,Homo sapiens)
• Signal transducer and activator of transcription 3 (STAT3) pathways involved in immune escape (2015, Homo sapiens)
• Aberrant miRNA expression in liver cancer affects the functionality of apoptosis pathways (2015, NA)
• Aberrant miRNA expression in liver cancer promotes cell-cycle progression (2015, NA)
• Mitochondrial dysfunction and insulin resistance: an update (2015, Mus musculus,Rattus norvegicus,Candida dubliniensis,Vaccinium vitis-idaea,Homo sapiens,Oryctolagus cuniculus,Limosilactobacillus fermentum)
• Proposed role of stem-progenitor cells in leiomyoma pathogenesis (2015, Homo sapiens)
• Proposed model for autophagy and metastasis mediated by mTOR signaling (2015, NA)
• Zinc-mediated pathways by which external stimuli (such as systemic glucose, cytokines and zinc) may act on cellular function (2015, NA)
• Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway (2015, NA)
• AKT suppresses the HR pathway and activates the NHEJ pathway via many mechanisms (2014, NA)
• AKT's role in the NER pathway (2014, NA)
• Proposal model for regulation of FMV in placental vasculature in response to exercise (2014, NA)
• Action of recombinant bovine somatotropin (rBST) (2014, herbal medicine,Silybum marianum,Trigonella foenum-graecum,Lolium arundinaceum,Ambrosia artemisiifolia,Myrrhis odorata,Cuminum cyminum,Lepidium sativum,Galega officinalis,Asparagus racemosus,Pimpinella anisum,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Felis catus,Escherichia coli,Escherichia coli IS1,Streptococcus uberis,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• CB2 Cannabinoid Receptors as a Therapeutic Target—What Does the Future Hold? (2014, NA)
• BRAF inhibitors on melanoma and immune cells (2014, Homo sapiens)
• Wnt signaling as a pathway to increase bone formation (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens)
• Metabolic pathway of Cytokines in humans (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Intracellular pathway associated with IGF1R activation (2014, NA)
• Intracellular pathway associated with GHR activation in hepatocytes (2014, NA)
• Signaling of NGF receptors (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bromus secalinus)
• Metabolic pathway of Inflammatory Response in humans (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Model for NRF2 regulation in BRCA1-associated tumorigenesis (2014, Mus musculus,Homo sapiens)
• Evolution of the GPCR Signaling System in Eukaryotes: Modularity, Conservation, and the Transition to Metazoan Multicellularity (2014, NA)
• Stress-induced premature senescence (SIPS) signaling pathway (2014, NA)
• Role of intra-cytoplasmic pattern recognition receptors during RSV infection (2014, unidentified influenza virus,Respiratory syncytial virus,Measles morbillivirus,Human orthopneumovirus,Human metapneumovirus,Murine orthopneumovirus,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes)
• Role of Toll-like receptors during RSV infection (2014, unidentified influenza virus,Respiratory syncytial virus,Measles morbillivirus,Human orthopneumovirus,Human metapneumovirus,Murine orthopneumovirus,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes)
• Integrated signaling networks and tumor cellular bioenergetics (2014, NA)
• Schematic representation summarizing the mechanism concerning neuroprotective actions of PACAP in neurodegenerative diseases (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Innate recognition of HCV RNA (2014, Homo sapiens)
• LIF signaling and post-translational modifications of some stemness transcription factors (2014, NA)
• MicroRNA and their involvement in oncologenic signaling cascades in pancreatic cancer (2014, NA)
• Simplified overview of the Rb/E2F pathway (2014, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Juniperus chinensis,Betapolyomavirus macacae,Polyomavirus sp.,Betapolyomavirus hominis,Streptomyces sp.,Saccharolobus solfataricus,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Neurofibromin structure and function (2014, NA)
• Overexpression of miR-125a in Myelodysplastic Syndrome CD34+ Cells Modulates NFKB Activation and Enhances Erythroid Differentiation Arrest (2014, NA)
• VASP Activation via the GA13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation (2014, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Citrullus colocynthis,Alsomitra macrocarpa,Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Schematic for reprogramming of EBV-induced glucose metabolism (2014, Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana,NA)
• Pro-Proliferative Effects of Nicotine and Its Underlying Mechanism on Rat Airway Smooth Muscle Cells (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Cavia porcellus,Equus asinus,Homo sapiens,Nicotiana tabacum)
• Neurostimulant para-Chloroamphetamine Inhibits the Arginylation Branch of the N-end Rule Pathway (2014, NA)
• NFAT5/REDD1/mTOR/Notch pathway model (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Genome Information of Methylobacterium oryzae, a Plant-Probiotic Methylotroph in the Phyllosphere (2014, Methylobacterium oryzae)
• Caveolin Contributes to the Modulation of Basal and Beta-Adrenoceptor Stimulated Function of the Adult Rat Ventricular Myocyte by Simvastatin: A Novel Pleiotropic Effect (2014, Mus musculus,Rattus norvegicus,Candida dubliniensis,Campanula medium,Homo sapiens,Gallus gallus,Equus asinus)
• Pathways implicated in type I IFN production following L (2014, Escherichia coli,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Chlamydia trachomatis,Francisella tularensis,Mycobacterium leprae,Streptococcus sp. group B,Francisella tularensis subsp. novicida,Chlamydia muridarum,Homo sapiens,Mus musculus,unidentified influenza virus)
• Genomic aberration of the proliferative and invasive pathways of glioma signalling (2014, NA)
• Multiple mechanisms lead to the development of PPCM in mice (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Osphranter robustus)
• VEGF Action on MVECs of Blood-Neural BarriersThe majority of VEGFR1 and VEGFR2 is found on the apical (luminal) and basal (abluminal) side, respectively, of brain or retinal MVECs (2014, NA)
• Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells (2014, NA)
• Rho-GTPases as key regulators of T lymphocyte biology (2014, Mus musculus,Homo sapiens)
• Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host (2014, NA)
• Receptors and signaling pathways involved in proliferation and differentiation of Sertoli cells (2014, NA)
• The relationship between RAGE and neurite outgrowth after spinal cord injury (2014, NA)
• Identified glycotransferases involved in O-glycosylation and associated biosynthetic pathway (2014, NA)
• Epigenetics and the Evolution of Darwin’s Finches (2014, NA)
• Epigenetics and the Evolution of Darwin’s Finches (2014, NA)
• Epigenetics and the Evolution of Darwin’s Finches (2014, NA)
• Metabolic Control of Redox and Redox Control of Metabolism in Plants (2014, NA)
• NFKB Dependent and Independent Actions of the IKKs (2014, NA)
• ChREBP activation is shown (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• PI3K/Akt/mTOR signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• O-GlcNAc and cancer metabolism (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Schematic model of TGFB signaling pathways for CRP2 induction in VSMCs (2014, NA)
• Signaling pathway that metformin uses to regulate T cell and osteoclasts in autoimmune arthritis (2014, Homo sapiens,Mus musculus,Gallus gallus)
• Cell signal pathway that p42 utilizes to suppress tumor growth by controlling PI3K activity through UPS (2014, Bos taurus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Adeno-associated virus,adeno-associated virus 2,Homo sapiens)
• Schematic diagram showing differences in the thyroid cancer cell lines sensitive or resistant to apoptosis (2014, NA)
• Simplified representation of the regulation of actin cytoskeleton pathway and differentially regulated genes (2014, Diaporthe sclerotioides,Cladophora subtilissima,Homo sapiens,Rattus norvegicus,Bos taurus)
• Bcl-2 protein family in apoptosis and hematologic malignancies (2014, Homo sapiens,Mus musculus,Gallus gallus,Canis lupus familiaris,NA)
• Role of RNase L and TLR3 activation during inflammation in insulin response of obese people's myotubes (2014, NA)
• Schematic model shows the downstream signaling pathway of PIP5K1A and the effect of ISA-2011B inhibition (2014, NA)
• Cotargeting the PI3K/AKT and AR pathways in CRPC (2014, NA)
• Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues (2014, NA)
• Proposed pathway for digitoflavone-induced Nrf2/ARE-mediated cytoprotective proteins via activation of p38 MAPK signaling (2014, Malus domestica,Allium cepa,Theobroma cacao,Daucus carota,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Psidium guajava,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Plasmodium bottleneck: malaria parasite losses in the mosquito vector (2014, Drosophila melanogaster,Plasmodium falciparum,Aedes aegypti,Anopheles gambiae,Plasmodium berghei,Plasmodium vivax,Culex quinquefasciatus,Plasmodium yoelii,Anopheles stephensi,Anopheles quadrimaculatus,Plasmodium gallinaceum,Anopheles funestus,Anopheles aquasalis,Anopheles albimanus,Anopheles arabiensis,Plasmodium falciparum 7G8,Plasmodium cynomolgi,Anopheles culicifacies,Anopheles culicifacies B,Streptococcus pyogenes,Borreliella burgdorferi,Serratia marcescens,Homo sapiens,Macaca sinica,Mus musculus,Saccharomyces cerevisiae,Human immunodeficiency virus)
• Cholesterol metabolism, lipid rafts and autism spectrum disorders (2014, Homo sapiens,Mus musculus)
• MOR activation pathway leading to ICa inhibition in the VANs (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Diaporthe sclerotioides,Terfezia morenoi,Homo sapiens,Canis lupus familiaris,Ambystoma mexicanum)
• Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk (2014, Homo sapiens,Mus musculus,Bos taurus,Solanum lycopersicum)
• Pathway analysis (2014, NA)
• Differential diagnosis of glomerular disease based on complement system pathway activation (2014, NA)
• Positive feedback loop between EGFR and ERA36.Notes: A positive feedback loop has been confirmed that EGFR signaling activates transcription of ERA36 through an AP-1-binding site in the promoter region of ERA36 (2014, Homo sapiens,Mus musculus,Broussonetia papyrifera)
• Dual role of Nrf2 in cancer.Notes: As long as it is kept under homeostatic control, Nrf2 activation protects cellular components like DNA from damaging insults arising from acute/temporary oxidative and xenobiotic stress (2014, NA)
• Pathways of sphingolipid degradation and synthesis (2014, NA)
• Actions and interactions of the HSP network required for normal protein folding and refolding upon acute stress or during chronic stress (2014, NA)
• mGluR1-TRPC3 signaling at parallel fiber-Purkinje cell synapses (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hepatitis C virus entry into hepatocytes (2014, Homo sapiens,NA)
• Re-evaluation of liver stem/progenitor cells (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus - 8)
• Mechanical offloading of incisional wounds is associated with transcriptional downregulation of inflammatory pathways in a large animal model (2014, Sus scrofa,Homo sapiens)
• Grape Seed Proanthocyanidins (GSPs) Inhibit the Growth of Cervical Cancer by Inducing Apoptosis Mediated by the Mitochondrial Pathway (2014, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Pronounced Metabolic Changes in Adaptation to Biofilm Growth by Streptococcus pneumoniae (2014, NA)
• Src Is Required for Mechanical Stretch-Induced Cardiomyocyte Hypertrophy through Angiotensin II Type 1 Receptor-Dependent Beta-Arrestin2 Pathways (2014, Mus musculus,Rattus norvegicus,Bos taurus,Homo sapiens)
• The hypothetical estrogen-induced signaling pathway in neurons (2014, NA)
• Aldosterone Induced Galectin-3 Secretion In Vitro and In Vivo: From Cells to Humans (2014, NA)
• Immunohistochemical Analysis of the Mechanistic Target of Rapamycin and Hypoxia Signalling Pathways in Basal Cell Carcinoma and Trichoepithelioma (2014, Homo sapiens,Mus musculus,Bos taurus,Petrocephalus catostoma)
• The impact of agmatine on the molecular and metabolic pathways (2014, NA)
• A simplified model of some of the signaling pathways leading to LTD of the pf-PC synapse (2014, NA)
• TGFB/Smad signaling during hepatic fibro-carcinogenesis (Review) (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• Apoptosis induction and signaling (2014, Calloplesiops altivelis,Dinosauria,Homo sapiens,Mus musculus,Rous sarcoma virus,Hammada scoparia)
• Interaction network using Pathway studio (2014, NA)
• Biological network inferences for a protection mechanism against familial Creutzfeldt-Jakob disease with E200K pathogenic mutation (2014, NA)
• “RAS”ling B cells to proliferate for diabetes: why do we need MEN? (2014, NA)
• Toll-like receptor 4 (TLR4) signaling pathway by Lactobacillus casei OLL2768, Bifidobacterium adolescentis MCC-75, and Bifidobacterium adolescentis ATCC15705 in bovine intestinal epithelial epitheliocytes (BIE cells) (2014, NA)
• Tumor’s interaction with its solid microenvironment (2014, Calloplesiops altivelis,Dinosauria,Homo sapiens,Mus musculus,Rous sarcoma virus,Hammada scoparia)
• Signaling pathways that induce epithelial–mesenchymal transition (EMT) (2014, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• So-called PI3-K/Akt/mTOR survival pathway (2014, Calloplesiops altivelis,Dinosauria,Homo sapiens,Mus musculus,Rous sarcoma virus,Hammada scoparia)
• Functional relevance of rapid transcriptional silencing in activated DCs (2014, Homo sapiens,Gorilla gorilla,Mus musculus,Candida dubliniensis)
• Inferred non-small cell lung cancer pathway using the SpliceNet and RNASeqNet (2014, NA)
• Gene regulatory network in three hybrid combinations (2014, NA)
• miRNAs involved in angiogenic process (2014, NA)
• An overview of oncogenic KRAS-driven RAF/MEK/ERK and PI3K/PDK1/AKT signalling networks in pancreatic cancer (2014, Homo sapiens,Mus musculus,Plasmid pTF1)
• The different estrogen signaling pathways (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Plasma ADMA level is controlled by DDAH (2014, NA)
• CREB-dependent cell cycle factor expression signalling network in GBM tumour cells (2014, NA)
• Hypothetical model to describe the mechanisms and outcomes of MAPK activation induced by different levels of ROS (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Apoptosis pathway (2014, NA)
• Regulation of apoptosis by sphingolipids (2014, NA)
• Gene Expression Profiling Reveals Epithelial Mesenchymal Transition (EMT) Genes Can Selectively Differentiate Eribulin Sensitive Breast Cancer Cells (2014, Homo sapiens,Rattus norvegicus,Eucalyptus intertexta)
• Relationships between Signaling Pathway Usage and Sensitivity to a Pathway Inhibitor: Examination of Trametinib Responses in Cultured Breast Cancer Lines (2014, NA)
• MAPK signalling cascades leading to MK5 activation (2014, Homo sapiens,Mus musculus,Human papillomavirus,Dipturus trachyderma,Panthera onca,NA)
• Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms (2014, NA)
• Lithium-mediated suppression of neuroinflammation (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Polygala tenuifolia)
• Relationship between PI3-K–Akt–mTOR signaling and autophagy in muscular dystrophy (2014, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Macaca mulatta,Saccharomyces cerevisiae,Drosophila melanogaster,Moolgarda engeli)
• MAPK signaling pathway (2014, NA)
• Differentially expressed genes (DEGs) in the T-cell receptor signaling pathway (2014, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Diaporthe sclerotioides,prion)
• Differentially expressed genes (DEGs) in the B-cell receptor signaling pathway (2014, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Diaporthe sclerotioides,prion)
• Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database (2014, NA)
• Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation (2014, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Methanocorpusculum labreanum)
• Janus kinase 2 (JAK2)/signal transducer and activation of transcription (STAT) and hedgehog (Hh) signaling pathways in normal development (A) and mechanisms of Hh signaling in cancer (B) (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Paraechinus aethiopicus,Myeloproliferative leukemia virus)
• MAPK pathway as an apoptosis enhancer in melanoma (2014, NA)
• Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention (2014, NA)
• Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention (2014, NA)
• Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention (2014, NA)
• Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention (2014, NA)
• Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention (2014, NA)
• Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention (2014, NA)
• Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands (2014, NA)
• Proposed mechanisms of protective role of TRB3 in diabetic kidney disease (2014, NA)
• EGFR associated signaling pathways in lung cancer (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Apoptosis induction by the HIV-1 envelope protein at the cell surface (2014, NA)
• Involvement of HIV proteins in intrinsic apoptotic pathways: The viral proteins are marked in yellow (2014, NA)
• Apoptosis works through two main, alternative pathways: death receptor-mediated (or extrinsic) and mitochondria-dependent (or intrinsic) (2014, NA)
• MTOR signaling pathway (2014, NA)
• MTOR pathway in T cells (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Hepatitis B virus)
• Infectious tolerance that depends on a nutrient depleted microenvironment maintained by Treg cells within tissues (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Hepatitis B virus)
• Mycobacterium bovis BCG Triggered MyD88 Induces miR-124 Feedback Negatively Regulates Immune Response in Alveolar Epithelial Cells (2014, Mycobacterium tuberculosis,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis variant bovis BCG str. China,Homo sapiens,Mus musculus,Bos taurus,artificial sequences)
• Molecular mechanisms and biomarkers in type 2 diabetes (2014, Homo sapiens)
• Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis (2014, Bacillus subtilis)
• Post-Transcriptional Regulation of Cytokine Signaling by AU-Rich and GU-Rich Elements (2014, NA)
• Induction of PGC1-Alpha-mediated mitochondrial biogenesis by resveratrol, bezafibrate and AICAR (2014, NA)
• Working model of S (2014, Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli DH5alpha,Escherichia coli BL21,Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344,Mus musculus,Rattus norvegicus,Homo sapiens,Influenza A virus)
• In Silico Determination of the Effect of Multi-Target Drugs on Calcium Dynamics Signaling Network Underlying Sea Urchin Spermatozoa Motility (2014, Paracentrotus lividus,Strongylocentrotus purpuratus,Parechinus angulosus,Arbacia punctulata,Lytechinus pictus,Mus musculus,Rattus norvegicus,Cavia porcellus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Arabidopsis thaliana,Canis lupus familiaris,Homo sapiens,Xenopus laevis)
• Profile of pacritinib and its potential in the treatment of hematologic disorders (2014, NA)
• Non-selective autophagy regulation during diabetic nephropathy (DN) (2014, Homo sapiens)
• E-cadherin regulated signaling pathways involved in gastric cancer (2014, Homo sapiens,Helicobacter pylori)
• ATX and the Akt/Bad pathway mediating anti-apoptotic signals and alleviating early brain injury after subarachnoid hemorrhage (SAH) (2014, NA)
• Schematic presentation of the Nrf2 pathway (2014, NA)
• Regulatory networks of miRNAs and PI3K/AKT pathway in controlling EMT and cancer stemness in human tumors including endometrial cancer (2014, Homo sapiens,Mus musculus)
• Mitochondrial regulation of calcium clearance: a point of convergence for retrograde and anterograde signalling (2014, NA)
• Hypothesized mechanism of action of exemestane on MPM cells (2014, Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Psidium guajava,Homo sapiens,Mus musculus,Betapolyomavirus macacae)
• Energy Metabolism during Anchorage-Independence. Induction by Osteopontin-c (2014, Homo sapiens,Mus musculus,Bos taurus,Mouse mammary tumor virus,Corvus corax)
• Genistein modulates a critical TGFB signaling pathway in human prostate cancer (2014, Homo sapiens,Glycine max)
• Model expressing the distinct molecular pathways of ER transcription factors regulatory actions (2014, NA)
• Mitochondrial unfolded protein response (UPRMT) in C (2014, NA)
• Top-ranked enriched canonical pathway identified using IPA, the T-cell receptor signaling pathway (2014, Escherichia coli,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis,Mycobacterium intracellulare subsp. intracellulare,Bos taurus,Meles meles,Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Middle East respiratory syndrome-related coronavirus)
• Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer (2014, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Nicotiana tabacum,Branchiostoma lanceolatum)
• Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease (2014, NA)
• Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease (2014, NA)
• Molecular pathways are altered due to modulation of signaling pathway in skin cancer (2014, NA)
• Canonical and noncanonical TGFB signaling (2014, Homo sapiens)
• SIRT6 as a master regulator of glucose metabolism (2014, NA)
• Activation and regulation of the JAK-STAT pathway (2014, Homo sapiens)
• Signaling crosstalk between the TGF-Beta-activated pathway and other pathways during EMT (according to Xu et al (2014, NA)
• Schematic illustrations for potential signaling pathway of IMF deposition in skeletal muscles regulated by GHR and SOCS3 (2014, NA)
• FASN related metabolic and signal transduction pathways (2014, Nicotiana tabacum,herbal medicine,Panax ginseng,Allium cepa,Allium sativum,Zingiber officinale,Scutellaria baicalensis,Carica papaya,Angelica sinensis,Litchi chinensis,Morus alba,Polygonum cuspidatum,Paeonia lactiflora,Sophora flavescens,Wolfiporia cocos,Atractylodes macrocephala,Symphonia globulifera,Fallopia multiflora,Areca catechu,Cinnamomum aromaticum,Tetradium ruticarpum,Myrrhis odorata,Rosa chinensis,Epimedium brevicornu,Pinellia ternata,Prunella vulgaris,Scutellaria barbata,Styphnolobium japonicum,Rosa rugosa,Selaginella tamariscina,Crataegus pinnatifida,Illicium verum,Allium fistulosum,Spatholobus suberectus,Gleditsia sinensis,Sanguisorba officinalis,Nephelium lappaceum,Mentha canadensis,Eclipta prostrata,Lindera aggregata,Apocynum venetum,Toxicodendron succedaneum,Pyrrosia lingua,Leptogorgia ramulus,Schlechtendalia chinensis,Homo sapiens,Mus musculus,NA)
• NFKB and p53 antagonises each others activity (2014, NA)
• Activation of NFKB signaling through canonical and alternative pathways (2014, NA)
• Representation of the p53 signaling pathway map from KEGG (2014, NA)
• Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• LTP pathway components and interacting proteins: response in hippocampus (2014, NA)
• Precision medicine and personalized breast cancer: combination pertuzumab therapy (2014, Homo sapiens,Mus musculus)
• Mitochondrial ROS generation, neutralization, macromolecular damage and repair (2014, NA)
• Schematic view of the sphingolipid metabolism in S (2014, NA)
• EGAN analysis showing all the differentially expressed enriched pathway genes (2014, NA)
• In renal cancer cells, stem cell factor (SCF) binding to the c-Kit receptor (c-KitR) induces several signal transduction pathways that lead to its proliferation, invasion, survival, and angiogenesis (2014, NA)
• Wnt/Beta-catenin signaling pathway (2014, Xenopus laevis,Opsanus beta,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Wnt/Beta-catenin signaling pathway (2014, NA)
• Activation or inhibition of a cell by Fc receptor ligation of IgG immune complexes (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Sclerogenia jessica)
• The role of Wnt, Notch, TGFB and Hif-1A signalling in hepatocytes, cholangiocytes and liver progenitor cells in hepatocarcinogenesis (2014, NA)
• Metabolic pathway of prostaglandins via cyclooxygenase (2014, Homo sapiens)
• miRNA- and TF-mediated sub-network specific to the TGFB signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Robustness and Plasticity of Metabolic Pathway Flux among Uropathogenic Isolates of Pseudomonas aeruginosa (2014, Pseudomonas aeruginosa,Homo sapiens)
• GPSM3 function in regulating Gi-coupled chemokine receptors (2014, NA)
• Integrating Multi-Omics for Uncovering the Architecture of Cross-Talking Pathways in Breast Cancer (2014, Homo sapiens,Venustaconcha ellipsiformis)
• Transcriptional Profiling in Rat Hair Follicles following Simulated Blast Insult: A New Diagnostic Tool for Traumatic Brain Injury (2014, NA)
• Multi-Level Kinetic Model Explaining Diverse Roles of Isozymes in Prokaryotes (2014, Escherichia coli,Synechocystis sp. PCC 6803,Synechocystis sp.,Synechococcus elongatus PCC 6301,Synechococcus elongatus PCC 7942 FACHB-805,Chlamydomonas reinhardtii)
• Human respriatory syncytial virus (hRSV) recognition by airways epithelial cells: upon infection, different hRSV components activate pattern recognition receptors (PRRs) (2014, NA)
• Hallmarks of AD, progression of the disease and mitochondrial dysfunction (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Arctium lappa,Salvia sahendica,Homo sapiens)
• Figures accompanying the sensitivity analysis (2014, Homo sapiens,Rattus norvegicus,unidentified,Coxsackievirus B3,Leuciscus leuciscus,Capsicum pubescens)
• Hyperglycemia-induced pathways leading to epigenetic alteration (2014, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens)
• Interplay between Wnt signaling and other anti-ageing pathways (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Arctium lappa,Salvia sahendica,Homo sapiens)
• Conceivable transforming growth factor (TGF)B1-initiated cellular events leading to myofibroblast activation and extracellular matrix (ECM) synthesis culminating into renal fibrosis (2014, NA)
• Schematic representation depicting deleterious effects of overnutrition and obesity in the vasculature and targets for DPP-4i (2014, NA)
• Simplified Wnt/Beta-catenin pathway (2014, NA)
• Signaling pathway regulation in human schwannomas (2014, NA)
• Insulin, CCAAT/Enhancer-Binding Proteins and Lactate Regulate the Human 11Beta-Hydroxysteroid Dehydrogenase Type 2 Gene Expression in Colon Cancer Cell Lines (2014, NA)
• Simplified phosphorylation-mediated regulation of the core Wnt/Beta-catenin pathway components (2014, NA)
• Ubiquitination-mediated regulation of the core Wnt/Beta-catenin pathway components (2014, NA)
• Coinfection of Filifactor alocis with P (2014, Porphyromonas gingivalis,Filifactor alocis)
• The gene-to-gene networks of TLR3, TLR4, and poly(I·C) in mice immunized with UV-V after SARS-CoV challenge (2014, NA)
• Network of genes in mice immunized with UV-V after SARS-CoV challenge (2014, NA)
• Major metabolites and genes contributing to the choline metabolism pathway (2014, NA)
• Canonical WNT/Beta-catenin signaling genes marked in green are hypermethylated in parous women (suggesting down-regulation of the gene in parous women) (2014, NA)
• The replication checkpoint pathway activated following DNA damage (2014, NA)
• Mechanism of bone resorption in bone marrow metastasis (2014, NA)
• Examples of potential signaling mechanisms involved in the O-glycosylation of IgA1 (2014, Homo sapiens,Mus musculus)
• Lung cell-specific modulation of LPS-induced TLR4 receptor and adaptor localization (2014, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Klebsiella pneumoniae,Haemophilus influenzae,Pseudomonas aeruginosa BL10,Mus musculus,Rattus norvegicus,Homo sapiens)
• Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study (2014, Bos taurus,Canis lupus familiaris,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Artemisia sacrorum)
• mTOR pathway and actions (2014, NA)
• Network for miRNAs involved in migration and invasion of cervical cancer cells (2014, NA)
• Cell cycle regulation by miRNA and their targets dysregulated in cervical cancer (2014, NA)
• mTOR-dependent pathways and inhibitors (2014, NA)
• Possible signaling of G (2014, NA)
• Toll-like receptor signalling (2014, Helicobacter pylori)
• Step forward back to (induced) fetal (2014, NA)
• Candida albicans Pathogenicity and Epithelial Immunity (2014, NA)
• Sorghum Phytochrome B Inhibits Flowering in Long Days by Activating Expression of SbPRR37 and SbGHD7, Repressors of SbEHD1, SbCN8 and SbCN12 (2014, NA)
• CXCL12 Induces Connective Tissue Growth Factor Expression in Human Lung Fibroblasts through the Rac1/ERK, JNK, and AP-1 Pathways (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Escherichia coli,Pasteurella multocida,Homo sapiens,Mus musculus,Armoracia rusticana)
• Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells (2014, NA)
• Qishenyiqi Protects Ligation-Induced Left Ventricular Remodeling by Attenuating Inflammation and Fibrosis via STAT3 and NFKB Signaling Pathway (2014, Oryctolagus cuniculus,Sus scrofa,Equus asinus,Mus musculus,Rattus norvegicus,Salvia miltiorrhiza,Engelhardia roxburghiana,Homo sapiens)
• Wnt signaling pathway (2014, NA)
• Model depicting the role of the PP1A signaling pathway in coordinating the activation of BRD4 and P-TEFb for inducible gene expression (2014, NA)
• Mechanism by which the PTEN-PI3K-AKT-MDM2 signaling axis exerts control over HIF1A degradation in cytoplasm under hypoxic conditions via the MDM2 E3 ligase and 26 S proteasome (2014, Mus musculus,Homo sapiens)
• Metabolic pathways for PA production (2014, NA)
• A healthy neuromuscular junction (NMJ) is a tripartite synapse composed of a motor neuron (MN) terminal synapsing onto a muscle fiber (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Molva molva,Capsicum pubescens)
• Vascular inflammation, NK cell/monocyte crosstalk and angiotensin II in cardiac ischemic injury (2014, NA)
• Pathways modified in OCC upon MSC contact related to adherence, migration, and invasion (2014, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Transcriptomic differences between OVCAR3 and SKOV3 and PCA after interaction with the mesenchymal cells (2014, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Host genetic factors in American cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of Brazil (2014, Leishmania braziliensis,Homo sapiens)
• Interaction network of differentially expressed miRNAs and their targets: network construction can be divided into two components: miRNA-target and target-target interaction, and candidate miRNA targets were predicted by mRDB (2014, NA)
• TRAIL-induced apoptosis (2014, NA)
• Differential dependency network presented over the KEGG] apoptosis pathway (2014, Saccharomyces cerevisiae,Olea europaea,Homo sapiens)
• Rewiring of apoptosis pathway in breast cancer patients with and without recurrence (2014, Saccharomyces cerevisiae,Olea europaea,Homo sapiens)
• Global Changes in Gene Expression of Barrett's Esophagus Compared to Normal Squamous Esophagus and Gastric Cardia Tissues (2014, Nicotiana tabacum,Candida dubliniensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori)
• Induction of short- and long-term tolerance by HLA-G (2014, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Proposed signaling pathway of Huh7 cells treated with BBP (see the text for details) (2014, NA)
• ChiBE overview (2014, NA)
• Synergistic and Antagonistic Drug Combinations Depend on Network Topology (2014, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Signal transduction and immune response in Helicobacter pylori infected gastric epithelial cells (2014, NA)
• Hypothetical positive feedback pathway necessary for tumor progression (2014, NA)
• Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages (2014, NA)
• LIF/JAK/STAT3-mediated growth inhibitory signaling in medullary thyroid cancer (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling circuit driving transformation and tumorigenesis (2014, Homo sapiens,Mus musculus,Gallus gallus,Corynebacterium phage gamma,Feline sarcoma virus)
• New molecules targeting angiogenesis and crosstalks between angiogenesis and tumor microenvironment (2014, Homo sapiens,Mus musculus)
• Schematic overview of TNF-Alpha-induced signaling pathways to activation of NFKB (a), apoptosis (b), and necroptosis (c) (2014, NA)
• An integrative overview of intracellular signaling pathways by the IL-1R, TLRs, NLRs, and CLRs upon an innate immune response to microbial infection or cell death (2014, NA)
• Roles of PGs/GAGs on the breast cancer motile phenotype (2014, NA)
• nAChRs pathway in lung cancer (2014, NA)
• Cell-proliferative signaling pathways in lung cancer cell (2014, Homo sapiens)
• Schematic cartoon of TLR signaling pathways (2014, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Listeria monocytogenes,Streptococcus pneumoniae,Mycobacterium tuberculosis variant bovis BCG,Porphyromonas gingivalis,Haemophilus influenzae,Mycobacterium tuberculosis variant bovis,Fusobacterium nucleatum,Borreliella burgdorferi,Neisseria gonorrhoeae,Salmonella enterica subsp. enterica serovar Typhi,Clostridium butyricum,Chlamydia muridarum,Shigella dysenteriae,Neisseria lactamica,Mus musculus,Rattus norvegicus,Candida dubliniensis,Aspergillus fumigatus,Homo sapiens,Respiratory syncytial virus,Triportheus paranensis)
• PPAR signaling pathway (2014, Homo sapiens)
• Antigen processing and presentation pathway (2014, Homo sapiens)
• Alpha-catenin (2014, NA)
• Targeting c-Met in melanoma (2014, NA)
• In summary, lancemaside A was able to suppress various inflammatory responses that are managed by macrophages and monocytes (2014, Codonopsis lanceolata,Homo sapiens)
• An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients (2014, Homo sapiens,Pan troglodytes,Mus musculus,NA)
• An Interferon Response Gene Signature Is Associated with the Therapeutic Response of Hepatitis C Patients (2014, Homo sapiens,Pan troglodytes,Mus musculus,NA)
• STRING analysis of pathway enrichment and interaction in the altered mRNA in rat ARDS (2014, NA)
• Integrative model of the physiogenomic adaptations in adipose and liver tissue induced by energy overfeeding during the last 45 days of pregnancy (2014, NA)
• Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Hepatitis C virus genotype 1,Euploea core,NA)
• Activation and regulation of BMP/Smad-dependent signalling (2014, NA)
• Intracellular IL-6 signal transduction is initiated by dimerization of gp130 through binding of IL-6/IL-6R (classic signalling, left panel) or IL-6/sIL-6R (trans-signalling, right panel) to gp130 (2014, NA)
• MTOR pathway as a therapeutic target (2014, NA)
• MTOR pathway is a central regulator of cellular processes (2014, NA)
• Detoxification of xenobiotic through the mercapturic acid synthesis pathway (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,clinical samples)
• Proposed model for the role of CD28, CTLA-4, CD80, and the PD-1/PD-L pathway in mice after ischemic stroke (2014, NA)
• Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Hepatitis C virus genotype 1,Euploea core,NA)
• Cerebral neovascularization in diabetes after stroke (2014, NA)
• Estrogens and growth factor signaling in breast cancer (2014, Homo sapiens)
• Beclin 1, its protein interactions and its role in autophagy (2014, NA)
• Autophagic process and some of its major regulators (2014, NA)
• MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana,Adenoviridae)
• Frizzled receptors reduce inflammation (2014, NA)
• PI3K/Akt signaling pathway enhances Beta-catenin activation (2014, NA)
• Beta-Catenin is an antagonist of the NFKB pathway (2014, NA)
• Wnt/Beta-catenin pathway (2014, NA)
• The pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury (2014, NA)
• Astrocytic–Neuronal–Astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA (2014, NA)
• The degradation pathway of PLGA-based nanoparticles in cancer cell (2014, NA)
• Dihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism (2014, Zingiber officinale,Nekemias grossedentata,Erica arborea,Homo sapiens,Mus musculus,Bos taurus)
• CD44 protein-protein interaction pathways were performed by String 9.0 Web software (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Rattus norvegicus,Candida dubliniensis)
• Proposed integrated model for tissue-type plasminogen activator (tPA)- and plasminogen (Plgn)-mediated modulation of blood–brain barrier (BBB) permeability during thrombolysis in ischemic stroke (2014, NA)
• Phenylpropanoid biosynthetic pathway in Ocimum sps (2014, Ocimum,Homo sapiens)
• Receptor tyrosine kinase (RTK) signaling pathway is frequently hit by lentiviral vector (LV) integration (2014, NA)
• MicroRNA miR-150 modulates the expression of GAB1 and FOXP1 that are involved in BCR-signaling pathway in CLL B cells (2014, NA)
• Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis (2014, NA)
• Profiling of Luteal Transcriptome during Prostaglandin F2-Alpha Treatment in Buffalo Cows: Analysis of Signaling Pathways Associated with Luteolysis (2014, NA)
• PPARG Provides New Insights in a Stress Induced Premature Senescence Model (2014, NA)
• Signaling pathways of leptin and insulin in the CNS (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Papio hamadryas,Caenorhabditis elegans)
• Possible therapeutic interventions on molecular mechanism inducing necrotizing enterocolitis (2014, NA)
• Structure of the systems model of type C4 photosynthesis (2014, NA)
• Signaling pathway induced by malarial ligand during liver-stage infection (2014, NA)
• Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation (2014, NA)
• Putative inhibitory pathway of the Cp-BF-mediated anti-inflammatory response (2014, NA)
• Extracellular Matrix and Liver Disease (2014, NA)
• Reactive Oxygen and Nitrogen Species in Steatotic Hepatocytes: A Molecular Perspective on the Pathophysiology of Ischemia-Reperfusion Injury in the Fatty Liver (2014, NA)
• Multiple Model-Informed Open-Loop Control of Uncertain Intracellular Signaling Dynamics (2014, Mus musculus,Bos taurus,Oryctolagus cuniculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,synthetic gene,Euphilotes enoptes)
• The p38A as a mediator of resistance in colorectal cancer (2014, NA)
• The p38A/ERK cross-talk in colorectal cancer (2014, NA)
• The p38A involvement in colorectal cancer (2014, NA)
• Predicting Kinase Activity in Angiotensin Receptor Phosphoproteomes Based on Sequence-Motifs and Interactions (2014, NA)
• The proposed mechanism of apoptosis activation in A549 cells by 6S and its cysteine-conjugated metabolite M2 (2014, Zea mays,Diaporthe sclerotioides,Zingiber officinale,Raphanus sativus,Citrus macrophylla,Bos taurus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Klebsiella aerogenes,Cornu aspersum)
• Known Hsp70 functions used to design the biological testing of the Hsp70 inhibitors in cancer cells (2014, NA)
• The miR-203-mediated regulation network for skeletal muscle cell proliferation and differentiation (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Gallus gallus,Danio rerio,Coturnix coturnix,Homo sapiens,Mus musculus,Drosophila melanogaster,Zea mays,NA)
• Simplified schematic representation of the extrinsic and the intrinsic (mitochondrial) pathways of apoptosis and necroptosis (2014, NA)
• TGFB/Smad3-initiated inhibition of SMC apoptosis through a VEGF pathway (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Antarctothoa delta)
• Small but Powerful, the Primary Endosymbiont of Moss Bugs, Candidatus Evansia muelleri, Holds a Reduced Genome with Large Biosynthetic Capabilities (2014, Buchnera aphidicola,Candidatus Hodgkinia cicadicola,Candidatus Portiera aleyrodidarum BT-QVLC,Marchantiophyta)
• Mechanism of immune dysfunction in Huntington’s disease (2014, NA)
• Human epidermal growth receptor family members, the PI3K/Akt pathway, and targeted drugs (2014, NA)
• Partial Deletion of eNOS Gene Causes Hyperinsulinemic State, Unbalance of Cardiac Insulin Signaling Pathways and Coronary Dysfunction Independently of High Fat Diet (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Serum miRNA Signature in Moyamoya Disease (2014, NA)
• Potential roles of GPR120 and its agonists in the management of diabetes (2014, NA)
• Matricellular TSP1 via CD47 restricts NO-sGC-cGMP signaling (2014, NA)
• Proposed model for 18-5p–mediated inhibition of viral reactivation through the MAPK signal transduction pathway (2014, Homo sapiens,NA)
• The proposed intracellular signaling pathways regulated by Cx43 hemichannels in bone cells (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Angiotensin II stimulates fibronectin protein synthesis via a GBG/arachidonic acid-dependent pathway (2014, Oryctolagus cuniculus,Homo sapiens)
• Proposed model of PPY induced apoptosis in MCF-7 cells (2014, NA)
• Mechanisms of the combination CFZ and CPT-11 therapeutic effects (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Nucleolar Integrity Is Required for the Maintenance of Long-Term Synaptic Plasticity (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Carassius auratus,Galaxias sp. southern,Homo sapiens,Drosophila melanogaster)
• Fluorosed Mouse Ameloblasts Have Increased SATB1 Retention and GAq Activity (2014, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Capreolus capreolus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Armoracia rusticana)
• Nucleotide excision repair (NER): the proteins associated with human diseases are highlighted (2014, Mus musculus,Cricetulus griseus,Homo sapiens,Nicotiana tabacum)
• CWC spine signaling pathways (2014, NA)
• Comparison between recombinant Shh- and EVsShh+-activated pathways modulating angiogenesis and apoptosis in endothelial cells (2014, Homo sapiens,Mus musculus,Sus scrofa)
• RB/E2F pathway (2014, NA)
• The CNS-immune system crosstalk (2014, NA)
• Immune activation-related modules differentially correlated in NSCLC (2014, Saccharomyces cerevisiae,Arabidopsis thaliana,Solanum lycopersicum,Homo sapiens,Mus musculus)
• Signaling pathway of chemoattractant GPCRs (2014, NA)
• Interleukin-1/Toll-Like Receptor-Induced Nuclear Factor Kappa B Signaling Participates in Intima Hyperplasia after Carotid Artery Balloon Injury in Goto-Kakizaki Rats: A Potential Target Therapy Pathway (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Armoracia rusticana,Moloney murine leukemia virus)
• M1 and M2 macrophage polarization (2014, NA)
• Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis (2014, NA)
• Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis (2014, NA)
• Involvement of the Janus Kinase/Signal Transducer and Activator of Transcription Signaling Pathway in Multiple Sclerosis and the Animal Model of Experimental Autoimmune Encephalomyelitis (2014, NA)
• Simplified schematic showing the proposed mechanism of how SEs may suppress cellular immunity and antitumor responses (2014, NA)
• p53 at the crossroads of MPN treatment (2014, Homo sapiens)
• Pathophysiology of Lung Injury Induced by Common Bile Duct Ligation in Mice (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Sequoia sempervirens,Spleen focus-forming virus)
• Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism (2014, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Armoracia rusticana)
• TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in ABeta-Expressing Caenorhabditis elegans (2014, NA)
• Macrophage-Activating Lipopeptide-2 Requires Mal and PI3K for Efficient Induction of Heme Oxygenase-1 (2014, NA)
• Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health (2014, NA)
• Novel Bioassay for the Discovery of Inhibitors of the 2-C-Methyl-D-erythritol 4-Phosphate (MEP) and Terpenoid Pathways Leading to Carotenoid Biosynthesis (2014, Arabidopsis thaliana,Zea mays,Embryophyta,Hordeum vulgare,PX clade,Spinacia oleracea,Ginkgo biloba,Catharanthus roseus,Gossypium hirsutum,Carthamus tinctorius,Panicum miliaceum,Mimosa pudica,Ipomoea lacunosa,Cuscuta campestris,Erigeron canadensis,Echinochloa phyllopogon,Homo sapiens,Escherichia coli)
• Genome-Wide Analysis in Human Colorectal Cancer Cells Reveals Ischemia-Mediated Expression of Motility Genes via DNA Hypomethylation (2014, NA)
• Anabolic reaction sequences in chloroplasts (A,B) and root plastids (C,D) of wild-type (A,C) and cue1 mutant plants (B,D) (2014, NA)
• Molecular pathways leading to cross-presentation in DCs (2014, unidentified influenza virus,Human papillomavirus type 16,Measles morbillivirus,Homo sapiens,Mus musculus)
• Signaling sub-network of E (2014, Eriocheir sinensis,Homo sapiens)
• Improving GD T cell functions by TLRs in combinatorial therapy (2014, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Human alphaherpesvirus 1,Vesicular stomatitis virus,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Gallus gallus,Candida albicans)
• Inflammation induces B cell activation (2014, NA)
• Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer (2014, NA)
• Categorically, the regulatory matrix entities segregate into two functionally distinct classes, activators (decorin, collagen VI, kringle 5, and endostatin) and inhibitor (laminin A2) (2014, NA)
• Targeting FANCD2 for therapy sensitization (2014, NA)
• Flagellar motility is a key bacterial determinant for phagocytic susceptibility of Pseudomonas aeruginosa by both murine and human phagocytes, with motile bacteria phagocytosed ∼100-fold more efficiently than nonmotile bacteria (top) (2014, Pseudomonas aeruginosa,Homo sapiens)
• Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins (2014, Homo sapiens,Danio rerio)
• Enriched signaling pathways with significant association with estrogen-relevant DEGs (2014, NA)
• Pathway analysis for H3K9me3 enriched genes in baboon SVZ cells (2014, Homo sapiens,Macaca mulatta,Papio anubis,Mus musculus,Drosophila melanogaster,Sequoia sempervirens)
• TORC2 regulation of autophagy and the GAAC response (2014, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Intracellular signalling pathways mediated by HLA class I or II antibody binding to endothelial cells (2014, NA)
• Importance of RhoGTPases in formation, characteristics, and functions of invadosomes (2014, Homo sapiens)
• Function and regulation of the Rho guanine nucleotide exchange factor Trio (2014, Mus musculus,Homo sapiens)
• Function and regulation of the Rho guanine nucleotide exchange factor Trio (2014, Mus musculus,Homo sapiens)
• Function and regulation of the Rho guanine nucleotide exchange factor Trio (2014, Mus musculus,Homo sapiens)
• Pathway analysis (2014, NA)
• Osteoclast differentiation and bone resorption by Rho GTPases (2014, NA)
• PleiotRHOpic (2014, NA)
• Pigment Dispersing Factor Regulates Ecdysone Biosynthesis via Bombyx Neuropeptide G Protein Coupled Receptor-B2 in the Prothoracic Glands of Bombyx mori (2014, Bombyx mori,Homo sapiens)
• Molecular pathway of the mechano-induction of tenascin-C (2014, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Transcriptional activity of FOXO1 is regulated in a multilayered manner (2014, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Stiffness-Activated GEF-H1 Expression Exacerbates LPS-Induced Lung Inflammation (2014, Homo sapiens,Mus musculus,Escherichia coli O55)
• Canonical Wnt signalling (2014, NA)
• The Sprouty-mediated regulation of cell proliferation, differentiation, and survival irrespective of the Sprouty isoform and cell type (2014, NA)
• Representative regulators of the Sprouty cellular content at transcriptional and post-translational level irrespective of the Sprouty isoform and cell type (2014, NA)
• Myeloid differentiation primary-response protein 88 (MyD88)-dependent and MyD88-independent TLR-4 signaling pathway (2014, NA)
• Ubiquitin-proteasome system maintains the balance between quiescence, self-renewal, and differentiation of HSCs.(A) The E3 ligases Itch, SCFFbxw7,CBL and SCFSkp2 maintain the quiescence of the HSC by targeting Notch, c-Myc, and STAT5, among others (2014, NA)
• Schematic overview presenting the role of RasGRP3 in mediating the Ras signaling pathways in breast carcinoma cells (2014, Bos taurus,Armoracia rusticana,Canis lupus familiaris,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• Hedgehog signalling at a glance (2014, Chlamydomonas reinhardtii)
• Ubiquitylation maintains the equilibrium between differentiation and transformation in adult stem cells (2014, NA)
• Development of hepatic and secondary systemic insulin resistance in DIO (2014, NA)
• Endoplasmatic reticulum stress caused by saturated free fatty acids (2014, NA)
• Biological cascade of BRAFV600E activation and cell cycle implications (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Plasmodium berghei,Pollachius pollachius)
• Cancer related pathways and processes that input into the Hippo pathway (2014, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• The core Hippo signaling pathway in Drosophila and humans (2014, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Insulin-like growth factor pathway (2014, NA)
• Partial model for the control of melatonin (MEL) secretion in pinealocytes (2014, NA)
• Regulation ofsome key oncoproteins and tumor suppressors on glycolysis and PPP (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• The PPP and glycolysis is shown (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• Prostate smooth muscle contraction and assumed connections to the regulation of prostate growth (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Clostridium botulinum)
• Crosstalk between mechanistic target of rapamycin signaling pathway and colorectal oncogenic pathways (2014, NA)
• De novo serine biosynthesis diverges from glycolysis (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Human papillomavirus type 16)
• An example of a CN: the EGF signaling pathway includes > 60 proteins and has several alternative pathways (from http://www.sabiosciences.com/pathwaycentral.php, where many other networks are also shown) (2014, NA)
• Two-step model for OR-instructed axonal projection of OSNs (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• PI3K pathway in different breast cancer subtypes (2014, NA)
• Glycolysis and the triacylglycerol biosynthetic pathway in Cp0710 (2014, Saccharomyces cerevisiae,Arabidopsis thaliana,Solanum lycopersicum,Embryophyta,PX clade,Sorghum bicolor,Chlamydomonas reinhardtii,Manihot esculenta,Chlorella vulgaris,Ostreococcus tauri,Volvox carteri,Helianthus tuberosus,Chlorella variabilis,Auxenochlorella protothecoides,Parachlorella kessleri,prasinophyte incertae sedis,Micromonas pusilla CCMP1545,Coccomyxa subellipsoidea C-169,Homo sapiens,Mus musculus,Middle East respiratory syndrome-related coronavirus,Apis mellifera,Ailuropoda melanoleuca)
• An overview of red blood cell metabolic pathways, including the Emden Meyerhoff glycolytic pathway, the pentose phosphate pathway (PPP), the purine salvage pathway (PSP), and GSH homeostasis (2014, NA)
• Cranberry Extract Standardized for Proanthocyanidins Promotes the Immune Response of Caenorhabditis elegans to Vibrio cholerae through the p38 MAPK Pathway and HSF-1 (2014, Vibrio cholerae,Caenorhabditis elegans,Homo sapiens)
• IGF signaling pathway (2014, NA)
• Proliferating cell hypothesis: similarities between cancer cells and Plasmodium falciparum (2014, Plasmodium falciparum,Homo sapiens)
• GeneGo graphic representation illustrates Transcription Androgen Receptor (AR) nuclear signaling (2014, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Citrus medica,Homo sapiens,Pseudomonas aeruginosa)
• In silico network and pathway enrichment analysis (2014, Homo sapiens)
• Proposed mechanism of action of the erythroid regulator ERFE (2014, NA)
• Model of ER stress-associated inflammation (2014, Homo sapiens,Mus musculus,Francisella tularensis,NA)
• Signaling pathways in follicular cells are shown (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cellular origin of thyroid carcinomas is shown (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Tolerogenic properties of plasmacytoid dendritic cells (pDCs) (2014, Human betaherpesvirus 5,Spleen focus-forming virus,Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG,NA)
• Proinflammatory properties of plasmacytoid dendritic cells (pDCs) (2014, Human betaherpesvirus 5,Spleen focus-forming virus,Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG,NA)
• Hypoxia inducible factor and VEGF link the HIF/VHL and PI3K/Akt/mTOR signaling pathways (2014, NA)
• Hypothesized model of molecular signaling underlying the reconsolidation of cocaine-related contextual memory (2014, NA)
• Proposed mechanism (2014, NA)
• Platelet thromboxane (11-dehydro-Thromboxane B2) and aspirin response in patients with diabetes and coronary artery disease (2014, Homo sapiens)
• Insulin signaling pathway and insulin insensitive (2014, NA)
• Pathogenicity of Mycobacterium tuberculosis Is Expressed by Regulating Metabolic Thresholds of the Host Macrophage (2014, Mycobacterium tuberculosis,Homo sapiens)
• Genome and Transcriptome Analysis of the Fungal Pathogen Fusarium oxysporum f. sp. cubense Causing Banana Vascular Wilt Disease (2014, NA)
• Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis (2014, Dengue virus,West Nile virus,DNA viruses,Measles morbillivirus,Sindbis virus,Chikungunya virus,Murine norovirus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Listeria monocytogenes,Matthiola incana,Francisella tularensis,Homo sapiens,Aedes albopictus)
• Mammal Notch receptors, ligands, and canonical activation pathway (2014, NA)
• Necroptosis and pyroptosis both lead to the loss of cell membrane integrity (2014, Mycobacterium tuberculosis,Homo sapiens)
• Host cell apoptosis pathways are classified into two main categories—extrinsic and intrinsic pathways (2014, Mycobacterium tuberculosis,Homo sapiens)
• HMGB1 binding to receptors and activating signal transduction pathway (2014, NA)
• Mitochondrial dysfunctions in cancer (2014, Homo sapiens,Mus musculus,NA)
• Schematic diagrams of Computational Models (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Xenopus laevis,Eucalyptus intertexta,Nucula nucleus)
• Toll-like receptors and TLR-mediated signaling pathway (2014, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis variant bovis BCG str. Sweden,Mus musculus,Rattus norvegicus,Homo sapiens,Human papillomavirus,clinical samples)
• RLR signaling pathway is shown (2014, NA)
• General interplay between the canonical TLR signaling pathway, the cytokine-mediated DNA repair feedback loop, and the growth factors-mediated signaling pathway (2014, NA)
• Illustration of the PI3K/Akt/mTOR pathway (2014, Homo sapiens)
• Group I mGluR-signaling pathway in immune cells (2014, NA)
• Neutrophil derived S100a8/S100a9 protein potentially contributing hypertensive cardiac fibrosis induced by Ang II (2014, Mus musculus,Homo sapiens)
• Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation (2014, NA)
• CsA can influence cell survival through calcineurin-dependent and calcineurin-independent pathways (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Matthiola incana,Homo sapiens,Mus musculus)
• GIV/Girdin is a central hub for pro-fibrogenic signalling networks during liver fibrosis (2014, NA)
• Different mechanisms of signaling for EMT which might be induced by FGF10 (2014, NA)
• Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells (2014, NA)
• Microarray Analysis of Cell Cycle Gene Expression in Adult Human Corneal Endothelial Cells (2014, NA)
• Hypothetical model of molecular determinants of CLL cell survival, proliferation and migration in the PB, BM and LN microenvironments (2014, Homo sapiens,Mus musculus)
• Integrins in the Trabecular Meshwork (2014, NA)
• TGFB2 and Bone Morphogenetic Proteins in the Trabecular Meshwork and Glaucoma (2014, Homo sapiens)
• Prostaglandin Analogues on Aqueous Humor Outflow Pathways (2014, NA)
• Visualized Gene Network Reveals the Novel Target Transcripts Sox2 and Pax6 of Neuronal Development in Trans-Placental Exposure to Bisphenol A (2014, NA)
• Cancer driver genes and pathways (2014, NA)
• Model depicting how PPARB/D promotes H-RAS-induced cellular senescence, whereas ER stress attenuates H-RAS-induced cellular senescence (2014, NA)
• PD-L1 expression and tumor-infiltrating lymphocytes (2014, NA)
• GPI anchorage pathway (2014, NA)
• N-glycosylation pathway (2014, NA)
• Growth hormone (GH)—insulin-like growth factor I (IGF1) pathway and its signaling cascade, which involves PI(3)K and Akt, can modulate longevity and cancer in model systems (2014, NA)
• Comparison of gene expression in immobilized relative to planktonic yeast: (A) intermediary metabolism and (B) cell cycle (2014, NA)
• Molecular Changes in Pre-Metastatic Lymph Nodes of Esophageal Cancer Patients (2014, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• RNA-seq upregulation of energy metabolism gene expression (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• ALK signaling pathway with its cross-talk with other pathways involved in the resistance to ALK-inhibitors (2014, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Production of biosynthetic precursors during glycolytic metabolism and their putative regulation during Xenopus tail appendage regeneration (2014, NA)
• H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway (2014, NA)
• Small System—High-Resolution Study of Metabolic Adaptation in the Central Metabolic Pathway to Temperate Climates in Drosophila melanogaster (2014, Drosophila melanogaster,Homo sapiens)
• Redox-Relevant Aspects of the Extracellular Matrix and Its Cellular Contacts via Integrins (2014, NA)
• Splicing regulation of the androgen receptor (AR) and phosphoinositide 3-kinase (PI3K) signaling pathways (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Diaporthe sclerotioides,Erebia epipsodea)
• GATA6 Levels Modulate Primitive Endoderm Cell Fate Choice and Timing in the Mouse Blastocyst (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Eutheria,Homo sapiens,Mus musculus,unidentified)
• Receptor tyrosine kinase (RTK) signaling in schistosome gonads (2014, NA)
• Flow diagram of the monoamine neurotransmitter biosynthesis pathway (2014, NA)
• GSK-3 as potential target for therapeutic intervention in cancer (2014, NA)
• GSK-3 as potential target for therapeutic intervention in cancer (2014, NA)
• Cytoplasmic/traditional and nuclear modes of the epidermal growth factor receptor (EGFR) signalling pathway (2014, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus,NA)
• Partial glycolytic and pentose phosphate pathway enzymes in C (2014, NA)
• UV signaling pathways within the skin (2014, NA)
• Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment (2014, NA)
• PI3K/Akt1 pathway is a downstream effector of Jak2/Stat5 signaling in luminal mammary epithelial cells (2014, NA)
• Schematized representation of biosynthetic pathway of anthocyanins in legume seeds (2014, NA)
• Signal integration following BCR engagement (2014, NA)
• Interference with type I IFN-activated JAK/STAT signaling pathway and antiviral ISGs (2014, NA)
• Interference of type I IFN production by PRRSV proteins (2014, NA)
• Vemurafenib and panitumumab combination tailored therapy in BRAF-mutated metastatic colorectal cancer (2014, Homo sapiens)
• Hypothetical model of chemoresistance in human ovarian cancer cells (2014, NA)
• Bioinformatic analyses expose alterations in nucleic acid binding and regulatory proteins (2014, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus)
• Proposed model of the protective effects of EPA against the PA-induced signaling pathway activation that leads to endothelial dysfunction (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Cereibacter sphaeroides,Solanum lyratum)
• Diagram of CD4 T cell differentiation and immunomodulation by the AhR signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa)
• Autophagic cell death in lung tumor cells (2014, Homo sapiens,Mus musculus,Arachis hypogaea,Paracentrotus lividus)
• Bioinformatics analysis by String (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Rhizobium etli)
• Raf transactivation (2014, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Proposed model for signaling pathways affected by UTD2 in breast cancer cells (2014, NA)
• Gene Expression Profiling of the Response to Interferon Beta in Epstein-Barr-Transformed and Primary B Cells of Patients with Multiple Sclerosis (2014, Mus musculus,Cricetus cricetus,Homo sapiens,Human gammaherpesvirus 4,unidentified,Venustaconcha ellipsiformis)
• Signaling pathways for LTM formation upon associative olfactory conditioning of honeybees (2014, Drosophila melanogaster,Apis mellifera,Lymnaea stagnalis,Gryllus bimaculatus,Agaricus bisporus,Brassica napus subsp. rapifera,Homo sapiens,Mus musculus)
• Insulin signaling pathway (2014, Mus musculus,Rattus norvegicus,Sus scrofa,Equus caballus,Homo sapiens)
• Expressional regulation of genes linked to immunity & programmed development in human early placental villi (2014, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Eucalyptus intertexta,Homo sapiens,Oryctolagus cuniculus,Human papillomavirus)
• IPA metabolic interaction network of plasma metabolites having a significant correlation with polyp counts in association with aGenotypebyDietinteraction effect (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Metscape gene-compounds metabolic network views of top IPA canonical pathway and biological function/disease (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Can Transcriptomics Provide Insight into the Chemopreventive Mechanisms of Complex Mixtures of Phytochemicals in Humans? (2014, Homo sapiens,Malus domestica)
• The PI3K/Akt/mTOR pathway (2014, NA)
• Mechanism of rejection of MHCIINEG myeloma cells by Id-specific CD4+ T cells (2014, NA)
• Schematic diagram representation of some of the pathways regulated by HNF1a (2014, Homo sapiens,Mus musculus,Bikinia letestui)
• Regulation of muscle mass (2014, Homo sapiens)
• Schematic of the pathway leading to the activation of TSPO in astrocytes (2014, NA)
• TLR4 signaling pathway (2014, Citrobacter rodentium,Streptococcus sp. group A,Phocaeicola vulgatus,Salmonella enterica subsp. enterica serovar Abortusequi,Mus musculus,Rattus norvegicus,Homo sapiens,Murid betaherpesvirus 1)
• Polyamidoamine dendrimer-based gene delivery vectors (2014, Homo sapiens,Mus musculus,Human immunodeficiency virus)
• Metabolite-mediated glycolytic derepression under steady-state treatment with H2O2 (2014, Staphylococcus aureus,Pseudomonas aeruginosa,Homo sapiens)
• Biosynthetic pathways of glycerophospholipids (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Caenorhabditis elegans)
• BTC-stimulated IL-8 production and bio-behaviors of lung cancer cells (2014, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Escherichia coli)
• Metabolic engineering strategies (2014, NA)
• Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies (2014, Homo sapiens,Nicotiana tabacum,Enterovirus C)
• Overrepresentation of Glutamate Signaling in Alzheimer's Disease: Network-Based Pathway Enrichment Using Meta-Analysis of Genome-Wide Association Studies (2014, Homo sapiens,Nicotiana tabacum,Enterovirus C)
• Construction of the FB-iPSC-CM regulatory circuit (2014, NA)
• Extended model for the cyclin/Cdk network driving the mammalian cell cycle (2014, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Xenopus laevis)
• Ras and autophagy in cancer development and therapy (2014, NA)
• Canonical NFKB signaling network regulated by miRNAs (2014, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,H1N1 subtype,Human gammaherpesvirus 8,Drosophila melanogaster,Caenorhabditis elegans,Giardia intestinalis,Cryptosporidium parvum,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus,Danio rerio,Helicobacter pylori,NA)
• Routes of presentation of viral peptides on DCs (2014, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Human papillomavirus type 16,H1N1 subtype,H5N1 subtype,Measles morbillivirus,Human adenovirus 5,Dengue virus type 2,Human orthopneumovirus,Homo sapiens,Pan troglodytes,Mus musculus,NA,NA)
• Caspase activation by the extrinsic (Fas-mediated) apoptosis pathway (left) vs (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Listeria monocytogenes,unidentified influenza virus)
• NOD1 and NOD2 signaling cascades (2014, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Chlamydia trachomatis,Citrobacter rodentium,Streptomyces hygroscopicus,Influenza A virus,Human betaherpesvirus 5,Homo sapiens,Mus musculus,Nicotiana tabacum,gut metagenome,NA)
• Signaling and cross talk of the parathyroid hormone and Wnt signaling pathways in the late osteoblast (osteocyte) (2014, NA)
• Basic molecular changes underlying EMT (2014, Homo sapiens,Mus musculus,clinical samples)
• Metabolic pathways for the production of the high-value products by using Z (2014, NA)
• Antineoplastic mechanisms of action of metformin (2014, NA)
• Hypothetic model for the role of the Aldolase proteins in Wnt signaling stimulation (2014, NA)
• PD-1 in T-cell activation, exhaustion, and effector function (2014, NA)
• Activation of the DNA damage response upon CDT exposure (2014, NA)
• Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis (2014, NA)
• cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis (2014, Strongyloides stercoralis,Homo sapiens)
• Na+, K+-ATPase-mediated signal transduction (2014, NA)
• Dual opposing signaling pathways of TRAIL (2014, Homo sapiens,Helicobacter pylori,Crataegus sinaica)
• Signaling pathway of TRAIL/drug combinations (2014, Homo sapiens,Helicobacter pylori,Crataegus sinaica)
• Autophagy is involved in the initiation of hepatocarcinoma (HCC) (2014, NA)
• Nesprin Family Member ANC-1 Regulates Synapse Formation and Axon Termination by Functioning in a Pathway with RPM-1 and Beta-Catenin (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Chanodichthys dabryi,Homo sapiens,Canis lupus familiaris,Eucalyptus intertexta)
• Cell cycle arrest by CDKN2A (2014, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Nicotiana tabacum)
• Interplay of transcription factors in suppression of UV-B induced flavonol accumulation by flg22 (2014, Arabidopsis thaliana,Daucus carota,Petroselinum crispum)
• Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition (2014, NA)
• New insights toward the transcriptional engineering of proanthocyanidin biosynthesis (2014, Arabidopsis thaliana,Homo sapiens)
• Beyond toxicity (2014, Arabidopsis thaliana)
• Heat shock protein-CD91 pathway mediates tumor immunosurveillance (2014, NA)
• Top-ranked gene network (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Matthiola incana)
• Mitochondrial pathway (2014, NA)
• TLR4 intracellular signaling cascade (2014, NA)
• Proposed mechanism by which -shogaol inhibits melanin biosynthesis (2014, Armoracia rusticana,Matthiola incana,Zingiber officinale,Vitex negundo,Magnolia grandiflora,Acorus macrospadiceus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Integration of the proposed pathways by which the NTPDase5/mt-PCPH acts on the neoplastic progression (2014, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Human papillomavirus type 16,clinical samples)
• HSCARG Negatively Regulates the Cellular Antiviral RIG-I Like Receptor Signaling Pathway by Inhibiting TRAF3 Ubiquitination via Recruiting OTUB1 (2014, NA)
• Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3B Signaling Pathway (2014, NA)
• Evidence that RASSF1C Stimulation of Lung Cancer Cell Proliferation Depends on IGFBP-5 and PIWIL1 Expression Levels (2014, NA)
• Scheme of the signaling cascade of actin remodeling (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• PAR1 and PAR2 modulate TLR3-dependent expression of IFNB in CFs (2014, Adenoviridae,Coxsackievirus,Mus musculus,Homo sapiens)
• Future directions for the management of pain in osteoarthritis (2014, Mus musculus,Oryctolagus cuniculus,Canis lupus familiaris,Cavia porcellus,Homo sapiens)
• Case study of the RegPhos-discovered phosphorylation networks involved in BCR signaling pathway (2014, NA)
• Schematic model showing how the MST1 kinase domain gains motional freedom by heterodimerization with RASSF5 in the membrane environment (2014, Dipturus trachyderma,Molva molva,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Escherichia coli BL21)
• Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease (2014, Homo sapiens)
• Molecular mechanisms of diabetic kidney disease (2014, Homo sapiens)
• TGFB signalling cascade alterations that lead to prostate cancer (2014, NA)
• Schematic of the proposed function of miR-199a-5p in regulatory T cells (Treg) (2014, Homo sapiens)
• Sooner and later (2014, NA)
• JAK2 receptor signaling and activation of STAT pathway (2014, NA)
• Rapamycin and paclitaxel nanoparticles synergistically target the PI3K/Akt/mTOR pathway by suppressing feedback loop Akt phosphorylation (2014, Mus musculus,Homo sapiens)
• Summary of expression patterns of complement components in the placenta (2014, NA)
• KEGG Apoptosis pathway (2014, NA)
• KEGG Cell-cycle pathway (2014, NA)
• KEGG MAPK signalling pathway (2014, NA)
• Physiological and physiopathological UPR activated pathways in B cells (2014, NA)
• Summary of the miRNAs and the TGFB pathway involved in HSCs (2014, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Adeno-associated virus,Homo sapiens)
• Summary of the miRNAs and the VEGF pathway involved in HSCs (2014, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Adeno-associated virus,Homo sapiens)
• Vpr induces G2/M arrest through activation of the SLX4 complex (2014, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Human T-cell leukemia virus type I,Sole virus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• Control of the TRAF6 signalosome by miR-146a (2014, NA)
• Schematic illustrating NLR attenuation of canonical and non-canonical NFKB signaling (2014, NA)
• Proposed schematic models for the role of different lncRNAs (green) in neural development (2014, Eutheria,Metatheria,Homo sapiens,Mus musculus,Plasmid pTF1)
• Spermatogenesis ROS endocrine gene transcriptional regulation (2014, NA)
• Opposing TNFA/IL-1Beta- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation (2014, NA)
• The pathway of TH-mediated cell motility (2014, NA)
• Resveratrol on protein phosphorylation in the insulin signaling pathway and the mTOR pathway of obese mice (2014, NA)
• Proposed signal pathway (2014, NA)
• Scheme of ErbB dimers related MAPK and PI3K pathway activation (2014, NA)
• Stochasticity of Intranuclear Biochemical Reaction Processes Controls the Final Decision of Cell Fate Associated with DNA Damage (2014, NA)
• Classification of resistance mechanisms to BRAF inhibitors (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• TGFB Signaling in Wound Epithelialization (2014, NA)
• Deregulated focal adhesion pathway in NSCLC cell lines (2014, Homo sapiens,Mus musculus,Bos taurus,Fasciola hepatica)
• NLRP3 inflammasome regulates the caspase-1 dependent maturation and secretion of pro-inflammatory cytokines (2014, Homo sapiens,Mus musculus,Influenza A virus,Vasconcellea candicans)
• Melanoma NOS1 expression promotes dysfunctional IFN signaling (2014, Homo sapiens)
• Iron Homeostasis in Peripheral Nervous System, Still a Black Box? (2014, NA)
• Positive feedback in cardioprotection: Can more mechanism lead to translation? (2014, NA)
• Targets in T-ALL: PI3K/AKT/mTOR, cyclin D3:CDK4/6, BRD4/MYC (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Regulation of protein trafficking, receptor signaling, and protein clearance by ubiquitination in Alzheimer's disease (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Thermoplasma acidophilum)
• ELF4 in type I IFN signaling (2014, West Nile virus)
• Diagrammatic presentation of regulation of Keap1-Nrf2-ARE pathway (2014, NA)
• SphK1/S1P/S1PR1 feed-forward loop sustain signals promoting colon tumorigenesis.Notes: SphK1 produces S1P, which is kept in the cell and/or is exported in the extracellular milieu (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces cerevisiae SK1,Homo sapiens)
• The S1P axis in adaptive immunity.Notes: Dietary or bacterial S1P from the intestinal lumen bind to S1PRs and activate the STAT3 pathway in intestinal epithelial cells (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces cerevisiae SK1,Homo sapiens)
• The TGFB signaling pathway (2014, NA)
• Transcriptional regulation of fat metabolism and mitochondrial biogenesis via AMPK-PGC-1A–mediated pathway (2014, NA)
• Summary of molecular mechanisms involved in pulmonary remodeling (2014, NA)
• Nck proteins as the newly identified adaptors between the BCR complex and BCAP/PI3K/Akt pathway (2014, NA)
• IL-33/ST2 signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Theilers encephalomyelitis virus)
• Targets of Twist proteins in the DNA damage response pathway (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Genes directly related to dopamine functioning (2014, NA)
• The regulation of TNF-receptor–mediated apoptosis pathway induced by AGP (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human immunodeficiency virus 1)
• Proposed renal protection mechanisms of volatile anesthetics (2014, NA)
• Proposed cascade of the mechanisms involved in PAF production by extracellular EGF in ovarian cancer cells (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Corynephage beta)
• Proteins involved in the BCR signaling pathways (2014, Homo sapiens)
• Signals derived from non-intestinal epithelial tissues control intestinal homeostasis in Drosophila (2014, NA)
• Calcium-calmodulin dependent protein kinase IV (CaMKIV), Mitogen-activated protein kinase (MAPK) and Protein Phosphatase 1 (PP1) (2014, NA)
• ZZ primary bronchial epithelial cells show an enhanced inflammatory response dependent of the ERK/EGFR/ADAM17 pathway (2014, Homo sapiens,Bos taurus,Helicobacter pylori)
• Exploiting sulphur-carrier proteins from primary metabolism for 2-thiosugar biosynthesis (2014, NA)
• Rohmer’s synthesis of ME from 3-methylfuran-2(5H)-one or citraconic anhydride (2014, Nicotiana tabacum,Diaporthe sclerotioides,Embryophyta,PX clade,Cinnamomum camphora,Botryococcus braunii,Escherichia coli,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Rhodobacter capsulatus,Homo sapiens,Sus scrofa,Triportheus paranensis)
• Mechanism of PMN recruitment and PMN transmigration (2014, NA)
• Modification of the Nrf-2 and NFKB signaling pathways by phytochemicals upregulates antioxidant and detoxification enzymes and suppresses inflammation (2014, Homo sapiens)
• Protective role and partial mechanism of peroxisome proliferator-activated receptor A in alcoholic liver disease (2014, NA)
• Signaling pathways regulating hepatic stellate cell activation in alcoholic liver disease (2014, Homo sapiens)
• Nuclear export of hepatitis B virus mRNAs (2014, NA)
• IGF signaling pathway (2014, Homo sapiens)
• Proposed mechanisms of anticancer activity of digoxin (2014, NA)
• Proposed mechanisms of anticancer activity of nelfinavir (2014, NA)
• miR-143/145 modulate signaling through the Ras-MAPK pathway (2014, NA)
• Hypothetical model for H2O2-induced signalling pathway in promoting human UCB-MSCs motility (2014, NA)
• ‘synthetic lethal addiction’ to rationalize selective synergy of PI103 and Ku-0063794 in PIK3CA mutant cells cultured in LG conditions (2014, NA)
• Pre-exposure to adenosine, acting via A2A receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles (2014, NA)
• Stage-specific expression of individual genes in Ras and Wnt pathway orchestrate cardiogenesis (2014, Homo sapiens,Mus musculus)
• Rho GTPase signaling pathway represents a convergent approach to targeting fibrosis (2014, NA)
• Current understanding of LPA/LPA5R stimulation of NHE3 activity and mobility based on current studies and the previous reports from the laboratory of Yun and colleagues (, ) (2014, NA)
• Map of SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis (2014, Gadus morhua,Homo sapiens)
• Secretory pathway components studied in zebrafish and implicated in human diseases (2014, NA)
• CADBIOM model for the canonical TGFB pathway (2014, Homo sapiens,Drosophila melanogaster,Marmota monax)
• Key features of the phosphoinositide 3-kinase (PI3K) signaling pathway (2014, NA)
• Emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections (2014, NA)
• Autophagic structures in the regulation of MAPK phosphorylation (2014, NA)
• Selective autophagy against membranous compartments (2014, NA)
• Molecular pathway analysis of regulated membrane protein changes in RLSCs as they undergo hepatocytic differentiation (2014, NA)
• Upstream regulator analysis of membrane protein changes in differently regulated proteins involved in cell-to-cell signaling and interaction (2014, NA)
• Generation and reduction of reactive oxygen species (2014, NA)
• Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014, NA)
• Schematic drawing of the current model for the interrelationship between nutrient and light signaling in T (2014, NA)
• Molecular mechanisms of hepcidin regulation (2014, NA)
• Typical PDA cell is depicted showing schematics of representative metabolic pathways that are altered in the disease in response to oncogenic Kras (2014, NA)
• Diagram depicting the role of GPX7 in regulating inflammation in esophageal epithelial cells (2014, NA)
• CDK4/6 is downstream of multiple pathways (2014, Homo sapiens,Mus musculus)
• Reciprocal inactivation of the retinoblastoma tumor suppressor pathway in cancer (2014, Homo sapiens,Mus musculus)
• GW1516 intervention inhibits progression of hepatic steatosis in mice (2014, NA)
• Paradoxical activation of the MAPK pathway.Notes: (A) Constitutively upregulated MAPK signaling by monomeric mutant BRAF (BRAFV600) is blocked by BRAF-specific inhibition using a selective BRAF inhibitor such as vemurafenib or dabrafenib (2014, NA)
• (Left): Regulation of apoptosis pathway by family of BCL-2 proteins (2014, NA)
• Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood (2014, NA)
• Signaling pathways induced by IL-17F (2014, Lareunionomyces loeiensis,Aspergillus oryzae,Homo sapiens,Mus musculus,Escherichia coli,Saimiriine gammaherpesvirus 2)
• Signaling pathways altered by MVNP and mutant p62 (2014, Respiratory syncytial virus,Measles morbillivirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Canis lupus familiaris,NA)
• Ingenuity network analysis of differentially regulated labeled-pairs (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Sequoia sempervirens,Porzana carolina)
• Simplified schema showing how genes might affect clinical responses to targeted therapies (2014, NA)
• Multiple intracellular signal transduction pathways are activated by GH (2014, Homo sapiens,Mus musculus)
• The signaling cascade activated by leptin, leading to excitatory synapse formation in hippocampal neurons (2014, NA)
• Molecular targets based on the predominant PI3K/AKT/GSK-3B pathway (2014, Curcuma longa,Citrus limon,Coptis chinensis,Salvia officinalis,Melissa officinalis,Achyranthes bidentata,Phyllanthus niruri,Anthriscus sylvestris,Mus musculus,Rattus norvegicus,Homo sapiens)
• PI3K/AKT/GSK-3B signaling pathway in neuronal cells of Alzheimer’s disease (2014, Curcuma longa,Citrus limon,Coptis chinensis,Salvia officinalis,Melissa officinalis,Achyranthes bidentata,Phyllanthus niruri,Anthriscus sylvestris,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed schematic flow of OA's role in attenuating hepatic IR injury (2014, Mycobacterium tuberculosis variant bovis,Francisella tularensis,Francisella tularensis subsp. novicida,Mycobacterium tuberculosis variant bovis BCG str. China,Mus musculus,Rattus norvegicus,Armoracia rusticana,Cavia porcellus,Ilex paraguariensis,Aralia cordata,Homo sapiens,Oryctolagus cuniculus)
• Among mechanisms involved in bone loss, proinflammatory cytokines play a major role in explaining hyper-osteoclastosis (2014, NA)
• Schematic model of Lgl/aPKC function in Hippo signalling (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Danio rerio)
• Gene network of T-ALL (early response) derived from GeneMANIA (a) and STRING (b) (NR3C1 interaction is highlighted) (2014, NA)
• Intracellular signaling pathways for hepcidin expression (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Danio rerio,Macaca fascicularis,Dipnomorpha,Saccharomyces cerevisiae,Brucella abortus)
• p58IPK and UPR-associated inflammatory signaling pathways (2014, NA)
• The mechanisms underlying the control of lipid metabolism by iodothyronines in the hepatic cell: A summary of the possible signaling pathways involved in iodothyronine actions is presented (2014, NA)
• Hepatic fibrogenesis (2014, NA)
• Hereditary leiomyomatosis and renal cell carcinoma (2014, Homo sapiens)
• Synergistic Apoptosis-Inducing Effects on A375 Human Melanoma Cells of Natural Borneol and Curcumin (2014, NA)
• Schematic description of the signaling pathways known to be activated by CCK1R and CCK2R (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• BRAF inhibitor pathway (2014, Homo sapiens,Diaporthe sclerotioides)
• Unexpected Benefits of Intermittent Hypoxia: Enhanced Respiratory and Nonrespiratory Motor Function (2014, NA)
• Hypothetical mechanism of C60(OH)24-mediated cell protection from H2O2 (2014, Mus musculus,Rattus norvegicus,Bos taurus,Armoracia rusticana,Capra hircus,Sesamum indicum,Homo sapiens)
• Oxalate: Ingenuity Pathway Analysis of the IL2-R pathway (2014, NA)
• Conceptual flow diagram (based on the data presented herein) depicting mechanistic link between p38 MAPK and IL-R signaling pathway activated by oxalate in HK-2 cells (2014, NA)
• The changes that are induced in cells by a deficiency of RPs (2014, Saccharomyces cerevisiae,Armoracia rusticana,Diaporthe sclerotioides,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Integrative Identification of Deregulated MiRNA/TF-Mediated Gene Regulatory Loops and Networks in Prostate Cancer (2014, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• Hijacking of Host Cellular Functions by an Intracellular Parasite, the Microsporidian Anncaliia algerae (2014, Anncaliia algerae,Homo sapiens)
• Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway (2014, Homo sapiens,Lareunionomyces loeiensis)
• Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway (2014, Homo sapiens,Lareunionomyces loeiensis)
• Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway (2014, Homo sapiens,Lareunionomyces loeiensis)
• VPA Alleviates Neurological Deficits and Restores Gene Expression in a Mouse Model of Rett Syndrome (2014, Homo sapiens,Mus musculus)
• MicroRNAs (miRNAs) are involved in pathogenesis of multiple myeloma (MM) by targeting some signaling pathways in myeloma cells (2014, Homo sapiens,Mus musculus)
• TGFB canonical signaling pathway (2014, NA)
• Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis (2014, NA)
• p38 MAPK isoforms for drug resistance (2014, NA)
• Depiction of the systematic procedure to study drug resistance in MM (2014, NA)
• Possible pathogenic pathways of sIBM – multifactorial mechanisms involved (2014, NA)
• The primary mechanisms through which vitamin D-regulated dendritic cells (DCs) and T-lymphocyte function.Notes: vitamin D precursors can be further processed to their active metabolite, 1,25(OH)2D3, in DCs and T lymphocytes (2014, NA)
• TLRs and autophagy (2014, NA)
• Rho protein GTPases and their interactions with NFKB: crossroads of inflammation and matrix biology (2014, NA)
• Immune responses induced by lactic acid bacteria (2014, Homo sapiens)
• Mechanisms of action of lactic acid bacteria via extrinsic and intrinsic pathways of apoptosis (2014, Homo sapiens)
• Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (HIF-1B): Is It a Rare Exception? (2014, NA)
• IL-18 signaling (2014, Homo sapiens)
• Pathophysiology of anthrax illustrated as a series of steps (2014, NA)
• Correction: De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response (2014, NA)
• Open Reading Frame 3 of Genotype 1 Hepatitis E Virus Inhibits Nuclear FactorKappa B Signaling Induced by Tumor Necrosis FactorA in Human A549 Lung Epithelial Cells (2014, NA)
• Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells (2014, Saccharomyces cerevisiae,Venustaconcha ellipsiformis,Vasconcellea candicans,Antarctothoa delta,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human papillomavirus)
• Nrf2-mediated oxidative stress response pathway is altered at multiple levels by DNA methylation in COPD airways (2014, NA)
• Simplifed MAPK signaling (2014, NA)
• LM infection in microglia (2014, Listeria monocytogenes,Homo sapiens)
• Consequences of EMT on innate signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Respiratory syncytial virus)
• Signaling pathways involved in microglial phagocytosis (2014, NA)
• ERK shuttling between the nucleus and cytoplasm regulates myogenesis (2014, NA)
• The Hippo pathway in mammals (2014, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• Molecular actions of 1,25(OH)2D3 in inflammation and energy homeostasis in adipocytes (2014, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Proposed mechanism for thrombin-stimulated glioblastoma cell proliferation (2014, Homo sapiens,Mus musculus)
• Regulation of TRN mechanosensation (2014, Caenorhabditis elegans,Homo sapiens)
• Proposed signaling pathways for dicitrinone B-induced apoptosis in A375 cells (2014, Diaporthe sclerotioides,Penicillium chrysogenum,Penicillium sp.,Saccharina japonica,Penicillium citrinum,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Apoptotic signaling pathways in normal and malignant cells (2014, Homo sapiens,Mus musculus)
• MYC autorepression and general cellular gene repression by histone modification (2014, Homo sapiens)
• The allele-specific cancer risk of rs6983267 (2014, Homo sapiens)
• Stress-signaling pathways in C (2014, Cryptococcus neoformans,Homo sapiens)
• All diabetes drugs are likely to have indirect effects in the CNS by affecting circulating concentrations of glucose and insulin (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Tupaia glis)
• NPY inhibits BAT thermogenesis via reduced SNS outflow (2014, NA)
• microRNAs in Cancer Cell Response to Ionizing Radiation (2014, NA)
• microRNAs in Cancer Cell Response to Ionizing Radiation (2014, NA)
• microRNAs in Cancer Cell Response to Ionizing Radiation (2014, NA)
• microRNAs in Cancer Cell Response to Ionizing Radiation (2014, NA)
• MAP kinase signaling in SC plasticity (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bacteroides fragilis)
• Regulation of autophagy and possible targets of the autophagy enhancer drugs (2014, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Human immunodeficiency virus 1)
• Origin and signaling pathways involved in MDSCs in sepsis (2014, NA)
• Pathway showing formation of inflammosome (2014, Homo sapiens,Meleagris gallopavo)
• Four major pathways of glucose metabolism underlying glucotoxicity (2014, Mus musculus,Rattus norvegicus,Bos taurus,Homo sapiens)
• PTEN/PI3K/Akt signaling pathway (2014, Homo sapiens)
• Simulation of Swanson's Literature-Based Discovery: Anandamide Treatment Inhibits Growth of Gastric Cancer Cells In Vitro and In Silico (2014, NA)
• Unfolded protein response illustrating the activation of PERK and increase of binding immunoglobulin protein (BiP), EIF2A-P, ATF4 and CHOP (2014, Saccharomyces cerevisiae,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Equus caballus)
• Ablation of Coactivator Med1 Switches the Cell Fate of Dental Epithelia to That Generating Hair (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• mTORC2 Phosphorylation of Akt1: A Possible Mechanism for Hydrogen Sulfide-Induced Cardioprotection (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Resistance to BRAF inhibitors: intrinsic and extrinsic mechanisms.Notes: Multiple different mechanisms have been described in resistance to BRAF inhibitors (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Rat sarcoma virus)
• Activation of the MAPK pathway through a BRAFV600E mutation.Notes: (A) Normal signaling of the BRAF pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Rat sarcoma virus)
• IL-6/JAK/STAT pathway (2014, NA)
• Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Betapolyomavirus macacae)
• Schematic summary of the photoneuroendocrine control of food intake and body weight (2014, Mus musculus,Rattus norvegicus,Capra hircus,Ovis aries,Cricetus cricetus,Mesocricetus auratus,Mustela putorius furo,Mustela lutreola,Cervus elaphus,Phodopus sungorus,Microtus arvalis,Peromyscus leucopus,Mustela erminea,Sciurus carolinensis,Spilogale gracilis,Spilogale putorius,teleost fish,Coturnix coturnix,Anas platyrhynchos,Coturnix japonica,Sturnus vulgaris,Homo sapiens,Ficus carica,NA)
• Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile (2014, NA)
• An atlas of genetic influences on human blood metabolites (2014, NA)
• Mammalian target of rapamycin signaling pathway (2014, Homo sapiens)
• MicroRNAs and Toll-like receptor signaling pathway in hepatitis B virus infection (2014, NA)
• Molecular interactions between Wnt/Beta-catenin and PPARG signaling in colorectal cancer cells (2014, NA)
• The Wnt/Beta-catenin signaling in epithelial cells (2014, NA)
• ErbB Receptors (2014, NA)
• Multiple pathways can stimulate Beta-cell replication in obesity, and there is overlap of many of the downstream activators (2014, Homo sapiens,Mus musculus)
• In vivo gut transcriptome responses to Lactobacillus rhamnosus GG and Lactobacillus acidophilus in neonatal gnotobiotic piglets (2014, NA)
• Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway (2014, Schistosoma mansoni,Homo sapiens)
• Schematic diagram showing the neuroanatomy of the kisspeptin-GnRH pathway and the relationship between KNDy neurones and GnRH neurones in humans and rodents (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Ovis aries,Theobroma cacao)
• An Expanded Notch-Delta Model Exhibiting Long-Range Patterning and Incorporating MicroRNA Regulation (2014, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Xenopus laevis,Ciona intestinalis,Homo sapiens,Mus musculus,Arabidopsis thaliana,Canis lupus familiaris)
• Lithium mimics and exacerbates Wnt/Beta-catenin signaling pathway activation (2014, Homo sapiens,Danio rerio)
• Lithium’s autophagy regulation mechanism in various neuropsychiatric diseases (2014, NA)
• Functional significance of differentially expressed miRNAs—miRNA-512-5p, 190a and 200b-3p (Ingenuity pathway analysis) (2014, Homo sapiens,Mus musculus)
• Receptors and cellular signaling pathways implicated in the antitumor effect of ANP (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Classical and non-classical pathways of androgen biosynthesis (2014, NA)
• Steroid hormone synthesis pathways in the adrenal gland and testis (2014, NA)
• Schematic view of insulin signaling pathway in adipose tissue (2014, NA)
• Pericyte physical and biochemical interactions at the NVU (2014, NA)
• A20 on LPS signaling pathway (2014, NA)
• Roles of Wnt5a in cancer metastasis- (A) promoting and (B) suppressive processes (2014, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Cisplatin-induced inflammation is mediated through multiple effectors including activation of NFkB, TNFA, and PARP (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 4,clinical samples,Citrus x paradisi)
• ATM Regulates Insulin-Like Growth Factor 1-Secretory Clusterin (IGF-1-sCLU) Expression that Protects Cells against Senescence (2014, NA)
• Abnormal Ca2+signaling in SNc DA neurons may cause mitochondrial oxidant stress, proteostasis deficits and eventual cell death (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Paracentrotus lividus,Homo sapiens,Curcuma longa)
• Working model of IRE1-XBP1 signaling pathway during coronavirus infection, using IBV as an example (2014, Influenza A virus,Coronaviridae,Human alphaherpesvirus 1,Severe acute respiratory syndrome-related coronavirus,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Vesicular stomatitis virus,West Nile virus,Japanese encephalitis virus,unidentified human coronavirus,Murine hepatitis virus,Human coronavirus 229E,Human coronavirus NL63,Human coronavirus OC43,Infectious bronchitis virus,SARS coronavirus NS-1,Murine coronavirus,Transmissible gastroenteritis virus,African swine fever virus,Tick-borne encephalitis virus,Bovine viral diarrhea virus 1,SARS coronavirus LC3,Bat SARS-like coronavirus,Macropodid alphaherpesvirus 1,Murine hepatitis virus strain S,Murine hepatitis virus strain A59,Human betacoronavirus 2c EMC2012,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Gallus gallus,Camelus dromedarius,NA)
• Flowchart showing the induction of ER stress and its physiological outcomes during coronavirus infection (2014, Influenza A virus,Coronaviridae,Human alphaherpesvirus 1,Severe acute respiratory syndrome-related coronavirus,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Vesicular stomatitis virus,West Nile virus,Japanese encephalitis virus,unidentified human coronavirus,Murine hepatitis virus,Human coronavirus 229E,Human coronavirus NL63,Human coronavirus OC43,Infectious bronchitis virus,SARS coronavirus NS-1,Murine coronavirus,Transmissible gastroenteritis virus,African swine fever virus,Tick-borne encephalitis virus,Bovine viral diarrhea virus 1,SARS coronavirus LC3,Bat SARS-like coronavirus,Macropodid alphaherpesvirus 1,Murine hepatitis virus strain S,Murine hepatitis virus strain A59,Human betacoronavirus 2c EMC2012,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Gallus gallus,Camelus dromedarius,NA)
• Schematic presentation of the OPG/RANK/RANKL/TRAF6 pathway in osteoclasts (2014, Homo sapiens,Dipturus trachyderma)
• Schematic showing the protein acetylation sites in metabolic pathways that are most differentially acetylated in LDKO/flox liver (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Carthamus tinctorius,Homotherium serum,Homo sapiens,Leptospira kmetyi)
• Role of pyruvate in neurodegeneration (2014, NA)
• Pyruvate dysmetabolism in cancer (2014, NA)
• Enzymes involved in proximal pyruvate metabolism (2014, NA)
• The main Notch pathway components (2014, Drosophila melanogaster,Homo sapiens)
• Some examples of 13C-labelling patterns in brain metabolism, based on results with singly labelled substrates () (2014, NA)
• Biosynthetic pathway of prodigiosin (2014, NA)
• Canonical catecholaminergic neuron is one that generates dopamine, noradrenaline or adrenaline (2014, Gallus gallus,Danio rerio,Xenopus laevis,Cyprinus carpio,Petromyzon marinus,Caenorhabditis elegans,Pleocyemata sp.,Hirudo medicinalis,Mus musculus,Rattus norvegicus,Homo sapiens,Felis catus)
• Scheme for GAG biosynthesis (chondroitin/dermatan and heparan sulfate synthesis and keratan sulfate synthesis pathway) (A) and degradation (B) (2014, Mycteroperca microlepis,Homo sapiens)
• Crosstalks between ghrelin and insulin signaling (2014, NA)
• Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling (2014, NA)
• Ang II signaling in mouse and human PTs (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Corynephage beta)
• Canonical Wnt pathway ] (2014, NA)
• Cysteinyl leukotriene receptor-1-independent and -dependent anti-inflammatory activities of montelukast, pranlukast, and zafirlukast (2014, NA)
• RTK/RAS/PI(3)K signaling pathway (2014, Homo sapiens,Omegavirus omega)
• In mTOR signaling pathway, there is the triplet of genes codes for proteins (orange nodes), and the pair (ATM and TP53) corresponds to interacting proteins in the cell cycle pathway (light blue nodes) (2014, Homo sapiens,Omegavirus omega)
• KLK5 protease suppresses breast cancer by repressing the mevalonate pathway (2014, Saccharomyces cerevisiae,Komagataella pastoris,Homo sapiens,Mus musculus)
• Schematic diagram (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Rattus norvegicus,Armoracia rusticana)
• Cross-talk between EpCAM signaling and the Wnt pathway (2014, NA)
• Graphical representation of two of the top score networks identified by Ingenuity Pathway Analysis (IPA) (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• TRAIL-induced extrinsic apoptotic pathway (2014, Arachis hypogaea,Curcuma longa,Morus alba,Polygonum cuspidatum,Broussonetia papyrifera,Homo sapiens,Mus musculus,Ovis aries)
• LDH-FITC nanoparticle intracellular fate (2014, NA)
• Pharmacological Preconditioning with Vitamin C Attenuates Intestinal Injury via the Induction of Heme Oxygenase-1 after Hemorrhagic Shock in Rats (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Mycobacterium tuberculosis)
• Summary of signaling events leading to PRKD2-dependent induction of senescence in p53wt and p53mut GBM cells (2014, NA)
• On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio (2014, NA)
• Schematic diagram demonstrating the effects of cytokines on signaling pathways mediating initial Ca2+-dependent contraction in colonic smooth muscle cells (2014, Mus musculus,Homo sapiens)
• Co-culture with M38 melanoma upregulate interferon signalling pathways (2014, Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens)
• Post-Transcriptional Regulation of Interferons and Their Signaling Pathways (2014, NA)
• CD28 signaling in myeloma cells (2014, Mus musculus,Homo sapiens)
• Base excision repair (BER) pathway (2014, NA)
• Resistance to anti-EGFR moAbs in mCRC (2014, Homo sapiens,Mus musculus,NA)
• Hypothetical model illustrating possible molecular mechanisms underlying the action of the glucocorticoid receptor in the excitation-inhibition balance in NPCs (2014, NA)
• An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway (2014, Hepatitis B virus,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Dengue virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Betapolyomavirus macacae,Human alphaherpesvirus 2,Shrimp white spot syndrome virus,White spot syndrome virus,Venustaconcha ellipsiformis,Penaeus vannamei,Penaeus monodon,Penaeus japonicus,Homo sapiens,Bos taurus,Armoracia rusticana,NA)
• Chromatin Remodelling Induced by the Freshwater Cyanotoxin Cylindrospermopsin in Human Intestinal Caco-2 Cells (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Cylindrospermopsis raciborskii,Umezakia natans,Homo sapiens)
• Augmenting Microarray Data with Literature-Based Knowledge to Enhance Gene Regulatory Network Inference (2014, Escherichia coli,Bacillus subtilis,Escherichia coli K-12,Homo sapiens,Saccharomyces cerevisiae)
• Scheme representing the insulin signalling pathway, the mechanisms involved in the high glucose-induced impairment of the insulin pathway and the proposed mechanism by which PPARB agonists prevent high glucose-induced insulin resistance in HUVECs (2014, Rattus norvegicus,Homo sapiens)
• Schematic diagram illustrating the possible mechanisms responsible for CORM-2 effects on LPS-induced VCAM-1 expression in RASFs (2014, NA)
• Post-Transcriptional Regulation of Interferons and Their Signaling Pathways (2014, NA)
• Distinct regulation of apoptosis pathway genes in neurons and fibroblasts in response to VZV infection (2014, Homo sapiens,Human alphaherpesvirus 3)
• Proposed regulatory mechanism of protein tyrosine phosphatases in C (2014, NA)
• Metabolic reconstruction of BiG (2014, Apis mellifera,Bombus impatiens,Bombus,Candidatus Schmidhempelia bombi)
• Proposed glycerol metabolic pathway in E (2014, NA)
• Glucose metabolism pathway (2014, Homo sapiens)
• Integrative pathway analysis (2014, NA)
• Meet the terminator: the phosphatase PP2A puts brakes on IRF-3 activation (2014, NA)
• Autophagy regulates p62/SQSTM1 levels to control multiple pro-oncogenic signaling pathways (2014, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Pathway Bridge Based Multiobjective Optimization Approach for Lurking Pathway Prediction (2014, NA)
• Based on experimental data GDS3634, miR-205 expression effect on prostate cancer cell line, from NCBI public database browser, P value of 8 samples of Student's t-test, microarray data was applied as the link cost for predicted paths (2014, NA)
• Possible mechanisms of the opioid receptor–mediated influence of morphine on tumor growth (2014, NA)
• Signaling events in murine heart development and cardiac ESC differentiation (2014, NA)
• PPI network and signaling pathway analysis (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• General overview of TLR4 signaling in humans (2014, NA)
• Cross-talk between mitochondrial metabolism and the IIS pathway is required to trigger the mitohormetic response in C (2014, NA)
• Drosophila immunity response pathways (2014, NA)
• Predicted insulin signaling pathway in schistosomes based on the characterization of schistosome insulin receptors, the published S (2014, Caenorhabditis elegans,Schistosoma mansoni,Schistosoma japonicum,Schistosoma haematobium,Schistosomatidae,Schistosoma bovis,Saccharomyces cerevisiae,Saccharomyces cerevisiae IR-2,Sedum japonicum subsp. japonicum,Homo sapiens,Mus musculus,Escherichia coli,Sus scrofa,Xenopus laevis)
• Top-ranked signaling networks related to Na+/K+/2Cl- cotransporter 1 downregulation according to ingenuity pathway analysis (2014, Homo sapiens)
• Schematic model illustrating the signaling pathway by which ANG suppresses the inflammatory response involving TBK1-mediated NFKB nuclear translocation in HCFs inflamed by TNFA (2014, NA)
• Causal BN learned from breast cancer cases for the ErbB pathway (2014, Homo sapiens,Mus musculus)
• Responses of the Insulin Signaling Pathways in the Brown Adipose Tissue of Rats following Cold Exposure (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Drosophila melanogaster,Sequoia sempervirens)
• Proposed pathway for 1 biosynthesis featuring an AT-less type I PKS and proceeding via 2 as an intermediate (2014, Streptomyces sp.,Escherichia coli,Streptomyces griseus,Streptomyces noursei,Nocardia iowensis,Streptomyces sp. YIM 56141,Homo sapiens,Diaporthe sclerotioides,NA)
• Both images were created using IPA (2014, NA)
• PPARB/D promotes HRAS-induced senescence by potentiating p-ERK and repressing p-AKT (2014, NA)
• Mitotic roles of Polo-like kinase pathway (2014, NA)
• Intracellular signal propagation of human toll-like receptors and corresponding ligands in innate immunity (2014, NA)
• Synthesis of isoprenoid compound by nonmevalonate pathway: a flow chart; (b) chemical reactions involved in biosynthesis of isoprenoid via nonmevalonate pathway (2014, NA)
• Core signaling pathways responsible for airway smooth muscle contraction (2014, NA)
• Chemical Genomic-Based Pathway Analyses for Epidermal Growth Factor-Mediated Signaling in Migrating Cancer Cells (2014, Homo sapiens,Bos taurus,Streptomyces sp.)
• Single-stranded RNA loading to AGO-clade Argonaute proteins (2014, Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Schizosaccharomyces pombe,Bombyx mori,Solanum melongena,Tetrahymena thermophila,Escherichia coli,Cereibacter sphaeroides,Aquifex aeolicus,Homo sapiens,Mus musculus,Danio rerio,Saimiriine gammaherpesvirus 2,NA,NA)
• Canonical and non-canonical pathway leading to the activation of NFKB (2014, Saccharomyces cerevisiae,Glycine max,Embryophyta,Thuja plicata,Juniperus virginiana,Mus musculus,Rattus norvegicus,Homo sapiens,prion)
• Targeting LIM kinase in cancer and neurofibromatosis (2014, NA)
• Two-step model for the pro-apoptotic actions of KCNB1 (2014, NA)
• Redox Modulation of FAK Controls Melanoma Survival - Role of NOX4 (2014, NA)
• Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development (2014, NA)
• Wnt and planar cell polarity signaling in cystic renal disease (2014, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Rho-GTPase signaling in leukocyte extravasation (2014, NA)
• CCM1 and the second life of proteins in adhesion complexes (2014, NA)
• Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384 (2014, Homo sapiens)
• Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro (2014, Homo sapiens)
• Colorectal cancer metastasis signaling pattern (2014, NA)
• How the Venom from the Ectoparasitoid Wasp Nasonia vitripennis Exhibits Anti-Inflammatory Properties on Mammalian Cell Lines (2014, NA)
• Independent control of aging and axon regeneration (2014, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response (2014, Danio rerio,teleost fish,Cyprinus carpio,Salmo salar,Ictalurus punctatus,Dicentrarchus labrax,Epinephelus coioides,Gadus morhua,Larimichthys crocea,Scophthalmus maximus,Solea senegalensis,Lateolabrax japonicus,Aeromonas hydrophila,dsRNA viruses,Aeromonas hydrophila 4AK4,Ictalurid herpesvirus 1,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Cryptocaryon irritans)
• De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaena crocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response (2014, Danio rerio,teleost fish,Cyprinus carpio,Salmo salar,Ictalurus punctatus,Dicentrarchus labrax,Epinephelus coioides,Gadus morhua,Larimichthys crocea,Scophthalmus maximus,Solea senegalensis,Lateolabrax japonicus,Aeromonas hydrophila,dsRNA viruses,Aeromonas hydrophila 4AK4,Ictalurid herpesvirus 1,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Cryptocaryon irritans)
• Oxidative Stress, Redox Signaling, and Autophagy: Cell Death Versus Survival (2014, NA)
• Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy (2014, NA)
• Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy (2014, NA)
• Fatty Acids from Membrane Lipids Become Incorporated into Lipid Bodies during Myxococcus xanthus Differentiation (2014, NA)
• B2-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through Beta-Arrestin-Dependent Signaling (2014, NA)
• Apoptosis execution phase (2014, Homo sapiens,Mus musculus)
• Schematic diagram of the inhibition of proliferation by SO2 and the pathways (2014, Bos taurus,Armoracia rusticana,Sus scrofa,Lareunionomyces loeiensis,Homo sapiens,Rattus norvegicus,NA)
• Insulin/mTOR pathway in RPE cells (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus)
• Combined metabolomics–transcriptomics identification of pathways affected by MPP+ (2014, Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Oryctolagus cuniculus)
• Metabolic feedback via HBP and N-glycan branching (2014, Mus musculus,Homo sapiens)
• Mutated and wild-type tyrosine kinase activation in cancer (2014, NA)
• Disruption of Interleukin-1B Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Pseudomonas aeruginosa,Aspergillus fumigatus,Mangifera indica,Paenibacillus macerans,Homo sapiens,Venustaconcha ellipsiformis,Argentina sphyraena)
• Beta-Adrenergic Receptor-Dependent Alterations in Murine Cardiac Transcript Expression Are Differentially Regulated by Gefitinib In Vivo (2014, NA)
• Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt/mTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages (2014, Escherichia coli,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Escherichia coli DH5alpha,Salmonella enterica,Salmonella enterica subsp. enterica serovar Typhi,Mycobacterium marinum,Helicobacter pylori SS1,Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Diaporthe sclerotioides)
• Cell cycle control in Rb1ΔG/ΔG mutant cells (2014, Mus musculus,Homo sapiens)
• Alcohol metabolism and its contribution to tissue injuryThe average rate at which alcohol is eliminated from the body is ∼7 g/h, which translates to ∼1 drink/h (2014, NA)
• Regulation of TGFB signaling by Dab2 and cholesterol (2014, NA)
• Network analysis performed on converging genes differentially regulated in response to different stresses in mouse and between different selected Flinders lines (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens,clinical samples)
• Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes (2014, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Homo sapiens)
• dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction-Dependent and Independent Effects (2014, NA)
• A Rhodopsin-Guanylyl Cyclase Gene Fusion Functions in Visual Perception in a Fungus (2014, PX clade,Chlamydomonas reinhardtii,Chlorophyta,Opisthokonta,Allomyces macrogynus,Blastocladiella emersonii,Gonapodya prolifera,Catenaria anguillulae,Allomyces reticulatus,Paracentrotus lividus,Dictyostelium discoideum,Patinopecten sp.,Salpingoeca rosetta,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Halobacterium salinarum)
• 98 proteins that showed significant changes in oxidation levels with HFHS diet were subjected to IPA (2014, Mus musculus,Homo sapiens)
• NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages (2014, NA)
• Topology of the signaling and metabolic pathway of eicosanoid production in human (2014, NA)
• Activation, signalling and targeting of ErbB receptor family members (2014, Homo sapiens,Mus musculus,clinical samples,Moolgarda engeli)
• Diverse mechanistic pathways of metformin (2014, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• CUL7-OBSL1-CCDC8 pathway and its predicted role in cell growth (2014, NA)
• Metabolic pathways with different expression profiles in and populations at 12 (2014, NA)
• Predicted mechanism of sialic acid-binding lectin (SBL)-induced apoptosis and proposed factors that influence the effects of SBL (2014, NA)
• Simplified signaling pathway for muscle hypertrophy (2014, NA)
• Glucogen‐like peptide‐1 and cancer (2014, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Hypothesis regarding the inhibitory signaling of amarogentin in platelet activation (2014, NA)
• Sites of thyroid hormone regulation of metabolism (2014, NA)
• TG2-mediated adhesion/signaling at the cell surface (2014, NA)
• Cytoskeletal proteins in cerebral cavernous malformation signaling pathways (2014, Homo sapiens,Mus musculus)
• Patterns of Gene Expression Associated with Pten Deficiency in the Developing Inner Ear (2014, NA)
• Propofol and Orexin A interfere with neurite retraction (2014, NA)
• Proteomics of Vitreous Humor of Patients with Exudative Age-Related Macular Degeneration (2014, NA)
• Proposed site of PEP7 inhibition of the AT1R-Erk1/2 signaling cascade (2014, Rattus norvegicus,Homo sapiens)
• Graphical overview of the Canonical Pathway analysis (2014, Mus musculus,Mus musculus domesticus,Homo sapiens)
• The role of epigenetics in the biology of multiple myeloma (2014, NA)
• Stress signaling pathways activated by electrophiles (2014, NA)
• Proposed model for the loss of mechanosensitivity in osteoblasts due to ASFF (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Propensity Scores for Prediction and Characterization of Bioluminescent Proteins from Sequences (2014, Homo sapiens,Mus musculus,Aequorea victoria,His2 virus)
• Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome (2014, NA)
• Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome (2014, NA)
• Systematic Pathway Enrichment Analysis of a Genome-Wide Association Study on Breast Cancer Survival Reveals an Influence of Genes Involved in Cell Adhesion and Calcium Signaling on the Patients’ Clinical Outcome (2014, NA)
• Ingenuity Pathway Analysis of genes negatively regulated by unliganded GR (2014, NA)
• Ingenuity Pathway Analysis of genes positively regulated by unliganded GR (2014, NA)
• Activation of the "Role of BRCA1 in DNA Damage Response’ pathways in NCR versus CR samples (2014, NA)
• Central metabolic pathway proteome at different growth conditions (2014, NA)
• Akt and NFKB signaling in drug resistance mechanism of tumor cells (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Citrus macrophylla)
• An Expanded Genomic Representation of the Phylum Cyanobacteria (2014, gut metagenome,metagenomes,Synechococcus elongatus PCC 6301,activated sludge metagenome,uncultured bacterium,uncultured bacterium Of10,Candidatus Obscuribacter phosphatis,Leptospirillum ferrodiazotrophum,Vampirovibrio chlorellavorus,uncultured bacterium Of25,Candidatus Gastranaerophilus,Candidatus Gastranaerophilus phascolarctosicola,Candidatus Caenarcanum bioreactoricola,uncultured bacterium mle1-12,Homo sapiens,Bos taurus,Hylobates sp.,Phascolarctos cinereus)
• Wnt pathway, sclerostin, and DKK1; effects of monoclonal antibodies on bone.(a) Scl and DKK1 bind Wnt coreceptors LRP5/6 to inhibit Wnt binding and signaling to decrease bone formation (2014, NA)
• The impact of 5q deletion upon myeloid cell fate (2014, NA)
• Heme biosynthesis (2014, NA)
• HCV apoptotic signaling pathways (2014, Hepatitis B virus,Human gammaherpesvirus 4,Bovine viral diarrhea virus 1,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,Drosophila melanogaster,Cutibacterium acnes,NA)
• An MAPK network downstream of SDF-1/CXCR4 signaling in breast CSCs (2014, Homo sapiens,Mus musculus)
• Expansion of the SDF-1/CXCR4 migratory signaling network in breast cancer stem cells (2014, NA)
• Schematic simplified demonstration of the main mechanisms supposed to be involved in fatty acid and TNF family interaction at different levels of colon epithelial cell organisation (2014, Glycine max,Candida dubliniensis,Helianthus annuus,Citrus macrophylla,Mus musculus,Rattus norvegicus,Homo sapiens,Triportheus paranensis)
• Pathophysiology of diabetic neuropathy (2014, NA)
• Upregulation of a Steroid Synthesis Pathway in Th2 Cells In Vitro(A) Schematic representation of integrated steroid biosynthesis pathway with abbreviated metabolites (black) and protein factors (blue) (2014, NA)
• Schematic overview of MBL-dependent activation of the lectin pathway of complement (2014, Escherichia coli,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Chlamydia trachomatis,Neisseria meningitidis,Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Pan troglodytes,Plasmodium falciparum,Human betaherpesvirus 5,NA)
• Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer (2014, NA)
• Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another “double hit” lymphoma with very poor outcome? (2014, Escherichia coli,Escherichia coli O55,Homo sapiens,Mus musculus)
• Circadian Redox and Metabolic Oscillations in Mammalian Systems (2014, Homo sapiens,Mus musculus)
• TLR-induced signalling pathways (2014, NA)
• Signalling pathways that were altered in the high serum group (2014, NA)
• Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses (2014, Mus musculus,Homo sapiens)
• Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus,Capra hircus,Schizosaccharomyces pombe,Nucula nucleus,Homo sapiens,Danio rerio)
• Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease (2014, Homo sapiens,Danio rerio)
• Finding Novel Molecular Connections between Developmental Processes and Disease (2014, NA)
• Simplified scheme of the N-glycosylation pathway (2014, Mus musculus,Bos taurus,Canis lupus familiaris,Equus caballus,Cricetulus griseus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Triportheus paranensis,Paracentrotus lividus)
• Transcriptome Profiling of the Theca Interna in Transition from Small to Large Antral Ovarian Follicles (2014, NA)
• Intracellular signalling pathway originating at EGFR and inducing the activation of proliferation, inhibition of apoptosis, and differentiation of epithelial and cancer cells (2014, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development (2014, NA)
• Concise review on the current understanding of pancreatic cancer stem cells (2014, NA)
• RNA-Binding Protein, ZFP36L2, Influences Ovulation and Oocyte Maturation (2014, NA)
• Complementary signaling cascade pathway inhibition of pertuzumab given in conjunction with trastuzumab (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis)
• Major molecular events by which rotenone provokes apoptosis in Jurkat cells under different glucose conditions (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Eucalyptus intertexta,Derris elliptica,Homo sapiens)
• Anti-inflammatory mechanism of IL-10 (2014, NA)
• Signaling pathway of SFRP5 (2014, NA)
• Anti-inflammatory mechanism of omentin (2014, NA)
• Proposed pathway for activation/proliferation of alloantigen-specific nTreg and comparison with the non-antigen driven proliferation of nTreg that do not have a TCR specific for the antigen (2014, NA)
• Astrocyte calcium-dependent vasoactive signaling pathways (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of POR in biosynthesis of androgens in classic and alternate pathways (2014, Homo sapiens,Mus musculus,Bacillus subtilis,Plasmodium yoelii,Metatheria)
• Key signaling pathways involved in the early recurrence/metastasis (R/M≤6months) and late recurrence/metastasis (R/M6-12months) of H-HCC (2014, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples)
• PI3K/AKT/ PTEN pathway and ROS may be involved in several diseases besides cancer and aging (2014, NA)
• PI3K/AKT/PTEN signaling, which modulate NOXs-derived ROS (2014, NA)
• Role of Heat shock protein-27 (HSP27) and clusterin (CLU) in cancer cell survival (2014, NA)
• PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (2014, Homo sapiens,Mus musculus)
• Methylcrotonyl-CoA Carboxylase Regulates Triacylglycerol Accumulation in the Model Diatom Phaeodactylum tricornutum (2014, NA)
• Proposed CXCR4–CXCR7 crosstalk affecting major signaling pathways related to cell survival, proliferation, and migration (2014, NA)
• Hypothesized model for the signal pathway involved in the ChREBP-induced lipogenesis and fibrosis in mesangial cells under high glucose (2014, NA)
• Cross-talk between Two Signaling Pathways Drives Aggressive Late-stage Breast Cancer♦ (2014, NA)
• How TAZ/YAP direct TGFBeta-induced tumorigenic events (2014, NA)
• How PLCG1 regulates USP1 phosphorylation to mediate 20E-induced gene expression for metamorphosis (2014, Helicoverpa armigera)
• Working model for Fas signaling in cancer-related inflammation and breast cancer progression (2014, Homo sapiens,Mus musculus)
• Adenylate cyclase-cAMP pathway (2014, NA)
• Crosstalk pathway (2014, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Saccharomyces cerevisiae,gut metagenome)
• Schematic diagram representing the hypothetical mechanisms of the insulin-dependent systemic (I) and insulin-independent direct (II) effects of metformin in the endometrium (2014, NA)
• Simplified eicosanoid metabolic pathway (2014, NA)
• Gene Expression Profiling Reveals Large Regulatory Switches between Succeeding Stipe Stages in Volvariella volvacea (2014, Volvariella volvacea)
• Digital Expression Profiling Identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as Potential Predictive Biomarkers for Neo-Adjuvant Chemotherapy Response in Paediatric Osteosarcoma (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Schizosaccharomyces pombe)
• Proposed pathways contributing to the maternal syndrome of preeclampsia and the mechanism of action of antioxidants, ER chaperones, NO, and H2S donors and statins (2014, NA)
• Apoptosis pathways (2014, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Rattus norvegicus,Calotropis gigantea,Scardinius erythrophthalmus)
• STAT3 and epithelial–mesenchymal transitions in carcinomas (2014, NA)
• Crosstalk between TGFB signaling and the renin-angiotensin system in fibrosis (2014, NA)
• Effects of the HIF pathway on mesenchymal stem cells (MSCs) (2014, NA)
• Inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells (2014, NA)
• Nox NADPH Oxidases and the Endoplasmic Reticulum (2014, NA)
• Role of NADPH Oxidases in Liver Fibrosis (2014, NA)
• Role of NADPH Oxidases in Liver Fibrosis (2014, NA)
• EPH receptors crosstalk with EMT-related signaling pathways (2014, NA)
• Illustration of changes in cAMP–pCREB and MAPK–SRE signaling pathways induced by agonist actions at NTR1–D2R heterodimers and at NTR1 receptor homodimers and D2 receptor homodimers (2014, Homo sapiens,Rattus norvegicus)
• Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization (2014, Homo sapiens,Rattus norvegicus)
• Representative core M3 structures that are dependent on multiple initial activities based in the ER (2014, NA)
• Synthesis of representative structures along the Golgi-centric core M1 and M2 glycan synthesis pathways (2014, NA)
• Simplified network diagram showing the involvement of JNK and p38 in the system (2014, NA)
• Cell-cell coupling in the somitogenesis clock (2014, Homo sapiens,Gallus gallus)
• Colorectal cancer MSI and CIN signaling pathways modified from KEGG database (2014, NA)
• Potential involvement of aberrant Beta-adrenergic stimulation of the GR-WNK4-NCC pathway in salt-sensitive hypertension (2014, NA)
• Insulin Analogs and Cancer: A Note of Caution (2014, NA)
• Regulation of GSK-3B activity (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Merluccius merluccius)
• Possible pathways for LRP1-mediated AB uptake (2014, NA)
• CK1 in Hippo signaling in vertebrates (2014, NA)
• CK1 in Wnt-signaling (2014, NA)
• Activation of T cells results in metabolic reprograming, which influences their proliferation, differentiation, and effector functions (2014, Homo sapiens,Mus musculus,Helicobacter pylori)
• The Cyclic GMP (cGMP) signaling pathway (2014, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus)
• Schema of PI3K/mTOR and other oncogenic signaling pathways in hematologic malignancies (2014, NA)
• Simplified scheme of the DAF-16 signalling pathway in C (2014, NA)
• VKR signaling pathways (2014, NA)
• Comparative Proteomic Analyses Provide New Insights into Low Phosphorus Stress Responses in Maize Leaves (2014, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Embryophyta,Solanum tuberosum,Triticum aestivum,Arachis hypogaea,Brassica napus,Sorghum bicolor,Helianthus annuus,Spinacia oleracea,Chlamydomonas reinhardtii,Ipomoea batatas,Beta vulgaris subsp. vulgaris,Physcomitrium patens,Oryza sativa Japonica Group,Petunia x hybrida,Candida pruni nom. inval.,Craterostigma plantagineum,Acetabularia acetabulum,Calophyllum membranaceum,Bouteloua curtipendula,Boerhavia coccinea,Parodiophyllochloa ovulifera,Saccharum hybrid cultivar SP80-3280,Bucklandiella crispipila,Miscanthus capensis,Sorghastrum nutans,Rice black streaked dwarf virus)
• Enhanced Expression of WD Repeat-Containing Protein 35 via CaMKK/AMPK Activation in Bupivacaine-Treated Neuro2a Cells (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Oak Root Response to Ectomycorrhizal Symbiosis Establishment: RNA-Seq Derived Transcript Identification and Expression Profiling (2014, NA)
• Molecular Evolution of the Yap/Yorkie Proto-Oncogene and Elucidation of Its Core Transcriptional Program (2014, NA)
• CNTF-induced gliosis in the retina after ONC and Pen1-C6DN + siCASP2 treatment (2014, NA)
• Schematic diagram showing the central role of the BMP6-HJV-SMAD signaling pathway in hepcidin regulation and the proposed interaction with other hepcidin regulators (2014, Homo sapiens,Mus musculus)
• MiRNA dependent regulation of DSB repair during cell cycle (2014, NA)
• Pattern recognition receptors in respiratory anti-viral immunity (2014, Escherichia coli,Lactiplantibacillus plantarum,Lacticaseibacillus casei,Limosilactobacillus reuteri,Lactobacillus acidophilus,Bifidobacterium longum,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Bifidobacterium breve,Lactobacillus gasseri,Lactiplantibacillus pentosus,Lacticaseibacillus rhamnosus CRL1505,Levilactobacillus brevis KB290,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,West Nile virus,Enterovirus C,Coxsackievirus,Human orthopneumovirus,Human metapneumovirus,Murine orthopneumovirus,Homo sapiens,Bos taurus,Capra hircus,Pan troglodytes,Mus musculus)
• Gene network of 32 genes with pathway level expression change and mutation via GeneMANIA (2014, NA)
• Summary of adducin signaling to desmosomes (2014, Homo sapiens)
• Summary figure of the switch from Pu.1 interaction with coactivators to corepressors caused by Runx1 deficiency (2014, NA)
• Wnt signaling pathway (2014, NA)
• Prostacyclin Analogue Beraprost Inhibits Cardiac Fibroblast Proliferation Depending on Prostacyclin Receptor Activation through a TGF Beta-Smad Signal Pathway (2014, NA)
• Role of Ferulic Acid in the Amelioration of Ionizing Radiation Induced Inflammation: A Murine Model (2014, Mus musculus,Rattus norvegicus,Oryza sativa,Triticum aestivum,Homo sapiens,Bos taurus,Dipturus trachyderma,Vibrio rumoiensis)
• Hypothesis of adolescent chronic alcohol consumption effect on SPIF gene down regulation in the dilated cardiomyopathy signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Sphingolipid pathway and basic structural units of sphingolipid biosynthesis (2014, NA)
• Metals and cholesterol implicated in AB processing and neurotoxicity (2014, NA)
• Abnormalities in IRS1 interaction in the KEGG Oxidative Phosphorylation metabolic pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Abnormalities in IRS1 interaction in the KEGG PI3K-AKT signaling pathway (PI3K-AKT) (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Predicting Response to Preoperative Chemotherapy Agents by Identifying Drug Action on Modeled MicroRNA Regulation Networks (2014, Caenorhabditis elegans,Venustaconcha ellipsiformis,Homo sapiens,Bison bison)
• RhoGEF signaling pathways involved in 3D migration (2014, Homo sapiens,Mus musculus,Danio rerio,Human gammaherpesvirus 4,Derris trifoliata)
• TGFB signaling (2014, NA)
• Possible metabolic pathway related to oxidative stress in patients with Hb H disease with iron overload (2014, Homo sapiens,Rattus norvegicus)
• Schematic diagram illustrating the feedback loop of FGF/FGFR signaling and brachyury (2014, NA)
• Non-Smad signaling in response to TGFB1 and BMP-7 (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Osphranter robustus)
• Apoptotic signalling pathways (2014, Homo sapiens,Mus musculus,Gallus gallus,NA)
• MiR-126-orchestrated regulation of pDC effector functions in lymph nodes undergoing an immune response (2014, Homo sapiens,Mus musculus,Mycobacterium tuberculosis,Candida dubliniensis,Vesicular stomatitis virus)
• Conversion of vitamin K (VK) 1 to VK2, production of dihydro-VK1, the VK cycle, and Gamma-glutamyl carboxylation (2014, NA)
• Current models for mitochondrial longevity (2014, Caenorhabditis elegans,Homo sapiens)
• Proposed working model of RGS proteins in the regulation of the Ca2+ oscillation-NFATc1 signal pathway for osteoclast (OC) differentiation (2014, Homo sapiens,Rattus norvegicus)
• ProBDNF negatively regulates GABAAR expression (2014, Rattus norvegicus,Homo sapiens)
• The debulking signature (2014, NA)
• Construction of the signaling network of cell migration regulators and their classification based on biological functions (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio,vectors)
• Intracellular trypanosomatid parasites evade the protective role of IFNG signaling by targeting essential components of the JAK-STAT pathway (2014, Trypanosoma cruzi,Homo sapiens)
• Interactions of chaperone proteins with Stat3 panel (A) and Jak2 panel (B) (2014, NA)
• Schematic illustrating -adrenergic receptor signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Escherichia coli O104H4)
• The WBA pathway in the epithelial seam stem cells (2014, Caenorhabditis elegans,Homo sapiens)
• M/E switch pathway in normal and starvation conditions (2014, NA)
• Neuroprotection by Sildenafil (2014, Rattus norvegicus,Homo sapiens)
• Chemokine signaling pathway map created based on KEGG pathways (2014, NA)
• Ingenuity Pathway Analysis (IPA) of ASS234 treatment (2014, NA)
• Resistance to targeted therapies in melanoma (2014, Homo sapiens)
• Signaling crosstalk between the mTOR complexes (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens)
• Diagram of clinically detected mechanisms of acquired resistance to anti‐EGFR antibody therapy in colorectal cancers (2014, Homo sapiens)
• Illustration of the metabolic pathways and genes that were differentially affected in siliques between B (2014, NA)
• Activation of the Notch signaling pathway (2014, NA)
• Autocrine/paracrine role of IFNs on QRFP expression in a state of obesity (2014, NA)
• Hypothetical model for IGF-I regulation of kitlga expression and its signaling mechanisms in the zebrafish follicle cells (2014, Danio rerio,Homo sapiens)
• Induction of an innate immune response to Ad-based vectors (2014, Coxsackievirus,Homo sapiens)
• Reciprocal Signaling Between Translational Control Pathways and Synaptic Proteins in Autism Spectrum Disorders (2014, Homo sapiens,Mus musculus)
• Fumarate, succinate, and (R)-2HG, respectively (2014, NA)
• Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism (2014, NA)
• Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives (2014, NA)
• Components of insulin signaling pathway and the up-regulated genes with H3K27ac- or H3K4me3-increased regions by decidualization (2014, Homo sapiens)
• Intracellular pathways of factors regulating adipogenesis, lipogenesis and lipolysis in the adipocyte (2014, NA)
• Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients (2014, Homo sapiens,Mus musculus,Caenorhabditis elegans,Lareunionomyces loeiensis)
• Signaling pathways activated in chondrocytes by fibronectin fragments (2014, NA)
• Schematic diagram outlining the novel molecular targets of CAFG leading to bone anabolic effects in osteogenic cells and fracture healing induced by BMP2/Wnt/Beta-catenin pathway (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Armoracia rusticana,Mandrillus leucophaeus,Dalbergia sissoo,Bos taurus)
• Physiopathological actions of periostin activation (2014, NA)
• Schema on the combined experimental and computational approach to characterize signaling pathway activation in HIV-associated nephropathy (2014, NA)
• Schema showing the multiple functions of FOXD1 lineage myofibroblasts in interstitial kidney disease (2014, NA)
• We used an integrated system biology approach to interrogate the islet and RpWAT transcriptome , in order to understand the molecular events underlying the impact of paternal HFD consumption (2014, NA)
• Ingenuity pathway analysis reveals an up-regulation of the NOTCH pathway in LGR5 high SW480 spheres compared to LGR5 low SW480 adherent cells (2014, NA)
• Autophagy-mediated regulation of macrophages and its applications for cancer (2014, NA)
• Autophagy-mediated regulation of macrophages and its applications for cancer (2014, NA)
• Signaling pathway by which GUTK inhibited tumor metastasis in HCC (for abstract PS01-001) (2014, NA)
• Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway (2014, NA)
• Haemodynamic flow regulates the functions of SMCs (2014, NA)
• Vascular smooth muscle cells mechanotransduction mechanisms in stretch-dependent interconnected signalling (2014, NA)
• Genotype Correlation Analysis Reveals Pathway-Based Functional Disequilibrium and Potential Epistasis in the Human Interactome (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients (2014, Homo sapiens,Nicotiana tabacum)
• Cytosolic RNA and DNA-induced type I IFN signaling pathway and its regulators (2014, NA)
• Nanosecond Pulsed Electric Fields (nsPEFs) Regulate Phenotypes of Chondrocytes through Wnt/Beta-catenin Signaling Pathway (2014, NA)
• Interaction of VHL protein with HIF and other proteins including elongin B, elongin C and CUL2 (2014, Homo sapiens)
• Biological responses leading to angiogenesis driven by the HGF–Met pathway (2014, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,vectors)
• Distribution of target proteins on the compressed ‘influenza-related pathway’ (2014, herbal medicine,Homo sapiens)
• TORC2 regulation of autophagy and the GAAC response during amino acid starvation (2014, NA)
• Proposed model for the modulation of ethanol-induced Nox2 expression by globular adiponectin and its potential role in the suppression of ethanol-induced ROS production in macrophages (2014, Mus musculus,Homo sapiens)
• Signaling mechanisms responsible for promotion of cell survival mediated by HGF–Met pathway (2014, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,vectors)
• Immune system activation pathway following injury (2014, Homo sapiens)
• Signal pathway of nicotine-induced angiogenesis via activation of nAChR in non-neuronal cells (2014, Nicotiana tabacum)
• Signaling pathways activated by FGF/FGFR (2014, Homo sapiens,Mus musculus)
• Apoptosis by HPV early proteins: A number of the interactions of viral oncoproteins with cellular proteins and their effects on apoptosis (2014, Human papillomavirus,Homo sapiens)
• Crosstalk between erythropoiesis and iron metabolism involving TGFB family member GDF11 (2014, Homo sapiens)
• Neutral AA transporters and activation of the mTORC1 signaling pathway (2014, NA)
• Signaling pathways that modulate amino acid, insulin/IGF-I, and resistance exercise–induced activation of mTORC1 signaling (2014, NA)
• Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury (2014, NA)
• Schematic diagram of the signaling of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway involved in human cancers (2014, NA)
• Schematic diagram of estrogen receptor (ER) signaling (2014, NA)
• Top Ingenuity Pathway Analysis (IPA) interactome derived from transcriptional regulators found in the Vesiclepedia database (2014, NA)
• SAPPA-mediated Akt activation and survival signaling (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Komagataella phaffii GS115,Homo sapiens,Drosophila melanogaster)
• Proposed mechanism for RSV in the regulation of mtROS homeostasis through Sirt3 signaling pathway in HUVECs (2014, Armoracia rusticana,Arachis hypogaea,Fragaria x ananassa,Vasconcellea candicans,Areca catechu,Silene chalcedonica,Homo sapiens,Mus musculus,Bos taurus)
• Concept map of the cancer metabolic rewiring (2014, NA)
• Glutamine metabolic rewiring (2014, NA)
• Summary of SIRT1 regulating the apoptotic upstream pathways within a cardiomyocyte in exercise-trained SD rats (2014, Rattus norvegicus,Homo sapiens)
• Canonical PPAR signaling pathway (2014, Mus musculus,Homo sapiens)
• Schematic structures of HGF (A) and Met (B) (2014, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,vectors)
• PI3K/Akt/mTOR signaling cascade (2014, NA)
• The Wnt/Beta-catenin signaling pathway and the regeneration therapy drug candidates discussed in the paper (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Suberites domuncula,Homo sapiens)
• The Wnt/Beta-catenin signaling pathway and the oncology-indication drug candidates discussed in the paper (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Suberites domuncula,Homo sapiens)
• Wnt/Beta-catenin signaling pathway (2014, NA)
• EGFR pathway and the model of the effect of EGFR/MEK/EGFR + MEK inhibition on the pathway in RAS‐active NSCLC cell lines (2014, Homo sapiens)
• Proposed signaling network involving mTORC2 and the p38 pathway (2014, NA)
• Retinoid metabolism and the structure of retinoid receptors (2014, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Candida dubliniensis,Homo sapiens)
• Upon SV40 infection of mesothelial cells, Tag (Large T) and tag (small t) antigens are expressed (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Betapolyomavirus macacae)
• Nicotine’s effect on immunity via the A4 nAChR signaling pathway in T cells (2014, NA)
• Prostaglandin E2 modulates F-actin stress fiber in FSS-stimulated MC3T3-E1 cells in a PKA-dependent manner (2014, NA)
• Upregulated and downregulated genes in the cell cycle pathway after expansion in serum-free medium (2014, NA)
• Genes involved in the leukocyte transendothelial migration and Toll-like receptor signaling pathways (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Model showing the vasculogenesis pathway that restores tumor vasculature after irradiation and the various inhibitors of this pathway that can improve the radiation response of the tumor (2014, NA)
• Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways (2014, Homo sapiens)
• New and emerging HDAC inhibitors for cancer treatment (2014, NA)
• TTC7A mutations disrupt intestinal epithelial apicobasal polarity (2014, NA)
• Panitumumab and epidermal growth factor receptor (EGFR) signaling pathway (2014, Homo sapiens)
• Curcumin-Protected PC12 Cells Against Glutamate-Induced Oxidative Toxicity (2014, NA)
• Many ways to inactivate the p53 pathway in cancer (2014, NA)
• MiR-503 mediates constitutive suppression of the IGF-1R pathway leading to a less aggressive glioma phenotype (2014, NA)
• Perforin: an important player in immune response (2014, Mycobacterium tuberculosis,Listeria monocytogenes,Vesicular stomatitis virus,Vaccinia virus,Homo sapiens,Mus musculus,NA)
• TLR-ligand-mediated NFKB activation (2014, Diaporthe sclerotioides,Gynostemma pentaphyllum,Sophora cassioides,Homo sapiens,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Macaca mulatta,Deinococcus radiodurans,Salmonella enterica subsp. enterica serovar Dublin)
• Main signaling pathways affected in high-grade gliomas (2014, Homo sapiens)
• Crosstalk between chondrocyte and synoviocyte (2014, Mus musculus,Rattus norvegicus,Cricetulus griseus,Oryctolagus cuniculus,Equus caballus,Homo sapiens)
• Models of EGF network and CNP/NPR2 signaling in the regulation of LH-induced ovulation (2014, Homo sapiens,Mus musculus)
• Asp and aromatic amino acid biosynthetic pathways in plants (2014, Nicotiana tabacum,Nicotiana benthamiana)
• Major metabolic effects of plastidic and PAT silencing (2014, Nicotiana tabacum,Nicotiana benthamiana)
• Proposed model for the coordinated regulation of MMP-3 transcription by IKKɛ (2014, NA)
• Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis (2014, Homo sapiens,Triticum aestivum,Pekania pennanti)
• Scheme of the signal transduction pathways that control C (2014, Candida albicans,Saccharomyces cerevisiae,Carex albicans var. albicans,Desulfitobacterium hafniense,Escherichia coli CAG4,Mycoplasma capricolum,Homo sapiens,Mus musculus,prion,Olavius algarvensis,NA)
• Biological network capturing the immune response and the metabolism of glycosaminoglycan and sphingolipid revealed from Ingenuity Pathway Analysis® (IPA®) (2014, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Sequoia sempervirens,Homo sapiens)
• Genome-wide identification of transcription factors and transcription-factor binding sites in oleaginous microalgae Nannochloropsis (2014, NA)
• Activation of μ-opioid receptor induces G-protein and Beta-arrestin-2 signaling pathways (2014, NA)
• Automatic Context-Specific Subnetwork Discovery from Large Interaction Networks (2014, Homo sapiens)
• Signaling pathway by which blue light controls chemotaxis towards nitrogen sources in C (2014, Chlamydomonas reinhardtii,Homo sapiens)
• Ischemia/ reperfusion-induced and sepsis-induced endothelial dysfunction is initiated by increased amounts of reactive oxygen species (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Cavia porcellus,Homo sapiens,Escherichia coli,Lycium barbarum)
• Proposed mechanisms by which pinocembrin suppresses TGFB1-induced epithelial-mesenchymal transition and metastasis in human Y-79 cells (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Bacillus subtilis At2)
• Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells (2014, Human gammaherpesvirus 4,Human gammaherpesvirus 8,Murid gammaherpesvirus 4,Murid herpesvirus 68,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Matthiola incana,murine stem cell retroviral vector,NA,NA)
• Biological functions regulated by miR-378 and miR-378* (2014, NA)
• Upstream nutrient signaling to mTORC1 and AMPK (2014, Homo sapiens)
• Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2 (2014, Bos taurus,Capra hircus,Homo sapiens,Rattus norvegicus)
• Human Mammospheres Secrete Hormone-Regulated Active Extracellular Vesicles (2014, NA)
• Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human (2014, Homo sapiens,Mus musculus)
• Adipocyte expresses the three BAR subtypes (2014, Homo sapiens)
• Proposed feedback loop mediated by hydrogen peroxide (H2O2) (2014, Homo sapiens,Danio rerio,Dictyostelium discoideum)
• Mechanisms involved in tubuloglomerular feedback control of renal vascular tone (2014, NA)
• Mammalian target of rapamycin (mTOR) signaling pathway regulation (2014, NA)
• Sonic Hedgehog signaling maintains proliferation/self-renewal of cerebellar progenitor cells (2014, Homo sapiens)
• Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK (2014, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Arachis hypogaea,Homo sapiens,Mus musculus)
• Genes involved in chronic kidney failure (Disease Pathway) (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Genes involved in GPCR signaling Pathway: (G protein coupled-receptors are seven-transmemebrane receptors involved in signal transduction in humans) (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Predicted co-regulation of genes in the TGFB signaling pathway targeted by upregulated miRNAs in WAT during torpor (2014, Mus musculus,Ictidomys tridecemlineatus,Callospermophilus lateralis,Urocitellus columbianus,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Microcebus murinus,Myotis lucifugus,Chrysemys picta bellii,Eucalyptus intertexta)
• Predicted co-regulation of genes in the MAPK signaling pathway targeted by downregulated miRNAs in BAT during torpor (2014, Mus musculus,Ictidomys tridecemlineatus,Callospermophilus lateralis,Urocitellus columbianus,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Microcebus murinus,Myotis lucifugus,Chrysemys picta bellii,Eucalyptus intertexta)
• Predicted co-regulation of genes in the MAPK signaling pathway targeted by the downregulated miRNAs in WAT during torpor (2014, Mus musculus,Ictidomys tridecemlineatus,Callospermophilus lateralis,Urocitellus columbianus,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Microcebus murinus,Myotis lucifugus,Chrysemys picta bellii,Eucalyptus intertexta)
• Differential expression of genes involved in MAPK signaling pathway in mouse ovaries (2014, Oryza sativa,Zea mays,Glycine max,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Morone saxatilis)
• Regulation of hepatic lipogenesis by the UDCA-AMPK-SMILE signaling pathway (2014, Mus musculus,Adenoviridae,Homo sapiens)
• De novo synthesis of steroids, oxysterols, and bile acids from cholesterol (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Interactions of the Ras/PI3K/PTEN/Akt/mTOR and Ras/Raf/MEK/ERK pathways with GSK-3 (2014, NA)
• Novel approaches of targeting signaling pathways in leukemia (2014, NA)
• Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration (2014, NA)
• Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress (2014, NA)
• Obesity versus osteoarthritis: beyond the mechanical overload (2014, NA)
• Predicted model of the immune response of Epinephelus coioides larvae to V (2014, NA)
• Mammalian Hippo signaling (2014, NA)
• Immunity in Drosophila melanogaster — from microbial recognition to whole- organism physiology (2014, NA)
• Liver responds to iron signals to regulate hepcidin production (2014, NA)
• Top genes from SNP comparative analysis (2014, NA)
• Pathway analysis on SNPs that affect gene expression and drug response (2014, NA)
• Chemotherapeutic Targeting of the Transforming Growth FactorB Pathway in Breast Cancers (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Immunity in Drosophila melanogaster — from microbial recognition to whole- organism physiology (2014, NA)
• Influence of MAP on TLR9 signaling (2014, Bos taurus,Canis lupus familiaris,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Felis catus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Mycobacterium avium subsp. paratuberculosis,Mycoplasmopsis bovis,Gallus gallus,prion,unidentified,Meleagris gallopavo,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples,Apis mellifera)
• Schematic presentation of potential signaling network of HER2-NFKB-PI3 K-Akt-STAT3 (2014, NA)
• Immunity in Drosophila melanogaster — from microbial recognition to whole- organism physiology (2014, NA)
• Pathways regulating proliferation, survival, and cell death in BL.Notes: BL is associated with chromosomal translocations that deregulate expression of the proto-oncogene c-MYC (2014, Human gammaherpesvirus 4,Human herpesvirus 4 type 1,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Cooperating mutational events in MYC-driven lymphomagenesis and novel therapeutic opportunities.Notes: Continuous MYC expression is required for BL cell survival, as demonstrated by the apoptotic effect of the MYC inhibitor 10058-F4 on BL cell lines (2014, Human gammaherpesvirus 4,Human herpesvirus 4 type 1,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Schema of structure and signaling pathway of G-CSFRI and G-CSFRIV (2014, NA)
• NLRP12-mediated inhibition of canonical NFKB and ERK signaling pathways in response to Salmonella infection (2014, Mus musculus,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens)
• Essential cell signaling pathways for prostate cancer (PCa) development and crosstalks between themThe interaction of circulating androgens (T/DHT) with AR is critical for PCa growth (2014, Homo sapiens)
• Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing (2014, Mus musculus,Rattus norvegicus,Moloney murine leukemia virus,Pteropus alecto retrovirus,Homo sapiens)
• Simplified schematic illustration of PI3K/Akt and mitogen‐activated protein kinase (MAPK) signaling pathways in thyroid cancer (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Starvation effects on insulin signaling components and JH synthesis in the CA of mosquitoes (2014, NA)
• Possible mechanisms of opioid receptor-mediated influence of morphine on tumor growth (2014, NA)
• An integrated picture for gene network of interactions between soybean and race1 of Phytophthora sojae (2014, NA)
• Signal pathways involved in renal IRI (2014, Mus musculus,Rattus norvegicus,Staphylococcus aureus,Porphyromonas gingivalis,Homo sapiens,Scutellaria baicalensis)
• Possible mechanisms of protection against IRI by GLP-1 (2014, NA)
• Schematic summary of findings (2014, NA)
• For therapeutic modulation of the UPR (2014, NA)
• Central Role of the PPARG Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition (2014, NA)
• The Th17 pathway and its involvement in psoriatic disease (2014, NA)
• PI3K/AKT pathway (2014, NA)
• Tumor metabolism provides precursors for biomacromolecule synthesis (2014, NA)
• Hypothetical model illustrating the actions of hirsutenone (HIR) and CDDP in chemoresistant OVCA (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Alnus japonica,Alnus hirsuta,Alnus hirsuta var. sibirica,Homo sapiens,Mus musculus)
• Proposed model of heme-induced stasis (2014, Mus musculus,Homo sapiens)
• The activation of the NFKB transcription factor pathway by liposaccharide (LPS), TNFA, high mobility group (HMG)B1, and polymicrobial sepsis (2014, NA)
• New Metabolomic Signature in Type-2 Diabetes Mellitus and Its Pathophysiology (2014, Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus)
• Possible signalling pathways involved in enteric neurogenesis by a 5-hydroxytryptamine 4 receptor (5-HT4R) agonist mosapride citrate (MOS) (2014, NA)
• Ephrin receptor signalling is the most significant canonical pathway in an olanzapine-treated cerebellum (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus)
• Dopamine-DARPP32 feedback in cAMP signalling is a significant canonical pathway in an olanzapine-treated hippocampus (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus)
• TWEAK/Fn14 Signaling (2014, NA)
• Targeting Cadherin-17 Inactivates Ras/Raf/MEK/ERK Signaling and Inhibits Cell Proliferation in Gastric Cancer (2014, NA)
• Interaction among differentially modulated genes in the cell cycle biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments (2014, NA)
• Noxa and cancer therapy (2014, Homo sapiens,Mus musculus,Equus asinus x Equus caballus)
• Interaction among differentially modulated genes in the apoptosis biochemical pathway, using KEGG, after hgf-FNDF-LC50 and SCFA-LC50 treatments (2014, NA)
• Significantly altered pathway in primary tumor (2014, Homo sapiens,Mus musculus,Hepatitis B virus,Pekania pennanti)
• AVP-dependent signaling pathways in myogenic cells (2014, NA)
• Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis (2014, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• Alterations in the PTHrP→PTHR1→PKA pathway in osteosarcoma (2014, NA)
• Endothelial-specific loss of GRK2 impairs maturation and vascular remodeling in adult and developmental angiogenesis (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Zerumbone-loaded nanostructured lipid carrier induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line (2014, Armoracia rusticana,Zingiber officinale,Zingiber zerumbet,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Neural Epidermal Growth Factor-Like Like Protein 2 (NELL2) Promotes Aggregation of Embryonic Carcinoma P19 Cells by Inducing N-Cadherin Expression (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana,vectors)
• Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling (2014, NA)
• Complement activation pathways (2014, NA)
• Schematic diagram as summary of the present investigation (2014, NA)
• Genome Wide Expression Analysis Suggests Perturbation of Vascular Homeostasis during High Altitude Pulmonary Edema (2014, NA)
• Interactions between ERA36 and EGFR in mitogenic signaling (2014, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens)
• MiR-148b in the mTOR signalling pathway (2014, Homo sapiens)
• MiR-15a in the AD pathway (2014, Homo sapiens)
• Radiation-Induced Bystander Response: Mechanism and Clinical Implications (2014, NA)
• Radiation-Induced Bystander Response: Mechanism and Clinical Implications (2014, NA)
• Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFBeta-Activated Kinase 1 Tyrosine Phosphorylation and NFKB Signaling in Multiple Myeloma and Bladder Cancer (2014, Saccharomyces cerevisiae,Cladophora subtilissima,Lobariella angustata,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG)
• Signaling pathways involved in CTGF-induced VEGF expression and angiogenesis in human synovial fibroblasts (2014, Bos taurus,Oryctolagus cuniculus,Equus asinus,Cervus elaphus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Proposed biosynthetic pathway of hypothemycin (4) (2014, NA)
• Dopamine biosynthesis and degradation and the genes coding key enzymes (2014, NA)
• ROR1 signaling pathway (2014, NA)
• In normal tissue repair NF2 activates the Hippo pathway, an essential regulator of cell proliferation (2014, NA)
• Physiological changes with aging () (2014, Homo sapiens)
• Tumor cell ligands recognized by human GD T cells (2014, Homo sapiens)
• Putative target genes of miRNAs participating in the MAPK signaling pathway via DAVID KEGG analysis (2014, Bos taurus,Sus scrofa,Sus scrofa domesticus,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,NA)
• Noncoding RNAs in DNA Repair and Genome Integrity (2014, NA)
• Noncoding RNAs in DNA Repair and Genome Integrity (2014, NA)
• Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice (2014, Mus musculus,Homo sapiens)
• Shared pathway/ GO categories for DEGs from liver and skeletal muscle tissues (2014, NA)
• Mining Gene Expression Data for Pollutants (Dioxin, Toluene, Formaldehyde) and Low Dose of Gamma-Irradiation (2014, Drosophila melanogaster,Caenorhabditis elegans,Anopheles gambiae,Tribolium castaneum,Locusta migratoria,Daphnia pulex,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Saccharomyces cerevisiae,Dipturus trachyderma,cellular organisms)
• Influence of liver-specific glucokinase knockout on the myocardium (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• TWEAK/Fn14 signaling cascade (2014, NA)
• Consequences of coordinate activation of RHOA and ROCK1 by HIFs (2014, Rattus norvegicus,Homo sapiens)
• Cofilin regulating actin dynamics and initiating HSV-1 entry (2014, NA)
• Ingenuity pathways analysis (2014, NA)
• Interleukin-17 (IL-17) and IL-17 receptor family members and their biological roles (2014, Homo sapiens)
• Possible orexinergic mechanisms in synaptic signalling (2014, NA)
• LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NFKB and BMP/Smad Signaling (2014, NA)
• Antigenic stimulation of the BCR recruits CD79a and CD79b, and activates SYK and LYN kinase, resulting in the phosphorylation of cytoplasmic ITAMs on the immunoglobulin domains of the receptor (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• B cell receptor pathway in chronic lymphocytic leukemia: specific role of CC-292 (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Wnt inhibitors currently in clinical trials (2014, Lareunionomyces loeiensis,Sequoia sempervirens,Homo sapiens,Mus musculus,Drosophila melanogaster,Mouse mammary tumor virus)
• Canonical Wnt signaling.Notes: (A) Wnt off (2014, Lareunionomyces loeiensis,Sequoia sempervirens,Homo sapiens,Mus musculus,Drosophila melanogaster,Mouse mammary tumor virus)
• Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation (2014, NA)
• CD180 is a close relative of TLR4 and together with BCR signaling can promote B-cell activation and differentiation (2014, NA)
• Putative functions of the differentially expressed proteins in metabolic processes of rice grain development at high temperatures (2014, Arabidopsis thaliana,Oryza sativa,Zea mays,Triticum aestivum,Hordeum vulgare,Helianthus annuus,Oryza sativa Japonica Group,Mimosa pudica,Geobacillus stearothermophilus,Thermus aquaticus,Homo sapiens,Nilaparvata lugens)
• Three retinal pathways for blue-green color vision (2014, Homo sapiens,Oryctolagus cuniculus)
• Mechanism of n-3 PUFA-mediated neuroprotection (2014, NA)
• Wnt/GSK- 3B pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt signalling pathway in developing muscle-less humeri (2014, NA)
• Starvation Increases Insulin Sensitivity and Reduces Juvenile Hormone Synthesis in Mosquitoes (2014, Drosophila melanogaster,Plasmodium falciparum,Apis mellifera,Aedes aegypti,Anopheles stephensi,Termitoidae,Blattella germanica,Argynnis mormonia,Bos taurus,Homo sapiens)
• Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,NA)
• Reverse cholesterol transport pathway delivers free cholesterol from macrophages or other cells to the liver or intestine for excretion (2014, Homo sapiens)
• AT2R-mediated molecular pathways involved in tissue injury (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• ROS generation and its effect on angiogenesis (2014, NA)
• Panx3 signaling pathways inhibit osteoprogenitor cell proliferation and promote cell cycle exit (2014, Mus musculus,Homo sapiens)
• Role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy (2014, NA)
• Simplified view of insulin/IGF1 signaling (2014, NA)
• Schematic diagram showing the multi-regulation loops of LRRC4/NGL-2, miRNAs, TFs and target genes in glioma (2014, NA)
• Schematic diagram showing the signaling regulation network of LRRC4/NGL-2 in glioma (2014, NA)
• Cell Surface Area and Membrane Folding in Glioblastoma Cell Lines Differing in PTEN and p53 Status (2014, NA)
• EGFR and FGFR Pathways Have Distinct Roles in Drosophila Mushroom Body Development and Ethanol-Induced Behavior (2014, Drosophila melanogaster,Venustaconcha ellipsiformis,Homo sapiens,Mus musculus,Capra hircus,Agaricus bisporus)
• Bacteria Induce Prolonged PMN Survival via a Phosphatidylcholine-Specific Phospholipase C- and Protein Kinase C-Dependent Mechanism (2014, NA)
• Rho1 GTPase and PKC Ortholog Pck1 Are Upstream Activators of the Cell Integrity MAPK Pathway in Fission Yeast (2014, NA)
• Reaction network of the vascular endothelial growth factor receptor (VEGFR) signaling model (2014, Homo sapiens)
• NOD1 signaling and interactions with Rho GTPases and NFATc (2014, Escherichia coli,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pneumoniae,Clostridioides difficile,Shigella flexneri,Haemophilus influenzae,Chlamydia trachomatis,Candidatus Sodalis pierantonius str. SOPE,Clostridioides difficile CD18,Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Mus musculus)
• Differential network of breast cancer Cell Cycle pathway between early recurrent and non-recurrent patients (2014, Homo sapiens,Mus musculus,synthetic gene)
• Molecular regulation of hepcidin by iron and inflammation (2014, NA)
• Scheme of the effect of the Toona sinensis and Moschus decoction on cell cycle arrest in HeLa cells (2014, Toona sinensis,Homo sapiens)
• Shifting ecologies of malignant and nonmalignant cells following BRAF inhibition (2014, Homo sapiens)
• Pathway model showing two distinct roles for Sck1 in nutrient signaling (2014, NA)
• Metabolic potential of Acidilobus-like populations from YNP deduced from coding sequences obtained from metagenome assemblies (2014, cellular organisms)
• Schematic model depicting the proposed signaling pathway in LH/hCG-induced LHR mRNA down regulation (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Stathmin 1 signaling pathway (2014, NA)
• Profiling of Concanavalin A-Binding Glycoproteins in Human Hepatic Stellate Cells Activated with Transforming Growth FactorB1 (2014, Armoracia rusticana,Canavalia ensiformis,Aleuria aurantia,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Corynephage beta,NA)
• HIF-1A regulation through the ERK signaling pathway in liver fibrosis (2014, Olea europaea,Curcuma longa,Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus)
• Canonical Wnt signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,prion)
• Sites of canonical Wnt signaling deregulation in PD (2014, Homo sapiens,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens neanderthalensis,Mus musculus,Mouse mammary tumor virus)
• Schematic model for how S6K1 inhibits TLR2- or TLR4-mediated signaling pathways (2014, NA)
• Schematic diagram depicting the diverse outcomes of KSHV-induced 5LO and LTB4 in ECs and the consequences and roles of KSHV in viral pathogenesis (2014, Homo sapiens,Human gammaherpesvirus 8,Capra walie)
• Summary model for rAdV DNA sensing (2014, NA)
• Proposed signaling pathways involved in HbR-induced IL-8 production (2014, NA)
• GSK3B and phospho-GSK3B regulate milk synthesis and DCMEC proliferation via the mTOR/S6K1 signaling pathway (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes (2014, Homo sapiens,Mus musculus,Bos taurus,Staphylococcus aureus,Human papillomavirus,vectors)
• Shift in glycolytic-mitochondrial energetics after T-H (2014, NA)
• The PI3K signaling pathway and sides of action PI3K/Akt/mTOR pathway inhibitors (2014, Homo sapiens)
• Interaction of CLL cells and the lymph node microenvironment (2014, NA)
• The sphingolipid rheostat in AD context (2014, NA)
• IGF signaling involvement in EMT (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• TGFB pathway in muscular dystrophy (2014, NA)
• The interplay between the canonical Wnt/Beta-catenin pathway and IGF signaling (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• The cross-talks between the Notch and the IGF signaling (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Proposed model for the interaction between Shh and IGF signaling (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Hedgehog signaling pathway in cancers -Type III- Paracrine Ligand-dependent cancers (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Zea mays)
• Signaling pathways involved in the control of skeletal muscle atrophy and hypertrophy (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster)
• Proposed mechanisms underlying the cellular responses to t-BHP after pre-treatment with Rb1 via Nrf2/HO-1 signaling pathway (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Panax ginseng,Schaalia meyeri)
• Intrahepatic interplays among hepatocytes, non-parenchymal cells (NPC) and lymphocytes and illustration of antiviral and immunotherapeutic strategies (2014, NA)
• BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo (2014, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• IL-6 exerts its pleiotropic activity by activation of gp130 through its binding to transmembrane or soluble IL-6 receptor (2014, Homo sapiens,Mus musculus)
• The PI3K/Akt/mTOR pathway substrates and associated cellular functions (2014, NA)
• Ginsenoside Metabolite Compound K Promotes Recovery of Dextran Sulfate Sodium-Induced Colitis and Inhibits Inflammatory Responses by Suppressing NFKB Activation (2014, NA)
• PTTH and insulin signaling pathways in lepidopteran ecdysone secretion (2014, Drosophila melanogaster,Bombyx mori,Manduca sexta,Rhodnius prolixus,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana)
• cIAP1/2 regulation of TNFAlpha-induced canonical NFKB pathway activation and suppression of default death pathways (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Lama glama)
• cIAP1/2 regulation of TWEAK-induced non-canonical NFKB pathway activation (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Lama glama)
• Differential activation of NFKB pathways by TWEAK based on strength of Fn14 signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Lama glama)
• Growing recognition of the role for rare missense substitutions in breast cancer susceptibility (2014, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Canis lupus familiaris,unidentified)
• Induction of NLRP3 inflammasome complex by the inorganic crystal HZ (2014, NA)
• Interactomic analysis by Ingenuity Pathway Analysis (IPA) of significant molecules (2014, Punica granatum,Homo sapiens)
• Suggested mechanisms of synergistic cytotoxicity of [Gem+Clo+Ed] combination in lymphoma cells based on the previously reported data and our present results (2014, NA)
• VEGF signaling pathway in HemECs and HemSCs (2014, NA)
• Beta-adrenergic signaling modulates multiple cellular processes in tumor progression and metastasis (2014, NA)
• Insulin signaling in ovarian thecal cells and proposed mechanisms for selective insulin resistance (2014, NA)
• Wnt signaling pathway members: Central to this pathway is a multiprotein scaffold composed of adenomatous polyposis coli (APC), glycogen synthase kinase (GSK)–3B, axin and the transcriptional cofactor Beta-catenin (2014, NA)
• EBV interaction with the Bcl family (2014, Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Human papillomavirus types,Aurantiochytrium single-stranded RNA virus 01,Human T-cell lymphotropic virus,Human T-lymphotropic virus 2,Saccharomyces cerevisiae,Isodon rubescens,Homo sapiens,Mus musculus,Xenopus laevis,NA,NA)
• Apoptotic cell death pathways and (b) inhibition of the apoptosis signalling pathway (2014, Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Human papillomavirus types,Aurantiochytrium single-stranded RNA virus 01,Human T-cell lymphotropic virus,Human T-lymphotropic virus 2,Saccharomyces cerevisiae,Isodon rubescens,Homo sapiens,Mus musculus,Xenopus laevis,NA,NA)
• BCR/BTK signaling pathway (2014, NA)
• Flow diagram representing the molecular interactions in the Toll-like receptor signaling pathway (from KEGG database) (2014, NA)
• Scheme of PI3K/PTEN/AKT signaling network activated by heterodimerization of HER2/HER3 receptors induced by heregulin (HRG) and inhibited by pertuzumab, 2C4 (2014, Homo sapiens,Phengaris arion)
• Bayesian network models for ovarian cancer (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular targets and associated therapies to block three immunosuppressive checkpoints in a malignant brain tumor (glioma) model (2014, NA)
• Illustration of molecular pathway for significantly associated single nucleotide polymorphism (SNP) loci in the metabolic syndrome genome-wide association study (GWAS) (2014, NA)
• Wnt signaling pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG) (SFRP genes are in red box) (2014, Homo sapiens,Eucalyptus intertexta)
• The kynurenine metabolic pathway (2014, NA)
• Physiological functions of the P2X7 receptor in bone cells (2014, NA)
• The signaling transduction throughout integrin engagement by Cp aged under oxidative conditions (2014, NA)
• Estrogen receptor (ER) pathway includes the canonical and the non-canonical ER pathways (2014, NA)
• Crosstalk of signaling pathways in breast cancer and the potential clinical therapeutic targets (2014, NA)
• Interaction network of differentially methylated diabetic genes (2014, NA)
• Chondroitin sulfate and HS biosynthesis (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Danio rerio)
• Ca2+ transport remodelling in promotion of cancer cell proliferation (2014, NA)
• Ca2+ transport remodelling in conferring apoptosis resistance in cancer cells (2014, NA)
• The classical complement pathway initiated by mAbs and its inhibitors (2014, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Macaca fascicularis,Lareunionomyces loeiensis)
• Ca2+ transport remodelling in tumour vascularization (2014, NA)
• Functional properties of ion channels and transporters in tumour vascularization (2014, NA)
• Specific targets and potential therapeutic strategies to inhibit or slow the progression of CKD (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Dual regulatory effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on neuronal apoptosis (2014, Homo sapiens)
• NRF2-KEAP1 Pathway Is an Early Responsive Gene Network in Arsenic Exposed Lymphoblastoid Cells (2014, Gallus gallus,Calloplesiops altivelis,Homo sapiens,Mus musculus,Bos taurus)
• FGF-FGFR signaling pathway (2014, NA)
• E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis (2014, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications (2014, NA)
• BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications (2014, NA)
• BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications (2014, NA)
• BRAF vs RAS oncogenes: are mutations of the same pathway equal? differential signalling and therapeutic implications (2014, NA)
• Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/Beta-catenin pathway (2014, NA)
• Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and for growth inhibition of breast cancer cells and cancer stem-like cells (2014, NA)
• EBV-driven LMP1 and IFNG up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy (2014, Bos taurus,Oryctolagus cuniculus,Human gammaherpesvirus 4,Human papillomavirus type 16,Equus asinus,Merkel cell polyomavirus,Homo sapiens,Mus musculus,Helicobacter pylori)
• 49 genes whose functional domains were changed by DAS exons (2014, NA)
• PI3K/Akt/mTOR signaling pathway (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Coregonus peled,Protobothrops flavoviridis,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris)
• TGFB signaling and MMPs interplay (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Mouse mammary tumor virus)
• Induction of apoptosis (2014, NA)
• Tumor cell resistance to antineoplastic therapy through angiopoietin-like protein 2 (ANGPTL2) expression (2014, NA)
• Disease-specific mutations in B-cell lymphoid neoplasms (2014, NA)
• Convergence of signaling molecules in the vicinity of membranes and synergistic enhancement of the signaling and phenotypes in ganglioside GD3+ N1 cells (2014, NA)
• Simplified models depicting rapid estrogen receptor signaling (left) and classical nuclear pathway (right) (2014, NA)
• Integrated metabolic pathway of BCAA metabolism (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli,Middle East respiratory syndrome-related coronavirus,Anser sp.,NA)
• Anabolic pathway of renal sulfatides (2014, NA)
• Impact of BRAFi on T cell response to melanomas (2014, NA)
• Human iPSCs harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming (2014, NA)
• CNP action in the SRG (2014, NA)
• TLR ligands/DAMPs, cellular location, and signaling in the vasculature (2014, NA)
• Schematic overview of the regulation of GLUT4 translocation (2014, Homo sapiens)
• Secretion of FABP4 in association with lipolysis (2014, NA)
• Schematic of the signaling pathways activated by the P2Y2R in endothelial cells that are thought to regulate vascular permeability (2014, NA)
• Mechanism of ICL repair in the FA pathway on collision of a replication fork with an ICL (2014, NA)
• Signal transduction pathway mediating the suppression of sIAHP by PACAP in CA1 pyramidal neurons (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Single Nucleotide Polymorphisms in MicroRNA Binding Sites of Oncogenes: Implications in Cancer and Pharmacogenomics (2014, NA)
• NFKB signaling pathway and its regulation by influenza virus (2014, NA)
• APP glycosylation through intracellular secretory pathway (2014, NA)
• Chitinase 3-like 1-associated Beta-catenin activation signaling pathway, which is inhibited by methylxanthine derivatives (2014, NA)
• Molecular pathways associated with CD133 (2014, NA)
• Representation of epidermal growth factor receptor pathway in response to therapy with anti-epidermal growth factor receptor inhibitors in wild-type and mutant patients (2014, NA)
• Protein interaction network analysis of the up-regulated proteins in M (2014, NA)
• Integrated cell death pathway model linking drought stress and ER stress (2014, NA)
• Molecular mechanism on Trx-1 regulating chronic epinephrine stress (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pancreatic cancer pathway diagram (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryza sativa)
• Differential expression of mTOR and HIF-1A pathways between leiomyoma, HLRCC and leiomyosarcoma (2014, NA)
• (See previous page) (2014, NA)
• Feedback regulation of PI3K/Akt/mTORC1 signaling by Grb10 (2014, NA)
• Proliferation versus arrest (2014, Saccharomyces cerevisiae,Homo sapiens)
• Loss of AV increases CTR1 expression affecting cDDP sensitivity and Cu-related signaling pathways (2014, NA)
• Schematic overview of the elements of the cAMP signal transduction pathway in cardiac myocytes (2014, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model integrating viral and host biomarkers for disease severity and the effect of IFNB in HAM/TSP (2014, NA)
• Proposed mechanisms of evodiamine signaling in white adipocytes (2014, NA)
• Tonic excitatory drive and the control of neuronal rhythms (2014, NA)
• Human disease mutations in short linear motifs (2014, NA)
• Co-regulation of hepatic wound healing and regenerative responses via TWEAK- and LTBeta-mediated cellular cross-talk (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Recent Advances in Metabolic Profiling And Imaging of Prostate Cancer (2014, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples,NA)
• Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Turdus migratorius)
• Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Turdus migratorius)
• Tumor necrosis factorA and its osteoblastogenesis paradoxical effects (2014, NA)
• Diagram of SCCA1/2 (SerpinB3/B4) as critical mediators in Ras-driven cancers (2014, NA)
• Components that determine the establishment and tolerance-inducing capacity of tolerogenic effector DCs (2014, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer (2014, NA)
• Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer (2014, NA)
• Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer (2014, NA)
• PPAR signalling pathway (2014, NA)
• Piece #2: The BCL-2 family controls BAK/BAX activation and MOMP (2014, NA)
• Piece #1: Tumor suppressor and oncogenic pathways converge on the mitochondrial pathway of apoptosis (2014, NA)
• Impairment of T Cell Function in Parasitic Infections (2014, NA)
• BiNA: A Visual Analytics Tool for Biological Network Data (2014, Homo sapiens,Mus musculus,Pandion haliaetus)
• Gene product interaction network of immune and inflammatory responsive genes associated with smoking in females generated from the information in the Ingenuity knowledge base, version 7.6 (2014, NA)
• MAPK signaling pathway showing the target genes of microRNAs (2014, NA)
• Dominant negative LMP1 inhibits proliferation of CAEBV T cells (2014, NA)
• Overall mechanism of leptin-mediated activation of downstream signalling (2014, NA)
• Mitochondrial function on HSC maintenance and ROS production (2014, NA)
• Metabolic crosstalk between key signaling pathways in stem cells via ROS and other metabolic co-factors (2014, NA)
• Schematic plot of lncRNAs expressed in NSCLCs and their functions (2014, NA)
• Experimental design (2014, Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,vectors,Clostridium septicum)
• Control of the core Hippo signaling pathway through interacting upstream modules (2014, NA)
• Hippo pathway-mediated regulation of cell lineage and pluripotency by adhesion and epithelial polarization in the early mouse embryo (2014, NA)
• Hippo pathway mediates the reciprocal regulation of cell proliferation by contact inhibition and mitogenic signaling (2014, NA)
• Three pathways of complement activation: classical, lectin, and alternative pathways (2014, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Streptococcus sp. group A,Streptococcus agalactiae,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Salmonella enterica subsp. enterica serovar Minnesota,Streptococcus sp.,Aerococcus viridans,Plasmodium falciparum,Trypanosoma cruzi,Schistosoma mansoni,Giardia intestinalis,Leishmania braziliensis,Leishmania chagasi,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Osphranter robustus,NA)
• Biological functions of the complement system (2014, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Streptococcus sp. group A,Streptococcus agalactiae,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Salmonella enterica subsp. enterica serovar Minnesota,Streptococcus sp.,Aerococcus viridans,Plasmodium falciparum,Trypanosoma cruzi,Schistosoma mansoni,Giardia intestinalis,Leishmania braziliensis,Leishmania chagasi,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Osphranter robustus,NA)
• Two mechanisms for growth-factor-mediated regulation of the Hippo pathway: activation of Ras-MAPK signaling and activation of PI3K-PDK1 signaling (2014, NA)
• Gene ontology (GO) analysis using the DAVID software (2014, NA)
• A6 integrin is the upstream regulator of the IGF-1R signaling pathway that enables low levels of caspase-3 activation to signal lens epithelial cell differentiation initiation (2014, Mus musculus,Gallus gallus,Homo sapiens)
• MARCKS Is Marked in Combating Lung Cancer Growth and Acquired Resistance (2014, NA)
• Regulation of Toll-like receptor (TLR) signaling during bacterial lung infections (2014, Homo sapiens)
• Mechanisms underlining the sphingosine-1-phosphate (S1P)/sphingosine kinase 1 (SphK1)/S1P receptor (S1PR) 2 signaling axis in pulmonary arterial hypertension (PAH) (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Select upstream regulators and downstream effectors of mTOR signaling (2014, NA)
• Endocrine system development and function (2014, Gallus gallus,Meleagris gallopavo,catfish,Bos taurus,Cervus elaphus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Salmonella enterica subsp. enterica serovar Enteritidis)
• Cell signaling (2014, Gallus gallus,Meleagris gallopavo,catfish,Bos taurus,Cervus elaphus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Salmonella enterica subsp. enterica serovar Enteritidis)
• MAPK pathways in healthy donors (2014, NA)
• Role of EGFR in the establishment of epithelial polarity (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Cavia porcellus,Matthiola incana,Pinus torreyana,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Suppression of ghrelin signaling mitigates age-associated thermogenic impairment (2014, NA)
• Neural redox reactions (2014, NA)
• Mechanosignaling in Bone Health, Trauma and Inflammation (2014, NA)
• Mechanosignaling in Bone Health, Trauma and Inflammation (2014, NA)
• The effect of quercetin on obesity-induced skeletal muscle inflammation and muscle atrophy (2014, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Glycine max)
• Generation of ceramide and FTY720-P (2014, NA)
• Role of BRCA in DNA damage response pathway is regulated by h HSS1-overexpression in U87 cells (2014, Saccharomyces cerevisiae,Xenopus laevis,Schizosaccharomyces pombe,Sequoia sempervirens,Cyprinus carpio,Cyprinus carpio color,Mus musculus,Cricetulus griseus,Homo sapiens,Drosophila melanogaster)
• New Function of Type I IFN: Induction of Autophagy (2014, NA)
• NFKB signaling pathway (see text for details) (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Oryza sativa)
• New Function of Type I IFN: Induction of Autophagy (2014, NA)
• Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat (2014, NA)
• Critical role of NFKB in pancreatic cancer (2014, NA)
• Cytokines and their receptors regulating peripheral B-cell survival (2014, NA)
• Regulatory pathways for SREBP-1c signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic depiction of some of the Ca2+ channels, pumps and exchangers involved in Ca2+signalling in mammalian cells (2014, NA)
• Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells (2014, Saccharomyces cerevisiae,Diaporthe sclerotioides,Penicillium commune,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Host genes with reproducible microbiome associations across cohorts (2014, NA)
• Gene network analysis of top HHT associated genes (2014, NA)
• Insulin growth factor 1 (IGF-1) signaling pathway (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Homo sapiens,clinical samples,Betapolyomavirus macacae)
• Possible mechanisms underlying modulation of TLR-induced DC activation by MARCO (2014, NA)
• Possible pathways of IL-4 and IL-13 signaling in pancreatic Beta-cells (2014, NA)
• Assembly and mechanism of action of CpG ODN/Tat nanorings (2014, NA)
• TRAF4 function on TJs (2014, Drosophila melanogaster,Hippospongia communis,Homo sapiens,Agaricus bisporus,NA)
• Cell signaling pathways are allosterically elicited by the activated receptor tyrosine kinase (RTK) (2014, NA)
• EGFR signaling and autophagy dependence for growth, survival, and therapy resistance (2014, NA)
• The proposed neuroprotective mechanism of FtMt in AD (adapted from ; Antioxid Redox Signal) (2014, NA)
• Signalling pathway and endogenous antagonists of IL-1B and IL-18 (2014, NA)
• Functional role of PI3K and PTEN in chemotaxis (2014, NA)
• ManLAM and PIM action on phagosome maturation and autophagy (2014, NA)
• Structural model of and cell signaling pathways triggered by ManLAM and its biosynthetic precursors LM and PIMs (2014, NA)
• Signaling pathway of coagulation cascade for schizophrenia (2014, Homo sapiens,Rattus norvegicus,Diaporthe sclerotioides,Corynephage beta)
• Schematic summary of the inhibition mechanisms of ZJW on the PI3K/Akt/NFKB signaling pathway (2014, herbal medicine,Coptis chinensis,Homo sapiens,Mus musculus,Bos taurus)
• Molecular pathogenesis and therapeutics of Marfan syndrome (MFS) (2014, NA)
• Distraction-Induced Intestinal Growth: The Role of Mechanotransduction Mechanisms in a Mouse Model of Short Bowel Syndrome (2014, NA)
• Enriched pathway of the target gene union of radiation-response miRNAs (2014, NA)
• Signaling pathways associated with capacitation-related proteins (2014, NA)
• Example of difference between LW and MS at fetal gestational age 110: pathway of Gluconeogenesis (2014, Bos taurus,Sus scrofa,Ovis aries,Sus scrofa domesticus,Homo sapiens,Pieris brassicae)
• Repetitive hypoxic preconditioning suppresses adaptive immune responses in resident B cells prior to stroke (2014, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Diaporthe sclerotioides,Borreliella burgdorferi)
• Cytokine-induced differentiation of human B cells in vitro: requirement for IL-21 signaling in vivo (2014, NA)
• Impact of IBD genetic polymorphisms on dendritic cell function (2014, NA)
• A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS) (2014, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Mus musculus,clinical samples)
• The NGF metabolic pathway in healthy brains and its deregulation in Down’s syndrome (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• AMP-activated protein kinase (AMPK) beyond metabolism (2014, NA)
• Fibroblast Low-density lipoprotein (LDL)-related protein-1 (LRP-1) signaling in renal fibrogenesis (2014, NA)
• Summary of the p53 pathway (2014, NA)
• Schematic diagram describing the mechanism by which Naringenin (NAR) inhibits osteoclast differentiation and function (2014, Citrus x paradisi,Neocheiropteris fortunei,Taraxacum formosanum,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• ITCH E3 ligase in ATM network (2014, NA)
• Summary of proposed mechanism of inhibition of inflammatory Src signaling by local anesthetics (2014, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus caballus,Diaporthe sclerotioides,Raphanus sativus,Homo sapiens,Mus musculus,Escherichia coli,Plasmodium falciparum)
• AMP-activated protein kinase (AMPK) beyond metabolism (2014, NA)
• AMP-activated protein kinase (AMPK) beyond metabolism (2014, NA)
• Signaling pathway interaction and effects of modulators: cGMP and cAMP-dependent intracellular signaling systems in the insulin-mediated regulation of platelet aggregation in patients with metabolic disorders (2014, NA)
• AMP-activated protein kinase (AMPK) beyond metabolism (2014, NA)
• Notch signaling modules relevant for brain tumors (2014, NA)
• Canonical Notch signaling with points of intervention of current therapies (2014, NA)
• AMP-activated protein kinase (AMPK) beyond metabolism (2014, NA)
• Shigella flexneri targets the HP1G subcode through the phosphothreonine lyase OspF (2014, Shigella flexneri)
• Schematic for analytical methods used to delineate between hydroxycinnamates, p-coumarate and ferulate, on lignin versus on polysaccharides (2014, NA)
• Pathways implicated in Alzheimer's disease (AD) (2014, Homo sapiens,Mus musculus,Major minor)
• Regulation of cellular actomyosin dynamics by Rho-GTPases (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Citrus medica,Derris trifoliata,Homo sapiens,Drosophila melanogaster,Human immunodeficiency virus 1,Xenopus laevis,Bacillus anthracis)
• Telling the story of a gastric cancer through sequencing and functional studies (2014, NA)
• miR-93-directed down-regulation of DAB2 defines a novel oncogenic pathway in lung cancer (2014, NA)
• NOD2-interaction partners influence a wide range of NOD2 functions (2014, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Bacillus anthracis,Shigella flexneri,Vibrio cholerae non-O1non-O139,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes (2014, NA)
• Inositol phosphates and Akt/PKB inhibition, a potential Akt/PKB feedback mechanism.Note: Adapted from Cell, 143(6), Manning BD, Insulin signaling: inositol phosphates get into the Akt, 861–863 (2014, NA)
• Solving Glycosylation Disorders: Fundamental Approaches Reveal Complicated Pathways (2014, NA)
• Schematic representation of the HTRA2 protein and its activation against mitochondrial stress (2014, Homo sapiens,Mus musculus)
• Integrated model of NDV-3–mediated protective efficacy versus MRSA in murine SSSI (2014, Homo sapiens,Mus musculus,Staphylococcus aureus)
• TLRs signaling pathway (2014, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Listeria monocytogenes,Chlamydia trachomatis,Neisseria gonorrhoeae,Streptococcus sp. group B,Treponema pallidum,Human immunodeficiency virus 1,Hepatitis B virus,Human alphaherpesvirus 1,Human alphaherpesvirus 2,Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, NA)
• Pharmacology network-based drug repurposing for CMT1A disease (2014, NA)
• Enriched synaptic long-term potentiation canonical pathway , identified by ingenuity pathway analysis based on differentially expressed genes ( P value  <  0.05 ) with the ordinary student’s t -test (2014, Saccharomyces cerevisiae,Nicotiana tabacum,Ephedra major,Mus musculus,Rattus norvegicus,Helicobacter pylori,Helicobacter pylori 8A3,Homo sapiens,Drosophila melanogaster)
• The SD and ED metabolic pathways in PHB accumulation recombinant E.coli (2014, Escherichia coli)
• CCL5 promotes VEGF-dependent angiogenesis by down-regulating miR-200b through PI3K/Akt signaling pathway in human chondrosarcoma cells (2014, Bos taurus,Oryctolagus cuniculus,Equus asinus,Armoracia rusticana,Rheum palmatum,Homo sapiens,Mus musculus,Gallus gallus)
• Under physiological conditions, ERK signaling is regulated by extracellular signals binding to receptor tyrosine kinases (RTKs) (2014, NA)
• Signaling modulating adherens junctions (AJs) (2014, NA)
• In silico functional analyses and discovery of survival-associated microRNA signatures in pediatric osteosarcoma (2014, NA)
• NMI and EMT (2014, Homo sapiens)
• SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types (2014, NA)
• Altered metabolic pathways in clear cell renal cell carcinoma: A meta-analysis and validation study focused on the deregulated genes and their associated networks (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, NA)
• Estrogen, HER2 signalling, and the PI3K/Akt pathway in drug-resistant breast cancer.Notes: ER can activate gene transcription by nuclear translocatin following ligand binding (1) or as a result of receptor phosphorylation in the absence of ligand (2) (2014, NA)
• Regulation of Hippo-Yap1/Taz signaling by polarity complexes (2014, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio,Mouse mammary tumor virus)
• Deficient Phosphorylation of Stat1 in Leukocytes Identifies Neutralizing Antibodies in Multiple Sclerosis Patients Treated with Interferon-Beta (2014, NA)
• ReNE: A Cytoscape Plugin for Regulatory Network Enhancement (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Caenorhabditis elegans)
• Snapshot of the Hepatic Transcriptome: Ad Libitum Alcohol Intake Suppresses Expression of Cholesterol Synthesis Genes in Alcohol-Preferring (P) Rats (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Reactome mapping of differentially-expressed genes (2014, NA)
• Three intracellular signaling pathways are shown schematically (2014, Zea mays,Syzygium aromaticum,Homo sapiens,Mus musculus,prion,clinical samples,Paraba multicolor)
• Reduced HIF-1A expression in TRPM2-S-expressing cells determined by proteomic analysis (2014, NA)
• Wnt-5a ligand activates Wnt/Ca2+pathway and induces mitochondrial dynamics in post-synaptic regions (2014, NA)
• Tpl2-ERK activation during TLR signaling (2014, NA)
• PPARG signaling pathway during high-altitude vs sea-level pregnancy (2014, NA)
• Regulation of miRNAs in NHL (2014, NA)
• Top ranked network of genes altered in the newborn lung at 24h post-O3 exposure (2014, NA)
• Second ranked network of genes altered in the newborn lung at 24h post-O3 exposure (2014, NA)
• Epidermal growth factor (EGF-EGFR) signalling pathway in hepatocellular carcinoma (HCC) inflammatory microenvironment (2014, NA)
• Metabolic pathways that lead to the production of fatty acids and fatty acid-derived chemicals (2014, NA)
• KEGG pathway of 470 DEGs downregulated in the frontal cortex of AD identified by RNA-Seq data analysis (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Bν Integrin Inhibits Chronic and High Level Activation of JNK to Repress Senescence Phenotypes in Drosophila Adult Midgut (2014, NA)
• BCR-ABL levels govern engagement and evasion of tumor suppression in hematopoietic precursors, thereby controlling CML transformation (2014, Homo sapiens,Mus musculus,Bellapiscis medius)
• Global view on the intracellular proteome profile change in P (2014, Saccharomyces cerevisiae,Matthiola incana,Komagataella pastoris,Rhizopus arrhizus,Komagataella phaffii GS115,Moesziomyces antarcticus,Homo sapiens,Mus musculus,Bos taurus)
• Activation of the ATR-signaling pathway during G1/G0 or G2-M phases of the cell cycle (2014, Homo sapiens,Mus musculus)
• The structure-function relationships of IRAK-M based on this study (2014, NA)
• Molecular mechanisms of alcoholic fibrosis (2014, NA)
• Candidate genes influenced by Zn2+ or involved in Zn2+signaling and metal ion homeostasis associated with the development of ASDs (2014, NA)
• Breast cancer pathway (2014, NA)
• Immune, antioxidant and inflammatory targets that L-glutamine, L-arginine and BCAA are involved (2014, NA)
• Signaling by EGF and PDGF in the regulation of Beta-cell proliferation (2014, NA)
• Signaling by leptin, Wnt, and Beta-catenin in the regulation of Beta-cell proliferation (2014, NA)
• Flux map for accession 3231 (13C-MFA) (2014, NA)
• FGF signaling specifies hematopoietic stem cells through its regulation of somitic Notch signaling (2014, Bos taurus,Gallus gallus,Danio rerio,Capra hircus,Xenopus laevis,Equus asinus,Homo sapiens,Mus musculus)
• OAA effects and inter-effect relationships (2014, Mus musculus,Homo sapiens)
• Loss of Arabidopsis thaliana Dynamin-Related Protein 2B Reveals Separation of Innate Immune Signaling Pathways (2014, Arabidopsis thaliana,Homo sapiens)
• Multitask Learning of Signaling and Regulatory Networks with Application to Studying Human Response to Flu (2014, Influenza A virus,unidentified influenza virus,H1N1 subtype,West Nile virus,H5N1 subtype,H3N2 subtype,Influenza A virus H3N2,H1N2 subtype,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Examples of non-stress-related peroxide signaling (2014, NA)
• Akt signaling pathway (2014, NA)
• EHEC-host interactome reveals novel targets for the translocated intimin receptor (2014, Escherichia coli,Bacillus anthracis,Shigella flexneri,Francisella tularensis,Escherichia coli O157H7,Yersinia pestis,Escherichia coli str. K-12 substr. DH10B,Escherichia coli O157,Escherichia coli O157H7 str. Sakai,Shigella dysenteriae 1,Escherichia coli O127H6 str. E234869,unidentified influenza virus,Vaccinia virus,Human alphaherpesvirus 3,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Major pathways for glucose and lactate metabolism (2014, NA)
• Transforming growth factor (TGF)-beta signaling pathway (2014, Homo sapiens,Mus musculus,Danio rerio,Sus scrofa)
• Diagram depicting the signaling pathway by which the constitutive PKA activity regulates the spontaneous TBKCs and thus UBSM excitability and contractility (2014, Cavia porcellus,Homo sapiens)
• Spatiotemporal regulation of feeding response by O-GlcNAcylation (2014, Homo sapiens,Mus musculus)
• Type 3 deiodinase expression on Warburg phenotype (2014, NA)
• Complementary metabolic pathways between the brown planthopper and its yeast-like symbiont (2014, Drosophila melanogaster,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Tribolium castaneum,Acyrthosiphon pisum,Nilaparvata lugens,Culex quinquefasciatus,Rhodnius prolixus,Tetranychus urticae,Myzus persicae,Locusta migratoria,Daphnia pulex,Heliothis virescens,Pediculus humanus,Laodelphax striatellus,Danaus plexippus,Cimex lectularius,Nasonia vitripennis,Sitobion avenae,Brevicoryne brassicae,Camponotus floridanus,Lipaphis erysimi,Apolygus lucorum,Trialeurodes vaporariorum,Anagrus nilaparvatae,Euschistus heros,Adelphocoris lineolatus,Drepanosiphum platanoidis,Saccharomyces cerevisiae,Oryza sativa,PX clade,Vasconcellea candicans,Metarhizium acridum,Maclura pomifera,Morus rubra,Hamiltonaphis styraci yeast-like symbiont,Escherichia coli,Escherichia coli IS29,Arsenophonus nasoniae,Homo sapiens,Oryctolagus cuniculus,Ailuropoda melanoleuca,Macaca nigra,Middle East respiratory syndrome-related coronavirus,Salmo salar)
• PI3K/Akt signalling pathway (2014, NA)
• Wnt/Beta-catenin pathway (2014, NA)
• Summary of regulatory networks centered by typical 2-Cys Prxs (2014, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Autophagy is negatively regulated by the phosphatidylinositol 3-kinase (PI3 K)/Akt signaling pathway, which activates mammalian target of rapamycin (mTOR) in response to growth factors and also phosphorylates Beclin 1 (2014, NA)
• Autophagy has a complex relationship with various modes of cell death, including regulated (e.g., apoptosis, pyroptosis, and necroptosis) and catastrophic (e.g., necrosis) types of cell death (2014, NA)
• Schematic showing the interference of Hepatitis C virus in the insulin signaling pathway (2014, NA)
• Effect and mechanisms of HDL‐induced platelet activation and thrombosis (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Candida dubliniensis,bacterium 1-smooth)
• Cartoon presentation of LRRK2 showing multidomain structure (2014, NA)
• Systems Biology Investigation of cAMP Modulation to Increase SMN Levels for the Treatment of Spinal Muscular Atrophy (2014, NA)
• RNA-Seq Analysis of Equine Conceptus Transcripts during Embryo Fixation and Capsule Disappearance (2014, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Petrocephalus catostoma)
• Signaling pathways in lung cancer (2014, NA)
• Multifunctional organoboron compounds for scalable natural product synthesis (2014, Homo sapiens)
• The roles of the RuvBL1-RuvBL2 complex in regulating the FA DNA repair pathway (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Helianthus annuus,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• A proposed protective mechanism mediated by the H19/let-7 axis (2014, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Role of Notch signaling in the mammalian heart (2014, NA)
• Role of Notch signaling in the mammalian heart (2014, NA)
• Alcohol affects local translation of proteins in amygdala of alcohol-dependent rats (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Caenorhabditis elegans,prion)
• NOD1 and NOD2 signaling (2014, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Salmonella enterica,Klebsiella pneumoniae,Vibrio cholerae,Clostridioides difficile,Porphyromonas gingivalis,Bacillus anthracis,Shigella flexneri,Mycobacterium tuberculosis variant bovis,Citrobacter rodentium,Francisella tularensis,Legionella pneumophila,Chlamydia pneumoniae,Francisella tularensis subsp. novicida,Vibrio vulnificus,Mycoplasmoides pneumoniae,Mycobacterium avium subsp. paratuberculosis,Clostridioides difficile CD8,Escherichia coli O111B4,Chlamydia muridarum,Moraxella catarrhalis,Mycobacterium sp.,Aeromonas veronii,Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Mus musculus,Rattus norvegicus,Influenza A virus,unidentified influenza virus,Trypanosoma cruzi,Toxoplasma gondii,Homo sapiens)
• TLRs signaling (2014, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Salmonella enterica,Klebsiella pneumoniae,Vibrio cholerae,Clostridioides difficile,Porphyromonas gingivalis,Bacillus anthracis,Shigella flexneri,Mycobacterium tuberculosis variant bovis,Citrobacter rodentium,Francisella tularensis,Legionella pneumophila,Chlamydia pneumoniae,Francisella tularensis subsp. novicida,Vibrio vulnificus,Mycoplasmoides pneumoniae,Mycobacterium avium subsp. paratuberculosis,Clostridioides difficile CD8,Escherichia coli O111B4,Chlamydia muridarum,Moraxella catarrhalis,Mycobacterium sp.,Aeromonas veronii,Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Mus musculus,Rattus norvegicus,Influenza A virus,unidentified influenza virus,Trypanosoma cruzi,Toxoplasma gondii,Homo sapiens)
• Testing mTOR pathway active biomarkers in clear cell renal cell carcinoma: preferable methods to be used to stratify patients for more likely response to mTOR inhibitors (2014, NA)
• Proposed mechanism for SPRY1 promotion of lysosomal degradation of uPAR and inhibition of uPAR-mediated cell adhesion and proliferation (2014, NA)
• HER family and EGFR signaling pathway (2014, Homo sapiens)
• Kinetics of the GPCR interactome (2014, Escherichia coli,Escherichia coli KD1,Escherichia coli KD2,Homo sapiens,Kobus kob)
• Development of Spirodela dormancy through the signal transduction in response to environmental stimuli (2014, NA)
• 5-Lipoxygenase (5-LOX) pathway in mammalian cells (2014, NA)
• Biological activities of triterpenoids and saponins in animals (2014, NA)
• Rap1a in advanced glycation end product/the receptor for advanced glycation end product signaling (2014, NA)
• Putative mechanism for EGCG-conducted cardioprotection against H2O2-induced oxidative stress through the Akt/GSK-3B /caveolae pathways in cultured H9c2 cells (2014, NA)
• Notch–HER2 crosstalk in HER2+ BC (A) (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Human papillomavirus type 16)
• Notch–EGFR crosstalk in TNBC (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Human papillomavirus type 16)
• Notch receptor and pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Human papillomavirus type 16)
• HER receptor and pathway: (A) there are four members of the HER family of RTKs: EGFR/HER1, HER2, 3, and 4 (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Human papillomavirus type 16)
• BMP signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Hypothetical diagram of LPS-triggered inflammation and apoptosis pathways summarized in A (2014, NA)
• Diagram of putative mechanisms of GPR126 function in endothelial cells (2014, NA)
• Integration of the CTD, histone tails, and the hexosamine biosynthetic pathway (2014, NA)
• Abieslactone Induces Cell Cycle Arrest and Apoptosis in Human Hepatocellular Carcinomas through the Mitochondrial Pathway and the Generation of Reactive Oxygen Species (2014, NA)
• Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells (2014, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides)
• Top overlapped pathways for non-users (top) and users (bottom) of oral contraceptives.Notes: Hexagon shaped are genes (2014, Homo sapiens,Mus musculus)
• Transcriptome Profiles of the Protoscoleces of Echinococcus granulosus Reveal that Excretory-Secretory Products Are Essential to Metabolic Adaptation (2014, NA)
• Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra (2014, NA)
• SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies (2014, NA)
• Metacore analysis of leading edge genes (2014, Diaporthe sclerotioides,Helianthus annuus,Citrus macrophylla,Homo sapiens,Rattus norvegicus)
• Metacore analysis of leading edge genes (2014, Diaporthe sclerotioides,Helianthus annuus,Citrus macrophylla,Homo sapiens,Rattus norvegicus)
• Network enrichment analysis of point mutations in genome TCGA-02-0014 (2014, NA)
• Schematic presentation of mechanisms leading to cell cycle deregulation in growth plate dtd chondrocytes (2014, NA)
• Network of noncoding RNAs negatively regulates NFKB signaling (2014, NA)
• Neuroprotective functions of resveratrol in AD pathogenesis (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,prion)
• Most significant pathways identified by Ingenuity pathway analysis (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus,Eucalyptus intertexta)
• Wnt/Beta-catenin signaling pathway (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,Hippopotamus amphibius)
• Apoptosis signaling and cell death relevant drugs (2014, NA)
• Insulin signaling KEGG pathway in adipose tissue (2014, NA)
• Transcriptomic Immune Response of the Cotton Stainer Dysdercus fasciatus to Experimental Elimination of Vitamin-Supplementing Intestinal Symbionts (2014, Dysdercus fasciatus,Homo sapiens)
• Caspase-1 activation by inflammasomes leads to pro-inflammatory cytokine production: Inflammasomes can be triggered by various stimuli (2014, Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Caenorhabditis elegans,unidentified)
• Major signaling pathway regulation and core machinery of autophagy (2014, NA)
• TNF signaling network noise normalized to the noise that is contributed by the common TNF–TNFR segment, based upon the data in (2014, Homo sapiens,Mus musculus)
• Details of genes in the ‘acute phase response’ biological pathway identified in Ingenuity Pathway Analysis, which are differentially expressed in the frontal section of SHRSP vs. WKY rats at 5 weeks of age (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia phage T7)
• The binding sites on human epidermal growth factor receptor 2 (HER2) for FDA-approved HER2-directed therapies (2014, Homo sapiens)
• Representation of the molecular crosstalk between estrogen receptor and the receptor tyrosine kinases and PI3K-Akt-mTOR axes (2014, Homo sapiens)
• Possible mechanisms of expression and functional regulation of tissue factor and coagulation factor VII in breast cancer cells (2014, NA)
• Schematic summary of the molecular mechanisms of HLJ1 in suppressing lung cancer tumourigenesis (2014, NA)
• Mutant epidermal growth factor receptor endocytic trafficking (2014, NA)
• Intracellular estrogen receptor and epidermal growth factor receptor signaling pathway in non-small cell lung cancer (2014, NA)
• PI3K-AKT signaling KEGG pathway in adipose tissue (2014, NA)
• Schematic of how PDE5 inhibitors and DNA damaging drugs interact to kill T24 cells (2014, NA)
• High-confidence reaction map of the TSLP signaling pathway (2014, Homo sapiens,Mus musculus)
• PR pathways in eukaryotes (2014, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Glycine max,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences (2014, Homo sapiens,Mus musculus)
• Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways (2014, NA)
• AXL kinase as a novel target for cancer therapy (2014, Homo sapiens,Mus musculus)
• HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization (2014, Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,vectors,NA)
• Anti-tumor functions of GD T cells (2014, Homo sapiens,Hylobates sp.,Mus musculus,Human immunodeficiency virus 1)
• Epidermal growth factor receptor pathway (2014, Homo sapiens)
• Schematic presentation of the pathways involved in the inflammatory response during acute pancreatitis (2014, Homo sapiens)
• The PI3K/mTOR signaling pathway upon stimulation with growth factors, with an emphasis on the phosphoregulation of PRAS40 (2014, NA)
• Major crosstalks between the PI3K and the MAPK cascades (2014, NA)
• Ras/MAPK signaling (2014, NA)
• Canonical Wnt signaling (2014, NA)
• PI3K signaling (2014, NA)
• Accounting for eXentricities: Analysis of the X Chromosome in GWAS Reveals X-Linked Genes Implicated in Autoimmune Diseases (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,Theria)
• In silico modeling of a CD4+ T-cell (2014, NA)
• Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment (2014, NA)
• A, Cellular arginine metabolism and putative role of arginase in the development of renal fibrosis (2014, NA)
• Acetylation of metabolic enzymes in M (2014, Mycobacterium tuberculosis)
• The signaling pathways affected by Syk that drive AB production, neuroinflammation, and Tau hyperphosphorylation (2014, NA)
• Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway (2014, Saccharomyces cerevisiae,Candida dubliniensis,Sequoia sempervirens,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Venustaconcha ellipsiformis,Mycobacterium tuberculosis SP5)
• RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities (2014, Gallus gallus,Danio rerio,Oryzias latipes,Homo sapiens,Mus musculus,Galatella linosyris)
• CED-3-activated suppression of AKT signaling by CNT-1 (2014, Homo sapiens,Caenorhabditis elegans)
• Redox-Mediated and Ionizing-Radiation-Induced Inflammatory Mediators in Prostate Cancer Development and Treatment (2014, NA)
• Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study (2014, NA)
• Canonical and non-canonical TGFB signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Signaling pathways: HN exerts its function through both extracellular receptors and intracellular binding partners (2014, NA)
• Scheme of metabolic pathways where enzymes upregulated in specific growth phase during antibiotic production are highlighted (2014, Saccharopolyspora spinosa,Homo sapiens)
• Induction of nuclear factor-activated T cells c1 (NFATc1) in osteoclasts (2014, NA)
• C-peptide-initiated signaling cascades (2014, NA)
• The signaling cascade regulating steroidogenic acute regulatory (StAR) gene transcription (2014, Rattus norvegicus,Homo sapiens)
• Insights into Molecular Features of Venerupis decussata Oocytes: A Microarray-Based Study (2014, NA)
• HMGB1 Promotes a p38MAPK Associated Non-Infectious Inflammatory Response Pathway in Human Fetal Membranes (2014, NA)
• Control of the concentration of transcripts for enzymes involved in central carbon metabolism (2014, Escherichia coli)
• Proposed mechanisms underlying TMZ-mediated regulation of GCs migration. In GBM cells, WNK1 and OSR1 are the major kinases regulating NKCC1 activity under physiological condition and in the presence of TMZ treatment (2014, Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Network of interactions between products of candidate genes from the QTL regions (2014, Eimeria tenella,Homo sapiens)
• MTOR pathway signaling pathway (2014, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Saccharomyces cerevisiae,Armoracia rusticana,Cinchona pubescens,Homo sapiens,Drosophila melanogaster,Capra hircus,Xenopus laevis)
• T cell PPI Network mapped to TCR, with main JAK-STAT and MAPK signaling pathways (2014, Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Bacillus subtilis,Corynebacterium phage gamma,Leuciscus leuciscus)
• Ingenuity Pathway Analysis (IPA) of the 39 differentially expressed genes in MFG transcriptome at 18 hpi vs (2014, NA)
• Neuronal circuit diagram of the light input pathway in the tadpole retina (2014, NA)
• IPA graphic representation of the network “Cell death and survival, DNA replication, recombination, and repair, cellular response to therapeutics”. Nodes represent genes and lines show the relationship between genes (2014, NA)
• Genes in cancer-related pathways (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Hepatitis B virus,clinical samples,Eucalyptus intertexta,NA)
• LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/Beta-catenin signaling pathway (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana,Human papillomavirus)
• Prolactin induces up-regulation of its cognate receptor in breast cancer cells via transcriptional activation of its generic promoter by cross-talk between ERA and STAT5 (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer (2014, NA)
• Canonical Wnt signaling () (2014, NA)
• Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis (2014, Homo sapiens,Mus musculus)
• Genetics of lymphatic anomalies (2014, NA)
• Comparative Genomic and Transcriptomic Analyses of LNCaP and C4-2B Prostate Cancer Cell Lines (2014, Homo sapiens,Mus musculus,Bos taurus)
• Insulin/IGF-1 signaling and regulation (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Coregonus peled)
• A, JAK-STAT signaling pathway in interaction network (2014, NA)
• Protective Efficacy of Vitamins C and E on p,p′-DDT-Induced Cytotoxicity via the ROS-Mediated Mitochondrial Pathway and NFKB/FasL Pathway (2014, Armoracia rusticana,Vitis vinifera,Sophora flavescens,Mus musculus,Rattus norvegicus,Dipturus trachyderma,Oreochromis niloticus,Homo sapiens,Oryctolagus cuniculus,environmental samples)
• Identification of MicroRNAs Linked to Regulators of Muscle Protein Synthesis and Regeneration in Young and Old Skeletal Muscle (2014, NA)
• Involvement of CD81 in Hepatitis C Virus (HCV) lifecycle (2014, NA)
• Synthetic Alpha-Bromo-2′,3,4,4′-Tetramethoxychalcone (Alpha-Br-TMC) Inhibits the JAK/STAT Signaling Pathway (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Calcitonin Gene-Related Peptide Regulates Cardiomyocyte Survival through Regulation of Oxidative Stress by PI3K/Akt and MAPK Signaling Pathways (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus,Allium tricoccum)
• Simplified diagram of the mammalian target of rapamycin (mTOR) signaling pathway and its relationship with autophagy and apoptosis (2014, NA)
• Canonical pathway of TP53 signaling: dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) (2014, NA)
• Dataset was analyzed with the IPA software (Ingenuity Systems®, www.ingeuity.com) (2014, NA)
• Differential Apoptosis in Mucosal and Dermal Wound Healing (2014, Mus musculus,Homo sapiens)
• Cytokine signaling pathways in brain preconditioning (2014, Mus musculus,Rattus norvegicus,Candida dubliniensis,Candida albicans,Homo sapiens,Drosophila melanogaster,Sus scrofa,Anas platyrhynchos)
• TLR signaling pathways in cerebral IT (2014, Mus musculus,Rattus norvegicus,Candida dubliniensis,Candida albicans,Homo sapiens,Drosophila melanogaster,Sus scrofa,Anas platyrhynchos)
• MAVS filaments and activation of the IFN-I pathway (2014, Homo sapiens,prion,NA)
• Proposed new mechanism for regulation of PI3K–Akt–FoxO pathway by Trim32 (2014, NA)
• Cell cycle regulation by p16Ink4b/p14ARF (2014, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Insulin- and IGF-1-signaling pathways (2014, NA)
• Endocytosis in neurons (2014, NA)
• Methylation Matters In KRAS Oncogenesis (2014, Homo sapiens,Mus musculus)
• MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells (2014, Bos taurus,Sus scrofa,Homo sapiens,Mus musculus)
• Working hypothesis of IRS-mediated control of protein synthesis (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Betapolyomavirus macacae,JC polyomavirus,Homo sapiens,Saccharomyces cerevisiae,vectors)
• Inflammation on bone (2014, Homo sapiens,Mus musculus,Pneumocystis jirovecii)
• Illustration of the proposed crosstalk between insulin/IGF1 and IL-17 signaling pathways (2014, NA)
• Glycerol metabolic pathway in the engineered PM1 strain (2014, Escherichia coli,Limosilactobacillus panis)
• The UPR-induced HAdV infection boost by GCA (2014, NA)
• Top Ingenuity networks of genes whose expression was significantly altered in the hippocampus upon FST exposure (2014, NA)
• Proposed model for the control of Beta-catenin stability by RNF220/USP7 (2014, NA)
• Model depicting the molecular mechanism involved in counterregulation of TLR-induced inflammatory signature by dectin-1 (2014, NA)
• KLF4-dependent miRs cooperatively promote RAS-ERK pathway activity by cotargeting of pathway inhibitors (2014, NA)
• ‘Ephrin Receptor Signaling’ was the second canonical IPA pathway induced in LR rats upon FST exposure (2014, NA)
• Hypothetical model for BNF-induced cell cycle arrest and senescence (2014, NA)
• Mechanism of oestrogen action (2014, NA)
• The NAD pathway model (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Macaca mulatta,Pan troglodytes,Arabidopsis lyrata,Mus musculus castaneus,Drosophila melanogaster,Drosophila yakuba,Canis lupus familiaris,Lavinia exilicauda)
• The regulation of Nedd4-1 by the PI3K/PTEN-mTORC1 signaling pathway during neurite growth (2014, Homo sapiens,Mus musculus)
• Cholesterol metabolism, lipid rafts and cellular prion propagation (2014, NA)
• Mosquito immune signaling and RNAi pathways (2014, Dengue virus,Vesicular stomatitis virus,West Nile virus,Japanese encephalitis virus,Sindbis virus,Chikungunya virus,Ebola virus sp.,Dengue virus type 2,Semliki Forest virus,Rift Valley fever virus,Venezuelan equine encephalitis virus,Dengue virus group,Flock House virus,Drosophila C virus,Cricket paralysis virus,Drosophila melanogaster,Plasmodium falciparum,Aedes aegypti,Anopheles gambiae,Aedes albopictus,Culex quinquefasciatus,Anopheles quadrimaculatus,Ixodes ricinus,Dermatophagoides pteronyssinus,Saccharomyces cerevisiae,Glycine max,Homo sapiens,Pantoea agglomerans,NA)
• NLRP3 regulation by GPSM3 (2014, NA)
• Insulin signaling network (2014, Homo sapiens)
• Evolution of a Cellular Immune Response in Drosophila: A Phenotypic and Genomic Comparative Analysis (2014, NA)
• The molecular mechanisms and pathways of BBR in reducing oxidative stress and inflammation (2014, Mus musculus,Rattus norvegicus,Coptis chinensis,Cinchona pubescens,Homo sapiens,Triportheus paranensis,Corynephage beta)
• The secretory pathways used by NMDARs (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Corynocarpus laevigatus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Signaling pathways of TRKA activation by NGF (2014, NA)
• Intracellular signaling pathways that mediate early and late biphasic changes in paracellular claudin-5 expression (2014, Mus musculus,Homo sapiens)
• Valsartan independent of AT1 receptor inhibits tissue factor, TLR-2 and-4 expression by regulation of Egr-1 through activation of AMPK in diabetic conditions (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Effects of GB88 on PAR2-mediated signalling (2014, NA)
• Proposed mechanism by which the AMPK signalling pathway regulates BP in the NTS of rats with fructose-induced hypertension (2014, Rattus norvegicus,Homo sapiens)
• Cyclooxygenase and 5-lipoxygenase pathways with special reference to aspirin exacerbated respiratory disease (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular mechanisms of Bcl-6 expression in T cells (2014, NA)
• Mechanism of hepatic insulin resistance and the key pathway of drug action (2014, NA)
• Regulatory network of cell-fate decision upon DNA damage involving (A) the G1/S checkpoint arrest network and (B) the senescence regulatory pathway (2014, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• Arachidonic acid (AA) release and action (2014, NA)
• Simplified schematic diagram of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway and proposed cellular regulation of muscle protein synthesis in response to hypoxia, caloric restriction, insulin, muscle contraction, and leucine (2014, Saccharomyces cerevisiae,Theobroma cacao,Homo sapiens,Rattus norvegicus,Gallus gallus,unidentified)
• Anti-Inflammatory Strategies in Cartilage Repair (2014, NA)
• Schematic review (2014, Homo sapiens)
• miR501-5p functions as a balance in the modulation of cell survival and apoptosis in clear cell renal carcinoma (2014, NA)
• Coordination of macrophage-mediated signaling and muscle regeneration (2014, NA)
• Activation of growth factor receptor protein tyrosine kinases results in autophosphorylation on tyrosine residues (2014, Homo sapiens)
• Canonical and non-canonical JAK-STAT pathway and its subversion by BCR-ABL or mutant KIT (2014, Homo sapiens)
• Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet (2014, NA)
• Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet (2014, NA)
• Injury-induced signaling in Trichoderma atroviride (2014, NA)
• Effects of renal ectonucleotidases and consequences for activation of purinoceptor subtypes (2014, NA)
• The putative gluconeogenesis pathway in Leishmania promastigotes (A) and amastigotes (B) suggested in this study (2014, Leishmania mexicana,Homo sapiens)
• Molecule-mediated signal pathways in the propagation of liver cancer during liver regeneration (2014, NA)
• Hepatitis C virus replication cycle (2014, NA)
• Role of purinergic receptors in regulation of insulin secretion and Beta-cell survival (2014, Homo sapiens)
• Activation of the PKA pathway in the presence of glucose by different essential nutrients through multiple transceptors (2014, NA)
• Nutrient sensing by transporter-like plasma membrane sensors (2014, NA)
• Glucose activation of the cAMP-PKA pathway (2014, NA)
• Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae (2014, NA)
• Complement-induced inflammation pathway: an important mediator of neuroinflammatory processes from M4 onwards (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Equus caballus)
• Control of synaptic function by endocannabinoid-mediated retrograde signaling (2014, Mus musculus,Rattus norvegicus,Olea europaea,Cannabis sativa,Homo sapiens,Canis lupus familiaris)
• Control of synaptic function by endocannabinoid-mediated retrograde signaling (2014, Mus musculus,Rattus norvegicus,Olea europaea,Cannabis sativa,Homo sapiens,Canis lupus familiaris)
• Signaling pathway of toll-like receptors (TLRs) (2014, Helicobacter pylori,Streptococcus pneumoniae,Porphyromonas gingivalis,Neisseria meningitidis,Streptococcus sp. group B,Leptospira interrogans,Treponema maltophilum,Mouse mammary tumor virus,Respiratory syncytial virus,ssRNA viruses,dsRNA viruses,Homo sapiens,Mus musculus,Trypanosoma cruzi)
• Survival tree analysis of significant SNPs associated with NSCLC survival identified from the single SNP analysis (q<0.10) in our initial cohort (2014, Homo sapiens,unidentified,Bikinia letestui)
• Hypoxia promotes pancreatic cancer initiation, progression, and metastasis through the activation of NFKB-RAGE-KRAS-HIF1A pathway (2014, NA)
• Diagram showing that radioresistance is associated with repression of apoptosis pathway by upregulation of Bcl-XL and Bcl-2 and downregulation of Caspase-3, Caspase-7, Cleaved PARP and Bax in CaP-RR cells (2014, NA)
• PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways (2014, NA)
• PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways (2014, NA)
• Canonical and non-canonical Wnt pathways exert opposite effects on the formation of the vertebrate NMJ (2014, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Homo sapiens,Agaricus bisporus)
• Proposed mechanism for miR-155-mediated myeloid leukemogenesis (2014, Human gammaherpesvirus 4,Avian leukosis virus,Homo sapiens,Mus musculus,Gallus gallus)
• Proposed model of hypoxia-induced cellular processes presumably leading to antifolate resistance (2014, Homo sapiens,Cricetulus griseus)
• Largest key pathway obtained for the colorectal cancer case study (2014, NA)
• Proposed model for miR-542-3p-mediated suppression of osteoblast proliferation and differentiation (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,vectors,Butea monosperma)
• Genes for which a correlation with Wnt/Beta-catenin signaling was indicated by MetaCore pathway analysis (2014, NA)
• Molecular mechanisms linking ROS, antioxidants, and the insulin signalling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Circadian pathways (2014, Homo sapiens,Mus musculus)
• CXCL12 chemokine signaling (2014, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Solanum lycopersicum,Xenopus laevis)
• Simplified scheme of the HIF signalling pathway (2014, NA)
• Computational simulation of eicosanoid profile in ATP-stimulated BMDM (2014, NA)
• Summary of myocardial cellular effects and the injury response induced by anthracyclines (2014, Homo sapiens)
• Proposed model for the regulation of mTOR signaling in conditions of overnutrition and the cardiorenal syndrome (CRS) (2014, NA)
• Modules identified by functional and gene expression enrichment analysis (2014, NA)
• Pathway analysis highlights opposing regulation of a DNA repair pathway in radioresistant versus radiosensitive cells (2014, NA)
• The IGF1R/mTOR signaling pathway resulting in growth and survival of the cell (2014, Homo sapiens)
• Host response profile of human brain proteome in toxoplasma encephalitis co-infected with HIV (2014, NA)
• Additional functional modules identified by ingenuity pathway analysis (2014, NA)
• E2F2 Transcription Factor Sustains Hepatic Glycerophospholipid Homeostasis in Mice (2014, NA)
• Proposed working model (2014, NA)
• BMP Family and Signaling Pathways (2014, NA)
• The autocrine and paracrine effects of WISP2 (2014, NA)
• Proposed signaling pathway of ITPs in B (2014, Bombyx mori)
• Metabolic and transcriptional profiles for components of the TCA cycle (A) and BCAA biosynthetic pathway (B) (2014, Saccharomyces cerevisiae,Homo sapiens)
• LPA-dependent platelet-induced tumor cell metastasis (2014, Homo sapiens,Mus musculus)
• Hypothetical representation of PI3K/AKT/PTEN signaling in pancreatic Beta-cells is shown, which modulate NOXs-derived reactive oxygen species (ROS) generation (2014, NA)
• Expression and function of K+ channels in sensory neurons (2014, Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens,Mustela lutreola)
• The role of Pkp3 in cell–cell junction formation (2014, NA)
• Compounds used as anti-fibrotic therapies in other organs and their mode of action (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• In addition to the known pathways that activate hepcidin expression, we show that Ras/RAF-triggered signals and the mTOR pathway are involved in hepcidin suppression (2014, NA)
• Shed Sdc-1 induces the activation of EGFR and downstream signalling pathways via sHB-EGF (2014, NA)
• Pancreatic cancer cell survival pathways in 5-fluorouracil resistance (2014, NA)
• Outline of the targeted therapies, which are currently available or under development for the treatment of hepatocellular carcinoma, and the molecular targets on which they are believed to act upon (2014, NA)
• Toxicity and adaptive response pathways, as derived from linking transcriptome and proteome responses to physiological effects (2014, Chlamydomonas reinhardtii)
• Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat (2014, NA)
• Pathway Based Analysis of Genes and Interactions Influencing Porcine Testis Samples from Boars with Divergent Androstenone Content in Back Fat (2014, NA)
• Oxidative stress-induced pathways of pPROM and spontaneous PTB with intact membranes (2014, NA)
• A proposed model for the rat medicated serum containing YGW on oocyte maturation and subsequent fertilization competence (2014, Eucommia ulmoides,Achyranthes bidentata,Cuscuta chinensis,Mus musculus,Rattus norvegicus,Homo sapiens,Moloney murine leukemia virus)
• Wnt signaling pathway and its key components (2014, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis)
• Scheme depicting the inhibition of smooth muscle contraction via CB1 receptors (2014, Oryctolagus cuniculus,Homo sapiens)
• Potential signaling mechanisms mediating enhanced G protein-coupled receptor (GPCR)-induced vasoconstriction of resistance arteries from Eln+/− mice (2014, NA)
• Erythropoietin receptor and signaling pathways (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• Enzymatic reactions catalyzed by PLD (2014, Mus musculus,Rattus norvegicus,Ovis aries,Mustela putorius furo,Homo sapiens,Drosophila melanogaster,NA)
• Cellular defense mechanisms induced by IPNV infection in CHSE-214 cells (2014, Danio rerio,Oncorhynchus mykiss,Salmo salar,Dipnomorpha,salmonid fish,Anguilla japonica,Oncorhynchus tshawytscha,Influenza A virus,Encephalomyocarditis virus,Infectious pancreatic necrosis virus,Salmonid alphavirus subtype 3,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Armoracia rusticana,NA,NA)
• TCDD induced HIF-1A molecular signaling (2014, NA)
• Pathway analysis (2014, Carex media,Cycas media subsp. media,Homo sapiens,Rattus norvegicus)
• CD147 plays an important role in a variety of cells and tissues regardless of health or disease (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Gallus gallus,Plasmodium falciparum,Human gammaherpesvirus 8,Neisseria meningitidis,NA,NA)
• Proposed model of the roles of CDKN1A and KIF20A in cell cycle control via RB/E2F pathway (2014, NA)
• Syn mechanisms of action (2014, NA)
• Schematic presentation of the signaling pathways involved in CAPE-induced apoptotic pathway in C6 glioma cells (2014, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Armoracia rusticana,Human immunodeficiency virus 1)
• Development of mononuclear phagocytes (2014, Mus musculus,Homo sapiens)
• Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma (2014, Homo sapiens,Mus musculus,Bos taurus,murine stem cell retroviral vector,NA)
• Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease (2014, Homo sapiens,Mus musculus,Bos taurus)
• IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop (2014, NA)
• Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1A Protein Synthesis (2014, NA)
• Salt-Inducible Kinase 1 (SIK1) Is Induced by Gastrin and Inhibits Migration of Gastric Adenocarcinoma Cells (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Targeting the estrogen pathway for the treatment and prevention of lung cancer (2014, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Model highlighting the possible function and position of heat-induced among the key players of the -mediated heat-signaling pathway, elicited by the plasma membrane during HS (2014, Arabidopsis thaliana)
• Cascade of arachidonic acid (AA) (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Damage-associated molecular pattern signaling mechanisms (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• VEGFR2/NAADP/TPC2/Ca2+signaling pathway in the control of VEGF-induced angiogenic responses (2014, NA)
• Up-regulation of the type I IFN canonical pathway by IFNB treatment (2014, NA)
• Mycobacterium tuberculosis (M.tb) drives matrix metalloproteinase (MMP) secretion by direct effects and intercellular networks (2014, NA)
• Interaction between human GD T cell and tumor cell (2014, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,Human betaherpesvirus 5,West Nile virus,Simian immunodeficiency virus,Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis,Escherichia coli WC1,Homo sapiens,Mus musculus,Bos taurus,Plasmodium falciparum,Cryptococcus neoformans var. grubii H99)
• Statistically significant signaling pathway networks between JU and vehicle groups (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Venustaconcha ellipsiformis)
• Interactions of Acvr1b with other proteins in primary infection (2014, NA)
• Proposed pathway for the mechanism of shear stress-induced NO (2014, NA)
• Postulated molecular regulation of eukaryotic elongation factor-2 kinase (eEF-2K)/TG2 pathway to the invasion-promoting signalling in pancreatic cancer (PaCa) cells (2014, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,vectors)
• Proposed pathway of the antioxidative effects of AST through the mitochondrion-mediated signalling pathway of apoptosis (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Respiratory syncytial virus)
• miR-18a Inhibits CDC42 and Plays a Tumour Suppressor Role in Colorectal Cancer Cells (2014, NA)
• The PdfR signaling pathway (2014, NA)
• Alcohol and the toxic effects in vivo leading to developmental defects (2014, Homo sapiens)
• Hippo pathway controls the migration of border cell clusters through two mechanisms (2014, NA)
• Complement system: an overview (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Lareunionomyces loeiensis)
• Global picture of glucose–insulin dynamics (2014, NA)
• Identification of Distinct Glycoforms of IgA1 in Plasma from Patients with Immunoglobulin A (IgA) Nephropathy and Healthy Individuals (2014, NA)
• Cellular pathways of prostaglandin (PG) metabolism (2014, Armoracia rusticana,Postia placenta,Homo sapiens,Rattus norvegicus)
• Schematic diagram indicating a hypothesis of the mechanism of GnT-V expression regulating colon tumor development (2014, Mus musculus,Homo sapiens)
• Concerted regulation of NFATc3 by electrical activity and NGF in sensory neurons (2014, NA)
• Reversibility of phospho-Smad3 signaling between tumor suppression and fibro-carcinogenesis (2014, Homo sapiens)
• Epithelial AvB3-Integrin Boosts the MYD88-Dependent TLR2 Signaling in Response to Viral and Bacterial Components (2014, Armoracia rusticana,Candida dubliniensis,Human alphaherpesvirus 1,Human alphaherpesvirus 2,Homo sapiens,Mus musculus,Bos taurus,NA)
• In Vitro, In Silico and In Vivo Studies of Ursolic Acid as an Anti-Filarial Agent (2014, NA)
• Clinical utility of pharmacogenomics in the management of hepatitis C (2014, Human immunodeficiency virus,Non-A non-B hepatitis virus,Hepatitis C virus genotype 1,Hepatitis C virus genotype 2,Homo sapiens,NA)
• Clinical utility of pharmacogenomics in the management of hepatitis C (2014, Human immunodeficiency virus,Non-A non-B hepatitis virus,Hepatitis C virus genotype 1,Hepatitis C virus genotype 2,Homo sapiens,NA)
• RAS signaling pathway and genes mutated in juvenile myelomonocytic leukemia (in black) (2014, Homo sapiens)
• P-21 activated kinase (PAK)1 in canonical and non-canonical NFKB signalling (2014, NA)
• Sensing of transferrin-bound iron and regulation of hepcidin expression in hepatocytes (2014, NA)
• LFG-500 Inhibits the Invasion of Cancer Cells via Down-Regulation of PI3K/AKT/NFKB Signaling Pathway (2014, NA)
• Selective autophagy in respiratory infection and sepsis (2014, Mycobacterium tuberculosis,Homo sapiens)
• Excess glucose and fatty-acid exposure linked to reduction of AMPK and consequent inflammation and fibrosis (2014, Homo sapiens,Mus musculus)
• Representation of IL-33 pathway in T-helper cells (2014, Homo sapiens,Mus musculus)
• Causal gene network inferred from top discriminative modules at a significance level of 0.005 (2014, NA)
• Wnt signaling pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Regulation and effects of JNK signaling in hepatocytes (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• New miRNA Profiles Accurately Distinguish Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas from the Normal Kidney (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Armoracia rusticana,Matthiola incana,Iris germanica,Homo sapiens,Mus musculus,Escherichia coli)
• Shigella dysenteriae Modulates BMP Pathway to Induce Mucin Gene Expression In Vivo and In Vitro (2014, NA)
• Two potential mechanisms of honokiol regulation of Notch ligands (2014, Danio rerio,Xenopus laevis,Homo sapiens,Magnolia officinalis)
• Honokiol and ionizing radiation (IR) affect Notch signaling (2014, Danio rerio,Xenopus laevis,Homo sapiens,Magnolia officinalis)
• Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice (2014, NA)
• Working hypotheses to trigger nuclear Ca2+Different pathways to generate nuclear Ca2+ signals have been proposed (2014, NA)
• Majority of mitochondrial proteins/enzymes undergo reversible lysine acetylation (2014, NA)
• Mechanism and Role of AMPK activation (2014, Mus musculus,Rattus norvegicus,Syringa vulgaris,Galega officinalis,Homo sapiens)
• ANP/BNP and CNP bind cell surface receptors called NPR-A and NPR-B, respectively, which have an intracellular catalytic domain with guanylyl cyclase activity (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens)
• Cartoon depicting the major pathway by which a pancreatic beta cell secretes insulin in response to increases in plasma glucose (2014, NA)
• CaSR-mediated control of ion transport across the thick ascending limb (2014, Homo sapiens)
• The molecular cascade downstream of Nodal and Activin A signalling in EpiSCs (2014, NA)
• TGFB signalling pathway in the early mouse embryo (2014, Mus musculus,Homo sapiens)
• MicroRNA Network Dysregulated in Asthma Controls IL-6 Production in Bronchial Epithelial Cells (2014, NA)
• Wnt/Beta-Catenin Signaling Modulates Human Airway Sensitization Induced by B2-Adrenoceptor Stimulation (2014, Homo sapiens,Mus musculus,Bos taurus,Lareunionomyces loeiensis,Antarctothoa delta)
• Hormonal Induction and Roles of Disabled-2 in Lactation and Involution (2014, NA)
• Polymorphisms of an Innate Immune Gene, Toll-Like Receptor 4, and Aggressive Prostate Cancer Risk: A Systematic Review and Meta-Analysis (2014, Homo sapiens,Mus musculus,Betapolyomavirus hominis,Pieris rapae)
• Epidermal Growth Factor Receptor Family and intracellular pathway (adapted from http://nature.com ) (2014, NA)
• KEGG B cell signaling pathway after tissue specific and PPI-based tuning in CD19 B cells (2014, Homo sapiens,Mandrillus leucophaeus)
• KEGG B cell signaling pathway tuned in CD19 B cells and CD4 T cells (2014, Homo sapiens,Mandrillus leucophaeus)
• Visualization of KEGG B Cell Receptor Signaling Pathway after parsing and automatic correction (2014, Homo sapiens,Mandrillus leucophaeus)
• Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy (2014, NA)
• Schematic diagram to illustrate the ubiquitination of IRE1 by CHIP and the effect to the relevant signaling (2014, NA)
• miR-305 targets in ISC self -renewal and differentiation (2014, Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus)
• Protein trafficking of pericellular proteases (2014, Homo sapiens,Mus musculus,Bacillus anthracis)
• Transcription Factor Ste12 Mediates the Regulatory Role of the Tmk1 MAP Kinase in Mycoparasitism and Vegetative Hyphal Fusion in the Filamentous Fungus Trichoderma atroviride (2014, Trichoderma atroviride,Homo sapiens)
• Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma (2014, NA)
• Network-Based Classification Model for Deriving Novel Drug-Disease Associations and Assessing Their Molecular Actions (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Gallirallus australis)
• De Novo Mutations in Moderate or Severe Intellectual Disability (2014, Homo sapiens,Mus musculus)
• Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut (2014, NA)
• Activation of mammalian target of rapamycin occurs through a complex signaling cascade (2014, Homo sapiens,Mus musculus)
• Simplified model of the potential contributions of selective sensors and cell types to IFN production during viral infections (2014, Homo sapiens)
• Schematic diagram shows that CBHA abrogates TNF-Alpha-induced PAI-1 expression in human pleural mesothelial cells through enhancement of MKP-5/MKP-1 expression and repression of MAPK/AP-1 signal pathway (see test for further explanation) (2014, NA)
• Schematic diagram showing clathrin mediated endocytosis of KSHV in HFF cells (2014, NA)
• Model depicting Tax-induced shuttling, localization and activation of canonical and noncanonical NFKB signaling pathways (2014, Human T-cell leukemia virus type I,Human T-lymphotropic virus 2,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Signaling changes in the T-Cell receptor signaling pathway of human bone marrow hematopoietic stem cells (2014, NA)
• Signaling changes in mouse models of obesity (2014, NA)
• This figure illustrates some of the mechanisms by which CD40L can influence on different cell functions and the processes by which these altered cells can impact on host immunity in neoplastic diseases (2014, NA)
• Schematic model of Wnt- and SHH pathways working interdependently in GBM based upon observations in this study (2014, Homo sapiens)
• Sphingolipid metabolism (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Mammary cell involution in response to stretch (2014, Homo sapiens)
• B cell receptor signalling pathway controls B-cell fate and function (2014, NA)
• PKCD and θ Possibly Mediate FSH-Induced Mouse Oocyte Maturation via NOX-ROS-TACE Cascade Signaling Pathway (2014, NA)
• EMT-associated signaling molecules in glioma cell (2014, NA)
• PI3K/PTEN–mTOR pathway (2014, NA)
• PrPCsignaling via SFKs (2014, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio,Canis lupus familiaris,prion,Morchella esculenta,NA)
• EGFR-axis pathway that contributes to cyst formation and progressive enlargement in ADPKD and ARPKD (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• DAPK2 is a novel modulator of TRAIL-induced apoptosis (2014, Homo sapiens)
• Possible roles of Hsp90 in AD (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Regulation of TFs activity by degradation modulated by H2O2 (2014, NA)
• The results described in this study linking Ras signaling to p53 inactivation in cell cycle control (2014, NA)
• Chemical signaling schemas (2014, Oryctolagus cuniculus,Canis lupus familiaris,PX clade,Chlamydomonas reinhardtii,Homo sapiens,Mus musculus,Adeno-associated virus,Conus striatus)
• New concept of signaling pathway of Glucagon‐like peptide‐1 (GLP‐1) (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Insulin signaling pathway (2014, NA)
• Canonical Wnt B catenin signaling pathway (2014, Homo sapiens)
• Cutting the brakes and flooring the gas: how TMEPAI turns TGFB into a tumor promoter (2014, NA)
• Working model to explain the antidiabetic effect of ADV36 (2014, Homo sapiens,Adenoviridae)
• Insulin-like growth factor-I receptor signaling pathway (2014, NA)
• Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Diabetes Recovery By Age-Dependent Conversion of Pancreatic D-Cells Into Insulin Producers (2014, NA)
• Mechanisms underlying the inhibition of interferon signaling by viruses (2014, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human papillomavirus,Dengue virus,Respiratory syncytial virus,Human papillomavirus type 16,Human gammaherpesvirus 8,Vaccinia virus,West Nile virus,Enterovirus C,Measles morbillivirus,Japanese encephalitis virus,Murid betaherpesvirus 1,Porcine reproductive and respiratory syndrome virus,Lyssavirus rabies,Ebola virus sp.,Foot-and-mouth disease virus,ssRNA viruses,Human metapneumovirus,Hepatovirus A,African swine fever virus,Influenza B virus,Kunjin virus,New world arenaviruses,Toscana virus,Mus musculus,Cricetus cricetus,Homo sapiens,Bos taurus,Drosophila melanogaster,NA,NA,NA,NA,NA,NA,NA)
• Macroautophagy in the immune system (2014, NA)
• Macroautophagy is regulated by several signalling pathways (2014, NA)
• Gene association network (GAN) 3 in lung (2014, NA)
• ER stress response mechanisms in the pathogenic yeast Candida glabrata and their roles in virulence (2014, NA)
• Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells (2014, NA)
• Heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway (2014, NA)
• Dextromethorphan Mediated Bitter Taste Receptor Activation in the Pulmonary Circuit Causes Vasoconstriction (2014, NA)
• HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Danio rerio)
• Proapoptotic signalling pathways activated in NGF-deprived sympathetic neurons (2014, NA)
• Survival pathways activated by the binding of NGF to TrkA (2014, NA)
• Hypothetical scheme of cGMP- and cAMP-mediated pathways in hippocampal memory consolidation processes (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathways Modulating GLI1-expression/activity in Cancer (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Olea europaea)
• Diagram showing signal pathways for EGFR transactivation in response to 3 mM NH4Cl (2014, NA)
• Tissue-specific regulation represented by putative functional regulatory networks (top: liver; bottom: muscle) (2014, NA)
• Endothelium-derived relaxing factors of small resistance arteries in normotensive and hypertensive conditions (2014, NA)
• Tissue-specific expression within individual functions—a case of insulin signaling pathway (2014, NA)
• Signaling control of CAR activation (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic comparing signaling cascades activated by EPO in microglia and macrophages (2014, NA)
• Regulation of MMP-9, MMP-13 and EMMPRIN by curcumin (2014, Mus musculus,Rattus norvegicus,Candida dubliniensis,Curcuma longa,Homo sapiens,Oryctolagus cuniculus)
• Crosstalk between signaling pathways implicated in pathogenesis of neuropsychiatric diseases (2014, NA)
• PTCH inhibits SMO and the hedgehog signaling pathway (2014, NA)
• Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax (2014, NA)
• Long-HER Study: Clinical and Molecular Analysis of Patients with HER2+ Advanced Breast Cancer Who Become Long-Term Survivors with Trastuzumab-Based Therapy (2014, Homo sapiens)
• Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment (2014, Homo sapiens)
• Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment (2014, Homo sapiens)
• KIAA1524/CIP2A promotes cancer growth by coordinating the activities of MTORC1 and MYC (2014, NA)
• Dark side of Toll-like receptor signaling (2014, NA)
• Glycolysis and gluconeogenesis in the aerobic thermoacidophile Sulfolobus solfataricus (2014, NA)
• Glycolysis and gluconeogenesis in the mesophilic halophile Haloferax volcanii (2014, NA)
• RANK signaling pathways (2014, NA)
• Shared sub-graphs at the intersection of distinct Pathway Commons resources (2014, NA)
• Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1A under nutrient deprivation (2014, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Human gammaherpesvirus 4,Moloney murine leukemia virus,Homo sapiens,Saccharomyces cerevisiae)
• Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk (2014, Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Vasconcellea candicans,Calloplesiops altivelis)
• Structural basis for cancer treatment decisions (2014, Homo sapiens,Human T-cell leukemia virus type I)
• Structural basis for cancer treatment decisions (2014, Homo sapiens,Human T-cell leukemia virus type I)
• Altered Mucins (MUC) Trafficking in Benign and Malignant Conditions (2014, NA)
• IFN-Beta-mediated regulation of PI3K/Akt/mTOR signaling and pharmacological agents active in this pathway (2014, NA)
• Proposed model depicting the role of IFI35 in negative regulation of RIG-I signaling (2014, NA)
• Integrated microRNA and mRNA Transcriptome Sequencing Reveals the Potential Roles of miRNAs in Stage I Endometrioid Endometrial Carcinoma (2014, NA)
• Schematic model of how SH2B1B enhances gene expression and neuronal differentiation through STAT3 (step 1) (2014, Homo sapiens,Chlorocebus aethiops,Rattus norvegicus)
• Wnt/Beta-catenin signaling pathways and a strategy for the phenotype-based drug identification using C (2014, Caenorhabditis elegans,Homo sapiens)
• Biochemical and genetic processes in malignant mesothelioma (2014, Homo sapiens,Mus musculus,Betapolyomavirus macacae,Pimelodus grosskopfii)
• COX-1-mediated PGE2 production in response to HP-PRRSV infection (2014, NA)
• Schematic presentation of the signaling pathways involved in H (2014, NA)
• Current strategies to generate tolDCs (2014, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Bursera graveolens,Homo sapiens,Bacillus subtilis)
• Production of salidroside in metabolically engineered Escherichia coli (2014, Escherichia coli,Homo sapiens)
• Proposed signal transduction pathway and feedback control for iron-inducible nuclear influx of Myb3 (2014, NA)
• Simplified interaction map between the LOXL4 protein with the OS pathway by both protein-protein interaction analysis and literature mining (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Role of GKN1 in gastric cancer (2014, Helicobacter pylori,Homo sapiens)
• Angiopoietin (Ang)/Tie2 pathway and its role in vascular remodeling (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila (2014, NA)
• De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana (2014, Octopus vulgaris,Aggregata octopiana,Homo sapiens)
• De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana (2014, Octopus vulgaris,Aggregata octopiana,Homo sapiens)
• De Novo Transcriptome Sequencing of the Octopus vulgaris Hemocytes Using Illumina RNA-Seq Technology: Response to the Infection by the Gastrointestinal Parasite Aggregata octopiana (2014, Octopus vulgaris,Aggregata octopiana,Homo sapiens)
• The bHLH-PAS Transcription Factor Dysfusion Regulates Tarsal Joint Formation (2014, Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus)
• LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Drosophila melanogaster)
• Inhibition of angiogenic pathways: targeting multiple angiogenic ligands and cell membrane receptors.Notes: Tumor and host endothelial cells release angiogenic ligands that interact in an autocrine and paracrine fashion (2014, NA)
• KEGG pathway for Huntington's disease (proteins identified in our study of the PBMC proteome are highlighted by red stars) (2014, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Identification of molecular pathways that are altered by Atbf1 inactivation in mouse prostates (2014, NA)
• PDLIM2 has an essential function in maintaining breast epithelial cell polarity at the level of feedback signaling through the B1-integrin–FAK–RhoA axis (2014, NA)
• Hippo signaling pathway in stem cell biology and cancer (2014, NA)
• Hippo signaling pathway in stem cell biology and cancer (2014, NA)
• Hippo signaling pathway in stem cell biology and cancer (2014, NA)
• Hippo signaling pathway in stem cell biology and cancer (2014, NA)
• Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease (2014, NA)
• Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease (2014, NA)
• mTOR controls metabolism (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Equus caballus)
• Upstream of mTOR: classical and non-classical inputs (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Equus caballus)
• Mechanism of canonical HH signal transduction in vertebrates (2014, Homo sapiens)
• Studying ultradian oscillations using optogenetic tools (2014, Arabidopsis thaliana,Gallus gallus,Danio rerio,Neurospora crassa,synthetic gene,synthetic construct,Xanthomonas sp.,Erythrobacter litoralis,Homo sapiens,Mus musculus)
• Proposed model for autophagy that implicates PLD (2014, NA)
• Angiogenic–osteogenic coupling mediated by bidirectional cross talk between chondro-/osteoblast lineage cells and skeletal endothelial cells (2014, NA)
• The Therapeutic GADD45B/MKK7-Targeting Strategy in CancerDepicted is the crosstalk between the NFKB and JNK pathways promoting the survival of cancer cells and cells exposed to inflammatory stimuli (2014, NA)
• PRR signaling in testicular cells (2014, NA)
• An IL-1-induced signaling pathway is mediated by K63-linked polyubiquitination of IRF1 (2014, NA)
• The relationship between apoptosis signal regulating kinase 1 (ASK1) and c-Jun N-terminal kinases (JNK)/p38 pathway activated by various stresses (2014, NA)
• Getting ready for building: signaling and autophagosome biogenesis (2014, NA)
• E-cadherin on RTK signalling (2014, NA)
• Signalling pathways connected to autophagy (2014, NA)
• Genotype-specific basis for reprogramming competence (2014, NA)
• Chemokine signaling pathway showing the annotated and non-annotated proteins (2014, NA)
• T cell receptor signaling pathway showing the annotated and non-annotated proteins (2014, NA)
• B cell receptor signaling pathway showing the annotated and non-annotated proteins (2014, NA)
• Toll-like receptor signaling pathway showing the annotated and non-annotated proteins (2014, NA)
• In the hippocampus, the regulation of NMDARs by GAs coupled receptors involves multiple mechanisms (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• GAi coupled receptors increase or decrease NMDAR function depending on the signalling pathways recruited (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway (2014, NA)
• The intracellular mechanism of GnIH and its receptor (GPR147), glutamate and its receptor, dopamine that may control male socio-sexual behavior by regulating the activity of aromatase and neuroestrogen synthesis in the brain (2014, Gallus gallus,Coturnix coturnix,Carassius auratus,Coturnix japonica,Taeniopygia guttata,Sturnus vulgaris,Melospiza melodia,Ficedula hypoleuca,Haplochromis burtoni,Lythrypnus dalli,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Macaca fascicularis,Phodopus sungorus,Phaseolus vulgaris)
• Presents an overview of the Rho/Rho-associated protein kinases signaling pathway (2014, NA)
• Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials (2014, Adeno-associated virus,adeno-associated virus 2,Gekko adenovirus,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Dipturus trachyderma)
• Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights (2014, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Triticum aestivum,Hordeum vulgare,Oryza sativa Japonica Group,Homo sapiens,Mus musculus,Agrobacterium tumefaciens)
• Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer (2014, NA)
• Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway (2014, NA)
• MAP kinase pathway and thyroid carcinoma (2014, NA)
• Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond (2014, NA)
• Numerous proteins that interact with core components of the NOD2 and MAPK signaling pathways were identified as regulators of IL-8 secretion (2014, NA)
• Signaling pathway regulation of autophagy by several factors (2014, NA)
• Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway (2014, NA)
• Pharmacogenomics of insulin-like growth factor-I generation during GH treatment in children with GH deficiency or Turner syndrome (2014, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Cross talk between metformin, androgens, and IGF system and molecular mechanisms of metformin inhibitory effects (2014, NA)
• Controller composed of the KDEL receptor (KDELR) and the Gq and Gs signaling pathways maintains the homeostasis of membrane transport at the Golgi complex (2014, NA)
• Renal cell cancer pathway (2014, NA)
• Hypoxia-inducible factor pathway (2014, NA)
• Pancreatic cancer pathway diagram page (2014, NA)
• RANKL-perturbed network and master regulators (2014, NA)
• mTOR pathway in colorectal cancer: an update (2014, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Citrus macrophylla,Saccharomyces cerevisiae IR-2,Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Moloney murine leukemia virus,Homo sapiens,Streptomyces hygroscopicus)
• mTOR pathway in colorectal cancer: an update (2014, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Citrus macrophylla,Saccharomyces cerevisiae IR-2,Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Moloney murine leukemia virus,Homo sapiens,Streptomyces hygroscopicus)
• Repair of oxidative DNA lesions by the MMR pathway (2014, Escherichia coli,Helicobacter pylori,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Roles of leukotrienes and acetylation in the expression of pro-inflammatory mediators through the NFKB pathway (2014, Mus musculus,Rattus norvegicus,Cavia porcellus,Glycine max,Curcuma longa,Homo sapiens,Elephas maximus)
• The PI3K/Akt/mTOR pathway (2014, Homo sapiens,Mus musculus,Murine leukemia virus,Talaromyces wortmannii)
• Energy regulated signaling pathway (2014, Saccharomyces cerevisiae,Glycine max,Matthiola incana,Curcuma longa,Brassica oleracea,Allium sativum,Encephalitozoon cuniculi,Drosophila melanogaster,Caenorhabditis elegans,Cryptosporidium parvum,Trichomonas vaginalis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Differential Expression of microRNAs in Francisella tularensis-Infected Human Macrophages: miR-155-Dependent Downregulation of MyD88 Inhibits the Inflammatory Response (2014, NA)
• Perspectives of TGFB inhibition in pancreatic and hepatocellular carcinomas (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Citrus macrophylla,NA)
• Signal transduction pathway for type I IFNs and a summary of key ISG effects on the virus and mucosal immune response during influenza (2014, Influenza A virus,unidentified influenza virus,H1N1 subtype,H5N1 subtype,Ebola virus,H3N2 subtype,H7N9 subtype,Influenza A virus H3N2,Bos taurus,Sus scrofa,Ovis aries,Equus caballus,Mustela putorius furo,Nicotiana tabacum,Punica granatum,Homo sapiens,Mus musculus)
• Go in for the kill (2014, NA)
• Signaling pathways involved in YPP regulation (2014, Drosophila melanogaster,Aedes aegypti,Anopheles gambiae,Tribolium castaneum,Culex quinquefasciatus,Blattella germanica,Aedes atropalpus,Culex tarsalis,Homo sapiens,Bos taurus,Gallus gallus)
• Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Metabolic pathway of xylose degradation, glycolysis, and fermentation in Z (2014, Zymomonas mobilis)
• Chemical structure of bilobalide and experimental protocol (2014, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Ginkgo biloba,Homo sapiens)
• piRNA pathways in the Drosophila ovary (2014, NA)
• Proposed model of the mechanisms involved in PAF-mediated EGFR transactivation in SKOV-3 ovarian cancer cells (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Corynephage beta,Moolgarda engeli)
• Apoptotic effects of PEAL on AGS human gastric cancer cells (2014, Allium cepa,Homo sapiens)
• Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells (2014, Armoracia rusticana,Salvia miltiorrhiza,Acalypha australis,Dianthus chinensis,Homo sapiens,Bos taurus)
• Process and mechanisms of blood vessel formation (2014, NA)
• Methamphetamine Alters the Normal Progression by Inducing Cell Cycle Arrest in Astrocytes (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Human immunodeficiency virus 1)
• Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation, pRB Phosphorylation and Upregulation of p16 and p21 (2014, Human papillomavirus type 16,Polyomavirus sp.,Merkel cell polyomavirus,Betapolyomavirus hominis,JC polyomavirus,Human papillomavirus type 8,Trichodysplasia spinulosa-associated polyomavirus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus)
• Metabolic pathway of M (2014, Methylococcus capsulatus,Homo sapiens)
• Innate immunity pathways in mosquitoes (2014, NA)
• Schematic model showing AngII regulation of HSD3B1 in H295R cells (2014, Homo sapiens,Mus musculus)
• Ric8 protein regulates the mating and cAMP signal transduction pathways in C (2014, Cryptococcus neoformans)
• Rho GTPase signaling pathways regulating neuronal survival (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,Drosophila melanogaster,Clostridioides difficile)
• Nuclear A1‐AR signaling in adult cardiac myocytes (2014, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens)
• The putative cross-talk between NFKB, oxidative stress, intracellular Ca2+, and the RAS in cardiac myocytes exposed to hyperglycemia (2014, NA)
• Stimulatory effect of ANG II on ROMK channel activity mediated via AT2Rs (2014, NA)
• Diagram representing the interactions between the sensory nerves, skin, and arterioles (2014, NA)
• Proposed effect of VASP on insulin resistance and inflammatory signaling (2014, Mus musculus,Bos taurus,Homo sapiens)
• MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection (2014, NA)
• Novel pathway links telomeres to NK-cell activity (2014, Homo sapiens,Mus musculus)
• Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance (2014, NA)
• TXNIP deficiency disrupts mitochondrial fuel selection (2014, Mus musculus,Homo sapiens)
• Proposed model for the negative or positive regulation of chondrocyte maturation or apoptosis by Smpd3/nSMase2, respectively (2014, Mus musculus,Homo sapiens)
• Src family kinases in Gq- and Gi-coupled receptor signaling (2014, NA)
• JNK signaling (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• EPA metabolome in the body (2014, NA)
• Trafficking of TLR4 (2014, NA)
• Formal Modelling of Toll like Receptor 4 and JAK/STAT Signalling Pathways: Insight into the Roles of SOCS-1, InterferonB and Proinflammatory Cytokines in Sepsis (2014, NA)
• Role of Heme Oxygenase-1 in Postnatal Differentiation of Stem Cells: A Possible Cross-Talk with MicroRNAs (2014, NA)
• Role of Heme Oxygenase-1 in Postnatal Differentiation of Stem Cells: A Possible Cross-Talk with MicroRNAs (2014, NA)
• Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1 (2014, NA)
• Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFKB Inhibitor (2014, NA)
• Mononuclear Phagocyte System in Homeostasis and Disease: A Role for Heme Oxygenase-1 (2014, NA)
• Addition of RASAL1 to the canonical scheme of the RAS-coupled MAPK and PI3K pathways (2014, NA)
• Involvement of microRNAs (miRNAs) in epithelial-mesenchymal transition (EMT)-related metastasis (2014, NA)
• Metabolic pathway of insulin signalling pathway for unigenes by KEGG annotation (2014, NA)
• Possible mechanism of LRP6 endocytosis and phosphorylation and their relationship to Wnt/Beta-catenin signaling activation (2014, Homo sapiens)
• Molecular pathways altered by green tea extract (2014, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Human papillomavirus,Human papillomavirus type 16,Camellia sinensis,Homo sapiens)
• Role of MicroRNA Modulation in the InterferonA/Ribavirin Suppression of HIV-1 In Vivo (2014, Homo sapiens,Human immunodeficiency virus 1,clinical samples,NA)
• Maternal Obesity and Tobacco Use Modify the Impact of Genetic Variants on the Occurrence of Conotruncal Heart Defects (2014, NA)
• Known Inputs into the Fog Signaling Pathway (2014, NA)
• Fog Signaling Pathway (2014, NA)
• The current understanding of p38D MAPK signalling and activation (2014, NA)
• Cold sensing and responsive pathway in rice (2014, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Lareunionomyces loeiensis,Triticum aestivum,Hordeum vulgare,Matthiola incana,Oryza sativa Japonica Group,Oryza sativa Indica Group,Zizania,Eleusine coracana,Oryza rufipogon,Eleusine coracana subsp. coracana,Olea europaea subsp. cuspidata,Osmunda japonica,Homo sapiens)
• Monte-Carlo Modeling of the Central Carbon Metabolism of Lactococcus lactis: Insights into Metabolic Regulation (2014, NA)
• Genistein suppresses tumor necrosis factor Alpha-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor KB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Glycine max)
• Regulation of TCF7 by hsa-miR-20b-5p and hsa-miR-17-5p in a thyroid cancer pathway (2014, Homo sapiens,Mus musculus,Dipturus trachyderma,actinobacterium 4b-1)
• Regulation of TCF7 and HSP90AA1 by hsa-miR-185-5p in a prostate cancer pathway (2014, Homo sapiens,Mus musculus,Dipturus trachyderma,actinobacterium 4b-1)
• Regulation of YWHAG, YWHAB, and PCNA by hsa-miR-185-5p in a cell cycle pathway (2014, Homo sapiens,Mus musculus,Dipturus trachyderma,actinobacterium 4b-1)
• Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice (2014, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Gallus gallus)
• Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes (2014, Homo sapiens,Sequoia sempervirens)
• Genetic Factors Associated with Spontaneous Preterm Birth and Pre-Labor Preterm Rupture of Membranes (2014, Homo sapiens,Sequoia sempervirens)
• Putative model of Ahnak-dependent activation of TGFB signaling (2014, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mouse mammary tumor virus,Human papillomavirus type 16,Chlorocebus aethiops,Mus musculus,Saccharomyces cerevisiae)
• A model for action of DOX within key signaling pathways necessary for LTF (2014, NA)
• Therapeutic Considerations in Treating HER2-Positive Metastatic Breast Cancer (2014, NA)
• PtdOH biosynthesis and metabolism (2014, Homo sapiens,Saccharomyces cerevisiae)
• Bile acid feedback inhibition of bile acid synthesis (2014, NA)
• HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors (2014, NA)
• Tazarotene Induces Apoptosis in Human Basal Cell Carcinoma via Activation of Caspase-8/t-Bid and the Reactive Oxygen Species-Dependent Mitochondrial Pathway (2014, Homo sapiens)
• Melanoma signaling pathway (2014, Homo sapiens,Mus musculus)
• Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27 (2014, NA)
• Metabostemness: a metabolo-epitranscriptional switcher (2014, Olea europaea,Taraxacum officinale,Homo sapiens,Mus musculus)
• Lcn2 role as a negative regulator in NFKB-STAT3 loop activation in macrophages (2014, NA)
• MicroRNAs expression profile in CCR6+ regulatory T cells (2014, NA)
• Perturbation of ER protein processing pathway at 24 h after MPP+ treatment (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Human immunodeficiency virus)
• Perturbation of MAPK signaling pathway at 24 h after MPP+ treatment (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Human immunodeficiency virus)
• Perturbation of the MAPK signaling pathway at 9 h after MPP+ treatment (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Human immunodeficiency virus)
• The role of the VHL elongin BC complex in the HIF1 pathway in normoxic, hypoxic, and pseudohypoxic conditions (2014, Homo sapiens)
• Model showing that nsp4 suppresses the NFKB signaling pathway by mediating the cleavage of NEMO, leading to the downregulation of IFNB expression (2014, Sus scrofa,Porcine reproductive and respiratory syndrome virus,Homo sapiens)
• Identification of a PKA-independent pathway controlling AQP2 trafficking (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Vascular smooth muscle contraction pathway (2014, NA)
• Cell cycle pathway (2014, NA)
• The relationship between mechanical stress and the expression of PGE2 and related molecules (2014, NA)
• Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response (2014, NA)
• Mathematical Models Light Up Plant Signaling (2014, Arabidopsis thaliana)
• Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo (2014, NA)
• Comparative Transcriptome Analysis Reveals the Genetic Basis of Skin Color Variation in Common Carp (2014, Gallus gallus,Danio rerio,teleost fish,Cyprinus carpio,Oryzias latipes,Ictalurus punctatus,Cyprinus carpio color,Cyprinus carpio haematopterus,Cyprinus carpio koi,Tor douronensis,Cyprinus carpio xingguonensis,Leuciscus waleckii,Bos taurus,Canis lupus familiaris,Sus scrofa,Ovis aries,Equus caballus,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathways and mechanisms underlying the enhancement of endothelial dysfunction in aged mice subjected to sepsis (2014, Homo sapiens,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Mandrillus leucophaeus,Escherichia coli,Oryctolagus cuniculus,Triportheus paranensis,Chenuda virus)
• Helicobacter pylori mediated downregulation of B7-H2 on gastric epithelial cell inhibits Th17 cell development and facilitates bacterial persistence (2014, Helicobacter pylori,Homo sapiens)
• BMP signaling in germ cells across the Metazoa (2014, Mus musculus,Gryllus bimaculatus,Homo sapiens)
• Apoptosis inducers in chronic lymphocytic leukemia (2014, Curcuma longa,Garcinia mangostana,Homo sapiens,Mus musculus)
• Apoptosis inducers in chronic lymphocytic leukemia (2014, Curcuma longa,Garcinia mangostana,Homo sapiens,Mus musculus)
• ER, COX-2 and HER-2/neu interactions (2014, Homo sapiens)
• Intricate pathway of molecular mechanisms involved in the progression of virus-related liver injury to cirrhosis and hepatocellular carcinoma (2014, NA)
• Schematic description of proposed processes in the gill epithelium of Hyas araneus in response intermediate P CO 2exposure (2014, NA)
• The metabolism pathway utilized by DGKD (2014, NA)
• Summary of the mechanism by which BrZ7 participates in 20E and JH pathways (2014, Helicoverpa armigera)
• PI3K/AKT pathway (A) Insulin receptor level processes (2014, Homo sapiens)
• Pathway analysis (2014, NA)
• Molecular signaling altered in Fragile X syndrome (2014, Mus musculus,Rattus norvegicus,Agaricus bisporus,Asplenium fragile,Homo sapiens,Drosophila melanogaster)
• Motif-mediated interactions annotated in the ELM resource mapped onto the KEGG () human Phosphatidylinositol-3′-kinase-(PI3K)–Akt signaling pathway (hsa04151) (2014, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Reactive Oxygen Species Adversely Impacts Bone Marrow Microenvironment in Diabetes (2014, Homo sapiens)
• Proanthocyanidin biosynthetic pathway with transcript levels of each biosynthetic gene estimated by 454 read numbers, and structures of proanthocyanidins and their derivatized products (2014, NA)
• Proposed mechanisms by which miR-34a regulates mesangial cell proliferation (2014, Armoracia rusticana,Diaporthe sclerotioides,Tripterygium wilfordii,Bos taurus,Capra hircus,Homo sapiens,Rattus norvegicus,Caenorhabditis elegans)
• Intracellular TLR signaling and trafficking in pDCs (2014, Escherichia coli,Listeria monocytogenes,Plasmodium falciparum,Toxoplasma gondii,Homo sapiens,Mus musculus,Candida dubliniensis,Vesicular stomatitis virus)
• Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Listeria monocytogenes)
• Proposed novel signaling pathway by which PDE4 regulates BK channel activity in DSM cells (2014, Cavia porcellus,Homo sapiens)
• Regulation of autophagy by ARV (2014, NA)
• ABCA1 expression and function can be induced by GPR119 to protect from atherosclerosis (2014, Mus musculus,Homo sapiens)
• High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells (2014, Dengue virus,West Nile virus,Japanese encephalitis virus,Dengue virus type 2,Dengue virus group,Dengue virus type 3,Bos taurus,Oryctolagus cuniculus,Cervus elaphus,Armoracia rusticana,Oryza sativa,Plasmodium falciparum,Aedes albopictus,Homo sapiens,Mus musculus,Corvus corax,NA)
• Model of Axin autoinhibition (2014, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• Strategies for the production of linear, primary alcohols (2014, Synechocystis sp. PCC 6803,Clostridium acetobutylicum,Mycobacterium marinum,Treponema denticola,Acinetobacter calcoaceticus,Aeromonas caviae,Umbellularia californica,Cuphea hookeriana,Mus musculus,Homo sapiens)
• Expression of genes in the Th1 response network and interferon signaling pathway (2014, NA)
• (Rspo)s in canonical Wnt signaling pathway and the general architecture of (Rspo)s (2014, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Canis lupus familiaris,Xenopus laevis,Mouse mammary tumor virus)
• Downstream genes chosen from KEGG annotated in Wnt/Beta-catenin pathway (2014, NA)
• Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism (2014, NA)
• Estrogen Regulation of microRNAs, Target Genes, and microRNA Expression Associated with Vitellogenesis in the Zebrafish (2014, NA)
• Schematic diagram depicting the most representative signaling of the PI3K/AKT pathway (2014, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Insulin/IGF-1 signaling pathways (2014, Homo sapiens,Mus musculus,Coregonus peled)
• Top networks observed in Ingenuity Pathway Analysis (IPA) (2014, NA)
• Endothelial versus cancer metabolism (2014, NA)
• Anti-neoplastic properties of hydralazine in prostate cancer (2014, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Calloplesiops altivelis)
• Computational gene interaction predictions: network of E12 telencephalon-specific miRNA involved in the Neurotransmitters and other nervous system signalling pathways (2014, NA)
• Regulation of Constitutive Neutrophil Apoptosis Due to House Dust Mite Allergen in Normal and Allergic Rhinitis Subjects (2014, NA)
• Direct and indirect mechanisms for the regulation of gene expression by estrogen (2014, NA)
• Antibodies directed against receptor tyrosine kinases (2014, NA)
• Gene interaction networks specific to the varying doses of 60Co radiation exposure (2014, Homo sapiens,Mus musculus)
• Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/Beta-catenin signalling in pancreatic adenocarcinoma (2014, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Danio rerio,clinical samples)
• Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma (2014, NA)
• IFNAlpha-2b signaling via JAK-STAT pathway, adapted from (2014, Homo sapiens,Escherichia coli IS1,synthetic gene,NA)
• Late signaling events in de novo cytokine/chemokine production (2014, NA)
• New anti-complement drugs: not so far away (2014, Homo sapiens)
• Action for the NO2− in cardiovascular diseases (2014, Homo sapiens,Mus musculus)
• Prolyl-Hydroxylase Inhibitor, Ethyl-3,4-Dihydroxybenzoate, Induces Cell Autophagy and Apoptosis in Esophageal Squamous Cell Carcinoma Cells via Up-Regulation of BNIP3 and N-myc Downstream-Regulated Gene-1 (2014, Armoracia rusticana,Arachis hypogaea,Camellia sinensis,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Hepatitis B virus,Venustaconcha ellipsiformis)
• An Integrated Ontology Resource to Explore and Study Host-Virus Relationships (2014, NA)
• AC in vascular endothelium (2014, Homo sapiens,Embryophyta)
• Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma (2014, NA)
• Paraquat hijacks the PPP to induce oxidative stress and cell death (2014, Mus musculus,Rattus norvegicus,Homo sapiens,Venustaconcha ellipsiformis)
• Human Cardiac Hypertrophic Response pathway from WikiPathways used in the manuscript: http://wikipathways.org/instance/WP2795_r76316 (2014, Homo sapiens)
• Cardiac Hypertrophic Response pathway loaded as a pathway (2014, Homo sapiens)
• Putative model of the mechanism of vascular homeostasis mediated by apelin-APJ signaling (2014, NA)
• Molecular mechanisms of oestrogen action in cardiac cells, such as endothelial cells (2014, NA)
• Role of PDEs in signal termination of PKA-mediated cAMP pathway: The cAMP-PKA signaling pathway can be divided into Activation and Termination phases (2014, Homo sapiens)
• Observed tumor patterns (2014, Homo sapiens,Rattus norvegicus,Diaporthe sclerotioides,clinical samples,NA)
• Emergence and Evolutionary Analysis of the Human DDR Network: Implications in Comparative Genomics and Downstream Analyses (2014, NA)
• Summary of key changes in cancer metabolic reprogramming (2014, NA)
• Summary of the mechanism of several important drug candidates for anti-cancer metabolism therapies (2014, NA)
• Multiple leptin signaling pathways (2014, Mus musculus,Rattus norvegicus,Homo sapiens)
• Illustration of the cellular mechanisms by which BK channels mediate Beta-adrenergic relaxation in UBSM cells with demonstration of the differential outcomes in the wild-type (WT) mouse (top) and the BK-knockout (KO) mouse (bottom), respectively (2014, NA)
• mTOR transcriptional activity (2014, NA)
• Schematic summary highlighting the role of SP and its constituents (PGE2 and EGF) in the regulation of signaling pathway mediating IL-1A (IL-1 alpha) expression in cervical epithelial cells (2014, NA)
• AB production and removal from the brain (2014, Mus musculus,Rattus norvegicus,Panax ginseng,Citrus depressa,Homo sapiens,Drosophila melanogaster,Sus scrofa,Geositta cunicularia)
• T-Plastin Expression Downstream to the Calcineurin/NFAT Pathway Is Involved in Keratinocyte Migration (2014, NA)
• Canonical nuclear factor kappa B (NFKB) signaling (2013, NA)
• Identification of mutated core cancer modules by integrating somatic mutation, copy number variation, and gene expression data (2013, Homo sapiens,Mus musculus)
• Summary of signaling pathway by which PP-fold peptides increase cell proliferation (2013, NA)
• Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2A Expression (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Sequoia sempervirens)
• Induction of gamma-globin gene expression via GPCR signaling and NO-cGMP pathway (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis,Avian sarcoma virus 17)
• mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development (2013, Drosophila melanogaster,Caenorhabditis elegans,Cerobasis alpha,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• Scheme of the andrographolide regulatory pathway (2013, Andrographis paniculata,Homo sapiens)
• MAPK signalling pathway (2013, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Canis lupus familiaris)
• Wnt signalling pathway (2013, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Canis lupus familiaris)
• Intrinsic apoptosis signaling pathway.(A) Schematic diagram of the intrinsic or mitochondria apoptosis signaling pathway (2013, NA)
• Hypothetical pathways involved in MHC–self peptide-TCR recognition and PNH clone dominance (2013, NA)
• Links between Toll-like receptor 4 and breast cancer (2013, NA)
• Links between Toll-like receptor 4 and breast cancer (2013, NA)
• Forging a link between oncogenic signaling and immunosuppression in melanoma (2013, NA)
• Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in ApcMin/+ Mice through Transcriptomic and Metabolomic Reprogramming (2013, NA)
• Functional analysis of the gene expression networks, performed using Ingenuity Pathway Analysis (IPA) (2013, Escherichia coli,Listeria monocytogenes,Streptococcus pneumoniae,Haemophilus influenzae,Neisseria meningitidis,Streptococcus agalactiae,Pannonibacter phragmitetus,Neisseria meningitidis NM23,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus)
• Most significant GeneGO pathway map (2013, NA)
• Oxygen-regulated COX subunit isoform switch in yeast and mammals (2013, NA)
• Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia (2013, NA)
• Phytochemicals targeting NFkB signaling pathway (2013, NA)
• Hepatic genes differentially regulated by 17Beta-trenbolone: Impacts on metabolic pathways (2013, Gambusia holbrooki,Homo sapiens)
• Interaction network of genes differentially expressed in response to glatiramer acetate (GA) (2013, NA)
• Multifunctional phosphorylated PDZ proteins integrate signaling pathways to control hyperplasia, neoplasia, and cell metastasis (2013, NA)
• Schematic illustrating mechanism for expression and function of regulatory genes for development of the oviduct and for development of epithelial-derived ovarian cancer (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Gallus gallus)
• Progesterone functions via intrinsic (mitochondria-centered) and extrinsic (cell membrane-mediated) pathway of apoptosis (2013, NA)
• Pathway where human papillomavirus (HPV)16 E5, E6 and E7 oncoproteins regulate cyclooxygenase-2 (COX-2) expression associated with the cervical carcinogenesis (2013, NA)
• Toll-like receptor signaling pathway in response to MDV infection (2013, Homo sapiens,Gallus gallus,Gallid alphaherpesvirus 2)
• JAK/STAT signaling pathway in response to MDV infection (2013, Homo sapiens,Gallus gallus,Gallid alphaherpesvirus 2)
• Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Dictyostelium discoideum,Escherichia coli O157H7)
• Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Dictyostelium discoideum,Escherichia coli O157H7)
• Digital Gene Expression Tag Profiling Analysis of the Gene Expression Patterns Regulating the Early Stage of Mouse Spermatogenesis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Dictyostelium discoideum,Escherichia coli O157H7)
• Prioritizing Disease Candidate Proteins in Cardiomyopathy-Specific Protein-Protein Interaction Networks Based on “Guilt by Association” Analysis (2013, NA)
• Network related to cell cycle and cell death in islets cultured at 23 mM glucose concentration (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Network related to lipid metabolism in islets cultured at 23 mM glucose concentration (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Pathway analysis identifies a network of genes related to lipid metabolism in islets cultured at 5.6 mM glucose concentration (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Co-expression network of 106 genes associated to the FA metabolism in P (2013, NA)
• Aminoacyl-tRNA synthetases in medicine and disease (2013, NA)
• Example metabolic network involving glycolysis and pentose phosphate pathway (2013, Homo sapiens,Escherichia coli)
• Representation of the top canonical pathway ‘interferon signalling’ detected when simultaneously analysing the mRNA and miRNA data sets with IPA (2013, Caenorhabditis elegans,Venustaconcha ellipsiformis,Homo sapiens,Mus musculus,metagenome)
• Differential Expression Analysis for Pathways (2013, Homo sapiens,Mus musculus)
• Conjunctival MicroRNA Expression in Inflammatory Trachomatous Scarring (2013, Helicobacter pylori,Listeria monocytogenes,Chlamydia trachomatis,Homo sapiens,Mus musculus,clinical samples)
• Interaction of Neisserial surface molecules with the complement system (2013, NA)
• FA and LC-PUFA synthesis in P (2013, NA)
• Pathways leading to actin polymerization in the myogenic response (2013, NA)
• MAPK1 activation is required for cell proliferation in the germinative zone during lens development (2013, Mus musculus,Homo sapiens)
• Systems Modeling of Anti-apoptotic Pathways in Prostate Cancer: Psychological Stress Triggers a Synergism Pattern Switch in Drug Combination Therapy (2013, NA)
• Mechanism of response to anti-EGFR inhibitors (2013, Homo sapiens,Sequoia sempervirens)
• Biochemical adaptations of mammalian hibernation and naturally induced reversible insulin resistance (2013, NA)
• SIRT1 negatively regulates amyloid-beta-induced inflammation via the NFKB pathway (2013, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Homo sapiens,Mus musculus)
• Both G-protein and Beta-arrestin mediated signaling pathways can lead to ERK activation (2013, Homo sapiens,Mus musculus)
• ERK/MEK pathway (2013, Homo sapiens,Sequoia sempervirens)
• Proposed molecular mechanisms of the anti-inflammatory effects of allosteric SHIP1 activation (2013, NA)
• Dexamethasone (Dex) induces the osteogenic differentiation of stem cells by increasing the transcription of FHL-2 (2013, NA)
• IPA pathways of ChIP-Seq-based NSRF target genes in ESC (2013, NA)
• Structural Phylogenomics Reveals Gradual Evolutionary Replacement of Abiotic Chemistries by Protein Enzymes in Purine Metabolism (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Gallus gallus,PX clade,Homo sapiens)
• Cartoon proposes how MDM2 induces Akt phosphorylation as derived from our observation (2013, Homo sapiens,Mus musculus)
• Proposed pathways for the VEGF-induced induction of NO synthesis in endothelial cells and the actions in smooth muscle cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Corynebacterium phage gamma)
• Putative mechanism for protective effects of cilostazol against retinal damage induced by ischemia/reperfusion (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Bikinia letestui,Homo sapiens)
• Foxa2 deletion leading to premature aging and age-onset obesity (2013, NA)
• Chlorophyll Biosynthesis Gene Evolution Indicates Photosystem Gene Duplication, Not Photosystem Merger, at the Origin of Oxygenic Photosynthesis (2013, NA)
• c-jun N-terminal kinase (JNK) pathway in postmitotic migrating neurons (2013, NA)
• This figure schematically shows the tyrosine kinase receptors, such as RET, EGFR, FGFR, MET, KIT, VEGFR, PDGFR, and some of their downstream effectors (2013, NA)
• Biological processes and genes implicated in the Parkinson's disease (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cell type-specific outcomes of KSHV interactions with CD36 and CD147 signaling pathways (2013, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,Human gammaherpesvirus 8,Measles morbillivirus,Homo sapiens,Candida dubliniensis,Plasmodium falciparum,Meleagris gallopavo,NA,NA)
• Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Schematic diagram of the ZFN, TALEN, and CRISPR/Cas9 genome editing tools (2013, Homo sapiens,Mus musculus,Danio rerio,Human immunodeficiency virus 1)
• CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis (2013, NA)
• TGFB processing and uPA-uPAR-dependent activation (2013, NA)
• Using Biological Pathway Data with Paxtools (2013, Homo sapiens)
• Bright Fluorescence Monitoring System Utilizing Zoanthus sp. Green Fluorescent Protein (ZsGreen) for Human G-Protein-Coupled Receptor Signaling in Microbial Yeast Cells (2013, Zoanthus sp.,Homo sapiens)
• TGFB signaling (2013, NA)
• Inactivation of DNA–Dependent Protein Kinase Promotes Heat–Induced Apoptosis Independently of Heat–Shock Protein Induction in Human Cancer Cell Lines (2013, NA)
• Hippo on the move (2013, NA)
• Adipose tissue insulin sensitivity and macrophage recruitment (2013, NA)
• An Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway (2013, NA)
• SCFAs inhibit the cAMP/PKA/CREB signaling pathway to mediate GH and PRL gene transcription in DCAPCs (2013, NA)
• Integration of metabolic control, cell growth and proliferation, and their regulation by phosphoinositides (2013, NA)
• Btk activates antiapoptotic pathways (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Corynebacterium phage gamma,NA)
• The endocrinology of vitamin D (2013, Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis)
• Roles of let-7 in oxLDL induced VSMCs and ECs apoptosis, proliferation, migration and autophagy (2013, Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Cryptosporidium parvum,Homo sapiens)
• Combination of pathway topology and ab initio reconstructed network (2013, Bos taurus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Salmonella enterica subsp. enterica serovar Typhimurium,Corynebacterium phage gamma,Parthenos sylvia)
• Endogenous small RNA pathways involved in host defense and viral pathogenesis in plants and animals (2013, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Dengue virus,Human betaherpesvirus 5,H1N1 subtype,Human gammaherpesvirus 8,Vaccinia virus,H5N1 subtype,Betapolyomavirus macacae,Polyomavirus sp.,Suid alphaherpesvirus 1,Variola virus,Tobacco etch virus,Cucumber mosaic virus,Potato virus X,Betapolyomavirus hominis,JC polyomavirus,Gallid alphaherpesvirus 2,Potato virus Y,Tomato bushy stunt virus,Plum pox virus,Potato spindle tuber viroid,Alphapolyomavirus muris,Bovine leukemia virus,H7N7 subtype,Meleagrid alphaherpesvirus 1,Macacine alphaherpesvirus 1,Macacine gammaherpesvirus 4,Peach latent mosaic viroid,Rice gall dwarf virus,Bandicoot papillomatosis carcinomatosis virus type 1,Cucurbit yellow stunting disorder virus,Escherichia coli,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Solanum tuberosum,Listeria monocytogenes,Nicotiana benthamiana,Cucumis melo,Pseudomonas aeruginosa 18A,Sulfolobus islandicus,Sulfolobus islandicus LAL141,Bacteriophage sp.,Sulfolobus islandicus rod-shaped virus 2,Homo sapiens,Mus musculus,Gallus gallus,Sus scrofa,NA,NA,NA)
• Signal pathway implicated in disk intervertebral disk degeneration (2013, NA)
• Genetic pathway predicted to regulate the interaction between 5-HT synthesis, transport and degradation and the stress response mediated by the HPA axis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli K-12)
• Simplified model of the regulatory interactions between the serotonin and stress response pathways mediated by the HPA axis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli K-12)
• Prolyl-hydroxylase 3: evolving roles for an ancient signaling protein (2013, NA)
• Schematic illustrating how TNF acts via the Wnt pathway leading to the development of the myofibroblast phenotype (2013, NA)
• Cross-talk between sulfur assimilation and ethylene signaling in plants (2013, NA)
• Adipose tissue insulin sensitivity and macrophage recruitment (2013, NA)
• Ghrelin neuroprotective pathways in Parkinson’s disease (2013, NA)
• Transcriptome Profiling Reveals Th17-Like Immune Responses Induced in Zebrafish Bath-Vaccinated with a Live Attenuated Vibrio anguillarum (2013, Vibrio anguillarum,Homo sapiens)
• Summary of AERD associated single nucleotide polymorphisms in the genes of immune response and arachidonate pathway (2013, NA)
• Summary of Tim-3 expression on different innate immune cell populations and its functions (2013, NA)
• Functionally related pathways of aberrantly methylated and differentially expressed genes in immortalized MEFs (2013, NA)
• Dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence (2013, NA)
• GnRHR (A) and Kiss-R (B) signaling (2013, NA)
• Pathways involved in sensing and responding to double-stranded RNA and other pathogen-associated molecular patterns were suppressed by SMD (2013, Mus musculus,Homo sapiens)
• GPI anchor synthesis (2013, NA)
• Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 Cells (2013, NA)
• Environmental and Nutritional Factors That Affect Growth and Metabolism of the Pneumococcal Serotype 2 Strain D39 and Its Nonencapsulated Derivative Strain R6 (2013, Streptococcus pneumoniae,Streptococcus pyogenes,Lactiplantibacillus plantarum,Lactococcus lactis,Haemophilus influenzae,Streptococcus mutans,Streptococcus thermophilus,Lactobacillus delbrueckii subsp. bulgaricus,Lactococcus lactis subsp. lactis,Streptococcus pneumoniae D39,Mycoplasmoides pneumoniae PO1,Streptococcus pneumoniae R6,Streptococcus mutans S1B,Lactococcus cremoris subsp. cremoris MG1363,Streptococcus pneumoniae 23F,Saccharomyces cerevisiae,Armoracia rusticana,Diaporthe sclerotioides,Matthiola incana,Homo sapiens,Cofana spectra)
• RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in Caenorhabditis elegans (2013, NA)
• Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression (2013, NA)
• PPAR signaling pathway from KEGG (2013, NA)
• PI3K/Akt/mTOR pathway and relative inhibitors in NHL (2013, Homo sapiens,Mus musculus)
• The proposed mechanism by which PGE2signaling amplifies COX-2 expression through an autocrine manner in LPS-stimulated macrophages (2013, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• Cl− channels and proposed functions in vascular smooth muscle cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Xenopus laevis,Vasconcellea candicans)
• Schematic overview of the impact of HDACi on DSB signalling, HR and NHEJ DNA repair pathways (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Proposed schematic representation of Wnt5a/Beta-catenin signaling in keloid pathogenesis (2013, NA)
• Proposed mechanism for the protective effects of carvacrol against hepatic steatosis in mice (2013, Zea mays,Candida dubliniensis,Thymus vulgaris,Satureja thymbra,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• AGE/RAGE signaling pathway in NetSlim- This map represents the NetSlim reactions of AGE/RAGE signaling pathway in different cell types (2013, NA)
• Schematic diagram demonstrating speculated roles of ER stress signaling pathways in diabetic cardiomyopathy. Firstly, under pathological condition of hyperglycemia in myocytes, ROS is generated by glucose oxidation in mitochondria (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Lycium barbarum,NA)
• Major TLR signaling pathways (2013, Homo sapiens)
• Alpha-TEA as a stimulator of tumor autophagy and enhancer of antigen cross-presentation (2013, Mus musculus,Homo sapiens)
• Role of cell cycle regulators in the cellular dormancy (“intrinsic dormancy”) mechanism (2013, Homo sapiens,Mus musculus)
• Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations (2013, Homo sapiens,Mus musculus,Meleagris gallopavo)
• Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations (2013, Homo sapiens,Mus musculus,Meleagris gallopavo)
• Identification of Pathway Markers in Intracranial Aneurysm Using Genome-Wide Association Data from Two Different Populations (2013, Homo sapiens,Mus musculus,Meleagris gallopavo)
• Ingenuity pathway analysis of differences between LPS and LPS + SMD (300mg/kg) with regard to reproductive hormones (2013, Mus musculus,Homo sapiens)
• Time Courses of Changes in Phospho- and Total- MAP Kinases in the Cochlea after Intense Noise Exposure (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Differential Expression of miR-145 in Children with Kawasaki Disease (2013, NA)
• KEGG pathway map for genes in the three modules (2013, Homo sapiens)
• Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3B Signaling and Inhibition of the Mitochondria-Dependent Apoptotic Pathway (2013, Armoracia rusticana,herbal medicine,Panax ginseng,Panax notoginseng,Ganoderma atrum,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Opsanus beta)
• Beauvericin Ameliorates Experimental Colitis by Inhibiting Activated T Cells via Downregulation of the PI3K/Akt Signaling Pathway (2013, Diaporthe sclerotioides,Fusarium oxysporum,Fusarium proliferatum,Fusarium incarnatum,Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus)
• Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK (2013, NA)
• High expression of the ppGalNAc-T13 gene enhances cancer metastasis by formation of trimeric Tn antigen (2013, NA)
• Targeting of the hepatocyte growth factor (HGF)/MET pathway (2013, NA)
• The epidermal growth factor receptor (EGFR) signaling pathway and molecules that may affect drug resistance (2013, Homo sapiens)
• Signaling pathways used by EGF to stimulate goblet cell proliferation (2013, Homo sapiens,Rattus norvegicus)
• Regulatory mechanisms for the Hippo pathway (2013, Drosophila melanogaster,Homo sapiens)
• Sequestration-induced loss of protein C receptors links coagulation, inflammation, and endothelial permeability (2013, NA)
• Generation of a biological network of genes related to the upstream regulator IRF2 (2013, NA)
• Hh pathway response in vertebrates (2013, Homo sapiens)
• MiR-183/Taok1 Target Pair Is Implicated in Cochlear Responses to Acoustic Trauma (2013, NA)
• Effect of Oxygen on Glucose Metabolism: Utilization of Lactate in Staphylococcus Aureus as Revealed by In Vivo NMR Studies (2013, NA)
• ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway (2013, NA)
• Networks wherein various signaling pathways epigenetically affected by MXC exposure intersect and the relationships between affected molecules (2013, NA)
• Transcriptomics of Glucocorticoid Receptor Signaling in Developing Zebrafish (2013, Danio rerio,Salmo trutta,Zootoca vivipara,Lareunionomyces loeiensis,Sequoia sempervirens,Homo sapiens,Mus musculus,Moloney murine leukemia virus,Plasmid pTF1)
• Synaptic activity and energy homeostasis (2013, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Drosophila melanogaster)
• SREBP activation and input from mTORC1 signalling (2013, Homo sapiens)
• Pathways of PI5P synthesis and turnover (2013, NA)
• Role of miR-17 Family in the Negative Feedback Loop of Bone Morphogenetic Protein Signaling in Neuron (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Gene regulatory networks for cDC and pDC development (2013, NA)
• T-cell immune regulation by IDO1 (2013, Encephalomyocarditis virus,Murine leukemia virus,Replication defective viruses,Chlamydia trachomatis,Chlamydia psittaci,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Candida albicans,Leishmania major,NA)
• Signaling downstream IL-2/IL-15RB (2013, Helicobacter pylori,Human alphaherpesvirus 1,Listeria monocytogenes,Matthiola incana,Cryptococcus neoformans,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Panthera tigris,Leishmania infantum)
• Different vesicle transport pathways and the functions of Rab GTPases identified from the hUCBMSC MVs (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Diaporthe sclerotioides)
• Oxidative pathways of alcohol metabolism (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Mosquito innate immune pathways (2013, NA)
• Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells (2013, Helicobacter pylori)
• Schematic drawing of the PI3K/Akt signaling pathway (2013, NA)
• As a key regulator of cellular survival the PI3K/Akt signaling pathway is often triggered by viruses (2013, NA)
• Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion (2013, NA)
• Transcriptional changes in the WNT signaling pathway of E11.5 Sost–/–; Sostdc1–/– limbs (2013, NA)
• Comparison of gene expression changes in human bladder cancer and our mouse model based on KEGG pathway analysis (2013, NA)
• Regulatory networks of mTOR inhibitors and miRNAs in controlling the mTOR pathway in cancer (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Streptomyces hygroscopicus)
• mTOR signalling pathway (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Streptomyces hygroscopicus)
• Mechanism of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) (2013, Homo sapiens,Mus musculus,Nicotiana tabacum,NA)
• Working model for rotavirus cell entry (2013, Homo sapiens,Chlorocebus aethiops)
• Ingenuity Pathway analysis of lung cancer and/or COPD versus controls revealed NFKB as a major foundation (2013, NA)
• Regulation of PGC-1A—this schematic represents the relationship between nutrition, circadian clock and other regulatory factors involved in post-translational modification of PGC-1A and its consequent impact on metabolic genes and aging (2013, Drosophila melanogaster,Caenorhabditis elegans,Pyrrhocoris apterus,Acheta domesticus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Vipera berus)
• PI3K/Akt-mediated mTOR activation positively regulates protein synthesis (2013, NA)
• Time schedule of viral-induced interference with PI3K/Akt signaling based on the time point of activation and benefit during viral life cycles (2013, NA)
• p53/p21/pRb/E2F and p16/pRb/E2F signaling pathway (2013, NA)
• Chromatin-remodeling factors affect the cell cycle (2013, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Hepatitis B virus,Dipturus trachyderma)
• P53 signaling pathway interacts with chromatin-remodeling factors in response to DNA damage (2013, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Hepatitis B virus,Dipturus trachyderma)
• Interaction of marine compounds on survival and apoptotic signaling molecules (2013, Haliclona sp.,Zyzzya fuliginosa,Hyrtios erectus,Dicathais orbita,Cystodytes dellechiajei,Streptomyces sp.,Salinispora arenicola,Streptomyces sp. 04,PX clade,Ecklonia cava,Homo sapiens,Mus musculus,Bos taurus,uncultured actinomycete,NA)
• Genes in the insulin signaling KEGG pathway that are directly or indirectly regulated by EBF1 (2013, Mus musculus,Homo sapiens)
• Pathway of apoptosis (2013, Haliclona sp.,Zyzzya fuliginosa,Hyrtios erectus,Dicathais orbita,Cystodytes dellechiajei,Streptomyces sp.,Salinispora arenicola,Streptomyces sp. 04,PX clade,Ecklonia cava,Homo sapiens,Mus musculus,Bos taurus,uncultured actinomycete,NA)
• Scheme of survival signaling cascade by receptor tyrosine kinases via PI3K/AKT mediated survival (2013, Haliclona sp.,Zyzzya fuliginosa,Hyrtios erectus,Dicathais orbita,Cystodytes dellechiajei,Streptomyces sp.,Salinispora arenicola,Streptomyces sp. 04,PX clade,Ecklonia cava,Homo sapiens,Mus musculus,Bos taurus,uncultured actinomycete,NA)
• Scheme of PI3K/AKT mediated antiapoptotic regulations at the mitochondria (2013, Haliclona sp.,Zyzzya fuliginosa,Hyrtios erectus,Dicathais orbita,Cystodytes dellechiajei,Streptomyces sp.,Salinispora arenicola,Streptomyces sp. 04,PX clade,Ecklonia cava,Homo sapiens,Mus musculus,Bos taurus,uncultured actinomycete,NA)
• An immune synapse and downstream events (2013, NA)
• Signaling pathway that regulates basal P-glycoprotein activity in brain capillaries (2013, NA)
• Hepatic cholesterol synthesis and catabolism enzymes, uptake receptors, BA transport systems, phase II detoxification enzymes, and nuclear receptors investigated in this study (2013, NA)
• Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Xenopus laevis,vectors)
• Simplified scheme of cdB3-based control of glucose metabolism in RBCs (2013, NA)
• Role of CTLA4 in the Proliferation and Survival of Chronic Lymphocytic Leukemia (2013, NA)
• Schematic diagrams of WWOX structure and its role in signaling (2013, NA)
• Schematic illustrating the cancer utilization of the metabolic pathways (2013, NA)
• Transient receptor potential vallinoid 1 (TRPV1) in early-phase response in allergic rhinitis (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Role of epidermal growth factor receptor in acute and chronic kidney injury (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed Adipose Stromal Cell-derived IL-6 signaling pathway (2013, NA)
• Gene Network Analysis of Candidate Loci for Human Anorectal Malformations (2013, Homo sapiens,Mus musculus)
• DNA damage signaling at replication forks (2013, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Gene Expression Profile Analysis of Type 2 Diabetic Mouse Liver (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• An RNAi-Based Dimorphic Genetic Screen Identified the Double Bromodomain Protein BET-1 as a Sumo-Dependent Attenuator of RAS-Mediated Signalling (2013, NA)
• p110D PI3K mediates the effects of CSF-1 or EGF via RhoA and PTEN in macrophages and some solid tumor cells (2013, NA)
• p110D PI3K pathway in B cells (2013, NA)
• Simplified scheme showing the critical role of Class IA PI3Ks in multiple cellular functions (2013, NA)
• Simplified scheme showing the differential activation of class IA and class IB PI3K isoforms (2013, NA)
• Involvement of YAP in the DNA damage response (2013, NA)
• The Drosophila Hippo pathway (2013, NA)
• Net Expression Inhibits the Growth of Pancreatic Ductal Adenocarcinoma Cell PL45 In Vitro and In Vivo (2013, NA)
• Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network (2013, Escherichia coli,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica,Vibrio cholerae,Salmonella enterica subsp. enterica serovar Typhi,Corynebacterium diphtheriae,Pyrococcus horikoshii,Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Kluyveromyces lactis,Saccharomyces cerevisiae BY4741,Sordaria araneosa,vectors,unidentified shuttle vector,Shuttle vector pSU7,Mus musculus,Cricetulus griseus,Homo sapiens)
• Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci (2013, Solanum tuberosum,Hordeum vulgare,Aspergillus fumigatus,Sorghum bicolor,Aspergillus nidulans,Neurospora crassa,Fusarium graminearum,Ustilago maydis,Pyricularia grisea,Lolium perenne,Lolium arundinaceum,Cynodon dactylon,Metarhizium anisopliae,Ipomoea purpurea,Blumeria graminis,fungal endophyte,Plenodomus lingam,Fusarium graminearum PH-1,Claviceps purpurea,Epichloe festucae,Pyrenophora tritici-repentis,Metarhizium acridum,Penicillium paxilli,Metarhizium sp. RMK-2011b,Festuca pratensis,Epichloe coenophiala,Epichloe festucae var. lolii,Periglandula ipomoeae,Claviceps cynodontis,Epichloe uncinata,Epichloe typhina,Ipomoea asarifolia,Claviceps fusiformis PRL 1980,Epichloe brachyelytri E4804,Epichloe amarillans E57,Periglandula ipomoeae IasaF13,Claviceps purpurea 20.1,Paspalum dilatatum,Claviceps paspali,Claviceps fusiformis,Aciculosporium take,Epichloe amarillans,Epichloe festucae E2368,Epichloe brachyelytri,Claviceps paspali RRC 1481,Epichloe festucae Fl1,Epichloe glyceriae E277,Aciculosporium take MAFF-241224,Epichloe gansuensis E7080,Epichloe typhina E5819,Epichloe elymi E56,Epichloe typhina E8,Epichloe gansuensis var. inebrians E818,Verticillium epiphytum,Festuca subverticillata,Epichloe gansuensis,Epichloe elymi,Epichloe glyceriae,Claviceps africana,Escherichia coli,Drosophila melanogaster,Escherichia coli str. K-12 substr. DH10B,Pratylenchus scribneri,Homo sapiens,Oryctolagus cuniculus,vectors,Glyptocephalus cynoglossus,NA,NA)
• Plant-Symbiotic Fungi as Chemical Engineers: Multi-Genome Analysis of the Clavicipitaceae Reveals Dynamics of Alkaloid Loci (2013, Solanum tuberosum,Hordeum vulgare,Aspergillus fumigatus,Sorghum bicolor,Aspergillus nidulans,Neurospora crassa,Fusarium graminearum,Ustilago maydis,Pyricularia grisea,Lolium perenne,Lolium arundinaceum,Cynodon dactylon,Metarhizium anisopliae,Ipomoea purpurea,Blumeria graminis,fungal endophyte,Plenodomus lingam,Fusarium graminearum PH-1,Claviceps purpurea,Epichloe festucae,Pyrenophora tritici-repentis,Metarhizium acridum,Penicillium paxilli,Metarhizium sp. RMK-2011b,Festuca pratensis,Epichloe coenophiala,Epichloe festucae var. lolii,Periglandula ipomoeae,Claviceps cynodontis,Epichloe uncinata,Epichloe typhina,Ipomoea asarifolia,Claviceps fusiformis PRL 1980,Epichloe brachyelytri E4804,Epichloe amarillans E57,Periglandula ipomoeae IasaF13,Claviceps purpurea 20.1,Paspalum dilatatum,Claviceps paspali,Claviceps fusiformis,Aciculosporium take,Epichloe amarillans,Epichloe festucae E2368,Epichloe brachyelytri,Claviceps paspali RRC 1481,Epichloe festucae Fl1,Epichloe glyceriae E277,Aciculosporium take MAFF-241224,Epichloe gansuensis E7080,Epichloe typhina E5819,Epichloe elymi E56,Epichloe typhina E8,Epichloe gansuensis var. inebrians E818,Verticillium epiphytum,Festuca subverticillata,Epichloe gansuensis,Epichloe elymi,Epichloe glyceriae,Claviceps africana,Escherichia coli,Drosophila melanogaster,Escherichia coli str. K-12 substr. DH10B,Pratylenchus scribneri,Homo sapiens,Oryctolagus cuniculus,vectors,Glyptocephalus cynoglossus,NA,NA)
• Antiviral and immune regulated function of IFIT family genes (2013, Hepatitis B virus,Influenza A virus,Human papillomavirus,Vesicular stomatitis virus,West Nile virus,Betapolyomavirus macacae,Japanese encephalitis virus,Human alphaherpesvirus 3,Porcine reproductive and respiratory syndrome virus,ssRNA viruses,dsRNA viruses,Murine adenovirus 1,Human adenovirus 12,Homo sapiens,Macaca mulatta,Callithrix jacchus,Hylobates sp.,marmosets,Pongo abelii,Nomascus leucogenys,Bos taurus,Canis lupus familiaris,Sus scrofa,Equus caballus,Monodelphis domestica,Gallus gallus,Danio rerio,Xenopus tropicalis,Gastrotheca marsupiata,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Neisseria meningitidis,Chlamydia pneumoniae,Saccharomyces cerevisiae,NA,NA,NA,NA,NA)
• Signaling pathway of IFIT family genes (2013, Hepatitis B virus,Influenza A virus,Human papillomavirus,Vesicular stomatitis virus,West Nile virus,Betapolyomavirus macacae,Japanese encephalitis virus,Human alphaherpesvirus 3,Porcine reproductive and respiratory syndrome virus,ssRNA viruses,dsRNA viruses,Murine adenovirus 1,Human adenovirus 12,Homo sapiens,Macaca mulatta,Callithrix jacchus,Hylobates sp.,marmosets,Pongo abelii,Nomascus leucogenys,Bos taurus,Canis lupus familiaris,Sus scrofa,Equus caballus,Monodelphis domestica,Gallus gallus,Danio rerio,Xenopus tropicalis,Gastrotheca marsupiata,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Neisseria meningitidis,Chlamydia pneumoniae,Saccharomyces cerevisiae,NA,NA,NA,NA,NA)
• The multiple functions of PE (2013, Haemophilus influenzae)
• Sirt3 deacetylation targets, and regulation of Sirt3 expression and activity (2013, NA)
• Toll-like receptor (TLR) signaling pathway (2013, NA)
• The canonical Hedgehog signalling pathway in mammals (2013, NA)
• Proposed model for TLS pathway (2013, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• TLS synthesis in ICL repair by Fanconi anemia (FA) pathway: replicative DNA polymerase stalls upon encounter of an interstrand crosslink (ICL) in DNA (2013, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Metabolic enzymes with SSB sites were identified within the biosynthetic pathways for methionine, Cys, chorismate, thiamine, GMP, and queuosine (2013, NA)
• Illustration of a signaling pathway involved in histone PTMs in HD (2013, NA)
• cAMP signaling pathway.Notes: Adenylate cyclase, which is a key enzyme located in the cell membrane, generates cAMP (2013, Homo sapiens,Mus musculus,Bos taurus)
• PTEN Increases Autophagy and Inhibits the Ubiquitin-Proteasome Pathway in Glioma Cells Independently of its Lipid Phosphatase Activity (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Obesity Pharmacotherapy: Current Perspectives and Future Directions (2013, NA)
• ADP Protects Cardiac Mitochondria under Severe Oxidative Stress (2013, NA)
• RACK1 signaling complexes (2013, NA)
• Downstream targets of p38 MAPK (2013, NA)
• Putative CA-mediated inhibitory pathway of inflammatory signaling events (2013, NA)
• Schematic signaling pathway of EGCG on PMA-induced MUC5B expression (2013, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma (2013, Prevotella melaninogenica,Haemophilus parainfluenzae,Homo sapiens)
• Predicted membrane structure and proton motive force mechanisms from the three reconstructed Chloroflexi genomes (2013, Pyrococcus furiosus,phototrophic bacterium,Chloroflexus aurantiacus,Herpetosiphon aurantiacus,Sulfurisphaera tokodaii str. 7,Dehalococcoides mccartyi,Dehalococcoides mccartyi CBDB1,Cupriavidus metallidurans CH34,Pelobacter acidigallici,Thermomicrobium roseum,Anaerolinea thermophila,Caldilinea aerophila,Syntrophotalea acetylenica,Ktedonobacter racemifer,Thermobaculum terrenum ATCC BAA-798,Dehalogenimonas lykanthroporepellens,Dehalogenimonas lykanthroporepellens BL-DC-9,Desulfobacula toluolica Tol2,Desulfitobacterium sp. PCE1,Thermobaculum terrenum,Sphaerobacter thermophilus,Anaerolinea thermolimosa,Leptolinea tardivitalis,Levilinea saccharolytica,Thermosporothrix hazakensis,Anaerolinea thermophila UNI-1,metagenome,human metagenome,metagenomes,environmental samples,uncultured bacterium,uncultured Anaerolinea sp.,Homo sapiens,Mustela lutreola)
• Challenging macrophages with PAMPs such as LPS stimulates synthesis of pro-IL-1B and pro-IL-18 (2013, NA)
• EBV-mediated oncogenic signaling pathway activation in EBV-positive diffuse large B-cell lymphoma of the elderly (2013, NA)
• Therapeutic modulation of EBV infection and associated signaling pathways (2013, NA)
• Mechanism of blockade of the Wnt signalling pathway by osteocytes (2013, NA)
• Therapeutically targeting the AMP-activated protein kinase (AMPK) and mammalian target of rapamycin complex (mTORC1) signaling pathways in liver kinase B1 (LKB1) -/- tumors (2013, NA)
• Cited1 Deficiency Suppresses Intestinal Tumorigenesis (2013, NA)
• Activation of different death receptor signaling pathways depending on the culture conditions of hepatocytes (2013, NA)
• Example of differences in use between glycolysis and the ED pathway by representative cells in our modeled population (2013, NA)
• Hypothetical schematic implication of some of the PPAR regulatory network (2013, NA)
• Metabolic adaptations of cancer cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• This diagram summarizes the signaling pathway in thyroid carcinomas (2013, Diaporthe sclerotioides,Terminalia catappa,Homo sapiens)
• Representation of the proposed cellular pathways involved in the acetylcholine (ACh)-induced proliferation of human tendon cells (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Citrus macrophylla,Homo sapiens,Merluccius merluccius)
• PHD2 regulates arteriogenic macrophages through TIE2 signalling (2013, Homo sapiens,Mus musculus,Danio rerio)
• Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium (2013, NA)
• Therapeutic targets of the Wnt signaling pathway (2013, NA)
• Diagrammatic representation of the canonical Wnt signaling pathway (2013, NA)
• CluePedia analysis example using expression data from human normal colon mucosa and colorectal tumors and in silico information (2013, Homo sapiens,Mus musculus,Acanthamoeba polyphaga mimivirus)
• Insulin resistance in the vasculature (2013, NA)
• Using PainNetworks to reproduce the NGF-TrkA signalling pathway (2013, NA)
• Using PainNetworks to reproduce the NRG1-ErbB signalling pathway (2013, NA)
• Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis (2013, NA)
• The intracellular signaling pathways modulated by somatostatin receptors (2013, NA)
• DAMP signaling through different PRRs (2013, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Candida dubliniensis,Talaromyces marneffei,Homo sapiens)
• Metformin and Cancer (2013, Homo sapiens,Mus musculus)
• Apoptotic pathways induced in beta cells in type 2 diabetes (2013, NA)
• Proteasome-dependent degradation of replisome components regulates faithful DNA replication (2013, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Production of reactive oxygen species by the Duox pathway (2013, NA)
• Cell-to-cell signaling network generated by ingenuity pathway analysis of differentially expressed genes: Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line) (2013, NA)
• Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells (2013, Homo sapiens,Macaca mulatta,Mus musculus,Bos taurus)
• Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor (2013, NA)
• Bridging HIV-1 Cellular Latency and Clinical Long-Term Non-Progressor: An Interactomic View (2013, NA)
• Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis (2013, NA)
• Coupling and S1P signaling in mesenchymal cells (2013, NA)
• Apoptosis by hypothermia (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Homo sapiens,Sus scrofa)
• Synthesis of DNA precursors in the cytosol and mitochondria (2013, NA)
• TNFA on regulation of inflammation, immue response, migration, and differentiation (2013, NA)
• Diagram shows the existence of positive feedback between the Wnt and GLP-1/cAMP signaling pathways in the brainstem and hypothalamus (2013, Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Betapolyomavirus macacae,Homo sapiens)
• Transcription at damaged DNA (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Simplified scheme comparing the mechanism of replication of conditionally replicative ONYX in normal cells and neoplastic cells (2013, NA)
• Relationship between binding of ligands to the pattern recognition advance glycation end‐product receptor (RAGE), and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro‐ and microvasculature (2013, Homo sapiens,Mus musculus,Canis lupus familiaris)
• CXCR4 negatively regulates keratinocyte proliferation in IL-23-mediated psoriasiform dermatitis (2013, NA)
• NE input on activity of ventral midbrain DA neurons (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Cancer cells express proton-sensing GPCRs such as GPR4, TDAG8, and OGR1 to regulate their tumorigenesis and invasion (2013, NA)
• Phosphorylation signaling pathway of alternative splicing regulated by mechanical stress (2013, NA)
• Global Assessment of Antrodia cinnamomea-Induced MicroRNA Alterations in Hepatocarcinoma Cells (2013, Matthiola incana,Cinnamomum camphora,Pentacalia desiderabilis,Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Aeromicrobium sp. E12,NA)
• Regulation network of CYP3A4 phenotype expression adapted from Klein et al (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Piromyces finnis)
• Retinal degeneration in animal models with a defective visual cycle (2013, NA)
• Phospholipase D in Modulating the MTOR Signaling Pathway in Polycystic Kidney Disease (2013, Oryctolagus cuniculus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• The Smad-dependent TGFB signalling pathway upon stimulation with TGFB and BMP (2013, Homo sapiens,Mus musculus,Bos taurus)
• Reconstruction and Validation of a Genome-Scale Metabolic Model for the Filamentous Fungus Neurospora crassa Using FARM (2013, Neurospora crassa,Homo sapiens)
• BTK signaling pathway (2013, NA)
• HDTs within the macrophage (2013, NA)
• Polymorphisms of CYP51A1 from Cholesterol Synthesis: Associations with Birth Weight and Maternal Lipid Levels and Impact on CYP51 Protein Structure (2013, Homo sapiens,Mus musculus)
• Schematic diagram proposing the mechanism of cGMP (generated by sGC) mediated neurite extension via inhibition of the Rho signaling pathway in MGE neurons (2013, NA)
• Revisiting MPF activation (2013, NA)
• Breast Cancer Stem Cells: We’ve got them surrounded (2013, Homo sapiens,Mus musculus)
• Differentially Expressed miRNAs after GnRH Treatment and Their Potential Roles in FSH Regulation in Porcine Anterior Pituitary Cell (2013, Bos taurus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Carassius auratus,synthetic RNA)
• Distinct Genomic Aberrations between Low-Grade and High-Grade Gliomas of Chinese Patients (2013, NA)
• Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy (2013, NA)
• Schematic diagram summarizing the key findings (2013, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Glucose deprivation in cancer cells activates UPR following HBP flux reduction (2013, NA)
• Mechanisms underlying anti-angiogenic therapy cardiotoxicity (2013, Homo sapiens)
• Mechanisms underlying modulation of HER2-directed therapy cardiotoxicity through aerobic exercise (2013, Homo sapiens)
• Pre-Symptomatic Activation of Antioxidant Responses and Alterations in Glucose and Pyruvate Metabolism in Niemann-Pick Type C1-Deficient Murine Brain (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Gallus gallus,Danio rerio,Armoracia rusticana,Homo sapiens,NA)
• Mechanisms underlying HER2-directed therapy cardiotoxicity (2013, Homo sapiens)
• HDACi and DNMTi target the MM cell (2013, NA)
• Conserved Wnt pathway branches and components (2013, NA)
• Initiation of endoreplication in Drosophila follicle cells (2013, NA)
• The nuclear pore complex (NPC) and classical nuclear import pathway (2013, NA)
• This figure depicts a model of the lipid synthesis genes in the human mammary epithelial cell during secretory activation according to cell compartment (2013, NA)
• Regulation of the Hippo pathway by cAMP-PKA signaling (2013, Mus musculus,Drosophila melanogaster,Homo sapiens)
• Genetic determination of testes in Japanese medaka fish, chicken, and mouse (2013, NA)
• TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Gallus gallus,Human gammaherpesvirus 4,unidentified shuttle vector)
• Classical and non-classical pathways of androgen biosynthesis (2013, NA)
• Mitogen-activated protein kinase (MAPK) signaling cascade (2013, NA)
• Regulation of action cytoskeleton in LTLT-Ca MCF-7 cells (2013, NA)
• Selected pathways from enriched injured (EI) versus non-enriched (i.e., STD housed) injured (NI): demonstrating calcium signaling importance (2013, NA)
• Simplified overview of inflammation-orchestrated signal transduction that induces pro-tumourigenic responses in glioblastoma (2013, NA)
• HIFs are involved in crucial aspects of tumor progression and metastasis in sarcomas (2013, NA)
• The regulatory role of IRAK-M in TLR-IL-1R signalling (2013, NA)
• Postulated interaction between the insulin signaling pathway and activation of the pro-inflammatory cascade in the pathogenesis of insulin resistance in sepsis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Felis catus)
• Calcineurin-NFAT pathway as an integrator of multiple signaling pathways in the pathogenesis of pulmonary hypertension (PH) (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans)
• The role of PKCθ in TCR activation (2013, NA)
• Pro- and antiapoptotic Ras and Rheb signaling based on different effectors and cellular context (2013, Drosophila melanogaster,Caenorhabditis elegans,Cerobasis alpha,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• A new Vitreoscilla filiformis extract grown on spa water-enriched medium activates endogenous cutaneous antioxidant and antimicrobial defenses through a potential Toll-like receptor 2/protein kinase C, zeta transduction pathway (2013, Vitreoscilla filiformis,Homo sapiens)
• Global Analysis of the Human Pathophenotypic Similarity Gene Network Merges Disease Module Components (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells (2013, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Bos taurus,Armoracia rusticana,Capra hircus,Diaporthe sclerotioides,Equus caballus,Cinchona pubescens,Human immunodeficiency virus,Mouse mammary tumor virus,Homo sapiens)
• Scheme of CML hematopoietic stem cell signaling pathways in which predicted targets of microRNAs associated with CML are involved (2013, NA)
• Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice (2013, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Targeting ubiquitin-dependent degradation of CDK inhibitors (2013, NA)
• G1 cell cycle control by the pRB pathway (2013, NA)
• Glycogen and Glucose Metabolism Are Essential for Early Embryonic Development of the Red Flour Beetle Tribolium castaneum (2013, NA)
• Phosphoinositide signaling and its regulation by phosphatases (2013, NA)
• Regulation of prophase arrest and resumption of meiosis (2013, NA)
• Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice (2013, Homo sapiens,Mus musculus)
• Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance (2013, NA)
• Regulation of proteins translation in Jurkat cells (2013, NA)
• Biochemical pathways leading to resistance to small-molecule epidermal growth factor receptor (EGFR)-targeting drugs such as gefitinib and erlotinib in non-small-cell lung cancer (NSCLC) (2013, Homo sapiens,NA)
• Scheme of the biochemical pathways leading to carotenoids and other terpenoids (2013, NA)
• Hypothetic molecular mechanisms by which adaptogens activate adaptive stress response pathways (2013, NA)
• High-Throughput 3D Screening Reveals Differences in Drug Sensitivities between Culture Models of JIMT1 Breast Cancer Cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Autophagy-related common pathway in neurodevelopmental disorders (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• Nrf2-Keap1 signaling pathway (2013, Homo sapiens,Mus musculus)
• Methylated DNA Binding Domain Protein 2 (MBD2) Coordinately Silences Gene Expression through Activation of the MicroRNA hsa-mir-496 Promoter in Breast Cancer Cell Line (2013, Mus musculus,Bos taurus,Ovis aries,Cricetulus griseus,Homo sapiens,Human T-cell leukemia virus type I)
• Acetic acid stress response in S (2013, NA)
• Effect of ethanol treatment on the AMPK-related lipid metabolism pathway (2013, NA)
• Transmembrane protein UNC93B1 (black spring-like shape) associates with various toll-like receptors (horseshoe-like shapes) in the endoplasmic reticulum to help load them into vesicles coated with COPII for transport to the Golgi (2013, NA)
• Flowering time genes recently identified as targets of selection in crop species (2013, NA)
• TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans (2013, Caenorhabditis elegans,Homo sapiens)
• Ingenuity pathway analysis of the top-ranked network (2013, NA)
• TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans (2013, Caenorhabditis elegans,Homo sapiens)
• Folate metabolic pathway (2013, Homo sapiens)
• Mitochondrial biogenesis by HLA20 involves activation of the Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1 Alpha (PGC-1A) pathway (2013, NA)
• Molecules examined by immunohistochemistry (2013, NA)
• TARGETING THE eIF4A RNA HELICASE BLOCKS TRANSLATION OF THE MUC1-C ONCOPROTEIN (2013, Mus musculus,Rattus norvegicus,Armoracia rusticana,Aglaia silvestris,Homo sapiens,Bos taurus)
• Connective tissue growth factor (CTGF) stimulates the TGFBeta-Smad signalling pathway (2013, Homo sapiens)
• Anti-quiescence network mediated by the Myc-miR-22 pathway (2013, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Presence of a diversity of Alu-mediated events in genes involved in apoptosis (2013, NA)
• The proposed signalling pathway involved in the prevention of cardiac hypertrophy by AT1 receptor blockade (2013, NA)
• METH-regulated genes in METH-pretreated rats (2013, Danio rerio,Scombridae gen. sp.,Regulus ignicapilla,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Sequoia sempervirens,Homo sapiens)
• Precursor of myostatin is promyostatin and consists of a propeptide that binds to myostatin noncovalently to form an inactive complex (2013, NA)
• Insulin or insulin-like growth factor 1 (IGF-1) binds to its receptor and activates the receptor tyrosine kinase (2013, NA)
• VPS4B downregulation increases the expression of mitochondrial fatty acid Beta-oxidation related proteins and down regulates the expression of glycolysis related proteins in SKBR3 cells (2013, NA)
• Proposed signaling pathway (2013, Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Oryza sativa)
• Main synaptic signaling mechanisms of endocannabinoid and hypocretinergic systems (2013, NA)
• From photomorphogenesis to cancer (2013, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• Linking JNK-STAT3-Akt signaling axis to EZH2 phosphorylation (2013, NA)
• PI3K-Akt pathway regulates polycomb group protein and stem cell maintenance (2013, NA)
• Calcium channels in T cells (2013, NA)
• De novo purine biosynthetic pathway in humans (2013, Homo sapiens)
• Past Visits Present: TCF/LEFs Partner with ATFs for Beta-Catenin–Independent Activity (2013, NA)
• Biochemical changes during EMT in fibrosis (2013, Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,NA)
• Cavin-3 regulates caveolae signalling (2013, NA)
• Schematic representation of the sessile and traditional serrated pathways (2013, NA)
• Natural killer cell cytotoxicity (NKCC) (2013, NA)
• The mechanisms by which IL-8 inhibits the signaling pathway of the B2AR in ATII cells (2013, Homo sapiens,Rattus norvegicus)
• Possible mechanisms of autophagy in mammalian cells (2013, Saccharomyces cerevisiae,Solanum nigrum,Boesenbergia rotunda,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus,Drosophila melanogaster,prion,Equus asinus x Equus caballus)
• Simplified outline showing key proteins within the extrinsic and intrinsic apoptotic pathways in response to extra- and intracellular stress (2013, Saccharomyces cerevisiae,Solanum nigrum,Boesenbergia rotunda,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus,Drosophila melanogaster,prion,Equus asinus x Equus caballus)
• Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice (2013, NA)
• Regulation of cellular metabolism by p53 (2013, NA)
• Proposed biosynthetic pathway for antimycins (2013, Streptomyces coelicolor,Streptomyces lividans,Streptomyces albus,Streptomyces albus J1074,Streptomyces hygroscopicus subsp. jinggangensis 5008,Streptomyces blastmyceticus,Streptomyces sp. LaPpAH-202,Streptomyces hygroscopicus subsp. jinggangensis TL01,Streptomyces griseoflavus Tu4000,Streptomyces sp. TOR3209,Streptomyces sp. CNY228,Streptomyces sp. 303MFCol5.2,Streptomyces sp. SM8,Streptomyces gancidicus BKS 13-15,Streptomyces sp. NRRL 2288,Planomonospora alba,Streptomyces ambofaciens ATCC 23877,Streptomyces odorifer,Microbispora corallina,Homo sapiens,Mus musculus,Candida albicans,uncultured actinomycete,catfish,Acromyrmex octospinosus)
• The metalloproteases meprin A and meprin B: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis (2013, NA)
• NFKB: A Coordinator for Epigenetic Regulation by MLL (2013, NA)
• Ingenuity pathways analysis canonical pathway IGF1 signaling This figure shows the IGF1 signaling pathway, with significantly upregulated genes in red, downregulated genes in green, and genes that did not meet our criteria for significance in gray (2013, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• EGFR pathway and downstream signaling pathways, including KRAS (2013, NA)
• Hemodynamic and Neuropathological Analysis in Rats with Aluminum Trichloride-Induced Alzheimer's Disease (2013, Oryza sativa,herbal medicine,Ginkgo biloba,Dipsacus asper,Mus musculus,Rattus norvegicus,Homo sapiens)
• Nitrosative/Oxidative Stress Conditions Regulate Thioredoxin-Interacting Protein (TXNIP) Expression and Thioredoxin-1 (TRX-1) Nuclear Localization (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Adenoviridae,vectors,Campanula medium)
• Connection between learning and DNA repair is made by p300.p300 is involved in G-protein signaling (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Taeniopygia guttata)
• Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Interaction of drug and signaling pathway in relevance to depression.Sex steroid hormones serve as an example (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Diagram of BA action in targeting pathways involved in cell apoptosis and death (2013, NA)
• Two reversing pathways between the vehicle and baicalin groups (2013, NA)
• Ingenuity Pathway Analysis (IPA) of genes differentially expressed in ECb vs (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECe vs (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Ingenuity Pathway Analysis (IPA) of genes differentially expressed in LRECb vs (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults (2013, Homo sapiens)
• Subnetwork 1 and 5 of 6 networks in vehicle group (2013, NA)
• Subnetworks 1, 2, and 4 of 9 networks in baicalin group (2013, NA)
• Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy (2013, NA)
• Role of aryl hydrocarbnon receptor (AHR) signalling on CD4+ T cells (2013, NA)
• Regulation of autophagy in response to stress (2013, NA)
• Proteolytic processing of the amyloid precursor protein (APP) and Notch (2013, NA)
• miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1 (2013, NA)
• Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma (2013, Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Potential mechanism of AICD-mediated gene regulation (2013, NA)
• TNF Signals through TNFR1 and TNFR2 receptors (A) but abnormalities in this signaling pathway in autoimmunity (B) can favor a pathway of selective apoptosis due to a variety of protein signaling defects (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Papio anubis)
• Cell-cycle and DNA repair (2013, Diaporthe sclerotioides,Arachis hypogaea,Pisum sativum,Phaseolus vulgaris,Lens culinaris,Vigna angularis,Phaseolus acutifolius,Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens,Helicobacter pylori)
• OSM receptors and signaling (2013, NA)
• Hh signalling and cancer: Growth factors can increase the concentration of ligand which prevents the inhibitory effect of PTCH (2013, Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Almost all Theileria annulata proteins involved in glycolysis and citric acid cycle were identified in the study (2013, NA)
• Elementary Flux Modes Analysis of Functional Domain Networks Allows a Better Metabolic Pathway Interpretation (2013, NA)
• Novel Pancreatic Endocrine Maturation Pathways Identified by Genomic Profiling and Causal Reasoning (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,Tragelaphus oryx)
• Induction of CCL8/MCP-2 by Mycobacteria through the Activation of TLR2/PI3K/Akt Signaling Pathway (2013, NA)
• Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients (2013, Armoracia rusticana,Sequoia sempervirens,Eucalyptus intertexta,Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Altered energy metabolism in cancer (2013, NA)
• An illustrative model of amelioration of ER stress–induced Beta-cell apoptosis by GKA (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Models for intrinsic signaling by BST2 and for BST2 as a virus sensor (2013, Homo sapiens,Human immunodeficiency virus 1)
• Interface between the HER2 signaling network and apoptotic control centers (2013, NA)
• Schematic model of IFN-induced apoptosis in WISH cells (2013, NA)
• Proposed model of M-CSF-mediated organization of the osteoclast cytoskeleton (2013, Mus musculus,Homo sapiens)
• Proposed metabolic model for syntrophic growth of D (2013, NA)
• NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria (2013, NA)
• Ingenuity pathway analysis (2013, NA)
• Possible potential role of free fatty acid (FFA), hypoxia, reactive oxygen species (ROS), and PTEN in the development of NAFLD and NASH based on the predominant PI3K/AKT/GSK3 pathways (2013, NA)
• PI3K/AKT/GSK3/mTOR signaling (2013, NA)
• Typical signal transduction from the ErbB4:ErbB1 and ErbB4:ErbB4 complex (2013, Human papillomavirus type 16,Vaccinia virus,Variola virus,Cowpox virus,Deltapapillomavirus 4,Bovine papillomavirus,Human papillomavirus type 6,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Corynebacterium phage gamma)
• Nephrin-adaptors complex (2013, NA)
• Unfolded protein response (UPR) is activated in the autosomal dominant retinitis pigmentosa (adRP) retina and proposed to be a target for modulating the rate of retinal degeneration (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Hippospongia communis,Homo sapiens,Oryza sativa,Adeno-associated virus)
• Signal transduction pathway through TLR (2013, Neisseria gonorrhoeae,Metamycoplasma hominis,Ureaplasma urealyticum,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida albicans,Human papillomavirus,Trichomonas vaginalis)
• Proposed metabolic models for syntrophic growth of D (2013, Methanococcus maripaludis,Methanospirillum hungatei,Oleidesulfovibrio alaskensis G20)
• Inflammation Regulates TMPRSS6 Expression via STAT5 (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Microfluidic Generated EGF-Gradients Induce Chemokinesis of Transplantable Retinal Progenitor Cells via the JAK/STAT and PI3Kinase Signaling Pathways (2013, NA)
• Antioxidant defense against HP toxicity (2013, NA)
• Model to illustrate the proapoptotic potential of SARM following T-cell immune response (2013, Influenza A virus,unidentified influenza virus,West Nile virus,Porcine reproductive and respiratory syndrome virus,Drosophila melanogaster,Oryctolagus cuniculus,Caenorhabditis elegans,Canis lupus familiaris,Diaporthe sclerotioides,Vasconcellea candicans,Homo sapiens,Mus musculus)
• Role of activated Th17 cells during Con A-induced hepatitis (2013, Staphylococcus aureus,Pseudomonas aeruginosa,Helicobacter hepaticus,Mus musculus,Rattus norvegicus,Hepatitis B virus,Human alphaherpesvirus 1,Candida albicans 23R,Candida albicans 23P,Homo sapiens)
• Proposed synergistic mechanisms for induction of mitotic cell death in endometrial cancer cells with mutant p53 (2013, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Pathway of ethanol metabolism (2013, Mus musculus,Rattus norvegicus,Hepatitis B virus,Human gammaherpesvirus 4,Homo sapiens,Drosophila melanogaster,Avena sativa)
• Toll-like receptor 4 signaling pathway in alcohol consumption (2013, Mus musculus,Rattus norvegicus,Hepatitis B virus,Human gammaherpesvirus 4,Homo sapiens,Drosophila melanogaster,Avena sativa)
• NFkB activation pathway and its different inhibition steps (2013, Saccharomyces cerevisiae,Panax ginseng,Curcuma longa,Salvia miltiorrhiza,Citrus x paradisi,Tanacetum parthenium,Saururus cernuus,Streptomyces sp.,Streptomyces echinatus,Homo sapiens,Mus musculus)
• HIF1A activation can be inhibited at different steps along the pathway (2013, Saccharomyces cerevisiae,Panax ginseng,Curcuma longa,Salvia miltiorrhiza,Citrus x paradisi,Tanacetum parthenium,Saururus cernuus,Streptomyces sp.,Streptomyces echinatus,Homo sapiens,Mus musculus)
• The pathway linking hypoxia and HIF1A activation with inflammation and tumor progression (2013, Saccharomyces cerevisiae,Panax ginseng,Curcuma longa,Salvia miltiorrhiza,Citrus x paradisi,Tanacetum parthenium,Saururus cernuus,Streptomyces sp.,Streptomyces echinatus,Homo sapiens,Mus musculus)
• Dual functions of Smad2 in the maintenance of hESC and mEpiSC pluripotency (2013, NA)
• BMP signalling pathway (2013, Mus musculus,Homo sapiens)
• Metabolic Adaption of Ethanol-Tolerant Clostridium thermocellum (2013, NA)
• Signaling pathways in melanoma.Notes: Oncoprotein Ras activates both the MAPK and PI3K/Akt survival pathways (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Human papillomavirus)
• Hydrogen sulphide inhibits Ca2+ release through InsP3 receptors and relaxes airway smooth muscle (2013, NA)
• BiP as master regulator of the Unfolded Protein Response (2013, Escherichia coli,Streptomyces violaceusniger,Streptomyces versipellis,Homo sapiens,Mus musculus)
• Biosynthetic pathway of l-valine and by-products of C (2013, NA)
• Loss of REST in patient leiomyoma cells resulted in the expression of the G protein coupled receptor GPR10 and activation of the AKT/MTOR signaling pathway (2013, NA)
• MicroRNAs as novel immunotherapeutics (2013, NA)
• Working model for the synergistic effect of TPL and ATF on tumour cells (2013, Saccharomyces cerevisiae,Armoracia rusticana,Diaporthe sclerotioides,Tripterygium wilfordii,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Schematic diagram of the adiponectin-AMPK pathway in glomerular cells (2013, NA)
• miR-486 sustains NFKB activity by disrupting multiple NFKB-negative feedback loops (2013, NA)
• Hh signal transduction in Drosophila and mammalian systems (2013, NA)
• Proposed signaling pathway for basal and BK-mediated eNOS activation in inflamed endothelium (2013, Homo sapiens)
• Two phosphoinositide cycles regulate aspects of lysosome function (2013, NA)
• Schematic representation and overview of PTEN/PI3K/AKT signaling and a model of the mechanism of peroxisome proliferator-activated receptor (PPAR) action (2013, Candida dubliniensis,Curcuma longa,Salvia rosmarinus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila simulans)
• Host Susceptibility Factors to Bacterial Infections in Type 2 Diabetes (2013, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Burkholderia pseudomallei,Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides)
• Enriched canonical pathways of miRNA target genes (2013, NA)
• Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs (2013, NA)
• Cholinergic anti-inflammatory pathway (2013, Bos taurus,Oryctolagus cuniculus,Equus caballus,Equus asinus,Bison bonasus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and treated discs (2013, NA)
• Functional gene networks identified using Ingenuity Pathway Analysis (IPA) from differentially expressed genes between the control and experimental discs (2013, NA)
• Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation (2013, NA)
• Blocking the transforming growth factor B (TGFB) signalling pathway (2013, Homo sapiens,Mus musculus,Bos taurus,Danio rerio,Papaya ringspot virus)
• Normal, physiological insulin signaling transduction (left) and an altered pathway following insulin withdrawal (right) in adult hippocampal neural stem cells (2013, NA)
• Localization of ciliary proteins related to polycystic kidney (2013, Homo sapiens,Mus musculus,Danio rerio,Aspergillus nidulans)
• Role of G6PD in both antioxidant and oxidant formation pathways (2013, NA)
• Comprehensive VCell modeling of the actin cytoskeleton (2013, NA)
• Rapid, Facile Detection of Heterodimer Partners for Target Human G-Protein-Coupled Receptors Using a Modified Split-Ubiquitin Membrane Yeast Two-Hybrid System (2013, NA)
• Eicosanoid biosynthetic pathway and its activation by RTK/GFR → ERK1/2 signaling (2013, NA)
• Cadmium Induces Apoptosis in Pancreatic Beta-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation (2013, NA)
• Proposed signalling interactions between C-type natriuretic peptide (CNP) and mechanical loading in chondrocytes (2013, NA)
• Inhibitory effects of BMS-345541 or/and wortmannin on LPS-induced NFKB/PI-3K and apoptosis in primary human chondrocytes in vitro (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus caballus,Mus musculus,Escherichia coli,Cavia porcellus,Escherichia coli Nissle 1917,Homo sapiens)
• Litopenaeus vannamei Sterile-Alpha and Armadillo Motif Containing Protein (LvSARM) Is Involved in Regulation of Penaeidins and antilipopolysaccharide factors (2013, Drosophila melanogaster,Caenorhabditis elegans,Aedes aegypti,Crassostrea gigas,Branchiostoma lanceolatum,Penaeus vannamei,Daphnia pulex,Penaeus monodon,Penaeus chinensis,Carcinoscorpius rotundicauda,Dengue virus,Shrimp white spot syndrome virus,White spot syndrome virus,Bos taurus,Danio rerio,Xenopus tropicalis,Vibrio harveyi,Panthera tigris,Vibrio alginolyticus,Homo sapiens,vectors,Eucalyptus intertexta)
• HDAC6 Deacetylase Activity Is Required for Hypoxia-Induced Invadopodia Formation and Cell Invasion (2013, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Homo sapiens,Mus musculus)
• Agonist binding to MORs can result in the activation of multiple downstream pathways (2013, NA)
• Modeling the genetic basis for human sleep disorders in Drosophila (2013, Homo sapiens,Drosophila melanogaster,Agaricus bisporus)
• Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish (2013, Danio rerio,Xenopus laevis,teleost fish,Merluccius merluccius,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Tobacco etch virus)
• Antcin C-induced upregulation of antioxidative gene expression via the Nrf2/ARE signaling pathway and suppression of AAPH-induced apoptosis in human hepatic HepG2 cells (2013, NA)
• Diagram of the cell signaling pathway which was involved in NVU protection of XXMD against cerebral injury following focal cerebral ischemia and reperfusion (2013, Armoracia rusticana,herbal medicine,Panax ginseng,Raphanus sativus,Apocynum venetum,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Active killing of motoneurons through death receptors under pathological context (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Human alphaherpesvirus 1,NA)
• Beta-catenin dependent and independent Wnt signaling pathways (2013, NA)
• Angiogenic signalling pathways and (b) proposed mechanism for high-frequency EF regulation of angiogenic response (2013, NA)
• T-cell death during HIV-1 infection (2013, Human immunodeficiency virus 1,Human immunodeficiency virus,Human T-cell leukemia virus type I,Simian immunodeficiency virus,Homo sapiens,Macaca mulatta,Mus musculus,Corynebacterium phage gamma,Simian-Human immunodeficiency virus,Catopsilia pomona)
• The canonical Wnt signaling pathway (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Gallus gallus)
• BRCA pathway showing the role of BRCA1 in DNA damage response and crosstalk with other biological pathways, notably the P53 pathway.Notes: Double circles indicate complex interactions involving multiple genes (2013, Homo sapiens,Mus musculus)
• CHEK kinase pathway showing the role of CHEK proteins in cell cycle checkpoint control, and crosstalk with other pathways notably the P53 and BRCA pathways.Notes: Double circles indicate complex interactions involving multiple genes (2013, Homo sapiens,Mus musculus)
• NELL-1 signaling pathway (2013, NA)
• Possible implication of MMPIs in the treatment of ovarian cancer (2013, NA)
• High-fluence UV radiation activates UVR8 independent stress pathway and cell death (2013, NA)
• Overview about currently tested Hedgehog pathway inhibitors and their mode of action (2013, NA)
• Characterization of Negative Feedback Network Motifs in the TGFB Signaling Pathway (2013, Homo sapiens,Mus musculus,Bos taurus)
• Negative Feedback Network Motifs in the TGFB Signaling Pathway (2013, Homo sapiens,Mus musculus,Bos taurus)
• Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct (2013, Xenopus laevis,Dipturus trachyderma,Homo sapiens,Mus musculus,Bos taurus,Eucalyptus intertexta)
• Pathways involved in endocrine resistance (2013, NA)
• The LNG1 data set (2013, NA)
• Genome-Wide Transcriptional Response of Silkworm (Bombyx mori) to Infection by the Microsporidian Nosema bombycis (2013, NA)
• Convergence of metabolic pathway for acetaldehyde and dopamine (2013, NA)
• Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival (2013, NA)
• Major oncogenic signaling pathway alterations in urothelial carcinoma (2013, Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG,Citrus medica)
• Genome Wide Analysis Reveals Zic3 Interaction with Distal Regulatory Elements of Stage Specific Developmental Genes in Zebrafish (2013, Danio rerio,Xenopus laevis,teleost fish,Merluccius merluccius,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Tobacco etch virus)
• Hypothetical model illustrates the E2-ERA signaling pathway involving both genomic and extranuclear signaling pathways (2013, NA)
• Dual-view setup of the enRoute visualization technique (2013, Homo sapiens,Mus musculus)
• Signaling mechanisms important for endocrine resistance and which are currently targeted in clinical trials, combined with aromatase inhibitors (2013, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Equus caballus,Microbacterium aurantiacum)
• Proposed signaling pathway (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells (2013, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Eucalyptus intertexta,Homo sapiens,Mus musculus)
• Several flavonoid compounds also target the Fyn/Src signaling pathway (2013, NA)
• EGFR activation of the Ras/Raf/MEK/MAPK pathway (2013, NA)
• Novel signaling pathways involved in apo(a)-mediated effects on vascular endothelial cells (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Armoracia rusticana,Nicotiana tabacum,Candida dubliniensis,Homo sapiens,Mus musculus)
• Simplified scheme summarizing the effect of aging and MPTP on Nrf2-ARE axis dysfunction-mediated Wnt/Beta-catenin signaling dysregulation in NPCs associated with neurogenic impairment (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Human intestinal innate myeloid cells (2013, Homo sapiens,Mus musculus,Bifidobacterium breve)
• General scheme of EGFR activation (2013, NA)
• Proposed mechanism for MTX-induced melanosome transport in melanoma (2013, Homo sapiens,Mus musculus)
• Dual role of Nrf2 in tumorigenesis (2013, Homo sapiens,Mus musculus)
• Consequences of oxidative stress on proteins, the proteasomal system and transcription factors (2013, NA)
• Common signaling pathways of H2S and NO: H2S and NO mediated vascular remodeling aspects through common pathway that include VEGF, HIF-1A, PI3K/AKT upregulated by H2S (2013, NA)
• Schematic overview of three pathways of caspase-dependent apoptosis (2013, unidentified influenza virus,Respiratory syncytial virus,Human orthopneumovirus,Bovine orthopneumovirus,Murine orthopneumovirus,Homo sapiens,Mus musculus,Bos taurus)
• Transcription factors predicted to be inhibited by battlefield-like stressors and their targets among stress-modulated genes (2013, NA)
• Stress-suppressed genes involved in antigen presentation and synapse formation (2013, NA)
• Altered Cytokine Gene Expression in Peripheral Blood Monocytes across the Menstrual Cycle in Primary Dysmenorrhea: A Case-Control Study (2013, NA)
• Functional partners of RB1 protein through STRING database (2013, NA)
• Pathway Protection Loop (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Human immunodeficiency virus 1,synthetic gene)
• GprA/B mediated signalling resulting in sexual development of A (2013, Saccharomyces cerevisiae,Triticum aestivum,Olea europaea,Aspergillus fumigatus,Aspergillus nidulans,Aspergillus niger,Zingiber officinale,Neurospora crassa,Aspergillus flavus,Aspergillus oryzae,Aspergillus terreus,Aspergillus parasiticus,Aspergillus clavatus,Schizophyllum commune,Aspergillus carbonarius,Aspergillus awamori,Aspergillus fischeri,Aspergillus westerdijkiae,Aspergillus sojae,Aspergillus tamarii,Aspergillus nomiae,Aspergillus penicillioides,Talaromyces flavus,Penicillium paneum,Homo sapiens,Bos taurus,NA,NA)
• mTOR signaling pathway (#hsa04150) (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Human immunodeficiency virus 1,synthetic gene)
• Antigen processing and presentation (APP) pathway (#hsa04612) (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Human immunodeficiency virus 1,synthetic gene)
• Fatty Acid Elongation and Cuticular Wax BiosynthesisPathways for the formation in epidermal cells of very long chain fatty acyl-CoAs (VLCFAs) and cuticular waxes (2013, NA)
• Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT (2013, NA)
• Molecules involved during pancreatic development (2013, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Plasmid pTF1)
• Signaling diagram for AC5 mediating cardiac stress and longevity (2013, NA)
• The mechanisms of Wnt/Beta-catenin pathway repression by 1,25(OH)2D3 in human colon carcinoma cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• Regulation of metabolism in maligant gliomas (2013, NA)
• Proposed model for the role of lncRNAs in RB pathway (2013, Mus musculus,Cricetus cricetus,Homo sapiens,Hepatitis B virus,Ziziphus mauritiana,NA)
• Suppression of regulatory B cells identified in human and animal (2013, NA)
• Regulation of the EMT Pathway and Tec kinase signaling in Calu-6 compared to U1752 (2013, Homo sapiens)
• Lipopolysaccharide (endotoxin) signaling pathway (2013, NA)
• Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA (2013, NA)
• HDL metabolic pathways and current drugs under development (2013, Homo sapiens,Mus musculus,Bos taurus,Oryctolagus cuniculus,Cricetus cricetus,Chlorocebus aethiops,Glycine max,Adeno-associated virus,Trypanosoma brucei brucei)
• EGFR monoclonal antibodies (MoABs) cetuximab/panitumab, and BRAF inhibitors in BRAF mutated colorectal cancer (2013, NA)
• Schematic overview of the transforming growth factor (TGF)B signaling pathway (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Regulation of autophagy pathways and targets for modulating autophagy by drugs/compounds (2013, NA)
• The Akt Pathway Reveals a Novel Link with PERK/eIF2A, which Is Relevant during Hypoxia (2013, NA)
• Morphoproteomic Profiling of the Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Desmoplastic Small Round Cell Tumor (EWS/WT1), Ewing’s Sarcoma (EWS/FLI1) and Wilms’ Tumor(WT1) (2013, Homo sapiens)
• IL-6-STAT3 signaling and premature senescence (2013, NA)
• MYD88—an intriguing link between WM and natural effector IgM+ memory cells (2013, NA)
• Oxidative metabolism in cancer (2013, NA)
• Current model for replication-independent ICL repair (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Schizosaccharomyces pombe,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Bombyx mori,Calloplesiops altivelis,Escherichia coli,Haloferax volcanii,Homo sapiens,Mus musculus,synthetic construct)
• Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Schizosaccharomyces pombe,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Bombyx mori,Calloplesiops altivelis,Escherichia coli,Haloferax volcanii,Homo sapiens,Mus musculus,synthetic construct)
• A non-canonical JAK-STAT pathway in IFN therapy of poxvirus infection and multiple sclerosis (2013, NA)
• Full Transcriptome Analysis of Early Dorsoventral Patterning in Zebrafish (2013, NA)
• TSC-mTOR pathway regulates macrophage polarization (2013, Candida dubliniensis,Helianthus annuus,Homo sapiens,Mus musculus,Ovis aries)
• Supposed mechanism of EVE-induced EMT (2013, NA)
• Accumulation of Splice Variants and Transcripts in Response to PI3K Inhibition in T Cells (2013, Mus musculus,Rattus norvegicus,Human T-cell leukemia virus type I,Measles morbillivirus,Deltapapillomavirus 4,Sigmodon hispidus,Diaporthe sclerotioides,Derris trifoliata,Homo sapiens,NA)
• Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Campylobacter jejuni,Citrobacter rodentium,Mycobacterium avium,Clostridioides difficile CD3,Candidatus Sodalis pierantonius str. SOPE,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Aspergillus fumigatus,Coxsackievirus,Entamoeba histolytica,Derris trifoliata,unidentified virus,Homo sapiens,Canis lupus familiaris)
• Reconstructing the interactions among different modules of the MAPK pathway (2013, Homo sapiens)
• Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer (2013, NA)
• UVA and UVB Irradiation Differentially Regulate microRNA Expression in Human Primary Keratinocytes (2013, Bos taurus,Pekania pennanti,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Dipturus trachyderma)
• Toll-Like Receptor (TLR)-Associated Sequence Variants and Prostate Cancer Risk among Men of African Descent (2013, NA)
• Expression Microarray Meta-Analysis Identifies Genes Associated with Ras/MAPK and Related Pathways in Progression of Muscle-Invasive Bladder Transition Cell Carcinoma (2013, NA)
• Combining Machine Learning Systems and Multiple Docking Simulation Packages to Improve Docking Prediction Reliability for Network Pharmacology (2013, Homo sapiens)
• Focal adhesion signaling pathway highlighting those genes that are differentially expressed compared to untreated control ovaries and identifying by color the treatment group(s) from which the differentially expressed genes came (2013, NA)
• Pathways regulated in PKD are influenced by tolcapone (2013, NA)
• microRNAs Involved in Regulating Spontaneous Recovery in Embolic Stroke Model (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans,Diaporthe sclerotioides)
• Short osmotic stress model (2013, NA)
• Coordinate MicroRNA-Mediated Regulation of Protein Complexes in Prostate Cancer (2013, Homo sapiens,Pekania pennanti)
• Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling (2013, NA)
• Schematic model of cancer-derived IgG to enhance cell growth and proliferation through inducing the production of a low level of ROS (2013, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Escherichia coli)
• Why stress is BAD for cancer patients (2013, NA)
• Alzheimer’s disease and insulin resistance: translating basic science into clinical applications (2013, Homo sapiens)
• Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis (2013, NA)
• Orchestration of CD8 T cell differentiation by the PI3K/Akt pathway (2013, Homo sapiens,Mus musculus,NA)
• Activation and function of PI3K/Akt signaling in CD8 T cell (2013, Homo sapiens,Mus musculus,NA)
• Schematic model of autoregulation of BMI1 (2013, NA)
• An overview of EGFR and Wnt/Beta-catenin signaling (2013, Homo sapiens)
• Schematic representation showing various signaling pathways regulating distinct aspects of a tumor and current status of their therapeutic exploitation (2013, Homo sapiens)
• Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer (2013, Homo sapiens)
• Transcriptome Analysis Reveals Novel Entry Mechanisms and a Central Role of SRC in Host Defense during High Multiplicity Mycobacterial Infection (2013, NA)
• HCV life cycle and points of intervention (2013, Hepatitis B virus,Non-A non-B hepatitis virus,Hepatitis C virus genotype 1,Hepatitis C virus genotype 2,Homo sapiens,Canis lupus familiaris,Equus caballus,Pan troglodytes,Mus musculus,NA,NA)
• Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways (2013, NA)
• Whole Genome Gene Expression Analysis Reveals Casiopeína-Induced Apoptosis Pathways (2013, NA)
• Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction (2013, NA)
• Down-regulation of the clotting cascade by the protein C pathway (2013, NA)
• Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction (2013, NA)
• Canonical (yellow background) and non-canonical (red background) Wnt/Beta-catenin signaling pathways are related to mechanical elements and actions responsible for cell polarization, migration and tissue organization (2013, NA)
• Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response (2013, NA)
• Scheme showing the potential molecular events induced in cancer cells in the hypoxic tumour microenvironment (2013, NA)
• PPARB Regulates Liver Regeneration by Modulating Akt and E2f Signaling (2013, NA)
• The TLR9-Notch ligand (dll4) on Mycobacterium-dependent granuloma formation (2013, NA)
• mTOR signalling pathway (2013, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Fumigaclavine C-induced apoptosis in MCF-7 breast cancer cells through the mitochondrial pathway (2013, NA)
• Coordinately up-regulated genes of chemokine signaling pathway in monocytes from the VIR group (VIR versus BDL) (2013, Human immunodeficiency virus 1,Human immunodeficiency virus,Vaccinia virus,Spleen focus-forming virus,Homo sapiens,Mus musculus,Drosophila melanogaster,Candida dubliniensis)
• Working model for the NOX dependence of TNFA production by the liver following I/R injury (2013, NA)
• FAK-mediated growth of C2C12 cells in response to IGF-I (2013, Mus musculus,Homo sapiens)
• Network of the mechanistic Target of Rapamycin (mTOR) signaling pathway (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Schematic of the events within the granulosa cell depicting how the interactions of LHR and adiponectin might occur (2013, NA)
• The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro (2013, NA)
• The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro (2013, NA)
• TGFB signaling pathway (2013, Mus musculus,Rattus norvegicus,Bos taurus,Human papillomavirus,Human papillomavirus type 16,Mustela lutreola,Homo sapiens)
• Schematic model of raft-mediated Akt signaling in the regulation of cell survival and death in MCL cells during edelfosine treatment (2013, NA)
• Relevance of Trehalose in Pathogenicity: Some General Rules, Yet Many Exceptions (2013, NA)
• Upstream regulators and their target molecules in datasets as identified by Ingenuity Pathway Analysis (IPA) (2013, NA)
• The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro (2013, NA)
• Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin (2013, NA)
• Genome-Wide Pathway Analysis Reveals Different Signaling Pathways between Secreted Lactoferrin and Intracellular Delta-Lactoferrin (2013, NA)
• The potential disruption of hepatic GH signaling pathways by MC (2013, NA)
• IIS/TOR signaling pathway in fat body and the central nervous system of Drosophila (2013, Drosophila melanogaster,Bombyx mori,Apis mellifera,Aedes aegypti,Manduca sexta,Tribolium castaneum,Blattella germanica,Oryctes rhinoceros,Pyrrhocoris apterus,Junonia coenia,Onthophagus taurus,Onthophagus acuminatus,Apis mellifera carnica,Cyclommatus metallifer,Gnatocerus cornutus,Homo sapiens,Saccharomyces cerevisiae)
• Transcriptomic Analysis of Insulin-Sensitive Tissues from Anti-Diabetic Drug Treated ZDF Rats, a T2DM Animal Model (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Erythroxylum coca)
• ErbB2-Dependent Chemotaxis Requires Microtubule Capture and Stabilization Coordinated by Distinct Signaling Pathways (2013, NA)
• Differential signaling pathways activated by B1ARs and B2ARs in cardiomyocytes (2013, NA)
• Abundance distribution of cell cycle proteins (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Schizosaccharomyces pombe,Schizosaccharomyces pombe 972h-,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Escherichia coli)
• Networks showing metabolic pathways differentially modulated between H and L groups (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Pieris brassicae)
• Regulation of smooth muscle contractility (2013, NA)
• Important molecular pathways and drug targets in RCC (2013, NA)
• DNA end resection (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Schizosaccharomyces pombe,vectors,unidentified shuttle vector,Homo sapiens,Mus musculus,Escherichia coli,Xenopus laevis)
• Distinct and Atypical Intrinsic and Extrinsic Cell Death Pathways between Photoreceptor Cell Types upon Specific Ablation of Ranbp2 in Cone Photoreceptors (2013, NA)
• Diagrammatic overview of the late stages of the HIV life-cycle (2013, NA)
• AKT-mammalian target of rapapmycin (mTOR) signalling pathway (2013, NA)
• Propyl-2-(8-(3,4-Difluorobenzyl)-2′,5′-Dioxo-8-Azaspiro[Bicyclo[3.2.1] Octane-3,4′-Imidazolidine]-1′-yl) Acetate Induces Apoptosis in Human Leukemia Cells through Mitochondrial Pathway following Cell Cycle Arrest (2013, NA)
• Schematic diagram (2013, NA)
• Insights into TREM2-related signaling using data-driven network constructions and information provided by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (2013, Homo sapiens,Pan troglodytes,Mus musculus,Eucalyptus intertexta)
• Interaction of gallium with cellular iron metabolism (2013, Homo sapiens)
• Effector intercrossing network under physiological condition (2013, NA)
• Neuroprotection of histone deacetylase inhibitors (HDI) Scriptaid against traumatic brain injury (TBI) (2013, Mus musculus,Homo sapiens)
• Phosphatidylinositol-3-kinase/Akt signaling pathway (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Canis lupus familiaris)
• Diagram showing Na-K-ATPase control of cell function by ouabain via its ion transport and signaling functions (2013, NA)
• Molecular details of BAFF/BAFFR-mediated activation of NFKB2 signaling pathway (2013, Homo sapiens,Mus musculus,NA)
• mRNA-seq Analysis of the Gossypium arboreum transcriptome Reveals Tissue Selective Signaling in Response to Water Stress during Seedling Stage (2013, Gossypium arboreum,Homo sapiens)
• Lysine-Specific Demethylase 1 (LSD1/KDM1A) Contributes to Colorectal Tumorigenesis via Activation of the Wnt/Β-Catenin Pathway by Down-Regulating Dickkopf-1 (DKK1) (2013, NA)
• Model showing the effects of PP2A in SLE T-cells (2013, NA)
• Modulation of Insulin-Like Growth Factor-1 Receptor and its Signaling Network for the Treatment of Cancer: Current Status and Future Perspectives (2013, NA)
• HIV-related neuropathic pain pathway (2013, NA)
• Pathways of relationships identified by feeding gene expression patterns identified in erythroid progenitors to the Ingenuity software (2013, Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Mus musculus,Drosophila melanogaster,Spleen focus-forming virus)
• Current putative prognostic biomarkers in glioblastoma (2013, NA)
• Molecular pathways affected by CR and irradiation (2013, NA)
• Summary of regulatory relationships among genes controlling protein phospho-modulation at egg activation (2013, NA)
• Interplay between regulatory T cells and metabolism in immune regulation (2013, NA)
• Predicted pathways by the Ingenuity Pathway Analysis software (IPA) according to microarrays results in peripheral blood mononuclear cells (PBMCs) (2013, Olea europaea,Sequoia sempervirens,Theobroma cacao,Homo sapiens,Rattus norvegicus,Sus scrofa)
• HMGB1 in the tumor microenvironment and hypothesis of HMGB1 functioning via NF-kB and epigenetic pathways (2013, NA)
• ER signaling, targeted therapies, and endocrine resistance (2013, Homo sapiens)
• LXRs and prostate physiology: potential beneficial actions of LXRs over prostate cancer (2013, Homo sapiens)
• Regulatory Networks and Complex Interactions between the Insulin and Angiotensin II Signalling Systems: Models and Implications for Hypertension and Diabetes (2013, NA)
• Regulation of cardiac myofilament contractility by pharmacological modulation of the ANG II type 1 receptor (AT1R) (2013, Rattus norvegicus,Homo sapiens)
• MOMA analysis identifies double-gene knockouts in primary metabolism that funnel carbon toward DHA (2013, Saccharomyces cerevisiae,Nicotiana tabacum,Glycine max,Diaporthe sclerotioides,Hordeum vulgare,Aspergillus nidulans,Artemisia annua,Scheffersomyces stipitis,Escherichia coli,Corynebacterium glutamicum,Chlorobaculum tepidum,Haemophilus influenzae Rd KW20,Homo sapiens,Rattus norvegicus,unidentified influenza virus)
• Mathematical Model for MicroRNA in Lung Cancer (2013, NA)
• Perturbed pattern of genes in the peroxisome proliferation activator receptor (PPAR) signaling pathway by DEX administration (ethanol plus DEX vs (2013, NA)
• Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway (2013, unidentified influenza virus,Human rotavirus,Rotavirus A,Porcine rotavirus,Bovine rotavirus,Murine rotavirus,Simian rotavirus,Bovine rotavirus strain UKG6,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens)
• Ingenuity pathway analysis (IPA)-identified top networks affected by Cd-induced oxidation of proteins (2013, NA)
• Loss and Retention of RNA Interference in Fungi and Parasites (2013, NA)
• Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry (2013, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Danio rerio)
• Putative role of VHL-HIF-EPO pathway in RCC progression (2013, Homo sapiens,Mus musculus)
• Novel GPCR-based signaling mechanisms in ASM (2013, Homo sapiens)
• Metabolic regulation in the insulin resistant heart (2013, NA)
• Canonical pathways (2013, Rattus norvegicus,Homo sapiens)
• The potential role of MuRF1 in atrophy induced gene expression pathways (2013, Mus musculus,Homo sapiens)
• Actions of Nec-1 and its derivatives in a mouse system (2013, NA)
• Subnetworks identified from (a) Loi et al (2013, NA)
• Subnetworks identified from (a) Wang et al (2013, NA)
• Signal transduction pathways and activation of the innate immune response (2013, NA)
• The variety of stimuli that can up-regulate NKG2D and DNAM-1 ligands (2013, NA)
• HMGB1-TLR4 signaling mediates liver I/R injury (2013, NA)
• Cell mechanism linking impaired glucose utilization in type 2 diabetes and cardiovascular disease (2013, NA)
• Steroid hormone synthesis pathways in the adrenal gland and testis (2013, NA)
• Pharmacology and rationale for imatinib in the treatment of scleroderma (2013, NA)
• Cancer Genome Atlas of glioblastoma multiforme (2013, NA)
• Aerobic glycolysis, the citric acid cycle, and key glycolytic shunts (2013, NA)
• Oncogenic signals regulate each stage of translation (2013, NA)
• Effects of CYP2S1 depletion on arachidonic acid metabolism (2013, NA)
• Effects of CYP2S1 depletion on mTOR signaling (2013, NA)
• Cocaine, similarly to most drugs of abuse, produces long lasting brain changes, that relie on gene expression and new protein synthesis (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis)
• Proposed schematic (2013, NA)
• HER2 family pathways, targeted therapies, and treatment resistance (2013, Homo sapiens)
• AKT controls T-cell differentiation (2013, NA)
• Core pathways involved in glioblastoma multiforme (2013, NA)
• Toll-like receptor 3 (TLR3) participates in both defence and offence in host immunity to viruses (2013, West Nile virus,Punta Toro virus,Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Severe acute respiratory syndrome-related coronavirus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,DNA viruses,Enterovirus C,Human alphaherpesvirus 2,Coxsackievirus B3,Murid betaherpesvirus 1,Enterovirus A71,Encephalomyocarditis virus,Reovirus sp.,Coxsackievirus,Enterovirus,Hepatovirus A,Tick-borne encephalitis virus,Theilers encephalomyelitis virus,Coxsackievirus B4,Homo sapiens,Mus musculus,NA,NA,NA,NA)
• Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans (2013, NA)
• Leu452His Mutation in Lipoprotein Lipase Gene Transfer Associated with Hypertriglyceridemia in Mice in vivo (2013, Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Paracheirodon innesi)
• The interleukin (IL)-21 receptor signaling pathway (2013, NA)
• Interactions and feedback loops between Akt and mTOR complexes and energy consuming and energy producing processes (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,vectors,Salmonella enterica)
• Network analysis of known SLE-associated genes (2013, Nicotiana tabacum,Morchella esculenta,Homo sapiens,Mus musculus)
• Diagram showing activation of Notch signalling (2013, NA)
• Inducible antioxidant defense regulated by Nrf2/Keap1 and the antioxidant response element (2013, NA)
• Targeting the Th17 pathway (2013, NA)
• The suggested interplay between natural killer (NK), CD4+ T, B cells, and polymorphonuclear cells (PMN) during pemphigus pathogenesis (2013, NA)
• P38 MAPK in the induction of pemphigus vulgaris (PV) (2013, NA)
• Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells (2013, Mus musculus,Rattus norvegicus,Armoracia rusticana,Mundulea sericea,Homo sapiens,Bos taurus)
• Antigen processing and presentation pathway and the cell cycle pathway (2013, NA)
• PI3K/Akt/mTOR pathway (2013, Homo sapiens)
• Simplified model for NHEJ and HR (2013, NA)
• Pathway-guided treatment in prostate cancer (2013, Homo sapiens)
• Proposed role of Foxg1 in CM development (2013, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• cGMP signaling pathways (2013, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Model illustrating potential early effects of cold stress on phospholipid metabolism and de novo synthesis in Arabidopsis (2013, NA)
• The mechanism(s) by which NO‐independent sGC stimulators and sGC activators fit into the NO/sGC/cGMP pathway (2013, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets (2013, Escherichia coli,Homo sapiens)
• Main signaling pathways supposed to be activated in MEC exposed to either E (2013, Escherichia coli,Staphylococcus aureus,Homo sapiens)
• T-bet: a bridge between innate and adaptive immunity (2013, NA)
• Two branches of pathway upstream of mTORC1 (2013, NA)
• SH3BP4 is a potential tumor suppressor functioning in the amino acid-mTORC1 pathway (2013, NA)
• New and emerging treatments for estrogen receptor-positive breast cancer: focus on everolimus (2013, NA)
• Defects within components of the ECM and the TGFB signaling pathway leading to various HCTD (2013, NA)
• MTOR signaling pathway (2013, NA)
• O-GlcNAc is involved in the cellular stress response (2013, NA)
• Nutrient signaling to mTORC1 (2013, NA)
• Activation mechanism of Orai1 and STIM1 (2013, NA)
• Autophagy master regulator TFEB induces clearance of toxic SERPINA1/Alpha-1-antitrypsin polymers (2013, NA)
• Interacting partners and posttranslational modification of Orai1 and STIM1 (2013, NA)
• Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Diaporthe sclerotioides,Homo sapiens,Human papillomavirus type 16)
• Simplified model of Rac1 signaling and function in learning-induced adult neurogenesis (2013, NA)
• Emerging concepts in immunity to hepatitis C virus infection (2013, Homo sapiens,NA)
• Apoptosis signaling under ER stress conditions (2013, Mus musculus,Rattus norvegicus,Cricetulus griseus,Drosophila melanogaster,Caenorhabditis elegans,Pseudomonas aeruginosa,bacterium C-10,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Human betaherpesvirus 5)
• Glycolysis and molecular targets of glycolytic inhibitors (2013, NA)
• Molecular alterations underlying vascular neoplasias (2013, NA)
• Classical pathway of B2adrenergic receptor (B2AR) activating GAsprotein, which in turn activates the conversion of ATP in cAMP by the adenylate cyclase (AC) (2013, NA)
• Hypothetical gastrin-CCKBR signal transduction pathway (2013, Homo sapiens)
• Simplified scheme presenting multiple feedback loops in the EGFR pathway (2013, NA)
• Asparagine-linked glycosylation pathway (2013, NA)
• Four current models of PARP inhibitor-induced cancer cell killing (2013, NA)
• Regulation of autophagy by nutrient signals (2013, Homo sapiens)
• Key signaling pathways involved in genetic methylation of lymphoid malignancies (2013, NA)
• Signaling mechanisms proposed for the mammalian autophagy pathway (2013, NA)
• Regulation of hypoxia-inducible factor (HIF)–A expression or stabilization by pathways other than hypoxia (2013, NA)
• TNPA on insulin signaling pathways (2013, NA)
• Transcriptional and Gene Regulatory Network of Lactococcus lactis MG1363 during Growth in Milk (2013, Lactococcus lactis,Homo sapiens)
• Signaling pathway downstream of SOCE involved in turning off SOCE in endothelial cells (2013, Homo sapiens,Mus musculus)
• Proposal of how alliin could counteract the inflammatory state promoted by lipopolysaccharides (LPS) in 3T3-L1 adipocytes (2013, NA)
• Axon navigation pathway targeting by miRNAs that differentially associate with Ago2 in an activity-dependent manner (2013, NA)
• Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective (2013, NA)
• The BDNF signaling network (2013, NA)
• BMP2 signaling pathway resulting in osteogenesis or adipogenesis (2013, NA)
• New proposed model of BMP2-induced C2C12 cells differentiation (2013, NA)
• TGFB1 Smad signaling pathway contributes to HTS (2013, NA)
• Growth factor (doughnut) receptor engagement signals TOR activation through PI3K and MYC activation through the MEK-ERK pathway (2013, Homo sapiens)
• An illustration of the IIF pathway genes.Notes: Arrows indicate the direction of signal transduction (2013, Drosophila melanogaster,Caenorhabditis elegans,Venustaconcha ellipsiformis,Bombyx mori,Paracentrotus lividus,Anopheles gambiae,Ciona intestinalis,Strongylocentrotus purpuratus,Ecdysozoa,Gallus gallus,Danio rerio,teleost fish,Dipnomorpha,Xenopus tropicalis,Tetraodon nigroviridis,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Equus caballus,Monodelphis domestica,Homo sapiens,Mus musculus,Rattus norvegicus,Cavia porcellus,Pan troglodytes,Pongo pygmaeus,Saccharomyces cerevisiae,Arabidopsis thaliana)
• Interleukin-1B (IL-1B) stimulates SERT activity through an interleukin-1 receptor (IL-1R)- and p38 MAPK-dependent signaling pathway (2013, Mus musculus,Homo sapiens)
• Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• MDM2-p53 pathway revisited (2013, Lareunionomyces loeiensis,Panax ginseng,Homo sapiens,Mus musculus,Betapolyomavirus macacae,Bellapiscis medius)
• MDM2-p53 pathway revisited (2013, Lareunionomyces loeiensis,Panax ginseng,Homo sapiens,Mus musculus,Betapolyomavirus macacae,Bellapiscis medius)
• Capacity of Aptamers to Trigger Immune Activation in Human Blood (2013, NA)
• Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Campylobacter jejuni,Citrobacter rodentium,Mycobacterium avium,Clostridioides difficile CD3,Candidatus Sodalis pierantonius str. SOPE,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Aspergillus fumigatus,Coxsackievirus,Entamoeba histolytica,Derris trifoliata,unidentified virus,Homo sapiens,Canis lupus familiaris)
• CRH signaling pathway - This map represents the NetPath reactions of CRH signaling pathway (2013, NA)
• Rsu1 is a critical component for regulation of p38 Map kinase signaling from the IPP complex (2013, NA)
• Schematic diagram illustrating the different mechanisms by which P2 receptor subtypes might alter cancer cell function (2013, NA)
• When yeast cells meet, karyogamy! (2013, NA)
• Activation of Wnt/Beta-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients (2013, Armoracia rusticana,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance (2013, NA)
• NRAS mutant melanoma – undrugable? (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Structural and Logical Analysis of a Comprehensive Hedgehog Signaling Pathway to Identify Alternative Drug Targets for Glioma, Colon and Pancreatic Cancer (2013, NA)
• HOG signaling pathway in C (2013, Cryptococcus neoformans,Cryptococcus gattii VGI)
• Comprehensive Hedgehog Signaling Pathway (2013, NA)
• Kidney immune activation against ischemia-reperfusion and transplant injury (2013, Mus musculus,Homo sapiens)
• Type I interferon induction is inhibited by paramyxovirus interferon-antagonist proteins at multiple stages (2013, NA)
• High-Resolution Analysis and Functional Mapping of Cleavage Sites and Substrate Proteins of Furin in the Human Proteome (2013, NA)
• Integration of Canonical and Noncanonical Wnt Signaling Pathways Patterns the Neuroectoderm Along the Anterior–Posterior Axis of Sea Urchin Embryos (2013, Paracentrotus lividus,Tribolium castaneum,Branchiostoma lanceolatum,Strongylocentrotus purpuratus,Deuterostomia,Amphimedon queenslandica,Haliotis corrugata,Saccoglossus kowalevskii,Bos taurus,Oryctolagus cuniculus,Danio rerio,Xenopus laevis,Mus musculus,Armoracia rusticana,Homo sapiens)
• Ras, cAMP/PKA, and MSIL signaling pathways in C (2013, Cryptococcus neoformans,Cryptococcus gattii VGI)
• Model depicting the canonical Nrf2 stress response pathway in each of the different phases: basal, preinduction, induction, postinduction (2013, NA)
• Ca2+/calcineurin, Rim101, and Pkc1/Mpk1 MAPK signaling pathways in C (2013, Cryptococcus neoformans,Cryptococcus gattii VGI)
• Nucleotide excision repair (2013, NA)
• Energy metabolism in a typical mammalian cell (2013, Homo sapiens)
• Simplified network controlling the fate decisions between osteogenic and adipogenic lineages in huAFMSCs (2013, NA)
• Insulin signaling and glucose transport in normal hearts and in insulin resistance and type 2 diabetes (2013, Homo sapiens,Mus musculus)
• Insight into the role of CRMP2 (collapsin response mediator protein 2) in T lymphocyte migration (2013, NA)
• Laminin-211 in skeletal muscle function (2013, NA)
• PAR1b takes the stage in the morphogenetic and motogenetic activity of Helicobacter pylori CagA oncoprotein (2013, Helicobacter pylori)
• SLK signaling in apoptosis and cell cycle (2013, NA)
• Enhancement of Auranofin-Induced Apoptosis in MCF-7 Human Breast Cells by Selenocystine, a Synergistic Inhibitor of Thioredoxin Reductase (2013, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Sus scrofa,Homo sapiens,Armoracia rusticana)
• Whole genome and gene set enrichment analysis of cells expressing mutants of neuroserpin show an upregulation of the cholesterol pathway when polymers are expressed (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Cricetulus griseus,Homo sapiens,Drosophila melanogaster)
• Metabolic pathway of carbohydrate by anaerobic fungi (2013, NA)
• Wnt canonical pathway (2013, Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus,Dictyostelium discoideum)
• Osteoporosis – a current view of pharmacological prevention and treatment (2013, NA)
• Inhibitory pathway of PGE2 in effector T cells (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Murine leukemia virus,Hylobates sp.,Bos taurus)
• General overview of synthesis pathways for eicosanoids (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Murine leukemia virus,Hylobates sp.,Bos taurus)
• IGF signaling pathway (2013, Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Zea mays,Diaporthe sclerotioides,Xenopus laevis,Oreochromis niloticus,marmosets,Bacillus subtilis,Eriphia granulosa)
• Model depicting the refined Hippo pathway and step-wise LATS activation (2013, Mus musculus,Gallus gallus,Homo sapiens)
• VEGF and NOTCH signaling pathways (2013, Bos taurus,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Zea mays,Diaporthe sclerotioides,Xenopus laevis,Oreochromis niloticus,marmosets,Bacillus subtilis,Eriphia granulosa)
• Osteoporosis – a current view of pharmacological prevention and treatment (2013, NA)
• Toll-like receptor-4 signaling pathway (2013, Lactobacillus jensenii,Escherichia coli,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Bacillus subtilis At2,Streptococcus pyogenes,Lactiplantibacillus plantarum,Bacteroides fragilis,Lacticaseibacillus casei,Clostridium perfringens,Limosilactobacillus reuteri,Lactobacillus acidophilus,Bifidobacterium longum,Faecalibacterium prausnitzii,Salmonella enterica subsp. enterica serovar Typhi,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Bacteroides thetaiotaomicron,Lacticaseibacillus paracasei,Limosilactobacillus fermentum,Bifidobacterium breve,Bifidobacterium longum subsp. infantis,Lactobacillus gasseri,Ligilactobacillus salivarius,Bifidobacterium animalis,Lactobacillus acidophilus NCFM,Lactobacillus amylovorus,bacterium L,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,human metagenome,NA)
• Negative regulators of toll-like receptor-4 signaling pathway by Lactobacillus jensenii TL2937 in porcine intestinal epithelial cells and antigen presenting cells (2013, Lactobacillus jensenii,Escherichia coli,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Bacillus subtilis At2,Streptococcus pyogenes,Lactiplantibacillus plantarum,Bacteroides fragilis,Lacticaseibacillus casei,Clostridium perfringens,Limosilactobacillus reuteri,Lactobacillus acidophilus,Bifidobacterium longum,Faecalibacterium prausnitzii,Salmonella enterica subsp. enterica serovar Typhi,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Bacteroides thetaiotaomicron,Lacticaseibacillus paracasei,Limosilactobacillus fermentum,Bifidobacterium breve,Bifidobacterium longum subsp. infantis,Lactobacillus gasseri,Ligilactobacillus salivarius,Bifidobacterium animalis,Lactobacillus acidophilus NCFM,Lactobacillus amylovorus,bacterium L,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,human metagenome,NA)
• Main deregulated signaling pathways in PMBCL (2013, Homo sapiens)
• Proangiogenic mechanisms activated in the omentum during transcoelomic EOC metastasis in the presence of anti-VEGF therapy (2013, NA)
• Top network, “DNA Replication, Recombination, and Repair, Gene Expression, Cancer”, formed by genes exhibiting altered expression in MLT-pretreated MCF-7 cells upon MMS exposure relative to untreated MMS-exposed cells (2013, NA)
• Telomere maintenance pathway (2013, NA)
• Insulin/IGF-1 signaling pathway (2013, NA)
• Comparative analysis of seed transcriptomes of ambient ozone-fumigated 2 different rice cultivars (2013, NA)
• Comparative analysis of seed transcriptomes of ambient ozone-fumigated 2 different rice cultivars (2013, NA)
• Signaling networks involved in regulation of apoptosis in collecting duct cells (2013, NA)
• NPY signals through the GA subunit, while SST activates the GBG complex (2013, Mus musculus,Homo sapiens)
• Wnt pathway involved in the osteogenic and adipogenic differentiation of huAFMSCs (2013, NA)
• MicroRNA-182-5p targets a network of genes involved in DNA repair (2013, NA)
• Graphs showing the different regulation of glioma cell signaling when cells were cultured on biomatrix, myelin and unmyelinated tissue (retina) (2013, NA)
• Salicylic acid induces vanillin synthesis through the phospholipid signaling pathway in Capsicum chinense cell cultures (2013, NA)
• Schematic for the putative biosynthetic pathways of three major classes of active compounds in I (2013, NA)
• Statins Decrease Lung Inflammation in Mice by Upregulating Tetraspanin CD9 in Macrophages (2013, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Escherichia coli O55)
• Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosisEBV infection disrupts normal cell death and survival pathways in various human tumor cells, including lymphocytes, fibroblasts, and epithelial cells (2013, Homo sapiens,Human gammaherpesvirus 4)
• Presenilin functions (2013, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Physcomitrium patens,Homo sapiens,Mus musculus,Methanoculleus marisnigri JR1)
• Host Response to Respiratory Bacterial Pathogens as Identified by Integrated Analysis of Human Gene Expression Data (2013, NA)
• Schematic model of cell death mechanism in CACF-induced responses in melanoma A375 cells (2013, NA)
• Toll-like receptor (TLR) signaling pathway (2013, NA)
• Voltage-gated and SOCE co-exist in cardiomyocytes (2013, NA)
• All of animal cells may be intrinsically programmed to self-destruct (2013, NA)
• The arsenic induced liver damages and induction of gene expression through the Keap1-Nrf2-ARE signaling pathway (2013, Dipturus trachyderma,Clarias gariepinus,Channa punctata,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Psidium guajava)
• Inhibition of HCO3− absorption by lumen LPS in the MTAL (2013, NA)
• ROS in endoplasmic reticulum (ER) stress-induced cell death (2013, Homo sapiens)
• An overview of Cdc42 regulation during mating (2013, Saccharomyces cerevisiae,Homo sapiens)
• The potential role of miRNAs in the attenuated myogenic process in the elderly (2013, NA)
• Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury (2013, NA)
• Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury (2013, NA)
• Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury (2013, NA)
• The hypoxia inducible factor pathway (2013, Homo sapiens)
• Analysis of gene transcription in response to an acute bout of exercise identifies dysregulation of SMAD, CREB, and HDAC activity in LRT (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt/Beta-catenin signaling was activated in gemcitabine resistant NSCLC cell lines (2013, Homo sapiens,Candida dubliniensis)
• Extent to which glutamate (GLU) is oxidized in astrocytes seems to increase particularly during higher glutamate concentrations (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Involvement of the Notch pathway in terminal astrocytic differentiation: role of PKA (2013, NA)
• Notch signaling pathway – details in the text (2013, NA)
• Neurogenic and Neurotrophic Effects of BDNF Peptides in Mouse Hippocampal Primary Neuronal Cell Cultures (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus,Triportheus paranensis)
• AKT Signaling as a Novel Factor Associated with In Vitro Resistance of Human AML to Gemtuzumab Ozogamicin (2013, NA)
• DNA repair systems (2013, NA)
• NK cell activating and inhibitory receptors and their downstream signaling molecules (2013, NA)
• Evolution of the Eye Transcriptome under Constant Darkness in Sinocyclocheilus Cavefish (2013, NA)
• Putative miRNAs for the diagnosis of dyslexia, dyspraxia, and specific language impairment (2013, Homo sapiens)
• Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques (2013, Human immunodeficiency virus 1,Human alphaherpesvirus 2,Human adenovirus 5,Simian immunodeficiency virus,Simian immunodeficiency virus - agm,Simian immunodeficiency virus SIV-mnd 2,Homo sapiens,Macaca mulatta,Matthiola incana,Arachis hypogaea,Mus musculus,Schistosoma mansoni,Simian-Human immunodeficiency virus,Clinitrachus argentatus)
• Metabolism of glucoraphanin and glucobrassicin to biologically active metabolites (2013, NA)
• Toward understanding the genetics of regulatory T cells in ovarian cancer (2013, NA)
• Selected non-epigenetic effects of sulforaphane and I3C/DIM on prostate cancer cells (2013, NA)
• Nicotine-induced A7nAChR/JAK2 pathway in cooperation with nicotine-mediated ERK1/2 activation potentiates STAT3 activation in PC cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Different phosphorylation sites on STAT3 mediate canonical and non-canonical functions of the Notch signaling pathway (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Diagram of the WNT pathway (2013, herbal medicine)
• Indirubin is a potent inhibitor of GSK-3B, a key intermediate in the WNT pathway (2013, herbal medicine)
• TRB3 at the crossroads of ER stress and mTORC function (2013, Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• A signal transduction pathway for delayed-onset potentiation of the NMDA response by PregS (2013, Rattus norvegicus,Xenopus laevis,Homo sapiens)
• Upregulated HCV gene signature is enriched for interferon (IFN) pathway genes (2013, NA)
• PD-1 in T-cell activation, exhaustion, and effector function (2013, NA)
• A schematic representation of IL-12 family cytokines and the corresponding receptors and JAK-STAT signaling pathways (2013, NA)
• Ingenuity pathway analysis (IPA) of Interferon Signaling Pathway of genes differentially expressed in the bronchial epithelial cells exposed to Alternaria alternata spores (2013, Alternaria alternata,Homo sapiens)
• Myosin 1c in cellular signaling pathways (2013, NA)
• Intracellular signaling pathways activated by guidance cues (2013, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans,Corynebacterium phage gamma)
• Neural Stem Cell Death, Survival, and Differentiation in Response to Partial FGF-2 and EGF Deprivation (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Symphonia globulifera)
• Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes (2013, NA)
• Proposed model of OGG1 induction by DHF treatment and its cytoprotective effect against cell death (2013, Mus musculus,Saccharomyces cerevisiae,Armoracia rusticana,Cricetulus griseus,Cricetus cricetus,Ecklonia cava,Homo sapiens,Bos taurus,Escherichia coli)
• Pathway gene regulation of Cra (2013, Escherichia coli)
• Pathway regulation by CsrA (2013, Escherichia coli)
• Differentiation and commitment of IL-17-producing T helper (TH)17 cells in the midpoint of other coacting cells in favor of and against the harboring individual (2013, Staphylococcus aureus,Mycobacterium tuberculosis,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Klebsiella pneumoniae,Shigella flexneri,Francisella tularensis,Candidatus Arthromitus sp. SFB-mouse,Chlamydia muridarum,Mycobacterium sp.,Mycoplasmopsis bovis,Salmonella sp.,Mycoplasmopsis pulmonis,Chlamydia sp.,segmented filamentous bacterium,Saccharopolyspora rectivirgula,Candida albicans,Aspergillus fumigatus,Candida sp. uncertain placement,Candida albicans 23R,Gigaspora candida,Hepatitis B virus,Human alphaherpesvirus 1,Respiratory syncytial virus,Simian immunodeficiency virus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Toxoplasma gondii)
• MiRNAs involved in the regulation of the IGF-1/Akt pathway and myostatin signaling (2013, Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Oreochromis niloticus)
• Proposed mechanisms of the reduced activation of G3139 in RIT-INPs (2013, Mus musculus,Homo sapiens)
• Mechanism controlling adipogenesis and the physiology of adipose tissue (2013, Homo sapiens,Mus musculus)
• TGFB1 stimulated profibrotic epithelial signaling to pericytes during fibrotic kidney injury (2013, Mus musculus,Homo sapiens)
• PI3K-PTEN-Akt pathway (2013, Homo sapiens,Mus musculus)
• The roles of DcR3 in MFH tumor progression (2013, Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Known and Predicted Interactions between the Products of the 352 Genes Bound Preferentially by Pol II in Neuroepithelial CellsAnalysis was performed using STRING with a medium confidence score of 0.4 and all interaction methods available (2013, NA)
• A model for Src-induced tumorigenesis by JNK-dependent Hippo pathway regulation (2013, NA)
• Proposed schema of how the BMP signaling axis limits neurogenic muscle wasting (2013, NA)
• Poly-SNO-HSA as a safe and strong multiple antitumor agent (2013, NA)
• IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling (2013, NA)
• Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy (2013, NA)
• Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway (2013, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens)
• Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder – Possible Role for Methoxyindole Pathway (2013, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Homo sapiens)
• ERK Positive Feedback Regulates a Widespread Network of Tyrosine Phosphorylation Sites across Canonical T Cell Signaling and Actin Cytoskeletal Proteins in Jurkat T Cells (2013, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• RAS-mitogen-activated protein kinase signaling pathway (2013, NA)
• Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis)
• TLR signalling pathways: TLRs signal through myeloid differentiation primary response gene 88 (MyD88) or/and TIR-domain-containing adapter-inducing interferonB (TRIF)-dependent pathways (2013, NA)
• Proposed pathway of CD33 siglec-mediated suppression of cellular function in Leishmania infection (2013, NA)
• Cytoscape plugin was used to analyse within C57Bl/6 up-regulated genes, genes interaction within the same pathway and across different pathways (2013, NA)
• Mechanism of repression of neurogenic bHLH transcription factors by BMPs (2013, NA)
• Signaling via by cytokines and growth factors and its negative regulation by SOCS proteins (2013, NA)
• DR4 and DR5 Agonistic mAb-induced Apoptosis: Regulation of TRAIL/Apo2L Resistance by HDACi (2013, NA)
• WWOX/WOX1 and signaling networks (2013, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Homo sapiens)
• Simplified schematic shows the major intracellular signal transduction pathways that regulate the epithelial-to-mesenchymal transition (EMT) process in fibrotic kidneys (2013, Homo sapiens)
• Pathway representation of canonical and Pyk2-mediated TLR9 signaling (2013, NA)
• GXM-mediated inhibition of LPS-induced signal (2013, NA)
• Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology (2013, NA)
• Normal signaling pathways and alterations in aged DCs in response to lipopolysaccharide (LPS)/bacteria (A), and in response to self antigen (DNA) (2013, Homo sapiens)
• Self-renewal pathway: Wnt/Beta-Catenin (2013, NA)
• Regulation of RB/E2F pathway (2013, NA)
• Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology (2013, NA)
• Coordinated action of glial and neuronal purinergic receptors and purines in the CNS (2013, NA)
• The role of chemotherapy and latest emerging target therapies in anaplastic thyroid cancer (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanism underlying GD T cell killing of tumours: GD T cell receptor (TCR) interacts with isopentenyl pyrophosphate (IPP) generated through the mevalonate pathway in tumours (2013, NA)
• Tumor repopulation during cancer radiotherapy (2013, Homo sapiens,Mus musculus,Dipturus trachyderma)
• Iron transport across the placenta (syncytiotrophoblasts) (2013, NA)
• Iron homeostasis in absorptive enterocytes, macrophages, erythroblasts, and hepatocytes and its routes of circulation in the organism (2013, NA)
• JAK2-STAT5B pathway and osteoblast differentiation (2013, Homo sapiens,Mus musculus)
• HER-2 structure, activation, and signalling (2013, NA)
• Canonical pathway representing NRF2-mediated oxidative stress response obtained by IPA from the analysis of SW480 data set (2013, Homo sapiens,Salvia rosmarinus)
• Activation of Hedgehog signaling pathway in mouse uterus in estrus versus proestrus (2013, NA)
• Activation of the Wnt signaling pathway in mouse uterus in estrus versus proestrus (2013, NA)
• Canonical pathway representing LPS/IL-1-mediated inhibition of RXR function obtained by IPA from the analysis of HT29 data set (2013, Homo sapiens,Salvia rosmarinus)
• MiR-146b function in IEC-6 cells mediating TGFB signaling (2013, NA)
• Possible pathways for growth factor mediated tumorigenesis (2013, Homo sapiens,Mus musculus,unidentified,NA)
• Schematic diagram illustrating the main signaling pathways responsible for kisspeptin-induced depolarization and burst firing of GnRH neurons (2013, Mus musculus,Homo sapiens)
• TRAF2 signal pathway networks (2013, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Homo sapiens)
• Signaling pathways showing mechanisms involved in the protective effects of cardiac-specific CYP2J2 transgenic mice subjected to diabetic stress (2013, NA)
• Regulation of prosurvival and apoptotic pathways by ER stress (2013, NA)
• Action of Smac mimetics.Notes: IAPs are important regulators of NFKB-activating signaling pathways (2013, Homo sapiens)
• Autophagy and selective deployment of Atg proteins in antiviral defense (2013, NA)
• Association between Inflammatory Infiltrates and Isolated Monosomy 22/del(22q) in Meningiomas (2013, NA)
• JAK2-STAT5B pathway and osteoblast differentiation (2013, Homo sapiens,Mus musculus)
• Signaling pathways in RILF (2013, NA)
• Key signaling cascades in HCC (2013, Homo sapiens,Mus musculus,Hepatitis B virus,Vicia sativa,NA)
• An example pathway for the induction of the ubiquitin proteasome pathway (2013, NA)
• Cell cycle checkpoint pathway activated by DNA damage (2013, Homo sapiens,Mus musculus)
• SIRT1-dependent deacetylation of substrate proteins (2013, NA)
• The role of SQ22,536 in cAMP signaling (2013, NA)
• Nicotine’s effect on multiple signal transducers in the downstream pathway of calcium (2013, NA)
• Genes whose mRNA expression is suppressed by nicotine in RAW264.7 cells under poly(I:C) stimulation compared with those under poly(I:C) stimulation only are mapped to three gene networks, as predicted by ingenuity pathway analysis (IPA) (2013, NA)
• Intracellular mechanisms underlying Wnt-induced axon guidance (2013, NA)
• Axon growth by purinergic receptors (2013, NA)
• Calcium and calcium-permeable channels in the control of autophagy (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Dictyostelium discoideum,Homo sapiens,Cleyera japonica)
• Somatic variations in genes encoding proteins of the KEGG “Melanoma” signaling pathway (2013, NA)
• RLR-mediated pathways of type I interferon and inflammatory responses (2013, NA)
• SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation (2013, Homo sapiens)
• Calcium cycling proteins and heart failure: mechanisms and therapeutics (2013, NA)
• Calcium cycling proteins and heart failure: mechanisms and therapeutics (2013, NA)
• Wnt signaling pathways (2013, NA)
• Interplay of TLR and RLR signaling (2013, NA)
• Metabolism of cancer cells is regulated by signaling pathways related to oncogenes and tumor-suppressor genes (2013, NA)
• Schematic illustrating a model of NA anticancer activity is proposed (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Agaricus bisporus,Saccharomyces cerevisiae VR1,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,NA,NA)
• CVB3-induced the PI3K-Akt-mTOR-apoptosis signaling pathway (2013, Coxsackievirus B3,Homo sapiens)
• Bcl-2 family-regulated pathway and phenotypes in Bcl-2 knockout mice after status epilepticus (2013, NA)
• Mechanism for epithelial–mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3) (2013, NA)
• Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells (2013, Mus musculus,Adenoviridae,Cricetus cricetus,Mesocricetus auratus,Human adenovirus 5,Human adenovirus sp.,Homo sapiens,Bos taurus)
• (A–C) Schematic overview of particle-based vaccines (2013, NA)
• Schematic diagram showing the involvement of CPT1C and ceramides in the hypothalamic ghrelin signaling pathway (2013, NA)
• Analysis strategy (–) to identify the putative regulatory effect of GWAS candidate () on FRMD3 regulation (), linking the gene to transcriptional regulation of the BMP pathway (–) and DN and suggesting a hypothetical regulatory model () (2013, Mus musculus,Rattus norvegicus,Zea mays,Sequoia sempervirens,Homo sapiens,Acanthamoeba polyphaga mimivirus)
• Human pre-BCR-induced signal transduction depicted from the current study (2013, NA)
• Activation of the IRS signaling cascade pathways (2013, NA)
• Interferon Signaling Pathway identified by Ingenuity software (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Molecular network generated by Ingenuity Pathway Analysis (IPA) of highly significant gene changes in human RPE cells after in vitro stimulation with AGE (10 μg/mL) (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Proposed schematic depicting the different outcomes of NHEJ factors in Beta-cells after DNA damage (2013, NA)
• Pulmonary vasodilation is a synchronized process (2013, Ovis aries,Homo sapiens)
• Pulmonary vasoconstriction is orchestrated (2013, Ovis aries,Homo sapiens)
• Pathways impinging specifically on glucose-mediated F-actin remodeling in the B cell (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Aphyosemion alpha,Thomasclavelia spiroformis)
• Hypothetical representation of opposite downstream effects of two signaling pathways on the G1 phase of the cell cycle in a breast tumor-initiating cell (2013, NA)
• Subnetwork representation of protein interactions based on 78 mutated genes in 602 breast cancers - (2013, NA)
• The insulin-signaling pathway (2013, NA)
• Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) hippocampus (Hp) (2013, Mus musculus,Rattus norvegicus,Symphonia globulifera,Gastrodia elata,Homo sapiens,prion,Microbacterium aurantiacum,Buteo buteo insularum)
• Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) parietal cortex (pCx) (2013, Mus musculus,Rattus norvegicus,Symphonia globulifera,Gastrodia elata,Homo sapiens,prion,Microbacterium aurantiacum,Buteo buteo insularum)
• Shh and Wnts guide commissural axons in the vertebrate spinal cord (2013, NA)
• Ingenuity Pathway Analysis (IPA)-generated network of isobaric tag for relative and absolute quantitation (iTRAQ)-identified proteins and their interacting partners in Alzheimer's disease (AD) cerebellum (Cb) (2013, Mus musculus,Rattus norvegicus,Symphonia globulifera,Gastrodia elata,Homo sapiens,prion,Microbacterium aurantiacum,Buteo buteo insularum)
• Gene Regulatory Network for cenH3 Deposition in Arabidopsis and Coexpression of KNL2 and cenH3 with Genes of the RBR-E2F Transcription Regulation Pathway and with DNA and H3 Methyltransferases.(A) Key regulator genes are indicated by yellow octagons (2013, NA)
• Network exploration options (2013, NA)
• Network links between 23 genes in pathway of mismatch repair and three driver genes (2013, NA)
• Schematic diagram of Apicomplexa illustrating the differences in the metabolic capabilities of T (2013, Plasmodium falciparum,Toxoplasma gondii,Plasmodium vivax,Cryptosporidium parvum,Neospora caninum,Eimeria tenella,Theileria parva,Theileria annulata,Cryptosporidium hominis,Toxoplasma gondii ME49,Cryptosporidium muris,Babesia bovis,Homo sapiens,Bos taurus,Escherichia coli)
• Brain site-specific proteome changes in aging-related dementia (2013, Mus musculus,Rattus norvegicus,Symphonia globulifera,Gastrodia elata,Homo sapiens,prion,Microbacterium aurantiacum,Buteo buteo insularum)
• Signaling pathways and transcription factors supporting or affecting the barrier phenotype of CNS-ECs (2013, Mus musculus,Rattus norvegicus,Bos taurus,Danio rerio,Human immunodeficiency virus 1,Ovis aries,Human gammaherpesvirus 4,Moolgarda engeli,Homo sapiens,Drosophila melanogaster)
• TAM receptor signaling pathways (2013, Homo sapiens)
• Model of the signaling pathway regulating ICAP-1A function in the dynamics of B1 integrin-mediated FAs (2013, NA)
• Schematic drawing of developmental switch in neurotrophin dependence (2013, NA)
• TRAIL signalling induces the extrinsic apoptotic pathway (2013, NA)
• Hypothesis for the development of tactile allodynia following nerve injury (2013, NA)
• Potential role of the receptor for advanced glycation end-products (RAGE)-ligand system in the pathophysiology of aortic aneurysms (2013, NA)
• Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens (2013, Rift Valley fever virus,Human immunodeficiency virus 1,Dengue virus,Human betaherpesvirus 5,Measles morbillivirus,Betapolyomavirus macacae,Mycobacterium tuberculosis,Chlamydia trachomatis,Francisella tularensis,Leishmania major,Leishmania donovani,Homo sapiens,Mus musculus,NA)
• Missing Link between Itch and Inflammation in Atopic Dermatitis (2013, NA)
• In Utero Exposure to Second-Hand Smoke Aggravates the Response to Ovalbumin in Adult Mice (2013, Mus musculus,Homo sapiens)
• TAM-regulated cycle of inflammation in dendritic cells (2013, Homo sapiens)
• BMP2-WNT4-FOXO1 pathway in HESC differentiation (2013, NA)
• Concept map of Whi5 function (2013, NA)
• Glutamate receptor activation on APP processing (2013, NA)
• Enrichment of the Notch signaling pathway in glioma CSCs (2013, Mus musculus,Homo sapiens)
• Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling (2013, NA)
• Model depicting mitochondrial generation of H2O2 as a key modulator of TCR-mediated signal transduction (2013, NA)
• Targetable metabolic actors by natural compounds (2013, Saccharomyces cerevisiae,Olea europaea,Curcuma longa,Camellia sinensis,Zingiber officinale,Salvia rosmarinus,Hibiscus sabdariffa,Annona muricata,Cephalosporium caerulens,Saururus cernuus,Hymenocallis littoralis,Alkanna tinctoria,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Oncogenic role of the AKT signaling pathway (2013, Dipturus trachyderma,Calloplesiops altivelis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Signaling through NLR receptors in lupus (2013, NA)
• p53-induced cell cycle control and apoptosis (2013, Dipturus trachyderma,Calloplesiops altivelis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Biosynthesis pathway of the FAs in plants (2013, NA)
• ErbB-2 signaling and androgen sensitivity regulated by cPAcP in prostate cancer cells (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Pan troglodytes)
• Transforming growth factor B (TGFB) signaling pathway in hypothermia (2013, Homo sapiens,Mus musculus)
• The interactions between the control of the cell cycle and the expression of specific ligands for activating NK receptors in various pathologies (2013, NA)
• Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells (2013, NA)
• Meta-Analysis Identifies NFKB as a Therapeutic Target in Renal Cancer (2013, NA)
• Function and regulation of AMPK leading to tumor suppression (2013, NA)
• The role of Wnt7a-induced hsa-miR29b expression in NSCLC proliferation (2013, Drosophila melanogaster,Caenorhabditis elegans,Matthiola incana,Bikinia letestui,Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis,vectors)
• Energy status of cells modulating cell signaling and mitochondrial function (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Paracentrotus lividus)
• Interplay between p53 and AKT/mTOR in regulating autophagy (2013, Dipturus trachyderma,Calloplesiops altivelis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Regulation of STATs by polycystin-1 and their role in polycystic kidney disease (2013, NA)
• Separate PI3K and Wnt signaling pathways (2013, NA)
• EGFR and JAK-STAT signaling (2013, NA)
• Working model of chronic morphine-induced adaptations in ventral tegmental area (VTA) dopamine neurons (2013, NA)
• Schematic overview of the VEGF pathway (2013, NA)
• Synthetic circuits based on the rewired cell-signaling pathways (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Embryophyta,Aspergillus nidulans,Neurospora crassa,Aspergillus flavus,Lepidium sativum,Escherichia coli,Vibrio cholerae,Chlamydia trachomatis,Deinococcus radiodurans,Gallus gallus,synthetic gene,synthetic RNA,Vipera berus,Homo sapiens,Mus musculus,Bos taurus)
• HIV-1 Vpr Modulates Macrophage Metabolic Pathways: A SILAC-Based Quantitative Analysis (2013, NA)
• BIOBASE-derived signaling network centered on p38 MAPK (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Sequoia sempervirens,Stenocypris major)
• Resistance to vemurafenib (2013, NA)
• Proposed signaling pathway of this study (2013, Homo sapiens,Mus musculus,Bos taurus,Dipturus trachyderma)
• Prolyl isomerization (2013, NA)
• Regulation of lysosome biogenesis and functions in osteoclasts (2013, Homo sapiens)
• Induction of migratory heterogeneity during priming (2013, NA)
• Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis (2013, Homo sapiens,Helicobacter pylori)
• Summary of the interactions identified in this work between Dmrt5 and the secreted ligands and Wnt/Bmp regulated graded transcription factors expressed during early patterning of the cerebral cortex (2013, NA)
• Main signaling pathways activated by cannabinoid receptors (2013, Oryza sativa,Diaporthe sclerotioides,Cannabis sativa,Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Hypothetical outcomes for demyelinated axon.Denuded axon impermissive for myelination (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Gallus gallus,Triportheus paranensis,Homo sapiens,Diaporthe sclerotioides,Theilers encephalomyelitis virus)
• Sphingolipid involvement in ethanol-induced apoptosis in the P7 mouse brain (2013, NA)
• UV-induced cyclobutane dimers- structure (A) and repair by the Nucleotide Excision DNA Repair (NER) pathway (B) (2013, Homo sapiens,Mus musculus,Dipturus trachyderma)
• Extrinsic and intrinsic pathways of apoptosis (2013, Homo sapiens,Mus musculus)
• Nucleotide excision repair (NER) pathway (2013, Homo sapiens,unidentified shuttle vector)
• Glucose (C-source) availability regulates cell growth through multiple signaling pathwaysDuring glucose starvation, decreasing production of cellular energy leads to the activation of AMP-activated kinase (AMPK, yeast Snf1) (2013, NA)
• Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling (2013, Bos taurus,Capra hircus,Equus asinus,Coxsackievirus,Hepatovirus A,Homo sapiens,Mus musculus,Armoracia rusticana)
• Illustration of important relationships between metabolome, proteome, and genome in cancerous cells (2013, NA)
• Schematic overview of the PDGF pathway (2013, NA)
• Oral Neutrophil Transcriptome Changes Result in a Pro-Survival Phenotype in Periodontal Diseases (2013, NA)
• HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes (2013, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Human adenovirus 2,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Drosophila melanogaster,Cricetulus griseus,Dictyostelium discoideum,Homo sapiens,Armoracia rusticana)
• Predictive metabolic pathway of biosynthesis in M (2013, Medicago truncatula)
• Toll-like receptor signaling pathway: recognition of pathogens through TLR ultimately triggers signaling through the NFKB pathway, consequently leading to gene activation and production of pro-inflammatory cytokines/chemokines (2013, NA)
• Canonical signaling of muscarinic receptors (2013, NA)
• Role of oxysterols in regulating cell signaling pathways related to oxidative reactions (2013, Homo sapiens)
• Mutational Landscape of Adenoid Cystic Carcinoma (2013, NA)
• ‘ErbB signalling' and ‘TGFB pathway' in the canonical pathway (2013, Homo sapiens,Mus musculus,Bos taurus)
• Cocaine causes transcription-dependent neuroplasticity in the reward pathway (2013, NA)
• Representative anti-angiogenic drugs and their targets in the angiogenic pathway (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways that relate disturbed polycystin-mediated Ca2+signaling to cell proliferation (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Canis lupus familiaris,Xenopus laevis)
• Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Campylobacter jejuni,Citrobacter rodentium,Mycobacterium avium,Clostridioides difficile CD3,Candidatus Sodalis pierantonius str. SOPE,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Aspergillus fumigatus,Coxsackievirus,Entamoeba histolytica,Derris trifoliata,unidentified virus,Homo sapiens,Canis lupus familiaris)
• Molecular background of major signaling pathways responsible for proper development of muscles and muscle stem cells in normal tissues and tissues affected by laminopathy (2013, NA)
• Enrichment of hyper- and hypophosphorylated peptides in the ERK/MAPK signaling pathway in the phosphoproteome of murine liver on treatment with high-fat versus low-fat diet (2013, Mus musculus,Homo sapiens)
• FGF signaling pathway (2013, NA)
• Diagram showing the model proposed for the association of EMT, CSCs and the PI3K/Akt/mTOR signaling pathway in CaP radioresistance and the effect of possible action of BEZ235 on radiosensitivity (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Oncogenic and tumor suppressive autophagic pathways involved in miRNAs (2013, NA)
• Altered Protein Networks and Cellular Pathways in Severe West Nile Disease in Mice (2013, Hepatitis B virus,unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Vesicular stomatitis virus,West Nile virus,Japanese encephalitis virus,Ebola virus sp.,Classical swine fever virus,African swine fever virus,Kunjin virus,mosquito-borne viruses,West Nile virus strain NY-99,Grapevine virus A,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Osphranter robustus,Homo sapiens,Pan troglodytes,Chlorocebus aethiops,Mus musculus,Rattus norvegicus,Plasmodium falciparum,Aedes aegypti,NA,NA,NA,NA)
• NGF-Induced Cell Differentiation and Gene Activation Is Mediated by Integrative Nuclear FGFR1 Signaling (INFS) (2013, NA)
• Proposed model of p38 MAPK regulation of mRNA translation (2013, NA)
• Proposed interaction of AMPK on insulin signaling and GLUT4 translocation (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Venustaconcha ellipsiformis)
• Ang signaling pathway (2013, NA)
• Serine, one-carbon cycle, glycine synthesis (SOG) pathway (2013, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Oryctolagus cuniculus)
• Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Campylobacter jejuni,Citrobacter rodentium,Mycobacterium avium,Clostridioides difficile CD3,Candidatus Sodalis pierantonius str. SOPE,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Aspergillus fumigatus,Coxsackievirus,Entamoeba histolytica,Derris trifoliata,unidentified virus,Homo sapiens,Canis lupus familiaris)
• Dynamic CREB family activity drives segmentation and posterior polarity specification in mammalian somitogenesis (2013, Homo sapiens,Mus musculus)
• IGF-1R Signaling Pathway (2013, NA)
• Synergy between TCR/CD28 and TNFR signalosomes for activation of the PI3K-Akt pathway in T cells (2013, Homo sapiens,Mus musculus,Human immunodeficiency virus,NA)
• Tumor necrosis factor receptor family molecules that possibly activate the PI3K-Akt pathway in T cells (2013, Homo sapiens,Mus musculus,Human immunodeficiency virus,NA)
• Ligand stimulation of ERK and PI3K signaling in BRAFV600E melanomas (2013, NA)
• RAS-RAF-MEK-ERK signalling pathway (2013, NA)
• Regulation of Th9-Type Pulmonary Immune Responses. A New Role for COX-2 (2013, NA)
• Immunological synapse: the gateway to the HIV reservoir (2013, Human immunodeficiency virus 1,Hepatitis B virus,Human immunodeficiency virus,Human T-cell leukemia virus type I,Murine leukemia virus,Homo sapiens,Lareunionomyces loeiensis,Macaca mulatta,Lavandula angustifolia,Mus musculus,NA)
• Molecular mechanism for Elovl5 control of mTORC2, FoxO1-S256 phosphorylation, and hepatic GNG (2013, Mus musculus,Homo sapiens)
• Generalized overview of the regulation of apoptosis by sphingolipids (2013, NA)
• The Effect of Curcumin on Breast Cancer Cells (2013, Homo sapiens,Mus musculus,Curcuma longa)
• PRL-Dependent Tyrosyl Phosphorylated PAK1 and 3D Collagen IV Regulate MMP-1 and MMP-3 Production and Invasion via MAPK Pathways Schematic representation of the proposed working model (2013, NA)
• DMGs in the KEGG 'Toll-like receptor signaling' pathway (2013, NA)
• Proposed mechanism demonstrating the interplay of heme oxygenase 1 (HO-1) and the Wnt canonical pathway in the modulation of adipogenesis in mesenchymal stem cells (MSC)-derived adipocytes (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis)
• Wnt signaling pathway in diabetes mellitus (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• MiRNAs implicated in neurodegeneration (2013, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Molva molva,Morchella esculenta)
• Metabolic map of virus-encoded carbon metabolism host genes from 12 viromes in sunlit Pacific Ocean waters (2013, NA)
• Gene sets are not pathways (2013, Homo sapiens,vectors)
• Signaling pathways involved in EndoMT (2013, NA)
• Intersection of BC modules 143, 79 and 82 (2013, Hepatitis B virus,Human T-cell leukemia virus type I,Homo sapiens,Saccharomyces cerevisiae,Helicobacter pylori)
• Xenogeneic-Free Protocol for Isolation and Expansion of Human Adipose Stem Cells for Clinical Uses (2013, Homo sapiens,Mus musculus,Bos taurus,prion,Schizosaccharomyces pombe,Hathewaya histolytica)
• Lin28/let-7 regulatory axis (2013, Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Bacillus subtilis,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Diaporthe sclerotioides,Xenopus tropicalis)
• GenMAPP schematic of cell cycle pathway genes (2013, NA)
• Cell Survival Signalling through PPARD and Arachidonic Acid Metabolites in Neuroblastoma (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Schematic presentation of the molecular mechanisms of myogenic differentiation (2013, NA)
• Core genes for cetuximab and PX‐866 susceptibility (2013, Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,Alphapapillomavirus 7,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Distinctive Profile of IsomiR Expression and Novel MicroRNAs in Rat Heart Left Ventricle (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Drosophila melanogaster,vectors)
• Schematic diagram that describes neuroprotective effects of SUL against ABeta-induced oxidative cell death in AD (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Brassica oleracea)
• Influence of glycans and glycan-binding proteins in death receptor signaling and function (2013, NA)
• Common signaling pathway for Toll/IL-1R (TIR) family members (2013, NA)
• TIR8/SIGIRR, a negative regulatory receptor of ILR and TLR signaling (2013, Gallus gallus,Danio rerio,teleost fish,Salmo salar,Escherichia coli,Mycobacterium tuberculosis SP1,Lactobacillus jensenii,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Major catabolic and anabolic pathways in mammalian cells (2013, NA)
• Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity (2013, Mus musculus,Rattus norvegicus,Armoracia rusticana,Phleum pratense,Homo sapiens,Escherichia coli,Oryctolagus cuniculus,Gallus gallus)
• Roles of molecules explained in this review in signal transduction (2013, NA)
• SMAD/BMP pathway in hepatocytes (2013, NA)
• Transcriptional activation of antioxidant and aflatoxin biosynthetic genes by oxidative stress-related transcription factors (2013, NA)
• Model showing proposed molecular steps of the Pep immune signal transduction pathway (2013, Arabidopsis thaliana,Pseudomonas syringae)
• Proposed mechanisms for ziyuglycoside II induced cell cycle arrest and apoptosis in MDA-MB-435 cells (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,herbal medicine,Vasconcellea candicans,Sanguisorba officinalis,Homo sapiens,Haemonchus contortus)
• Proposed mechanisms of FGFRL1-directed signaling via SHP-1 (2013, NA)
• NFKB activation pathway is regulated by S-nitrosylation (2013, NA)
• Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Vibrio cholerae,Bacillus anthracis,Escherichia coli BL21,Citrobacter rodentium,Legionella pneumophila,Yersinia pseudotuberculosis,Yersinia pestis KIM10,Legionella pneumophila serogroup 1,Mus musculus,Rattus norvegicus,Cricetulus migratorius,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus)
• Schematic presentation of select miRNAs that regulate toll-like receptor signaling pathways (2013, NA)
• Proposed mechanism for the CD8+-cell-mediated suppression of HIV-1 replication (2013, NA)
• DC restriction and type I IFN response (2013, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Vesicular stomatitis virus,West Nile virus,Measles morbillivirus,Human immunodeficiency virus 2,Influenza A virus H3N2,Homo sapiens,Mus musculus)
• Interaction between quality control systems for ER protein folding and RNA biogenesis (2013, Homo sapiens,Caenorhabditis elegans)
• Function of significant modules and nodes of genetic sub-network in the brain of SAMP8 mice (2013, Diaporthe sclerotioides,Ginkgo biloba,Melia azedarach,Mus musculus,Rattus norvegicus,Homo sapiens)
• Two TLR signaling pathways (2013, NA)
• Pathway Studio analysis of the differentially expressed proteins of extremely severe HFMD serum samples. Proteins identified in Table  were imported into PathwayAssist and an interaction map was created (2013, Hepatitis B virus,Enterovirus A71,Coxsackievirus A16,Enterovirus A,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• EZH2 takes the stage when BRCA1 loses (2013, Homo sapiens,Mus musculus)
• Renin-angiotensin-aldosterone system and regulation of insulin signaling phosphorylation of docking protein insulin receptor substrate -1 (IRS-1) is the major converging point in insulin signaling (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• The action of PML on metabolism (2013, NA)
• Main metabolic pathways implicated in energy production in astrocytes with a prominent role for glycolysis (2013, NA)
• D1 receptor-mediated ERK activation signaling pathway (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Natronomonas pharaonis)
• D2 receptor-mediated ERK activation signaling pathway (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Natronomonas pharaonis)
• Schematic presentation of the influence of angiogenesis inhibitors on EC signaling (2013, NA)
• Tumor (SVZ) micro-environment (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Human betaherpesvirus 5)
• Connectivity map of NRF2-mediated oxidative stress response adapted from IPA software (2013, NA)
• Schematic model of adaptive primary resistant responses by tumors to anti–IGF-1R monoclonal antibodies (mAbs) (2013, Homo sapiens,Mus musculus)
• Cellular mechanisms of BBR in reverting dysfunction in NAFLD (2013, Saccharomyces cerevisiae,Oryza sativa,herbal medicine,Curcuma longa,Berberis vulgaris,Hydrastis canadensis,Berberis aristata,Berberis aquifolium,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli SCD1)
• The possible signaling pathways regulated by YMGKI-1, through which to inhibit the EMT, stemness properties, and tumorigenicity of head and neck cancer initiating cells (HN-CICs) (2013, Diaporthe sclerotioides,Agaricus bisporus,Momordica charantia,Ganoderma microsporum,Homo sapiens,Mus musculus,NA)
• Network view of TGF-beta signaling pathway alterations in colorectal and ovarian cancer (2013, NA)
• Genome-wide RNAi Screen Reveals a New Role of a WNT/CTNNB1 Signaling Pathway as Negative Regulator of Virus-induced Innate Immune Responses (2013, NA)
• Reprogramming Neutral Lipid Metabolism in Mouse Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes (2013, Leishmania amazonensis,Homo sapiens)
• Choline Plasmalogens Isolated from Swine Liver Inhibit Hepatoma Cell Proliferation Associated with Caveolin-1/Akt Signaling (2013, NA)
• IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis (2013, NA)
• Nrx in Wnt/Dvl and Toll-like receptor 4 (TLR4) signaling (2013, Homo sapiens)
• Models of Eph signaling in amphid axon guidance (2013, NA)
• KEGG pathway analysis (2013, NA)
• Important pathways in HCC Shown is the mTOR/AKP/PIP3 pathway that contributes to transformation of nodules into metastatic counterparts (2013, NA)
• iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies (2013, NA)
• Schematic showing the mechanism‐based strategies and relationship between mitochondrial reactive oxygen species (ROS) and biochemical dysfunction (2013, NA)
• Proposed mechanism underlying disrupted brain insulin signaling in Alzheimer's disease (AD) (2013, Homo sapiens,Mus musculus)
• Diagram of hedgehog (Hh) signaling in mammalian cells (2013, NA)
• Application of the algorithm to identify TNBC-associated genes (2013, NA)
• An Integrated Approach Based on Multiplexed Protein Array and iTRAQ Labeling for In-Depth Identification of Pathways Associated to IVF Outcome (2013, NA)
• Cytokine intracellular signaling pathways (2013, Homo sapiens)
• Intrinsic and extrinsic apoptosis signaling pathways (adapted from ref (2013, NA)
• Classification of Toll-like receptors (TLRs) (2013, Homo sapiens)
• Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway (2013, NA)
• RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation (2013, Diaporthe sclerotioides,Helianthus annuus,Cladophora subtilissima,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli,gut metagenome,S2-like reptarenavirus)
• Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells (2013, Homo sapiens,Mus musculus)
• Cell Survival Following Radiation Exposure Requires miR-525-3p Mediated Suppression of ARRB1 and TXN1 (2013, NA)
• RNA Sequencing of the Human Milk Fat Layer Transcriptome Reveals Distinct Gene Expression Profiles at Three Stages of Lactation (2013, Diaporthe sclerotioides,Helianthus annuus,Cladophora subtilissima,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli,gut metagenome,S2-like reptarenavirus)
• WNT signaling pathway (2013, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,vectors)
• Schematic diagram summarizing available information obtained using animal models to investigate the role of TGFB signaling in wound healing (2013, Mus musculus,Homo sapiens)
• GC-C-dependent signaling pathway of guanylin peptides in the intestine (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Cavia fulgida,Oryctolagus cuniculus,Sus scrofa,Macropus sp.,Homo sapiens,Escherichia coli,Dipnomorpha,Non-A non-B hepatitis virus,Coloceras guinea)
• Hypothetic assembly of a PKA microdomain beneath the NMJ (2013, NA)
• Schematic model of signaling pathways in salinomycin-induced cell growth inhibition and apoptosis (2013, NA)
• Proposed model of miR-129 function as a potential tumor suppressor in CRC and a sensitizer to 5-FU-based chemotherapy (2013, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Gallus gallus,Armoracia rusticana,clinical samples)
• Schematic diagram illustrating miR-185 and ATR function in radiation response (2013, NA)
• Non-immune mechanisms of muscle damage and weakness (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Candida dubliniensis)
• New model for phrenic long-term facilitation with multiple signaling pathways (2013, Mus musculus,Rattus norvegicus,Gallus gallus,Anas platyrhynchos,Homo sapiens,Felis catus)
• The relationships between the RA, FGF and Notch pathway in Xenopus PSM (2013, NA)
• The JAK/STAT and Hh pathways (2013, Homo sapiens,Drosophila melanogaster)
• Major signaling pathways regulating RSV-induced NFKB and IRF activation in airway epithelial cells (2013, NA)
• Innate immune mechanisms of muscle damage in myositis (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Candida dubliniensis)
• Pathways involved in stem cell hemostasis via regulation of nutrient sensing (2013, NA)
• Tie2 (to) Abl (2013, NA)
• Immune responses of macrophages and dendritic cells regulated by mTOR signaling (2013, Mycobacterium tuberculosis,Listeria monocytogenes,Porphyromonas gingivalis,Homo sapiens,Mus musculus,Nicotiana tabacum,Human immunodeficiency virus 1,Leishmania donovani)
• Wnt signaling pathway in the primary cilia (2013, NA)
• Schematic representation showing the proposed mechanism (2013, Homo sapiens,Mus musculus)
• An example of a KEGG pathway containing genes involved in multiple processes (2013, Homo sapiens)
• Apoptosis signaling pathway (2013, NA)
• Failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• Crosstalk of the canonical NFKB pathway with other signaling processes (2013, NA)
• STAT2 and IRF9 (2013, NA)
• Scheme depicting the interactive roles of interferon, Trim, and Socs molecules regulating the innate response in SjS-susceptible C57BL/6.NOD-Aec1Aec2 mice (2013, Homo sapiens,Mus musculus,dsRNA viruses,Euonymus japonicus)
• IL-17 signaling and A20 (2013, NA)
• p53 regulated developmental pathways (2013, NA)
• Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells (2013, NA)
• Regulation of autophagy by oncogenes and tumor suppressors (2013, Homo sapiens)
• Proteomic Profiling of Rabbit Embryonic Stem Cells Derived from Parthenotes and Fertilized Embryos (2013, NA)
• Sleep specific effects on protein processing and the unfolded protein response (2013, NA)
• The valine degradation pathway from the differentially regulated genes in response to 3–7 days of mechanical overload (2013, Mus musculus,Homo sapiens)
• Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes (2013, NA)
• Wnt signalling pathways implicated in diabetic nephropathy (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Two MAPK pathways promoting axon regeneration in Caenorhabditis elegans (2013, Homo sapiens)
• The ILK signaling and its putative regulation by the micro-RNA-1 (miR-1) (2013, Mus musculus,Homo sapiens)
• Pim-dependent inactivation of the negative regulator SOCS (2013, NA)
• Signaling pathways triggered by TCR and CD28 engagement (2013, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Caenorhabditis elegans,Coxsackievirus,NA)
• Main branches ofWnt signalling pathways in neuronal development (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Xenopus laevis,Phoenicopterus roseus,Homo sapiens,Agaricus bisporus)
• Pathway detail for the IPN: Mucus Hypersecretion model.Notes: The Mucus Hypersecretion model contains signaling detail from four main pathways known to induce airway MUC5AC production (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Listeria monocytogenes)
• Theoretical model for IL-10 production and its pathogenic role during DENV infection (2013, Human immunodeficiency virus 1,Human immunodeficiency virus,Dengue virus,Dengue virus type 2,Escherichia coli,Staphylococcus aureus,Homo sapiens,Mus musculus,NA)
• Action of cationic antitumor peptides (2013, NA)
• Canonical Wnt signaling pathway (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Insulin signaling pathways are inhibited by damage-associated molecular pattern (DAMP)-mediated, Toll-like receptor (TLR)-mediated pathways (2013, Homo sapiens,Mus musculus,Bos taurus,Mycobacterium tuberculosis)
• Diving adaptations in the Chinese alligator genome (2013, Gallus gallus,Danio rerio,Xenopus laevis,Meleagris gallopavo,Oryzias latipes,Dipnomorpha,Xenopus tropicalis,Tetrapoda,Tetraodon nigroviridis,Amniota,Taeniopygia guttata,Zootoca vivipara,Gasterosteus aculeatus,Anolis carolinensis,Sturnus vulgaris,Siniperca chuatsi,Alligator mississippiensis,Crocodylus siamensis,Alligator sinensis,Caiman crocodilus,Crocodylus palustris,Tomistoma schlegelii,Crocodylus niloticus,Bos taurus,Canis lupus familiaris,Ornithorhynchus anatinus,Monodelphis domestica,Loxodonta africana,Choloepus hoffmanni,Dasypus novemcinctus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Solanum tuberosum)
• Metastatic renal cell carcinoma: update on epidemiology, genetics, and therapeutic modalities (2013, Murid betaherpesvirus 1,Modified Vaccinia Ankara virus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• EpCAM and WNT signalling pathways (2013, NA)
• Mutations in various genes in the JAK/STAT pathway (MPL, CRLF2, JAK1, JAK3, JAK2, LNK, SOCS1, STAT3) implicated in hematologic malignancies (2013, NA)
• The leptin-induced pathways (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Yeast pathway map of nucleotide degradation and ribose salvage (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli IS1,Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Altered CREB/E2F1 signalling networks in co-treated HMCs (2013, NA)
• Signaling pathways involving EPCAM, proposed by Maetzel D et al (2013, Homo sapiens)
• Analyses of differentially expressed genes regulated by fasting in all three tissues revealing an involvement of p53 and Srebp signaling pathway (2013, NA)
• Known and novel roles of the p38-MK2/3 signaling pathway in cross-striated muscles (2013, NA)
• Proposed scheme of attenuation of cancer prosurvival signaling pathways by mitochondria-targeted antioxidants (2013, Homo sapiens,Mus musculus)
• Surfactant therapy and antioxidants work through the same pathway to enhance efferocytosis (2013, NA)
• Protein Kinase R Modulates c-Fos and c-Jun Signaling to Promote Proliferation of Hepatocellular Carcinoma with Hepatitis C Virus Infection (2013, NA)
• KEGG mapping for cell cycle pathway (2013, NA)
• Reactivation of HIV-1 transcriptional latency (2013, Homo sapiens,Human immunodeficiency virus 1)
• Glucose–fatty acid cycle (2013, NA)
• Simplified diagram of signal pathway convergence at downstream nuclear targets (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Bacterial interference with canonical NFKB signalling (2013, NA)
• Apoptosis pathways (2013, NA)
• Synergy between RasGRP and SOS in TCR signaling (2013, Mus musculus,Homo sapiens)
• Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus (2013, Staphylococcus aureus,Homo sapiens)
• Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway (2013, Saccharomyces cerevisiae,Saccharomyces bayanus,Saccharomyces kudriavzevii,Saccharomyces paradoxus,Lachancea kluyveri,Naumovozyma castellii,Saccharomyces mikatae,Human immunodeficiency virus 1,Rous sarcoma virus,Saccharomyces cerevisiae virus L-A,Escherichia coli,Escherichia coli DH5alpha,Homo sapiens,vectors,NA)
• Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma (2013, Homo sapiens,Mus musculus,Bos taurus,Escherichia coli)
• Autophagy can be targeted at multiple points on its regulatory pathways (2013, Homo sapiens,Saccharomyces cerevisiae)
• Proposed mechanism by which G6P accumulation regulates load‐induced mTOR activation and ER stress (2013, NA)
• Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Armoracia rusticana,Tetronarce californica)
• Acute-Phase Serum Amyloid A in Osteoarthritis: Regulatory Mechanism and Proinflammatory Properties (2013, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Candida dubliniensis,Murine leukemia virus)
• Pathways for WB-induced apoptosis and cell cycle arrest in SMMC-7721 cells (2013, Armoracia rusticana,PX clade,Citrus macrophylla,Aspergillus wentii,Polygonatum cyrtonema,Cerbera manghas,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Novel Strategy to Increase the Proliferative Potential of Adult Human Beta-Cells While Maintaining Their Differentiated Phenotype (2013, NA)
• Schematic presentation of the Wnt signaling pathway (2013, Aequorea victoria,Discosoma sp.,Homo sapiens,Mus musculus,Gallus gallus,Equus caballus)
• Analysis and Prediction of Pathways in HeLa Cells by Integrating Biological Levels of Organization with Systems-Biology Approaches (2013, Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,Alphapapillomavirus 7,Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Rhizobium etli)
• Insulin-like signaling pathway (2013, Caenorhabditis elegans,Homo sapiens)
• Antimicrobial peptides and gut microbiota in homeostasis and pathology (2013, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Clostridioides difficile,Campylobacter jejuni,Citrobacter rodentium,Neisseria gonorrhoeae,Bifidobacterium longum,Helicobacter hepaticus,Escherichia coli Nissle 1917,Salmonella enterica subsp. enterica serovar Enteritidis,Escherichia coli NC101,Enterocloster clostridioformis,Ruminococcus sp.,Ruminococcus bromii L2-63,Mus musculus,Rattus norvegicus,Influenza A virus,Human alphaherpesvirus 2,Homo sapiens,Saccharomyces cerevisiae,gut metagenome,Dipturus trachyderma,Trichinella spiralis)
• Notch signaling pathway (2013, Homo sapiens)
• Wnt signaling pathway (2013, NA)
• Signaling pathways of anti-permeability factors (2013, NA)
• Diagram illustrating the phagocytic signaling pathway initiated by TLR4-linked JAK2 activation during the internalization of B (2013, Brucella abortus)
• Inflammatory adipokines suppress insulin signaling resulting in insulin resistance (2013, NA)
• MSP-RON signaling pathway (2013, NA)
• Exploiting the head and neck cancer oncogenome: Widespread PI3K-mTOR pathway alterations and novel molecular targets (2013, NA)
• TRAIL apoptotic pathway (2013, Homo sapiens,Mus musculus)
• Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy (2013, NA)
• Antioxidant and Anti-Inflammatory Effects in RAW264.7 Macrophages of Malvidin, a Major Red Wine Polyphenol (2013, NA)
• Pathways of GPL biosynthesis in eukaryotic cells: temporal regulation of GPL-synthesizing enzyme activities (2013, NA)
• Canonical, non-canonical and the atypical NFKB signaling pathway (2013, NA)
• Heterotrimeric G-Protein, GA16, Is a Critical Downstream Effector of Non-Canonical Wnt Signaling and a Potent Inhibitor of Transformed Cell Growth in Non Small Cell Lung Cancer (2013, Mus musculus,Rattus norvegicus,Armoracia rusticana,Matthiola incana,Homo sapiens,Bos taurus,vectors)
• Saccharomyces cerevisiae Assay System to Investigate Ligand/AdipoR1 Interactions That Lead to Cellular Signaling (2013, Saccharomyces cerevisiae,Homo sapiens)
• Basic NOD2/RIP2 pathway of NFKB activation (2013, NA)
• Schematic depiction of LB-205 effects on NGF stimulated pathways (2013, NA)
• Predicted metabolic pathways of phylotype TM6SC1 (2013, metagenome,metagenomes,Candidatus Dependentiae)
• Different models of Hh signaling pathway activation in cancer (2013, NA)
• Constitutive components and the transduced mechanisms of Hh signaling pathway (2013, NA)
• Schematic diagram for HIF-1A functions in cap-dependent translation of selective mRNAs, cell proliferation, and tumorsphere growth of cancer cells in low O2 environment (2013, Homo sapiens)
• Profiling and Quantifying Differential Gene Transcription Provide Insights into Ganoderic Acid Biosynthesis in Ganoderma lucidum in Response to Methyl Jasmonate (2013, NA)
• Crosstalk between the RA-activated p38MAPK pathway and the expression of RAR target genes (2013, NA)
• The canonical and noncanonical NFKB pathway (2013, NA)
• CD4+ follicular helper T cell infiltration predicts breast cancer survival (2013, NA)
• CD4+ follicular helper T cell infiltration predicts breast cancer survival (2013, NA)
• Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia (2013, NA)
• Reciprocal regulation by TLR4 and TGFB in tumor-initiating stem-like cells (2013, NA)
• Translation regulation of the mTOR signaling pathway and translation process (2013, NA)
• Schema of regulatory mechanisms of endothelial atherosusceptibility discussed in the text (2013, NA)
• Extranuclear and nontranscriptional effects of RA and vitamin A (2013, NA)
• Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment (2013, NA)
• Simplified schematic of cholesterol and lipid synthesis including major regulatory elements and feedback points (2013, NA)
• Autophagy: regulation (2013, NA)
• Schematic overview of hippocampal signaling pathways following sleep deprivation (2013, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Felis catus,Homo sapiens,Drosophila melanogaster)
• Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer (2013, NA)
• Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia (2013, NA)
• Cellular mechanism of the LPS in the liver and interaction of PPARA at several levels of the inflammatory signaling pathway (2013, NA)
• Immunosuppressants in cancer prevention and therapy (2013, Human gammaherpesvirus 4,Human papillomavirus,Human betaherpesvirus 5,Myxoma virus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Nicotiana tabacum,Homo sapiens,Mus musculus,NA)
• Novel Phosphopeptide Microarray Based Interactome Map in Breast Cancer Cells Reveals Phosphoprotein-GRB2 Cell Signaling Networks (2013, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Mouse mammary tumor virus,clinical samples,Triportheus paranensis)
• Towards Systematic Discovery of Signaling Networks in Budding Yeast Filamentous Growth Stress Response Using Interventional Phosphorylation Data (2013, Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Venustaconcha ellipsiformis)
• Interferon A interferes with immunological tolerance (2013, Homo sapiens)
• Role played by PDKs in malignant gliomas (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic model of novel cytoprotective mechanisms in response to oxidative stress in Beta-thalassemic (Beta-thal) erythroid precursors (2013, Saccharomyces cerevisiae,Carica papaya,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Plasmodium falciparum)
• RasC/TORC2 regulation by chemokine signaling (2013, NA)
• Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab (2013, Homo sapiens)
• Evidence for indirect influence of kinases on tau phosphorylation (2013, Homo sapiens,Mus musculus)
• GeneGo pathway map translation regulation of eIF2 activity (2013, Homo sapiens,Mus musculus)
• Proposed model of SDF-1-induced apoptosis (2013, Homo sapiens)
• Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells (2013, Homo sapiens)
• JAK-STAT signaling within the CNS (2013, NA)
• Regulation of lipid metabolism in glioblastoma and the therapeutic drug targets (2013, NA)
• IGF-1-Induced Enhancement of PRNP Expression Depends on the Negative Regulation of Transcription Factor FOXO3a (2013, Bos taurus,Ovis aries,Homo sapiens,Mus musculus,Caenorhabditis elegans,prion,Human adenovirus 5)
• Conservation between the Drosophila and the mammalian JAK/STAT pathway and their commonalities in inducing systemic and localized immune response and tissue growth (2013, Escherichia coli,Pseudomonas aeruginosa,Vibrio cholerae,Enterococcus faecalis,Lactiplantibacillus plantarum,Serratia marcescens,Escherichia coli PA14,Pseudomonas entomophila,Acetobacter pomorum,Escherichia coli NC101,Pseudomonas aeruginosa CF5,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Ovis aries,Human parvovirus B19)
• CHC-1 and EPN-1 promote actin polymerization in response to CED-1 signaling (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae)
• Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Zea mays,Macaca mulatta,Ophiocordyceps sinensis,Bos taurus,Dipturus trachyderma,Betapolyomavirus macacae)
• Proposed breast cancer signaling pathway based on the KEGG network pathway analysis of hypoxia-activated tumor cell migration (2013, NA)
• HFPN model of extended center metabolism pathway in E (2013, NA)
• Basic regulation mechanisms required in the process of a cell utilizing glucose and glycogen (2013, NA)
• After the banquet (2013, Homo sapiens)
• PI3K/Akt/mTOR signaling pathway ] (2013, NA)
• Homocysteine metabolic pathways (2013, Arachis hypogaea,Salvia miltiorrhiza,Sesamum indicum,Sclerotinia sclerotiorum,Homo sapiens,Rattus norvegicus)
• Cancer-relevant pathways affected by HSP70 (2013, Homo sapiens,Mus musculus)
• Proposed model of the intracellular signals necessary for the GLP-1R activation-mediated suppression of food intake (2013, NA)
• Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCA Promotes both RhoA and Rac1 Signaling (2013, NA)
• Propolis Augments Apoptosis Induced by Butyrate via Targeting Cell Survival Pathways (2013, NA)
• Regulation of the HIF pathway by oxygen dependant and independent mechanisms (a) Under normoxia, prolyl hydroxylase domain proteins use oxygen and Alpha-ketoglutarate as substrates to hydroxylate conserved proline residues on HIFA subunits (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• mTOR pathway (2013, Homo sapiens)
• Central Ras/cAMP/PKA signaling pathway components and examples of signals to which the Ras signaling pathway responds (2013, Candida albicans,Homo sapiens)
• Cell compartment view for network of lipid metabolic genes highlighting the role of SREBF1, THRSP, and ESRRA curated by ingenuity pathway analysis (IPA) (2013, NA)
• Schematic model for BA-TPQ-induced MCF7 cell apoptosis (2013, Homo sapiens,Mus musculus)
• Proposed mechanisms involved in the increase of SMN expression induced by ERK inhibition in the spinal cord of severe SMA-like mice (2013, NA)
• mTOR信号通路mTOR signaling pathway (2013, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• Signaling pathways activated by E2 and its crosstalk with GH (2013, NA)
• Signaling pathways used by GH to regulate growth and metabolism (2013, NA)
• Model by which the dynorphin/kappa system could counteract cocaine-induced dopamine release (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Cavia porcellus,Macaca mulatta,Macaca fascicularis,Nicotiana tabacum,Salvia divinorum,Oryctolagus cuniculus)
• Functional Networking of Human Divergently Paired Genes (DPGs) (2013, NA)
• Complexity of signaling in the cell (2013, NA)
• An illustration of how diversified signaling pathways are achieved via allostery in G protein-coupled receptors (GPCR), also known as seven-transmembrane spanning receptors (7TMR) (2013, NA)
• Canonical pathway analysis (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus,Capra hircus,unidentified influenza virus)
• Genomic landscape of small intestine neuroendocrine tumors (2013, NA)
• Iron regulation by hepcidin (2013, NA)
• Proposed model for the attenuated response to type I IFNs in human pluripotent cells (2013, Homo sapiens)
• Proposed scheme of the effects of up-regulation of HO-1 by PPARG activation on HMGB1-RAGE signaling pathway in ALI/ARDS (2013, NA)
• Wnt signaling pathways (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Bos taurus,Danio rerio,Lareunionomyces loeiensis,Thermochromatium tepidum)
• LRRK2 regulates cell biological functions important for neurogenesis (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Bos taurus,Danio rerio,Lareunionomyces loeiensis,Thermochromatium tepidum)
• Specification of GABAergic Cortical Interneurons (2013, NA)
• Possible post-junctional mechanisms responsible for cholinergic excitation (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Homo sapiens,Canis lupus familiaris)
• Receptors involved in allergen recognition and uptake by AECs (2013, Schistosoma mansoni,Blattella germanica,Dermatophagoides pteronyssinus,Arachis hypogaea,Ambrosia artemisiifolia,Homo sapiens,Mus musculus,Canis lupus familiaris)
• Combined miRNAs and transcription factor regulation of inflammation in wound healing (2013, NA)
• Resistance to EGFR targeted therapies (2013, NA)
• How the VEGF-A signaling pathway is linked to its main biological functions.Notes: VEGF-A can bind VEGFR-2 dimer (2013, NA)
• EGFR pathway and its main downstream effectors, PI3K/AKT and KRAS/BRAF/MEK/MERK.Notes: Activated AKT and MEK/MERK can induce cancer cell proliferation and invasion (2013, NA)
• Model showing the cRAF-dependent modulation of DC responses by TcES (2013, NA)
• Regulators of ATP7A trafficking (2013, Saccharomyces cerevisiae,Bikinia letestui,Homo sapiens,Mus musculus,Bos taurus,Danio rerio,Human immunodeficiency virus 1)
• Antagonistic Regulation of Flowering Time through Distinct Regulatory Subunits of Protein Phosphatase 2A (2013, NA)
• Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1B — A Possible Pathway of Exacerbations in COPD (2013, NA)
• DA biosynthesis and degradation (2013, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Sus scrofa,Cavia porcellus,Homo sapiens,Drosophila melanogaster,Adeno-associated virus,Cytisus scoparius)
• Sonic hedgehog-Dependent Induction of MicroRNA 31 and MicroRNA 150 Regulates Mycobacterium bovis BCG-Driven Toll-Like Receptor 2 Signaling (2013, Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Moraxella bovis,Homo sapiens,Mus musculus)
• (A–E) Graphical representation of the metabolic flux distribution in the central carbon metabolism at the indicated time points (2013, Homo sapiens,Saccharomyces cerevisiae)
• Nitric oxide-sphingolipid interplays in signalling (2013, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Medicago truncatula,Artemisia annua,Fusarium verticillioides,Fusarium sp.,Alternaria alternata f. sp. lycopersici,Mus musculus,Rattus norvegicus,Escherichia coli,Pseudomonas syringae,Homo sapiens)
• Intracellular signaling pathways regulated by the leptin receptor (LepRb) in the central nervous system (2013, NA)
• Regulation of upregulated miRNAs on the downregulated mRNAs in antigen processing and presentation pathway and p53 signaling pathway (2013, NA)
• Adult haemangioblast genetic regulatory network (2013, NA)
• Metabolism in skeletal myoblasts and myotubes (2013, NA)
• Metabolism in differentiating embryonic stem cells (2013, NA)
• Metabolism in pluripotent stem cells (2013, NA)
• Metabolism in totipotent stem cells (2013, NA)
• Evolution of the Ink4a tumor suppressor locus in vertebrates (2013, NA)
• Functional Beta-cells respond to increasing glucose levels by increasing insulin secretion (2013, NA)
• Signaling-activated kinases regulate splicing factor activity (2013, Homo sapiens,Mus musculus)
• GHS-R1a constitutive activity leads to the dissociation of A and BG subunits of heterotrimeric G-proteins (2013, NA)
• Model depicting the molecular mechanism of ATRA resistance in lung cancer (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• CD25 and CD69 induction by A4B1 outside-in signalling requires TCR early signalling complex proteins (2013, NA)
• Schematic overview of signalling pathways and drug targets currently under investigation in CML research (2013, Homo sapiens)
• The putative steps in the redox signaling pathway leading to adaptive activation of transcription factors and upregulation of the expression of cytoprotective proteins following contractile activity in skeletal muscle (2013, NA)
• Cumulative scheme adapted from the data published in (, –, , , , , ) showing components of pathways implicated in regulating the life span in Drosophila and their interactions (2013, Drosophila melanogaster,Homo sapiens)
• Innate immune system in pneumococcal meningitis infection (2013, NA)
• Nrf2 target genes in APAP metabolism (2013, NA)
• Signaling pathway in Nrf2 activation by HCV infection (2013, NA)
• Pathway members of insulin/Akt signalling, TGFB, wnt signalling and inflammatory pathways that were regulated by prednisolone in 3T3-L1 cells (2013, Bos taurus,Canis lupus familiaris,Capra walie,Mus musculus,Rattus norvegicus,Coccoloba uvifera,Allium ampeloprasum,Homo sapiens,Drosophila melanogaster)
• L-arginine-NO-cGMP signalling pathway in pancreatitis (2013, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus asinus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• The epigenetic modification and a hypothetical complex transcription (2013, NA)
• YKL-40 induces angiogenic signaling in endothelial cells (2013, Homo sapiens,Mus musculus,Bos taurus,Allium ampeloprasum)
• Schematic diagram of the IP3 cytoplasmic Ca2+ branch of the PLC-mediated GqPCR signaling pathway studied in Dickson et al (2013, NA)
• Interaction of the EGF and TGFB pathways in the control of proliferation in breast cancer (2013, NA)
• Pathway summary of peptide array and antibody array results (2013, NA)
• New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer (2013, NA)
• Mechanism of activity-dependent transcriptional repression by MeCP2 (2013, NA)
• New Algorithm for Integrated Analysis of miRNA-mRNA Interactions Based on Individual Classification Reveals Insights into Bladder Cancer (2013, NA)
• Activation of the EGFR pathway and the consequent engagement of the Ras/Raf/MAPK and PI3K/Akt pathways (2013, NA)
• The regulation of TLR signaling by Lgr4 (2013, NA)
• Schematic diagram illustrates the role of Dapper3 in UUO-induced renal fibrosis by regulating Wnt/Beta-catenin signaling (2013, Mus musculus,Homo sapiens)
• Schematic representation summarizing the putative intracellular events involved in PACAP-induced NFKB activation in PC12 cells (2013, Rattus norvegicus,Homo sapiens)
• Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer (2013, NA)
• Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer (2013, NA)
• Notch signaling pathway (2013, Discosoma sp.,Phrixothrix hirtus,Rhagophthalmus ohbai,Canis lupus familiaris,Mustela putorius furo,Homo sapiens,Mus musculus)
• Autocrine and paracrine effects of transforming growth factor (TGF)B on melanoma cells and tumor microenvironment (2013, NA)
• Transforming growth factor (TGF)B signaling cascade (2013, NA)
• Physiologic hemoglobin scavengers and detoxification systems (2013, NA)
• Insulin resistance as trigger of atherothrombosis (2013, NA)
• Hyperglycemia-induced vascular damage (2013, NA)
• Role of Nox-derived ROS in Ang II-mediated effects in vascular cells (2013, NA)
• Proposed model illustrating the mechanism of arctigenin-mediated AB production inhibition and AB clearance promotion (2013, NA)
• Structure of the EP4 receptor and its activation of signaling modules (2013, NA)
• Receptor-mediated regulation of KATP channels (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Phaseolus vulgaris,Prunus domestica,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Intrinsic somatodendritic and presynaptic modulation of action potential (AP) firing and transmitter release in 5-HT neurons (2013, NA)
• Cadherin 6 Is a New RUNX2 Target in TGFB Signalling Pathway (2013, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human betaherpesvirus 5)
• Selected AMPK and IGF-IR signalling pathways relevant to this study in normal (A) and hyperglycaemic (B) conditions (2013, Homo sapiens,Bos taurus,Gallus gallus,Nicotiana tabacum)
• The TLR family protein RP105/MD-1 complex (2013, Homo sapiens,Mus musculus,Bos taurus)
• Major apoptotic pathways in SGNs induced by oubain treatment (2013, NA)
• Schematic cartoon portraying the apoptotic signalling pathway triggered by anandamide (AEA) in rat decidual cells (2013, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Cannabis sativa)
• Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway (2013, unidentified influenza virus,Dengue virus,Vesicular stomatitis virus,Homo sapiens,Mus musculus,Listeria monocytogenes)
• Involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis (2013, NA)
• Components involved in translocation of phospholipids to and within mitochondria of yeast (2013, NA)
• Hypothetical role of the AhR pathway in the development of inflammatory bowel disease after exposure to environmental PAH (2013, NA)
• General activation of interferonB (IFNB) transcription and induction of IFN-stimulated genes (2013, Rift Valley fever virus,La Crosse virus,Human immunodeficiency virus 1,Tobacco mosaic virus,Semliki Forest virus,Severe fever with thrombocytopenia syndrome virus,Tomato mosaic virus,Bunyamwera virus,Uukuniemi virus,Heartland virus,Schmallenberg virus,Toscana virus,Akabane virus,California encephalitis virus,Impatiens necrotic spot virus,Brazoran virus,Tomato yellow ring virus,San Angelo virus,Drosophila melanogaster,Aedes aegypti,Aedes albopictus,Culex quinquefasciatus,Chironomus thummi,Frankliniella occidentalis,Culicoides arakawae,Saccharomyces cerevisiae,Nicotiana tabacum,Solanum lycopersicum,Capsicum annuum,Bos taurus,Capra hircus,Ovis aries,Homo sapiens,Mus musculus,Meleagris gallopavo,NA,NA,NA,NA,NA,NA,NA,NA,NA)
• Osteoclastogenesis (2013, NA)
• Intracellular signaling pathways recruited by leptin (2013, NA)
• Oncostatin M signaling pathway- NetSlim (http://www.netpath.org/netslim/NetSlim_114) map generated to graphically represent the different reactions induced by OSM in various cell types (2013, NA)
• Enriched Environment Prevents Hypobaric Hypoxia Induced Memory Impairment and Neurodegeneration: Role of BDNF/PI3K/GSK3B Pathway Coupled with CREB Activation (2013, Mus musculus,Rattus norvegicus,Rattus rattus,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana)
• Function of Wnt signaling during synapse development and maintenance (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Clinitrachus argentatus)
• Wnt7a signals bi-directionally at vertebrate synapses (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Clinitrachus argentatus)
• Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3B, Neurotrophin-3 and CREB Signaling (2013, NA)
• Gene pathways revealed by comprehensive genomic profiling (2013, Homo sapiens,Rattus norvegicus)
• Model describing Etv4 and Etv5 induction following distal NGF stimulation (2013, Rattus norvegicus,Gallus gallus,Homo sapiens)
• Working model of renoprotective pathways activated by relaxin (2013, NA)
• Tumour dormancy and clinical implications in breast cancer (2013, NA)
• Extrinsic and intrinsic apoptotic pathways (2013, Homo sapiens)
• Proposed scheme for the role of mTOR in p53-induced kidney cell injury (2013, NA)
• Isobutanol pathways (2013, NA)
• Regulation of Gq- and Gi-coupled receptor signaling by caveolin-1 in gastric smooth muscle (2013, NA)
• Summary of therapeutic invention points in the myostatin signaling pathway (2013, Homo sapiens,Mus musculus,Canis lupus familiaris,Sorghum bicolor,Corvus frugilegus)
• How are STAT1 and cholesterol metabolism associated in antiviral responses? (2013, Human gammaherpesvirus 4,Human alphaherpesvirus 1,unidentified influenza virus,Murid betaherpesvirus 1,Human alphaherpesvirus 3,Murid herpesvirus 68,Homo sapiens,Mus musculus,NA)
• RAS-directed silencing of TSGs (2013, NA)
• Combined miRNA/mRNA regulatory and functional enrichment network (2013, NA)
• Intracellular effects of soluble mediators are mainly mediated through the interaction with specific receptors that link extracellular signals up to modulation of gene expression (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Aedes aegypti)
• Transcriptional feedback in the insulin signalling pathway modulates ageing (2013, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Integration of Cell Signalling Pathways into Higher Order Networks Sculpts Transcriptional Landscapes (2013, NA)
• Transcriptional feedback in the insulin signalling pathway modulates ageing (2013, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Highest scoring upregulated network: Cellular Assembly (2013, Rattus norvegicus,Homo sapiens)
• Schematic diagram illustrating the Nrf2 pathway and other signaling pathways triggered by exposure to mollugin in in OSCCs (2013, Armoracia rusticana,herbal medicine,Biancaea sappan,Rubia cordifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Human papillomavirus)
• Scheme depicting the current knowledge on PAC1-mediated signaling cascades resulting in a variety of neuronal outcomes (2013, Gallus gallus,Danio rerio,Oncorhynchus mykiss,Carassius auratus,Dipnomorpha,Pagrus pagrus,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Bos taurus,Oryctolagus cuniculus,Allium tricoccum,Morchella esculenta,Homo sapiens,Metaphire sieboldi)
• Natural Borneol, a Monoterpenoid Compound, Potentiates Selenocystine-Induced Apoptosis in Human Hepatocellular Carcinoma Cells by Enhancement of Cellular Uptake and Activation of ROS-Mediated DNA Damage (2013, Armoracia rusticana,Nicotiana tabacum,Lavandula angustifolia,Hericium erinaceus,Valeriana officinalis,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Calloplesiops altivelis)
• FluMap, a comprehensive IAV pathway map (2013, Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Orthomyxoviridae,H1N1 subtype,West Nile virus,H5N1 subtype,Variola virus,Influenza A virus H3N2,H9N2 subtype,Influenza B virus,Drosophila melanogaster,Gallus gallus,Canis lupus familiaris,Equus caballus,Anas platyrhynchos,Aequorea victoria,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Metabolically controlled apoptosis pathway of Myc (2013, Mus musculus,Homo sapiens)
• Model: Myc-induced altered metabolism activates AMPK and p53, which sensitizes the mitochondrial apoptosis pathway (2013, Mus musculus,Homo sapiens)
• Age-related alteration of gene expression in the TCR signaling pathway (2013, NA)
• The PI3K/Akt pathway (2013, Homo sapiens,Cerobasis alpha)
• The c-MET pathway (2013, Homo sapiens,Cerobasis alpha)
• The signaling pathways involved in calpain-mediated regulation of dendritic protein synthesis induced by BDNF (2013, NA)
• ERK and non-ERK mediated non-genomic AR signaling (2013, Mus musculus,Rattus norvegicus,Bos taurus,Mustela lutreola,Homo sapiens)
• Signaling pathways in PCSCs (2013, NA)
• Wnt signaling and its implications in the development of prostate cancer (2013, NA)
• TGFB/SMAD signaling pathway and its implication in prostate cancer (2013, NA)
• ERK and PI3K activation and their crosstalk (2013, NA)
• PI3K/AKT signaling in prostate cancer (2013, NA)
• Androgen receptor (AR) signaling in prostate cancer (2013, NA)
• Integration of 1H NMR and UPLC-Q-TOF/MS for a Comprehensive Urinary Metabonomics Study on a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress (2013, NA)
• PKC Activation Induces Inflammatory Response and Cell Death in Human Bronchial Epithelial Cells (2013, Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens,Moraxella catarrhalis)
• Identification of the genes in the MAPK signaling pathway that harbor or are in the close proximity of SNPs associated with feed efficiency (2013, Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Cervus elaphus,Homo sapiens,Rattus norvegicus,Zea mays)
• Drosophila JAK-STAT pathway in blood cell formation and immunity (2013, Drosophila melanogaster,Homo sapiens)
• The pathway triggered by Tat and leading to activation of ISGs by Tat in APCs infected by HIV (2013, NA)
• Myostatin (Mstn) pathway (2013, Homo sapiens)
• Model for a calcineurin-dependent pathway linking specific patterns of motor nerve activity to distinct programs of gene expression that establish phenotypic differences between slow and fast myofibers (2013, Homo sapiens)
• Schematic overview of TGFB signaling (2013, NA)
• Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the GAq/11 - p63RhoGEF - RhoA Axis (2013, NA)
• Acetylcholine Promotes Ca2+and NO-Oscillations in Adipocytes Implicating Ca2+→NO→cGMP→cADP-ribose→Ca2+ Positive Feedback Loop - Modulatory Effects of Norepinephrine and Atrial Natriuretic Peptide (2013, NA)
• Acetylcholine Promotes Ca2+and NO-Oscillations in Adipocytes (2013, NA)
• Roles of lipids in the tumour microenvironment (2013, NA)
• Dual Regulation of Cadmium-Induced Apoptosis by mTORC1 through Selective Induction of IRE1 Branches in Unfolded Protein Response (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Linking Transcriptional Changes over Time in Stimulated Dendritic Cells to Identify Gene Networks Activated during the Innate Immune Response (2013, NA)
• Modeling Integrated Cellular Machinery Using Hybrid Petri-Boolean Networks (2013, NA)
• Representative Tyr phosphorylation sites affected by erlotinib in the EGFR and ErbB2 canonical pathways (2013, NA)
• Leptin deficiency disturbs the insulin signaling pathway JAK2/IRS/PI3K/AKT/AMPK and triggers diabetes (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Drosophila JAK-STAT pathway in blood cell formation and immunity (2013, Drosophila C virus,Sigma virus,Antarctic picorna-like virus,Pectobacterium carotovorum subsp. carotovorum,Pseudomonas entomophila,Homo sapiens,Drosophila melanogaster)
• PI3K–PKCλ–AMPAR signalling pathway (2013, NA)
• Importance of white adipose tissue (WAT)–skeletal muscle crosstalk in cancer associated cachexia (CAC) and/or lipotoxicity (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis)
• Diagram showing some of the downstream elements of the proposed Hippo pathway (2013, NA)
• Diagram showing some of the upstream elements of the proposed Hippo pathway (2013, NA)
• Peritumoral (P) activated hepatic stellate cells (HSCs) and intratumoral myofibroblasts (T) (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis,Hepatitis B virus,NA)
• Glycan-mediated modification of the immune response (2013, Homo sapiens,Mus musculus,Enterovirus C)
• “molecular switch” role of CREB in hippocampal‐dependent memory consolidation (2013, Homo sapiens,Rattus norvegicus)
• ERK1/2-mediated regulation of the G1-S phase transition (2013, NA)
• Pathway of nucleotide excision repair and translesion synthesis (2013, Panthera tigris,Eutheria,Homo sapiens,Nicotiana tabacum)
• A typical eukaryotic cell division cycle (2013, NA)
• Cellular response to oxidative stress mediating by Beta-adrenergic response and sirtuins involvement (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Corynephage beta)
• Toll-Like Receptor -1, -2, and -6 Polymorphisms and Pulmonary Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis (2013, Staphylococcus aureus,Mycobacterium tuberculosis,Borreliella burgdorferi,Treponema pallidum,Staphylococcus aureus Chi-4,Rickettsia akari,Rickettsia akari str. Croatia,Danio rerio,Meleagris gallopavo,Homo sapiens,Mus musculus,Bos taurus)
• TLR4 Activates the Beta-catenin Pathway to Cause Intestinal Neoplasia (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Citrobacter rodentium)
• Schematic representation and overview of PI3K/AKT/mTOR/PTEN signaling (2013, NA)
• Several inhibitors linked to the PI3K/AKT/mTOR/PTEN signaling pathway are shown (2013, NA)
• Summary of YY1 gene network expression in steers comparing early weaning (EWS) against normal weaning without creep feeding (NWN) at 240 days on treatment.Notes: Cellular locations depicted are from the Ingenuity Pathway Analysis® knowledge base (2013, Zea mays,Glycine max,Medicago sativa,Trifolium pratense,Trifolium repens,Lolium arundinaceum,Poa pratensis,Dactylis glomerata,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Labeobarbus longissimus)
• Yin Yang 1 and Adipogenic Gene Network Expression in Longissimus Muscle of Beef Cattle in Response to Nutritional Management (2013, Zea mays,Glycine max,Medicago sativa,Trifolium pratense,Trifolium repens,Lolium arundinaceum,Poa pratensis,Dactylis glomerata,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Labeobarbus longissimus)
• Role of miR-302 during human ESCs (hESC) neural differentiation (2013, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• Signaling pathways associated with GDT cell cytotoxicity and cytokine production (2013, NA)
• Possible signal pathway activated by cathelicidin (LL-37) to inhibit cell proliferation in gastric cancer cells (2013, NA)
• Effect of physical activity and obesity on the growth and development of colon carcinogenesis (2013, Homo sapiens,Nicotiana tabacum)
• Effect of cigarette smoke on the etiology of colon carcinogenesis (2013, Homo sapiens,Nicotiana tabacum)
• Wnt ligands induce diverse Wnt pathways (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Beta-Catenin plays two main functions in the cell (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• ERK1/2-mediated regulation of the BCL2 protein family (2013, NA)
• Peroxisome Proliferator-Activated Receptor (PPAR) G and PPARA Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders? (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Glycolytic phenotype cancer cell may be treated by DCA (2013, NA)
• Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease Due to Chronic Inhaled Endotoxin (2013, NA)
• Thymidylate Synthase Expression Determines Pemetrexed Targets and Resistance Development in Tumour Cells (2013, Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana)
• The molecular signalling responsible for the differentiation-specific induction of Keratin 15 (K15) expression (2013, NA)
• Schematic overview of Hedgehog signaling and rationale for combination therapy with (chemo)radiotherapy (2013, Drosophila melanogaster,Olea europaea,Antarctothoa delta,Veratrum californicum,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Microarray analysis also indicated an increase in Wnt signaling and cell cycle regulation in women (2013, unidentified influenza virus,H1N1 subtype,Homo sapiens,Mus musculus,Bos taurus,gut metagenome)
• Hedgehog signaling pathway, a morphogenic signaling pathway important in embryogenesis, tissue differentiation, cell growth and development (2013, NA)
• Signaling pathway of checkpoint control and IR-induced perturbation (2013, NA)
• Illustration showing the activation of a T lymphocyte (via a three‐signal pathway) by an antigen‐presenting cell (2013, NA)
• Cholesterol synthesis pathway (2013, Armoracia rusticana,Glycine max,Bikinia media,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Ageing-dependent decline in thyroid activity, leading to compensatory increases in cellular D1 activity and thyroid hormone metabolites that may, through non-genomic pathways, be involved in amelioration of ageing related metabolic disturbances (2013, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae)
• AGE-RAGE, oxidative stress and amplification loops linked to the pathogenesis of chronic disease (2013, NA)
• A simplified summary of the signaling involved in response to TPA and leading to the process of EMT on HepG2 cells (2013, NA)
• Melatonin molecular signaling pathways in Plasmodium (2013, Plasmodium falciparum,Homo sapiens)
• Proposed schematic for events involved in p300/Beta-catenin- and CCN-dependent alveolar epithelial repair (2013, NA)
• Targeting immunosuppressive molecular pathways in EC (2013, Homo sapiens,Mus musculus)
• Biosynthetic pathway of major phospholipids in vascular endothelial tissue and mononuclear leukocytes (2013, Bos taurus,Capra hircus,Sus scrofa,Bison bison,Saccharomyces cerevisiae,Zea mays,Diaporthe sclerotioides,Mus musculus,Rattus norvegicus,Homo sapiens)
• TLR-4 signaling pathway.Notes: TLR-4/MD-2 complex homodimerization activates the MyD88-dependent pathway and TRIF-dependent pathway (2013, Escherichia coli,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Chlamydia trachomatis,Limosilactobacillus reuteri,Mycobacterium tuberculosis variant bovis BCG str. Sweden,Mycobacterium tuberculosis variant bovis BCG str. Mexico,Saccharomyces cerevisiae,Nicotiana tabacum,Aeginetia indica,Mus musculus,Cavia porcellus,Homo sapiens,Drosophila melanogaster,Human papillomavirus)
• Comparison of Cellular Uptake and Inflammatory Response via Toll-Like Receptor 4 to Lipopolysaccharide and Titanium Dioxide Nanoparticles (2013, Mus musculus,Rattus norvegicus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Bos taurus,Gallus gallus,vectors)
• E4orf4-induced cell death in normal Drosophila tissues (2013, NA)
• Toll-like Receptor (TLR) Signaling Pathways (2013, NA)
• Schematic pathway of different steps of autophagy (2013, NA)
• Post-translational regulation of iron homeostasis (2013, NA)
• Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder (2013, NA)
• Cross-talk between insulin and inflammatory signaling pathways (2013, NA)
• Synergistic Effect of Everolimus and Chloroquine on Endothelial Cell Number Reduction Is Paralleled by Increased Apoptosis and Reduced Autophagy Occurrence (2013, NA)
• Hypoxia-Induced Changes in the Bioactivity of Cytotrophoblast-Derived Exosomes (2013, Bos taurus,Armoracia rusticana,Capra hircus,Sequoia sempervirens,Homo sapiens,Mus musculus,Mouse mammary tumor virus,Tetronarce californica)
• Therapeutic molecular targets for endometrial cancer (2013, Homo sapiens,Mus musculus)
• Main lipid classes and biochemical pathways involved in the channelling of fatty acids into TAG in developing seeds (2013, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Zea mays,Glycine max,Diaporthe sclerotioides,Embryophyta,Matthiola incana,Brassica napus,Vicia faba,Physcomitrium patens,Brassica juncea,Phytophthora infestans,Linum usitatissimum,Phytophthora sojae,Ostreococcus tauri,Marchantia polymorpha,Emiliania huxleyi,Vicia faba var. minor,Hyaloperonospora parasitica,Claviceps purpurea,Globisporangium irregulare,Brassica carinata,Thraustochytrium sp.,Thraustochytrium sp. 1.3A4.1,Elsholtzia fruticosa,Agrobacterium tumefaciens,Coleofasciculus chthonoplastes,Homo sapiens,Trypanosoma brucei)
• Retinoblastoma: concerning its initiation and treatment (2013, Homo sapiens)
• MiR-103 Controls Milk Fat Accumulation in Goat (Capra hircus) Mammary Gland during Lactation (2013, Capra hircus,Homo sapiens)
• Summary of retinoid pathway (2013, NA)
• Pathways involved in the pathogenesis of dystrophic muscle (2013, Homo sapiens,Mus musculus)
• Post-translational modifications and interactions possibly involved in DSB repair pathway choice and HRR modulation (2013, NA)
• Simplified representation of the PI3K signaling pathway (2013, NA)
• Proposed mechanisms by which proline metabolism mediates redox homeostasis and energy production via NADP+/NADPH (2013, Homo sapiens)
• Plectin S4642 in HeLa cells (2013, NA)
• Core components of the apoptotic machinery (2013, NA)
• STL-based Analysis of TRAIL-induced Apoptosis Challenges the Notion of Type I/Type II Cell Line Classification (2013, NA)
• Normal endothelial function versus endothelial dysfunction (2013, NA)
• Canonical and noncanonical functions of the apoptotic machinery (2013, NA)
• Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease (2013, NA)
• Hepatic ethanol metabolism (2013, NA)
• Hepatic glucose metabolism (2013, NA)
• Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis (2013, NA)
• Outline of the Crosstalk between p53 Family Members and the mTORC1 Pathwayp53 and p63 act upstream of mTORC1 and inhibit mTORC1 activity via multiple transcriptional targets (2013, NA)
• TCDD-induced CTLA-4 on AhR-Treg activating the tolerogenic IDO pathway and suppressing the acute GVH response (2013, NA)
• Genes expressed higher in mutant mice revealed networks of interacting genes (2013, Diaporthe sclerotioides,Sequoia sempervirens,Vigna unguiculata subsp. cylindrica,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• Mechanisms involved in type I IFN production and its receptor signaling (2013, NA)
• Wnt signaling pathway (2013, NA)
• Alzheimer’s disease pathway from the KEGG database (2013, NA)
• Cytoskeletal modulation and signaling (2013, Chlamydia trachomatis,Chlamydia pneumoniae,Chlamydia muridarum,Chlamydia caviae,Candidatus Protochlamydia amoebophila UWE25,Candidatus Protochlamydia amoebophila,Homo sapiens,Mus musculus,unidentified influenza virus)
• Dysregulation of cellular networks in the presence of PAN RNA expression (2013, Human gammaherpesvirus 8)
• HPV16 binds to heparin sulfate proteoglycans (HSPGs) on either the epithelial cell surface or the basement membrane or through laminin-332 on the ECM (2013, NA)
• Survival pathways in CML progenitors and stem cells (2013, NA)
• Interrelations between autophagy-related signaling and cell growth control in response to stress (2013, NA)
• TGFB signaling through Smad-dependent and Smad-independent pathways (2013, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• TNFA signaling pathways to IKK activation (2013, Mus musculus,Homo sapiens)
• FGFR signaling pathway (2013, NA)
• Cross talk between the coagulation and complement system (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Causal association of microbial interaction with HIV-1 latency and AIDS progression (2013, Homo sapiens,Human immunodeficiency virus 2)
• PI3K pathway and sites of action of PI3K signaling pathway inhibitors in solid tumors and hematological malignancies (2013, NA)
• PMT deamidates and activates heterotrimeric GA proteins (2013, NA)
• Molecular inhibitory mechanism of cPAP to block proliferation and survival of prostate cells (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Xenotropic MuLV-related virus)
• Proposed signaling process for GDNF-independent UB outgrowth (2013, Diaporthe sclerotioides,Sequoia sempervirens,Vigna unguiculata subsp. cylindrica,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• Prognostic signature of G₂ checkpoint function in melanoma cell lines (2013, NA)
• Genome-Scale Modeling of the Protein Secretory Machinery in Yeast (2013, Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,prion,NA)
• Visualization of the six BioPAX example files, provided in BioPAX 3.0 documentation (2013, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• B-Raf protein and signaling pathways (2013, Homo sapiens,Mus musculus,Gallus gallus,Lareunionomyces loeiensis,clinical samples,Murine sarcoma virus 3611)
• KEGG “cell cycle” pathway relevant to NRF1 target genes (2013, NA)
• MicroRNA Profiling in Prostate Cancer - The Diagnostic Potential of Urinary miR-205 and miR-214 (2013, NA)
• KEGG “Parkinson’s disease” pathway relevant to NRF1 target genes (2013, NA)
• IPA “regulation of eIF4 and p70S6K signaling” pathway relevant to NRF target genes (2013, NA)
• Janus face of cyclophosphamide (2013, NA)
• Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target (2013, NA)
• Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks (2013, NA)
• Toll-Like Receptors (TLR) signaling pathway involved in RSV and hMPV-induced gene expression (2013, NA)
• Intracellular PRR signaling pathways involved in RSV and hMPV-induced gene expression (2013, NA)
• Diagram of PI3K/Akt and Ras/Raf pathway (see text for details) (2013, Homo sapiens,Mus musculus,Equus caballus,adeno-associated virus 2,Terfezia morenoi)
• Schematic overview of the purinergic signalling pathway involved in P2Y receptor activation leading to N-cadherin expression in Schwannoma cell line (2013, NA)
• miRNA Signature of Mouse Helper T Cell Hyper-Proliferation (2013, Homo sapiens,Mus musculus,Heligmosomoides polygyrus)
• Developmental Gene Discovery in a Hemimetabolous Insect: De Novo Assembly and Annotation of a Transcriptome for the Cricket Gryllus bimaculatus (2013, NA)
• Deregulated genes upon miR-196a overexpression in keratinocytes (2013, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus,NA)
• Deregulated genes upon miR-10b overexpression in FaDu cell line (2013, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus,NA)
• Hypothetical time course of the unfolded protein response in mammals (2013, NA)
• Involvement of Cdc42, Rac1 and RhoA in vesicle trafficking, cellular transformation, invadopodia formation and metastasis (2013, NA)
• The canonical Notch signaling pathway (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Human gammaherpesvirus 8)
• Regulation of the G2/M transition in the yeast cell cycle (2013, NA)
• Transcriptome Analysis of PPARG Target Genes Reveals the Involvement of Lysyl Oxidase in Human Placental Cytotrophoblast Invasion (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Armoracia rusticana,Diaporthe sclerotioides,Brugmansia versicolor,Homo sapiens,Mus musculus)
• Signaling by innate immune receptors (2013, NA)
• An overview of signaling by the EGF family (with EGF and EGFR/ErbB1 as example) from cell surface down to the nucleus (without taking into account endocytic trafficking and recycling of the receptor) (2013, NA)
• Diacylglycerol has a central role in TCR signaling (2013, NA)
• P53 and BRCA regulation of DNA repair represents a central component of altered cellular function in serous ovarian cancer (2013, Chlamydia trachomatis,Neisseria gonorrhoeae,Mycoplasmoides genitalium,Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Signaling pathways activated by PGE2 stimulation of the human EP2 and EP4 prostanoid receptors (2013, Homo sapiens,Mus musculus,Candida dubliniensis,Dictyostelium discoideum)
• Proposed model showing molecular mechanisms of dysregulated immune pathways in diabetic renal tissues (2013, Escherichia coli,Staphylococcus aureus,Lactobacillus sp.,Staphylococcus aureus 1-B-1,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human betaherpesvirus 5)
• GSK-3 Inhibition Potentiates the Synaptogenic and Antidepressant-Like Effects of Subthreshold Doses of Ketamine (2013, Homo sapiens,Rattus norvegicus)
• Summary of the convergence of the E2–ERK and mTORC1 signaling pathways in regulating migration and invasion in LAM patient-derived cells (2013, Homo sapiens,Arabidopsis thaliana)
• Physiopathological aspects of the Wnt/Beta-catenin signaling pathway in the male reproductive system (2013, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Arachidonic acid metabolism pathway where the differential genes and metabolites of colorectal cancer were annotated (2013, Homo sapiens,Aepyceros melampus)
• Schematic description of the MSR (2013, NA)
• Cell-adhesion-dependent Beta-catenin signalling (2013, NA)
• Hypothetical evolutionary and functional relationship between Beta-catenin and nuclear transport receptors (2013, NA)
• CQ excites TRPA1 and TRPC3, sensitizes TRPV1, and inhibits TRPM8 through different signaling mechanisms (2013, NA)
• Proposed genetic networks of osseointegration (2013, NA)
• Summary of the aerobic and anaerobic cobalamin biosynthetic pathways from precorrin-2 to cobyrinic acid a,c-diamide (2013, Priestia megaterium)
• Mechanisms connecting PTEN with longevity (2013, NA)
• Cell wall integrity (CWI) signaling pathway with transcriptomic expression changes during limonene stress (2013, NA)
• Protein-protein interaction network and SPIA analysis of the 28 up-regulated genes related to positive regulation of cell proliferation and 21 down- regulated genes related to negative control of cell proliferation (2013, NA)
• TGFB and NOTCH activation in AoSMCs stimulated with P (2013, NA)
• Emerging roles of store-operated Ca2+ entry through STIM and ORAI proteins in immunity, hemostasis and cancer (2013, NA)
• The innate immune antiviral response triggered by IFNB and TNFA in AECs (2013, NA)
• Signaling pathway linking NMDA receptor activation to NOX2 superoxide production (2013, Mus musculus,Rattus norvegicus,Armoracia rusticana,Matthiola incana,Oryctolagus cuniculus,Homo sapiens)
• Working model for DR6/p75NTR receptor complex signaling in cortical neurons (2013, NA)
• Overview of the p38 MAPK pathway (2013, Homo sapiens,Mus musculus)
• Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains Beta-Cell Phenotype in Human Islets (2013, NA)
• RAS-RAF pathway and immunohistochemical staining of colorectal cancer specimens with BRAF V600E mutation specific monoclonal antibody (2013, NA)
• mTOR plays critical roles in pancreatic cancer stem cells through specific and stemness-related functions (2013, Homo sapiens,Mus musculus,Citrus macrophylla)
• Initiation of atherosclerosis by disturbed flow (2013, NA)
• Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer (2013, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pathway for Death receptor signalling at 24 h post-M (2013, Escherichia coli,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Brucella melitensis,Mycobacterium tuberculosis variant bovis AF212297,Saccharomyces cerevisiae,Sequoia sempervirens,Candida parapsilosis,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Middle East respiratory syndrome-related coronavirus)
• Proposed model for attenuation of canonical TGFB SMAD and activation of non-canonical TGF-Beta-NFKB signaling pathways in HNSCC (2013, NA)
• Hippo pathway in Drosophila (a) and mammals (b) (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Diaporthe sclerotioides,Hepatitis B virus,NA,NA)
• Interactions of stress proteins and cell surface TLR signaling pathways (2013, NA)
• Stress proteins in crosstalk with cytoplasmic PRR signaling (2013, NA)
• PRR activated signaling and antiviral responses during virus infection (2013, NA)
• Diagram representing possible mechanisms linking HCV-induced oxidative stress with hepatocarcinogenesis (2013, Homo sapiens,Mus musculus,Gallus gallus,Hepatitis C virus genotype 1,NA)
• Asperolide A on Ras/Raf/MEK/ERK signaling and G2/M cell cycle arrest (2013, Armoracia rusticana,Aspergillus wentii,Homo sapiens,Mus musculus,Bos taurus,JC polyomavirus)
• How does the metabolism of tumour cells differ from that of normal cells (2013, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,NA)
• ASC-mediated switch between pyroptosis and apoptosis: intracellular pathogens and their products lead to activation of the ASC-dependent inflammasome (2013, NA)
• Wnt pathway regulation of egl-18/elt-6 in larval seam cell fate specification (2013, Caenorhabditis elegans,Homo sapiens)
• Schematic depiction of c-Myc functional interactions with other pathways (for full discussion, see section Induction–Reversion Tumorigenesis in Animal Models by Oncogene-Driven Cancer Network Formation) (2013, Homo sapiens,Pan troglodytes,Mus musculus,Saccharomyces cerevisiae,Mouse mammary tumor virus)
• Schematic diagram of the IP3 cytoplasmic Ca2+ branch of the PLC-mediated GqPCR signaling pathway studied in (modified from Fig (2013, NA)
• The regulation and function of MYC in the androgen signaling pathway in molecular apocrine breast cancers (2013, NA)
• Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis (2013, Mus musculus,Homo sapiens)
• Metabolic pathway of the circadian rhythm for unigenes by KEGG annotation (2013, Cymbidium sinense)
• Role of Nor-1 in incretin-induced insulin expression and secretion and hypothetical localization of the TCF7L2 and NR4A3 SNP effects (2013, NA)
• Crosstalk between hedgehog signaling, Wnt/Beta-catenin signaling, notch signaling, and phosphoinositide 3 (PI3)-kinase/Akt pathway and targeting by norcantharidin (NCTD) (2013, Mus musculus,Rattus norvegicus,Cricetulus griseus,Mylabris phalerata,Lytta vesicatoria,Homo sapiens,Xenopus laevis,Paraechinus aethiopicus)
• Schematic model of the GTE-mediated antiproliferative effect on HER2-overexpressing cancer cells (2013, Ganoderma tsugae,Homo sapiens)
• Biochemical pathway proposed for 1,3-dichloroprop-1-ene biodegradation in the Gram-negative bacterium Pseudomonas pavonaceae 170 (2013, Pseudomonas pavonaceae)
• Contributions of macrophage and adipocyte TF signaling to obesity and insulin resistance (2013, NA)
• Metabolic map showing selected pathways of D (2013, Dehalobacter restrictus)
• Intracellular signaling pathways of GLP-1R in the pancreatic Beta-cell (2013, NA)
• Oncogenic and antiapoptotic functions of KSHV (2013, NA)
• Molecular mechanism of DSS-induced colitis in murine model (2013, Mus musculus,Homo sapiens)
• Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis (2013, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium leprae,Homo sapiens,Mus musculus,Ebola virus,NA)
• Galectin-3 is a regulator of metaflammation in adipose tissue and pancreatic islets (2013, NA)
• Schematic illustrating the signaling pathways for TGFB1-induced down-regulation of VE-cadherin and the inhibition of cell invasion in human trophoblast cells (2013, Homo sapiens)
• The p53-mediated apoptotic signaling pathways (2013, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Saccharomyces cerevisiae VL3,Homo sapiens,Mus musculus,Danio rerio,prion,Bacillus anthracis)
• MicroRNAs regulating myogenesis via PI3K/Akt signaling (2013, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Solanum lycopersicum,Diaporthe sclerotioides,Homo sapiens,Bos taurus,Caenorhabditis elegans)
• Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis (2013, NA)
• Reduction of In-Stent Restenosis Risk on Nickel-Free Stainless Steel by Regulating Cell Apoptosis and Cell Cycle (2013, Homo sapiens,Bos taurus)
• Interferon beta signaling pathway (2013, Homo sapiens,Allium cepa,Human alphaherpesvirus 3)
• Schematic model of Akt and ERK activation and hypertrophy through miR-200b/c and FOG2 pathway in response to TGFB in the pathogenesis of diabetic nephropathy (2013, Mus musculus,Homo sapiens)
• STAT3-mediated coincidence detection regulates a noncanonical pathway of IEG induction (2013, NA)
• Proposed roles of VID28 in the Vid pathway (2013, NA)
• PI3K signaling pathway and the downstream targets of Akt (2013, Mus musculus,Cricetulus griseus,Homo sapiens,Canis lupus familiaris,Streptomyces hygroscopicus)
• Beta-Adrenergic receptors potentiate glutamate release at cerebrocortical nerve terminals (2013, NA)
• Wnt3a binds to Fz7 and cross-activate the IGF-1-PI3k-Akt pathway inducing initial axonal outgrowth and neuronal polarization (2013, NA)
• Key reactions involved in the sphingolipid metabolic pathway (2013, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Embryophyta,Homo sapiens,Drosophila melanogaster)
• Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFA Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells (2013, Escherichia coli,Listeria monocytogenes,Escherichia coli DH5alpha,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Parthenocissus quinquefolia)
• The VEGF-DLL4-Notch signaling pathway in angiogenic sprouts (2013, Homo sapiens,Mus musculus,Danio rerio)
• Incretin-induced cAMP signaling in the pancreatic Beta-cell (2013, NA)
• mTOR pathway signaling cascade (2013, NA)
• Sirt1 Inhibits Akt2-Mediated Porcine Adipogenesis Potentially by Direct Protein-Protein Interaction (2013, NA)
• Application of Artificial Neural Networks to Investigate One-Carbon Metabolism in Alzheimer’s Disease and Healthy Matched Individuals (2013, Homo sapiens,Mus musculus,Gallirallus australis)
• Cellular responses to a DSB in S (2013, NA)
• Retinoid action during paramyxovirus infection (2013, Human immunodeficiency virus 1,Human immunodeficiency virus,Human papillomavirus,Respiratory syncytial virus,Human gammaherpesvirus 8,Measles morbillivirus,Dengue virus type 3,Phocine morbillivirus,Canis lupus familiaris,Mustela putorius furo,Bison bonasus,Homo sapiens,Mus musculus,Gallus gallus,NA,NA,NA,NA)
• Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague (2013, Yersinia pestis,Homo sapiens)
• HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1 (2013, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Respiratory syncytial virus,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,Measles morbillivirus,Enterovirus A71,Non-A non-B hepatitis virus,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus,Oryza sativa,Helicobacter pylori,Cryptosporidium parvum,NA,NA)
• Phosphatidylinositol 5-phosphate is a second messenger important for cell migration (2013, NA)
• Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways (2013, Mus musculus,gut metagenome,Homo sapiens)
• CCDC22 deficiency in humans blunts activation of proinflammatory NFKB signaling (2013, NA)
• Differentiation of progenitors in the liver: a matter of local choice (2013, NA)
• Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms (2013, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Campylobacter jejuni,Citrobacter rodentium,Mycobacterium avium,Clostridioides difficile CD3,Candidatus Sodalis pierantonius str. SOPE,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Aspergillus fumigatus,Coxsackievirus,Entamoeba histolytica,Derris trifoliata,unidentified virus,Homo sapiens,Canis lupus familiaris)
• A three-stage pathway for tau-dependent cell cycle re-entry induced by AB1–42 oligomers (2013, NA)
• PPARG transduction pathway (2013, Homo sapiens)
• Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes (2013, Homo sapiens,Mus musculus,Candida pruni nom. inval.)
• Transcriptome Analysis of Skin Photoaging in Chinese Females Reveals the Involvement of Skin Homeostasis and Metabolic Changes (2013, Homo sapiens,Mus musculus,Candida pruni nom. inval.)
• Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2 (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens)
• The RhoGEF2 effector pathway required for cooperation with RasACT in tumorigenesis (2013, Oryctolagus cuniculus,Capra hircus,Malus domestica,Matthiola incana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Model showing the proposed mechanisms of lncRNA-mediated regulation of the RB pathway (2013, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Mechanisms underlying the late-phase of CF elimination (2013, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Olea europaea,Mustela putorius furo)
• CTLRs within the Dectin-1 cluster that contain novel signaling motifs (2013, Saccharomyces cerevisiae,Candida albicans,Candida albicans 23P,Mus musculus,Rattus norvegicus,Escherichia coli,Human immunodeficiency virus 1,Mycobacterium tuberculosis,DNA viruses,Homo sapiens)
• ITIM-bearing CTLRs within the Dectin-1 cluster (2013, Saccharomyces cerevisiae,Candida albicans,Candida albicans 23P,Mus musculus,Rattus norvegicus,Escherichia coli,Human immunodeficiency virus 1,Mycobacterium tuberculosis,DNA viruses,Homo sapiens)
• ITAM-like-bearing CTLRs within the Dectin-1 cluster (2013, Saccharomyces cerevisiae,Candida albicans,Candida albicans 23P,Mus musculus,Rattus norvegicus,Escherichia coli,Human immunodeficiency virus 1,Mycobacterium tuberculosis,DNA viruses,Homo sapiens)
• Signaling network of Dectin-1 (2013, Saccharomyces cerevisiae,Candida albicans,Candida albicans 23P,Mus musculus,Rattus norvegicus,Escherichia coli,Human immunodeficiency virus 1,Mycobacterium tuberculosis,DNA viruses,Homo sapiens)
• Calcium and strontium induce distinct intracelular calcium signaling (2013, NA)
• FGF signalling cascade in Drosophila melanogaster (2013, Drosophila melanogaster,Homo sapiens)
• Signaling pathways involved in thrombin induced EMP formation (2013, NA)
• MAP kinase signaling pathway of sugarcane infected by S (2013, NA)
• StarD7 in various cellular events in JEG-3 cells (2013, NA)
• Steroidogenic factor 1 (SF-1)/Beta-catenin upregulates StarD7 expression in JEG-3 cells (2013, NA)
• Mitochondrial apoptotic pathway involving p53 and ceramide in response to stress: Ceramide activates protein phosphatase 2A (PP2A) which dephosphorylates Bcl-2 and inhibits its antiapoptotic activity (2013, Saccharomyces cerevisiae,Malus domestica,Schizosaccharomyces pombe,Kluyveromyces lactis,Saccharomyces cerevisiae SK1,Ficus mucuso,Human papillomavirus,Human T-cell leukemia virus type I,Kappapapillomavirus 2,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Danio rerio)
• Flotillins are novel scaffolding proteins for the ERK/MAPK pathway (2013, NA)
• Scheme illustrating potential mechanisms by which nandrolone reduces bone loss after SCI (2013, Homo sapiens,Rattus norvegicus)
• The role of K+ channels during cell cycle progression and proliferation (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Xenopus laevis)
• Summary diagram of the proposed mechanisms underlying CA3 hypersensitivity, Alzheimer’s disease protein induction, neuronal death and behavioural deficits following cerebral ischaemia in rats with LTED (2013, Homo sapiens,Rattus norvegicus)
• The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders (2013, NA)
• TNFR1 signaling of cell survival/proinflammatory and apoptosis pathways. Upon TNF receptor activation, complexes I (survival pathway) and II (apoptosis) are formed (2013, NA)
• Expected intracellular signal pathways of LPA-induced contraction in esophageal smooth muscle cell (2013, NA)
• Gene Expression Variability in Human Hepatic Drug Metabolizing Enzymes and Transporters (2013, NA)
• Interferon-Beta Induces Distinct Gene Expression Response Patterns in Human Monocytes versus T cells (2013, Homo sapiens,Bos taurus,Drosophila melanogaster,Canis lupus familiaris,Gorilla gorilla,Anisakis simplex,Mus musculus,Dengue virus,Sequoia sempervirens)
• Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns (2013, Dengue virus,Respiratory syncytial virus,West Nile virus,Japanese encephalitis virus,Reovirus sp.,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Candida dubliniensis,Borreliella burgdorferi,Homo sapiens,Mus musculus,NA)
• Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns (2013, Dengue virus,Respiratory syncytial virus,West Nile virus,Japanese encephalitis virus,Reovirus sp.,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Candida dubliniensis,Borreliella burgdorferi,Homo sapiens,Mus musculus,NA)
• Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns (2013, Dengue virus,Respiratory syncytial virus,West Nile virus,Japanese encephalitis virus,Reovirus sp.,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Candida dubliniensis,Borreliella burgdorferi,Homo sapiens,Mus musculus,NA)
• Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns (2013, Dengue virus,Respiratory syncytial virus,West Nile virus,Japanese encephalitis virus,Reovirus sp.,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Candida dubliniensis,Borreliella burgdorferi,Homo sapiens,Mus musculus,NA)
• Decreased Pattern Recognition Receptor Signaling, Interferon-Signature, and Bactericidal/Permeability-Increasing Protein Gene Expression in Cord Blood of Term Low Birth Weight Human Newborns (2013, Dengue virus,Respiratory syncytial virus,West Nile virus,Japanese encephalitis virus,Reovirus sp.,Escherichia coli,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Candida dubliniensis,Borreliella burgdorferi,Homo sapiens,Mus musculus,NA)
• The roles of mTORC1 and mTORC2 in pulmonary vascular remodeling (2013, NA)
• MTOR signaling pathway (2013, NA)
• MicroRNA-34a Mediates the Autocrine Signaling of PAR2-Activating Proteinase and Its Role in Colonic Cancer Cell Proliferation (2013, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth (2013, NA)
• Alternative pathway (2013, Homo sapiens)
• IL-6 Regulates Mcl-1L Expression through the JAK/PI3K/Akt/CREB Signaling Pathway in Hepatocytes: Implication of an Anti-Apoptotic Role during Liver Regeneration (2013, Mus musculus,Rattus norvegicus,Bos taurus,Equus asinus x Equus caballus,Homo sapiens,Gallus gallus)
• Graphical representation of Wnt pathway as described in the KEGG repository () (2013, NA)
• Comparative Transcriptional Profiling of 3 Murine Models of SLE Nephritis Reveals Both Unique and Shared Regulatory Networks (2013, NA)
• Hypothetical schematic signaling pathway of SCRT-induced membrane depolarizations on ICCs (2013, NA)
• PKM2 activity is controlled by a tight regulatory network at the transcriptional, proteomic and metabolic level (2013, NA)
• Diabetes mellitus induced regulation of skeletal muscle (2013, NA)
• Summary of the proposed role of Pak1 in mediating stretch-induced CTGF upregulation (2013, NA)
• Scheme of the proposed LIF signaling pathway in trophoblasts (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Human gammaherpesvirus 4)
• Diabetes mellitus induced regulation of osteoclast (2013, NA)
• Scheme represents an epigenetic mechanism that abnormal activity of histone H3K9-specific methyltransferase (ESET) leads to synaptic failure and striatal dysfunction in Huntingdon’s disease (HD) (2013, NA)
• Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain (2013, NA)
• RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats (2013, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Escherichia coli,Candida dubliniensis,Hepatitis B virus)
• RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats (2013, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Homo sapiens,Escherichia coli,Candida dubliniensis,Hepatitis B virus)
• Schematic model of GMIP and Slp1/JFC1 regulation of vesicular dynamics and exocytosis in neutrophils (2013, NA)
• Essential TLR-associated signaling pathways and cytokine production (2013, NA)
• DA receptor signaling pathways activated in response to seizures (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic representation of p30 functions (2013, Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Human T-lymphotropic virus 2,Homo sapiens,Oryctolagus cuniculus)
• Signaling modules responsible for autophagy-lysosome pathway in the adult (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain (2013, NA)
• Schematic illustration for the different targets or pathways involved in the antidepressant-like effect of T (2013, NA)
• Shared network structure by non-small lung cancer pathway in KEGG and reconstructed co-expression networks using the CCA and GLASSO methods (2013, NA)
• The process of LC3-associated phagocytosis (LAP) (2013, NA)
• Interleukin 6 signaling scheme of the interleukin 6/signal transducer and activator of transcription 3 signaling pathway (2013, NA)
• Schematic summary of OPRM1 differential signal pathways upon acute and chronic morphine administration (2013, NA)
• Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats (2013, Isostichopus badionotus,Homo sapiens)
• Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats (2013, Isostichopus badionotus,Homo sapiens)
• Signaling modules that are important therapeutic targets to counteract muscle wasting (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation (2013, NA)
• Regulation of hepatic hepcidin induction at the cellular level (2013, Mus musculus,Rattus norvegicus,Glycine max,Candida albicans,Homo sapiens,Danio rerio,Human immunodeficiency virus,Brucella abortus)
• A Protein Prioritization Approach Tailored for the FA/BRCA Pathway (2013, NA)
• Expression of Glyceraldehyde-3-Phosphate Dehydrogenase Associated Cell Cycle (GACC) Genes Correlates with Cancer Stage and Poor Survival in Patients with Solid Tumors (2013, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Alternative splicing regulation of the Ras-MAPK pathway (2013, NA)
• Alternative splicing regulation of the PI3K-mTOR pathway (2013, NA)
• Yeast Ras/PKA pathway (2013, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Epithelial cancer cell invasiveness and sensitivity mediated by K8/18 loss (2013, NA)
• SLP-76–dependent signaling pathways in NK cells stimulated through ITAM-bearing receptors (2013, Mus musculus,Homo sapiens)
• "Cell Death and Survival, Cell Cycle, Cell-to-Cell Signaling and Interaction, Cellular Movement" Network (2013, NA)
• Highest-scoring downregulated network: Energy Production, Metabolism and Cell Structure (2013, Rattus norvegicus,Homo sapiens)
• "Cancer, Hematological Disease, Cell Cycle" Network (2013, NA)
• Ingenity Pathway Analysis (IPA) from genes with loss of heterozygosity and somatic mutation (sample G05) (2013, NA)
• Regulators of mitochondrial biogenesis and function (2013, NA)
• The two possible pathways by which MUC1 regulates MRP1 gene expression in PC cells (2013, Mus musculus,Rattus norvegicus,Cricetulus migratorius,Homo sapiens,Bikinia letestui)
• B-cell receptor (BCR) signaling pathway and potential targets (2013, NA)
• Oleic acid signaling in human renal cell carcinoma (RCC) (2013, NA)
• De-Regulated MicroRNAs in Pediatric Cancer Stem Cells Target Pathways Involved in Cell Proliferation, Cell Cycle and Development (2013, Homo sapiens,Mus musculus,Bos taurus)
• FXR/NR1H4 gene (2013, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Pseudomonas aeruginosa,Turdus migratorius)
• Proposed action pathway of genistein to regulate insulin IRS1/Akt signalling in adipose tissue (2013, Mus musculus,Glycine max,Homo sapiens)
• Shear stress reveals the mechanisms by which OA induces PICs and MMPs in human chondrocytes (2013, NA)
• Networks of shear stress-induced OA progression (2013, NA)
• New signaling network for melanoma (2013, NA)
• Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• BDNF-activated tropomyosin-related kinase B (TrkB) signal transduction (2013, NA)
• The novel NRP2A6B1-FAK-RAS-GLI1 axis involved in the regulation of tumour initiating cells in breast cancer (2013, Homo sapiens,Mus musculus)
• Proposed model suggesting that TGFB increases COX-2 levels and PGE2 secretion in prostate cancer cells and both TGFB and PGE2 activate PI3K/AKT/mTOR signaling pathway (2013, NA)
• Proposed roles of Msi1-like (MSIL) proteins as regulators of the nutrient- and stress-sensing signaling pathways in fungi (2013, NA)
• PI3K/PTEN/Akt pathway (2013, Homo sapiens,Mus musculus)
• Diabetes mellitus induced regulation of osteoblast (2013, NA)
• Non-Invasive Imaging of Tumors by Monitoring Autotaxin Activity Using an Enzyme-Activated Near-Infrared Fluorogenic Substrate (2013, Homo sapiens,Chlorocebus aethiops,Mus musculus,Bos taurus)
• Oncometabolites: linking altered metabolism with cancer (2013, NA)
• Subcellular distribution of the antioxidant network in T (2013, NA)
• Factors situated at the interface between the ubiquitin-proteasome and the autophagy-lysosome degradative systems (2013, NA)
• Integrated view of mammalian autophagy (2013, NA)
• Arsenic affects NRF2 signaling pathway (2013, NA)
• Arsenic-mediated disruption of PI3K/AKT signaling pathway (2013, NA)
• Arsenic-mediated activation of EGFR signaling pathway (2013, NA)
• Original model by Neumann et al (2013, Homo sapiens,Melpomene michaelis)
• Role of the eIF2A/ATF4 signaling pathway in the transcriptional activation of autophagy genes (2013, NA)
• Molecular and biochemical studies in hyperlysinemia patients (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Pathway analysis showing integration between signaling pathways, transcription factors, and adhesion genes (2013, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Schematic model depicting the proposed signaling pathway in LH/hCG-induced miR-122-mediated LHR mRNA down-regulation (2013, Homo sapiens,Rattus norvegicus)
• Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells (2013, Homo sapiens,Escherichia coli,Dictyostelium discoideum,Triturus cristatus)
• The possible molecular mechanisms of pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis in rats (2013, Lareunionomyces loeiensis,Punica granatum,Azadirachta indica,Ribes nigrum,Mus musculus,Rattus norvegicus,Hepatitis B virus,Hepatitis C virus genotype 4,Homo sapiens,Oryctolagus cuniculus,NA)
• Neuroactive ligand-receptor interaction and calcium signaling pathway (2013, NA)
• Molecular network analysis of the miR-200 family and potential molecular targets with Ingenuity pathway analysis (IPA) (2013, NA)
• IPA-generated gene network linking 88 of 445 genes shown by microarray analysis to be significantly (P < 0.01) up- (blue) or down- (red) regulated >twofold in bovine TCs in response to BMP6 treatment (2013, Homo sapiens,Bos taurus)
• Gene network associated with IFN pathway signaling (2013, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Zea mays,Scapteromys aquaticus,Prunus spinosa,Escherichia coli,Escherichia coli O6H16CFAII str. B2C,Homo sapiens)
• Ribosome Synthesis and MAPK Activity Modulate Ionizing Radiation-Induced Germ Cell Apoptosis in Caenorhabditis elegans (2013, Caenorhabditis elegans,Homo sapiens)
• Targeting the PI3K and BTK pathways in NHL (2013, Homo sapiens,Mus musculus,Oryza sativa)
• Interferon (IFN)-Gamma-activated pronecrotic and prosurvival signaling pathways (2013, NA)
• Eliminative signaling by IFN1 (2013, NA)
• PI3-K signaling.Notes: Activation of class I PI3-K via RTK phosphorylates and activates downstream target PDK1, in turn phosphorylating AKT kinases at the threonine site (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Mouse mammary tumor virus)
• Schematic view of kallistatin action in the canonical Wnt pathway (2013, NA)
• Oncogenes and tumor suppressor modulate metabolic reprograming in cancer cells (2013, NA)
• Function of miR-375 in the CRF-enhanced POMC signaling pathway (2013, Mus musculus,Homo sapiens)
• A diverse range of signaling pathways that can lead to persistent PKC activation to support cell migration (2013, Homo sapiens,Mus musculus)
• Comparative analysis of NOTCH signaling pathway components in calcium-differentiated 8E6-iHFKs and GSI-treated C-HFKs by qRT-PCR (2013, NA)
• Downregulation of human NK cell-mediated cytotoxicity pathway genes in response to Gal-9 (2013, NA)
• Gab2 signaling and its negative regulation by RSK (2013, Homo sapiens,Mus musculus)
• Simplified version of the mTOR signalling pathway (2013, Homo sapiens,Mus musculus)
• Nutrigenomics in Arma chinensis: Transcriptome Analysis of Arma chinensis Fed on Artificial Diet and Chinese Oak Silk Moth Antheraea pernyi Pupae (2013, NA)
• Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells (2013, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Francisella tularensis subsp. novicida,Homo sapiens,Mus musculus,Candida albicans,vectors,Mustela putorius furo)
• NAC protects against Cd-induced germ cell apoptosis by inhibiting UPR signalling in the testes (2013, NA)
• Toll-like receptor signaling in liver cells (2013, NA)
• Fructose metabolic pathway in L (2013, NA)
• Mass isotopomer labeling measurements of intracellular metabolites (red bars, after 8.0 h in growth phase I; green bars, after 14.25 h in growth phase II) arranged by pathways: fractional abundance over mass in context of the metabolic network (2013, Gluconobacter oxydans,Gluconobacter oxydans 621H)
• Four proposed pathways for propionyl-CoA synthesis in H (2013, NA)
• THF and 1,4-dioxane degradation pathways (2013, NA)
• Proposed mechanisms underlying sildenafil neuroprotection against malonate-induced neurotoxicity (2013, Rattus norvegicus,Homo sapiens)
• Key signaling pathways modulated by WNV infection (2013, NA)
• Labeling patterns in end products and pathway intermediates derived from the metabolism of [1-13C], [2-13C], and/or [3-13C]Glc in B (2013, NA)
• The mevalonate pathway in Schistosoma mansoni (2013, NA)
• Identification and Functional Analysis of Trypanosoma cruzi Genes That Encode Proteins of the Glycosylphosphatidylinositol Biosynthetic Pathway (2013, NA)
• Intracellular S100B on cell proliferation, differentiation, survival and motility (2013, NA)
• RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases (2013, NA)
• Regulation of HDL homeostasis by miRNAs (2013, NA)
• Established and putative signaling pathways coupled to KISS1R (2013, NA)
• 380 kb pCMU01 Plasmid Encodes Chloromethane Utilization Genes and Redundant Genes for Vitamin B12- and Tetrahydrofolate-Dependent Chloromethane Metabolism in Methylobacterium extorquens CM4: A Proteomic and Bioinformatics Study (2013, NA)
• Hypothetical MEND pathway (2013, NA)
• Proposed mechanism for the role of Notch signaling pathway activation to mediate STAT3 phosphorylation-dependent survivin upregulation during recovery from AKI (2013, NA)
• Molecular mechanisms of Notch-mediated epidermal homeostasis (2013, NA)
• Involvement of mutant p53 in lamellipodium dynamics and cell migration (2013, NA)
• Our proposed model for two distinct pathways in ICL-induced ATR signaling (2013, NA)
• Targeted therapy pathways.Notes: Protein kinase B (AKT) is a serine/threonine-specific protein kinase that affects glucose metabolism, apoptosis, cell proliferation, transcription and cell migration (2013, Homo sapiens)
• Mammalian target of rapamycin (mTOR) -centric view of nutrient sensing for the induction of forkhead box P3 (FOXP3) (2013, Homo sapiens)
• Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response (2013, NA)
• Proposed role of aPKCs in synaptic plasticity: At most CNS synapses, strong synaptic input leads to an activation of PI3K signaling and PDK1 activation thereby (1) thereby leading to mTORC1 activation (2013, Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans,Diaporthe sclerotioides,Lambdavirus lambda)
• Enzymes that catabolize or use essential amino acids (2013, Homo sapiens)
• Accumulation of monocytes/macrophages in adipose tissue and liver, and activation in the tissues (2013, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• RNAi Mediated Tiam1 Gene Knockdown Inhibits Invasion of Retinoblastoma (2013, NA)
• MTX cellular pathway (2013, NA)
• HTLV-1 and apoptotic signaling pathways (2013, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Human papillomavirus types,Hepatovirus A,human papillomavirus 11,Human endogenous retrovirus,Human betapapillomavirus,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Helicobacter pylori,Turdus migratorius,NA,NA,NA)
• Downregulated network of CANB1 in traumatic brain injury (TBI) (2013, Rattus norvegicus,Homo sapiens)
• Causes and consequences of mTOR activation in the brain (2013, Homo sapiens,Mus musculus)
• Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß (2013, Homo sapiens,Mus musculus,Bos taurus,Mouse mammary tumor virus,Sequoia sempervirens)
• Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß (2013, Homo sapiens,Mus musculus,Bos taurus,Mouse mammary tumor virus,Sequoia sempervirens)
• Regulating small G protein signaling to coordinate axon adhesion and repulsion (2013, NA)
• Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles (2013, NA)
• Hypothetical scheme shows the inhibitory signaling of andrographolide in platelet activation (2013, NA)
• Cyclooxygenase pathway (2013, NA)
• Schematic summary of the most common mutations found in melanoma patients (2013, NA)
• HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations (2013, Homo sapiens)
• Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway (2013, NA)
• Summary of proposed pathway leading from TGFB1 receptor binding to ROS generation (2013, NA)
• Proposed model for how GIV’s GEF function is regulated by PKCθ (2013, NA)
• Gonadotropin-releasing hormone (GnRH) signaling pathway containing genes that are represented in the Partial Correlation Information Theory (PCIT) network “growth at the onset of puberty” (2013, NA)
• Proposed reactive oxygen species (ROS)-dependent signaling pathways for serotonin (5-HT)-induced GATA4 activation in pulmonary artery smooth muscle cells (2013, Homo sapiens)
• Non-targeted responses in the out of field lung tissues after lower abdomen irradiation (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Dipturus trachyderma)
• Computational Model of Lipopolysaccharide-Induced Nuclear Factor Kappa B Activation: A Key Signalling Pathway in Infection-Induced Preterm Labour (2013, Homo sapiens,Mus musculus)
• Various signaling pathways promoting or inhibiting inflammatory signaling (green arrows represent activation, and red arrows represent inhibition) (2013, Homo sapiens,Mus musculus)
• Lycopene inhibits theWnt/Beta-catenin pathway (2013, Nicotiana tabacum,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Allium sativum,Citrus x paradisi,Melia azedarach,Carica papaya,Citrullus lanatus subsp. vulgaris,Prunus armeniaca,Psidium guajava,Serenoa repens,Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Homo sapiens,Canis lupus familiaris)
• Lycopene induces cell-cycle arrest and apoptosis (2013, Nicotiana tabacum,Glycine max,Solanum lycopersicum,Diaporthe sclerotioides,Allium sativum,Citrus x paradisi,Melia azedarach,Carica papaya,Citrullus lanatus subsp. vulgaris,Prunus armeniaca,Psidium guajava,Serenoa repens,Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Homo sapiens,Canis lupus familiaris)
• Representative ingenuity pathway analysis (IPA) of relationship between significant genes involved in the response to mechanical stretch and/or BIRB796 treatment in engineered cardiac tissues (2013, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Bos taurus,Sequoia sempervirens)
• WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,murine stem cell retroviral vector)
• Contradictory KRAS mutation test results in a patient with metastatic colon cancer (2013, NA)
• Off-label use of cetuximab plus sorafenib and panitumumab plus regorafenib to personalize therapy for a patient with V600E BRAF-mutant metastatic colon cancer (2013, Homo sapiens)
• FOLFIRI plus dulanermin (rhApo2L/TRAIL) in a patient with BRAF-mutant metastatic colon cancer (2013, NA)
• Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells (2013, Homo sapiens)
• Proposed signaling pathway model for VEGF-A signaling in hypoxia-stressed BM-EPCs compiled from the proteomic and gene expression analysis is highlighted here (2013, Rattus norvegicus,Homo sapiens)
• Predicted upstream regulators inhibited in DA rats but activated in congenics (2013, Rattus norvegicus,Homo sapiens)
• Simplified Model of the Discussed Mechanical Signaling Networks in Self-Organizing Pollen Tube Growth.For better-elucidated signaling modules, feedback regulations and pathway crosstalks are common (2013, NA)
• Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy (2013, NA)
• Mutations in the ERK/MAPK signaling pathway and related second messenger systems (2013, NA)
• Associated intracellular cascades to physiopathology of vascular remodeling (2013, Homo sapiens,Rattus norvegicus)
• Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats (2013, NA)
• Simplified schematic representation of the insulin and TOR signaling pathways as they have been described in mammals and for which orthologous components have been described in D (2013, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Manduca sexta,Tribolium castaneum,Ciona intestinalis,Spodoptera frugiperda,Rhodnius prolixus,Glossina morsitans,Tenebrio molitor,Culex pipiens,Blattella germanica,Locusta migratoria,Schistocerca gregaria,Solenopsis invicta,Sarcophaga bullata,Phormia regina,Onthophagus acuminatus,Onthophagus nigriventris,Melanoplus sanguinipes,Romalea microptera,Saccharomyces cerevisiae,Agaricus bisporus,Homo sapiens,Rattus norvegicus,Bos taurus)
• Characterization of CP genes in relation to the canonical TGFB signaling pathway (2013, NA)
• Influence of hepatocyte culture conditions on signaling and phenotype (2013, NA)
• Proposed model of mTOR myogenic signaling (2013, Bos taurus,Oryctolagus cuniculus,Equus caballus,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Mus musculus)
• combination drug simulation result on T2D model (2013, NA)
• Single drug simulation result on T2D model (2013, NA)
• Tryptophan metabolic pathway (2013, NA)
• Pharmacologic Inhibition of CXCL10 in Combination with Anti-malarial Therapy Eliminates Mortality Associated with Murine Model of Cerebral Malaria (2013, NA)
• Schematic model of potential silibinin effects on the Cdk4 pathway in controlling tumor formation (2013, NA)
• Biomarker-guided translation of brain imaging into disease pathway models (2013, NA)
• Causal role for JAK2 V617F in thrombosis (2013, NA)
• Mechanism of myosin II–mediated release of microparticles from endothelial cells activated by antiB2GPI antibodies (2013, NA)
• The PI3K pathway is the evolutionary conserved signalling pathway to ensure that growth and development is synchronised to the appropriate metabolic conditions: energy and substrate requiring processes only proceed when a ‘fed state’ is indicated (2013, NA)
• The PI3K signaling pathway (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• CLL-induced Rho GTPase signaling defects in T cells that suppress LFA-1 activation signaling and migration and how this is reversible with lenalidomide (2013, Homo sapiens)
• Pathomechanisms of LN outside the kidney (2013, NA)
• Multivalency and conditional regulation at the cell surface (2013, Mus musculus,Homo sapiens)
• Apoptotic signaling pathways (2013, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Human papillomavirus types,Hepatovirus A,human papillomavirus 11,Human endogenous retrovirus,Human betapapillomavirus,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Helicobacter pylori,Turdus migratorius,NA,NA,NA)
• The proposed pathways that regulate astroglial CNTF (2013, NA)
• Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps (2013, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Drosophila melanogaster,Drosophila pseudoobscura,Homo sapiens)
• Schematic of the NRG-1/ErbB pathway in the normal and diabetic heart (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Treponema medium)
• Hypothetical estrogen signaling pathways in human cerebral vascular endothelial cells (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Rattus norvegicus,Betapolyomavirus macacae)
• Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB (2013, NA)
• Proposed model for iAs-induced birth defects via the GR pathway (2013, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Bos taurus,Sequoia sempervirens)
• Possible role of non-canonical Wnt/Ca2+ pathway in mitochondrial dynamics (2013, NA)
• Changes in the genes and processes related to mitochondrial metabolism in RAW264.7 and TGEM cells treated with KLA (2013, NA)
• Role of Helicase-Like Transcription Factor (Hltf) in the G2/M Transition and Apoptosis in Brain (2013, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mustela lutreola,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,Human immunodeficiency virus 1,unidentified)
• TNFA regulates synaptic loss, synaptic transmission, and plasticity (2013, NA)
• Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses (2013, Homo sapiens,Rattus norvegicus,Gallus gallus)
• Summary of oxidative stress triggers and HO-1 related cellular responses (2013, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Enterococcus faecalis,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Pieris brassicae)
• Comparison of the gene expression and eicosanoid metabolite changes in RAW264.7 (RAW) and TGEM cells treated with KLA is shown for the arachidonic acid metabolism pathway (2013, NA)
• MicroRNA-301a Mediated Regulation of Kv4.2 in Diabetes: Identification of Key Modulators (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Developmental data alters disease mechanism prediction (2013, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Process flow diagram of signaling pathway (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Antarctothoa delta)
• Action of 20-HETE.Notes: Mitogens and ligands of G-protein-coupled receptors activate PLA2 and induce release of arachidonic acid, which is converted by CYP4A/F to 20-HETE (2013, NA)
• Summary of anti-inflammatory roles of BSNXD in atherosclerosis (2013, herbal medicine,Homo sapiens)
• CYP2E1-mediated ROS production by ethanol, followed by activation of PKCζ/JNK/SP1 pathway for the expression of CYP2E1 (red) (2013, NA)
• Comparison of gene expression in RAW264.7 (RAW) and TGEM cells treated with KLA for the TLR4 signaling pathway (2013, NA)
• Metacore™ apoptosis signaling pathway relating to TNF receptors, NFkB and BCL-2 antiapoptotic family genes (2013, NA)
• Self-renewal and differentiation of gastric stem cells (2013, NA)
• Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction (2013, NA)
• Metacore™ apoptosis signaling pathway relating to mitochondrial proteins (2013, NA)
• Metacore™ apoptosis signaling pathway relating to caspase activation (2013, NA)
• Defining mitochondrial dynamics (2013, NA)
• Mitophagy pathways (2013, NA)
• Feed-forward regulation of NOX-1 expression in beta cells (2013, NA)
• Graft-versus-host disease signaling pathway and miRNA interactions obtained using IPA (2013, Homo sapiens,Mus musculus,NA)
• N-glycoprotein biosynthesis in mammals (2013, Mus musculus,Homo sapiens)
• Regulation of AKT signalling activation (2013, NA)
• P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death (2013, NA)
• IGF-1R as an anti-cancer target—trials and tribulations (2013, Diaporthe sclerotioides,Larrea tridentata,Larrea divaricata,Homo sapiens,Rana aurora,Trithemis aurora)
• Targeting the PI3K-AKT-mTOR signaling network in cancer (2013, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of mammalian target of rapamycin (mTOR) by the LKB1/AMPK signaling pathway (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Wnt/Beta-catenin signaling pathway (2013, NA)
• Signal pathways related with cancer stem cells (2013, NA)
• Mechanisms of resistance to PI3K-mTOR inhibitors in human cancer (2013, NA)
• Transcriptional Corepressors HIPK1 and HIPK2 Control Angiogenesis Via TGFB–TAK1–Dependent Mechanism (2013, NA)
• Signaling cascade of JAK-STAT pathway (2013, NA)
• Desmoglein-1, differentiation, and disease (2013, Homo sapiens)
• Maternal factors required for oocyte developmental competence in mice (2013, NA)
• Proposed model of regulation of pro-apoptotic signaling pathway by miR-128 (2013, NA)
• The proposed therapeutic mechanism of caspase-7 ablation in ADRP T17M RHO retinas (2013, Mus musculus,Rattus norvegicus,Arachis hypogaea,Prenanthella exigua,Homo sapiens)
• Hedgehog pathway (2013, NA)
• Intra-Tumoral Heterogeneity in Metastatic Potential and Survival Signaling between Iso-Clonal HCT116 and HCT116b Human Colon Carcinoma Cell Lines (2013, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Diaporthe sclerotioides)
• Signalling pathways involved in airway smooth muscle contraction (2013, NA)
• Pathway scheme of baicalein on the cell proliferation inhibition and cell metastasis inhibition in human bladder cancer cell 5637 (2013, NA)
• Nucleotide excision DNA repair pathway as a therapeutic target in patients with high-risk diffuse large B cell lymphoma (2013, Homo sapiens)
• MicroRNA induced by FSH at spermiogenesis (2013, Mus musculus,Rattus norvegicus,Cricetus cricetus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Equus caballus)
• Signaling and transcriptional regulation of Th17 polarization (2013, NA)
• Pathways affected in monogenic hypertensive disease (2013, NA)
• Hierarchical scaffolding by caveolin-1 and IQGAP1 (2013, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Graphical representation of Ingenuity Pathway Analysis results showing considerable overlap of the significantpredictor genes in the significant biologic pathways (2013, NA)
• Graphical representation of Ingenuity Pathway Analysis results showing significant predictor genes in ‘InflammatoryResponse, Cell Death, Infection Mechanism’ pathway (2013, NA)
• Phosphorylation of ASPP2 by RAS/MAPK Pathway Is Critical for Its Full Pro-Apoptotic Function (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Armoracia rusticana,Hepatitis B virus)
• Lines/LINS plays a putative dual role in WNT canonical pathway (2013, NA)
• Graphical representation of Ingenuity Pathway Analysis results showing significant predictors genes in ‘Gene Expression, Cell Cycle, Cancer’ pathway (2013, NA)
• Mechanism of activation and inhibition of Janus kinases and signal transducer and activator transcription (JAK/STAT) pathway (2013, Homo sapiens)
• Transcriptome-Wide Mapping of Pea Seed Ageing Reveals a Pivotal Role for Genes Related to Oxidative Stress and Programmed Cell Death (2013, NA)
• Working model for the anti-HCC effect of PCAF and downstream pathway (2013, NA)
• Functions of the proteins encoded by the genes mutated in primary lymphedema cluster around a central molecular pathway: the VEGFR3 signaling (2013, NA)
• LKB1-SIK2/3-class IIa HDAC pathway as a novel signaling module (2013, NA)
• Statistical Analysis Reveals Co-Expression Patterns of Many Pairs of Genes in Yeast Are Jointly Regulated by Interacting Loci (2013, NA)
• Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII (2013, Caenorhabditis elegans,Plasmodium falciparum,Trypanosoma brucei,Schistosoma mansoni,Schistosoma japonicum,Ascaris suum,Haemonchus contortus,Ancylostoma caninum,Anisakis simplex,Mus musculus,Rattus norvegicus,Bos taurus,Mustela putorius furo,Homo sapiens,Saccharomyces cerevisiae)
• Schematic illustration of the correlation in mechanisms among detected parameters (2013, NA)
• Combining DC vaccination with immune checkpoint blockade (2013, Homo sapiens,Mus musculus,NA)
• Simplified diagram of putative signaling pathways accountable for the differential responses of tumor cells to a dual PI3K/mTOR inhibition and ionizing radiation (IR) used in two different drug-irradiation schedules (2013, NA)
• Significantly affected canonical pathway “Interferon signaling”, as determined by IPA™ analysis (2013, NA)
• Wnt signaling pathways and the effects in mature synapses (2013, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Oryctolagus cuniculus,Caenorhabditis elegans,Danio rerio,Canis lupus familiaris,Xenopus laevis,Homo sapiens,Lareunionomyces loeiensis)
• Melanogenesis (2013, Homo sapiens,Danio rerio)
• TSC/mTORC1 signaling pathway at the neuronal synapse (2013, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio)
• Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress (2013, Mus musculus,Rattus norvegicus,Bos taurus,Gallus gallus,Danio rerio,Canis lupus familiaris,Homo sapiens,Saccharomyces cerevisiae)
• Gene Expression Profile of the Hippocampus of Rats Subjected to Chronic Immobilization Stress (2013, Mus musculus,Rattus norvegicus,Bos taurus,Gallus gallus,Danio rerio,Canis lupus familiaris,Homo sapiens,Saccharomyces cerevisiae)
• Intracellular tumour necrosis factor receptor-2 (TNFR2) signalling (2013, NA)
• TGF-ß fibrotic pathway (2013, NA)
• Plasma AB mediates systemic insulin resistance in the interaction between Alzheimer disease and diabetes (2013, NA)
• Relation of the insulin pathway to phosphatidylinositols (2013, Homo sapiens,Rattus norvegicus)
• Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia (2013, NA)
• Simplified overview of homologous recombination and non-homologous end-joining (2013, NA)
• Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma (2013, NA)
• Schematic model demonstrating functional involvement of NPM1, RAD50 and XRCC5 in DSB-repair in the progression of ovarian cancer cells (2013, Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Multiple Single-Cell Genomes Provide Insight into Functions of Uncultured Deltaproteobacteria in the Human Oral Cavity (2013, NA)
• cAMP and cGMP pathways (2013, NA)
• Overlay of the insulin-like growth factor-1 (IGF-1) signaling pathway with microarray data for comparison of very small embryonic-like stem cells (VSELs) with hematopoietic stem cells (HSCs) (2013, NA)
• Integrated miRNA-mRNA Analysis Revealing the Potential Roles of miRNAs in Chordomas (2013, Homo sapiens,Mus musculus)
• Cardioprotective mechanisms of T3 (2013, NA)
• MTOR signal pathway in autism spectrum disorders (2013, Homo sapiens,Mus musculus)
• Cytokine and downstream signalling pathways in liver ischaemia reperfusion injury (2013, NA)
• Schematic diagram showing CSFV triggers RIG-I and MDA5 dependent signaling pathway to IRF-3 and NFKB activation to promote the production of antiviral and inflammatory cytokines in porcine alveolar macrophages (2013, Classical swine fever virus,Influenza A virus,Respiratory syncytial virus,Vesicular stomatitis virus,Enterovirus C,Measles morbillivirus,Encephalomyocarditis virus,Dengue virus type 2,Theilers encephalomyelitis virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Homo sapiens,Mus musculus,NA,NA)
• CAND1 as a substrate receptor exchange factor (2013, NA)
• Schematic diagrams showing the mechanisms underlying anti-cancer effects of SSE (2013, NA)
• Network Diagram of the single C (2013, NA)
• Summary of signaling pathways leading to sodium pump regulation in the heart (2013, Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Mustela putorius furo,Mus musculus,Rattus norvegicus,Cavia porcellus,Komagataella pastoris,Ziziphus mauritiana,Digitalis purpurea,Gallus gallus,Xenopus laevis,Homo sapiens,Cerobasis alpha)
• Germline syndromes associated with the Ras signaling pathway.Schematic diagram showing the GM-CSF receptor spanning the phospholipid bilayer (2013, NA)
• Schematic illustration delineating the role of the AKT/Foxo3a/Bim pathway in selenite-induced apoptosis of CRC cells (2013, NA)
• Upregulation of HSP70 and the phosphorylation of STAT1 induced by bortezomib (BTZ) decrease the cytotoxic activity against ovarian cancer cells (2013, NA)
• Ingenuity analysis of representative accumulated proteins in response to inactivation of CRL/SCF system (2013, NA)
• YAP/TAZ are effectors of mechanical stress, GPCR signaling, and the Wnt signaling pathway. Mechanisms of YAP and TAZ regulation by mechanical stress, GPCR signaling, and the Wnt pathway as well as YAP/TAZ as modulators of the Wnt pathway are shown (2013, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,NA)
• Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential (2013, NA)
• Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential (2013, NA)
• Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer (2013, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Notamacropus eugenii,Homo sapiens,Rattus norvegicus,Diaporthe sclerotioides,Meleagris gallopavo)
• Selected summary of the ATM signaling network (2013, NA)
• ATM controls cellular survival in response to DNA damage through multiple pathways (2013, NA)
• Significant signaling pathway networks mined from nitroproteomic dataset (2013, Pinna nobilis,Celithemis elisa,Mytilus galloprovincialis,Homo sapiens,Rattus norvegicus,Bos taurus)
• Interferon signaling pathway (2013, Hepatitis B virus,Influenza A virus,Human alphaherpesvirus 1,Vesicular stomatitis virus,Encephalomyocarditis virus,Non-A non-B hepatitis virus,Hepatitis C virus genotype 1,Aurantiochytrium single-stranded RNA virus 01,Human respirovirus 3,Hepatitis C virus genotype 4,Hepatitis C virus genotype 6,Mus musculus,Rattus norvegicus,Homo sapiens,Cutibacterium acnes,NA)
• Network of the interactions of the miRNAs and their target genes (experimental observed or highly predicted) (2013, Homo sapiens,Mus musculus,Eucalyptus intertexta)
• Putative pathway for neurodegeneration in Alzheimer's disease (2013, Homo sapiens,Mus musculus)
• NF-AT signaling and leukocyte interactions have been enriched by GeneGo (2013, NA)
• STRING analysis of the relationship between genes (2013, NA)
• MTOR signaling pathway in KEGG pathway analysis (2013, Coprinopsis cinerea,Saccharomyces cerevisiae,Arabidopsis thaliana,Aspergillus fumigatus,Agaricus bisporus,Cryptococcus neoformans,Neurospora crassa,Cicer arietinum,Ustilago maydis,Lentinula edodes,Pleurotus ostreatus,Schizophyllum commune,Laccaria bicolor,Amanita muscaria,Cryptococcus neoformans var. neoformans JEC21,Postia placenta,Aspergillus fischeri NRRL 181,Aspergillus clavatus NRRL 1,Pleurotus sp. Florida,Phanerochaete chrysosporium RP-78,Coprinopsis cinerea okayama7130,Tricholoma terreum,Pleurotus sp.,Homo sapiens,NA)
• CAMP signaling pathway and morphogenesis in four selected basidiomycetes (2013, Cryptococcus neoformans,Ustilago maydis,Schizophyllum commune,Coprinopsis cinerea,Saccharomyces cerevisiae,Arabidopsis thaliana,Aspergillus fumigatus,Agaricus bisporus,Neurospora crassa,Cicer arietinum,Lentinula edodes,Pleurotus ostreatus,Laccaria bicolor,Amanita muscaria,Cryptococcus neoformans var. neoformans JEC21,Postia placenta,Aspergillus fischeri NRRL 181,Aspergillus clavatus NRRL 1,Pleurotus sp. Florida,Phanerochaete chrysosporium RP-78,Coprinopsis cinerea okayama7130,Tricholoma terreum,Pleurotus sp.,Homo sapiens,NA)
• Regulated secretory pathway of a model neuroendocrine cell (2013, NA)
• Role of PTPA in the Destruction of Periodontal Connective Tissues (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetus cricetus,Eucalyptus intertexta,Fasciola hepatica,Opisthorchis viverrini,Terfezia albida,Homo sapiens,Treponema denticola)
• Methotrexate mode of action (2013, NA)
• Dectin-1 Regulates IL-10 Production via a MSK1/2 and CREB Dependent Pathway and Promotes the Induction of Regulatory Macrophage Markers (2013, NA)
• NER pathway (2013, Saccharomyces cerevisiae,Homo sapiens)
• Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related Lipolytic Activation in Adipocytes (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Insulin signalling pathway in hepatocytes (2013, NA)
• Inhibition of the mevalonate pathway to override chemoresistance and promote the immunogenic demise of cancer cells (2013, NA)
• Scheme of mechanisms underlying attenuation of cardiac dysfunction induced by endotoxin, after NG-R1 treatment (2013, Mus musculus,Panax notoginseng,Homo sapiens)
• Key mediators of innate and adaptive immunity, development, and signalling (2013, Candida albicans,Candida albicans 23R,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,human metagenome,Elephas maximus)
• (A–D) Possible model of joint formation in developing limbs (2013, NA)
• Ingenuity Pathway Analysis visualization of oncogene interactions (2013, NA)
• Proposed molecular mechanism for the inhibitory effects of zinc on RANKL-induced osteoclastogenesis (2013, NA)
• Roles of Genetic Polymorphisms in the Folate Pathway in Childhood Acute Lymphoblastic Leukemia Evaluated by Bayesian Relevance and Effect Size Analysis (2013, Homo sapiens,Rattus norvegicus,Subgroup B)
• Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers (2013, NA)
• Gene Expression Networks Underlying Ovarian Development in Wild Largemouth Bass (Micropterus salmoides) (2013, Micropterus salmoides,Homo sapiens)
• Macrophages in pancreatic cancer initiation and progression (2013, NA)
• MT1G as a tumor suppressor in thyroid cancer cells through regulating the PI3K/Akt and Rb/E2F pathways.MT1G restoration inhibited phosphorylation of Akt, leading to inhibition of cell growth (2013, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,clinical samples)
• Simplified model of oxidative stress as the central pathogenetic pathway in OSA-associated CV diseases as suggested by animal studies (2013, NA)
• Redox regulation of signaling pathway leading to T-cell activation/proliferation (2013, Homo sapiens)
• Proposed model for AITC-mediated mitochondrial injury and apoptosis (2013, Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Altered colonic metabolites during conventionalisation (2013, Homo sapiens,Mus musculus)
• Neurotrophin signaling pathway is among the pathways downregulated in clinical T1 and upregulated in clinical T2 (2013, Homo sapiens,Sequoia sempervirens)
• The N-linked protein glycosylation pathway (2012, NA)
• Canonical and non canonical NF-kB pathways and related drugs inhibition (2012, Homo sapiens,Mus musculus,Drosophila melanogaster,Curcuma longa,Cervus elaphus)
• Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Canis lupus familiaris,Diaporthe sclerotioides,NA)
• SAC is abundant in kidney intercalated cells (ICs; an A-type acid secreting cell is illustrated here), where it colocalizes extensively with the V-ATPase (2012, NA)
• Repressed (left) and activated (right) canonical HH signaling pathways (2012, NA)
• Mechanisms of activation of HH signaling in hematological cancers (2012, NA)
• The signaling pathways involved in MA-mediated expression levels of IL-6 and IL-8 (2012, NA)
• LKB1及其下游相关靶点信号通路示意结构图Schematic illustration of LKB1 signaling pathway and related downstream targets for cancer therapy (2012, Homo sapiens)
• TDP-43 Identified from a Genome Wide RNAi Screen for SOD1 Regulators (2012, Homo sapiens,Mus musculus,Escherichia coli,Oryctolagus cuniculus,Matthiola incana)
• High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism (2012, Homo sapiens,Mus musculus)
• Receptor Tyrosine Kinases Activate Canonical WNT/Beta-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct Beta-Catenin Phosphorylation (2012, NA)
• Properties of VEGF, FGF, and PDGF receptors and their signaling (2012, Homo sapiens,Mus musculus)
• Emerging signaling pathways in hepatocellular carcinoma (2012, NA)
• EGF decreases sphingolipid biosynthesis transcripts (2012, Homo sapiens)
• EGF decreases free fatty acid (FFA) biosynthesis transcripts (2012, Homo sapiens)
• Putative molecular mechanisms of Wnt signaling, lipid metabolism, and IL-6 effects on insulin signaling in nonobese PCOS adipose tissue (2012, NA)
• Activation of NFKB enhances GRK5 transcription and subsequent expression in myocytes (2012, NA)
• Supernatant transfer assay (2012, NA)
• Disturbed Relaxin Signaling Pathway and Testicular Dysfunction in Mouse Offspring upon Maternal Exposure to Simazine (2012, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Zea mays,Diaporthe sclerotioides,Ovis aries,Equus caballus,PX clade,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens)
• TLR4-induced macrophage activation regulated by NFKB, PI3K/AKT, and MAPK signaling pathways (2012, NA)
• Molecular network of downregulated genes in U373MG cells following exposure to ET-770, the compound 1a (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Cervus elaphus,Drosophila melanogaster,Ecteinascidia thurstoni,Homo sapiens,Mus musculus,Escherichia coli,Schizosaccharomyces pombe)
• Molecular network of upregulated genes in U373MG cells following exposure to ET-770 derivative, the compound 3 (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Cervus elaphus,Drosophila melanogaster,Ecteinascidia thurstoni,Homo sapiens,Mus musculus,Escherichia coli,Schizosaccharomyces pombe)
• The mechanism of chondrocyte integration of cues provided by ECM stiffness and TGFB (2012, NA)
• General scheme illustrating the arachidonic acid pathway through which IL-1B regulates PGE2 production (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• RdgBB binds PA derived from the phospholipase D signaling pathway (2012, NA)
• Genes Involved in the Calvin Cycle and Photorespiration.(A) Schematic of the Calvin cycle and photorespiration pathway in C (2012, Chlamydomonas reinhardtii)
• NGF signaling pathways in mediating neurotrophic and nociceptor effects.Notes: NGF signals through the high-affinity TrkA and low p75NTR receptors (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis)
• Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter (2012, NA)
• RyR2 dysfunction in metabolic syndrome (2012, Mus musculus,Rattus norvegicus,Cavia porcellus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Ryania speciosa)
• Regulation of phenotypic transitions in the fungal pathogen Candida albicans (2012, NA)
• Antimicrobial peptide expression in epidermis (2012, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Aeromonas hydrophila,Priestia megaterium,Pseudomonas sp.,Escherichia coli OP50,Pseudomonas aeruginosa PA14,Staphylococcus aureus 1-B-1,Escherichia coli PA14,Pseudomonas aeruginosa 18A,Methylobacter luteus,Pseudomonas sp. 1B.2,Pseudomonas sp. 2F.1,Drosophila melanogaster,Caenorhabditis elegans,Drechmeria coniospora,Pecoramyces ruminantium,Homo sapiens)
• Autophagy in immunity (2012, NA)
• Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment (2012, NA)
• Reconciling the different roles of Gsk3B in “naïve” and “primed” pluripotent stem cells (2012, Homo sapiens,Mus musculus)
• H2O2-modulated permeability increase and cytoskeleton reorganization via MARCKS phosphorylation in endothelial cells (2012, Bos taurus,Homo sapiens)
• Two mechanisms underlying circadian control of NFKB response (2012, Mus musculus,Homo sapiens)
• Prenatal Exposure to TCDD Triggers Significant Modulation of microRNA Expression Profile in the Thymus That Affects Consequent Gene Expression (2012, NA)
• Molecular interaction between estrogen and thyroid hormone (2012, Homo sapiens)
• Activation of the mitogen-activated protein kinase (MAPK) pathway in thyroid cancer by mutant BRAF (2012, NA)
• NFKB signaling pathway in ATL (2012, Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Human T-cell lymphotropic virus,Human T-lymphotropic virus 2,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos gaurus)
• Two pathways, Ga13 pathway and Gai pathway, are connected via Gaq pathway (2012, NA)
• Simplified overview of the canonical Wnt signaling pathway (2012, Homo sapiens)
• C-srcregulating primordial follicle activation and growth through PI3K → PKC → MAPK signaling pathway (2012, Mus musculus,Rattus norvegicus,Cricetus cricetus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Dipturus trachyderma)
• Therapeutic Effects of Astragaloside IV on Myocardial Injuries: Multi-Target Identification and Network Analysis (2012, NA)
• Transcriptional regulation of PDPN expression (2012, NA)
• ATF-2 is a nuclear target of p38/Jun N-terminal protein kinase (JNK) (2012, NA)
• mTORC1 regulation (2012, NA)
• The dual functions of APE1/Ref-1 (2012, Saccharomyces cerevisiae,Glycine max,Curcuma longa,Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli 53A,Homo sapiens,Bos taurus)
• Apoptotic and necrotic targets modulate viability of epithelial responder cells by eliciting multiple recognition-dependent signaling pathways (2012, NA)
• Diverse cohesinopathy phenotypes (2012, NA)
• Agonistic and Antagonistic Roles for TNIK and MINK in Non-Canonical and Canonical Wnt Signalling (2012, NA)
• Immune response pathway map enriched with genes down-regulated in the tumorgraft forming patient tumors (2012, Phleum pratense,Nelumbo nucifera,Homo sapiens,Mus musculus,Bos taurus)
• Transcriptional Differences between Rhesus Embryonic Stem Cells Generated from In Vitro and In Vivo Derived Embryos (2012, Bos taurus,Oryctolagus cuniculus,Ovis aries,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Arabidopsis thaliana,Human immunodeficiency virus 1,Macaca mulatta,Cricetulus griseus,Human betaherpesvirus 5,Drosophila melanogaster)
• Scheme to explain the increased production of HA in fro/fro (NSMase2−/−) mouse fibroblasts (2012, NA)
• Gene Expression and Functional Annotation of the Human Ciliary Body Epithelia (2012, Bos taurus,Oryctolagus cuniculus,Ovis aries,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Erythroxylum coca,Homo sapiens,Gallus gallus)
• WNT signalling pathway map enriched with genes up-regulated in tumorgraft-forming tumors (2012, Phleum pratense,Nelumbo nucifera,Homo sapiens,Mus musculus,Bos taurus)
• Alterations in the FGFR signalling pathway that influence breast cancer (2012, Homo sapiens,Mus musculus,Xenopus laevis,Mouse mammary tumor virus)
• Impaired immune system in patients with systemic lupus erythematosus (SLE) (2012, Homo sapiens,Mus musculus,Avian erythroblastosis virus E26)
• A20 in the nuclear factor-kappa-B (NFKB) pathway (2012, Homo sapiens,Mus musculus,Avian erythroblastosis virus E26)
• Viral proteins inhibit nucleic acid receptors of the intracytosolic innate immune response (2012, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Human gammaherpesvirus 8,Vaccinia virus,Variola virus,Myxoma virus,Cowpox virus,Zaire ebolavirus,Borna disease virus,Equid alphaherpesvirus 4,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Bacteriophage sp.,NA,NA)
• tBID structure and mechanism of action (2012, NA)
• Cytosolic fumarate biosynthetic pathway in S (2012, Saccharomyces cerevisiae,Homo sapiens)
• RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans (2012, Caenorhabditis elegans,Homo sapiens)
• Nuclear receptors LXRs, FXR, and PXR as central regulators of renal lipid, inflammation and oxidative stress (2012, NA)
• Proposed model of the induction of endothelial proinflammatory response and barrier dysfunction by P (2012, NA)
• The role of dimeric TIR platform for the inhibition and activation of MyD88 signaling pathway (2012, NA)
• Cdx gene regulation in normal and malignant hematopoiesis (2012, Homo sapiens)
• Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis (2012, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis str. Erdman ATCC 35801,Homo sapiens,Mus musculus,Human immunodeficiency virus,Sequoia sempervirens)
• GlyRA2 and GlyRA3 mediate inhibition using different inhibitory circuits (2012, Oryctolagus cuniculus,Capra hircus,Felis catus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Necturus maculosus)
• Anti-apoptotic effects of HIF-1Alpha-modified MSCs (2012, NA)
• p53-dependent and -independent therapeutic strategies for cancer cells (2012, NA)
• LPA-induced platelet signalling during platelet shape change (2012, NA)
• Schematic illustration demonstrating putative signaling pathways involved in PDGF-BB-mediated increase in proliferation of NPCs (2012, Human immunodeficiency virus 1,Human immunodeficiency virus,adeno-associated virus 2,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana)
• Altered pancreatic beta cell mechanism silencing alpha and delta cells (2012, NA)
• Impaired lipid metabolism induced by HFD or genetic manipulation induces heart dysfunction (2012, NA)
• JAK/STAT signaling pathway is targeted by RVFV NSs protein at different levels (2012, NA)
• Formation of the NFKB-stimulating TNFR1 signaling complex (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,Cryptosporidium parvum,NA)
• Systematic Analysis of microRNA Targeting Impacted by Small Insertions and Deletions in Human Genome (2012, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas (2012, Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• CaMK4/CREB/IRS-2 Cascade Stimulates Proliferation and Inhibits Apoptosis of Beta-Cells (2012, NA)
• Class I phosphoinositide-3-kinase (PI3K) signaling pathway (2012, NA)
• Two proposed models of ephrin-B reverse signaling in palatal EMT based on current evidence (2012, NA)
• Schematic overview of the results from the present study indicating WNT-5A secretion from astrocytes and the WNT-5A-induced signaling pathway towards ERK1/2 regulating distinct aspects of the proinflammatory transformation of microglia (2012, NA)
• PTEN/Akt Signaling Controls Mitochondrial Respiratory Capacity through 4E-BP1 (2012, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• TGFB pathway and regulations by ubiquitination and PPARG (2012, NA)
• PPARG in the pathogenesis of fibrosis (2012, NA)
• Boolean network model of the HGF-induced keratinocyte migration (2012, Arabidopsis thaliana,Armoracia rusticana,Homo sapiens,Rattus norvegicus)
• Analysis of pathway crosstalk based on protein-protein interaction networks (2012, Homo sapiens,Arabidopsis thaliana,Helicobacter pylori)
• RAS pathway and its correlation with RASopathies (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• RAS Network: cross-links in hypertrophy (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Lipopolysaccharide/TLR4 signalling lipopolysaccharide recognition.Notes: Overview of LPS/TLR4 signalling LPS recognition is facilitated by lipopolysaccharide-binding protein and CD14, and is mediated by TLR4/MD-2 receptor complex (2012, Respiratory syncytial virus,Enterovirus C,Enterovirus,Human rhinovirus sp.,rhinovirus A2,Homo sapiens,Osphranter robustus)
• Pathological functions of LOX family oxidases during cancer progression and metastasis (2012, Homo sapiens)
• Genome-Wide Profiling Identified a Set of miRNAs that Are Differentially Expressed in Glioblastoma Stem Cells and Normal Neural Stem Cells (2012, Bos taurus,Canis lupus familiaris,Homo sapiens,Mus musculus)
• Signal transducer and activator of transcription 3 (Stat3) signaling (2012, Homo sapiens)
• Possible signaling pathways by which CHK1 inhibitors activate ERK, and mechanisms by which MEK1/2 and SRC inhibitors potentiate CHK1 inhibitor lethality (2012, Homo sapiens)
• Usually growth factors bind and activate EGFR on the cell membrane of cancer cells to stimulate the down-stream PI3K-Akt-mTOR and Ras-Raf-MEK pathway (2012, NA)
• Central role of AP convertase in complement activation (2012, Neisseria meningitidis,Sugarcane Ramu stunt disease phytoplasma,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Activation of p38 MAPK downstrem of TNFR1 (2012, NA)
• Mitogen activated protein [MAP] kinase signalling pathways (2012, NA)
• Transcriptional Targets of Mutant FOXL2 in Granulosa Cell Tumours (2012, NA)
• Lovastatin Induces Multiple Stress Pathways (2012, NA)
• EnrichNet: network-based gene set enrichment analysis (2012, Homo sapiens)
• Overall picture of the physiology of FGF-23 and its role in phosphate homeostasis (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Arachis hypogaea)
• Ensemble representation of EGF signalling network (2012, NA)
• Major pathways involved in motor neuron death (2012, NA)
• mTOR signaling (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa,Streptomyces hygroscopicus,Cerobasis alpha)
• B-RAF kinase inhibition by Zelboraf, and molecular mechanisms underlying resistance to Zelboraf treatment (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Drought stress effects on maize ovary tissue at 1 (2012, NA)
• LPS/TLR-4 signaling pathway.Notes: LPS is delivered to CD14 by LBP, which in turn transfers LPS to TLR-4 (2012, NA)
• Signaling cascades mediated by plexin-A and plexin-B, and their crosstalk with oncogenic pathways in gliomas (2012, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Transforming growth factorB (TGFB)-activated kinase 1 (TAK1) activation by TGFB in mesangial cells (2012, NA)
• Outline of transforming growth factorB (TGFB) signaling (2012, NA)
• TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• New molecular insights into peripheral T cell lymphomas (2012, NA)
• Illustration of the PI3K pathway signaling pathway (2012, NA)
• TLR2 signaling (2012, NA)
• Molecular pathogenesis of mantle cell lymphoma (2012, Homo sapiens)
• Looking in the miR-ror: TGFB–mediated activation of NFKB in glioma (2012, NA)
• Ang-II signaling to the endothelial cytoskeleton via MARCKS and H2O2 (2012, Mus musculus,Bos taurus,Homo sapiens)
• Main metabolic reactions in central carbon metabolism.A) Xylose can be assimilated through two pathways: the fungal oxidoreductive pathway consisting of XR and XDH or the bacterial isomerization pathway via an XI (2012, Saccharomyces cerevisiae,Homo sapiens)
• Model illustrates proposed two pathways of regulation of S100A4 mediated by HBXIP (2012, NA)
• Autophagy within antigen donor cells and cross-priming (2012, Influenza A virus,Human papillomavirus,Homo sapiens,Mus musculus,Gallus gallus)
• Major therapeutic targets for inhibition of donor-reactive memory T cell responses (2012, NA)
• Schematic diagram showing a putative GSH system and its role in LAB (2012, NA)
• Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells (2012, NA)
• CD44 potentiates T cell activation, expansion, contraction, and maintenance of memory cells (2012, Escherichia coli,Mycobacterium tuberculosis,unidentified influenza virus,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Mus musculus,Gallus gallus,Ovis aries)
• Possible signaling pathway activated by the phytol-based immunostimulant PHIS-01 (2012, NA)
• MyD-88 dependent TLR signaling pathway (2012, NA)
• Mutations identified in patients with diabetes as well as hyperinsulinemia and hyperproinsulinemia (2012, NA)
• Schematic diagram depicting the potential interactions between EGF, S100A11, and Ca2+signaling pathway in human endometrial cell (2012, Homo sapiens,Mus musculus)
• Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells (2012, NA)
• Signaling pathways important for C (2012, NA)
• Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway (2012, Armoracia rusticana,Diaporthe sclerotioides,Musa acuminata,Prunus dulcis,Mus musculus,Rattus norvegicus,Rattus rattus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• The inductive and effector sites for the mucosal B-cell response in CD (2012, unidentified influenza virus,Adeno-associated virus,Enterovirus C,Triticum aestivum,Hordeum vulgare,Homo sapiens,Mus musculus,Ovis aries,gut metagenome)
• Interaction between Ryk and Wnt signaling pathways (2012, NA)
• Putative mechanisms of the effect of the Kv1 (2012, Rattus norvegicus,Homo sapiens)
• Insights into Pancreatic Cancer Etiology from Pathway Analysis of Genome-Wide Association Study Data (2012, Homo sapiens,Boykinia major)
• Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells (2012, NA)
• Linking cellular metabolism with the circadian clock transcriptional complex (2012, NA)
• Autophagy induction by TLR stimulation (2012, NA)
• visualization of the proposed cardioprotective mechanism of action of metformin in the human heart after myocardial infarction, resulting in improved systolic and diastolic function (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Role of autophagy during innate immunity (2012, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Mycobacterium tuberculosis variant africanum,Mycobacterium tuberculosis TRS1,Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human alphaherpesvirus 2,Sindbis virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Serranus cabrilla,NA,NA)
• Heterotypic adhesion-induced mast cell activation (2012, NA)
• Pre-treatment expression of TLR, RIG-I and IFN-beta pathway genes compared between the two patient groups (2012, Homo sapiens)
• Signaling involved in MUC4 expression upon Nicotine, IFNG and Retinoic acid stimulation (2012, Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus,Bos taurus)
• Diagram of bioenergetics pathways in sperm (2012, NA)
• Cellular mechanisms of neurotransmission in the mesolimbic dopamine (DA) reward pathway (2012, NA)
• Changes in hepatic gene expression in the KEGG PPAR signalling pathway in SNEB compared to MNEB cows (2012, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• Wortmannin Reduces Insulin Signaling and Death in Seizure-Prone Pcmt1−/− Mice (2012, NA)
• In Vivo Tumorigenesis Was Observed after Injection of In Vitro Expanded Neural Crest Stem Cells Isolated from Adult Bone Marrow (2012, Mus musculus,Homo sapiens)
• Temperature Dependent Proteomic Analysis of Thermotoga maritima (2012, NA)
• Spectrum of somatic mitochondrial mutations in five cancers (2012, Homo sapiens)
• Schematic diagram showing the proposed crosstalk between integrins and GPCRs in ASM cell contraction signaling (2012, NA)
• Hepatocyte growth factor (HGF)–cMET axis signaling network and ongoing targeted therapy strategies (2012, NA)
• Interactions of Rex with host pathways, uncovered and covered (2012, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Human T-cell leukemia virus type I,Human T-cell lymphotropic virus,Human T-lymphotropic virus 2,Simian T-lymphotropic virus 3,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Schematic diagrams of the cytoprotective effects of H2S against hypoxia/ischemia-induced injury (2012, NA)
• PPAR signaling pathway is significantly altered by 1A,25(OH)2D3 treatment on dpf 6 [120-h 1A,25(OH)2D3 treatment] (2012, NA)
• The integrated large-scale logical model (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Macaca fascicularis,Bos taurus,Helicobacter pylori)
• Biological insights obtained by combining logical modeling and experimental data (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Macaca fascicularis,Bos taurus,Helicobacter pylori)
• The canonical translation pathway in eukaryotes with the ribosomal recycling and initiation phases shown in detail (2012, NA)
• GSK3 regulates a variety of pathways involved in neurodevelopment (2012, NA)
• S6K1 in ER-positive breast cancer (2012, NA)
• Translational impact of the mTOR signaling pathway (2012, NA)
• Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Taraxacum officinale,Homo sapiens)
• NO-cGMP pathway (2012, Mus musculus,Homo sapiens)
• Ubiquitin ligase complexes SCF and APC/C in ubiquitin-mediated proteolysis of regulatory molecules essential for cell cycle control (2012, NA)
• Model depicting the molecular underpinnings of lamin B2 origin licensing (2012, NA)
• Regulation of the CCL2 Gene in Pancreatic Beta-Cells by IL-1B and Glucocorticoids: Role of MKP-1 (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Encephalomyocarditis virus)
• Acute phase canonical pathway and corresponding acute phase reactants identified as significant for interaction effect (2012, Homo sapiens,Mus musculus)
• Putative scheme of the cellular metabolism in the hydrogen producing arachaeon T (2012, NA)
• Skewed Th17/Treg cell differentiation in patients with BD, a hypothesis (2012, Escherichia coli,Mycobacterium tuberculosis,Streptococcus pyogenes,Mycobacterium leprae,Streptococcus sanguinis,Homo sapiens,Cricetulus griseus)
• Immune response to phagosome in antigen presentation network pathway map associated with the proteins identified as differentially regulated during zebrafish caudal fin regeneration (2012, Danio rerio,Homo sapiens)
• The canonical Wnt signaling pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22 (2012, NA)
• Crosstalk among Wnt, insulin, and FOXO signaling cascades (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease (2012, Homo sapiens,Mus musculus)
• Genome-Wide Characterization of Pancreatic Adenocarcinoma Patients Using Next Generation Sequencing (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Bikinia letestui,S2-like reptarenavirus)
• Molecular markers expressed in activated mTOR signaling pathway (2012, NA)
• Putative mechanisms responsible for UPR activation by CD147 in human HCC cells (2012, NA)
• Cholesterol is converted to pregnenolone by cytochrome P450scc inside steroidogenic mitochondria (2012, NA)
• Proposed signaling pathways of H2S during angiogenesis (2012, NA)
• Regulation of the human TRAIL gene (2012, NA)
• SP-A-regulated signaling pathways in human macrophages (2012, Homo sapiens,Bos taurus,Allogromia sp. A)
• Salmonella central carbon metabolism (2012, NA)
• Neutral lipid and phospholipid biosynthetic pathways (2012, NA)
• Serum and Antibodies of Glaucoma Patients Lead to Changes in the Proteome, Especially Cell Regulatory Proteins, in Retinal Cells (2012, NA)
• Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease (2012, NA)
• Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease (2012, NA)
• Tension and Robustness in Multitasking Cellular Networks (2012, NA)
• Mammalian unfolded protein response (UPR) pathways (2012, NA)
• Mitophagy inhibits pathways of mitochondrial dysfunction and associated cell death and inflammation (2012, NA)
• Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells (2012, NA)
• Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes (2012, NA)
• Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes (2012, NA)
• Molecular Phenotyping of Immune Cells from Young NOD Mice Reveals Abnormal Metabolic Pathways in the Early Induction Phase of Autoimmune Diabetes (2012, NA)
• Proposed signaling mechanisms regulating mean arterial pressure (MAP) and baroreflex function (BRS) within the brain dorsal medulla of transgenic rats with long-term alterations in brain renin-angiotensin system (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Activated CD47 is a proximate regulator of multiple cell survival and cell death pathways (2012, NA)
• Proposed model describing the signaling cascades leading to HAECs cytoskeleton remodeling following either thrombin stimulation or HLA class I ligation (2012, Homo sapiens)
• Three major signaling pathways are altered in prostate cancers (2012, NA)
• Heme metabolism (2012, NA)
• Single gene and protein network generated by Approach 3 (Network 1) that demonstrated significance as a clinical relapse predictor following a stringent permutation based test (2012, NA)
• The effects of curcumin on the TNFA receptor and its downstream signaling pathway (2012, NA)
• Summary of the biochemical pathways for parathyroid hormone (PTH)-, dopamine-, and FGF-23-mediated inhibition of phosphate transport in the renal proximal convoluted tubule (2012, NA)
• MYCN-dependent apoptosis and the MDM2–p53 pathway (2012, Homo sapiens,Mus musculus)
• Simplified schema of putative signaling pathways accountable for the differential responses of A549 (A) and SNB19 (B) cell lines to Hsp90 inhibition and IR (2012, NA)
• High Throughput Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery (2012, Human gammaherpesvirus 4,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,West Nile virus,Encephalomyocarditis virus,Human rhinovirus sp.,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Bellapiscis medius,Saururus chinensis)
• MAPK/ERK signaling and the hallmarks of cancers (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic diagram showing the proposed mechanism by which intracellular signaling pathway involved in resveratrol-induced brain endothelial cell angiogenesis (2012, NA)
• Schematic diagram shows the role of miR-132/212 in Ang II-induced VSMC dysfunction (2012, NA)
• Suppressed RNA-Polymerase 1 Pathway Is Associated with Benign Multiple Sclerosis (2012, NA)
• The molecular mechanism of bilirubin-induced growth arrest in hVSMC (2012, NA)
• Overall scheme of hypothetical effect of endocannabinoid signaling in human melanocytes (2012, NA)
• PKCE regulation in neuroprotection against ASPD (2012, NA)
• Two NFKB activation pathways induced by RANK, CD40, and LtB R signaling (2012, NA)
• Simplified flavonoid biosynthetic pathway showing steps specific to the biosynthesis of flavonols (VvFLS), proanthocyanidins (VvLAR and VvANR), and anthocyanins (VvGST); genes included in expression analysis are in bold type (2012, Arabidopsis thaliana,Malus domestica,Vitis vinifera,Fragaria x ananassa,Diospyros kaki,Vitis labrusca x Vitis vinifera)
• Hh pathway activation, inhibition, and mechanisms of drug resistance (2012, Homo sapiens,Mus musculus,Drosophila melanogaster)
• One of the KEGG prostate cancer pathways (b) the paths detected by our method (2012, Homo sapiens,Saccharomyces cerevisiae,Escherichia phage T7,Simian retrovirus 2)
• (A, B) Schematic view of the Fas/Fas-ligand (FasL) apoptotic signaling pathway (2012, Homo sapiens,Mus musculus,Bos taurus)
• Basophils deliver activation signals to mucosal and lymph node B cells (2012, NA)
• Four major molecular pathways activated by tyrosine kinase receptor B (TrkB) and IGF-1 receptor (IGF-1R) (2012, NA)
• Rac and RhoA signaling pathways during cytokinesis (2012, NA)
• Activation of the IKK-NFKB pathway by radiotherapy and chemotherapy (2012, NA)
• Cross-Species Genome Wide Expression Analysis during Pluripotent Cell Determination in Mouse and Rat Preimplantation Embryos (2012, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,NA)
• Modulation of type I IFN production by PRRSV (2012, Influenza A virus,Porcine reproductive and respiratory syndrome virus,Transmissible gastroenteritis virus,Poliovirus 3,Equine arteritis virus,Lactate dehydrogenase-elevating virus,Thogotovirus thogotoense,Simian hemorrhagic fever virus,Lelystad virus,Diaporthe sclerotioides,Pyrus communis,Cinchona pubescens,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,NA,NA)
• Proposed model of SubAB-induced PERK-mediated apoptosis signaling pathway in HeLa cells (2012, NA)
• Platelet-Derived Growth Factor CC-Mediated Neuroprotection against HIV Tat Involves TRPC-Mediated Inactivation of GSK 3beta (2012, Human immunodeficiency virus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Gallus gallus,Capra hircus,Xenopus laevis,Macaca nemestrina,Simian-Human immunodeficiency virus)
• Canonical and non-canonical NFKB pathways (2012, Mus musculus,Rattus norvegicus,Human papillomavirus,Human T-cell leukemia virus type I,Homo sapiens,Curcuma longa)
• TGFB and FGF signaling pathways in tongue development (2012, NA)
• TGFB in bone metastasis: novel therapeutic perspectives (2012, NA)
• Signaling pathway for the cytoprotective effect of STI571 in TRAIL-treated colon cancer cells (2012, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Non-Antioxidant Properties of Alpha-Tocopherol Reduce the Anticancer Activity of Several Protein Kinase Inhibitors In Vitro (2012, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Candida dubliniensis,Homo sapiens,Gallus gallus)
• Coordinate regulation by NR signaling pathways of genes encoding enzymes in the de novo purine base biosynthesis pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Effects of sleep deprivation on the insulin signaling pathway (2012, Mus musculus,Homo sapiens)
• Insulin-like growth factor (IGF)-1 signal transduction (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling mechanisms leading to endothelial dysfunction under diabetes (2012, NA)
• GABA Maintains the Proliferation of Progenitors in the Developing Chick Ciliary Marginal Zone and Non-Pigmented Ciliary Epithelium (2012, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Rattus norvegicus,Bos taurus)
• Signaling pathways and molecular mechanisms mediating dendritic spine injury and drebrin A loss in epilepsy (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Agaricus bisporus)
• Identification of transcripts and proteins associated with hemocytes (2012, Drosophila melanogaster,Plasmodium falciparum,Crassostrea gigas,Schistosoma japonicum,Branchiostoma floridae,Euprymna scolopes,Azumapecten farreri,Saccoglossus kowalevskii,Crassostrea virginica,Hirudo medicinalis,Pinctada fucata,Branchiostoma belcheri,Argopecten irradians,Glossina morsitans morsitans,Acanthaster planci,Haliotis diversicolor,Haliotis discus,Sepia esculenta,Brachionus manjavacas,Mus musculus,Cavia porcellus,Homo sapiens,Lareunionomyces loeiensis,Xenopus tropicalis,Aliivibrio fischeri)
• Overlap in FcERI, FcGRIII, and FcGRIIB signaling (2012, NA)
• Oncogene-induced senescence in pilocytic astrocytoma (2012, NA)
• Canonical Wnt pathway (2012, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Paraechinus aethiopicus)
• Intracellular signaling pathway of endocannabinoid system in neuroprotection (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Bioinformatic analysis of the differentially expressed proteins.The list of the MS-identified protein spots from 2D-DIGE was subjected to String (v (2012, NA)
• The Bad, the Good, and the Ugly about Oxidative Stress (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Ginkgo biloba)
• The signaling pathways occurring during neural induction in the amphibian ectoderm cells (left panel) and in the ESCs (right panel) (2012, NA)
• TRPC1 channel is a major regulator of EGFR signaling (2012, NA)
• Working model for onset of emphysema in Fut8+/− mice upon exposure to CS (2012, Mus musculus,Homo sapiens)
• Control of Pax3 expression in the caudal neurectoderm via NCE2 (2012, Mus musculus,Homo sapiens)
• Sketch of the relationship between IGF signalling, the PI3K pathway and androgen responses in the prostate (2012, NA)
• Activity of the ERK1/2 MAPK cascade can be modulated by inputs at different sites in the pathway (2012, NA)
• Calcineurin reverses negative feedback on B-Raf to permit ERK1/2 activation by nutrients in pancreatic B cells (2012, NA)
• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance (2012, NA)
• Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer (2012, NA)
• Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma (2012, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human papillomavirus type 16)
• Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway (2012, NA)
• Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway (2012, NA)
• Pathways identified by IPA (2012, Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Mus musculus,Bos taurus,Larimichthys crocea)
• Transcriptional regulation network centered on SP1 involves many genes of interest from pathways enriched in memory impairment (2012, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified)
• Proposed model of WNK4 signaling pathway mediating NCC regulation in DCT (2012, Mus musculus,Homo sapiens)
• Signaling pathways mediating Beta-adrenergic effects on the cardiac microtubule network (2012, Felis catus,Homo sapiens)
• ATP release from erythrocytes in response to activation of the prostacyclin receptor (2012, NA)
• Autophagy and polyglutamine diseases (2012, NA)
• Inducing autophagy by inhibiting the mTOR pathway.mTOR is a downstream effector of the class I phosphoinositol 3-kinase (PI3K) pathway (2012, NA)
• Adrenergic Alpha-1 Pathway Is Associated with Hypertension among Nigerians in a Pathway-focused Analysis (2012, Homo sapiens,Rattus norvegicus)
• PD-1 signaling in effector T cells (2012, Homo sapiens,Mus musculus)
• Ingenuity pathway analysis (IPA) identified critical expression networks containing genes that are significantly correlated with the extent of necrosis in The Cancer Genome Atlas (TCGA) glioblastoma (GBM) samples from all subclasses (A and B) (2012, NA)
• EGFR signaling pathway (reprinted with permission from BioCarta Pathways (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Photosynthetic electron sinks in higher plants (2012, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Glycine max,Embryophyta,Hordeum vulgare,Cucumis sativus,Spinacia oleracea,Pisum sativum,Rumex patientia,Erebia epipsodea)
• Suggested mechanisms by which NPs may induce molecular signaling cascades leading to upregulation of the HMG-CoA reductase pathway in the liver of exposed C57BL/6 mice (2012, NA)
• Two distinct DC semi-maturation pathways induce different types of regulatory T cells (2012, Trypanosoma brucei,Leishmania major,Leishmania amazonensis,Patella vulgata,Nippostrongylus brasiliensis,Echinococcus multilocularis,Streptococcus pyogenes,Lacticaseibacillus rhamnosus,Phocaeicola vulgatus,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Arachis hypogaea,Morchella esculenta,Homo sapiens)
• Nuclear receptors and photoreceptor differentiation in mice (2012, Homo sapiens)
• Genetic events involved in thyroid tumor initiation and progression (2012, NA)
• Wnt signaling pathways (2012, NA)
• Gene regulatory networks in mammalian sex determination (2012, Bos taurus,Capra hircus,Ovis aries,Paraechinus aethiopicus,Eutheria,Mus musculus,Rattus norvegicus,Mus musculus domesticus,Mus poschiavinus,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• Anaplastic lymphoma kinase signaling (2012, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Equus caballus,unidentified,Corynebacterium phage gamma)
• LRP5, LRP6 and LRP4 are important components of the Wnt/Beta-catenin signaling pathway (2012, Mus musculus,Homo sapiens)
• K63-linked polyubiquitination in the activation of canonical and non-canonical NFKB signaling pathway (2012, Cervus elaphus,Equus asinus x Equus caballus,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Alocasia macrorrhizos)
• The cross-talk between extracellular and intracellular progesterone signaling pathways in female reproductive behavior (2012, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Mesocricetus auratus,Gallus gallus,Xenopus laevis,Salmo trutta trutta,Symphonia globulifera,Sorbus aucuparia,Homo sapiens)
• Regulation of FOXO3 and Beta-catenin by AKT, ERK, and IKK signaling pathway (2012, NA)
• Regulation of Mcl-1 and Snail by AKT, ERK, and IKK signaling pathway (2012, NA)
• Most significant canonical pathway from this study (2012, Nicotiana tabacum,Bikinia letestui,Homo sapiens,Mus musculus,Pekania pennanti)
• Factors and molecular mechanisms that influence ecdysone synthesis and the timing of critical weight attainment (2012, NA)
• Personalized Pathway Enrichment Map of Putative Cancer Genes from Next Generation Sequencing Data (2012, NA)
• High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes (2012, NA)
• High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes (2012, NA)
• High-Throughput Sequence Analysis of Turbot (Scophthalmus maximus) Transcriptome Using 454-Pyrosequencing for the Discovery of Antiviral Immune Genes (2012, NA)
• Influence of Tc-axin and Tc-pangolin on canonical Wnt signaling and role of Wnt signaling in axis formation in the bilateria (2012, Drosophila melanogaster,Tribolium castaneum,Homo sapiens)
• Canonical WNT signaling pathway (2012, NA)
• Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor Development (2012, NA)
• Gene mutations involved in PTC carcinogenesis (2012, NA)
• Translation initiation control during growth factor stimulation, cellular stress, and cellular physiology (2012, NA)
• Translation initiation control relays signals to erythroid and granulocytic differentiation (2012, NA)
• TWEAK signaling pathway: illustration of the TWEAK signaling pathway as visualized in NetSlim web page (2012, Homo sapiens,Mus musculus)
• Overview of TLR signaling (2012, NA)
• TLR4 signaling in alcoholic steatohepatitis and fibrosis (2012, NA)
• P2X7 receptor-induced signaling pathway involved in MV shedding (2012, NA)
• Activation and inactivation pathways for hypoxia-induced factor 1 (HIF-1) in normoxia, hypoxia/anoxia, and cancer (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Citrus macrophylla)
• Gene expression by PPARs and inflammatory transcription factors: transactivation and transrepression mechanisms (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Citrus macrophylla)
• COX and 5-LO pathway in the metabolism of PGE2 and pLT for in vitro diagnosis of NSAID-triggered hypersensitivity (2012, Homo sapiens)
• Targeting the urokinase plasminogen activator receptor (uPAR) pathway leads to attenuation of wound repair via different mechanisms (2012, NA)
• H. pylori-induced miR-155 expression in macrophage immune cells (2012, Mus musculus,Helicobacter pylori,Homo sapiens)
• mTORC1 signaling and regulation of pancreatic Beta-cell mass (2012, Mus musculus,Homo sapiens)
• AMPK in DHT's inhibitory effect in FSH-mediated mitogenesis (2012, NA)
• Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors (2012, NA)
• Central IR/IGF-1 signaling (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Lareunionomyces loeiensis,prion)
• Regulation of homeostatic AMPAR trafficking and turnover (2012, NA)
• Several growth factor signals activate cell membrane receptor tyrosine kinases leading to activation of downstream interacting signal transduction pathways (PI3K/AKT, RAF/MAPK, and MTOR) (2012, NA)
• The role of neuronal chemokine (FKN) and neuronal cytokine (IL-34) in microglial phagocytosis and neuroprotection (2012, Mus musculus,Rattus norvegicus,Escherichia coli,Streptococcus pneumoniae,Homo sapiens,Candida dubliniensis)
• Linking pathways to disease: Crohn's disease (from Wang et al (2012, Mus musculus,Rattus norvegicus,Staphylococcus aureus,Haemophilus influenzae,Homo sapiens,Bursera graveolens,NA)
• P2X4R-p38 MAPK is a core signaling pathway through which spinal microglia and peripheral macrophages contribute to neuropathic pain and inflammatory pain (2012, NA)
• Examples of signal transduction pathways in astroglial cells following P2X7R activation (2012, NA)
• Examples of signal transduction pathways in astroglial cells following P2Y1R activation (2012, NA)
• Antigen-mediated chemotaxis (2012, NA)
• Synthesis of eicosanoids and their actions in mast cells (2012, NA)
• Integrative Gene Regulatory Network Analysis Reveals Light-Induced Regional Gene Expression Phase Shift Programs in the Mouse Suprachiasmatic Nucleus (2012, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Drosophila melanogaster)
• Metabolic Profiling of the Protozoan Parasite Entamoeba invadens Revealed Activation of Unpredicted Pathway during Encystation (2012, Entamoeba invadens,Homo sapiens)
• IQGAP1 regulates cell homeostasis through mTORC1 (2012, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens,Mus musculus)
• Stress-activated MAPK signaling pathway (2012, NA)
• Signaling pathways of TNFAlpha-induced hepatocyte death (2012, NA)
• UCB interaction with neural plasma membrane (A) and pathways by which UCB may affect neuronal function (B) (2012, NA)
• Diagram of signaling pathways in a principal cell that have been exploited to bypass the VP/VP type 2 receptor (V2R) pathway, and induce apical membrane accumulation of AQP2 (2012, NA)
• RIP-1 in programmed necrosis (2012, NA)
• Mitochondrial quality control by the p38 stress kinase (2012, NA)
• The WNT10b and galanin-mediated signaling pathways linked to adipogenesis (2012, Zea mays,Vachellia nilotica,Homo sapiens,Mus musculus,Mouse mammary tumor virus,Triportheus paranensis)
• Signaling pathways involved in IL-4-induced DC-SIGN expression on THP-1 cells (2012, NA)
• The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection (2012, NA)
• EpCAM and its potential role in tumor-initiating cells (2012, NA)
• EpCAM and its potential role in tumor-initiating cells (2012, NA)
• Signaling roles for import proteins (2012, NA)
• N-BPs may modulate myeloma progression through their effects on the mevalonate pathway and directly on MM plasma cells, bone marrow cells and immune cells in the bone marrow (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Cladophora subtilissima)
• Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells (2012, Homo sapiens,Boswellia serrata)
• Promise of dual targeting Akt/mTOR signaling in lethal prostate cancer (2012, Homo sapiens,Mus musculus)
• cAMP signalling pathway in S (2012, NA)
• Genes with mutations that cause monogenic, severe T-cell immunodeficiency in humans can be intrinsic to the thymic epithelium or to T cells (2012, Mus musculus,Cricetulus griseus,Homo sapiens,Human immunodeficiency virus 1,Diaporthe sclerotioides,Staphylococcus aureus)
• Activation of TAZ upon epithelial-to-mesenchymal transition in human breast cancer cells (2012, NA)
• Transrepression of estrogen receptor and NFKB (2012, NA)
• Estrogen receptor functional domains and signal transduction schemes (2012, NA)
• Protein processing in endoplasmic reticulum is altered in Manf mutants (2012, Saccharomyces cerevisiae,Malus domestica,Matthiola incana,Saccharomyces cerevisiae SK1,Drosophila melanogaster,Caenorhabditis elegans,Rhagoletis zephyria,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Moloney murine leukemia virus)
• Changes in gene expression related to endocytosis in Manf mutants (2012, Saccharomyces cerevisiae,Malus domestica,Matthiola incana,Saccharomyces cerevisiae SK1,Drosophila melanogaster,Caenorhabditis elegans,Rhagoletis zephyria,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Moloney murine leukemia virus)
• Pathways activating and inhibiting complement (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Lareunionomyces loeiensis)
• Epistasis network for WTCCC GWAS of bipolar disorder (2012, NA)
• Concept of molecular network in schizophrenia (2012, Homo sapiens,Meleagris gallopavo)
• Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes (2012, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Subcellular localization of components of the PIWI-piRNA pathway and the proposed mechanism of TE suppression by this pathway (2012, NA)
• Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes (2012, NA)
• Pro- and anti-inflammatory effects of heat and heat shock proteins (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• AB1–42-activated cellular signaling pathways and AMY3 role in AD (2012, NA)
• RANKL-induced actin ring organization in mature OCs (2012, Mus musculus,Homo sapiens)
• A6B4 integrin regulation of A3 and A2 integrin expression (2012, Homo sapiens)
• Wnt/Beta-Catenin signaling pathway and their inhibitors (2012, Homo sapiens)
• Notch signaling pathway and their inhibitors (2012, Homo sapiens)
• Hh signaling pathway and their inhibitors (2012, Homo sapiens)
• Effect of sodium ferulate on caspase cascade apoptosis and IKK/NFKB pathways induced by TNF/TNF receptor (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Postulated model for regulation of large luteal cells of ruminants (left) and primates (right) (2012, NA)
• T cell signaling pathway used by A2 and A9 (2012, NA)
• SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice (2012, NA)
• Protective and pathogenic functions of Th17 cells (2012, NA)
• mTOR signaling pathway (2012, Human gammaherpesvirus 4,Human papillomavirus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• TLR-4 signaling in cancer (2012, NA)
• Proposed model by which A2B1 integrin mediates doxorubicin resistance in T-ALL cells (2012, NA)
• Schematic diagram showing the role of NDRG1 in inhibiting the EMT via regulation of the TGFB/SMAD and Wnt pathways (2012, NA)
• Proposed mechanistic link between Por deletion and up-regulation of MHC II expression in enterocytes (2012, NA)
• ROS generation in innate immune signaling (2012, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Pseudomonas aeruginosa,PX clade,Enterococcus faecalis,Homo sapiens,Mus musculus)
• JAK-STAT pathway in hypertrophic stress signaling and genomic stress response (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• JAK-STAT pathway in hypertrophic stress signaling and genomic stress response (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• JAK-STAT pathway in hypertrophic stress signaling and genomic stress response (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Roles of STATs signaling in cardiovascular diseases (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Differential STAT3 signaling in the heart (2012, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens)
• STAT1 as a central mediator of IFNG and TLR4 signal integration in vascular dysfunction (2012, Homo sapiens,Mus musculus,Drosophila melanogaster,Diaporthe sclerotioides,Listeria monocytogenes)
• JAK-STAT pathway and hematopoietic stem cells from the JAK2 V617F perspective (2012, NA)
• Functions of the Drosophila JAK-STAT pathway (2012, NA)
• Ubiquitin-mediated regulation of JAK-STAT signaling in embryonic stem cells (2012, NA)
• Infection-induced IL-10 and JAK-STAT (2012, NA)
• Spectrum of STAT functions in mammary gland development (2012, NA)
• STAT3 regulation of and by microRNAs in development and disease (2012, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Hepatitis B virus,Homo sapiens)
• Signaling pathways involved in head and neck cancer (2012, NA)
• FGF signaling cascades, an example of RTK signaling (2012, NA)
• Canonical (left) and noncanonical (right) WNT signaling pathways (2012, NA)
• Sonic hedgehog (SHH) signaling pathway (2012, NA)
• BMP signaling pathway and regulation of SMAD activity (2012, NA)
• Notch pathway (2012, NA)
• Interaction map showing potential links between the Par proteins and components of the Hippo pathway (2012, NA)
• Wnt signaling pathways (2012, NA)
• Wnt signaling at vertebrate neuromuscular junctions (2012, NA)
• ATM/ATR DNA-damage response pathway (2012, NA)
• Comparative Genomic Analysis of Soybean Flowering Genes (2012, Arabidopsis thaliana,Oryza sativa,Glycine max,Hordeum vulgare,Medicago truncatula,Brachypodium distachyon,Lotus japonicus,Glycine soja,Arabidopsis lyrata,Homo sapiens,Pseudomonas phage PRR1)
• Proposed mechanisms of leptin and glucocorticoid stress hormones in the GSK3B/Beta-catenin signaling pathway (2012, NA)
• Cross-talk between muscle (pink) and tendon (dark grey) cells in Drosophila (2012, NA)
• In young muscle, abundant serum IGF-I can stimulate protein synthesis by activating Akt/mTOR/p70S6K pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Multi-scale model of the immune response to Mtb infection in the lung (2012, Homo sapiens,Mus musculus,Cavia porcellus,Macaca fascicularis,Mycobacterium tuberculosis,Morchella esculenta,Rutilus frisii)
• Functional interaction network analysis of genes with enriched expression (EE) and differential splicing (DS) in the placenta (2012, Homo sapiens,Mus musculus,Platanus racemosa)
• Schematic diagram showing the putative TGFB signaling pathways involved in EndoMT (2012, NA)
• Postprandial Regulation of Hepatic MicroRNAs Predicted to Target the Insulin Pathway in Rainbow Trout (2012, Danio rerio,Oncorhynchus mykiss,Oryzias latipes,Salmo salar,Salmo trutta,Paralichthys olivaceus,Takifugu rubripes,Tetraodon nigroviridis,Gasterosteus aculeatus,Lates calcarifer,Hypophthalmichthys nobilis,Hippoglossus hippoglossus,Hypophthalmichthys molitrix,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of DCs in the pathogenesis of GVHD (2012, NA)
• Pathway diagram of the cyanobacterial core metabolic network (2012, NA)
• Summary diagram of the proposed adrenomedullin (ADM) signaling pathway in the retina (2012, NA)
• BMPs and SHH cooperatively provide favorable circumstances for the growth and/or survival of prostate cancer cells and the differentiation of stromal cells (2012, Homo sapiens,Mus musculus)
• Partial representation of triacylglycerol and glycerophospholipid metabolism related to synthesis and digestion of glycerol 3-phosphate (2012, NA)
• The ARF6 signaling pathway involved in HLHCGR internalization as deduced from the present study (2012, NA)
• Proposed model of Fas-mediated death of photoreceptors under light stress (2012, Homo sapiens,Mus musculus)
• Somatic Activating PIK3CA Mutations in CLOVES Syndrome(A) Demonstration of the PIK3CA c.1624G>A somatic mosaic mutation in participant CL4 (2012, Syzygium aromaticum)
• Biosynthetic pathway for alanine (2012, Corynebacterium glutamicum)
• The regulation of proinflammatory cytokine and chemokine production by MAPKs in THP-1 cells (2012, Homo sapiens,Shigella dysenteriae)
• Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response (2012, NA)
• Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response (2012, NA)
• Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response (2012, NA)
• Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response (2012, NA)
• Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies (2012, NA)
• Infection strategies of enteric pathogenic Escherichia coli (2012, NA)
• Genome-Wide Association for Sensitivity to Chronic Oxidative Stress in Drosophila melanogaster (2012, NA)
• miR-519d, miR-190, and miR-340 in the TGFB signaling pathway (2012, NA)
• Mechanisms underlying the biological effects of polyphenols (2012, Malus domestica,herbal medicine,Olea europaea,Arachis hypogaea,Fragaria x ananassa,Spinacia oleracea,Allium cepa,Theobroma cacao,Ginkgo biloba,Petroselinum crispum,Apium graveolens Dulce Group,Prunus domestica,Origanum vulgare,Vitis labrusca,Allium ampeloprasum,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Sus scrofa)
• Schematic model showing the events occurring in B cells latently infected with KSHV in the context of angiogenin and the consequences of silencing angiogenin or inhibiting PLCG activation by neomycin (2012, Human gammaherpesvirus 8)
• Simplified schematic presentation of HCV genotype 2a-mediated blocking of the insulin signaling pathway (2012, Homo sapiens,NA)
• Model depicting miR-155-mediated modulation of macrophage apoptosis (2012, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mus musculus,Homo sapiens)
• The two major signaling cascades operating in cancer, following overactivation of the INSR/IGF-IR signaling pathways (2012, NA)
• Schematic diagram showing the influence of fluoxetine on NCAM140 homophilic interaction-induced activation of Ras-MAPK pathway (2012, NA)
• Interstitial oedema elicited by extracellular trypomastigotes might offer a window of opportunity for infection of heart cells via the endothelin/kinin pathways (2012, Trypanosoma cruzi,Homo sapiens)
• How Ang-(1-7) via its Mas receptor might inhibit diabetes or high glucose-induced EGF receptor signalling and prevent vascular complications associated with diabetes and/or hyperglycaemia (2012, NA)
• Mechanism of OX1R-driven apoptosis (2012, NA)
• Beta-Arrestin-dependent endocytosis and signalling of GPCRs (2012, Allium tricoccum)
• Increased Levels of BAFF and APRIL Related to Human Active Pulmonary Tuberculosis (2012, Homo sapiens,Mus musculus,Mycobacterium tuberculosis)
• Caspase-8 has a crucial role in the regulation of DRs (2012, NA)
• Rho1 in cell wall remodeling, exocytosis, and cytokinesis (2012, NA)
• SHRC interaction with retromer on membranes (2012, Saccharomyces cerevisiae,Arabidopsis thaliana,Armoracia rusticana,Bikinia letestui,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Tobacco etch virus)
• Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• MTOR signalling pathway (2012, Homo sapiens,Neotragus moschatus)
• TRAF-6 Dependent Signaling Pathway Is Essential for TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Osteoclast Differentiation (2012, NA)
• Comparison of the pathways responsible for the anti-apoptotic and pro-apoptotic effects of immune complexes containing oxidized LDL (oxLDL-IC) and malondialdehyde-modified LDL (MDA-LDL-IC) (2012, NA)
• PI3K/Akt/GSK-3/Beta-catenin pathway activation in fluid shear-stressed osteoblasts (2012, NA)
• Iron-mediated redox modulation in neural plasticity (2012, NA)
• IL-2 release by DCs stimulation of PRRs triggers the calcineurin/NFAT pathway via PLCG2 and intracellular Ca2+ flux (2012, NA)
• HER2 signaling pathway (2012, Homo sapiens,Mus musculus)
• Signal transduction pathways of the amino acid (AA) response (AAR) (2012, NA)
• T-cell development and differentiation (2012, NA)
• MyD88 signal pathway (2012, NA)
• TRIF signal pathway (2012, NA)
• A Human Homeotic Transformation Resulting from Mutations in PLCB4 and GNAI3 Causes Auriculocondylar Syndrome (2012, NA)
• Core components of the canonical Notch signaling pathway in Drosophila (2012, NA)
• Proposed Model of Psoriasis Pathogenesis in the Presence of Psoriasis-Specific CARD14 AlterationsAfter an inflammatory trigger, alterations in CARD14 induce activation of NF-kB (2012, NA)
• Logic of TGFB signalling from the membrane to nucleus (2012, NA)
• NK cells sense tumors, course of disease and treatments (2012, NA)
• Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression (2012, NA)
• TGFB and Iron Differently Alter HBV Replication in Human Hepatocytes through TGFB/BMP Signaling and Cellular MicroRNA Expression (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Hepatitis B virus,Hepatitis delta virus,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Meleagris gallopavo,NA)
• Prototypical angiogenic cytokine signalling pathways invoking endogenous NO production and subsequent kinase cascade activation (2012, NA)
• PKA-dependent signalling pathway is activated by various stimuli (e.g (2012, NA)
• Host immune response to viral infection (Interferon Signaling Pathways) (2012, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Vesicular stomatitis virus,Homo sapiens,Mus musculus,NA)
• Schema of the possible roles of Trp-His on CaMK II-mediated VDCC phosphorylation in VSMCs (2012, NA)
• Tamarindus indica Extract Alters Release of Alpha Enolase, Apolipoprotein A-I, Transthyretin and Rab GDP Dissociation Inhibitor Beta from HepG2 Cells (2012, Tamarindus indica,Homo sapiens)
• Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing (2012, NA)
• Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut (2012, NA)
• p16-Cdk4-Rb signaling pathway diagram (2012, NA)
• Retinoid metabolic pathway (2012, NA)
• The Drosophila IMD and mammalian TNF signalling pathways (2012, Drosophila melanogaster,Homo sapiens)
• Relationship between binding of ligands to the pattern recognition AGE receptor (RAGE) and inflammation, gene expression, oxidative and nitrosative stress, and damage to the macro- and microvasculature (2012, NA)
• Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment (2012, Homo sapiens)
• Flow diagram showing the major key factors involved in the pathogenesis of DR and the clinical symptoms evident at different stages of DR (2012, Canis lupus familiaris,Sus scrofa,Felis catus,Panthera leo,Homo sapiens,Macaca mulatta,Macaca fascicularis,Mus musculus,Rattus norvegicus,Dipturus trachyderma)
• Analysis of the cell cycle pathway (2012, Homo sapiens)
• Unfolded protein response (UPR) (2012, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Homo sapiens,Bos taurus,prion,NA)
• Complete staphyloxanthin biosynthetic pathway, gene cluster organization, and reconstructed staphyloxanthin pathway in heterologous host E (2012, NA)
• Proposed model for hYAP regulation in response to SN2 alkylating agents (2012, NA)
• Major mechanisms of immune modulation by tolerogenic DCs (2012, Homo sapiens,Mus musculus)
• Proposed model for the role of the IGF-1R/NFKB signaling pathway in regulating the caspase-3 differentiation initiation signal (2012, Gallus gallus,Homo sapiens)
• CSF arrest is the result of a tight balance between PP2A-B55 and PP2A-B56 (2012, NA)
• Two hypotheses for Gwl activation and mitotic entry (2012, NA)
• Pocket protein regulatory network is disrupted by multiple mechanisms in cancer (2012, NA)
• Distinct activation pathways for different CDKs (2012, NA)
• Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease (2012, Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease (2012, Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease (2012, Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes (2012, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Ingenuity Pathway Analysis of altered expression of proinflammatory genes in normal human melanocytes transduced with Ad-Slug (2012, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Peripheral Blood Transcriptome Identifies the Presence and Extent of Disease in Idiopathic Pulmonary Fibrosis (2012, NA)
• Mitochondria are central organelles in determining cell fate in liver diseases (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Equus caballus,Hepatitis B virus,NA)
• Mitochondria biogenesis allows tissue adaption under stress (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Equus caballus,Hepatitis B virus,NA)
• Molecular network of protein degradation, amino acid metabolism, and behavior for NC-treated cells in comparison with TC extract-treated cells (2012, NA)
• The role of Notch ligands in our models (2012, NA)
• GFPT1-mediated MTOR signaling pathway affected by glucose and fructose in a pTr cell line (2012, Bos taurus,Sus scrofa,Ovis aries,Homo sapiens)
• ERK signaling pathway controls T-cell activation and anergy (2012, NA)
• Th17 cells have stem cell-like features and promote long-term immunity (2012, Homo sapiens,Mus musculus)
• Colon cancer cells produce immunoregulatory glucocorticoids (2012, Homo sapiens,Mus musculus)
• Summary of the hypothesis (2012, NA)
• The mechanism through which PTPN22 blocks proapoptotic and enhances antiapoptotic BCR signals (2012, Rattus norvegicus,Homo sapiens)
• Cell growth on autophagy (2012, NA)
• Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches (2012, Homo sapiens,Mus musculus)
• Signaling pathways that regulate cytokine AREs post-transcriptionally (2012, NA)
• mTOR as a potential treatment target for epilepsy (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt/Beta-catenin signaling pathway (2012, Homo sapiens)
• Schematic depiction of NFKB signaling pathway highlighting FOXP1 target genes (2012, Homo sapiens,Mus musculus)
• Proposed model of signaling associated with Fst-mediated skeletal muscle hypertrophy (2012, Bos taurus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Adeno-associated virus,adeno-associated virus 2,Homo sapiens,Salmo trutta)
• UPR signaling in diseases (2012, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Human alphaherpesvirus 1,prion)
• MTOR signaling pathway (2012, Homo sapiens)
• CRLs/SCF E3 ubiquitin ligases regulate mTOR pathway (2012, Homo sapiens)
• The mTOR signaling pathway (2012, Homo sapiens)
• Role of Apoptosis in disease (2012, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Listeria monocytogenes,Streptococcus pneumoniae,Clostridioides difficile,Bacillus anthracis,Chlamydia trachomatis,Chlamydia pneumoniae,Aggregatibacter actinomycetemcomitans,Clostridioides difficile CD3,Clostridioides difficile CD8,Tropheryma whipplei,Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Human T-cell leukemia virus type I,Human alphaherpesvirus 3,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Paralvinella conceptual glutathione pathway and responses to thermal exposure (2012, Paralvinella palmiformis,Paralvinella sulfincola)
• The plasma proteins that regulate ionic gradients following neurotransmitter release or during the time course of an action potential spike (2012, NA)
• Chronic morphine decreases VTA DA soma size yet increases neuronal excitability, while DA transmission to NAc is decreased (2012, NA)
• Up-regulation of the cAMP pathway in LC as a mechanism of opiate tolerance and dependence (2012, NA)
• CD30 signals through TRAFs: upon stimulation by CD30L, CD30 recruits TRAF2 via interaction with its TRAF binding motif, resulting in TRAF2 degradation (2012, NA)
• Results from single pathway sets (2012, Homo sapiens,Saccharomyces cerevisiae)
• Hexosamine and acetyl-CoA metabolite levels integrate signaling with cell growth and proliferation (2012, Homo sapiens)
• Evolution of Wnt pathways (2012, NA)
• Gp130 mediated IL-6 family of cytokines signaling pathway (2012, NA)
• Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner (2012, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Schizosaccharomyces pombe 972h-,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Mus musculus,Escherichia coli,Xenopus laevis,vectors)
• IL-4 Engagement of the Type I IL-4 Receptor Complex Enhances Mouse Eosinophil Migration to Eotaxin-1 In Vitro (2012, Mus musculus,Rattus norvegicus,Bikinia letestui,Ambrosia artemisiifolia,Homo sapiens,Bos taurus,Gallus gallus,Schistosoma mansoni)
• AML Signalisome (2012, Homo sapiens,Caenorhabditis elegans)
• AhR-related signaling molecules are enriched within the AML Signalisome (2012, Homo sapiens,Caenorhabditis elegans)
• Engineering Yarrowia lipolytica to Produce Glycoproteins Homogeneously Modified with the Universal Man3GlcNAc2 N-Glycan Core (2012, Yarrowia lipolytica,Homo sapiens)
• miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes (2012, NA)
• miRNA-mRNA Correlation-Network Modules in Human Prostate Cancer and the Differences between Primary and Metastatic Tumor Subtypes (2012, NA)
• Dual Aspects of Altered Bone Remodeling in Psoriatic Arthritis (2012, Homo sapiens,Mus musculus)
• Mammalian Hippo pathway and cancer (2012, Homo sapiens)
• Antiinflammatory mechanisms of tissue-protective molecules (2012, Rattus norvegicus,Homo sapiens)
• Schematic pathway highlighting major events in mevalonate cascade inhibition-induced cell death in hATF: HMG-CoA inhibition with simvastatin concomitantly induces apoptosis, autophagy and UPR/ER stress in hATF (2012, NA)
• RIP1- and EDD-mediated pathway of TNFA production (2012, Mus musculus,Rattus norvegicus,Homo sapiens,vectors)
• Schema of the EGFR activation pathway (2012, NA)
• Association between sorafenib and the MAPK cascade (2012, Homo sapiens,Mus musculus,Armoracia rusticana)
• Shared biological pathway activation between chemotherapeutic agent treatments (2012, Homo sapiens,Mus musculus,Bos taurus,Taxus brevifolia)
• Common biological pathways activated in OVCA cells in response to chemotherapeutic agents (2012, Homo sapiens,Mus musculus,Bos taurus,Taxus brevifolia)
• Cytochrome c and mitochondrial dysfunction in AA-PCD pathways (2012, NA)
• Layers of DC-mediated tolerance (2012, NA)
• Canonical Hedgehog signaling (2012, NA)
• Flavonoid biosynthetic pathway in Arabidopsis seed (2012, Arabidopsis thaliana,Zea mays,Glycine max,Solanum lycopersicum,Malus domestica,Vitis vinifera,Brassica napus,Medicago truncatula,Fragaria x ananassa,Phaseolus vulgaris,Prunus dulcis,Rubus idaeus,Homo sapiens,Rattus norvegicus,Helicoverpa zea)
• Anti-Obesity Sodium Tungstate Treatment Triggers Axonal and Glial Plasticity in Hypothalamic Feeding Centers (2012, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Niche-Associated Activation of Rac Promotes the Asymmetric Division of Drosophila Female Germline Stem Cells (2012, NA)
• Regulation of KCNQ channels function by the Gq signaling pathway (2012, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Cavia porcellus,Mustela lutreola,Drosophila melanogaster,Paracentrotus lividus,Homo sapiens,Arabidopsis thaliana,Xenopus laevis)
• EP receptors: types and signalling (2012, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human immunodeficiency virus,Listeria monocytogenes)
• Signaling pathway involving CaMKK regulation of GluA1 synthesis and synaptic incorporation as CP-AMPARs (2012, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Diaporthe sclerotioides)
• Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways (2012, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Vibrio cholerae,Clostridioides difficile,Pseudomonas aeruginosa PAO1,Bacillus thuringiensis,Escherichia coli OP50,Burkholderia pseudomallei,Pseudomonas aeruginosa PA14,Escherichia coli 53A,Homo sapiens,Mus musculus,Caenorhabditis elegans,Malus domestica,Amphilophus globosus)
• Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells (2012, Homo sapiens)
• Diaminopimelate/lysine biosynthesis pathways (2012, Verrucomicrobium spinosum,Homo sapiens)
• Main pathway disorders leading to muscle proteolysis, atrophy, hypoxia and anti-oxidant response (2012, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Diaporthe sclerotioides,Xenopus laevis,Homo sapiens,Escherichia coli,Equus caballus)
• TZD action in osteocytes (2012, NA)
• Multifunctional roles of glucose metabolism (2012, NA)
• Formation of the COPII vesicle on the surface of the endoplasmic reticulum (2012, NA)
• Important molecules involved in negative immune regulation (2012, NA)
• Impact of a negative regulator on pathogenesis and the development of sepsis, secondary to acute insults (2012, NA)
• Illustration of the strain-dependent alterations in STEP phosphorylation and proteolysis following mechanical stretch injury via the NMDAR and calcineurin pathways (2012, Rattus norvegicus,Homo sapiens)
• Defence Signalling Triggered by Flg22 and Harpin Is Integrated into a Different Stilbene Output in Vitis Cells (2012, Arabidopsis thaliana,Nicotiana tabacum,Zea mays,Solanum lycopersicum,Malus domestica,Vitis vinifera,Botrytis cinerea,Pyrus communis,Petroselinum crispum,Peronospora farinosa,Plasmopara viticola,Solanum peruvianum,Vitis rupestris,Diplodia sapinea,Pseudomonas syringae,Erwinia amylovora,Dickeya chrysanthemi,Pseudomonas savastanoi pv. phaseolicola,Mus musculus,Capra hircus,Homo sapiens)
• RAS Protein in EGFR Signaling Pathway (Source: Medscape General Surgery) (2012, NA)
• An example pathway (2012, Homo sapiens,Saccharomyces cerevisiae)
• Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype (2012, NA)
• Dark face of AMPK as an essential tumor promoter (2012, NA)
• Control of perineural and cortex glia proliferation in the Drosophila larval brain (2012, NA)
• Chemical structures of PSI-352938 and its potential metabolites and the proposed metabolic pathway of PSI-352938 activation (2012, Homo sapiens,NA)
• Shp2 Activates Fyn and Ras to Regulate RBL-2H3 Mast Cell Activation following FcERI Aggregation (2012, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Escherichia coli DH5alpha)
• New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic Beta-cells (2012, NA)
• New insight into the mechanisms underlying the function of the incretin hormone glucagon-like peptide-1 in pancreatic Beta-cells (2012, NA)
• Yeast Magmas Ortholog Pam16 Has an Essential Function in Fermentative Growth That Involves Sphingolipid Metabolism (2012, NA)
• Cytoskeleton remodeling signaling, an example of a differentially regulated pathway in the motor cortex of SALS (2012, NA)
• (a–c) Fungal-derived resorcyclic acid lactones: (a) hypothemycin and zearalenone; (b) the monocillins; (c) RAD, pochonin A and pochonin D, chlorinated forms of the monocillins that are inhibitors of Hsp90 (2012, NA)
• Sample gene regulatory network (2012, NA)
• Developmental Changes in the Metabolic Network of Snapdragon Flowers (2012, Arabidopsis thaliana,Nicotiana tabacum,Embryophyta,Magnoliopsida,Beta vulgaris,Antirrhinum majus,Dianthus caryophyllus,Calendula officinalis,Rosa hybrid cultivar,Clarkia breweri,Portulaca grandiflora)
• Leptin and cancer: Pathogenesis and modulation (2012, Homo sapiens,Mus musculus)
• Leptin/Ob-Rb binding results in insulin receptor substrate (IRS) phosphorylation, which in turn activates PI3K/AKT pathway through the association of IRS with the regulatory subunit p85 of AKT (2012, Homo sapiens,Mus musculus)
• Developmental Changes in the Metabolic Network of Snapdragon Flowers (2012, Arabidopsis thaliana,Nicotiana tabacum,Embryophyta,Magnoliopsida,Beta vulgaris,Antirrhinum majus,Dianthus caryophyllus,Calendula officinalis,Rosa hybrid cultivar,Clarkia breweri,Portulaca grandiflora)
• The proteins involved in the different pathways related to eicosanoid biosynthesis (2012, NA)
• Schematic showing observed protein level alterations in VSCC proteome in the context of HPV infection (2012, Human papillomavirus)
• The quantitative system pharmacology approach for a schizophrenia model is based on actual preclinical neurophysiology and human neuroanatomy (2012, NA)
• Toll-like receptor signaling pathway figure supplied by KEGG ] (2012, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,West Nile virus,Murid betaherpesvirus 1,Human betaherpesvirus 6,Bovine alphaherpesvirus 1,Vicia sativa,Vicia sativa subsp. nigra,Homo sapiens,Mus musculus,Bos taurus,NA,NA)
• Roles of Platelets and the Signal Transductions Identified as the Major Cascades in Hepatocyte Proliferation (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Glycolytic pathway and its metabolic interconnection with the pentose-phosphate pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Human papillomavirus)
• TLR signaling (2012, NA)
• Simulated Microgravity on Human Umbilical Vein Endothelial Cell Angiogenesis and Role of the PI3K-Akt-eNOS Signal Pathway (2012, NA)
• Protein kinase A and fungal virulence (2012, NA)
• Metabolic fluxes upon different carbon sources (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Camelus bactrianus)
• (A,B) Modulation of host defense-signaling networks by pathogen effectors (2012, NA)
• Regulation of presynaptic Cav channels by GSK-3 (2012, NA)
• Summary of ion channel targets of the GSK-3 pathway (2012, NA)
• Viral genes and the activation of apoptosis (2012, NA)
• Map of the VEGF signaling pathway (as an example of an important target in cancer therapy) obtained from KEGG is shown (2012, Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,Lambdavirus lambda)
• Possible molecular mechanisms of Ngb neuroprotection by modulating cell death/survival signaling pathways (2012, NA)
• LPA-LPAR1/3 GAi2–mediated activation of p130Cas in cell migration (2012, NA)
• Schematic presentation of signaling pathways and their downstream targets that are affected by a feedback loop between hBVR and PKCD (2012, NA)
• Signaling pathways that regulate cAMP-mediated WPB exocytosis (2012, NA)
• MicroRNA Profiling in Mucosal Biopsies of Eosinophilic Esophagitis Patients Pre and Post Treatment with Steroids and Relationship with mRNA Targets (2012, Homo sapiens,Mus musculus,Helicobacter pylori,Sequoia sempervirens)
• Control of MDSC by cytokines (2012, NA)
• MAPK Pathways in S (2012, Saccharomyces cerevisiae,Homo sapiens)
• Mating, Filamentous Growth, and Virulence in U (2012, Saccharomyces cerevisiae,Homo sapiens)
• FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage (2012, NA)
• Pathogenicity Pathway from M (2012, Saccharomyces cerevisiae,Homo sapiens)
• Loss of Activating EGFR Mutant Gene Contributes to Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in Lung Cancer Cells (2012, Homo sapiens,Bos taurus,Armoracia rusticana,clinical samples)
• TGFB signaling pathway (2012, NA)
• MAPK pathways and Proteasome inhibitors (2012, Human gammaherpesvirus 4,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus)
• RAS/PI3K/mTOR/STAT3 signaling (2012, Homo sapiens,Mus musculus,Bos taurus)
• IGF-IR signaling pathway (2012, Homo sapiens,clinical samples)
• “Hpo signaling pathway in Mammals and the cross-talk with RASFF1A signaling.” Schematic representation of mammalian Hippo kinases cascade and interconnections between Hippo pathway and rassf1a protein signal (2012, Gallus gallus,Lareunionomyces loeiensis,Turdus migratorius,Eragrostis tef,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Regulation of apoptosis by several pathways (2012, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Simple model for regulation of breast cancer initiating cells (BT-IC) self-renewal in breast cancer (2012, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Metabolic signaling regulation (2012, NA)
• Signaling pathways regulating autophagy and their inhibitors (2012, NA)
• Gene expression alterations in Rocky Mountain elk infected with chronic wasting disease (2012, Bos taurus,Odocoileus virginianus,Odocoileus hemionus,Homo sapiens)
• Significantly differentially expressed genes identified by KEGG as involved in toll-like receptor signaling (2012, Danio rerio,Oncorhynchus mykiss,teleost fish,catfish,Larimichthys crocea,Scophthalmus maximus,Lateolabrax japonicus,Oplegnathus fasciatus,Abramis brama,Ictalurus furcatus,Mycobacterium tuberculosis,Listeria monocytogenes,Brucella abortus,Aeromonas hydrophila,Vibrio harveyi,Mycobacterium marinum,Edwardsiella tarda,Aeromonas salmonicida,Viral hemorrhagic septicemia virus,Infectious spleen and kidney necrosis virus,Candida albicans 18E,Candida albicans 24E,Homo sapiens,Mus musculus,NA)
• PGI2signaling pathways in VSMCs (2012, Rattus norvegicus,Homo sapiens)
• PGI2 metabolism and vascular disorders in premature and full-term newborn (2012, Rattus norvegicus,Homo sapiens)
• PTHrP signaling pathways during endochondral ossification (2012, NA)
• TRAF6 and TRAF2/5 signaling pathways (2012, NA)
• Possible key signaling components in the force-mediated stem cell differentiation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Functional interaction sub-network constructed by using module 2 genes (2012, Homo sapiens,Saccharomyces cerevisiae,Turdus migratorius)
• Biased signaling of mGlu1a receptors (2012, NA)
• The regenerating islet-derived type IV signaling pathway (2012, NA)
• Model depicting PI3K signaling (2012, NA)
• Fueling and imaging brain activation (2012, Rattus norvegicus,Homo sapiens)
• Models for the repair of DNA double-strand breaks (2012, Homo sapiens,Saccharomyces cerevisiae)
• Rad51 filament formation and regulation (2012, Homo sapiens,Saccharomyces cerevisiae)
• Mammalian target of rapamycin (mTOR) pathway regulates T-cell activation, differentiation and migration (2012, NA)
• Control of ATM function by Pdk1-Foxo1 pathway (2012, NA)
• (Pro)renin Receptor Triggers Distinct Angiotensin II-Independent Extracellular Matrix Remodeling and Deterioration of Cardiac Function (2012, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Adenoviridae)
• Novel MicroRNAs Differentially Expressed during Aging in the Mouse Brain (2012, Drosophila melanogaster,Caenorhabditis elegans,Drosophila simulans,Schmidtea mediterranea,Drosophila pseudoobscura,Drosophila virilis,Drosophila mojavensis,Drosophila yakuba,Drosophila sechellia,Drosophila ananassae,Drosophila persimilis,Drosophila willistoni,Drosophila erecta,Drosophila grimshawi,Homo sapiens,Macaca mulatta,Pan troglodytes,Gorilla gorilla,Pongo pygmaeus,Macaca nemestrina,Pan paniscus,Ateles geoffroyi,Lagothrix lagotricha,Saguinus labiatus,Mus musculus,Rattus norvegicus,Bos taurus,Gallus gallus,Xenopus tropicalis,Monodelphis domestica)
• Regulatory changes in the pathway of flavonoid biosynthesis between female and male flowers (2012, Phoenix dactylifera,Homo sapiens)
• Proposed mechanistic model on how SHARPIN regulates TNF-induced NFKB activation through linear ubiquitination-mediated mechanisms (2012, NA)
• Proposed renin-induced signalling pathway in the NTS to regulate systemic blood pressure in WKY rats (2012, Rattus norvegicus,Homo sapiens)
• Pathway analysis (2012, NA)
• Networks generated by Ingenuity Pathway Analysis of the expression signature (2012, NA)
• Regulation of HCA3-induced ERK1/2 activation in A431 cells (2012, NA)
• Classical view of the RB pathway and RB function in mammalian cells (2012, NA)
• Necrosis signaling pathways (2012, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Agaricus bisporus,Homo sapiens,Mus musculus,NA)
• The molecular pathway regulating Xenopus lung development (2012, Homo sapiens,Xenopus laevis,unidentified)
• Identification of the HSPB4/TLR2/NFKB axis in macrophage as a therapeutic target for sterile inflammation of the cornea (2012, NA)
• Intracellular HIF-1A regulation pathway in normoxia and hypoxia (2012, NA)
• COP9 Signalosome Component JAB1/CSN5 Is Necessary for T Cell Signaling through LFA-1 and HIV-1 Replication (2012, Human immunodeficiency virus 1,Human immunodeficiency virus,Middle East respiratory syndrome-related coronavirus,Human T-cell leukemia virus type I,Human immunodeficiency virus 2,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,vectors)
• Whole Transcriptome Analysis of the Effects of Type I Diabetes on Mouse Oocytes (2012, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• PKA targets in myofibers (2012, Homo sapiens)
• GPCRs that induce myofiber hypertrophy (2012, Homo sapiens)
• Scheme for MKP-1-dependent regulation of Na+ reabsorption by hypotonic stress in renal epithelial A6 cells (2012, NA)
• RyR-dependent signaling pathway that mediates PCB-induced and activity-dependent dendritic growth (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Solanum lycopersicum,Mouse mammary tumor virus)
• PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation (2012, NA)
• Schematic diagram summarizing cAMP-mediated signaling in NS-1 cells (2012, NA)
• dsRNA receptor signaling pathways in dsRNA-sensitive and -resistant cells (2012, Homo sapiens)
• Ingenuity Pathway Analysis of proteins induced by DNP.A, overview of 15 specific functional networks, each of which contains 11 or more “focus” proteins (proteins that were significantly up- or down-regulated) (2012, NA)
• MTOR pathway and its interactions with other important pathways and cellular process relevant to cancer (2012, NA)
• Angiogenesis in tumor progression (2012, NA)
• Schematic diagram summarizing the known possible TrkB signalling pathways associated with neuronal plasticity (2012, NA)
• The processes included in the insulin model (2012, NA)
• Apoptosis pathway in Drosophila (2012, Danio rerio,Xenopus laevis,Dipturus trachyderma,Notophthalmus viridescens,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,unidentified)
• Distinct types of apoptosis-induced proliferation in Drosophila (2012, Danio rerio,Xenopus laevis,Dipturus trachyderma,Notophthalmus viridescens,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,unidentified)
• Models of apoptosis-induced proliferation in mammals (2012, Danio rerio,Xenopus laevis,Dipturus trachyderma,Notophthalmus viridescens,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,unidentified)
• Proposed signaling pathway of Tat-induced nuclear localization of ZO-1 in human brain endothelial cells (2012, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Clostridium botulinum)
• EGFR pathway in Drosophila (2012, NA)
• Segmentation clock oscillator (2012, NA)
• Conserved Wnt/Beta-catenin-dependent signaling pathway (2012, NA)
• Beta-Catenin-Dependent Wnt Signaling (2012, Homo sapiens,Caenorhabditis elegans)
• Restoration of cell death by ABT-737 in cancer cells that overexpress Bcl-2 and caspase activity is blocked (2012, NA)
• Schematic model showing role of AMPKA1 as an upstream kinase of TAK1 in TLR4-mediated signaling pathway (2012, Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,vectors)
• The role of FoxO1 in oxidative stress-induced apoptosis in mouse granulosa cells (2012, Homo sapiens,Mus musculus)
• Hypothetical model elucidating the regulation of phosphorylated FAK expression through an integrin A5 and B1-mediated MEK-ERK1/2-dependent pathway after ESWT (2012, Rattus norvegicus,Homo sapiens)
• Candidate miRNAs target genes involved in cell growth, survival, migration, and cell cycle progression (2012, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Eucalyptus intertexta,Homo sapiens,Caenorhabditis elegans,Danio rerio)
• Schematic outline of CD30 signaling and CD30 promoter induction by Ets-1–JunB in ALCL and HL (2012, NA)
• Ischemia/Reperfusion-Induced MKP-3 Impairs Endothelial NO Formation via Inactivation of ERK1/2 Pathway (2012, Armoracia rusticana,Salvia miltiorrhiza,Homo sapiens,Rattus norvegicus,Bos taurus)
• An NQO1-Initiated and p53-Independent Apoptotic Pathway Determines the Anti-Tumor Effect of Tanshinone IIA against Non-Small Cell Lung Cancer (2012, Mus musculus,Rattus norvegicus,herbal medicine,Salvia miltiorrhiza,Homo sapiens,Bos taurus,Calloplesiops altivelis)
• CXCL12/CXCR4 Axis Triggers the Activation of EGF Receptor and ERK Signaling Pathway in CsA-Induced Proliferation of Human Trophoblast Cells (2012, NA)
• Choline-releasing glycerophosphodiesterase EDI3 links the tumor metabolome to signaling network activities (2012, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Summary of pathways with differentially expressed genes comparing sarcomas to MSC in the current study (2012, NA)
• STAT3 signalling pathway in ALK+ ALCL (2012, NA)
• MEK/ERK signalling pathway in ALK+ ALCL (2012, NA)
• mTOR pathway (2012, Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Homo sapiens,Mus musculus,Gallus gallus,Streptomyces hygroscopicus)
• Summary of inhibitory effects of LY294002 on the PI3K/Akt signaling pathway and ABC transporters that characterize stem cells (2012, NA)
• Pathway in MAS and differentially expressed genes: as shown in Figure, IGSF4, PTPRC (CD45) and CD3D belong to a family of cell surface adhesion molecules (2012, Homo sapiens,Mus musculus,Meleagris gallopavo)
• PI3K/Akt signalling pathway in ALK+ ALCL (2012, NA)
• The molecular pathway required for NOD2-dependent autophagy (2012, Salmonella enterica subsp. enterica serovar Typhimurium)
• Proposed protective pathway by E-LP against glutamate-induced apoptosis in RGCs (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• A novel KRAS-initiated pathway leading to the activation of VMP1 in cancer cells (2012, NA)
• Glucocorticoid (GC) actions in the airways epithelium (2012, NA)
• Dengue Virus Infection Mediates HMGB1 Release from Monocytes Involving PCAF Acetylase Complex and Induces Vascular Leakage in Endothelial Cells (2012, NA)
• Bayesian regulatory network and optimal regulatory pathway of p42.3 protein (2012, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Mycobacterium tuberculosis)
• Proposed leptin signaling pathway in adipose Sca-1+/CD45-/CD34+MSC cells (2012, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Systems-level regulation of metabolic genes by Met TFs (2012, NA)
• Metabolic genes regulated by the Met TFs (2012, NA)
• Signal activation of human somatostatin receptor subtype-2 by membrane-displayed somatostatin (2012, NA)
• RhoA GTPase Switch Controls Cx43-Hemichannel Activity through the Contractile System (2012, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,Clostridium botulinum)
• Major known oxidant/antioxidant pathways in living organisms (2012, Homo sapiens,Nicotiana tabacum)
• Endoplasmic Reticulum Stress Stimulates p53 Expression through NFKB Activation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Moloney murine leukemia virus,Bellapiscis medius)
• Analysis of Central Metabolic Pathway Gene Expression with Compartmentalization Information.Heat maps in boxes indicate the expression of individual genes, and the chart plots indicate the aggregate expression levels of the pathway genes (2012, NA)
• There is a strong association between human papilloma virus (HPV) infection and the development of cancer formation because of viral immune evasion (2012, NA)
• Alarmins: awaiting a clinical response (2012, NA)
• Typical MAPK signaling pathway (2012, NA)
• Activation of the kallikrein-kinin system Top: The scheme depicts platelet-derived polyphosphates (PolyP) acting (intravascularly) as endogenous activators of the KKS (contact phase of coagulation) (2012, NA)
• ITIM-mediated signaling function of IDO (2012, NA)
• Broad receptor antagonism and attenuation of downstream signaling cascades mediated by decorin in tumor cells (2012, NA)
• Phosphatidylinositol 3-kinase (PI3K) pathway activation (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Immune cell types implied to be involved in celiac disease by pathway analyses (2012, Saccharomyces cerevisiae,Triticum aestivum,Hordeum vulgare,Avena sativa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Insulin signaling pathway (2012, Homo sapiens)
• Survival and proliferative effects of Dilong extract on RSC96 Schwann cell (2012, NA)
• CRM1 regulates the PI3K signaling pathway in MCL (2012, Homo sapiens)
• Major pathogenic lesions in MCL (2012, Homo sapiens)
• Structure and interacting partners of p62/SQSTM1 (2012, NA)
• p62/SQSTM1 acts either as a pro-oncogene or as a tumor suppressor protein (2012, NA)
• Autophagy and apoptosis: process and function (2012, NA)
• Pathways of autophagy induction by hypoxia and mutant RAS (2012, NA)
• Role of Akr1b7 in bile acids metabolism and signaling pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,unidentified)
• GPR30 activation of glutamate transporter function in astrocytes (2012, NA)
• Network pathways analysis of molecules identified in T-cells that are involved in LFA-1/ICAM-1 signaling (2012, NA)
• Formation and function of 16:1-PI in the signaling of the lipokine 16:1 in Swiss 3T3 cells (2012, Mus musculus,Homo sapiens)
• Modes of action of environmental risk factors for autism at excitatory synapses in the CNS (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Klebsiella pneumoniae,Felis catus,Pandanus tectorius)
• Binary-relation notation and key molecules of AlzPathway (2012, Homo sapiens,prion)
• Autocrine functions of VEGF in breast tumor cells (2012, Mus musculus,Homo sapiens)
• Interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility (2012, NA)
• Modular Nature of Dendritic Cell Responses to Commensal and Pathogenic Fungi (2012, NA)
• BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines (2012, NA)
• Amplifying phase (2012, NA)
• Homeostatic role of IFNy pathway and IFNy-dependence of IL2 pathway in heathy men (2012, NA)
• Cell-proliferative signaling pathways in lung tumors (2012, Homo sapiens)
• Principal platelet membrane receptors and signal transduction pathways (2012, Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Danio rerio,Antarctothoa delta,Petromyzon marinus,Homo sapiens,Oryctolagus cuniculus)
• This diagram of BCR/CD19-initiated signaling shows two key outcomes of PI3K activation (2012, Homo sapiens,Mus musculus,Staphylococcus aureus,Corynebacterium phage gamma)
• Atypical PKC signaling pathways leading to lymphocyte activation and/or differentiation (2012, Homo sapiens,Mus musculus)
• TGFB acting on stromal cells in the primary tumour promotes metastasis (2012, NA)
• Viral FLIPping Autophagy for Longevity (2012, NA)
• Differentially expressed genes within the Wnt Signalling pathway (2012, NA)
• Resveratrol Inhibits LPS-Induced MAPKs Activation via Activation of the Phosphatidylinositol 3-Kinase Pathway in Murine RAW 264.7 Macrophage Cells (2012, Armoracia rusticana,Arachis hypogaea,Brassica rapa,Aronia melanocarpa,Yucca schidigera,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Caenorhabditis elegans)
• GluN2AR- and GluN2BR-interacting signaling in neuronal survival and death (2012, NA)
• JAK-STAT signaling pathway (2012, NA)
• Bacterial nucleomodulins targeting chromatin (2012, NA)
• Three examples of chromatin-modifying complexes and their mode of action (2012, NA)
• TGFB signalling pathway (2012, NA)
• AKT signaling pathway (2012, NA)
• Illustration of the molecular signaling pathway of ER stress-induced cell apoptosis provoked by Beta-tubulin:CCTB complex destruction (2012, NA)
• Central role of USP18 in the regulation of type I IFN signaling pathways in pancreatic beta cells (2012, Human gammaherpesvirus 4,Dengue virus,Coxsackievirus,Coxsackievirus B5,Mus musculus,Rattus norvegicus,Bos taurus,Equus asinus,Homo sapiens)
• Various subnetworks of signaling molecules that regulate Golgi structure (2012, Bos taurus,Sus scrofa,Ovis aries,Saccharomyces cerevisiae,Drosophila melanogaster,Ricinus communis,Helix pomatia,Homo sapiens,Rattus norvegicus,Vesicular stomatitis virus,Triportheus paranensis)
• Protein network analysis of hits reveals multiple connections between signaling molecules and Golgi proteins (2012, Bos taurus,Sus scrofa,Ovis aries,Saccharomyces cerevisiae,Drosophila melanogaster,Ricinus communis,Helix pomatia,Homo sapiens,Rattus norvegicus,Vesicular stomatitis virus,Triportheus paranensis)
• Isolated central nervous system progression on Crizotinib (2012, Homo sapiens)
• Illustration of the expression levels of enzymes within the glycolytic pathway and major connections in the C (2012, Cryptosporidium parvum,Homo sapiens)
• Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis (2012, Homo sapiens)
• FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway (2012, Homo sapiens,Mus musculus)
• Signaling pathways driving mesenchymal stem cells to differentiate into lineages found in reparative disorders (2012, Homo sapiens,Mus musculus)
• Dysregulation of the cell cycle pathway during tumor progression (2012, Homo sapiens,Human immunodeficiency virus 1,Venustaconcha ellipsiformis)
• MiR-29 family is involved in multiple cellular processes (2012, Homo sapiens)
• NP1 level modulation by glucotoxicity in Beta-cells (2012, NA)
• Scheme of the Rho signaling canonical pathway identified in Ingenuity Pathway Analysis of the proteins with altered expression in both KO cell lines (2012, Mus musculus,Homo sapiens)
• A, Differential expression of proteins involved in glycolysis and TCA cycle (2012, NA)
• Regulatory effects of MDM2 on NFKB and p53 signaling pathways (2012, NA)
• Main signaling pathways involved in thyroid carcinogenesis are the MAPK and PI3K-AKT pathway (reproduced with permission) (2012, Homo sapiens)
• Proteins and protein isoforms in glycolysis/gluconeogenesis, TCA cycle, pentose phosphate pathway, galactose metabolism, and glutamine metabolism pathways (2012, Homo sapiens)
• Apoptosis and necrosis (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Representation of the “Interferon Signaling” and “Toll-like Receptor Signaling” pathways (2012, Homo sapiens,Macaca mulatta,Pan troglodytes,Macaca fascicularis,Chlorocebus aethiops,Callithrix jacchus,Gorilla gorilla,Hylobates sp.,Microcebus murinus,Cercocebus atys,Aotus trivirgatus,Chlorocebus sabaeus,Pongo abelii,Otolemur garnettii,Chlorocebus pygerythrus,Chlorocebus tantalus,Human immunodeficiency virus 1,Simian immunodeficiency virus,Simian immunodeficiency virus - agm,Mus musculus,Bos taurus,Escherichia coli,Canavalia ensiformis,NA,NA)
• Simplified carbon metabolic network (2012, Saccharomyces cerevisiae,Aspergillus niger,Komagataella pastoris,Ogataea angusta,Candida boidinii,Komagataella phaffii GS115,Hepatitis B virus,recombinant Hepatitis B virus,Homo sapiens,Mus musculus)
• Carcinogenesis of colorectal cancer cells and role of different miRNAs in cancer pathways (2012, NA)
• Central metabolic pathways of E (2012, Escherichia coli)
• Integrated functional association analysis of protein and genetic interactions on alanine and aspartate (2012, NA)
• 22C11-induced BACE1 accumulation and AB production in neurons (2012, NA)
• LCAT functions potentially affecting the pathogenesis of cardiovascular disease (2012, NA)
• Model describing the mechanisms of quercetin-induced cholesterol efflux in macrophages (2012, Armoracia rusticana,Malus domestica,Allium cepa,Ginkgo biloba,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Moloney murine leukemia virus)
• New metabolic retrograde signaling pathways (2012, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Embryophyta,Hordeum vulgare,PX clade,Brassica napus,Chlamydomonas reinhardtii,Pseudomonas syringae,Chlamydia trachomatis,Homo sapiens)
• Kaposi sarcoma-associated herpesvirus vGPCR broadly activates PI3K and MAPK pathways, leading to increased production of cytokines and growth factors, with a concurrent increase in cell proliferation, and inhibition of apoptotic pathways (2012, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Murid gammaherpesvirus 4,Saimiriine gammaherpesvirus 2,Homo sapiens,Mus musculus,NA)
• Kaposi sarcoma-associated herpesvirus K1 activates PI3K/AKT/mTOR signaling thereby activating protein synthesis and survival pathways, while inhibiting apoptotic pathways (2012, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Murid gammaherpesvirus 4,Saimiriine gammaherpesvirus 2,Homo sapiens,Mus musculus,NA)
• Metabolism of arachidonic acid (2012, NA)
• The phosphatase and tensin homolog deleted on chromosome ten (PTEN)/Akt pathway and its relationship to the androgen receptor (AR) based on the results of three papers published recently by the laboratories of Charles Sawyers, Damu Tang and Hong Wu (2012, NA)
• Initiation of the inflammatory response to monosodium urate crystals (MSU) by the innate immune system (2012, NA)
• EphA/ephrinA bidirectional signalling (2012, NA)
• Serine kinases involved in obesity-induced inflammation and insulin resistance (2012, Candida dubliniensis,Fraxinus berlandieriana,Homo sapiens,Mus musculus)
• Inhibition of insulin signaling pathway by SOCS1 and SOCS3 (2012, Candida dubliniensis,Fraxinus berlandieriana,Homo sapiens,Mus musculus)
• c-Mpl/TPO signaling pathway (2012, NA)
• Canonical Wnt signaling pathway (2012, NA)
• Ingenuity pathway analysis (IPA) top network that incorporates 9 genes identified as differentially methylated between methotrexate-naïve cases and controls by HM27 analysis (2012, NA)
• Pharamcologic activators and enhancers of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) (2012, NA)
• Pharmacologic inhibitors of the Wnt/Beta-catenin signaling pathway and known interactions with pathway components (see for references) (2012, NA)
• MAPK signaling to the translational machinery (2012, NA)
• MTORC2 signaling pathway (2012, NA)
• MTORC1 signaling to the translational machinery (2012, NA)
• PTEN acts as the endogenous antagonist of the PI3K-regulated growth pathway (2012, Homo sapiens)
• Actin cytoskeleton as a sensor and mediator of apoptosis (2012, NA)
• Proposed mechanism for MCME-mediated inhibition against migration of CL1 cells (2012, Momordica charantia,Homo sapiens)
• Antidepressant molecular targets based on the predominant PI3K/AKT/GSK3 pathways (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Porphyromonas gingivalis,Salvia rosmarinus)
• PI3K/AKT/GSK3/mTOR signaling (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Porphyromonas gingivalis,Salvia rosmarinus)
• Combinatorial Drug Discovery Using Transcriptional Response Modules (2012, Homo sapiens,Mus musculus,Bos taurus,NA)
• n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1 (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster,Dipturus trachyderma,Hepatovirus A)
• Role of the PI3K pathway in B cell antigen presentation functions (2012, NA)
• Alterations in the PI3K pathway in malignant B cells (2012, NA)
• AKT/mTOR signaling pathway (2012, NA)
• AKT/mTOR signaling and crosstalk with glycolysis and mitochondrial oxidative phosphorylation (2012, NA)
• Cartoon depicting the role of sialidases during the multistep process of myogenesis (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Mechanism of collagen gene regulation by scleraxis (2012, NA)
• Hodgkin lymphoma (2012, NA)
• Proposed UT-associated signaling pathways (2012, teleost fish,Dipnomorpha,Pelophylax ridibundus,Gillichthys mirabilis,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Canis lupus familiaris)
• Regulation of the FOXO3a survival, and glycolysis pathways under hypoxia in Spalax (2012, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Cryptomys hottentotus,Nannospalax ehrenbergi,Nannospalax galili,Nannospalax judaei,Muroidea,Homo sapiens,Candida dubliniensis)
• Scheme for relationships between exercise-associated hemodynamic changes, inflammatory response, and Hsp (2012, NA)
• General diagram of rapalogs, ATP-competitive mTOR inhibitors and dual AKT/mTOR pathway inhibitors that are clinical use (2012, NA)
• LECA Rabs and their proposed functions (2012, NA)
• Vicious spirals of repeating self-accelerating oxidative stress and dysregulated redox and information signaling as possible causes of type 2 diabetes (2012, NA)
• NFKB signalling pathway (2012, Theileria annulata,Homo sapiens)
• Two branches of the unfolded protein response (2012, NA)
• Wnt signaling component gene in kidney of WT and KLTG (2012, NA)
• Interleukin (IL)-13 and IL-4 signaling pathway (2012, NA)
• Transforming growth factor (TGF)B signaling pathway (2012, NA)
• Functional “DASE” networks (2012, Bos taurus,Nicotiana tabacum,Equus caballus,Matthiola incana,Homo sapiens,Mus musculus)
• Mathematical model of the apoptotic pathways induced by cisplatin (2012, Homo sapiens,Mus musculus)
• Characterization of the Phosphoproteome in SLE Patients (2012, Helicobacter pylori,Vitis vinifera,Escherichia coli IS1,Sarcandra glabra,Homo sapiens,Mus musculus)
• NFKB inhibition by A20 in the TNFR1 signaling pathway (2012, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Working Model of the Interplay between the Kennedy Pathway and the Lands Cycle.This model summarizes the major steps of the Kennedy pathway and the Lands cycle (2012, Arabidopsis thaliana)
• Combined etiopathogenesis of spina bifida (Shh: sonic hedgehog, Wnt: Wnt ligand in Wnt/B catenin signaling pathway, BMP: bone morphogenic protein, IGF: insulin-like growth hormone, and W: weeks) (2012, NA)
• Proposed model for the signaling pathway mediating NFKB activation induced by C-type lectin receptors (2012, NA)
• AmyloidB precursor protein (APP) processing pathway leading to AD (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Stagmomantis carolina)
• Central role of the cAMP pathway in amplifying and diversifying CRH-R signalling (2012, NA)
• Evolution of the PI3K-Akt pathway from a modular perspective: focusing on the role of the SH2 domains of p85 (2012, NA)
• Vasopressin signaling network (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis (2012, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Merluccius merluccius)
• Schematic representation of the HOG pathway (2012, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• RANK-mediated osteoclast cytoskeletal organization (2012, Mus musculus,Homo sapiens)
• LapADG signaling system (2012, Legionella pneumophila)
• TGFB latency, activation and signal transduction (2012, NA)
• Global Effect of Inauhzin on Human p53-Responsive Transcriptome (2012, NA)
• Resveratrol Prevents Ammonia Toxicity in Astroglial Cells (2012, NA)
• Chemokine Signaling Pathway from the KEGG database (ID: mmu04062) overlaid with log2 fold change values for genes differentially expressed between DBA/2 and C57BL/6 at day 14 (2012, NA)
• Mechanism of muscle protein synthesis inhibition by GCs (2012, Mus musculus,Homo sapiens)
• Generalized overview of the extrinsic and intrinsic apoptosis pathways (2012, Human gammaherpesvirus 4,Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,Human adenovirus sp.,Alphapapillomavirus 7,human papillomavirus 31,Poliovirus 1,Kappapapillomavirus 2,Homo sapiens,Mus musculus,Antarctothoa delta,NA)
• RIG-I/MAVS signaling pathway regulating hMPV-induced NFKB and IRF activation in airway epithelial cells (2012, NA)
• Toll-Like Receptors (TLR) signaling pathway involved in hMPV-induced gene expression in primary immune cells (2012, NA)
• Signaling network of astrocyte-synapse interactions (2012, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Molva molva,Mustela putorius furo,NA)
• Proposed metabolic pathways for central carbon and nitrogen metabolism in Y88 during glucose growth, based on protein identifications (dark gray ovals) and the presence of their corresponding genes in the Y88 genome (2012, NA)
• Two rapamycin-sensitive myogenic mTOR signaling pathways (2012, NA)
• Network of biglycan signaling in osteoblast differentiation and stabilizing role of biglycan in skeletal muscle (2012, NA)
• Neuropeptide GPCRs in C. elegans (2012, Drosophila melanogaster,Caenorhabditis elegans,Locusta migratoria,Periplaneta americana,Homo sapiens,Rattus norvegicus,Xenopus laevis,Beta vulgaris)
• Scaffolds KSR and Ste5 in MAPK signaling (2012, Mus musculus,Drosophila melanogaster,Caenorhabditis elegans,Xenopus laevis,Cricetus cricetus,Aphyosemion alpha,Homo sapiens,Saccharomyces cerevisiae)
• Mammalian N-end rule pathway.,,, N-terminal residues are indicated by single-letter abbreviations for amino acids (2012, NA)
• Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms (2012, NA)
• Detraining Differentially Preserved Beneficial Effects of Exercise on Hypertension: Effects on Blood Pressure, Cardiac Function, Brain Inflammatory Cytokines and Oxidative Stress (2012, NA)
• Up-regulated miR155 Reverses the Epithelial-mesenchymal Transition Induced by EGF and Increases Chemo-sensitivity to Cisplatin in Human Caski Cervical Cancer Cells (2012, NA)
• The proposed mechanism by which telmisartan improves insulin sensitivity in obese db/db mice (2012, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Zea mays,Homo sapiens,NA)
• Amniotic fluid stem cells to study mTOR signaling in differentiation (2012, NA)
• Genetic engineering approach for increasing Alpha-santalene production (2012, Saccharomyces cerevisiae,Homo sapiens)
• Rca1-dependent regulation of C (2012, NA)
• Postsynaptic receptors for AB oligomers affect different signaling pathways (2012, NA)
• Becoming a follicular or a MZ B-cell? (2012, Human gammaherpesvirus 4,unidentified influenza virus,Vesicular stomatitis virus,Staphylococcus aureus,Plasmodium falciparum,Haemophilus influenzae,Leishmania donovani,Homo sapiens,Mus musculus,Canis lupus familiaris,Lareunionomyces loeiensis,NA,NA)
• Toxicogenomic Analysis Suggests Chemical-Induced Sexual Dimorphism in the Expression of Metabolic Genes in Zebrafish Liver (2012, Homo sapiens,Mus musculus,Danio rerio)
• Proposed model for EA signaling (2012, Trypanosoma cruzi,Homo sapiens)
• Construction of the regulatory networks associated with the selected genes using IPA® database (2012, NA)
• Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Upstream regulators of the Hippo pathway (2012, Homo sapiens)
• Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the Vegfr3 Gene in Lymphatic Endothelial Cells (2012, NA)
• Sensing the enemy (2012, Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Shigella flexneri,Treponema denticola,Homo sapiens,Mus musculus)
• Bacterial effector targets the TRAF6-NFKB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells (2012, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Pseudomonas syringae,Shigella flexneri,Pasteurella multocida,Mus musculus,Cavia porcellus,Homo sapiens)
• Full network comparison of the original canonical pathway and the inferred cell-type-specific pathway (2012, Homo sapiens)
• TAp73-Mediated the Activation of C-Jun N-Terminal Kinase Enhances Cellular Chemosensitivity to Cisplatin in Ovarian Cancer Cells (2012, Homo sapiens,Bos taurus)
• Possible inflammatory signaling pathway that results from the functional associations of the identified inflammation-related proteins (marked with an underline), which is regulated by acupuncture in asthma (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Capra hircus)
• Simplified scheme of the mitogen-activated protein kinase (MAPK) (RAS-RAF-MEK-ERK) signaling pathway.Notes:BRAF and NRAS are the most commonly mutated oncogenes in melanoma (2012, Homo sapiens,Mus musculus)
• Proposed molecular mechanisms mediating GRPR regulation of brain function (2012, NA)
• PI3K/AKT signaling pathway in Tregs (2012, NA)
• TGFB3 in two human skin cell types critical for wound healing (2012, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Capra hircus,Diaporthe sclerotioides,Homo sapiens)
• Intracellular “tug-of-war” determines T cell fate (2012, NA)
• Simultaneous Non-Negative Matrix Factorization for Multiple Large Scale Gene Expression Datasets in Toxicology (2012, Canis lupus familiaris,Pekania pennanti,Homo sapiens,Mus musculus,Sequoia sempervirens)
• Synergistic Cooperation between Methamphetamine and HIV-1 gsp120 through the P13K/Akt Pathway Induces IL-6 but not IL-8 Expression in Astrocytes (2012, NA)
• Part of the top canonical pathway affected by in vivo LPS administration into the human lung (2012, Homo sapiens)
• Apoptotic Cells through a Ligase-Independent Function (2012, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Block of Death-Receptor Apoptosis Protects Mouse Cytomegalovirus from Macrophages and Is a Determinant of Virulence in Immunodeficient Hosts (2012, NA)
• Cell death regulation: Signalling pathways and potential sites for pharmacological intervention (2012, NA)
• ILOCi detected genes from T1D and their maps in 'type I diabetes mellitus' pathway (2012, NA)
• ILOCi detected genes from CAD and their maps in 'cytokine-cytokine receptor interaction' pathway (2012, NA)
• ILOCi detected genes from BD and their maps in 'neuroactive ligand-receptor interaction' pathway (2012, NA)
• Central carbon metabolism pathways in E (2012, Escherichia coli,Homo sapiens)
• Biological pathways targeted for therapy in renal cell carcinoma based on a knowledge of the underlying genetic changes and downstream biological consequences (2012, Homo sapiens,clinical samples)
• Thyrotropin-releasing hormone signaling (2012, NA)
• Signaling pathways in the homologous up-regulation of the mouse GnRHR promoter by GnRH in gonadotrope and non-gonadotrope cells (2012, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Ovis aries,Homo sapiens,Drosophila melanogaster,Betapolyomavirus macacae)
• Canonical cAMP signalling pathway (2012, NA)
• Cyclin A2, Rho GTPases and EMT (2012, NA)
• R(h)oads to microvesicles (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Upstream events in BCR signaling (2012, NA)
• Cyclic AMP-mediated induction of Treg cells and suppression of effector T cells (2012, NA)
• Cyclic AMP elevation leads to induction of the SOCS-3 gene in VECs (2012, NA)
• Mechanisms of resistance due to MET/HGF pathway and potential interventional strategies (2012, NA)
• MET/HGF signaling and functional cross-talk with other pathways (2012, NA)
• MET oncogene and its signaling pathway (2012, Homo sapiens)
• Schematic presentation of the signalling pathway involved in isoprenaline-induced up-regulation of IL-6 production in NMCFs (2012, Mus musculus,Adenoviridae,Homo sapiens)
• Physiological signaling pathway of low peroxynitrite (2012, NA)
• Summary of the role of the mammalian target of rapamycin (mTOR) signaling pathway in the development of tuberous sclerosis complex (TSC) and inhibition by mTOR inhibitors (2012, NA)
• Summary diagram of Nrf2 and HIF1 stimulation in presence of oxidative stress (2012, NA)
• Assumed role of mitochondria, Ca2+, and ROS in neuronal excitotoxicity and epileptogenesis (2012, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Felis catus,Carica papaya,Nigella sativa,Homo sapiens)
• Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection (2012, NA)
• Extracellular regulation of satellite cell fate (2012, NA)
• 20-Hydroxyecdysone Protects against Oxidative Stress-Induced Neuronal Injury by Scavenging Free Radicals and Modulating NFKB and JNK Pathways (2012, Armoracia rusticana,Diaporthe sclerotioides,Hypericum perforatum,Achyranthes bidentata,Cyanotis arachnoidea,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing (2012, NA)
• Using Answer Set Programming to Integrate RNA Expression with Signalling Pathway Information to Infer How Mutations Affect Ageing (2012, NA)
• GPCR Canonical Signaling Pathways (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Human immunodeficiency virus 1,Moloney murine leukemia virus,Mandrillus leucophaeus,Empria multicolor,Escherichia coli,Lareunionomyces loeiensis,Tetronarce californica)
• Three IPA Canonical Signaling Pathways: CD40, IL-1, and Chemokine Signaling in TGFB1+LPS+IFNGamma-treated astrocytes (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Human immunodeficiency virus 1,Moloney murine leukemia virus,Mandrillus leucophaeus,Empria multicolor,Escherichia coli,Lareunionomyces loeiensis,Tetronarce californica)
• Top three networks of significantly associated molecules in TGFB1+LPS+IFNGamma-treated astrocytes (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Human immunodeficiency virus 1,Moloney murine leukemia virus,Mandrillus leucophaeus,Empria multicolor,Escherichia coli,Lareunionomyces loeiensis,Tetronarce californica)
• Plastid-localized amino acid biosynthetic pathways of Plantae are predominantly composed of non-cyanobacterial enzymes (2012, NA)
• Context-dependent effect of PI3K signaling on Treg development, differentiation and maintenance (2012, Homo sapiens,Mus musculus,Leishmania major)
• B-cell receptor signaling in CLL (2012, NA)
• Signaling within the JAK-STAT pathway in bovine monocytes and M (2012, Homo sapiens,Bos taurus)
• Proposed mechanism (2012, Mus musculus,Citrobacter rodentium,Aegle marmelos,Homo sapiens)
• Immune activation in the GBS UTI transcriptome comprises prominent cytokine-cytokine receptor signaling (2012, Escherichia coli,Streptococcus agalactiae,Homo sapiens)
• MAP kinase signaling and AKT/PI3K pathway (2012, NA)
• Interaction Map for PTMScan Direct: Akt/PI3K pathway reagent (2012, NA)
• TrkA signaling pathway (2012, NA)
• Nitric oxide counters ethylene effects on ripening fruits (2012, NA)
• Shock block for improved immunotherapy (2012, NA)
• Fast, Potent Pharmacological Expansion of Endogenous Hes3+/Sox2+ Cells in the Adult Mouse and Rat Hippocampus (2012, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens)
• Schematic presentation of the different mammalian MAP kinase pathways (2012, Influenza A virus,Dengue virus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• Molecular mechanisms of the pro- and anti-oncogenic properties of ERK3, ERK4, and MK5 (2012, Influenza A virus,Dengue virus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• 14-3-3 signaling canonical pathway from IPA (2012, NA)
• Scheme of the BK-mediated signals linked to MMP-9 expression and brain astrocytic migration (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Cerobasis alpha)
• Alkylphospholipid (ODPC)-induced raft-based inhibition of cell signaling (2012, NA)
• Summary of the signaling pathways of PKMζ-mediated late-LTP (2012, NA)
• Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal SH-SY5Y Cells (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Escherichia coli,Pan troglodytes,Escherichia coli 27A,Danio rerio)
• Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses (2012, NA)
• The Evolution and Origin of Animal Toll-Like Receptor Signaling Pathway Revealed by Network-Level Molecular Evolutionary Analyses (2012, NA)
• Representation of the major players in the ceramide metabolism pathways (2012, Crassostrea gigas,Homo sapiens)
• MK5 is implicated in VEGF-mediated angiogenesis (2012, Influenza A virus,Dengue virus,Homo sapiens,Mus musculus,Nicotiana tabacum)
• Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression (2012, NA)
• Proposed model of FGF23 signaling in proximal tubular cells (2012, NA)
• Schematic depiction of the role of the retromer complex in mediating endosomal protein sorting (2012, NA)
• Global regulatory network model of energy-converting pathways (2012, Methanosarcina acetivorans)
• Protein kinase CD (PKCD) activation by proteolytic cleavage downstream of tumor necrosis factor (TNF) signaling in dopaminergic neurons (2012, NA)
• Interaction loop between the EGFR signaling pathway and miR-221/222 expression in the modulation of cellular processes (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Expression data mapped onto the KEGG pathway network (2012, NA)
• Proposed models for the release of apoptogenic proteins from the mitochondrial inter-membrane space mediating the mitochondrial death decision (2012, NA)
• Changes in the Plasmodium falciparum redox flux network after MB drug action.Notes: Results incorporating the transcription data and experimental mRNA expression data nine hours after incubation with methylene blue are shown (2012, Plasmodium falciparum,Homo sapiens)
• Retinoid refractoriness due to phosphorylation of retinoid X receptor alpha (RXR A), and its restoration by acyclic retinoid (ACR) in liver carcinogenesis (2012, NA)
• Activation of IGF-2R stimulates cardiomyocyte hypertrophy in the late gestation sheep fetus (2012, Rattus norvegicus,Ovis aries,Homo sapiens)
• AMPK is phosphorylated and activated by LKB1 in response to an increasing cellular AMP:ATP ratio (which reflects a decrease in energy supply) (2012, NA)
• Proposed signalling model of the essential role of PI3KG in MCP-1-stimulated aortic smooth muscle cell as an amplifier of PDGF-induced cell migration (2012, NA)
• DP1 regulates the Wnt pathway both negatively and positively (2012, Xenopus laevis,Homo sapiens)
• Screening the Budding Yeast Genome Reveals Unique Factors Affecting K2 Toxin Susceptibility (2012, NA)
• CTGF Increases IL-6 Expression in Human Synovial Fibroblasts through Integrin-Dependent Signaling Pathway (2012, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,Armoracia rusticana)
• Class I PI3K/Akt/mTOR axis pathway (2012, NA)
• GeneGo “Cell Adhesion_ECM remodeling” pathway map (2012, NA)
• Interplay between Smoking-induced Genotoxicity and Altered Signaling in Pancreatic Carcinogenesis (2012, Homo sapiens,Nicotiana tabacum)
• Genome sequences of wild and domestic bactrian camels (2012, NA)
• P53 signaling pathway: In normal conditions (black arrows), p53 is maintained at very low levels (2012, NA)
• Schematic diagram is a hypothetical depiction of the H3 receptor-mediated signalling pathways in the CNS and their probable implications (2012, NA)
• Intracellular trafficking proteins involved in CMT neuropathy (2012, NA)
• DNA repair pathways and implicated proteins (2012, NA)
• Insulin resistance in chronic kidney disease (2012, NA)
• Synthesis of nitric oxide and transduction cascades (2012, NA)
• Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice (2012, NA)
• PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development (2012, Caenorhabditis elegans,Homo sapiens)
• Ingenuity pathways analysis summary (2012, unidentified influenza virus,Porcine reproductive and respiratory syndrome virus,Porcine circovirus 2,Porcine respiratory coronavirus,Lelystad virus,PRRSV VR2332,Bos taurus,Sus scrofa,Matthiola incana,Sequoia sempervirens,Salmonella enterica,Streptococcus suis,prion,Homo sapiens)
• Schematic representation depicting A; the protein synthesis pathway in skeletal muscle involving the mammalian target of rapamycin complex 1 (mTORC1) (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Candida dubliniensis)
• IPA generates IL-17C interactome (2012, Homo sapiens)
• ALARM network and RAF signaling pathway (2012, NA)
• Most enriched molecular networks showing interactions between the significant genes (according to SAM)—(a) FOSB, ERK, MAPK3, CYR61, and the RAS-genes; (b) DUSP1, ERK1/2, P38MAPK, DUSP9, and RASD1; (c) CYR61 and NFRKB (2012, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,Drosophila melanogaster)
• The prolactin signaling network in NetSlim (2012, NA)
• Network of 25 target genes and their interactive genes involved in regulating apoptosis and autophagy (2012, NA)
• Metabolic adaptations drive acquired drug resistance in breast cancer cells (2012, Homo sapiens)
• Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine (2012, NA)
• Gene Expression Profile of Peripheral Blood Lymphocytes from Renal Cell Carcinoma Patients Treated with IL-2, InterferonA and Dendritic Cell Vaccine (2012, NA)
• Scheme of proposed signaling pathway used by bradykinin to stimulate proliferation in A498 cells (2012, NA)
• Design of chimeric Embden-Meyerhof (EM) pathway (2012, Escherichia coli,Zymomonas mobilis,Thermus thermophilus,Thermotoga maritima,Pyrococcus furiosus,Saccharolobus solfataricus,Archaeoglobus fulgidus,Thermococcus kodakarensis,Lactobacillus delbrueckii,Pyrococcus horikoshii,Thermus thermophilus HB8,Thermosynechococcus vestitus BP-1,Thermoproteus tenax,Pyrococcus horikoshii OT3,Saccharomyces cerevisiae,Pisum sativum,Saccharomyces cerevisiae UC5,Homo sapiens,Bos taurus,vectors)
• Scheme depicting the different outcomes caused by the presence of progerin and prelamin in cells (2012, Homo sapiens)
• Roles of miRNAs in DNA damage response (2012, Homo sapiens)
• PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H1 receptor (2012, Respiratory syncytial virus,Human T-cell leukemia virus type I,Betapolyomavirus macacae,Human alphaherpesvirus 2,Mus musculus,Rattus norvegicus,Cavia porcellus,Cryptomeria japonica,Euonymus japonicus,Homo sapiens,Bos taurus)
• Model illustrating how nicotine plus a HFD could exacerbate HFD-induced hepatic steatosis in obese mice (2012, Homo sapiens,Mus musculus)
• The mechanism of vGPCR-mediated ARE-mRNA stabilization (2012, Human gammaherpesvirus 8)
• Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways (2012, NA)
• Molecular signaling cascades which normally control mTORC1 activity and may become dysregulated in B-cell lymphomas leading to aberrant mTORC1 signaling activation (2012, NA)
• Heparanase-mediated activation of ERK (2012, NA)
• Important roles of SFKs in G protein-coupled receptor-induced platelet activation (2012, Mus musculus,Homo sapiens)
• NuRD, differentiation, and Wnt in relation to Cdk2ap1 in a global context (2012, NA)
• Mitochondrial apoptosis pathway (2012, Mus musculus,Cricetulus griseus,Homo sapiens,NA)
• Transcriptomic Analysis of Echinococcus granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation (2012, NA)
• Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease (2012, NA)
• Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease (2012, NA)
• Protective effects of curcumin in APPswe transfected SH-SY5Y cells (2012, NA)
• Vitamin B12 Synthesis and Salvage Pathways Were Acquired by Horizontal Gene Transfer to the Thermotogales (2012, Limosilactobacillus reuteri,Sinorhizobium meliloti,Thermotoga maritima,Archaeoglobus fulgidus,Lactobacillus delbrueckii subsp. lactis,Halobacterium salinarum NRC-1,Cereibacter sphaeroides 2.4.1,Thermotoga sp. RQ2,Mesotoga prima,Thermosipho africanus,Fervidobacterium nodosum,Kosmotoga olearia,Petrotoga mobilis,Thermodesulfovibrio yellowstonii,Thermosipho africanus TCF52B,Kosmotoga olearia TBF 19.5.1)
• Transcriptional Changes Associated with Lack of Lipid Synthesis in Parasitoids (2012, NA)
• Model summarizing the role of netrin-1 in the regulation of inflammation and albumin uptake in proximal tubular epithelial cells of the diabetic kidney (2012, Mus musculus,Gallus gallus,Homo sapiens)
• Signal transduction pathways used by superantigens and mediators (2012, NA)
• Impact of the cellular restriction factor APOBEC3 (A3) on human immunodeficiency virus-1 (HIV-1) replication (2012, NA)
• Functional roles of the arenavirus Z protein in the viral life cycle (2012, NA)
• PKR, ISG15 as modulators of IFN induction during HCV infection (2012, Mus musculus,NA,Homo sapiens)
• HCV and induction of the innate immune response (2012, Mus musculus,NA,Homo sapiens)
• PKR and the Insulin signaling pathway (2012, Mus musculus,NA,Homo sapiens)
• Treg regulatory pathways (2012, Homo sapiens,Macaca mulatta,Chlorocebus aethiops,Human immunodeficiency virus 1,Human immunodeficiency virus,Mus musculus,Candida albicans,Simian-Human immunodeficiency virus)
• Flavonoids biosynthetic pathway in maize (2012, NA)
• The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels (2012, NA)
• Apoptosis affects cell signaling pathways that control lipid synthesis and energy metabolism (2012, NA)
• MYC proteins and the p53/MDM2/p14ARFpathway (2012, NA)
• Von Hippel–Lindau/hypoxia-inducible factor oxygen-sensing pathway and its relevance in clear-cell renal cell carcinoma.Note: Copyright © 2010, Elsevier (2012, NA)
• Genomics in cardiovascular diseases: analysis of the importance of the toll-like receptor signaling pathway (2012, NA)
• Downstream molecular signals of the insulin receptor pathway (2012, Mus musculus,Homo sapiens)
• Proposed signaling pathway of effects of sEHI on MCP-1 and TNFA release in LPS-stimulated monocytes (2012, Homo sapiens,Mus musculus,Sus scrofa)
• Scheme for the TRPC signaling pathway in hypertrophy (2012, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Morchella esculenta,Ziziphus mauritiana,Homo sapiens)
• Transcriptome of genes encoding enzymes and proteins on the lactose synthesis pathway, including GLUT1, HK1, PGM1, UGP2, GALE, GALT, SLC35A2, LALBA, and B4-GALT1, -3, and -5 (2012, Homo sapiens)
• Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans (2012, Homo sapiens)
• Metabolites and their metabolic pathway networks measured by the Arg/Thiol Redox Metabolomics Assay (2012, NA)
• An expanded role of the tumor suppressor TSC1 in T cell tolerance (2012, NA)
• mTOR signaling pathway extracted from KEGG database (2012, Listeria monocytogenes,Streptomyces hygroscopicus,Cutibacterium acnes,Streptomyces tsukubensis,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Nitric oxide signaling pathway extracted from BioCarta database (2012, Listeria monocytogenes,Streptomyces hygroscopicus,Cutibacterium acnes,Streptomyces tsukubensis,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Fc epsilon receptor I signaling in mast cell pathway extracted from BioCarta database (2012, Listeria monocytogenes,Streptomyces hygroscopicus,Cutibacterium acnes,Streptomyces tsukubensis,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• T cell receptor signaling pathway extracted from BioCarta database (2012, Listeria monocytogenes,Streptomyces hygroscopicus,Cutibacterium acnes,Streptomyces tsukubensis,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Schematic diagram showing the RAS-MAPK signal transduction pathway (2012, NA)
• Hypothetic regulation of gene expression by HNF-4A by spherical cell shape in FLC-4 cells (2012, NA)
• Flow chart depicting the metabolic pathway of fatty acids in the liver of GH transgenic Amago based on 3′-tag digital gene expression profiling and comparison of serum triacylglycerol and glucose, and 3-hydroxybutyric acid (2012, NA)
• Pathway analysis derived by comparison of the relative abundance of metabolites from sera derived from patients with locoregional CRC and liver-only metastases, as determined by GC-MS (2012, NA)
• Signaling pathways impinging on autophagy (2012, Homo sapiens,Rattus norvegicus)
• Early Second Trimester Maternal Plasma Choline and Betaine Are Related to Measures of Early Cognitive Development in Term Infants (2012, NA)
• Transcriptional Programs Controlling Perinatal Lung Maturation (2012, NA)
• Functional analysis of the top-scoring network of AE9a dysregulated genes (2012, Homo sapiens,Mus musculus)
• Schematic model for TLRs activation by diverse mycobacterial antigens (2012, NA)
• Proposed mechanism for the spatiotemporal regulation of Rabex-5 in the endocytic trafficking of ubiquitinated L1 (2012, Homo sapiens)
• Speculative model of macrophage alternative activation regulation by estrogen (2012, NA)
• Cytokine-induced CITED2/MYC/E2F3/p21CIP1signaling in lung cancer (2012, NA)
• Isolation and characterization of GtMYBP3 and GtMYBP4, orthologues of R2R3-MYB transcription factors that regulate early flavonoid biosynthesis, in gentian flowers (2012, Arabidopsis thaliana,Nicotiana tabacum,Zea mays,Solanum lycopersicum,Embryophyta,Malus domestica,Sorghum bicolor,Fragaria x ananassa,Petunia x hybrida,Antirrhinum majus,Gerbera hybrid cultivar,Gentiana triflora,Agrobacterium tumefaciens,Helicoverpa zea)
• MTOR pathway (2012, NA)
• Tyrosine kinase receptors pathway (2012, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Schizosaccharomyces pombe,Vitis vinifera,Theobroma cacao,Hamamelis virginiana,Mus musculus,Rattus norvegicus,Triportheus paranensis,Glyptocephalus cynoglossus,Homo sapiens,Drosophila melanogaster,Paraechinus aethiopicus,Avian erythroblastosis virus)
• Canonical Wnt-Beta-catenin pathway (2012, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Schizosaccharomyces pombe,Vitis vinifera,Theobroma cacao,Hamamelis virginiana,Mus musculus,Rattus norvegicus,Triportheus paranensis,Glyptocephalus cynoglossus,Homo sapiens,Drosophila melanogaster,Paraechinus aethiopicus,Avian erythroblastosis virus)
• Methotrexate (MTX) mechanisms of action in the folate metabolic pathway (2012, NA)
• Proposed models of Ang II-induced apoptosis signaling in PAEC (2012, Homo sapiens,Bos taurus)
• Network and pathway structure for biologically informative priors in the cancer drug response data study (2012, Homo sapiens)
• Protein network and pathway structure for biologically informative priors in the synthetic response data study (2012, Homo sapiens)
• The interplay between pituitary hormones and main signaling pathways of the IGF system in thyroid, adrenal and ovary cancers (2012, NA)
• Characterized pathway for activation of STAT (2012, NA)
• PI3K/Akt/mTOR pathway regulates central carbon metabolism (2012, NA)
• Reactive oxygen species-mediated autophagy regulation (2012, NA)
• Mechanisms by which HER3 contributes to resistance to EGFR-targeted therapy (2012, NA)
• General features of the HER family (2012, NA)
• Ischemia-reperfusion stimulates multiple catabolic/autophagic cell signaling pathways during total knee arthroplasty (TKA) (2012, NA)
• Biological association network (BAN) of differentially expressed genes in common between CA and ICC (2012, NA)
• Major steps in MP3 and H-cell development (2012, Drosophila melanogaster,Homo sapiens)
• Activation of stress signalling pathways in the liver of sows during lactation (2012, NA)
• Octadecaneuropeptide ODN Protects Astrocytes against Hydrogen Peroxide-Induced Apoptosis via a PKA/MAPK-Dependent Mechanism (2012, NA)
• Role of Esrrb in ESC self-renewal and reprogramming (2012, Mus musculus,Homo sapiens)
• Working model depicting some of the multiple signaling pathways that have been reported to modulate cell-cycle activation and/or proliferation in rodent Beta-cells (2012, NA)
• Pathways regulating NEKs in cell cycle control (2012, Homo sapiens,Aspergillus nidulans)
• Intracellular vascular endothelial growth factor (VEGF) signal transduction pathway (2012, Homo sapiens)
• ERK1/2 phosphorylation of ICs regulating cytoplasmic dynein binding to endosomes in response to neurotrophin (2012, NA)
• Genes known to cause kidney cancer and their relationship with the mammalian target of rapamycin signaling pathway (2012, NA)
• The inter-relationship between hepcidinand HJVexpression during the inflammatory response, and the effect on iron flux (2012, Escherichia coli,Escherichia coli DH5alpha,Homo sapiens,Mus musculus,Bos taurus)
• Flow chart of the RANKL signalling pathway, illustrating the dependence of osteoclasts on osteoblasts for their function, and the role of MCP-1, MIP-1A and IL-6 (2012, NA)
• Main therapeutic targets along the BCR signaling pathway in CLL cells (2012, Homo sapiens,Mus musculus,Helicobacter pylori,NA)
• Role of stathmin in thrombin-induced endothelial barrier dysfunction and acute lung injury (2012, Homo sapiens,Mus musculus)
• CO prevents inflammatory responses via inhibition of NFKB signaling pathway (2012, Mus musculus,Rattus norvegicus,Olea europaea,Vasconcellea candicans,Homo sapiens)
• Regulation of the polyamines putrescine, spermidine and spermine by biosynthetic enzymes (shown in green) and catabolic enzymes (shown in red) (2012, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Type I IFN signaling pathway and inhibition by influenza A viruses (Figure adapted from ) (2012, NA)
• RIG-I signaling pathway and inhibition by influenza A viruses (Figure adapted from ) (2012, NA)
• Cell-signaling pathways from the UPR to autophagy and ER stress-induced apoptosis (2012, Curcuma longa,Allium sativum,Brassica rapa subsp. rapa,Nasturtium officinale,Mus musculus,Cricetulus griseus,Homo sapiens,Human immunodeficiency virus 1)
• Aberrations of PI3K-Akt-mTORC1 signaling pathway in prostate cancer (2012, Homo sapiens,Bos taurus)
• Synopsis of major pathways activating mTORC1 (2012, Homo sapiens,Bos taurus)
• Alterations in the NRF2 canonical pathway in livers of mice treated with TMHF (2012, Mus musculus,Homo sapiens)
• Signalling pathway with encoded therapeutic value information (2012, NA)
• Signalling schematic of the integrated pathway, with EGF and TGFB as the two external stimuli (2012, NA)
• Schematic illustrations of the two significant pathways in the genome-wide gene self-reported asbestos exposure interaction analysis (2012, Homo sapiens,Mus musculus,Nicotiana tabacum,Coronaviridae)
• Bone anabolism regulated by statins (2012, NA)
• TLR signaling overview: the TLR family can be subdivided into two categories (2012, Escherichia coli,Mycobacterium tuberculosis,Helicobacter pylori,Mycobacterium tuberculosis variant bovis,Borreliella burgdorferi,Treponema pallidum,Human immunodeficiency virus 1,Human papillomavirus type 16,Vaccinia virus,Homo sapiens,Macaca mulatta,Mus musculus)
• Impaired Skeletal Muscle Regeneration in the Absence of Fibrosis during Hibernation in 13-Lined Ground Squirrels (2012, NA)
• Expression Profile in Rice Panicle: Insights into Heat Response Mechanism at Reproductive Stage (2012, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Lareunionomyces loeiensis,Triticum aestivum,Hordeum vulgare,Pisum sativum,Vicia faba,Physcomitrium patens,Oryza sativa Japonica Group,Oryza sativa Indica Group,Trichoderma harzianum,Rosa chinensis,Vigna mungo,Oryza rufipogon,Oryza meridionalis,Escherichia coli,Synechococcus elongatus PCC 6301,Escherichia coli 14A,Mungbean yellow mosaic India virus,Homo sapiens)
• ERK1/2 and p38 MAPKs Are Complementarily Involved in Estradiol 17ß-d-Glucuronide-Induced Cholestasis: Crosstalk with cPKC and PI3K (2012, NA)
• Summary of how microenvironmental factors typically affect signaling pathways regulating alternative splicing and translation (2012, NA)
• The signaling pathway by which FSH promotes AKT activation in GCs (2012, NA)
• The signaling pathway by which FSH promotes AKT activation in GCs (2012, NA)
• Comparison of theoretical maximum yields of pentanol biosynthesis through various biosynthetic pathways (2012, NA)
• Metabolic pathway construction for direct microbial synthesis of pentanol from glucose or glycerol (2012, NA)
• Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP (2012, NA)
• Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP (2012, NA)
• Signaling partners involved in oxidative stress mediated Egr-1 signaling (2012, NA)
• Selected signaling pathways in renal cell carcinoma (RCC) (2012, NA)
• ErbB signaling and inhibition in tumour cell (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• HCV Infected Cellular Distribution of PIPs, Binding Proteins (2012, Enterovirus C,Enterovirus A71,Coxsackievirus,Polyomavirus sp.,Aichivirus A,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Autophagy process (2012, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Dengue virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Vaccinia virus,Enterovirus C,Japanese encephalitis virus,Sindbis virus,Murine hepatitis virus,Tobacco mosaic virus,Hepatitis C virus genotype 1,Avian orthoreovirus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,NA)
• Cellular intoxication by LT (2012, NA)
• Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling pathway in cell proliferation in solid cancer (2012, NA)
• Signal transduction in solid cancer cells including hepatocellular carcinoma (2012, NA)
• EGFR signaling cascade (2012, NA)
• Phactr4 function in regulating directional migration (2012, NA)
• Asparagine N-Glycosylation pathway (2012, NA)
• Flow chart showing the genes involved in TLR signaling pathway (2012, Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Measles morbillivirus,Human alphaherpesvirus 2,Ectromelia virus,Chandipura virus,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster)
• SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR (2012, NA)
• IPA network analyses were applied to differentially expressed genes in mouse brain after in vivo ketamine exposure (2012, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Agonist and antagonist roles for Ang2 on Tie2 function (2012, Mus musculus,Homo sapiens)
• Effect of Dicycloplatin, a Novel Platinum Chemotherapeutical Drug, on Inhibiting Cell Growth and Inducing Cell Apoptosis (2012, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Isaria japonica,Homo sapiens,Mus musculus)
• MUC5B gene expression is transcriptionally regulated by various mediators and pathways (2012, NA)
• Transcriptional regulation of the cytoprotective phase 2 genes under control of the transcriptional factor nuclear factor-E2 p45-related factor 2 (Nrf2) (2012, Rattus norvegicus,Homo sapiens)
• Analysis of Differential miRNA Expression in the Duodenum of Escherichia coli F18-Sensitive and -Resistant Weaned Piglets (2012, NA)
• Enantioselective Cytotoxicity Profile of o,p’-DDT in PC 12 Cells (2012, NA)
• Cancer-suppressive inflammation (2012, NA)
• Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells (2012, NA)
• Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes (2012, Homo sapiens)
• TGFB non-canonical signaling pathway (2012, Homo sapiens)
• Microbes-induced EMT at the crossroad of inflammation and cancer (2012, NA)
• Regulation of MDM2 by chronic stress and neurohormones (2012, NA)
• Downstream anti-inflammatory effects of AMPK signaling (2012, NA)
• Impact of SIRT1 knockout on selected cellular pathways and protein complexes (2012, NA)
• VANTED integrated pathway map of quantitative regulation of metabolites and enzymes of primary metabolism under nitrogen limitation in Chlamydomonas reinhardtii (2012, NA)
• Baculovirus infection impact on host cell metabolism (2012, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Measles morbillivirus,Betapolyomavirus macacae,Coxsackievirus B3,Polyomavirus sp.,African swine fever virus,Cowpox virus,Human respirovirus 3,Human betaherpesvirus 6A,Autographa californica nucleopolyhedrovirus,Bombyx mori nucleopolyhedrovirus,Autographa californica multiple nucleopolyhedrovirus,unidentified nuclear polyhedrosis viruses,Orgyia pseudotsugata multiple nucleopolyhedrovirus,Lymantria dispar multiple nucleopolyhedrovirus,Spodoptera littoralis nucleopolyhedrovirus,Cydia pomonella granulovirus,Spodoptera frugiperda multiple nucleopolyhedrovirus,Trichoplusia ni granulovirus,Helicoverpa zea single nucleopolyhedrovirus,Anticarsia gemmatalis multiple nucleopolyhedrovirus,Trichoplusia ni single nucleopolyhedrovirus,Helicoverpa armigera nucleopolyhedrovirus,Epiphyas postvittana nucleopolyhedrovirus,Rachiplusia ou MNPV,Drosophila melanogaster,Bombyx mori,Spodoptera frugiperda,Helicoverpa armigera,Trichoplusia ni,Helicoverpa zea,Heliothis virescens,Autographa californica,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,vectors,NA)
• Mechanisms by which AP-1 transcription factor regulates LY6K expression, which activates the ERK signaling pathway to mediate cell invasive motility and metastasis in human breast cancer cells (2012, NA)
• Suggested Ca2+-dependent signaling pathway from amino acid starvation to autophagy (2012, Homo sapiens,Mus musculus)
• TP53 mutation status-specific network of potential candidate driver genes shown based on their known and predicted functional interactions (2012, Homo sapiens,Mus musculus)
• Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease (2012, Mus musculus,Homo sapiens)
• Multi-omic map of the lipid-producing yeast Rhodosporidium toruloides (2012, Saccharomyces cerevisiae,Olea europaea,Schizosaccharomyces pombe,Cryptococcus neoformans,Yarrowia lipolytica,Rhodotorula toruloides,Mucor circinelloides,Metarhizium anisopliae,Rhodotorula glutinis,Rhodotorula graminis,Rhodotorula toruloides NP11,Aspergillus sp. ATCC 58397,Homo sapiens,Apis mellifera)
• Constitutive ß-Catenin Signaling by the Viral Chemokine Receptor US28 (2012, NA)
• Histidine kinases in plants (2012, NA)
• RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways (2012, NA)
• STRING Network (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• ERBB Pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Proposed NPY signalling pathway for the regulation of blood pressure (BP) and heart rate (HR) in the NTS (2012, NA)
• Ligand-specific signalling complexes at the µ opioid receptor (2012, NA)
• Synaptic model of caffeine-MDMA interactions (2012, NA)
• Distinct roles for AlphaB hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling (2012, NA)
• Diagrammatic representation of BMP signaling pathway (2012, NA)
• AID-associated gene network (2012, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,NA)
• Core PCP module in Drosophila (2012, Gallus gallus,Danio rerio,Xenopus laevis,Phoenicopterus roseus,Homo sapiens,Mus musculus,Drosophila melanogaster,Mustela lutreola)
• NOD1 and NOD2 signaling pathways and interaction partners (2012, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Salmonella enterica,Clostridioides difficile,Porphyromonas gingivalis,Bacillus anthracis,Shigella flexneri,Haemophilus influenzae,Campylobacter jejuni,Borreliella burgdorferi,Chlamydia trachomatis,Citrobacter rodentium,Legionella pneumophila,Brucella abortus,Chlamydia pneumoniae,Cutibacterium acnes,Clostridioides difficile CD3,Moraxella bovis,Burkholderia pseudomallei,Helicobacter hepaticus,Clostridioides difficile CD8,Chlamydia muridarum,unidentified influenza virus,Respiratory syncytial virus,Murine norovirus 1,Mus musculus,Rattus norvegicus,Trypanosoma cruzi,Plasmodium berghei ANKA,Homo sapiens)
• Principal IFN-Alpha-modulated canonical pathway in MT-4 cells (2012, NA)
• MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains (2012, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I,NA)
• MicroRNA targetome suggests aberrant upregulation of T cell receptor signaling pathway molecules in ATL cells (2012, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I,NA)
• MicroRNA targetome suggests aberrant upregulation of cell cycle regulators in AD brains (2012, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I,NA)
• Two Ca2+-mediated signaling pathways that have been shown to modulate muscle phenotype (2012, NA)
• Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells (2012, NA)
• 5-HT6 receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia (2012, NA)
• FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators (2012, NA)
• Simplified schematic representation of the mammalian target of rapamycin (mTOR) signaling pathway.Notes: Red, pathway inhibitor; Green, pathway activator; Blue, mTOR complex protein.Abbreviation: NOS, not otherwise specified (2012, NA)
• Diagrammatic presentation shows how Notch and TGFB signaling pathway involved at each pathogenic stage of HBV infection (2012, NA)
• Master Regulators in the Metabolic/Transcriptional Coupling in Breast Carcinomas (2012, Human papillomavirus,Human betaherpesvirus 5,Homo sapiens,Mus musculus,Arabidopsis thaliana,vectors,Corynebacterium phage gamma)
• The signaling pathway ofGHRregulated by let-7b (2012, Bos taurus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Diaporthe sclerotioides)
• PAK signaling in cancer (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Pathway enrichment map of first degree partners of targets of functional miRNAs predicted in Figure (2012, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Prostate cancer miRNA targets are enriched with pathways associated with cancer (2012, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Reactions involved in the flux of fatty acids into (2012, Arabidopsis thaliana)
• Recipient T-lymphocytes govern Mesenchymal stem cell (MSC)-based bone regeneration via IFNG and TNFA (2012, NA)
• Mechanism for postsynaptically expressed PACAP-induced synaptic enhancements in the BLA–CeL projections (2012, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli KD1,Homo sapiens)
• PI3K-Akt-mTORC1 pathway and control of autophagy (2012, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Signalling events activating PKB/Akt and cellular functions regulated by PKB/Akt (2012, NA)
• Simplified illustration of the canonical Wnt signaling pathway (2012, NA)
• Representative KEGG pathway change of Endocytosis (2012, NA)
• New insights on the role of CD8+CD57+ T-cells in cancer (2012, NA)
• TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis (2012, NA)
• Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy (2012, NA)
• Signaling networks induced in the spleen at 1 day post infection in wild-type mice (A) and STAT1 KO mice (B) (2012, Dengue virus,Rift Valley fever virus,Homo sapiens,Mus musculus,Sequoia sempervirens,NA,NA,NA,NA,NA)
• HDL promotes regression (2012, NA)
• Proposed model of HER2/3 signaling in epithelial cells (2012, NA)
• TRPC5-mediated feedback of Ca2+ and NO signaling in endothelial cells and attenuation of Ca2+ entry through TRPC6 by NO in smooth muscle cells (2012, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Escherichia coli)
• Significant sub-networks (see also ) found among the lists of most essential genes, ranked by the RIGER parameter, obtained for both cell lines: (A) Jurkat and (B) K562 (2012, NA)
• Schematic pathway of MLT's action on GSK3B and EMT (2012, Homo sapiens,Rattus norvegicus)
• Expression of suicide genes in T lymphocytes (2012, NA)
• Emerging role of autophagy in kidney function, diseases and aging (2012, NA)
• Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition (2012, NA)
• DKK1 as a novel target for myeloma immunotherapy (2012, NA)
• Mathematical Model of CR3/TLR2 Crosstalk in the Context of Francisella tularensis Infection (2012, NA)
• Mathematical Model of CR3/TLR2 Crosstalk in the Context of Francisella tularensis Infection (2012, NA)
• Network analysis of the host factors found to be associated with the extremities of the murine norovirus genome (2012, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Murine norovirus)
• AMPK/ERK/TSC2/mTOR signaling in PCV2-induced autophagy in PK-15 cells (2012, NA)
• A2A-receptor actions in SH-SY5Y cells (2012, NA)
• The regulation of mutacin production in S (2012, NA)
• Glutamine:fructose-6-phosphate amidotransferase 1 (GFPT1)–mediated MTOR signaling pathway affected by glucose and fructose in porcine trophectoderm cells (2012, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Komagataella pastoris,synthetic gene)
• Opposing roles of FGF2 and BMP4 in directing TB formation from epiblast type ES cells and iPS cells and the need to exclude FGF2 from the growth medium to minimize the co-induction of mesoderm and endoderm (2012, NA)
• Schematic depicting a central role for transforming growth factor (TGF)B1 signaling in osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis (LCH) (2012, Homo sapiens)
• Summary of pathways controlling muscle protein synthesis (MPS) and muscle protein breakdown (MPB) (2012, NA)
• Molecular relational network of genes modulated by BaP in lung tissues enriched for cancer function using IPA for all three doses with p53 at the central node (2012, NA)
• Astrocytes as memory elements (2012, NA)
• TRAIL signaling pathway and mechanisms of TRAIL resistance (2012, Oryza sativa,Triticum aestivum,Hordeum vulgare,herbal medicine,Zingiber officinale,Scutellaria baicalensis,Citrus x paradisi,Trigonella foenum-graecum,Azadirachta indica,Garcinia indica,Homo sapiens,Caenorhabditis elegans)
• Rbf1 occupies multiple nodes in conserved signaling pathways (2012, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Arabidopsis thaliana,Middle East respiratory syndrome-related coronavirus)
• The PI3K/Akt/mTOR pathway: Ligands binds to the receptor tyrosine kinases like EGFR, IGF1R, Her2, and Ras leads to conformational changes and activates PI3K (2012, NA)
• Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway (2012, Homo sapiens)
• Insulin like growth factor (IGF) and insulin receptor (IR) signaling system (2012, NA)
• Downstream signaling of the IGF-1R (2012, NA)
• G protein-dependent signaling pathways activated by VPAC receptors (2012, NA)
• Alterations induced in the CD8+ T-cells by lung cancer (2012, NA)
• Novel Genes and Pathways Modulated by Syndecan-1: Implications for the Proliferation and Cell-Cycle Regulation of Malignant Mesothelioma Cells (2012, Homo sapiens,Mus musculus,Armoracia rusticana,Hepatitis B virus)
• Postulated mechanism of FWFE on modulating insulin signaling and inflammation pathway in TNF-Alpha-induced insulin resistant FL83B cells (2012, NA)
• Regulatory function of TIR8/SIGIRR in signaling (2012, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Listeria monocytogenes,Mycobacterium tuberculosis SP1,Lactobacillus jensenii,Gallus gallus,Candida albicans,Aspergillus fumigatus,teleost fish,Homo sapiens,Mus musculus)
• Canonical biogenesis pathway and mechanisms of miRNA deregulation (2012, NA)
• CD73-generated adenosine orchestrates the tumor-stroma interplay to promote cancer growth (2012, Homo sapiens,Mus musculus)
• VEGF pathway and its targets for inhibition (2012, Homo sapiens)
• CB1 cannabinoid receptor signalling and regulation of neural stem/progenitor cell proliferation (2012, NA)
• Pathway Diagram of Oxidative Stress along with PI3k/Akt (2012, Homo sapiens,Aphyosemion alpha)
• Schematic summary of the results obtained from the microarray analysis (2012, Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus caballus,Equus asinus,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Overlapping network between MCF-7 and ZR-75.1 cells (2012, Homo sapiens,Escherichia coli,Tragelaphus oryx)
• ERA genomic network (2012, Homo sapiens,Escherichia coli,Tragelaphus oryx)
• PRb/E2F signaling pathway mediates three distinct arms of TGFB tumor-suppressive effects (2012, Bos taurus,Armoracia rusticana,Capra hircus,Silene chalcedonica,Homo sapiens,Mus musculus,vectors)
• The different main molecular pathways that are involved in neuronal stress response (2012, NA)
• Scheme demonstrating mechanisms used by natural compounds to drive changes in the epigenome (2012, NA)
• Innate immune signals during B (2012, NA)
• PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent (2012, NA)
• Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line (2012, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Regulation of Epidermal Growth Factor Receptor Signaling and Erlotinib Sensitivity in Head and Neck Cancer Cells by miR-7 (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• A Systems Biology View of Responses to Lignin Biosynthesis Perturbations in Arabidopsis (2012, Arabidopsis thaliana)
• Metabolic Map of Phenolic Metabolism in the Inflorescence Stem of Arabidopsis.The main pathways involved in lignin biosynthesis are framed with a bold black border (2012, Arabidopsis thaliana)
• Ras/PKA and Gpa2 pathways (2012, NA)
• TORC1 and nitrogen regulation (2012, NA)
• Signaling pathways regulating lipogenesis in cancer cells (2012, NA)
• NFKB members and NFKB signaling (2012, NA)
• Regulating IRES-mediated LamB1 translation during hepatocellular EMT and carcinoma progression (2012, NA)
• Multilevel factors cooperatively perturb pathways (2012, NA)
• PPI subnetworks of the extended disease pathways (2012, Escherichia coli,Helicobacter pylori,Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Canis lupus familiaris,prion,Human betaherpesvirus 6,NA)
• Signaling pathways regulated by ROS in C (2012, NA)
• Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels (2012, Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Positive and negative regulations in the Ras/cAMP/PKA pathway (2012, NA)
• Signaling pathway for CREB in the regulation of FMRP by Group I mGluRs in ACC neurons (2012, NA)
• Mitochondrial fission and autophagy events are activated after 6-OHDA addition (2012, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Schematic model illustrating the oncogenic pathway addiction (2012, NA)
• Model depicts the development of conventional vs (2012, NA)
• Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K (2012, NA)
• signaling pathways triggered by L1CAM (2012, Homo sapiens)
• Effect of HDL/apoA-I on autophagy in preadipocyte (2012, NA)
• Class I PI3K signal transduction pathway (2012, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Neurofibromin signaling pathway regulation (2012, Homo sapiens,Mus musculus)
• Mechanisms of acquired-resistance to vemurafenib (2012, Homo sapiens)
• TLR signaling and proposed model for DMF-mediated impairment of DC maturation (2012, NA)
• Interaction between the insulin/Igf-like (IIS) signaling pathway with immune function and pathogen resistance in Drosophila (2012, NA)
• Raf signalling pathway (2012, NA)
• Specific and non-specific mechanisms of oligodendrocyte injury (2012, Homo sapiens,Mus musculus,Nicotiana tabacum,vectors)
• Signaling mechanisms of oligodendrocyte injury (2012, Homo sapiens,Mus musculus,Nicotiana tabacum,vectors)
• Blood–brain barrier (BBB) transport in homeostasis of brain AB (2012, NA)
• Conceptual schematic of M (2012, NA)
• Biosynthesis of glycerophospholipids (2012, NA)
• Major signaling pathways of IPC- and Ipost-mediated protection against cardiac cell death (2012, NA)
• Establishment of Mouse Teratocarcinomas Stem Cells Line and Screening Genes Responsible for Malignancy (2012, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus)
• Scheme of the various interactions between GSTs and MAPK implicated in stress-signaling pathway (adapted from ) (2012, NA)
• Thiol-redox signaling and apoptotic signaling cascades (2012, NA)
• Signaling pathways mediated by rat sarcoma (Ras) and protein kinase B (Akt) (2012, NA)
• Apoptotic signaling through tumor necrosis factor superfamily receptor 6 (Fas) and tumor necrosis factor receptor (TNFR) (2012, NA)
• Mitochondrial energy–redox axis and generation of redox- and energy messengers (2012, NA)
• Diagram demonstrating the sites and mechanism of action of novel agents for the management of pancreatic endocrine neoplasm (2012, Dipturus trachyderma,Homo sapiens)
• Schematic presentation of molecular changes associated with N-Myc amplification in neuroblastoma (2012, Human alphaherpesvirus 1,Adeno-associated virus,Homo sapiens,Mus musculus)
• Genomic and non-genomic actions of all-trans retinoic acid (ATRA) (2012, Human alphaherpesvirus 1,Adeno-associated virus,Homo sapiens,Mus musculus)
• EA improves ERK signaling pathways through the regulation of neuroendocrine cytokines in myocardial hypertrophic rats (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Molecular basics of tumor angiogenesis (2012, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Semliki Forest virus,NA)
• IL-10 signal transduction and hypothesized treatment by dual gene therapy (2012, NA)
• Cellular signaling pathways that control normal hematopoiesis and apoptosis (2012, NA)
• Abrin (ABR)-triggered apoptosis (2012, NA)
• Proposed model of functions of N-glycosylation in A (2012, NA)
• Pathways and functions of protein glycosylation in A (2012, NA)
• Function of integrin linked-kinase (ILK) in normal and activated stellate cells–implications for fibrogenesis in wound healing (2012, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Orai1, STIM1, and their associating partners (2012, NA)
• Pathway Tools output of gene expression data of L664 relative to SL1344 (2012, Salmonella enterica subsp. enterica serovar Typhimurium)
• Theoretical structure of this triple-hit nALI model as a translational study (2012, NA)
• Proteomic Analysis of Lysine Acetylation Sites in Rat Tissues Reveals Organ Specificity and Subcellular Patterns (2012, NA)
• Tumour necrosis factor receptor trafficking dysfunction opens the TRAPS door to pro-inflammatory cytokine secretion (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Human adenovirus 14)
• Interplay between autophagy and intracellular pathogens (2012, NA)
• Post-translational modifications (PTMs) of transcription factors (2012, NA)
• Proposed model of IFNT signal transduction cascades that is independent of STAT1 in the ovine uterine LE and sGE (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Camelus bactrianus,Vicugna pacos,Camelus dromedarius,Bubalus bubalis,Lama glama,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Schematic illustration of the current working hypothesis on IFNT signaling in ovine uterine stroma and uterine glandular epithelium compared to uterine luminal (LE) and supferficial glandular (sGE) epithelia (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Ovis aries,Equus caballus,Camelus bactrianus,Vicugna pacos,Camelus dromedarius,Bubalus bubalis,Lama glama,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Primary phosphatases function as tumor suppressors and their signaling pathways (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Xenopus laevis,Betapolyomavirus macacae)
• Schematic diagram depicting the possible pathways in which NO modulates collagen type I gene expression to affect fibrosis (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Camellia sinensis)
• Schematic summary of the proposed role of mitochondrial cardiolipin oxidation in Beta-cell failure in type 2 diabetes mellitus (2012, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Drosophila melanogaster)
• Downregulation of macrophages signalling by Leishmania infection (2012, Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Trypanosoma brucei,Leishmania major,Leishmania donovani,Leishmania mexicana,Leishmania amazonensis,Leishmania chagasi,Acanthocheilonema viteae,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus,Candida dubliniensis)
• Subnetwork using the layered layout (2012, Escherichia coli,Bacillus subtilis,Escherichia coli K-12,Escherichia coli IS1,Escherichia coli str. K-12 substr. MG1655,Bacillus subtilis subsp. subtilis,Shewanella oneidensis,Shewanella oneidensis MR-1,Shewanella sp.,Mus musculus,Octodon degus,Homo sapiens,Saccharomyces cerevisiae,Venustaconcha ellipsiformis)
• Exercise activates a wide variety of intracellular signal transduction pathways to promote neurogenesis of granule cells from neuroprogenitors in the dentate gyrus (2012, NA)
• Role of MALT1 in signaling to NFKB in ABC DLBCL (2012, NA)
• Ingenuity pathway analysis (IPA) displaying regulatory relationships among highly expressed (green) and lower (red) placental transcripts in less muscular women as compared with women with high arm muscle area (2012, Homo sapiens)
• Recent focus in JMML has concentrated on using the information gained from knowledge of these molecular defects in order to design targeted drug therapy (2012, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Metabolic pathways regulating oxidative stress and endosome traffic controlling the recycling of receptor and adaptor proteins between the cell surface and lysosomes (2012, Homo sapiens)
• Ancestral Ca2+ Signaling Machinery in Early Animal and Fungal Evolution (2012, Opisthokonta,Homo sapiens)
• AR-independent promotion of prostate cancer (PCa) cell proliferation and angiogenesis by the SUMO pathway (2012, NA)
• Simplified schema of interconnections between small ubiquitin-related modifier (SUMO) pathway proteins and other factors regulating androgen receptor (AR)-dependent transcription (2012, NA)
• Adaptation of endothelial cells to inflammatory stimuli and hypoxia (2012, Homo sapiens,Papio hamadryas,Papio ursinus,Mus musculus,Rattus norvegicus,Bos taurus,NA)
• Fungal cell wall pathogen-associated molecular patterns (PAMPs) and their host-pattern recognition receptors (PRRs) (2012, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Ambrosia artemisiifolia,Amylomyces rouxii,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Nippostrongylus brasiliensis,Dermatophagoides pteronyssinus,Wuchereria bancrofti,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens)
• Hypothetical model for a molecular chitinase response to chitin-containing pathogens or particles (2012, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Ambrosia artemisiifolia,Amylomyces rouxii,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Nippostrongylus brasiliensis,Dermatophagoides pteronyssinus,Wuchereria bancrofti,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens)
• Effect of FXR activation on triglyceride and cholesterol metabolism in the liver (2012, NA)
• Resistance mechanisms in the TRAIL signaling pathway (2012, NA)
• Non-apoptotic TRAIL signaling (2012, Homo sapiens)
• Ovarian cancer ascites-mediated protection from TRAIL-induced apoptosis (2012, Homo sapiens)
• Proposed signaling pathway regulating GLUT12 translocation and glucose transport (2012, NA)
• Regulation of intracellular signaling by antiepileptics and modulators of glutamate, acetylcholine, and melatonin systems (2012, NA)
• Gene expression changes in cell cycle pathways (2012, Homo sapiens)
• Summary of statin‐mediated peroxisome proliferator‐activated receptor G (PPARG) activation in macrophages (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Candida dubliniensis)
• Activation of DCs by HKBA showing the stimulation of TLR2 and TLR9 and cross-talk between their respective signal transduction pathways (2012, NA)
• Proposed MAPK pathways and their inhibitors involved in EVT dysfunction during an inflammatory state (2012, NA)
• Putative pathway of the inhibition of LPS-activated inflammatory signaling by compound 7 (2012, NA)
• TOB1 was involved in regulation of tumor growth and metastasis via the PI3K/PTEN signaling pathway (2012, NA)
• Molecular control of palatal shelf growth and patterning (2012, NA)
• Fatty acid Beta-oxidation, TG synthesis, and phospholipid biosynthesis pathways (2012, Homo sapiens)
• Metabolic pathways illustrating TCDD-elicited changes in the mouse (A) and rat (B) (2012, Mus musculus,Rattus norvegicus,Candida dubliniensis,Homo sapiens)
• Epithelial–mesenchymal transition (EMT)-related pathways (2012, Homo sapiens)
• Peli1 mediates IKK activation by the TRIF-dependent TLR pathway (2012, NA)
• Current model for NFKB signaling pathway induced by C-type lectin receptors (2012, NA)
• Disease/drug mapping is the process to map all known disease genes (pink) and all known drug targets (light blue) against all KEGG pathway maps (2012, metagenomes,environmental samples,Homo sapiens,Escherichia coli,Phascolarctos cinereus)
• Reformatted modeling of the BioCarta ‘apoptotic signaling in response to DNA damage’ pathway (2012, Homo sapiens)
• Non-canonical Wnt-signaling pathway (2012, NA)
• PI3K-AKT pathway and associated cellular activities (2012, Homo sapiens)
• Gab2 interactions with binding partners (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Pan troglodytes,Friend spleen focus-forming virus)
• PP-associated modulation of inflammatory chemokine production and repair-related processes in keratinocytes through EGFR system (2012, NA)
• Representation of the resistance mechanisms to the vemurafenib (2012, Homo sapiens,Mus musculus,NA)
• Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice (2012, NA)
• Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer (2012, NA)
• Schematic working model for DR5 up-regulation induced by the oncogenic Ras or B-Raf (2012, NA)
• Signal integration among regulatory proteins and pathways that control filamentous growth (2012, NA)
• Simplified diagram depicting the proposed signaling pathway of the CB1 activation that inhibits the activity of small GTPase RhoA to inhibit motility of PC-3 cells (2012, NA)
• Disruptions in STEP associated with excitotoxicity, Alzheimer's disease, and drugs of abuse (2012, NA)
• CR-associated signaling and some of its key players (2012, Homo sapiens)
• Visualization of the quantity of genes differentially regulated by Gamma-tocotrienol (GT3) and Alpha-tocopherol (aTOC) using the KEGG cell cycle pathway (2012, NA)
• TGFB signal transduction pathway and targets for therapeutic intervention (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus,NA)
• Mechanisms and consequences of TGF-ß overexpression by podocytes in progressive podocyte disease (2012, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Canis lupus familiaris,Euonymus japonicus)
• Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells (2012, Mus musculus,Rattus norvegicus,Salvia miltiorrhiza,Panicum miliaceum,Homo sapiens,Hepatitis B virus,NA)
• Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes (2012, NA)
• Class IA PI3Kinase Regulatory Subunit, p85A, Mediates Mast Cell Development through Regulation of Growth and Survival Related Genes (2012, NA)
• Proposed similarities and differences in the maps of E (2012, NA)
• TGFB response pathway (2012, Homo sapiens,Mus musculus,Bos taurus,vectors,NA)
• Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner (2012, NA)
• Fas-induced apoptotic signalling pathway (2012, NA)
• Sensitisation of type 2 cancer cells towards DR-induced killing by synthetic IAP antagonists (2012, NA)
• The generation of CaR-induced Ca2+i oscillations based on dynamic phosphorylation of CaRT888 (2012, Mus musculus,Homo sapiens)
• Summary of the results presented in this study (2012, NA)
• Identification of Gene Networks and Pathways Associated with Guillain-Barré Syndrome (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Plasmodium falciparum,Campylobacter jejuni)
• MiRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols (2012, NA)
• Curbing autophagy and histone deacetylases to kill cancer cells (2012, NA)
• Factors affecting the viability of dopamine neurons (2012, NA)
• Oncogenic and tumor suppressor control of metabolism (2012, NA)
• Fine adjustment of autophagy by the AMPK-mTORC1-Ulk1/2 kinase network (2012, NA)
• TLR4 signaling pathway (2012, Influenza A virus,Orthomyxoviridae,H5N1 subtype,Mus musculus,Homo sapiens)
• Modeling of miRNA and Drug Action in the EGFR Signaling Pathway (2012, NA)
• Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells (2012, Homo sapiens,Mus musculus,Bos taurus,Human gammaherpesvirus 8)
• Alpha-Tocopherol Alters Transcription Activities that Modulates Tumor Necrosis Factor Alpha (TNFA) Induced Inflammatory Response in Bovine Cells (2012, Homo sapiens,Mus musculus,Bos taurus,Human gammaherpesvirus 8)
• TWEAK-Fn14 signaling system (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Products for which C (2012, Corynebacterium glutamicum,Homo sapiens)
• KEGG Pathway database map showing Notch signaling including proteolytic cleavage and translocation of Notch followed by transcriptional activation of Notch target genes (2012, NA)
• Overall regulation mechanism for the main metabolism by enzyme level regulation and transcriptional regulation (2012, NA)
• Main metabolic pathways of E.coli together with transcription factors (2012, NA)
• Signal transduction by TGFB family members (2012, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens)
• PI3K pathway activated by EGF-stimulated EGFR or by the constitutively activated EGFRvIII (2012, NA)
• Role of the Phactr4–PP1 complex in normal ENCCs (2012, NA)
• Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer (2012, Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus)
• Integrin signalling pathway (2012, NA)
• The regulatory function of UBD-GEF proteins auto-ubiquitylation (2012, Saccharomyces cerevisiae,Escherichia coli,Danio rerio,Homo sapiens)
• Schematic model depicting the different overlapping phases of KSHV entry and infection in endothelial (HMVEC-d) target cell (2012, Human gammaherpesvirus 4,Human immunodeficiency virus,Human gammaherpesvirus 8,Vaccinia virus,Human adenovirus 5,Murid gammaherpesvirus 4,Saimiriine gammaherpesvirus 2,Macaca mulatta rhadinovirus,Escherichia coli,Clostridioides difficile,Clostridioides difficile CD34,Clostridioides difficile CD49,Homo sapiens,Mus musculus,Cricetus cricetus,Aotus trivirgatus,NA)
• Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma (2012, NA)
• Schematic depiction of crosstalk between Notch and HIF-1A (2012, Rattus norvegicus,Homo sapiens)
• Metals on the PLC signaling pathway at presynaptic terminal (green: activation/increase, red: inhibition/decrease) (2012, NA)
• Metals on the PLC signaling pathway at presynaptic terminal (green: activation/increase, red: inhibition/decrease) (2012, NA)
• Cyclooxygenase-dependent arachidonic acid pathway in platelets (2012, Canis lupus familiaris,Ovis aries,Rattus norvegicus,Actinobacillus minor,Homo sapiens)
• Hypothetical model showing intracellular events in conferring amphotericin B resistance (2012, Leishmania donovani)
• Proposed model for regulation of HCV replication mediated by the Ras/Raf/MEK pathway (2012, NA)
• Metabolism in cones (2012, Homo sapiens,Mus musculus,Danio rerio,Sus scrofa,Arachis hypogaea,Adeno-associated virus)
• PGC-1Alpha- and AMPK-mediated regulation of IL1Rn expression in hepatocytes (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Progesterone Inhibits Epithelial-to-Mesenchymal Transition in Endometrial Cancer (2012, NA)
• CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression (2012, NA)
• Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma (2012, Homo sapiens)
• Basal cell carcinoma — molecular biology and potential new therapies (2012, Homo sapiens,Mus musculus,Dipturus trachyderma)
• HCMV Targets the Metabolic Stress Response through Activation of AMPK Whose Activity Is Important for Viral Replication (2012, Hepatitis B virus,unidentified influenza virus,Human betaherpesvirus 5,Vaccinia virus,Enterovirus C,Human adenovirus 5,Feline leukemia virus,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Gallus gallus,Bacteriophage sp.,NA)
• PI3K/Akt pathway (2012, Homo sapiens)
• Deeply Branching Thermophilic Bacterium with an Ancient Acetyl-CoA Pathway Dominates a Subsurface Ecosystem (2012, Bacillus subtilis,Thermus thermophilus,Deinococcus radiodurans,Moorella thermoacetica,Acetobacterium woodii,Enterococcus hirae,Geobacillus kaustophilus,Halalkalibacterium halodurans,Carboxydothermus hydrogenoformans,Hydrogenobacter thermophilus,Deinococcus radiodurans R1 ATCC 13939 DSM 20539,Bacteria incertae sedis,Hydrogenophilus thermoluteolus,Candidatus Caldarchaeum subterraneum,Bacillus subtilis QH-1,Candidatus Acetothermum autotrophicum,Methylohalobius crimeensis,Herbaspirillum autotrophicum,Geobacillus kaustophilus HTA426,Carboxydothermus hydrogenoformans Z-2901,Thermus arciformis,uncultured bacterium,uncultured bacterium Of10,uncultured bacterium Contig2,uncultured bacterium Contig4)
• Inhibition of Wnt/Beta-Catenin Signaling by a Soluble Collagen-Derived Frizzled Domain Interacting with Wnt3a and the Receptors Frizzled 1 and 8 (2012, NA)
• Coxiella burnetii Induces Apoptosis during Early Stage Infection via a Caspase-Independent Pathway in Human Monocytic THP-1 Cells (2012, Coxiella burnetii,Homo sapiens)
• Metabolic pathway of AA transformation into eicosanoid products (2012, Human immunodeficiency virus 1,Human immunodeficiency virus,Vesicular stomatitis virus,Simian immunodeficiency virus,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,unidentified,Klebsiella pneumoniae)
• Representation of signalling transduction via adiponectin receptor activation (2012, Mus musculus,Homo sapiens)
• Tumour suppressor p53 regulation and signalling (2012, Homo sapiens,Adenoviridae)
• Pathways and compartmentation of FA supply for TAG synthesis in plants (2012, Homo sapiens)
• Acyl-CoA-dependent and acyl-CoA-independent pathways for TAG biosynthesis in plants (2012, Homo sapiens)
• Integrins Regulate Microtubule Nucleating Activity of Centrosome through Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase/Extracellular Signal-regulated Kinase (MEK/ERK) Signaling (2012, NA)
• Schematic diagram showing the mechanism by which uPA/uPAR shRNA inhibits angiogenesis in glioblastoma cells and xenografts (2012, Homo sapiens,Mus musculus,Adeno-associated virus)
• Pathways involved in aging (2012, NA)
• Interaction of TOR pathway members for the regulation of phagocytosis (2012, Saccharomyces cerevisiae,Homo sapiens)
• Metabolism of retinoids (A) and isoprenoids (B) (2012, NA)
• DN Tregs employ multiple mechanisms to exert antigen-specific control over immune responses (2012, NA)
• TGFB signaling and negative regulation in bone formation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Aggregatibacter actinomycetemcomitans)
• BMP signaling and negative regulation in bone formation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Aggregatibacter actinomycetemcomitans)
• Regulation of proliferation and survival pathways by protein kinases activation in response to UV radiation (2012, NA)
• Signaling pathways leading to transcription factors activation in response to UV-radiation (2012, NA)
• Regrowing the Adult Brain: NFKB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus (2012, Mus musculus,Rattus norvegicus,Homo sapiens,vectors)
• Regulatory network for PACAP-responsive genes (2012, NA)
• Pathway map related to cisplatin-induced hepatotoxicity based on proteomic and genomic analysis (2012, Rattus norvegicus,Homo sapiens)
• Glucose metabolism in cancer cells (2012, NA)
• Regulation of cell death by glucose metabolism (2012, NA)
• Putative inhibitory pathway of LPS-activated inflammatory signaling responses by peptide K5 (2012, NA)
• Putative galanin-mediated neuronal pro- and antinociceptive mechanisms in the dorsal horn of the spinal cord (2012, Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens)
• Proposed p38 signal transduction pathways in thyroid cells and MCF-7 breast cancer cells based on data from the present study and previous reports (, ) (2012, NA)
• Novel YY1-miR-1 Regulatory Circuit in Skeletal Myogenesis Revealed by Genome-Wide Prediction of YY1-miRNA Network (2012, NA)
• Defects and mutations resulting in mucocutaneous candidiasis (2012, NA)
• Proposed model for IL-2–mediated reversal of T-cell tolerance through modulating Sirt1 expression (2012, Mus musculus,Homo sapiens)
• Diet and Energy-Sensing Inputs Affect TorC1-Mediated Axon Misrouting but Not TorC2-Directed Synapse Growth in a Drosophila Model of Tuberous Sclerosis (2012, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Drosophila simulans,Homo sapiens,Saccharomyces cerevisiae)
• Signaling pathways promoting trophoblast invasion and migration (2012, Homo sapiens)
• Schematic depicting mTORC1 signaling in a NAC a medium spiny neuron with anterogradely transported BDNF being released from a VTA dopamine neuron terminal and glutamate released from a prefrontal cortex projection neuron (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Recognition of Pathogenic Nucleic Acids by Patterns Recognition Receptors and Signaling (2012, NA)
• Involvement of the ERK pathway in the TGF-Beta-induced epithelial-mesenchymal transition (2012, NA)
• E6-mediated survival signaling (2012, NA)
• Extrinsic pathway of apoptosis (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Oryza sativa,Ovis aries,Anas platyrhynchos)
• According to these data in primary VSMCs we propose that BAY stimulates sGC and promotes synthesis of cGMP which directly activates PKG and phosphorylates VASP pSer239 thus inhibiting cell migration (Chen et al., ) (2012, NA)
• The roles of FGF/MAP kinase signaling in the formation of NANOG-positive epiblast cells or GATA6-positive hypoblast/primitive endoderm cells (2012, NA)
• The two main anabolic pathways, PTH and Wnt signaling, on osteoblasts, and indirectly on osteoclasts (2012, NA)
• Signaling and cross talk of the PTH and Wnt signaling pathways in osteocytes (2012, NA)
• T cell activation (2012, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Schematic display of the molecular interactions of apoptosis related molecules in dental apoptosis indicating the central position of the mitochondria pathway, which has been shown to be essential (2012, NA)
• Effects of VitA in gut-associated lymphoid tissue (2012, NA)
• Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location (2012, NA)
• Pathways for the synthesis of glycerolipids and their subcellular localization (2012, NA)
• Curation of phosphoproteomic profiling and bioinformatics delineates distinct tyrosine kinase signaling pathways in an oncogene-specific manner (2012, Homo sapiens,Mus musculus)
• Schematic depiction of proposed increased activation of ERK signaling pathway in SS RBCs (2012, NA)
• Proposed model for TIMP-1–mediated suppression of the Wnt/Beta-catenin pathway via let-7f in human mesenchymal stem cells (hMSCs) (2012, NA)
• Importance of cytokine signalling for CD4+ T-cell differentiation (2012, NA)
• Browsing the ApoptoProteomics database (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Analysis of the Fibroblast Growth Factor System Reveals Alterations in a Mouse Model of Spinal Muscular Atrophy (2012, Bos taurus,Oryctolagus cuniculus,Gallus gallus,Danio rerio,Xenopus laevis,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Armoracia rusticana)
• The pleiotropic effects of erythropoietin in infection and inflammation (2012, NA)
• An example showcasing the performance of SA in recovering the true structure using the IFGS compendium derived from GnRH signaling pathway in KEGG database (2012, NA)
• TLR4 signaling to NFKB (2012, NA)
• T-cell receptor (TCR) signaling to NFKB (2012, NA)
• Nucleotide excision repair (NER) pathway (2012, Saccharomyces cerevisiae,Pyrus communis,Homo sapiens,Mus musculus,Dipturus trachyderma,unidentified shuttle vector,Panthera tigris)
• Bi-potential gonad development to either testis or ovary (2012, Gallus gallus,Capra hircus,Paraechinus aethiopicus,Oryzias latipes,Dipnomorpha,Ornithorhynchus anatinus,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Known genes and pathways of the different cell types of the developing testis in mouse (modified from Wainwright and Wilhelm ) (2012, Gallus gallus,Capra hircus,Paraechinus aethiopicus,Oryzias latipes,Dipnomorpha,Ornithorhynchus anatinus,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• GSK-3 in NMDAR-LTD (2012, NA)
• Protein complexes and their connection with metabolism (2012, NA)
• Role of IAPs in DNA damage response (2012, Homo sapiens,Mus musculus,Drosophila melanogaster,Ovis aries,Chlamydia trachomatis)
• Regulation of cellular stress-induced cell death pathways by IAPs (2012, Homo sapiens,Mus musculus,Drosophila melanogaster,Ovis aries,Chlamydia trachomatis)
• Autophagy pathway: Molecular features (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Autophagy is initiated by stimuli that activate the phosphatidylinositol 3-phosphate kinase, Vps34 (2012, Hepatitis B virus,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,NA,NA)
• Summary diagram showing the role of ATG16L1 and NOD2 in the autophagy pathway and the defects observed when Crohn’s disease (CD) associated mutations are present (2012, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Escherichia coli LF82,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Measles morbillivirus,Vasconcellea candicans,Murine norovirus,Homo sapiens)
• Kinome-Wide Functional Genomics Screen Reveals a Novel Mechanism of TNFAlpha-Induced Nuclear Accumulation of the HIF-1A Transcription Factor in Cancer Cells (2012, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Behavioral and Immune Responses to Infection Require GAq- RhoA Signaling (2012, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Serratia marcescens,Microbacterium nematophilum,Saccharomyces cerevisiae,Cinchona pubescens,Drechmeria coniospora,Nematocida parisii,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• RNA-seq Reveals Novel Transcriptome of Genes and Their Isoforms in Human Pulmonary Microvascular Endothelial Cells Treated with Thrombin (2012, NA)
• Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination (2012, Homo sapiens,Mus musculus,unidentified,Dipturus trachyderma)
• Simplified view of the mTOR pathway (2012, Homo sapiens,Saccharomyces cerevisiae,Streptomyces hygroscopicus)
• MTOR pathway (2012, Homo sapiens,Saccharomyces cerevisiae,Streptomyces hygroscopicus)
• Mitochondrial-dependent apoptosis (2012, NA)
• Proposed model for the host translation regulation by HCV NS5A (2012, NA)
• Simplified diagram of the unfolded protein response (2012, NA)
• Proposed model for the inhibition of Notch1 signaling pathway by Fe65 (2012, Mus musculus,Homo sapiens)
• Changes in redox potentials and cellular function (2012, NA)
• Role of PHLPP in terminating oncogenic signaling pathways (2012, NA)
• Schematic overview of the different signaling steps involved in B(a)P-induced B2ADR-mediated [Ca2+]i induction in endothelial HMEC-1 cells (2012, NA)
• NFKB pathway: IKBs bind to functional NF-kB transcription factors (p50/p60) in cytoplasm in absence of stimuli and prevent their nuclear translocation (2012, Escherichia coli,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Mus musculus,Rattus norvegicus,Homo sapiens,Candida albicans)
• Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease (2012, Escherichia coli,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Mus musculus,Rattus norvegicus,Homo sapiens,Candida albicans)
• Nitric oxide signaling pathway regulating SVCT-2 expression and ascorbate uptake (2012, NA)
• RET/PTC-mediated TRAF activation (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities (2012, Homo sapiens)
• Timing and the potential mechanisms underlying remote ischemic conditioning (RIC) (2012, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• miR-23b and tretinoin, which was associated with this miRNA in thyroid cancer, shared the common target genes, ALDH1A1 and ALDH1A2 (2012, NA)
• Denitrification pathway (a) and regulation (b) in bacteria (2012, NA)
• Top network comparisons (2012, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Escherichia coli,Oryctolagus cuniculus,clinical samples)
• TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice (2012, NA)
• Gis1 and Rph1 Regulate Glycerol and Acetate Metabolism in Glucose Depleted Yeast Cells (2012, Homo sapiens,Saccharomyces cerevisiae,Macaca mulatta,Saccharomyces cerevisiae S288C,Mus musculus)
• Novel Classification of Lung Cancer into Molecular Subtypes (2012, NA)
• Matrix-Bound PAI-1 Supports Cell Blebbing via RhoA/ROCK1 Signaling (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Triticum aestivum)
• Sequential pathway leading to renal ischemia-reperfusion injury (2012, NA)
• Schematic signal pathway by siRNA targeting AIMP2-DX2 in NCI-H460 cells (2012, NA)
• Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis (2012, NA)
• Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis (2012, NA)
• Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis (2012, NA)
• Lck is a central node in the T cell receptor signaling pathway (2012, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling (2012, NA)
• Drosophila signaling pathways that regulate humoral responses (2012, Drosophila melanogaster,Homo sapiens)
• Proposed mechanism for FTY720-stimulated Beta-cell regeneration in vivo (2012, NA)
• Schematic presentation of the ROS-DAPK-PKD1-GLUT4 axis as a novel pathway involved in contraction-induced glucose but not LCFA uptake (2012, Mus musculus,Rattus norvegicus,Candida dubliniensis,Homo sapiens)
• Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium (2012, NA)
• Wnt/Beta-catenin signalling and Beta-catenin role in adhesion in glioma cells (2012, Homo sapiens,Mus musculus)
• Cell-line subtypes have unique SuperPathway network features (2012, NA)
• Pathway diagrams can be used to predict response to therapies (2012, NA)
• Signaling through CD44: hyaluronan binding to a receptor such as CD44 or RHAMM will cause a conformational change in the receptor (2012, NA)
• The anatomic and molecular mechanisms of sepsis-mediated sympathoexcitation and ghrelin's anti-inflammatory effect via sympathoinhibition (2012, NA)
• Working model of ID/anemia-suppressed hippocampal IGF signaling (2012, NA)
• Chronic JNK signaling dominates over AKT signaling and overrides the inhibitory effect of AKT on FOXO3a for the transcription of its effectors, BNIP3 and MurF-1 in POH and in heart failure (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• IPA illustrating the predicted effect of milk removal on PI3K signaling in T lymphocytes (2012, NA)
• AP complement activation and order of events in elastase-induced AAA disease (2012, Mus musculus,Homo sapiens)
• A, Hepatic BCAA metabolism (2012, NA)
• Signaling pathways possibly involved in the interplay between cell death and cytoprotection processes in yeast cells in response to acetic acid stress (2012, Saccharomyces cerevisiae,Saccharomyces cerevisiae W303,Zygosaccharomyces bailii,Homo sapiens,Mus musculus,Artemia franciscana)
• Endocrine actions of FGF15 (2012, NA)
• Anti-inflammatory actions of 15dPGJ2 in T (2012, Trypanosoma cruzi,Homo sapiens)
• Selected essential fatty acids molecular mechanisms (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Candida dubliniensis,NA)
• Proposed role of essential fatty acids in “micromanaging” molecular actions (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Candida dubliniensis,NA)
• Decrease of miR-146b-5p in Monocytes during Obesity Is Associated with Loss of the Anti-Inflammatory but Not Insulin Signaling Action of Adiponectin (2012, Homo sapiens,Mus musculus,Escherichia coli,Armoracia rusticana,Sus scrofa)
• TLR signalling pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Possible implication of UPR in inflammatory response (2012, NA)
• Proposed schematic diagram for of EA-induced analgesia in normal rats (2012, NA)
• Chlamydomonas fermentative pathways under dark anoxic conditions (2012, NA)
• Function-Based Discovery of Significant Transcriptional Temporal Patterns in Insulin Stimulated Muscle Cells (2012, NA)
• General scheme for biogenesis of Fe-S clusters in mammalian cells (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Danio rerio)
• Proposed differences in the localization of Fe-S cluster biogenesis proteins in S (2012, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Danio rerio)
• Targeting the p53 signaling pathway in cancer therapy - The promises, challenges, and perils (2012, Human papillomavirus types,Human adenovirus sp.,Homo sapiens,Mus musculus,vectors)
• Proposed model of molecular mechanism of SW-induced apoptosis in A549 cells (2012, NA)
• MTOR signalling pathway (see text for details) (2012, Homo sapiens)
• Metabolic switch in carbon source for lipid synthesis (2012, NA)
• Gene functional association networks for selected pathways in p53 dataset (2012, NA)
• Top scored pathway map affected by BaP "Apoptosis and survival_Endoplasmic reticulum stress response" (2012, Oikopleura dioica,Homo sapiens)
• Agent classes and functions in necrotizing enterocolitis (NEC) agent-based model (ABM) and schematic for Hill equations (2012, NA)
• Diagram shows the enzyme points (in cycle) on which the effects of n-3 PUFA might operate in the homocysteine metabolic pathway of relevance (2012, NA)
• The Wnt signaling pathway in cancer cells (2012, NA)
• Role of the Wnt signaling pathway in prostate cancer bone metastasis (2012, NA)
• EMT downstream of TGFB and HMGA2 (2012, Mus musculus,Homo sapiens)
• A, hypothetical model of d-glucose-dependent NO-mediated iron mobilization from cells (2012, NA)
• Control of the EGFR pathway and cell cycle entry by miRNAs (2012, NA)
• KEGG pathway mapping overlay for acidic pHe upregulated genes pertinent to OXPHOS (2012, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Homo sapiens)
• Into the Eye of the Cytokine Storm (2012, Influenza A virus,H5N1 subtype,Homo sapiens)
• Mechanisms of control of Listeria entry by the type IA PI 3-kinase signaling pathway (2012, Listeria monocytogenes,Homo sapiens)
• The signaling pathway showing the possible role for cyclic-AMP responsive element binding (CREB) protein and CREB-binding protein (CBP) in the epigenetic regulation of gene expression (2012, NA)
• The signalling induced by salt stress and biotic stress (as induced by the Harpin elicitor) in grapevine (2012, NA)
• JAK-STAT intracellular signaling pathway in myelofibrosis (2012, NA)
• Pathway model for interleukin (IL)-1A and tumor necrosis factor (TNF)-Alpha-induced inhibition of human skeletal muscle cell (HuSKMC) differentiation (2012, NA)
• Possible signaling pathways of EPCs senescence (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Interactions between insulin-like growth factor-1 receptor (IGF-1R), insulin receptor (IR), and epidermal growth factor receptor (EGFR) signaling pathways (2012, NA)
• Pathways involved in diabetes-induced EPCs toxicity and possible strategies to reverse EPCs damage during bone marrow mobilization (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Intrinsic and exrtinsic pathways of anoikis (2012, Homo sapiens,Mus musculus)
• Possible mechanisms that make the diabetic heart more or less susceptible to infarction following ischemia reperfusion (2012, NA)
• Arginine metabolic network (2012, NA)
• Working model of diabetes-associated accelerated atherothrombosis (2012, NA)
• Schematic of signaling pathways activated by the Rho GTPases in macrophages (2012, NA)
• Differences in signal reconstruction of a selected portion of the insulin signaling pathway of KEGG (hsa04910) (2012, Homo sapiens)
• Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development (2012, NA)
• Targeting Bone Remodeling by Isoflavone and 3,3′-Diindolylmethane in the Context of Prostate Cancer Bone Metastasis (2012, Glycine max,Sequoia sempervirens,Homo sapiens,Mus musculus,Bos taurus)
• Oncogenes and tumor suppressors associated with the regulation of autophagy (2012, NA)
• Innate immunity and the ubiquitin–proteasome system in PD (2012, NA)
• Proximal signaling pathways upon stimulation of immune receptors in B and T cells (2012, NA)
• Biological interaction networking of PSME1 and RPS12 in chronic atrophic gastritis (CAG) (2012, Helicobacter pylori,Homo sapiens)
• Simplified schematic diagram of skeletal muscle protein synthesis following exercise (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Triticum aestivum)
• Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line (2012, Oryctolagus cuniculus,Capra hircus,Equus caballus,Tragelaphus oryx,Homo sapiens,Mus musculus,Paracentrotus lividus)
• The interactions between the Hippo and Wnt/Beta-catenin signalling pathways, based on , and this study (2012, NA)
• Consequences of lamin B1 accumulation on redox balance, senescence and neurological defects (2012, NA)
• Depletion of PERK, PI3K p110A, and LRP1 but not caspase-8 reduces phox-ER stress-induced immunogenicity (2012, NA)
• Shugoshins function as a guardian for chromosomal stability in nuclear division (2012, Saccharomyces cerevisiae,Homo sapiens)
• Proposed model to illustrate the signaling pathways involved in MMP-9 expression in RBA-1 cells infected with JEV (2012, NA)
• Tentative scheme for luteolin regulation of the IGF-IR signaling pathway in HT-29 human colon cancer cells (2012, NA)
• Molecular mechanisms of HGF-c-Met-mediated signaling for inhibiting TLR4-mediated NFKB activation in macrophages (2012, NA)
• Pathophysiology of muscular insulin resistance: normal (a) and impaired (b) insulin signalling pathway (from , reprint with kind permission of Elsevier Limited) (2012, Oryza sativa,Zea mays,Solanum tuberosum,Olea europaea,Homo sapiens,Osphranter robustus,Tringa semipalmata)
• Molecular mechanisms of fungal biofilm resistance (2012, NA)
• Signaling by PERK, IRE1, and ATF6 (2012, NA)
• Diagrammatic representation of the Akt signaling pathway.Notes: Activation of receptor tyrosine kinase (RTK) by growth factor binding activates PIK3 (2012, Homo sapiens,Mus musculus)
• Signaling cascade following TLR2/TLR4, TLR7/TLR8, and TLR3 activation with envelope glycoprotein, ssRNA, and dsRNA, respectively (2012, NA)
• Left half, signaling via IPS-1 following dsRNA/ssRNA recognition by RIG-I and MDA5 (2012, NA)
• How BRG1 and CHD4 antagonistically influence Wnt signaling during yolk sac vascular development (2012, Mus musculus,Homo sapiens)
• Hypoxia Reduces Arylsulfatase B Activity and Silencing Arylsulfatase B Replicates and Mediates the Effects of Hypoxia (2012, NA)
• Myostatin signals through the ActRIIB-ALK4/5 heterodimer activate Smad2/3 with blocking of MyoD transactivation in an autoregulatory feedback loop (2012, Mus musculus,Rattus norvegicus,Zea mays,Malus domestica,Homo sapiens,Bos taurus)
• Ang-(1-7) signaling in cardiomyocytes (2012, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways in the pathogenesis of nasopharyngeal carcinoma (NPC) (2012, NA)
• Hyperglycemia-induced endothelial dysfunction and activation (2012, Homo sapiens)
• Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis (2012, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Severe acute respiratory syndrome-related coronavirus,unidentified influenza virus,Respiratory syncytial virus,Human betaherpesvirus 5,H1N1 subtype,H5N1 subtype,Enterovirus A71,Coxsackievirus,Enterovirus,Human rhinovirus sp.,Influenza A virus H3N2,Human metapneumovirus,Echovirus,H11N9 subtype,Human bocavirus,Homo sapiens,Mus musculus,Sus scrofa,unidentified,Venustaconcha ellipsiformis,Derris trifoliata,NA,NA,NA)
• AKT signaling pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Coregonus peled)
• PI3K/AKT signaling module and cross-talk with other pathway (2012, NA)
• Regulatory function of TRAP1 in the crosstalk between mitochondrial and endoplasmic reticulum (2012, NA)
• Association of the canonical interferon pathway with the IRF5 haplotype (2012, NA)
• Sixteen genes associated with enzastaurin response were established by pathway analyses and prediction of drug response using an eight-gene signature (2012, NA)
• ABPP processing, the adaptor proteins interacting with its intracellular domain and the pathway leading to ERK1/2 activation (2012, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• The intracellular pathway by which ABPP and PS1 control the activation of the MAPK/ERK1/2 cascade and their final biological effects (2012, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Summarized the signaling mechanisms of various matricellular proteins contributing to cancer progression (2012, NA)
• JNK signaling pathway in the mammalian brain (2012, NA)
• JNK signaling pathway regulates axonal transport and autophagy (2012, NA)
• Differential regulation of fibrogenic phospho-Smad signaling between HSC during acute liver injury and MFB during chronic liver injury (2012, Homo sapiens,Rattus norvegicus,Hepatitis B virus)
• The regulation of Wnt pathway by malin and laforin (2012, Homo sapiens)
• Phosphatidylinositol 3-Kinase Plays a Vital Role in Regulation of Rice Seed Vigor via Altering NADPH Oxidase Activity (2012, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Glycine max,Embryophyta,Raphanus sativus,Panicum virgatum,Dianthus caryophyllus,Spirodela polyrhiza,Lolium rigidum,Chlamydomonas moewusii,Lemna gibba,Graptopetalum paraguayense,Homo sapiens,Oryctolagus cuniculus,Weizmannia coagulans)
• Future of targeted agents in metastatic colorectal cancer (2012, NA)
• Future of targeted agents in metastatic colorectal cancer (2012, NA)
• Parp1 mediation of Sox2 activity in ESC pluripotency (2012, Homo sapiens,Mus musculus)
• The functional role of Akt1, EMSY, and BRCA2 in the regulation of ISGs (2012, Human alphaherpesvirus 1,Vesicular stomatitis virus,Mus musculus,Homo sapiens)
• Regulation of ISGs by Akt1 and EMSY (2012, Human alphaherpesvirus 1,Vesicular stomatitis virus,Mus musculus,Homo sapiens)
• Insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) is a major candidate pathway in human longevity (2012, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Interaction motifs and domains of RANKL signal intermediaries (2012, Homo sapiens,Mus musculus,Measles morbillivirus)
• p62 in osteoclast signaling and protein trafficking (2012, Homo sapiens,Mus musculus,Measles morbillivirus)
• Folate Decorated Dual Drug Loaded Nanoparticle: Role of Curcumin in Enhancing Therapeutic Potential of Nutlin-3a by Reversing Multidrug Resistance (2012, Armoracia rusticana,Curcuma longa,Homo sapiens,Mus musculus,Bos taurus,Apamea zeta)
• Interactions of signaling by ER stress, oxidative stress, and cytokines with the pathways of autophagy: Induction of autophagy requires the assembly of Beclin-1 with class III PI 3 kinase (Vps34) and UVRAG (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Moloney murine leukemia virus)
• BDNF signaling through TrkB receptors (2012, NA)
• Progesterone Receptor Activates Msx2 Expression by Downregulating TNAP/Akp2 and Activating the Bmp Pathway in EpH4 Mouse Mammary Epithelial Cells (2012, NA)
• Muscle cell signaling in response to 1E3 (2012, Mus musculus,Homo sapiens)
• PepT1-nucleotide-binding oligomerization domain (NOD) pathway (2012, NA)
• Diagram of ouabain/EO-activated, A2 Na+ pump/Src-mediated signaling cascade (the EO/A2 Na+ pump signalosome) (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Scheme for the intracellular renal RAS on the nuclear membrane (2012, NA)
• Mitochondrial regulation of apoptosis (2012, NA)
• Glucose and fructose metabolism in P (2012, NA)
• This figure shows three novel intracellular signaling pathways involved in the pathogenesis of IBD (2012, NA)
• Summary of GILZ's regulatory effects on the AKT pathway in BCR-ABL cells (2012, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Schimatic signaling pathway for the AT1-mediated, NOX2-derived ROS production (2012, NA)
• Schematic view of potential targets and site of action of some biologics in IBD (2012, NA)
• Positive selection of nonautoreactive immature B cells into the peripheral B-cell compartment requires a threshold level of tonic BCR signaling (2012, NA)
• Genetic pathways involved in the regulation of the Mesp2 pathway (2012, Mus musculus,Homo sapiens)
• Network analysis of proteomics using IPA (2012, NA)
• Reaction sequences leading to attenuated arrhythmias (2012, NA)
• The possible mechanism of JAK2/STAT3 signalling in the apoptosis of CRC (2012, NA)
• Genes identified as part of the significant Para-ICA networks highlighted on a KEGG Alzheimer’s pathway diagram derived from the DAVID functional association tool (2012, Homo sapiens,Lama glama)
• Networks built using differentially expressed genes in uninfected macrophages from C57BL/6 and CBA mice (2012, Leishmania amazonensis,Homo sapiens)
• Associations between HIV and Human Pathways Revealed by Protein-Protein Interactions and Correlated Gene Expression Profiles (2012, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,Bacillus anthracis,Francisella tularensis,Yersinia pestis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Interaction between the Cockayne syndrome B and p53 proteins: implications for aging (2012, Homo sapiens,Mus musculus,Human adenovirus 12)
• Scheme of the endothelial angiopoietin (Angpt)/Tie2 system highlighting fundamental signalling pathways (2012, Homo sapiens,Mus musculus,Bacillus anthracis,NA)
• Working model for the proliferative, prosurvival, and migratory roles of TRPM8 in pancreatic adenocarcinoma cells (2012, Homo sapiens,Mus musculus,Danio rerio)
• Working model for the signaling mechanisms that mediate the cellular functions of TRPM7 in pancreatic adenocarcinoma (2012, Homo sapiens,Mus musculus,Danio rerio)
• Cell death signaling by the ER stress response/UPR (2012, Homo sapiens)
• Proposed effects of IGFBP1 on vascular endothelial cells (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Simian endogenous retrovirus)
• An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated AB oligomers (2012, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis)
• Multistep activation of the Helicobacter pylori effector CagA (2012, Helicobacter pylori)
• Parkinson’s disease: don’t mess with calcium (2012, NA)
• Methamphetamine Causes Differential Alterations in Gene Expression and Patterns of Histone Acetylation/Hypoacetylation in the Rat Nucleus Accumbens (2012, NA)
• Insect Neuropeptide Bursicon Homodimers Induce Innate Immune and Stress Genes during Molting by Activating the NFKB Transcription Factor Relish (2012, NA)
• Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress in Human Prostate Cancer Cells by n-butylidenephthalide (2012, Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Zea mays,Angelica sinensis,Homo sapiens,Mus musculus,Hepatitis B virus)
• Graphical representation of the model NF-signalling network detailed in (2012, NA)
• Potential mechanisms by which resistin may mediate cardiovascular dysfunction (2012, NA)
• C/EBP in neurite regeneration (2012, Mus musculus,Rattus norvegicus,Cricetus cricetus,Caenorhabditis elegans,Lymnaea stagnalis,Homo sapiens,Diaporthe sclerotioides)
• PI3K/Akt/mTOR signaling pathway (2012, Streptomyces hygroscopicus,Leptospira kmetyi,Homo sapiens,Mus musculus,Nicotiana tabacum)
• HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling (2012, Saccharomyces cerevisiae,Armoracia rusticana,Zea mays,Diaporthe sclerotioides,Matthiola incana,Human immunodeficiency virus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Metabolic processes of Rhodococcus sp (2012, Escherichia coli,Pseudomonas aeruginosa,Corynebacterium glutamicum,Pseudomonas fluorescens,Synechococcus elongatus PCC 7942 FACHB-805,Rhodococcus sp. in high GC Gram-positive bacteria,Alcaligenes faecalis,Rhodococcus sp. NAU-1,Saccharomyces cerevisiae,Zea mays,Spinacia oleracea,Homo sapiens)
• Putative intracellular cascades activated by cyclic di‐nucleotides (2012, NA)
• Loss of PTEN Is Not Associated with Poor Survival in Newly Diagnosed Glioblastoma Patients of the Temozolomide Era (2012, Homo sapiens,Mus musculus)
• JAK/STAT signaling pathway (2012, NA)
• JAK/STAT signaling pathway targeted by different inhibitors (2012, NA)
• Significant differences in mRNA expression were seen for genes involved in the JNK signaling pathway between tumors arising in different CNS locations (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• AKT-mTOR signaling pathway showing rapamycin inhibition sites in astrocytomas (2012, NA)
• Altered signaling pathways and inhibitors (2012, NA)
• The activation of TLR2 by Leishmania sp., leading to a proinflammatory (left), or anti-inflammatory arm (centre and right) (2012, NA)
• Proposed models for the activation of intracellular TLR9 and TLR3 by Leishmania (2012, NA)
• New therapeutic approaches based on targeted biologic agents have generated great interest and are currently being investigated in several clinical trials focused on treatments for recurrent ovarian cancer () (2012, Homo sapiens,Mus musculus,NA)
• Metabolism of xenobiotics by cytochrome P450 pathway, and ribosome map views of identified proteins (2012, Mus musculus,Rattus norvegicus,Arabidopsis thaliana,Eucalyptus intertexta,Homo sapiens,unidentified)
• Structure of the ERK pathway (adapted from http://www.sabiosciences.com/) (2012, Clostridioides difficile,Clostridioides difficile CD3,Streptomyces tsukubensis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nigella sativa,Homo sapiens,Gallus gallus)
• JNK signalling pathway (adapted from http://www.sabiosciences.com/) (2012, Clostridioides difficile,Clostridioides difficile CD3,Streptomyces tsukubensis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nigella sativa,Homo sapiens,Gallus gallus)
• P38 signalling cascade (adapted from http://www.sabiosciences.com/) (2012, Clostridioides difficile,Clostridioides difficile CD3,Streptomyces tsukubensis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nigella sativa,Homo sapiens,Gallus gallus)
• Alternative signaling in the presence of cyclosporine A (2012, Clostridioides difficile,Clostridioides difficile CD3,Streptomyces tsukubensis,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nigella sativa,Homo sapiens,Gallus gallus)
• Simplified scheme of cell death and survival pathways involved in ALF (2012, NA)
• Strain-specific host gene networks activated in Mtb-infected BMM (2012, NA)
• Renaissance in medical biochemistry – Hepatology and Endocrinology kick it up a Notch! (2012, Homo sapiens,Mus musculus)
• Schematic proposal for the mechanism responsible for syringaresinol-induced vasorelaxation (2012, NA)
• Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes (2012, NA)
• Nuclear Factor Kappa B Activation Occurs in the Amnion Prior to Labour Onset and Modulates the Expression of Numerous Labour Associated Genes (2012, NA)
• (R,R)ZX-5 promotes choroidal blood flow through PI3K/Akt and Akt-Ca2+-eNOS pathway and inhibits CNV through inhibiting angiogenesis (2012, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Gallus gallus,Diaporthe sclerotioides)
• RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer (2012, Mus musculus,Escherichia coli,Glycine max,Triticum aestivum,Cricetus cricetus,Escherichia coli IS5,Homo sapiens,Oryctolagus cuniculus)
• Crosstalk among Ras, PKCζ/PKCD and the mTOR signaling pathway(s) regulating calcineurin inhibitor (CNI)-induced VEGF overexpression in renal cancer cells (2012, NA)
• Signaling pathways involved in anthracycline-induced cardiomyocyte injury (2012, NA)
• Involvement of PI3K and NFKB pathways in the apoptosis delay in A (2012, NA)
• Subnetwork of functional interactions of ESRP-target networks (2012, NA)
• Summary model of rAdV-sensing cascades in RAW 264.7 cell line (2012, NA)
• Calcium-mediated induction of myocardin expression in VSMCs (2012, NA)
• Proposed model for the role of SPHK/phyto-S1P and PLDA1/PA in the ABA-mediated stomatal closure signaling pathway (2012, Arabidopsis thaliana)
• ABHD6 is strategically positioned to regulate 2-AG levels at the site of its generation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Cannabis sativa,Streptomyces lividans)
• Wnt signaling regulation induced by cell surface HSPG desulfation during dentinogenesis (2012, Mus musculus,Homo sapiens)
• Apoptotic cascade (2012, NA)
• Proposed mechanism for overcoming HNSCC resistance to EGFR antagonists using PI3kinase/Akt/mTOR and NFKB-IL6-STAT3 pathway inhibitors (2012, NA)
• Coregulation of gene transcription by p53 and Smad complexes (2012, NA)
• Canonical and noncanonical pathways of NFKB activation (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Chronic production of inflammatory mediators by microglial cells, particularly the generation of ROS and NO by activated microglia, mediates the majority of DA-neuronal degeneration and cell death (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathway-Based Evaluation in Early Onset Colorectal Cancer Suggests Focal Adhesion and Immunosuppression along with Epithelial-Mesenchymal Transition (2012, NA)
• Role of miR-148a in Hepatitis B Associated Hepatocellular Carcinoma (2012, NA)
• JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells (2012, NA)
• cAMP Signaling CascadeLigand binding (represented in this example by PTH, but other ligands and receptors can stimulate cAMP synthesis), activates GsA and stimulates cAMP synthesis by adenylate cyclase (2012, NA)
• Hypothetical model for neuroimmune-related actions of miRNAs in brain of human alcoholics (e.g., in microglia) (2012, NA)
• TGFB signaling pathway overlaid with differentially expressed genes (2012, NA)
• Enrichment and submodularization of cell cycle in terms of E3-mediated regulatory modules (2012, NA)
• Pathways required for the role of CDCP1 in EGF/EGFR-induced cell morphological changes and increased cell migration (2012, NA)
• Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus (2012, NA)
• Common Genetic Denominators for Ca++-Based Skeleton in Metazoa: Role of Osteoclast-Stimulating Factor and of Carbonic Anhydrase in a Calcareous Sponge (2012, Metazoa,Drosophila melanogaster,Caenorhabditis elegans,Tribolium castaneum,Ciona intestinalis,Branchiostoma lanceolatum,Deuterostomia,Branchiostoma floridae,Mytilus galloprovincialis,Hydra vulgaris,Artemia salina,Acropora millepora,Suberites domuncula,Stylophora pistillata,Carcinus maenas,Geodia cydonium,Sycon ciliatum,Harpegnathos saltator,Millepora dichotoma,Sycon raphanus,Stelletta grubii,Monorhaphis chuni,Astrosclera willeyana,Danio rerio,Xenopus laevis,Dipturus trachyderma,Squalus acanthias,Oryctolagus cuniculus,Arabidopsis thaliana,Capra hircus,Diaporthe sclerotioides,Matthiola incana,Cervus elaphus,Homo sapiens,Mus musculus,Escherichia coli,Tequatrovirus T4,NA)
• TLR signalling (2012, NA)
• Feedback inhibition mediated by the PI3K/AKT/mTOR pathway (2012, NA)
• Graphical representation of the known connections between the Wnt/Beta-catenin pathway and the Notch1 signaling pathways, according to the knowledge of the current literature (2012, NA)
• Annotation of the insulin/TOR network in Apis showing methylated and differentially methylated genes (2012, Apis mellifera)
• Insulin receptor (INSR) belongs to a family of receptor tyrosine kinases that includes the receptor for insulin-like growth factor 1 (IGF-1R) (2012, Homo sapiens,Mus musculus,Gallus gallus)
• Stress-elicited extrinsic phenotypes (2012, NA)
• Binding of the TNFA ligand to its receptor, TNFR1, leads to recruitment of TNF receptor-associated death domain (TRADD) (2012, NA)
• Simplified TGFB pathway (2012, West Nile virus,Homo sapiens)
• Pivotal role of E-cadherin, Beta-catenin, and transforming growth factor B (TGFB) and Wnt signaling pathways in an epithelial-mesenchymal transition (EMT) program (2012, NA)
• ALDH1A1 pathway (2012, NA)
• NOS3 pathway (2012, NA)
• Mammalian target of rapamycin pathway is deregulated by mutations in cancer (2012, NA)
• Targeting Mnks for Cancer Therapy (2012, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Drosophila melanogaster,NA)
• Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes (2012, Homo sapiens,Mus musculus,Bos taurus)
• Schematic representation of the Id2-induced cellular proliferation pathway in SCC (2012, NA)
• IGFBP5 enters cells through its own surface receptor or by freely diffusing into the cytoplasm (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Antarctothoa delta)
• Niclosamide targets the Wnt/Beta-catenin, Notch, and mTORC1 pathways (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Hymenolepis diminuta)
• Hypothetic diagram of high-mobility group box protein 1 (HMGB1)-mediated upregulation of vascular endothelial growth factor (VEGF)-A in retinal ganglion cell (RGC)-5 cells in response to advanced glycation end products (AGEs) stimulation (2012, NA)
• Recruiting a New Substrate for Triacylglycerol Synthesis in Plants: The Monoacylglycerol Acyltransferase Pathway (2012, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Glycine max,Arachis hypogaea,Brassica napus,Nicotiana benthamiana,Saccharomyces cerevisiae S288C,Carthamus tinctorius,Abelmoschus esculentus,Hibiscus cannabinus,Homo sapiens,Mus musculus,Bos taurus,Caenorhabditis elegans,Tomato bushy stunt virus)
• Long-term memory formation is linked to circadian time and the suprachiasmatic nucleus (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Retinoid absorption, transport, and metabolism (2012, Nicotiana tabacum,Daucus carota,Citrus deliciosa,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Gallus gallus)
• Molecular changes of serous carcinogenesis (2012, NA)
• Scheme showing the essential functions of Notch in blood and vascular cell types (a) Osteocyte Dll/Jag-induced Notch signaling in hematopoietic stem cells (HSCs) is involved in their generation and self-renewal in the adult (2012, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio,Prevotella sp.)
• Identification of Protein Networks Involved in the Disease Course of Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Exercise-stimulated glucose uptake in skeletal muscle (2012, NA)
• Molecular pathways affected by panobinostat and sorafenib (2012, NA)
• Major molecular pathways mediating cholangiocyte proliferation (2012, NA)
• Beyond inactivation of the MEN1 gene, additional mutations in other genes may be responsible for acceleration of tumor growth, thus involving a process of multistep tumorigenesis (2012, NA)
• Proposed pathway (2012, Homo sapiens)
• ROS-dependent and -independent apoptosis induced by particulate pollutants (2012, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Caenorhabditis elegans,Nicotiana tabacum)
• Physiological and pathophysiological stimuli regulate tonicity-responsive enhanced binding protein (TonEBP) in diverse cell types (2012, NA)
• Cbl-b functions as central gate keeper of T-cell activation (2012, NA)
• Diagram of canonical actin cytoskeleton signaling pathway (2012, Rattus norvegicus,Homo sapiens)
• Ethanol-Mediated Regulation of Cytochrome P450 2A6 Expression in Monocytes: Role of Oxidative Stress-Mediated PKC/MEK/Nrf2 Pathway (2012, NA)
• Model mechanism on the ability of piceatannol to induce apoptosis and suppress cell proliferation in CaP cells is proposed (2012, NA)
• Corticostriatal long-term depression (LTD) (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Pollachius pollachius)
• mTOR pathway in aging (2012, Homo sapiens,Mus musculus)
• Top Networks Associated With MK-801 Treatment Identified by Ingenuity Pathway Analysis (2012, NA)
• Schematic diagram illustrating intracellular signaling cascade that may mediate feedback inhibition of AT1R expression via inhibition of protein kinase G (PKG) pathway (2012, NA)
• Major signalling pathways identified in ischaemic postconditioning (PostC) (2012, NA)
• Regulation of hepcidin by iron and inflammation (2012, NA)
• Examples of pattern recognition in ancient symbioses (2012, NA)
• Regulation of muscle glucose uptake and glycogen synthesis by insulin and contraction (2012, NA)
• Tumor suppressors and oncogenes in the Wnt pathway (2012, Homo sapiens,Mus musculus)
• Human epidermal growth factor receptor (HER) 2 signaling pathways involved in tumorigenesis and cardiac survival (2012, Homo sapiens)
• Concordance of Changes in Metabolic Pathways Based on Plasma Metabolomics and Skeletal Muscle Transcriptomics in Type 1 Diabetes (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryza sativa,Canis lupus familiaris)
• Wnt signaling pathway participated in the activation of hepatic stellate cells (2012, NA)
• TGFB signaling pathway members and potential pathway member LRG1 (2012, NA)
• Tau neuroinflammatory cascade (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• T Regulatory Cells Control Susceptibility to Invasive Pneumococcal Pneumonia in Mice (2012, Oryctolagus cuniculus,Equus caballus,Middle East respiratory syndrome-related coronavirus,Streptococcus pneumoniae,West Nile virus,Streptococcus pneumoniae D39,Homo sapiens,Mus musculus,Armoracia rusticana,Leishmania major)
• Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing (2012, Ruditapes philippinarum,Homo sapiens)
• Schematic presentation depicting the regulation of receptor signaling through G-proteins (2012, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens)
• Intracellular signalling pathways that are activated by insulin and amino acids after feeding and that lead to the activation of translation initiation in the immature skeletal muscle (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,Hevea brasiliensis)
• DEGs in cell cycle pathway Up-regulated and down-regulated DEGs are highlighted in red and green, respectively (2012, Homo sapiens,Mus musculus,Vitis vinifera,Panthera tigris)
• DEGs in p53 signaling pathway Up-regulated and down-regulated genes are color-coded in red and green, respectively (2012, Homo sapiens,Mus musculus,Vitis vinifera,Panthera tigris)
• RAF/MEK dependence of KRAS mutant pancreatic ductal adenocarcinomas (2012, NA)
• MAPK signalling pathway with unstable and stable (copy number and expression) genes represented (2012, NA)
• miRNA deregulation in cancer (2012, NA)
• Cyclophosphamide (CTX)‐mediated immunomodulation on the basis of genes up‐regulated by treatment (2012, Homo sapiens,Mus musculus)
• Cotinine's potentiation of the A7 nAChR (2012, NA)
• PI3K/Akt signal pathway is crucial to SDF1/CXCR-mediated homing of endothelial progenitor cells (EPCs) after myocardiac infarction (2012, Bos taurus,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Gallus gallus)
• GPR30-mediated signaling (2012, Mus musculus,Homo sapiens)
• Cno is a novel regulator of the Slit-Robo signaling pathway (2012, Drosophila melanogaster,Homo sapiens)
• siRNA screening identifies TrkB, TrkC, and FGFR1 (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• The involvement of APPL1 in synaptic NMDA receptor-dependent neuroprotection (2012, Mus musculus,Rattus norvegicus,Homo sapiens)
• Effect of BDNF/TrkB and downstream signaling pathways on central sensitization following C-fiber activity (2012, NA)
• Transcriptomics of In Vitro Immune-Stimulated Hemocytes from the Manila Clam Ruditapes philippinarum Using High-Throughput Sequencing (2012, Ruditapes philippinarum,Homo sapiens)
• Paths to stemness: building the ultimate antitumour T cell (2012, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Panthera leo)
• Black-Box Illuminated: Signals and Signaling (2012, Drosophila melanogaster,Antarctothoa delta,Homo sapiens,Mus musculus,Corynephage beta)
• Recognition of particulate and soluble Beta-glucans by dectin-1 and signal transduction in macrophages and DCs (2012, NA)
• Acute metabolic effects of AMPK activation (2012, Saccharomyces cerevisiae,Candida dubliniensis,herbal medicine,Schizosaccharomyces pombe,Curcuma longa,Allium sativum,Capsicum frutescens,Galega officinalis,Bos taurus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Sequoia sempervirens)
• Unique Combination of Male Germ Cell miRNAs Coordinates Gonocyte Differentiation (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Sequoia sempervirens)
• T cell differentiation (2012, NA)
• Signaling pathways linking EphA and RhoA in regulation of cell adhesion/repulsion (2012, NA)
• Mechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK Activation (2012, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Synthetic Pathway for Compound 9–11 (2012, NA)
• Illustration of p53 TIAs in lymphocytes (2012, Homo sapiens)
• Natural inhibitors of coagulation and anticoagulant drugs.TF, tissue factor; VKA, vitamin K antagonists; AT, antithrombin; APC, activated protein C; TFPI, tissue factor pathway inhibitor type-1 (2012, NA)
• Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease (2012, NA)
• MTOR signaling pathway (2012, Homo sapiens)
• Therapeutic modulation of the TP53 pathway (2012, Homo sapiens)
• MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells (2012, NA)
• TGFB antagonists and inhibitors (2012, Homo sapiens)
• TGFB and tumor suppression (2012, Homo sapiens)
• Multiple TGFB signaling pathways (2012, Homo sapiens)
• TGFB/Smad canonical signaling pathway (2012, Homo sapiens)
• Signalling pathways modulated by NF1 (2012, NA)
• Reduced Expression of Inflammatory Genes in Deceased Donor Kidneys Undergoing Pulsatile Pump Preservation (2012, NA)
• Gene Expression Analysis Implicates a Death Receptor Pathway in Schizophrenia Pathology (2012, NA)
• Regulatory network of Katanin protein (2012, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Vigna angularis,Drosophila melanogaster,Caenorhabditis elegans,Trypanosoma brucei,Leishmania major,Danio rerio,Xenopus laevis,Xenopus tropicalis,Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• EGFR signalling pathway (2012, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Hh pathway critical components which could be targeted by potential antibasal cell carcinoma drugs.Notes: The mechanism of action of each single drug is explained in the text (2012, NA)
• The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension (2012, NA)
• Double-strand break repair in mammalian cells (2012, NA)
• Melanoma: New Insights and New Therapies (2012, NA)
• Schematic model of signaling pathways implicated in tumor cell VM (2012, Homo sapiens)
• NFKB pathway induces glucose import to support survival of B-cell lymphomas; autophagy prolongs survival after NFKB inhibition (2012, NA)
• The regulation of Torso- and EGFR-dependent responses in the Drosophila blastoderm embryo (2012, NA)
• Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer (2012, Homo sapiens,Mus musculus)
• Early determination of Teff cell fate versus TFH cell fate controlled by TCR signal strength (2012, NA)
• Regulation of early TH2 differentiation by TCR signal strength (2012, NA)
• Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation (2012, Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Shigella flexneri,Citrobacter rodentium,Mus musculus,Rattus norvegicus,Homo sapiens,Panthera tigris)
• Putative inhibitory pathway of inflammatory signaling events by CA (2012, NA)
• BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NFKB pathway (2012, Mus musculus,Rattus norvegicus,Cricetulus migratorius,Gnathostomata,Cyclostomata,Homo sapiens,Escherichia coli,Capra hircus,Prunus domestica)
• Possible mechanisms of opioid receptor mediated influence of morphine on tumor growth (2011, NA)
• PI3K signaling in neural aging and disease (2011, NA)
• PI3K signaling in normal neural function and LTP induction (2011, NA)
• Metabolic pathways of fatty acid (FA) and triacylglycerol (TAG) synthesis, and mechanisms by which lipid intermediates affect hepatic insulin sensitivity (2011, NA)
• JAK/STAT3 signaling pathway transmits information from cytokine/chemical signals outside the cell, through the cell membrane, and into the gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell (2011, Homo sapiens,Mus musculus)
• Phosphatidylinositol 3-kinase (PI3K) signaling cascade (2011, NA)
• IR and IGF-IR signaling (2011, NA)
• Working hypothesis of the intracellular signal pathway of enocytoid lysis in response to PGs in Spodoptera exigua (2011, NA)
• Endocrine signaling pathways affecting longevity (2011, NA)
• Molecular pathway of activation of autophagy (2011, NA)
• Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy (2011, NA)
• Expression Level Drives the Pattern of Selective Constraints along the Insulin/Tor Signal Transduction Pathway in Caenorhabditis (2011, NA)
• Tax targets the NFKB pathway (2011, Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,Mouse mammary tumor virus,Human T-cell leukemia virus type I,Human T-lymphotropic virus 2,Homo sapiens,Mus musculus,Isodon rubescens,NA)
• Fibronectin - c-Myc network (2011, Gallus gallus,Danio rerio,Xenopus laevis,Ambystoma mexicanum,Notophthalmus viridescens,Homo sapiens,Mus musculus,Diaporthe sclerotioides,unidentified)
• Repeated Small Perturbation Approach Reveals Transcriptomic Steady States (2011, Escherichia coli,halophilic archaeon,Halobacterium salinarum NRC-1,Dipturus trachyderma,Petrocephalus catostoma,Homo sapiens,Saccharomyces cerevisiae,Influenza A virus,Mustela putorius furo)
• Dual role for the SIN in MOR pathway regulation (2011, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Drosophila melanogaster)
• Insulin-Like Growth Factor-1 Receptor Is Regulated by microRNA-133 during Skeletal Myogenesis (2011, Bos taurus,Canis lupus familiaris,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,vectors)
• Emerging pharmacological strategies for CSCs targeting include self-renewal pathway antagonists and chemoresistance-reverting agents (2011, NA)
• Central regulation of leptin signaling, autonomic innervation of the adipocyte and Beta-cell, and the starvation response (2011, Rattus norvegicus,Cricetulus griseus,Homo sapiens)
• UV lesions and their repair (2011, NA)
• ERK/MAPK Is Essential for Endogenous Neuroprotection in SCN2.2 Cells (2011, NA)
• Examples of the signaling role of Cdc42 in selective tissue cell types (2011, NA)
• Computational and Experimental Study of the Regulatory Mechanisms of the Complement System (2011, Pseudomonas aeruginosa,Streptococcus pyogenes,Neisseria gonorrhoeae,Moraxella catarrhalis,Escherichia coli K1,Moraxella catarrhalis BC1,Saccharomyces cerevisiae,Oryctolagus cuniculus,Capra hircus,Diaporthe sclerotioides,Ovis aries,Candida albicans,Homo sapiens,Mus musculus,Drosophila melanogaster,prion)
• c-MET signaling adaptors and mediators (2011, NA)
• Differential regulation of genes in the IL-10 pathway in neonates and school-age children with septic shock versus age-matched controls (2011, NA)
• General pathway for phosphatidylinositide (PI) synthesis (2011, Drosophila melanogaster,Plasmodium falciparum,Trypanosoma cruzi,Trypanosoma brucei,Leishmania major,Anopheles gambiae,Entamoeba histolytica,Plasmodium vivax,Giardia intestinalis,Leishmania infantum,Ciona intestinalis,Branchiostoma lanceolatum,Trichomonas vaginalis,Branchiostoma floridae,Leishmania sp.,Trypanosoma sp.,Plasmodium sp.,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Canis lupus familiaris,Diaporthe sclerotioides,Homo sapiens,vectors,Corynebacterium phage gamma,Vertebrata,NA)
• Prostaglandin E2 acts as a gliotransmitter to stimulate GnRH neuron electrical activity (2011, NA)
• Prostaglandin E2 (PGE2) biosynthesis and signaling (2011, NA)
• c-MET transactivation (2011, NA)
• Sensing the HP-PRRSV infection by host cell (2011, NA)
• Activation of the Pi3K/Tor pathway by insulin and glutamate (2011, Homo sapiens,Mus musculus)
• Interaction between MAPK signaling pathway–related genes and miRNAs (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Differential regulation of genes in the antigen presentation pathway in neonates and school-age children with septic shock versus age-matched controls (2011, NA)
• Intracellular signalling during inflammation-induced osteoclastogenesis (2011, NA)
• Cell cycle, cellular growth and proliferation pathways detected by ingenuity pathways analysis (2011, NA)
• Resistance to RAF inhibitors in melanoma (2011, NA)
• Wnt/Beta-catenin signaling pathway generated by Ingenuity Pathway Analysis (IPA) (2011, NA)
• Multiple substrates of the PI 3-kinase/Akt pathway mediate growth and metabolic signals in skeletal muscle (2011, NA)
• The c-MET (mesenchymal–epithelial transition factor) dependent signaling pathway (2011, Homo sapiens)
• S1P receptor signaling (2011, NA)
• Various signaling pathways modulated by the primary cilium (2011, Homo sapiens,Mus musculus,Caenorhabditis elegans,NA)
• APPL1-regulated TAK1-MKK3-p38 MAPK pathway in response to Ad stimulation (2011, NA)
• Expression profiles of the RNAs encoding enzymes in the alpha-linolenic acid pathway (2011, NA)
• Top Canonical pathways regulated (2011, NA)
• PAR2signaling from apical and basolateral surfaces (2011, Mus musculus,Homo sapiens)
• Summary of CD83 pathway regulating display of MHC II and CD86 on DCs (2011, Human alphaherpesvirus 1,Human betaherpesvirus 5,Adeno-associated virus,Human gammaherpesvirus 8,Murid betaherpesvirus 1,Orf virus,Ovine gammaherpesvirus 2,Mus musculus,Rattus norvegicus,Escherichia coli,Capra hircus,Equus caballus,Escherichia coli MA6,Homo sapiens,Armoracia rusticana,Discosoma sp.,NA)
• Intracellular transport pathway of Shiga toxin (2011, NA)
• FBPA clustering on gene expression in the bystander response (2011, NA)
• FBPA clustering on gene expression after direct irradiation (2011, NA)
• IPA pathway graphical representation of Aryl Hydrocarbon Receptor Signaling (2011, Human papillomavirus,Human papillomavirus type 16,Human papillomavirus type 6,Homo sapiens,Mus musculus)
• Discrete Dynamics Model for the Speract-Activated Ca2+ Signaling Network Relevant to Sperm Motility (2011, NA)
• Combining Genome-Wide Association Mapping and Transcriptional Networks to Identify Novel Genes Controlling Glucosinolates in Arabidopsis thaliana (2011, NA)
• Rationale for dual treatment targeting the IGF-1R signaling pathway in RMS (2011, Homo sapiens,Mus musculus,Gallus gallus)
• Wnt signaling pathway (2011, Homo sapiens,Mus musculus,Corynephage beta)
• NFKB signaling pathways (2011, NA)
• Putative PGC-1-mediated mechanism of cancer-induced skeletal muscle wasting (2011, NA)
• NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways (2011, NA)
• Association of mitochondrial peptidyl Cys with functional networks according to reduction and oxidation of Cys residues (2011, NA)
• Association of nuclear peptidyl Cys with functional networks according to reduction and oxidation of Cys residues (2011, NA)
• Association of cytoplasmic peptidyl Cys with functional networks according to reduction and oxidation of Cys residues (2011, NA)
• Post-transcriptional control of mammalian clock genes (2011, NA)
• Genes regulated by Survivin in ITD-Flt3+KSL cells and deregulated in LSC are mapped on functional signaling network associated with epidermal growth factor receptor signaling pathway (2011, NA)
• PI3K in immune system (2011, NA)
• Citrate metabolism in L (2011, NA)
• Crosstalk between the canonical and non-canonical transforming growth factor-beta1 (TGFB1) and myostatin pathways (2011, NA)
• Activation of IKK pathway (2011, NA)
• General and organelle-specific stress response pathways influenced by the ageing process (2011, NA)
• Signaling network connecting Rheb and AMPK (2011, NA)
• Three arms of the unfolded protein response stress-responsive signaling pathway (2011, Homo sapiens)
• Substance P Induces Rapid and Transient Membrane Blebbing in U373MG Cells in a p21-Activated Kinase-Dependent Manner (2011, NA)
• Molecular Basis for Vulnerability to Mitochondrial and Oxidative Stress in a Neuroendocrine CRI-G1 Cell Line (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Armoracia rusticana)
• Functional role of PP2C enzymes in yeast MAPK pathway regulation and organelle inheritance (2011, NA)
• Functions of p12 and p8 (2011, NA)
• Survival pathways controlled by Tax (2011, NA)
• FRAM Is Characterized by Increased Signaling of the BRAF/MEK/ERK Pathway(A) IPA analysis led to the generation of a gene-interaction network of genes differentially expressed in patients (2011, Homo sapiens)
• Influence of Stochastic Gene Expression on the Cell Survival Rheostat after Traumatic Brain Injury (2011, NA)
• TGFB superfamily signaling pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Candida dubliniensis)
• Interplay between HTLV-1 and the type-I interferon (IFN-I) induction pathway (2011, NA)
• Major pathways affected in NMSC (2011, NA)
• Working model of relaxin sustained-vasodilatory response (2011, Homo sapiens,Rattus norvegicus)
• Modifications of chromatin structure in response to enriched environmental stimulation or injury in the mature CNS (2011, Homo sapiens,Mus musculus,Rattus norvegicus,Cavia porcellus,Saimiri sciureus,Aotus trivirgatus,Felis catus,Procyon lotor,Diaporthe sclerotioides,Epalzeorhynchos kalopterus)
• Adenosine/L-arginine/nitric oxide (ALANO) signalling pathway in gestational diabetes mellitus (2011, NA)
• Canonical TGFB signaling within distinct cell types located in tumor microenvironments (2011, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Alteration of the IFN-I signaling pathway by HTLV-1 (2011, NA)
• mTOR signaling pathway (2011, NA)
• Cell surface and endosomal recognition of viruses by Toll-like receptors (TLRs) (2011, NA)
• ISC lineages of mammalian intestine and Drosophila midgut, and the common pathways that control them (2011, Drosophila melanogaster,Homo sapiens)
• c-Myc regulates the rate limiting steps at the entry into glycolysis (2011, Homo sapiens,Rattus norvegicus)
• Case study of the discovered phosphorylation networks associated with insulin signaling pathway (2011, Arabidopsis thaliana,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Characterization of the MDSC Proteome Associated with Metastatic Murine Mammary Tumors Using Label-Free Mass Spectrometry and Shotgun Proteomics (2011, NA)
• S1P receptor subtype-specific heterotrimeric G protein coupling and intracellular signaling mechanisms (2011, Homo sapiens)
• Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway (2011, Homo sapiens)
• The molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling (2011, NA)
• Inhibition of prostate cancer cell proliferation through statin use, and its impact on the HMG-CoA pathway (2011, NA)
• TRPM channels in insulin secretion (2011, NA)
• The molecular pathway by which FGF21 induces GLUT1 expression through the activation of SRE/ETS signaling cascade in adipocyte (2011, Mus musculus,Cervus elaphus,Homo sapiens)
• Models for how Wnt signaling maintains pluripotency in ES cells (2011, NA)
• Proposed signaling pathways modulated by Alpha-TEA and TAM in TAMR cells (2011, NA)
• Involvement of miR-221/222 as downstream effectors of the EGFR-RAS-RAF-MEK pathway in progression of metastatic transformation of breast cancer tumors (2011, Homo sapiens,Mus musculus)
• Network representation of altered cellular functions during colonization of the mouse colon by A (2011, Akkermansia muciniphila,Homo sapiens)
• NCC specification and emigration during trunk elongation (2011, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Signaling pathways associated with cardiac hypertrophy (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Cerobasis alpha)
• Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT1) Receptor Blockade (2011, NA)
• Pathways involved in the pathogenesis of cardiac fibrosis in the senescent heart (2011, NA)
• The canonical vertebrate Wnt signaling pathway (2011, NA)
• Proposed model for a common symbiotic signaling pathway between actinorhizal plants and legumes (2011, Casuarina glauca,Alnus glutinosa,Actinomycetia bacterium)
• Different pathways of myostatin signalling (2011, NA)
• Functional role of skeletal muscle-derived neurotrophic factors after exercise (2011, Gallus gallus,Xenopus laevis,Merluccius merluccius,Mus musculus,Rattus norvegicus,Homo sapiens)
• Insulin signaling pathway in adipocytes: showing potential sites of rhoifolin and cosmosiin interactions (2011, Armoracia rusticana,Ginkgo biloba,Trigonella foenum-graecum,Cynodon dactylon,Citrus maxima,Toona sinensis,Canna indica,Lawsonia inermis,Lagerstroemia speciosa,Citrus depressa,Argania spinosa,Ligustrum robustum,Erica cinerea,Cephalotaxus sinensis,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta)
• Signalling pathway of type III interferons (IFNs) compared with type II and type I IFNs (2011, unidentified influenza virus,Hepatitis C virus genotype 2,Homo sapiens,Diaporthe sclerotioides,NA)
• Proposed lithium’s neuroprotective effects against cerebral ischemia (2011, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Cerobasis alpha,Homo sapiens,Gallus gallus)
• The crosstalk between the NOTCH and AKT pathways at the molecular and cellular levels (2011, NA)
• MAPK signaling pathway (2011, NA)
• Suppression of anaerobic metabolism by p53 is mediated through multiple pathways (2011, Homo sapiens,Mus musculus)
• Regulation of mTOR pathway by Sestrins (2011, NA)
• Regulation of the mTOR signaling pathway by insulin and growth factors (2011, NA)
• Differential expression of mRNA and proteins encoding factors in the Notch signaling pathway (2011, NA)
• Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway (2011, Rattus norvegicus,Homo sapiens)
• Expression of some genes related to the cell cycle and apoptosis were significantly changed after LM23 knockdown, as shown by microarray analysis (2011, NA)
• Schematic summary of a signaling pathway underlying IL-1Beta-induced dedifferentiation of primary cultured articular chondrocytes (2011, Oryctolagus cuniculus,Homo sapiens)
• Main steps in the trafficking of the signaling protein Hh (2011, NA)
• Adhesion of sickle red blood cells to the endothelium and cell activation (2011, Homo sapiens,Mus musculus,Candida dubliniensis)
• Network of core pathways that mediate commitment of cells to the division cycle (2011, NA)
• Mammals have two distinct but ultimately converging pathways to apoptosis (2011, Homo sapiens,Mus musculus)
• The molecular players involved in angiogenesis signalling mediated by the interaction of VEGF-A with VEGFR-2 (2011, Orf virus,Orf virus strain NZ2,Orf virus NZ7,Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Gallus gallus,Corynebacterium phage gamma)
• Dys–Syn–nNOS pathway and miRNAs coordinate the muscle differentiation program (2011, Homo sapiens,Mus musculus,Drosophila melanogaster)
• EP4 signaling in keratinocytes (2011, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Moolgarda engeli)
• Hypothetical roles for LAB-dependent positive signaling (2011, NA)
• Gene Expression Analysis in the Thalamus and Cerebrum of Horses Experimentally Infected with West Nile Virus (2011, Human immunodeficiency virus 1,Dengue virus,West Nile virus,Yellow fever virus,Dengue virus type 2,Bos taurus,Canis lupus familiaris,Equus caballus,Mus musculus,Cricetus cricetus,Homo sapiens,Drosophila melanogaster,Sequoia sempervirens)
• Protein interaction network of highly connected proteins associated with the cardiorenal syndrome (2011, Homo sapiens,Rattus norvegicus)
• Biosynthetic pathway of GSL and the CIRES procedure (2011, NA)
• Epidermal growth factor and aging: A signaling molecule reveals a new eye opening function (2011, NA)
• Inhibition of the KAI1 cancer metastasis suppressor pathway in African-American patients (2011, Nicotiana tabacum)
• The interactions between Rho/Rho-kinase signaling and bone morphogenetic protein (BMP)/transforming growth factor (TGF)B signaling (2011, NA)
• Differentially expressed genes in the toll-like receptor signaling pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (2011, Mus musculus,Homo sapiens)
• Striatal-enriched protein tyrosine phosphatase and Alzheimer’s disease (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of STEP phosphorylation (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Apoptotic pathway in cardiac myocytes (2011, NA)
• EP1 signaling in keratinocytes (2011, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Moolgarda engeli)
• Divergent BMP signaling pathways controlling transcriptional and cytoskeletal responses (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Armoracia rusticana,Staphylococcus hominis)
• GProX Pathway Analysis of the Cellular Response to EGF Stimulation (2011, NA)
• Single-run analysis of the yeast proteome by LC MS/MS (2011, NA)
• NOD2, an Intracellular Innate Immune Sensor Involved in Host Defense and Crohn's Disease (2011, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Listeria monocytogenes,Bacillus anthracis,Borreliella burgdorferi,Helicobacter hepaticus,Homo sapiens,Mus musculus,Respiratory syncytial virus)
• Summary of the UPR pathway in rotavirus infected cells (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Matthiola incana,Saccharolobus solfataricus,Simian rotavirus A strain RRV)
• Framework of integrated pathway simulation model of thrombin-, histamine-, and VEGF-mediated MLC activation (2011, NA)
• Summary diagram of the proposed ADM signaling pathway in retina (2011, NA)
• Altered Insulin Receptor Signalling and Beta-Cell Cycle Dynamics in Type 2 Diabetes Mellitus (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Working model for the Grb14-mediated inhibition of PTP1B activity (2011, NA)
• Simplified TOR signaling network with known Arabidopsis homologs in Italic writing (2011, NA)
• Podocyte foot process effacement by receptor-operated calcium channel signaling (2011, Rattus norvegicus,Homo sapiens)
• Beta-adrenergic signaling pathways (2011, NA)
• PHD2/3 and miR-155 negative-feedback loops are part of the regulatory network of HIF-1A in prolonged hypoxia (2011, NA)
• Metabolic networks of Corynebacterim glutamicum (a) and Brassica napus (b) corresponding to the experimental fluxes measured by and respectively (2011, NA)
• Perturbed TGFB/Smad and mitogen-activated protein kinase signalling pathways in Dupuytren's fibroblasts (2011, NA)
• Molecular mechanisms mediating the regulatory effects of hypoxia (2011, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified,Abelson murine leukemia virus)
• TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding (2011, Mus musculus,Rattus norvegicus,Escherichia coli,Oryctolagus cuniculus,Canis lupus familiaris,Staphylococcus aureus,Cavia porcellus,Felis catus,Mycolicibacterium smegmatis,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,vectors)
• Simulating EGFR-ERK Signaling Control by Scaffold Proteins KSR and MP1 Reveals Differential Ligand-Sensitivity Co-Regulated by Cbl-CIN85 and Endophilin (2011, NA)
• mTOR signalling pathway (2011, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• IL-1 signaling in the tumor microenvironment (2011, NA)
• Simplified model of autophagy (2011, NA)
• MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus (2011, NA)
• Pro-inflammatory pathway induction by cAMP/PKA signaling in BSC-derived lesions (2011, NA)
• Schematic overview of IDO induction by H (2011, NA)
• FcERI signaling events in WT, NTAL−/−, and LAT−/− cells (2011, NA)
• Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis (2011, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Gallus gallus)
• Cell death induced by Rb and TSC2 inactivation (2011, NA)
• B-Raf Status of Tumor Cells May Be a Significant Determinant of Both Antitumor and Anti-Angiogenic Effects of Pazopanib in Xenograft Tumor Models (2011, NA)
• Canonical signaling pathways activated by the EP receptors for PGE2 (2011, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Moolgarda engeli)
• TLR ligands and signalling (2011, Saccharomyces cerevisiae,Candida albicans,Cryptococcus neoformans,Histoplasma capsulatum,Paracoccidioides brasiliensis,Trichophyton rubrum,Candida albicans 11C,Cardamine californica,Influenza A virus,unidentified influenza virus,ssRNA viruses,Variola virus,dsRNA viruses,Mycobacterium tuberculosis,Streptococcus pyogenes,Serratia marcescens,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster)
• Schematic overview of the steroidogenic pathway (2011, Homo sapiens)
• Axon viability depends on coordinated endocytic trafficking and signaling (2011, NA)
• PARP function in base excision repair and consequences of PARP inhibition (2011, Homo sapiens)
• Phosphorylation pathways adapted from KEGG (50)(51) (2011, NA)
• Potential regulatory mechanism of the identified gene switches for breast cancer (2011, NA)
• Evolutionary reconstruction of the ancestral TOR signaling pathway based on the evolutionary reconstruction of the AGC kinase ancestral genes of S6K, RSK1, PKB and SGK1 (2011, NA)
• Evolution of the mTOR pathway (2011, NA)
• Genome Sequence of a Mesophilic Hydrogenotrophic Methanogen Methanocella paludicola, the First Cultivated Representative of the Order Methanocellales (2011, NA)
• A Review of an Unfavorable Subset of Breast Cancer: Estrogen Receptor Positive Progesterone Receptor Negative (2011, Homo sapiens)
• Expression and Functional Roles of Angiopoietin-2 in Skeletal Muscles (2011, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Gallus gallus,Armoracia rusticana,unidentified shuttle vector)
• The transcriptional regulation of bim expression by prosurvival signalling pathways in sympathetic neurons (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• PI3K/AKT/mTOR signaling network regulates cell survival, proliferation, migration, metabolism, and apoptosis, integrating the growth factor signaling pathway, nutrient status, and other oncogenic pathways (2011, NA)
• Schematics of the Hippo pathway in flies and mice (2011, NA)
• Proposed unified model of the pathophysiology of CD representing the different known and suggested mechanisms involved in that disease (2011, NA)
• HCG/MET signaling pathway (2011, NA)
• Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA (2011, NA)
• Direct Sensing of Endothelial Oxidants by Vascular Endothelial Growth Factor Receptor-2 and c-Src (2011, NA)
• Expanded representation of the KEGG pathway "colorectal cancer" (2011, NA)
• TNF related apoptosis-inducing ligand and its receptors in ocular tumors (2011, NA)
• Top IPA generated network (2011, Mycobacterium tuberculosis,Listeria monocytogenes,Lactococcus lactis,Mycobacterium tuberculosis H37Rv,Lacticaseibacillus paracasei,Lactobacillus delbrueckii subsp. lactis,Listeria innocua,Listeria monocytogenes EGD-e,Listeria monocytogenes EGD,Homo sapiens,Mus musculus,Gallirallus australis)
• Genetic model for nuage assembly and piRNA pathway genes in mice (2011, Mus musculus,Caenorhabditis elegans,Homo sapiens)
• Signaling cascade of class I and IIa HDACs in the development of cardiac hypertrophy (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Summary of fatty acid and glucose metabolism (2011, NA)
• Pathway assignment of the important genes based on KEGG (2011, NA)
• Redox-Induced Src Kinase and Caveolin-1 Signaling in TGFB1-Initiated SMAD2/3 Activation and PAI-1 Expression (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus)
• Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes (2011, NA)
• Proposed signal transduction pathways in nodose ganglia following receptor activation with leptin and cholecystokinin-8 (CCK-8) (2011, NA)
• Endothelial adaptive response to moderate hypothermia (25°C/72 h) (2011, NA)
• Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G2/M-enriched MCF-7 cell cultures (2011, NA)
• Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in S-enriched MCF-7 cell cultures (2011, NA)
• Putative signal transduction pathways regulating fruiting body development in C (2011, Cordyceps militaris,Saccharomyces cerevisiae,Oryza sativa,Glycine max,Solanum tuberosum,Triticum aestivum,Candida albicans,Aspergillus fumigatus,Magnoliopsida,Agaricus bisporus,Aspergillus nidulans,Botrytis cinerea,Cryptococcus neoformans,Pyrus communis,Neurospora crassa,Aspergillus flavus,Fusarium oxysporum,Aspergillus oryzae,Pyricularia oryzae,Fusarium graminearum,Pyricularia grisea,Trichoderma reesei,Fusarium verticillioides,Sclerotinia sclerotiorum,Fusarium fujikuroi,Ophiocordyceps sinensis,Metarhizium anisopliae,Aspergillus clavatus,Schizophyllum commune,Monascus purpureus,Fusarium sporotrichioides,Epichloe festucae,Trichophyton mentagrophytes,Candida albicans 22C,Metarhizium acridum,Bipolaris zeicola,Fusarium equiseti,Metarhizium sp. RMK-2011b,Tolypocladium inflatum,Cordyceps militaris CM01,Fagus crenata,Bombyx mori,Antheraea pernyi,Homo sapiens,unidentified influenza virus,uncultured actinomycete,NA)
• Cordycepin analogues and the C (2011, Cordyceps militaris,Saccharomyces cerevisiae,Oryza sativa,Glycine max,Solanum tuberosum,Triticum aestivum,Candida albicans,Aspergillus fumigatus,Magnoliopsida,Agaricus bisporus,Aspergillus nidulans,Botrytis cinerea,Cryptococcus neoformans,Pyrus communis,Neurospora crassa,Aspergillus flavus,Fusarium oxysporum,Aspergillus oryzae,Pyricularia oryzae,Fusarium graminearum,Pyricularia grisea,Trichoderma reesei,Fusarium verticillioides,Sclerotinia sclerotiorum,Fusarium fujikuroi,Ophiocordyceps sinensis,Metarhizium anisopliae,Aspergillus clavatus,Schizophyllum commune,Monascus purpureus,Fusarium sporotrichioides,Epichloe festucae,Trichophyton mentagrophytes,Candida albicans 22C,Metarhizium acridum,Bipolaris zeicola,Fusarium equiseti,Metarhizium sp. RMK-2011b,Tolypocladium inflatum,Cordyceps militaris CM01,Fagus crenata,Bombyx mori,Antheraea pernyi,Homo sapiens,unidentified influenza virus,uncultured actinomycete,NA)
• Ingenuity Pathway Analysis (IPA) on genes modulated by BaP in G1-enriched MCF7 cell cultures (2011, NA)
• CSR pathways for primary non-HCC hepatocytes and HCC (Huh7) cell types (2011, NA)
• IsomiRs and miRNAs target similar biological pathways (2011, Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Sus scrofa,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Danio rerio,NA)
• Oncogenic EGFR signaling activates an mTORC2-NFKB pathway that promotes chemotherapy resistance (2011, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,clinical samples)
• Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics (2011, NA)
• Schematic overview of proposed G protein-coupled oestrogen receptor 1 (GPER1) signalling (2011, NA)
• Signal pathway activation by different surface PRRs (2011, NA)
• Multiple factors and pathways affect insulin-like growth factor 1 (IGF1)-Akt signaling (2011, NA)
• The insulin-like growth factor 1 (IGF1)-Akt pathway controls muscle growth also via glycogen synthase kinase B (GSK3B) (2011, NA)
• Inhibition of myostatin (MSTN) and activin signalling by the soluble activin type IIB receptor (ActRIB) (2011, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus)
• The differentiation hierarchy within the mammary epithelium and potential relationships with breast cancer subtypes (2011, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• AKT signalling in the heart (2011, NA)
• Putative crosstalk between D1and TrkB receptors in striatal direct pathway neurons controlling PPD mRNA expression (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Prunus avium)
• Ingenuity pathway analysis of PKCAlpha-CT regulated, MEF2-targetted cardiac mRNAs (2011, NA)
• Regulation of cell migration by signaling endosomes (2011, NA)
• Gap junctional communication between the oocyte and the surrounding somatic cells regulates oocyte meiotic maturation (2011, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Schematic representation showing proposed role of TMPRSS6 regulation by the BMP6-SMAD signaling pathway and iron via ID1 (2011, Homo sapiens,Mus musculus)
• Broad overview of the genetic architecture of inflammatory bowel disease giving examples of confirmed and candidate genes implicated in each pathway (2011, NA)
• External stimuli (hyperglycemia, inflammation resulting from trauma, infection, or other injury) activate certain cells (e.g., endothelial cells, osteoblasts) to release RANKL (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Diaporthe sclerotioides)
• Simplified schematic presentation of the transcriptional hierarchy of essential factors and signaling pathways during endocrine specification of the pancreatic endoderm (2011, Homo sapiens)
• Cause and metabolic consequences of fatty liver (2011, NA)
• An E-cadherin–mediated Hippo signaling pathway (2011, NA)
• ER Ca2+ in synaptic plasticity (2011, NA)
• TLR4 signaling cascade and evidence for modulation by neuropathic pain and opioids (2011, NA)
• IGF-IR downstream signal transduction (2011, Mus musculus,Rattus norvegicus,Marmota monax,Hepatitis B virus,Betapolyomavirus macacae,Homo sapiens,Danio rerio,Diaporthe sclerotioides,NA)
• Ca 2+ signal cross talk between Epac and GBG (2011, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• Genes identified in the TGF beta pathway (2011, NA)
• Integrated Expression Profiling and Genome-Wide Analysis of ChREBP Targets Reveals the Dual Role for ChREBP in Glucose-Regulated Gene Expression (2011, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,vectors,Escherichia coli K-12)
• 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation (2011, NA)
• 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation (2011, NA)
• Altered striatal signaling pathways in HD (2011, Homo sapiens)
• Stat3 interactions in glioma biology (2011, Homo sapiens)
• Toll-like receptor (TLR) and type I interferon (IFN) signaling pathways (2011, Homo sapiens)
• Schematic summary of striatal gene expression changes in response to SNCA overexpression (2011, NA)
• Roles of phosphodiesterases (PDEs) in the control of basal ganglia–thalamocortical circuitry (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis)
• Schematic model for the activation of NFKB signaling pathways (2011, NA)
• Deciphering the role of Nuclear FactorKB in cellular senescence (2011, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• D1 receptor signaling cascades in striatonigral/direct pathway neurons (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis)
• Proteomic Biomarkers for Acute Interstitial Lung Disease in Gefitinib-Treated Japanese Lung Cancer Patients (2011, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Tequatrovirus T4)
• Variation in the suppressive abilities of Wnt antagonists with respect to canonical and non-canonical Wnt signaling pathways (2011, Homo sapiens)
• Main NFKB-activating pathways (2011, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Hyphal Development in Candida albicans Requires Two Temporally Linked Changes in Promoter Chromatin for Initiation and Maintenance (2011, NA)
• Schematic diagram of H1N1-induced signaling and inflammatory genes expression (2011, NA)
• Common pathway of anoikis induction (2011, NA)
• Testosterone signaling pathways (2011, NA)
• Summary of Kit/Kitl signaling during spermatogenesis (2011, NA)
• Autophagy mediates degradation of NFKB signaling components (2011, NA)
• p130Cas and p140Cap signalling involved in migration and invasion (2011, NA)
• Deciphering the role of Nuclear FactorKB in cellular senescence (2011, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Signaling pathways leading to 3D invasion of ErbB2 transformed MCF10 cells over-expressing p130Cas (2011, NA)
• B1/Fak/Src integrin signaling, cell survival, and suppression of anoikis (2011, NA)
• Intrinsic pathway of apoptosis (2011, NA)
• Model showing elevated calcium and/or phosphate up-regulate HGF secretion and c-Met activation in conjunction with activation of the PI3K/Akt signalling pathway, leading to SMC mineralisation, which can be inhibited by AdNK4 treatment (2011, Homo sapiens,Oryctolagus cuniculus)
• Simplified schematic of macroautophagy in mammals (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Adenoviridae,Vasconcellea candicans,Sindbis virus,Homo sapiens,Drosophila melanogaster)
• Targets and therapies for B-cell non-Hodgkin's lymphoma (B-NHL) within the context of the 10 hallmarks of cancer and overlapping oncogenic signaling pathways (2011, NA)
• Deciphering the role of Nuclear FactorKB in cellular senescence (2011, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Simplified pathway and drug interactions (2011, Homo sapiens,Human gammaherpesvirus 8)
• Insights into the Molecular Mechanisms of the Anti-Atherogenic Actions of Flavonoids in Normal and Obese Mice (2011, NA)
• Signaling pathway for epidermal growth factor receptor (EGFR) (2011, NA)
• Signal Transduction pathways downstream of activated HER family of receptors (2011, Homo sapiens)
• Epithelial cell recognition of C (2011, NA)
• Signal pathway activation by the main TLR and CLR receptors that detect Candida (2011, NA)
• The anthocyanin biosynthetic pathway (adapted from ) (2011, Passiflora edulis,Homo sapiens)
• The inhibitory effects of THL and its active fraction EAS5 on the oncogenic signaling pathways in NB4 cells (2011, NA)
• Schematic diagram illustrating the signaling pathways involved in 8-PK's inhibition of RANTES production in H1N1-infected A549 cells (2011, Hepatitis B virus,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Coxsackievirus B3,Influenza A virus H3N2,Influenza A virus H1N1,Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Sophora flavescens)
• CAFET Algorithm Reveals Wnt/PCP Signature in Lung Squamous Cell Carcinoma (2011, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• TLR-dependent and JAK/STAT-dependent signaling pathways in microglia (2011, NA)
• Pathway of miR-148a induction of apoptosis (2011, NA)
• NFKB signaling pathways (2011, NA)
• Roles of FGF signaling in stem cell self-renewal, senescence and aging (2011, NA)
• BMP signaling in motor neurons (2011, Gallus gallus,Danio rerio,Xenopus laevis,Merluccius merluccius,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus)
• HSC cell cycle entry is regulated by a complex network of cell-intrinsic and cell-extrinsic factors (2011, NA)
• Integrative computational biology for cancer research (2011, Saccharomyces cerevisiae,Oryza sativa,Sorghum bicolor,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Autophagy regulation (2011, NA)
• Proposed mechanisms of HK-mediated Ca2+signaling in endothelial cells (2011, NA)
• Autophagy pathway and relationship to mTOR signaling (2011, NA)
• Model showing the various molecular components associated with the store-operated calcium entry pathway (2011, NA)
• Regulation of CYP1A1 by capsaicin in Hepa-1c1c7 cells (2011, NA)
• Hypothesis of insulin signaling pathways associated with the regulation of CIDEA and CIDEC expression in human adipocytes (2011, Homo sapiens)
• Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways (2011, NA)
• Balancing Calcium Signals through TRPC5 and TRPC6 in Podocytes (2011, NA)
• Zn and Zn transporters are indispensable for FcERI-mediated mast cell activation (2011, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio,Equus caballus,Aspergillus niger,NA)
• Models of Loco signaling pathway with small GTPases (2011, Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Homo sapiens)
• Identification and Analysis of Signaling Networks Potentially Involved in Breast Carcinoma Metastasis to the Brain (2011, NA)
• Targeting of eEF1A1 is a novel mechanism in TGFB signaling (2011, NA)
• IL-1RI signaling (2011, NA)
• DRD2/GSK3B/DISC1 pathway modified from Beaulieu et al (2011, Homo sapiens,Mus musculus,Cannabis sativa)
• The dual ERK1-dependent impact on regulated processing and transcription of PrPc (2011, Mus musculus,prion,Homo sapiens)
• Diagram summarizing the effects produced by L-DOPA and haloperidol on cAMP signaling in the striatal MSNs of the direct and indirect pathway (2011, NA)
• Qu on cell cycle (2011, Glycine max,Panax ginseng,Vitis vinifera,Arachis hypogaea,Curcuma longa,Camellia sinensis,Brassica oleracea,Allium cepa,Theobroma cacao,Zingiber officinale,Punica granatum,Vaccinium myrtillus,Pteridium aquilinum,Ticanto crista,Mus musculus,Rattus norvegicus,Homo sapiens,Venustaconcha ellipsiformis)
• Simplified overview of the fatty acid biosynthesis and some of the competing pathways in cyanobacteria (adapted from Liu et al (2011, Escherichia coli,Synechocystis sp. PCC 6803,Synechocystis sp.,Zymomonas mobilis,Synechococcus elongatus PCC 6301,Synechococcus elongatus PCC 7942 FACHB-805,Nostoc sp. PCC 7120 FACHB-418,Arthrospira platensis,Synechococcus sp. PCC 7002,Acinetobacter calcoaceticus,Synechococcus elongatus,Nostoc sp.,Synechococcus sp.,Crocosphaera subtropica ATCC 51142,Komagataeibacter xylinus,Anabaena sp.,Nostoc commune,Limnospira maxima,Trichormus variabilis,Anabaena cylindrica,Phormidium sp.,Nostoc flagelliforme,Spirulina subsalsa,Nodularia sp. in cyanobacteria,Thermostichus vulcanus,Synechococcus sp. 7002,Lyngbya semiplena,Anabaena sp. CA ATCC 33047,Oscillatoria subbrevis,Nostoc paludosum,Crinalium epipsammum,Scytonematopsis crustacea,Oscillatoria salina,Phormidium corium,Gloeocapsopsis crepidinum,Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Glycine max,Lareunionomyces loeiensis,Embryophyta,Triticum aestivum,PX clade,Arachis hypogaea,Helianthus annuus,Saccharum officinarum,Sesamum indicum,Panicum virgatum,Auxenochlorella pyrenoidosa,Pueraria montana,Monoraphidium minutum,Bos taurus,Sus scrofa,Triportheus paranensis,Thalasseus maximus maximus,Homo sapiens)
• Working model for the role of USP4 in the negative regulation of TNFAlpha-induced TAK1 polyubiquitnation and NFKB activation (2011, NA)
• Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood (2011, Homo sapiens,Mus musculus,Ovis aries,Respiratory syncytial virus,Sequoia sempervirens,Chlamydia pneumoniae)
• Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood (2011, Homo sapiens,Mus musculus,Ovis aries,Respiratory syncytial virus,Sequoia sempervirens,Chlamydia pneumoniae)
• Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood (2011, Homo sapiens,Mus musculus,Ovis aries,Respiratory syncytial virus,Sequoia sempervirens,Chlamydia pneumoniae)
• ER stress-mediated induction of CAMP in human KC (2011, NA)
• “big picture” between DM2 and cancer (2011, NA)
• Schematic showing the proposed sites of RA action in lung development (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Distinct Peripheral Blood RNA Responses to Salmonella in Pigs Differing in Salmonella Shedding Levels: Intersection of IFNG, TLR and miRNA Pathways (2011, NA)
• Canonical and non-canonical NFKB signalling pathways (2011, NA)
• Signaling schematic representation: The postulated signaling pathway involved in this study (2011, Homo sapiens,Mus musculus,Equus caballus)
• Survival and proliferative effects of Dilong extract on RSC96 Schwann cell (2011, NA)
• Transcriptome Analysis of H2O2-Treated Wheat Seedlings Reveals a H2O2-Responsive Fatty Acid Desaturase Gene Participating in Powdery Mildew Resistance (2011, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Triticum aestivum,Hordeum vulgare,Olea europaea,Brachypodium distachyon,Triticum turgidum subsp. durum,Betula pendula,Blumeria graminis,Aegilops tauschii,Puccinia triticina,Puccinia striiformis f. sp. tritici,Blumeria graminis f. sp. tritici,Dasypyrum villosum,Fusarium pseudograminearum,Homo sapiens,Barley stripe mosaic virus)
• P53 pathway in development, cancer, and reprogramming (2011, NA)
• Coordinated regulation of p53, target of rapamycin (TOR), and insulin/insulin-like growth factor 1 (IGF-1) pathways (2011, Homo sapiens,Mus musculus)
• Regulation of metabolism by p53 in proliferating cells (2011, NA)
• Metabolic target genes of p53 (2011, NA)
• Lipopolysaccharide (LPS)-dependent and nuclear factor (NF)KB-mediated activation of proinflammatory cytokines (2011, NA)
• Platelet activation pathways and drug molecular targets (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Simplified scheme for TLR signaling in enterocytes (2011, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Lactiplantibacillus plantarum,Bacteroides fragilis,Lacticaseibacillus casei,Lactobacillus acidophilus,Lacticaseibacillus rhamnosus,Lacticaseibacillus rhamnosus GG,Lacticaseibacillus paracasei,Bifidobacterium animalis subsp. lactis,Ligilactobacillus salivarius,Lactiplantibacillus pentosus,Lactiplantibacillus plantarum WCFS1,Lactobacillus acidophilus NCFM,Lactobacillus johnsonii NCC 533,Lentilactobacillus kefiri,Lactobacillus acidophilus La-14,Human immunodeficiency virus 1,unidentified influenza virus,ssRNA viruses,dsRNA viruses,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,human gut metagenome)
• Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii (2011, Toxoplasma gondii,Homo sapiens)
• There are four different MAPK pathways in mammalian cells: extracellular signal-regulated kinase-1 and -2 (Erk1/2), c-Jun N-terminal kinase (JNK), p38MAPK, and extracellular signal-regulated kinase-5 (Erk5/BMK1) [, ] (2011, NA)
• Immunoglobulin E Receptor Signaling and Asthma (2011, Homo sapiens,Mus musculus)
• FcERI signaling pathway is negatively regulated by a number of cell surface and intracellular proteins that act at various points in the FcERI signaling network (2011, Homo sapiens,Mus musculus)
• PARP in DNA Repair, Induced Damage, and Tumor Cells (2011, NA)
• The Ras-MAPK and TGFB pathways (2011, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Liver from Campari tomato treatment (2011, Oryza sativa,Solanum lycopersicum,Olea europaea,Arachis hypogaea,Cucumis sativus,Solanum melongena,Origanum vulgare,Gallus gallus,Danio rerio,Triportheus paranensis,Mus musculus,Rattus norvegicus,Homo sapiens,Mustela putorius furo)
• The signaling pathway of EpCAM complex proteins in the regulation and enhancement of OSKM-mediated pluripotency reprogramming (2011, Mus musculus,Homo sapiens)
• Regulation of HIF-1A by the PI3K pathway (2011, NA)
• Regulation of HIF-1A by the MAPK pathway (2011, NA)
• Action of ErbB receptor (2011, NA)
• Significantly altered genes by PEITC from the current study are presented in yellow boxes, and the effects of PEITC that have already been reported in previous studies are presented in blue boxes (2011, NA)
• Apoptotic Process (2011, NA)
• Role of Dot1 in DNA damage checkpoint response and repair (2011, NA)
• Cooperation of the genes in the DNA repair cluster (2011, Saccharomyces cerevisiae,Symphonia globulifera,Homo sapiens,Mus musculus)
• Concerted regulation of the WNT-DVL-GSK3B signaling pathway in NAc by chronic social defeat stress (2011, Homo sapiens,Mus musculus,Gallus gallus,Lareunionomyces loeiensis,Equus asinus)
• Bhlhb5 and the Notch signaling pathway (2011, Gallus gallus,Homo sapiens)
• Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment (2011, NA)
• Cytonuclear signaling pathways in MSNs (2011, NA)
• Adenovirus elicits IFNAB production by a novel viral induction pathway (2011, Adenoviridae)
• Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy (2011, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Second messengers and membrane trafficking direct and organize growth cone steering (2011, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Xenopus laevis,Cricetus cricetus,Homo sapiens,Drosophila melanogaster,Corynebacterium phage gamma)
• Proposed model for the involvement of the different CK1 isoforms in the Wnt pathway (2011, NA)
• Model showing the role for Bmi1 in the DNA damage response pathway (2011, Homo sapiens)
• Mechanism for the DOR-Cys27 variant-induced alteration in APP processing (2011, NA)
• Schematic model of Nrf2 regulation by Keap1 (2011, NA)
• Basic metabolic pathways of E (2011, NA)
• Functional inactivation of merlin by two-step phosphorylation (2011, Homo sapiens,Chlorocebus aethiops)
• Proposed model of early pathologic events occurring in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 male mice defined by changes in gene expression (2011, NA)
• CCN2 Is Required for the TGFB Induced Activation of Smad1 - Erk1/2 Signaling Network (2011, NA)
• B2-Agonist signaling pathways (2011, NA)
• Tumour necrosis factor receptor 1 (TNFR1) and its signalling pathways (2011, Homo sapiens)
• Non-small cell lung cancer-specific EGF-induced EGFR-mediated signal transduction pathway model previously developed in Wang et al (2011, Homo sapiens)
• Proposed mechanisms mediating the effect of the (pro)renin receptor (PRR) in metanephric kidney development (2011, NA)
• Hypothetical pathways that lead to CARF-suppression induced apoptosis (2011, NA)
• Hypothetical representation of AR pathway regulation by IL-6 in prostate cancer cells (2011, NA)
• Proposed mechanism for negative regulation of IL-12p40 expression by hyperactivation of ERK1/2 in the presence of LPS, corticosterone, and MW (2011, Mus musculus,Homo sapiens)
• Immune system in Bombus terrestris (2011, NA)
• Postulated model for GRTH negative autocrine molecular mechanism of regulation of androgen synthesis in Leydig cells (2011, NA)
• NFKB signaling pathways (2011, NA)
• Cellular targets of the Tax viral oncoprotein (2011, NA)
• TIR and NFKB signaling pathways (2011, NA)
• Wolbachia-induced responses of specific cell types (2011, NA)
• Comparative Genomic Analysis of Drosophila melanogaster and Vector Mosquito Developmental Genes (2011, Drosophila melanogaster,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Tribolium castaneum,Acyrthosiphon pisum,Culex quinquefasciatus,Anopheles stephensi,Anopheles quadrimaculatus,Lucilia sericata,Schistocerca americana,Aedes vexans,Aphidoletes aphidimyza,Gallus gallus,Danio rerio,Phoenicopterus roseus,Homo sapiens,Dengue virus,Dengue virus type 2,Papio anubis,Ovis aries,Solanum melongena,NA)
• Example yeast network (2011, NA)
• Schematic diagram showing signaling pathway HMC05 action against TNF-Alpha-induced vascular inflammation (2011, NA)
• Molecular mechanism of autophagy with synthesis of cathepsin D (2011, NA)
• PMn mechanisms of stability and plasticity (2011, NA)
• Ras/Raf/mitogen-activated protein kinase pathway (2011, NA)
• Endothelial nitric oxide synthase-derived nitric oxide synthesis (2011, NA)
• Sublytic MAC activation in RPE-cells increases regulated VEGF secretion (2011, NA)
• Glutamatergic modulation of striatal NOS interneurons by cortical inputs (2011, NA)
• Working model of cervical infection by gonococci (2011, Neisseria gonorrhoeae,Homo sapiens)
• MAPK activation during L (2011, Mycobacterium tuberculosis,Helicobacter pylori,Listeria monocytogenes,Neisseria gonorrhoeae,Legionella pneumophila,Rickettsia rickettsii,Legionella pneumophila str. Lens,Dictyostelium discoideum,Acanthamoeba castellanii,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• IL-6 classical and trans-signaling pathway (2011, NA)
• NOD-like receptor (NLR) family and inflammasome (2011, NA)
• Toll-like receptor (TLR) signaling pathway (2011, NA)
• Cell signaling between rNSCs and hMSCs in coculture (2011, Homo sapiens,Rattus norvegicus)
• Ras trafficking routes among subcellular compartments (2011, NA)
• Crosstalk and feedback in ERK and PI3K signaling downstream of RAS (2011, Homo sapiens,Mus musculus)
• RAS signaling to the PI3K pathway (2011, Homo sapiens,Mus musculus)
• NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Armoracia rusticana,NA)
• Complement cascade, hemolyisis, and eculizumab (2011, Homo sapiens,Sus scrofa,Aeromonas hydrophila)
• RIG-I Mediates Innate Immune Response in Mouse Neurons Following Japanese Encephalitis Virus Infection (2011, Bos taurus,Equus caballus,West Nile virus,Japanese encephalitis virus,Homo sapiens,Mus musculus)
• Highly simplified summary of the pathways underlying the proangiogenic activity of nicotine in HRMECs (2011, NA)
• GenMAPP Diagram of Cell Cycle Pathway Genes Regulated by Luteolin in E2-Treated MCF-7 Cells (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Bos taurus)
• Molecular pathway by which miR-21 regulates HVSMC contraction (2011, Homo sapiens)
• Luteolin Effects on Estrogen Signaling Pathway (ESP) Genes (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Bos taurus)
• TPO signaling pathway (2011, NA)
• Inactivated Wnt pathway (2011, NA)
• Activated Wnt pathway (2011, NA)
• The mTOR-signalling pathway from growth factor receptor through mTOR (2011, Homo sapiens)
• An integrated network of the significant KEGG pathways with their temporal perturbation patterns (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed mechanism for the regulation of opioid receptor functional competence by activation of BK signaling, based on , , ,, , and the present study (2011, Rattus norvegicus,Homo sapiens)
• Enzymes of the central metabolism with the biosynthetic pathway of l-valine in C (2011, Corynebacterium glutamicum)
• Temporal regulation of apoptosis in SeV-infected cells by PI3K (2011, NA)
• IRF-3- and Bax-mediated apoptosis acts as a host antiviral response (2011, NA)
• (A–C) Schematics of Wnt signaling components in the absence of a Wnt signal (A), the presence of a Wnt signal (B), and the presence of a Wnt signal blocked by the displacement of Tcf7l2 by dnTcf7l2 (C) (2011, Xenopus laevis,Homo sapiens)
• Proposed in vivo innate and adaptive immune responses to AAV vectors (2011, NA)
• Wnt/Beta-catenin Signaling Pathway (2011, NA)
• Different expressed proteins indicated in glycolysis, TCA cycle, pentose phosphate pathway, nucleotide metabolism, amino acid metabolism, and cell wall development (2011, NA)
• RAF/MEK/ERK and the PI3K/AKT/mTOR signaling pathways are shown (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Hepatitis B virus,NA)
• Potential interactions resulting in myelin abnormalities in SSADH-deficient mice (2011, NA)
• Co-expression network of the ET biosynthesis and signaling pathways (2011, Arabidopsis thaliana,Pseudomonas syringae)
• Visual representation of the JA/SA/ET biosynthesis and signaling pathways (2011, Arabidopsis thaliana,Pseudomonas syringae)
• Pathway of alcoholic injury resulting in the direct production of oxidative stress and the LPS-TLR pathway that culminates in production of cytokines and other inflammatory processes that result in hepatitis of the liver (2011, NA)
• Integrated Bio-Entity Network: A System for Biological Knowledge Discovery (2011, NA)
• Mechanism of action of aspirin as a treatment for ALPS (2011, NA)
• Interaction of MSCs and HSCs (2011, NA)
• Proteomic Analysis of Pathways Involved in Estrogen-Induced Growth and Apoptosis of Breast Cancer Cells (2011, Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis,Lareunionomyces loeiensis,vectors)
• Estrogenic effects on gp130 signaling (2011, Homo sapiens)
• Schematic diagrams of the signal transduction in TCDD-induced MUC5AC gene expression and the conventional AhR pathway in the activation of CYP1A1 expression (2011, Homo sapiens)
• Oxytocin receptor linked signaling pathways resulting in myometrial contraction (2011, NA)
• Transcription factor NFKB regulates the cellular response to inflammatory and oxidant stress, as well as stretch (2011, NA)
• Signal transduction pathways for itch (2011, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Castor fiber,Homo sapiens,Mucuna pruriens)
• Profiling experiments and pathway analysis (2011, NA)
• Metabolism pathway of tamoxifen and its interaction with estrogen receptors.Copyright © 2009 (2011, NA)
• XRCC1 is instrumental in base excision repair (BER) of small oxidative lesions and a related mechanism for the repair of single-strand breaks (SSB-R), both caused by ionizing radiation (2011, NA)
• Plastidial isoprenoid biosynthesis pathway detailing the level of co-expression that PSY shares with individual interrelated isoprenoid biosynthesis pathway genes (2011, NA)
• Perturbation of neural Ca2+ homeostasis under ischemic conditions (2011, NA)
• NK2 homeobox 1 (NKX2-1)–Sam Pointed Domain Ets-like Factor (SPDEF)–associated gene network analyzed using Ingenuity Pathway Analysis (2011, Homo sapiens,Mus musculus)
• Comparison of cAMP-PKA and MAPK signaling cascades in C (2011, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Homo sapiens)
• Proposed three pathways for the mechanism of nicotinic acetylcholine receptor (nAChR)-mediated survival signal transduction (2011, NA)
• Key cellular signaling cascades regulating morphogenesis in C (2011, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Homo sapiens)
• F igure 1.— (2011, Drosophila melanogaster,Homo sapiens)
• Regulation of TTP expression by CK2 (2011, NA)
• Map of cytoskeleton remodeling pathway (Genego Metacore, fragment) overlapped with quantile-normalized estimations of protein abundance (2011, NA)
• Two proposed initiation models of canonical Wnt/Beta-catenin signalling pathways (2011, Homo sapiens,Xenopus laevis,Lareunionomyces loeiensis)
• Functions related to hepatic cultures.Subgraphs of a hepatocyte response network induced by genes annotated with MSigDB gene sets (2011, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae)
• Proposed schematic of the roles of NIK and SMG1 in sensitive versus resistant cells in response to SMC and TNFA treatment (2011, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus)
• Sample subnetwork formation (2011, NA)
• Proposed mechanism for VEGFA165 induced tumour growth (2011, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• IL-33 release and signaling via ST2L (2011, NA)
• Graded Nodal/Activin Signaling Titrates Conversion of Quantitative Phospho-Smad2 Levels into Qualitative Embryonic Stem Cell Fate Decisions (2011, NA)
• The interplay between leptin, IGF-1 and AB42 (2011, NA)
• Biosynthetic pathway for 2-AG (2011, NA)
• P53 activation by NML-MYBBP1A in response to glucose limitation (2011, NA)
• Drug inhibition of signalling pathways (2011, NA)
• Local regulatory proteins that mediate some of the actions of TGFB in human myometrium and leiomyoma (2011, NA)
• Simplified scheme of the possible involvement of cAMP/PKA pathway in cancer (2011, NA)
• Nerve growth factor (NGF) signaling in breast cancer cells (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Signalling pathways in oesophageal adenocarcinoma (2011, NA)
• MicroRNA Expression Profiling Reveals MiRNA Families Regulating Specific Biological Pathways in Mouse Frontal Cortex and Hippocampus (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Illustration of main mechanisms of trastuzumab resistance (in red) and targeted agents to circumvent resistance (in blue) (2011, Homo sapiens)
• Cytosolic RNA sensors (2011, NA)
• CREM-ACT-KIF17b regulatory pathway (2011, Mus musculus,Drosophila melanogaster,Homo sapiens)
• Apoptosis or parthanatos cell-death pathways (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Gallus gallus,Eucalyptus intertexta)
• Dysregulated TRK Signalling is a Therapeutic Target in CYLD Defective Tumours (2011, NA)
• Plasmodium falciparum-Infected Erythrocytes and IL-12/IL-18 Induce Diverse Transcriptomes in Human NK Cells: IFNA/B Pathway versus TREM Signaling (2011, Plasmodium falciparum,Homo sapiens)
• TGFB signaling pathway (2011, NA)
• Possible mechanisms of involvement of nuclear receptor LRH-1 in development of pancreatic cancer (2011, Homo sapiens)
• CDK5 (A) and actin (B) signaling pathway in primary neurons (2011, Mus musculus,Homo sapiens)
• Schematic diagram summarizing the main results obtained in the present study (A) and in a previous report by Oviedo-Boyso et al (2011, Staphylococcus aureus)
• Tenofovir handling by proximal tubular cells and potential molecular mechanisms and clinical consequences of tenofovir nephrotoxicity (2011, NA)
• Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events (2011, Bos taurus,Sus scrofa,Equus caballus,Bubalus bubalis,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca radiata,Escherichia coli,Sequoia sempervirens)
• Hypothesis of inhibitory signaling of sesamol in platelet activation (2011, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus asinus,Armoracia rusticana,Helianthus annuus,Sesamum indicum,Mus musculus,Rattus norvegicus,Homo sapiens,Staphylococcus aureus,Human gammaherpesvirus 4)
• Gene Expression Profiling of Preovulatory Follicle in the Buffalo Cow: Effects of Increased IGF-I Concentration on Periovulatory Events (2011, Bos taurus,Sus scrofa,Equus caballus,Bubalus bubalis,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca radiata,Escherichia coli,Sequoia sempervirens)
• Schema flowchart illustrating the role of HSP90A in the mechanisms of cellular survival (2011, NA)
• Alteration to activity of the Akt/GSK3B signalling pathway can explain a number of the changes observed in microarray analysis of flies expressing rCAG, rCUG and rAUUCU repeats in the nervous system (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Drosophila melanogaster,Triportheus paranensis)
• Toll-like receptor-4 (TLR-4) signaling via MyD-88-dependent pathways (2011, NA)
• OB inhibition by MM cells (2011, NA)
• Fatty Heart, Cardiac Damage, and Inflammation (2011, NA)
• Epidermal growth factor receptor (EGFR) crosstalk (2011, NA)
• The cross-talk between IKK family members in the MyD88 signaling pathway (2011, Mus musculus,Homo sapiens)
• Innate immunity against RNA viruses in mammals (2011, NA)
• Genome Characterization of the Oleaginous Fungus Mortierella alpina (2011, Mortierella alpina,Saccharomyces cerevisiae,Arabidopsis thaliana,Solanum tuberosum,Candida albicans,Schizosaccharomyces pombe,Aspergillus fumigatus,Magnoliopsida,Aspergillus nidulans,Botrytis cinerea,Cryptococcus neoformans,Neurospora crassa,Yarrowia lipolytica,Saccharomyces cerevisiae S288C,Fusarium oxysporum,Aspergillus oryzae,Fusarium graminearum,Ustilago maydis,Pyricularia grisea,Fusarium verticillioides,Sclerotinia sclerotiorum,Rhizopus arrhizus,Scheffersomyces stipitis,Fusarium solani,Mucor circinelloides,Eremothecium gossypii,Trichoderma atroviride,Fusarium graminearum PH-1,Coprinopsis cinerea,Aspergillus fumigatus Af293,Aspergillus oryzae RIB40,Laccaria bicolor,Candida albicans SC5314,Schizosaccharomyces pombe 972h-,Aspergillus niger ATCC 1015,Aspergillus niger CBS 513.88,Candida albicans 12C,Aspergillus nidulans FGSC A4,Aspergillus fischeri NRRL 181,Yarrowia lipolytica CLIB122,Nakaseomyces glabratus CBS 138,Aspergillus clavatus NRRL 1,Botrytis cinerea B05.10,Neurospora crassa OR74A,Trichoderma reesei QM6a,Aspergillus fumigatus A1163,Batrachochytrium dendrobatidis,Ustilago maydis 521,Phanerochaete chrysosporium RP-78,Eremothecium gossypii ATCC 10895,Mortierella alpina ATCC 32222,Kluyveromyces lactis NRRL Y-1140,Scheffersomyces stipitis CBS 6054,Omphalotus olearius,Pyricularia oryzae 70-15,Debaryomyces hansenii CBS767,Fusarium verticillioides 7600,Laccaria bicolor S238N-H82,Schizosaccharomyces octosporus,Podospora anserina S mat,Phytophthora infestans T30-4,Trichoderma virens Gv29-8,Malassezia globosa CBS 7966,Fusarium oxysporum f. sp. conglutinans Fo5176,Sclerotinia sclerotiorum 1980 UF-70,Botrytis cinerea T4,Cryptococcus neoformans var. neoformans B-3501A,Schizosaccharomyces japonicus yFS275,Vanderwaltozyma polyspora DSM 70294,Schizosaccharomyces cryophilus OY26,Batrachochytrium dendrobatidis JAM81,Podila verticillata,Homo sapiens,Rattus norvegicus,Agrobacterium tumefaciens,NA,NA)
• Map of the molecular mechanisms of apoptosis (2011, Homo sapiens,Caenorhabditis elegans,Ovis aries)
• Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 240 relative to −15 d postpartum (2011, NA)
• Signaling cascades that regulate the intrinsic and extrinsic pathways of apoptosis (2011, NA)
• Activation of NFKB and regulation of downstream transcriptional antioxidant and pro-oxidant targets (2011, NA)
• Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 60 relative to −15 d postpartum (2011, NA)
• Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis (2011, NA)
• Gene Expression Profiling of Embryonic Human Neural Stem Cells and Dopaminergic Neurons from Adult Human Substantia Nigra (2011, NA)
• Suggested model for RF effects and interactions in various mouse tissues (2011, NA)
• Crosstalk of ROS with NFKB signaling pathways (2011, NA)
• Classical and alternative NFKB pathways in skeletal cells (2011, NA)
• Ephrin and neurotrophin signaling pathways in primary neurons (2011, Mus musculus,Homo sapiens)
• Pathway for the transduction of mechanical signals that regulate SmMHC expression and the interaction of this pathway with the IL-13-activated signaling pathway (2011, NA)
• Schematic overview of the multifunctional roles of c-FLIP in the TRAIL-triggered apoptosis pathway as well as activating various anti-apoptotic and cell survival signaling pathways (2011, NA)
• Mammalian MAPK signaling pathways (2011, NA)
• Crosstalk between RANKL- and TNF-induced NFKB signaling in OCs (2011, NA)
• Overall results depicted in the networks of AA and glucose transporters and mTOR, Jak2-Stat5, insulin, and AMPK signaling with log2 fold change at 15 relative to −15 d postpartum (2011, NA)
• The networks of factors (genes product, hormones, and metabolites) potentially involved in the regulation of milk protein synthesis in lactating bovine mammary tissue (2011, NA)
• NFKB signaling pathways initiated by TLR4, TCR, TNF receptor 1, CD40 and genotoxic stress (2011, NA)
• NAD+ biosynthesis and salvage pathways (2011, Homo sapiens)
• Canonical and non-canonical NFKB signaling pathways (2011, NA)
• Pleiotropic functions of EAPII/TTRAP/TDP2 (2011, NA)
• NIRF interaction network (2011, Homo sapiens)
• Metabolic remodeling in cancer cells and regulation by signaling pathways involving oncogenes and tumor suppressor genes (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,NA)
• Schematic diagram represents the ischemic preconditioning pathway in cardiomyocytes (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Cavia porcellus,Homo sapiens,Gallus gallus)
• NIK stabilization as a mechanism of non-canonical NFKB signaling (2011, NA)
• NFKB activation by the canonical pathway (2011, NA)
• Expanding role of ubiquitination in protein kinase activation in diverse NFKB pathways (2011, NA)
• NFKB activation in pathogenesis and therapy of cancer (2011, Homo sapiens,Mus musculus)
• LTP and LTD: Schematic of molecular mechanisms (2011, NA)
• NFKB signaling module consisting of canonical and non-canonical pathways (2011, NA)
• Ingenuity Pathway Analysis of epidermal genetic information retrieval-harvested melanoma specimens identifies overexpressed genes involved in melanocyte development and pigmentation (2011, Homo sapiens,Drosophila melanogaster,Sequoia sempervirens)
• Implications of Relationships between Human Diseases and Metabolic Subpathways (2011, NA)
• MAPK signaling pathway (2011, NA)
• Proposed model of the mechanism by which cilostazol increases cAMP accumulation and ATP release from type 2 diabetes erythrocytes (2011, Homo sapiens,Cricetus cricetus)
• The miR-29 regulatory network in Zmpste24−/− progeroid mice (2011, Mus musculus,Homo sapiens)
• Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays (2011, NA)
• Pathway for getifinib and docetaxel to generate the synergistic effects on KRT8 (2011, NA)
• Sample queries from our experiments (2011, Bos taurus,Canis lupus familiaris,Sus scrofa,Ornithorhynchus anatinus,Homo sapiens,Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Pan troglodytes)
• Inhibitory role of Smad7 in renal fibrosis and inflammation (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGFB/Smads and crosstalk pathways in renal fibrosis and inflammation (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Physiological regulatory pathways of NKCC2 in thick ascending limbs of Henle's loop (TALs) (2011, NA)
• Oncogenic CagA Promotes Gastric Cancer Risk via Activating ERK Signaling Pathways: A Nested Case-Control Study (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Helicobacter pylori,Corynebacterium phage gamma)
• Comprehensive Association Analysis of Homocysteine Metabolic Pathway Genes in Singaporean Chinese with Ischemic Stroke (2011, NA)
• DSBs in S and G2 phases of the cell cycle, collapsed replication forks, and daughter-strand gaps all require HR for their repair (2011, NA)
• Mitochondrial and Fas death receptor apoptotic pathways to apoptosis before (A) and after (B) MUN insult at term gestation in rats (2011, NA)
• Inhibition of HMG-CoA reductase by statins on the cholesterol biosynthesis pathway (2011, NA)
• Signaling pathway for adenosine receptors (2011, NA)
• Regulation of TPL-2 through IKK-induced p105 proteolysis (2011, NA)
• Signaling Pathways Altered in Hepatic Cancer Stem Cells (2011, NA)
• PI3K pathway activates different processes that regulate proliferation, apoptosis and migration (2011, NA)
• Conserved Regulation of p53 Network Dosage by MicroRNA–125b Occurs through Evolving miRNA–Target Gene Pairs (2011, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Caenorhabditis elegans,Danio rerio,NA)
• Scheme of the signal transduction pathway in response to DNA damage (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Apoptosis pathways (2011, NA)
• Intrinsic and extrinsic pathways of apoptosis (2011, NA)
• Model describing the proposed role of Rap1GAP in the control of GDNF-induced Ret signaling (2011, NA)
• Molecular mechanism of autophagy and its role in cell death and survival (2011, NA)
• TGFB pathway genes in iMYC cells (2011, Homo sapiens)
• Hypothetical molecular signaling pathways of the expression of p27 by which moderate increase in the concentration of D-(+)-glucose down-regulates and deficiency of D-(+)-glucose or L-leucine up-regulates the expression of p27 (2011, NA)
• Toll-Like Receptor 2 Pathway Regulates the Ppargc1a/b Metabolic Co-Activators in Mice with Staphylococcal aureus Sepsis (2011, NA)
• Regulation of the early myogenic transcriptional program by the kinome (2011, NA)
• Regulation of the late myogenic transcriptional program by the kinome (2011, NA)
• Regulation of neural process growth, elaboration and structural plasticity by NFKB (2011, NA)
• Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases (2011, Homo sapiens,Rattus norvegicus)
• Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases (2011, Homo sapiens,Rattus norvegicus)
• NKCC2 regulation (2011, Homo sapiens,Mus musculus)
• Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer (2011, NA)
• The lymphocte-specific gene (A) or urine peptide (B) markers (2011, Homo sapiens,Sequoia sempervirens,clinical samples)
• GW501516, a PPARD Agonist, Ameliorates Tubulointerstitial Inflammation in Proteinuric Kidney Disease via Inhibition of TAK1-NFKB Pathway in Mice (2011, Mus musculus,Rattus norvegicus,Armoracia rusticana,Glycine max,Homo sapiens,Bos taurus)
• Titin domain arrangement in the cardiac sarcomere and connectivity within a mechanical signaling network (2011, NA)
• ECM-receptor interaction and focal adhesion pathway (2011, NA)
• Regulated necrosis in the intestine of FADDIEC-KO mice (2011, NA)
• Summary of the signaling pathway mediated by RET (2011, Homo sapiens,Mus musculus)
• TLR4 signaling pathway: TLR4 is localized on cell surface for ligand recognition and activates both MyD88-dependent pathway and TRIF-dependent pathway (2011, Mouse mammary tumor virus,Respiratory syncytial virus,Measles morbillivirus,Murid betaherpesvirus 1,Mus musculus,Rattus norvegicus,Cricetus cricetus,Saccharomyces cerevisiae,Gallus gallus,Canis lupus familiaris,Candida dubliniensis,Ovis aries,Plasmodium falciparum,Toxoplasma gondii,Myxine glutinosa,Homo sapiens,Borreliella burgdorferi)
• Host cell machinery gets activated during influenza infection and leads to trigger Signaling pathways (2011, NA)
• Signalling pathway activated by B1R agonists leading to iNOS-derived high output nitric oxide (2011, NA)
• Simplified cartoons illustrating the components of the cullin–RING E3 ligases (CRLs) (2011, NA)
• Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferonG on human neutrophils and monocytes (2011, NA)
• BMP signaling and its blocking (2011, NA)
• Feedback mechanisms regulating adult midgut homeostasis and regeneration in Drosophila (2011, NA)
• A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1 (2011, NA)
• Overrepresented miRNA regulatory pathways in PKD (2011, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae)
• Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway displaying transcripts in mitogen-activated protein kinase (MAPK) signaling pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Xenopus laevis)
• Modeled miRNA mediated pathways in the pathogenesis of lung fibrosis (2011, NA)
• Regulation of MeCP2 expression by Bdnf (2011, NA)
• Unraveling Molecular Signatures of Immunostimulatory Adjuvants in the Female Genital Tract through Systems Biology (2011, NA)
• RNAi Effector Diversity in Nematodes (2011, Drosophila melanogaster,Caenorhabditis elegans,Schistosoma mansoni,Meloidogyne javanica,Ascaris suum,Haemonchus contortus,Trichinella spiralis,Meloidogyne incognita,Caenorhabditis briggsae,Brugia malayi,Heligmosomoides polygyrus,Pristionchus pacificus,Paramecium tetraurelia,Caenorhabditis remanei,Ancylostoma caninum,Globodera pallida,Caenorhabditis brenneri,Meloidogyne hapla,Ostertagia ostertagi,Caenorhabditis japonica,Oesophagostomum dentatum,Arabidopsis thaliana,Neurospora crassa,Cryptomeria japonica,Homo sapiens,bacterium 1-7A,NA)
• Novel pathway of PKC and MAPK-mediated transcriptional activation of iNOS in LPS-treated BV-2 cells (2011, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetulus griseus,Listeria monocytogenes,Escherichia coli O111B4,Homo sapiens,Armoracia rusticana,Human immunodeficiency virus 1)
• Schematic diagram to show that knockdown of Akt1 leads to upregulation of Akt2 in response to oxidative stress and its regulation of oxidative-stress-induced apoptosis through three pathways (2011, NA)
• Mechanisms regulating PI3K pathway in melanoma (2011, Homo sapiens,Mus musculus)
• Key therapeutic targets in the PI3K/Akt and MAPK pathways together with pharmacological agents inhibiting members of these signaling cascades (2011, Homo sapiens,Mus musculus)
• Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy (2011, NA)
• Microarray Analysis in a Cell Death Resistant Glioma Cell Line to Identify Signaling Pathways and Novel Genes Controlling Resistance and Malignancy (2011, NA)
• RTK/PI3K/Akt signaling (2011, NA)
• Two conserved branches of the canonical Wnt pathway (2011, NA)
• HIPK2 and NLK/LIT-1 in Wnt signaling (2011, NA)
• Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway display transcripts in cell cycle pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Xenopus laevis)
• S-glutathionylation as a regulator for Ras-mitogen-activated protein kinase pathways in cancer (2011, NA)
• CHK1 Inhibitors in Combination Chemotherapy (2011, NA)
• Comparative pathway networks of cyclic genes in mouse, chicken and zebrafish (2011, Gallus gallus,Danio rerio,Mus musculus,Homo sapiens)
• Gene regulatory network model for specification of the skeletogenic mesoderm lineage (2011, Echinoidea,Asteroidea)
• Proposed model of GSK3 activation by amyloidB protein in AD (2011, NA)
• P53 pathway and retinoblastoma (RB) tumor suppressor protein signaling are shown (2011, NA)
• Aberrant Signaling Pathways in Glioma (2011, NA)
• Schematic of IL-6 and IL-6 receptor interactions (2011, NA)
• HOG and CWI pathways (2011, Homo sapiens,Saccharomyces cerevisiae,Mouse mammary tumor virus)
• Action of the enteropathogenic yersiniae Ysc T3SS effectors (Yops) on host cell signaling and survival (2011, Escherichia coli,Pseudomonas aeruginosa,Campylobacter jejuni,Escherichia coli O157H7,Yersinia pestis,Yersinia enterocolitica,Yersinia pseudotuberculosis,Campylobacter coli,Halobacillus halophilus,Yersinia enterocolitica subsp. palearctica,Bos taurus,Canis lupus familiaris,Sus scrofa,Ovis aries,Lepus americanus,Lepus capensis,Lepus europaeus,Mus musculus,Rattus norvegicus,Ondatra zibethicus,Homo sapiens,Gallus gallus,clinical samples,Musca domestica)
• Cell cycle pathway represented in KEGG (2011, Nicotiana tabacum,Vaccinium macrocarpon,Homo sapiens,Mus musculus,Escherichia coli,Molva molva)
• Pre- and postsynaptic mechanisms involved in neuronal plasticity and the role of GSK3 (2011, NA)
• Francisella tularensis tularensis targets the PI3K/Akt pathway at multiple levels (2011, NA)
• Figure shows the complex interplay involving RAGE, reactive oxygen and nitrogen species, antioxidants, profibrotic cytokines, and their signalling pathways, and, in red, the most relevant effects of pathway activation (2011, NA)
• Ingenuity Pathway Analysis identified ERK as the Top network signaling Hub where the shaded shapes indicate the candidate genes from the present study (2011, Bos taurus,Mustela putorius furo,Homo sapiens,Bikinia letestui,Treponema medium)
• Prolactin Regulation of the Prostate Gland: A Female Player in a Male Game (2011, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples,Betapolyomavirus macacae)
• Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer (2011, NA)
• Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer (2011, NA)
• Autism-Associated Gene Expression in Peripheral Leucocytes Commonly Observed between Subjects with Autism and Healthy Women Having Autistic Children (2011, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Mouse mammary tumor virus)
• Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice: Similarities in the Molecular Landscape with Human Liver Cancer (2011, NA)
• Human Polynucleotide Phosphorylase (hPNPaseold-35): An evolutionary conserved gene with an expanding repertoire of RNA degradation functions (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,Caenorhabditis elegans,Spinacia oleracea,Hippospongia communis,Streptomyces antibioticus,Homo sapiens)
• Ingenuity Pathway Analysis identified MapK as second Top network signaling Hub where the shaded shapes indicate the candidate genes from current study (2011, Bos taurus,Mustela putorius furo,Homo sapiens,Bikinia letestui,Treponema medium)
• Ingenuity Pathway Analysis identified NFKB as the Top Network signaling Hub where the shaded shapes indicate the candidate genes from the present study (2011, Bos taurus,Mustela putorius furo,Homo sapiens,Bikinia letestui,Treponema medium)
• 1,25(OH)2D3 intracellular signalling pathway (2011, Mus musculus,Homo sapiens)
• Predictive Power Estimation Algorithm (PPEA) - A New Algorithm to Reduce Overfitting for Genomic Biomarker Discovery (2011, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Rattus norvegicus)
• Possible role of Kynurenine pathway involvement in dopaminergic neurodegenerative process through microglia activation: Parkinson's disease is associated with chronic activation of microglia, which also can be induced by LPS or Rotenone treatments (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Host cell death pathways targeted by L (2011, Salmonella enterica subsp. enterica serovar Typhimurium,Chlamydia trachomatis,Legionella pneumophila,Saccharomyces cerevisiae,Caenorhabditis elegans,Vasconcellea candicans,Dictyostelium discoideum,Homo sapiens,Mus musculus)
• The activated neuronal populations—identified with c-Fos—in the barrel cortex following whisker stimulation and how the different neuronal populations contribute to the evoked CBF response (2011, NA)
• Striatal plasticity induced in glutamatergic synapses onto both striatonigral and striatopallidal MSN populations in response to concomitant D2 and A2A receptor modulation (2011, NA)
• Signaling pathways in angiogenesis (2011, NA)
• Simplified TGFB signaling pathways (2011, Homo sapiens,Mus musculus)
• Functional pathway analysis of glycoproteins overexpressed in PC3-N2 (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Proposed regulatory pathways involving two transcriptional activators, TSF1 and EfSTE12, and leading to the production of elsinochrome (ESC) and conidia in Elsinoë fawcettii (2011, Citrus sinensis,Citrus aurantium,Elsinoe fawcettii,Siphonodon australis,Elsinoe australis)
• Membrane type-MMPs regulate vascular cell signaling in cancer (2011, NA)
• IFN signaling pathway coded with identified proteins on day 7 postinfection (2011, NA)
• Delay in apoptosis at 9 hr (2011, Bos taurus,Sus scrofa,Homo sapiens,Salmonella enterica subsp. enterica serovar Typhimurium)
• Transcripts (p < 0.05) involved in cell signaling (2011, NA)
• Inhibition of the type I interferon (IFN) induction and signaling pathways by viral proteins of KSHV (2011, Human gammaherpesvirus 8)
• VEGF-VEGFR signaling in lymphangiogenesis (2011, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Sus scrofa,Cavia porcellus,Felis catus,Homo sapiens,Candida dubliniensis)
• Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration (2011, Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Streptococcus pyogenes,Bacillus anthracis,Acinetobacter baumannii,Neisseria meningitidis,Neisseria gonorrhoeae,Enterococcus faecium,Streptococcus sp. group A,Streptococcus agalactiae,Streptococcus sp. group B,Corynebacterium diphtheriae,Streptococcus agalactiae NEM316,Acinetobacter baumannii LY6,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Diaporthe sclerotioides,Coxsackievirus B3,Macrovipera lebetina)
• Targeted therapies for breast cancer (2011, NA)
• Model proposed to explain why BDNF fails to regulate local translation in the hippocampus of Ts1Cje mice (2011, Mus musculus,Homo sapiens)
• Schematic model of crosstalk between oxysterol and Wnt pathways on the expression of myelin genes MPZ and PMP22 (2011, Mus musculus,Homo sapiens)
• Tau signaling cascade in LPA induced neurite retraction in differentiated Neuro2a cells (2011, NA)
• Comparative analysis of plastid transcriptomes in cucumber (2011, Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,PX clade,Cucumis sativus,Magnoliopsida,Medicago truncatula,Spinacia oleracea,Chlamydomonas reinhardtii,Populus trichocarpa,Physcomitrium patens,Lotus japonicus,Lactuca sativa,Euglena gracilis,Marchantia polymorpha,Cyanidioschyzon merolae,Bos taurus,Middle East respiratory syndrome-related coronavirus,Homo sapiens)
• Crosstalk between COX-2 and EGF signaling pathway in CRC (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Genetic alterations in glioblastoma signal transduction pathways (adapted from Parsons et al) (2011, NA)
• Proposed model showing the interactions of Nm23-H1 with cellular pathways (2011, NA)
• Putative mechanisms underlying the neuroprotective effects of TGF‐B1 against AB‐induced neurodegeneration (2011, NA)
• Novel Roles of cAMP Receptor Protein (CRP) in Regulation of Transport and Metabolism of Carbon Sources (2011, NA)
• Two major pathways to caspase activation in vertebrates: the death receptor or extrinsic pathway, engaged by the indicated members of the TNF receptor family on the cell surface, and the Bcl-2-regulated mitochondrial or intrinsic pathway (2011, NA)
• Proposed pathway of the interaction between nitric oxide (NO) and hydrogen sulphide (H2S) in endothelial cells during angiogenesis (2011, NA)
• Apoptotic processes in PD (2011, NA)
• The involvement of zinc metalloproteinases in AB metabolism (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli,prion)
• Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana,Clostridium perfringens)
• RhoA/ROCK I pathway and remodeling of microtubule network underlie the polarization and migration of HSPCs (2011, NA)
• The activity-dependent control of Ca2+/calmodulin (CaM) regulated neuronal nitric oxide synthase (nNOS) signaling and function (2011, NA)
• Simplified diagrams for agrin-induced signaling (2011, NA)
• RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice (2011, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Glycine max,Embryophyta,Magnoliopsida,Allium cepa,eudicotyledons,Bryophyta,Picea sitchensis,Amborella trichopoda,Adiantum capillus-veneris,Aristolochia fimbriata,Nuphar advena,Syntrichia ruralis,Homo sapiens,Oryctolagus cuniculus,vectors,Cauliflower mosaic virus)
• Interplay between Wnt, Nurr1 and En1 signaling in vitro and in vivo (2011, Gallus gallus,Danio rerio,Xenopus laevis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Signal Transduction pathway for STAT3 (2011, NA)
• Pathways of steroid hormone synthesis, metabolism and tissue sensitivity to HRT (Kelemen et al., 2008; Pasqualini and Chetrite, 2005; Masson et al., 2010) MiRNA's predicted to target steroidogenic or metabolizing enzymes are encased in blue (2011, NA)
• Proposed signalling mechanism for the effects of kaempferol on LPS-induced neuroinflammation in BV2 cells (2011, NA)
• RNF8‐ and RNF168‐dependent ubiquitin signaling pathway at DSBs is stimulated by CHD4‐ and p400‐mediated chromatin remodeling (2011, NA)
• Regulation of PTEN/PI3K/AKT pathway by microRNAs (2011, NA)
• Signaling molecules implicated in epilepsy (see the text for the detail) (2011, NA)
• Genetic mutations of signaling molecules implicated in mTOR pathway (red Xs) (2011, NA)
• PI3K signalling regulates both choline and glucose metabolism (2011, NA)
• Double-stranded and single-stranded RNA signaling pathway (2011, NA)
• MTOR signaling pathway (2011, NA)
• Schematic summarizing the role of signaling Smads in epithelial carcinogenesis (2011, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Mechanism of B7-H4 action in islet transplantation (2011, NA)
• Summary of the common pathways underlying neurodegenerative diseases and cancer that are mediated by miRNAs (2011, NA)
• miRNAs regulate DSB DDR through modulating the core protein components of various pathways (2011, NA)
• RAF‐MEK‐ERK signaling pathway (panel A) and activation via constitutive BRAF activation (panel B) (McCubrey et al., 2007) (2011, Homo sapiens)
• Endocrine, paracrine and autocrine regulation of the IGF-1R pathway and therapeutic strategies for its disruption (2011, NA)
• Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Inhibitory Actions of Anti-Müllerian Hormone (AMH) on Ovarian Primordial Follicle Assembly (2011, NA)
• Proposed model (2011, Mus musculus,Adenoviridae,Homo sapiens)
• Computational Identification of Transcriptional Regulators in Human Endotoxemia (2011, NA)
• Proposed model shows the requirement of the IL-4RAlpha-Jak2-mediated signaling pathway for IL-13-induced M2 gene expression in human monocytes/macrophages (2011, Homo sapiens,Candida dubliniensis)
• Working model for the ATF4-dependent and c-JUN-dependent AA signaling pathways (2011, NA)
• RA-dependent non-transcriptional involvement in neurite outgrowth (2011, NA)
• Relationships of different neurons in the striatum and neurotransmitter signaling involved in interval timing (2011, NA)
• Proposed model for the regulation of Dpr genes (2011, Aspergillus fumigatus,Homo sapiens)
• Campylobacter jejuni-induced Cdc42 activation (2011, NA)
• Effect of SCGB3A2 on TGFB signaling pathway (2011, NA)
• Schematic showing the involving cAMP-PI3K-PKB-MEK-ERK1/2-TRPC6 signal transduction pathway (2011, Rattus norvegicus,Homo sapiens)
• Model pathway for genistein-induced ASAH1 transcription in MCF-7 cells (2011, NA)
• Intracellular pathway of folate metabolism with highlighted critical pathways of methotrexate (MTX) entry, effect and efflux (2011, Homo sapiens)
• Ciliary Neurotrophic Factor Induces Genes Associated with Inflammation and Gliosis in the Retina: A Gene Profiling Study of Flow-Sorted, Müller Cells (2011, NA)
• Tim-3 Negatively Regulates IL-12 Expression by Monocytes in HCV Infection (2011, NA)
• Pathway context for RME modules found in glioblastoma (2011, NA)
• Ecdysone signalling in ovarian stem cell niche (2011, Saccharomyces cerevisiae,Diaporthe sclerotioides,Olea europaea,Matthiola incana,Prunus domestica,Citrus aurantiifolia,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke (2011, NA)
• Network of upregulated genes in C2C12 cells treated with rhBMP2 and rhBMP7 using the STRING 9.0 pathway analyzer (2011, NA)
• Pathways that regulate aging (2011, NA)
• Intracellular signaling pathways regulating growth (2011, NA)
• Hypothesized mechanisms for sphingolipids in cardioprotective signaling in response to ischemia or hypoxia (2011, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Proposed model of NPR-A signaling-mediated maintenance of ES cell self-renewal and pluripotency (2011, NA)
• Beta-Adrenergic Receptor-PI3K Signaling Crosstalk in Mouse Heart: Elucidation of Immediate Downstream Signaling Cascades (2011, NA)
• Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes (2011, NA)
• Patient-Specific Data Fusion Defines Prognostic Cancer Subtypes (2011, NA)
• In individuals with high macrophage aggregation around dead adipocytes as CLS, activation stimuli such as IL-1, lipopolysaccharide (LPS) and lipopolysaccharide binding protein (LBP), and TNFA bind to their appropriate membrane receptors (2011, NA)
• Cell cycle pathway and the significant genes on cell cycle-related miRNAs (2011, NA)
• Adapted from (2011, Saccharomyces cerevisiae,Arabidopsis thaliana,Venustaconcha ellipsiformis,Homo sapiens)
• Preimplantation development pathway (2011, Bos taurus,Drosophila melanogaster,Eutheria,Eumetazoa,Homo sapiens,Mus musculus,Syringa vulgaris,Euteleostomi)
• Canonical IL-6 signaling versus IL-6 trans-signaling in tumor progression and metastases (2011, Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Mycobacterium tuberculosis,Ovis aries,Homo sapiens)
• Factors that increase IL-6 production in response to various stimuli (2011, Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Mycobacterium tuberculosis,Ovis aries,Homo sapiens)
• Simplified illustration of the physiological pathways used for H2 production in Chlamydomonas (Adapted from The Chlamydomonas Sourcebook ) (2011, NA)
• Endogenous and exogenous regulators of TLR activation (2011, Human alphaherpesvirus 1,unidentified influenza virus,Mouse mammary tumor virus,Respiratory syncytial virus,Vesicular stomatitis virus,West Nile virus,Measles morbillivirus,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Encephalomyocarditis virus,Reovirus sp.,ssRNA viruses,Mengo virus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Candida dubliniensis,Trypanosoma cruzi,Borreliella burgdorferi,Homo sapiens,Mus musculus,synthetic RNA)
• Oncogenes and tumor suppressors regulates the mTORC1-signaling pathway (2011, NA)
• The role of activity-dependent Ca2+signaling in PACAP-mediated neuroprotection (2011, NA)
• PKA pathway in Saccharomyces cerevisiae (2011, NA)
• MTORC1 pathway controls cellular metabolism (2011, NA)
• Regulation of the estrogen signaling pathway inside the nucleus (2011, Homo sapiens)
• EGFR biology (2011, Homo sapiens)
• GSK-3B in the regulation of microglial phagocytosis (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,prion)
• GSK-3B regulates the production of microglial inflammatory molecules (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,prion)
• De novo Biosynthesis of Biodiesel by Escherichia coli in Optimized Fed-Batch Cultivation (2011, NA)
• The Hog pathway models of Mettetal et al (2011, NA)
• Canonical structure of a MAPK cascade (2011, NA)
• Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression (2011, Mus musculus,Chlorocebus aethiops,Homo sapiens)
• Novel D opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons (2011, NA)
• Comparison of the pathway of programmed cell death in C (2011, NA)
• Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling (2011, NA)
• TRPM2: a multifunctional ion channel for calcium signalling (2011, Mus musculus,Homo sapiens)
• Genetics of Mechanosensation in the Heart (2011, Danio rerio,Cyprinus carpio,Mustela lutreola,Osphranter robustus,Homo sapiens,Mus musculus)
• Schematic diagram of signaling pathway in mast cells activated by antigen/antibody reaction and smoke exposure in vivo and in vitro (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Nicotiana tabacum)
• Endoplasmic-Reticulum Calcium Depletion and Disease (2011, NA)
• A3B1-mediated stimulation of the Rac/PAK pathway is required for completion of the myoepithelial cell contraction/relaxation cycle (2011, NA)
• CcpA Ensures Optimal Metabolic Fitness of Streptococcus pneumoniae (2011, Streptococcus pneumoniae,Homo sapiens)
• Participation of Calponin in the Cross Talk between 20-Hydroxyecdysone and Juvenile Hormone Signaling Pathways by Phosphorylation Variation (2011, Drosophila melanogaster,Bombyx mori,Manduca sexta,Tribolium castaneum,Helicoverpa armigera,Rhodnius prolixus,Heliothis virescens,Saccharomyces cerevisiae,Armoracia rusticana,Glycine max,Triticum aestivum,Bos taurus,Oryctolagus cuniculus,Capra hircus,Escherichia coli,Escherichia coli HT115,Homo sapiens)
• Toll-like receptor (TLR) signaling (2011, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Mouse mammary tumor virus,Respiratory syncytial virus,Escherichia coli,Oryctolagus cuniculus,Candida dubliniensis)
• P21 regulation by the PI3-kinase/PTEN signaling pathway (2011, Bos taurus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,vectors)
• RWPs-induced apoptosis involving p73 and UHRF1 deregulation in Jurkat cells and in an in vivo colorectal cancer model (2011, Mus musculus,Rattus norvegicus,Malus domestica,Nigella sativa,Homo sapiens,NA)
• PPCSE induces HO-1 expression through PDGFR/PI3K/Akt cascade in a PC-PLC/PKCD/NADPH oxidase/ROS-dependent manner in bEnd.3 cells (2011, NA)
• IGF1R Signaling in Ewing Sarcoma Is Shaped by Clathrin-/Caveolin-Dependent Endocytosis (2011, Oryctolagus cuniculus,Gallus gallus,Capra hircus,Xenopus laevis,Homo sapiens,Mus musculus)
• Model depicting the generation and consequences of ROS-mediated base damage (2011, NA)
• mTOR regulation pathway involved in hypoxia (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Armoracia rusticana,Capra hircus,Homo sapiens)
• miRNA biogenesis pathways and regulatory networks (2011, Homo sapiens,Caenorhabditis elegans)
• Literature-based connections among genes in altered modules of head and neck squamous cell carcinoma (HNSCC) (2011, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human papillomavirus,Homo sapiens,Citrus macrophylla)
• Examples of the major immune escape mechanisms of different types of cancers displaying the involvement of the PI3K signaling pathway (2011, NA)
• Proinflammatory signaling pathways induced by SP-C BRICHOS mutants (2011, Homo sapiens,Chusquea sp. LC et al. 1309)
• NFKB signal transduction pathway (2011, NA)
• Summary and working model (2011, NA)
• Study schema (2011, NA)
• The proposed molecular events that are affected by Ad-IRF3 in microglia (2011, Human immunodeficiency virus 1,Adenoviridae,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana,NA)
• Determining Signalling Nodes for Apoptosis by a Genetic High-Throughput Screen (2011, NA)
• Different signaling pathways leading to the induction of virus stress-inducible genes (VSIGs) and interferon-stimulated genes (ISGs) (2011, Adenoviridae,Adeno-associated virus,Vesicular stomatitis virus,Vaccinia virus,Measles morbillivirus,Reovirus sp.,Coxsackievirus A21,Mammalian orthoreovirus 3 Dearing,Homo sapiens,Mus musculus,NA)
• Wnts signal through a “canonical” pathway involving Beta-catenin mediated transcriptional regulation (at left) and through “non-canonical” pathways involving calcium and Rac/JNK-mediated signaling (at right) (2011, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mouse mammary tumor virus)
• A proposed model for Cdc5-dependent regulation of Ndt80 (2011, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens,Escherichia coli)
• KEGG pathways used for the influence approach (2011, Homo sapiens,Saccharomyces cerevisiae,Bathymaster signatus)
• Peroxisome proliferator-activated receptor G (PPARG) is a ligand-activated nuclear receptor with potent anti-inflammatory properties that modulates the immune inflammatory response (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Candida dubliniensis,Theobroma cacao,Homo sapiens,Drosophila melanogaster)
• Proposed signaling pathway in normal kidney cells (2011, Mus musculus,Homo sapiens)
• E2 action on D2 receptor (D2R) signaling in the lactotroph (2011, Rattus norvegicus,Homo sapiens)
• Working model to explain the antidiabetic effect of Ad36 (2011, Adenoviridae,Human adenovirus sp.,Homo sapiens,Mus musculus)
• Associations among miR-122-identified targets (2011, NA)
• miR-122 and liver-related functions and diseases (2011, NA)
• Schematic presentation of BAD serine 134 phosphorylation in RAF and RAS mutant tumor cells (2011, NA)
• Schematic model of NFKB activation network (2011, NA)
• Metabolic network used for metabolic flux analysis (2011, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Canis lupus familiaris,Human adenovirus 5,Trichoplusia ni)
• Diagram depicting the participation of RCAN1 in the CREB signaling pathway is shown (2011, Homo sapiens,Rattus norvegicus)
• Schematic diagram illustrating some of the major abnormalities related to sensitized D1R-signaling and associated to LID (2011, NA)
• Graphical representation of the IL-6 signaling pathway reveals significant gene expression changes following sarin-induced seizure (2011, NA)
• Emerging molecular functions of RASSF8 (2011, Homo sapiens)
• In silico analysis and gene expression studies suggests functional coupling between FTO and the BDNF/NTRK2-signalling pathway (2011, NA)
• Manipulation of macrophage signaling pathways by L (2011, NA)
• Wnts exert both pre- and post-synaptic effects (2011, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mouse mammary tumor virus)
• General scheme of the SBP in Tritryps (2011, Trypanosoma cruzi,Trypanosoma brucei,Leishmania major,Leishmania infantum,Glossina morsitans,Leishmania major strain Friedlin,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Aspergillus fumigatus,Aspergillus nidulans,Preussia australis,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens)
• NSE activates AMPK in the liver and muscles to improve glucose metabolism (2011, NA)
• Network images of FTO and candidates genes (2011, NA)
• HPV 16 E5 enhances growth factor signalling pathways (2011, NA)
• New additions to the Hippo pathway in flies (a) and man (b) (2011, Drosophila melanogaster,Homo sapiens)
• Notch canonical signalling pathway (2011, NA)
• Homeostatic and leukemic expression of receptors, signaling proteins, and transcription factors along the B cell pathway (2011, NA)
• Autophagy pathway in plants (2011, NA)
• Bevacizumab Treatment for Advanced Breast Cancer (2011, Homo sapiens)
• PI3K, AKT, FOXO, and BCL6 are key players in Ph+ stem cell survival (2011, Homo sapiens,Mus musculus,Aspergillus janus)
• G2/M transition and G2/M checkpoint induction (2011, NA)
• G1/S transition and G1/S checkpoint induction (2011, NA)
• Genes Regulating Muscle Protein Degradation (2011, Homo sapiens,Caenorhabditis elegans)
• Diagram illustrating the DNA base excision repair (BER) pathway (2011, Homo sapiens,Mus musculus)
• Activation of inflammatory mediators in pancreatic Beta-cells in type 1 diabetes (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Antarctothoa delta,Corvus corax)
• Rescue of the aged fibroblast to myofibroblast differentiation by amplification of TGFB signaling via the Tak1/AMPK/p38MAPK pathway (2011, NA)
• Roles and metabolism of glutathione (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• The genes and pathways associated with Crohn's disease pathogenesis (2011, Homo sapiens,Mus musculus)
• Schematic overview of potential links between calcium, hormonal and developmental signals and cell cycle regulators; note that the proposed scheme is not complete (2011, NA)
• Endoreduplication cycle control in plants (2011, Solanum lycopersicum,Embryophyta)
• Differential gene expression in the TLR signalling pathway (2011, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycobacterium avium,Bos taurus,Sus scrofa,Homo sapiens,Mus musculus,Sequoia sempervirens)
• Molecular pathways of oligomeric AB mediated synaptic dysfunction (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,prion)
• Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma (2011, Homo sapiens,Nicotiana tabacum,Human papillomavirus)
• p63 signaling in cancer cells (2011, NA)
• Evolution of the TGFB Signaling Pathway and Its Potential Role in the Ctenophore, Mnemiopsis leidyi (2011, NA)
• Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD (2011, NA)
• Pathway interactions and detailed network visualization for the interactions with three apoptosis related pathways for the comparison between HF and LF diet at t = 0 (2011, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• An indirect interaction between the Axon Guidance and Insulin Signaling pathways in the network for the comparison between HF and LF diet at t = 0 (2011, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Toll-like Receptor 3 Regulates Neural Stem Cell Proliferation by Modulating the Sonic Hedgehog Pathway (2011, NA)
• NUAK2: an emerging acral melanoma oncogene (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• EBV infection impacts on cell death and survival pathways in GC B cells (2011, NA)
• Fatty-acid biosynthetic pathway for R (2011, Rickettsia prowazekii,Homo sapiens)
• Functional relationship linking Crb proteins to the SWH pathway (2011, NA)
• Insights into Eyestalk Ablation Mechanism to Induce Ovarian Maturation in the Black Tiger Shrimp (2011, NA)
• Dickkopf1 Regulates Fate Decision and Drives Breast Cancer Stem Cells to Differentiation: An Experimentally Supported Mathematical Model (2011, NA)
• Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism (2011, NA)
• Elevated PI3K signaling drives multiple Breast Cancer subtypes (2011, Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Avian sarcoma virus 16,Homo sapiens)
• Role of ATR- or ATM-dependent modulation of WRN function in promoting correct recovery from replication arrest (2011, Homo sapiens,Mus musculus,Xenopus laevis,Schizosaccharomyces pombe)
• Interactions between the Ras/Raf/MEK/ERK, Ras/PI3K/PTEN/mTOR and Wnt/Beta-Catenin Pathways that Result in the Regulation of Protein Translation and Gene Transcription (2011, Homo sapiens,Mus musculus)
• Ras/PI3K/PTEN/Akt/mTOR Pathway and Potential Sites of Therapeutic Intervention (2011, Homo sapiens,Mus musculus)
• PI3K signalling pathway: The phosphatidylinositol 3-kinase (PI3K) signalling pathway begins with PI3K activation by receptor tyrosine kinases after growth factors or insulin stimulation (2011, NA)
• Ras/Raf/MEK/ERK Pathway and Potential Sites of Therapeutic Intervention with Small Molecule Membrane-Permeable Inhibitors (2011, Homo sapiens,Mus musculus)
• Maturational changes in fatty acid and carbohydrate metabolism gene expression (2011, NA)
• Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways (2011, Mus musculus,Rattus norvegicus,Meleagris gallopavo,Pandion haliaetus,Homo sapiens,Drosophila melanogaster)
• Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways (2011, Mus musculus,Rattus norvegicus,Meleagris gallopavo,Pandion haliaetus,Homo sapiens,Drosophila melanogaster)
• Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Asian population (2011, Mus musculus,Rattus norvegicus,Meleagris gallopavo,Pandion haliaetus,Homo sapiens,Drosophila melanogaster)
• Results of pathway prediction and network modeling showing interactions between genes containing SNPs associated with risk for breast cancer and genes involved in the Notch signaling and other biological pathways based on the Caucasian population (2011, Mus musculus,Rattus norvegicus,Meleagris gallopavo,Pandion haliaetus,Homo sapiens,Drosophila melanogaster)
• Germinal-center B-cell-like (GCB) diffuse large B-cell lymphoma (DLBCL) derived from normal germinal-center centroblasts (2011, NA)
• Innate immune signalling at the mitochondria (2011, NA)
• Activated B-cell-like (ABC) diffuse large B-cell lymphomas (DLBCLs) are derived from plasmablasts that are characterized by a block in differentiation (2011, NA)
• Structural and functional characteristics of the human CD38 molecule (2011, NA)
• PepMV infection of tomato affects the citrate cycle and PTGS (2011, Solanum lycopersicum,Pepino mosaic virus)
• Autism, Alzheimer disease, and fragile X (2011, NA)
• Gene expression pattern of the P38 MAPK signaling pathway (2011, Saccharomyces cerevisiae,Arabidopsis thaliana,Armoracia rusticana,Nicotiana tabacum,Diaporthe sclerotioides,Schizosaccharomyces pombe,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Bos taurus,Mouse mammary tumor virus)
• RIGI-like receptor pathway (2011, NA)
• Cellular and Molecular Action of the Mitogenic Protein-Deamidating Toxin from Pasteurella multocida (2011, NA)
• Chemokine Signaling Pathway (2011, Homo sapiens,Mus musculus)
• Cholesterol transport in the CNS (2011, NA)
• Autocrine signaling by IGF-II regulates muscle differentiation (2011, NA)
• Diagram of the proposed cell survival signaling pathway in ER+ breast cancer cells with PI3KCA mutations and low phosphorylated Akt (2011, Homo sapiens)
• Known apoptotic targets of P53 (2011, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus,Drosophila melanogaster,Eutheria)
• Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells (2011, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus,Dipturus trachyderma)
• Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells (2011, NA)
• Autophagy in macrophages (2011, NA)
• NFKB pathway activation via death receptor signaling (2011, NA)
• Fatty acid Biosynthesis (Source KEGG pathway database) (2011, NA)
• Signaling pathways regulating epithelial immune response in nematode epidermal (a) and intestinal (b) cells, adapted from Tan and Shapira (2011, NA)
• Redoxosome formation in IL-1 signaling (2011, NA)
• Uncoupling of GAi/o proteins from their cognate G protein-coupled receptor (GPCR) (2011, Escherichia coli,Pseudomonas aeruginosa,Vibrio cholerae,Pseudomonas aeruginosa BL10,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Gi/o protein-dependent and -independent effects of PTX (2011, Escherichia coli,Pseudomonas aeruginosa,Vibrio cholerae,Pseudomonas aeruginosa BL10,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• GSK3-dependent control of SV recycling in mature nerve terminals (2011, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells (2011, NA)
• RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Taxila haquinus)
• TLR-induced microbial resistance (2011, NA)
• Upstream kinases and redox-sensitive phosphatases in NFKB activation (2011, NA)
• KEGG Pathway Map () (2011, Homo sapiens)
• Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors (2011, NA)
• Activation of NFKB via the canonical pathway and putative sites for redox-regulation (2011, NA)
• Different ways to activate NFKB (2011, NA)
• Zn2+-dependent signaling in neuronal tolerance (2011, NA)
• YB-1 drives preneoplastic progression: Insight into opportunities for cancer prevention (2011, Homo sapiens,Mus musculus,clinical samples)
• Evi1 forms a bridge between the epigenetic machinery and signaling pathways (2011, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Zn2+-dependent signaling in neuronal cell death (2011, NA)
• NFKB in Aging and Disease (2011, Homo sapiens,Mus musculus)
• Proposed diagram for Alpha-mangostin-induced apoptosis in COLO 205 cells (2011, Homo sapiens)
• c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models (2011, Homo sapiens)
• Proteins encoding the CAF and tumor stroma-associated genes from seven different epithelial tumors share common involvement in the MAPK signaling pathway and focal adhesion (2011, Homo sapiens,Mus musculus)
• Conservation of the RB and Hippo signaling pathways in humans and fruit flies (2011, NA)
• Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003) (2011, NA)
• Studies on a unique organelle localization of a liver enzyme, serine:pyruvate (or alanine:glyoxylate) aminotransferase (2011, Oryctolagus cuniculus,Canis lupus familiaris,Felis catus,Homo sapiens,Mus musculus,Rattus norvegicus,Callithrix jacchus,Escherichia coli)
• Costimulatory pathways relevant in transplantation (2011, NA)
• Top network affected by MAA (2011, NA)
• AB toxicity as illustrated for the signaling through the NMDA (N-methyl d-aspartate) receptor (NMDAR) (2011, Mus musculus,Rattus norvegicus,Cricetus cricetus,Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Drosophila melanogaster,Human immunodeficiency virus 1,prion)
• Schematic diagram of the ER stress response (2011, NA)
• Simultaneous siRNA Targeting of Src and Downstream Signaling Molecules Inhibit Tumor Formation and Metastasis of a Human Model Breast Cancer Cell Line (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Human alphaherpesvirus 2,Avian sarcoma virus,Homo sapiens,Armoracia rusticana)
• Serpinin formation, its signaling pathway, and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells (2011, Mus musculus,Acanthobothrium sp. 1,Homo sapiens)
• The signaling cascade in response to the release of dsRNA from LRV particles, production of IFNB and secretion of proinflammatory cytokines and chemokines (2011, NA)
• Therapeutic Strategies to Overcome Acquired Resistance to BRAF or MEK Inhibitors in BRAF Mutant Cancers (2011, NA)
• NVN for Putative CHS-Mediated (CHS4) Medicarpin Biosynthesis.Nodes in the network resemble individual genes, and the connecting edges represent coexpressed links (2011, Arabidopsis thaliana,Glycine max)
• Metabolic Homeostasis: HDACs Take Center Stage (2011, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing (2011, NA)
• Coronin 2A-dependent LXR transrepression pathway in macrophages (2011, NA)
• Melanoma signaling networks, progression, and influences by the BCL-2 family (2011, NA)
• Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence (2011, NA)
• Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing (2011, NA)
• TRAF3-mediated positive and negative regulation of IFN signaling (2011, NA)
• BMP receptor signaling pathway (2011, NA)
• Roles of the BMP system in steroidogenesis and mitogenesis in growing follicles (2011, NA)
• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health (2011, Homo sapiens)
• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health (2011, Homo sapiens)
• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health (2011, Homo sapiens)
• The participation of MCP-1, TNFA, MMP-9, E-cadherin, and Beta-catenin in macrophage fusion (2011, NA)
• Recent Advances in Anti-Angiogenic Therapy of Cancer (2011, NA)
• Partial hepatectomy stimulates anandamide production through a pathway involving conjugation of arachidonic acid and ethanolamine by FAAH (2011, NA)
• PDP-1 Links the TGFB and IIS Pathways to Regulate Longevity, Development, and Metabolism (2011, NA)
• Innate Immune Sensing of DNA (2011, Listeria monocytogenes,Francisella tularensis,Homo sapiens,Mus musculus,Human alphaherpesvirus 1)
• Molecular modulation of peripheral myelination by the Sirt2/Par-3/aPKC pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Scheme for CCM including main pathways - glycolysis/gluconeogenesis, penthaphosphate pathway, citrate cycle, overflow pathway (2011, Escherichia coli,Homo sapiens)
• Expanded networks of transport and signaling pathways (2011, NA)
• Insulin caused drug resistance to oxaliplatin in colon cancer cell line HT29 (2011, NA)
• Personalizing Therapy with Targeted Agents in Non-Small Cell Lung Cancer (2011, NA)
• FosB-mediated regulation of ECM genes by mechanical signaling in bladder smooth muscle (2011, NA)
• Lysophosphatidic Acid Activates Peroxisome Proliferator Activated ReceptorG in CHO Cells That Over-Express Glycerol 3-Phosphate Acyltransferase-1 (2011, NA)
• Scheme of the EGR-1/GGPPS/ERK 1/2 pathway (2011, NA)
• Jun N-terminal kinase signaling pathway (2011, NA)
• The PLD signaling pathway in primary epithelial cells (2011, Rattus norvegicus,Adenoviridae,Homo sapiens)
• Post-induction repression of IFNB expression by YY1 in TLR3 signaling pathway (2011, NA)
• Leptin Signaling in Intestinal Epithelium Mediates Resistance to Enteric Infection by Entamoeba histolytica (2011, Entamoeba histolytica,Homo sapiens)
• Signal-receiving cell—modulation of developmental signalling by intracellular trafficking (2011, NA)
• FcGR stimulation-induced [Ca2+]i increase via Cx43/CD38/cADPR signaling pathway (2011, Mus musculus,Homo sapiens)
• Central prostate cancer-related processes and their miRNA-mediated regulation (2011, NA)
• PIKKs and TCR-associated pathways (2011, NA)
• Effector signaling pathways activated during ischemia preconditioning (2011, NA)
• SHP-1 activation and modulation on ghrelin signaling to Akt (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Model illustrating that early and late ISGs induction is regulated by multiple STAT1 posttranslational modifications (2011, NA)
• Multiple Smad phosphoisoforms exist (2011, NA)
• Network annotation of genes differentially expressed according to the CD133 status in HT-29 using ingenuity pathway analyses (2011, NA)
• Enhancement of HIV-1 infection as a result of HIV-1 gp41 binding to CD74 and subsequent activation of the ERK/MAPK signal pathway (2011, NA)
• Proposed signaling of TNFA− and leptin-induced EL upregulation in primary placental ECs (2011, Homo sapiens,Mus musculus)
• Different modes of Smad phosphoisoform signaling in normal epithelium and neoplasms (2011, NA)
• Proposed mechanism of homocysteine-induced inhibition of hepatic glycogen synthesis (2011, NA)
• Schematic diagram delineating the Hsp90–NFKB–Beclin1 pathway involved in the selenite-induced apoptosis and autophagy of NB4 cells (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Homo sapiens)
• Working model (2011, Bos taurus,Canis lupus familiaris,Homo sapiens,Mus musculus,Sorbus aucuparia)
• TRAIL signaling pathway and regulatory proteins (2011, Homo sapiens,Mus musculus,Malus domestica,Dipturus trachyderma)
• Cellular PA-interaction networks (2011, NA)
• Model of Egr-1/GGPPS/Erk1/2 pathway regulating insulin resistance in hyperinsulinism (2011, NA)
• FGF23 induces left ventricular hypertrophy (2011, NA)
• Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane (2011, Homo sapiens)
• The effects of apoA-I on TNFA mRNA stabilization in LPS-stimulated macrophages (2011, NA)
• GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin B Gene (2011, NA)
• Multifaceted Intervention by the Hsp90 Inhibitor Ganetespib (STA-9090) in Cancer Cells with Activated JAK/STAT Signaling (2011, NA)
• The proposed signalling pathway (2011, NA)
• Signaling pathway components used to test gene–compound interactions (2011, NA)
• Wnt/Beta-catenin signaling pathway and its small molecule inhibitors (2011, NA)
• Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hypothalamus (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus,Merluccius merluccius)
• Bioenergenesis neurotransmitter pathways with differentially expressed genes between frontal cortex and hippocampus (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Middle East respiratory syndrome-related coronavirus,Merluccius merluccius)
• Regulated fatty acid synthesis and metabolism during cell differentiation (2011, NA)
• DNA damage-triggered activation of SAPK/JNK at late times following cisplatin treatment (2011, Homo sapiens,Mus musculus)
• NFKB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28 (2011, Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Nairobi sheep disease virus,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA,NA)
• The PI3K pathway in TLR-signaling (2011, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Leishmania major,Homo sapiens,Saccharomyces cerevisiae,Porphyromonas gingivalis,Measles morbillivirus)
• Polarization of migrating cortical neurons by Rap1 and N-cadherin (2011, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Phosphatidylinositol 3-kinase (PI3K)-Akt-glycogen synthase kinase 3 (GSK3) signalling is required for expression of a subset of interleukin-10 (IL-10) inducible genes (2011, NA)
• Polarization of migrating cortical neurons by Rap1 and N-cadherin (2011, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Glycolytic pathway and moonlighting actions of bacterial glycolytic proteins (2011, Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Streptococcus pneumoniae,Streptococcus pyogenes,Homo sapiens)
• Differential Expression of MicroRNAs in Tumors from Chronically Inflamed or Genetic (APCMin/+) Models of Colon Cancer (2011, NA)
• Proposed ACE2/ANG-(1–7)/Mas signaling pathways in the central nervous system (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Profiling Insulin Like Factor 3 (INSL3) Signaling in Human Osteoblasts (2011, NA)
• Topological scheme of modeled cyclic nucleotide signaling pathways (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Raphanus sativus,Homo sapiens,unidentified)
• Effect of miR-300 on TGFB signaling pathway (2011, Homo sapiens,Mus musculus,Bos taurus,Sleeping disease virus)
• Influence of miR-300 on apoptosis pathway (2011, Homo sapiens,Mus musculus,Bos taurus,Sleeping disease virus)
• Metabolic pathways for acetyl-CoA generation in G (2011, NA)
• Models of how IFNB and GA activate PI3KD/Akt and MEK/ERK pathways to induce sIL-1Ra production in monocytes (2011, Homo sapiens)
• The mechanisms underlying the effects of BDNF on dendritic development of cortical neurons (2011, NA)
• Effect of miRNAs on cell cycle, proliferation, and differentiation (2011, Homo sapiens,Mus musculus,Bos taurus,Sleeping disease virus)
• Summary of the modes of action of selected small molecules that modulate morphogenesis in Candida albicans (2011, NA)
• Pathogenesis of neurodegenerative diseases is significantly associated with oxidative stress (2011, NA)
• From a physiological point of view, exfoliated epithelial cells resulting from nutritional induction or mild stress are in anoikis by activating a survival mechanism partly using the molecular paths of macroautophagy (2011, NA)
• Regulation of MAPK and NFKB pathways and their manipulation by bacterial effectors (2011, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Porphyromonas gingivalis,Bacillus anthracis,Shigella flexneri,Mycobacterium tuberculosis variant bovis,Neisseria gonorrhoeae,Escherichia coli O157H7,Vibrio parahaemolyticus,Yersinia pseudotuberculosis,Shigella sonnei,Aeromonas salmonicida,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Corynebacterium phage gamma)
• Pathways that modulate canonical Wnt signaling (2011, NA)
• Breaking up is hard to do (2011, NA)
• Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus caballus,Gallus gallus,Coturnix coturnix,Merluccius merluccius,Homo sapiens,Mus musculus)
• Insights into the Pathogenesis and Treatment of Cancer from Inborn Errors of Metabolism (2011, Homo sapiens)
• Targeted Morphoproteomic Profiling of Ewing's Sarcoma Treated with Insulin-Like Growth Factor 1 Receptor (IGF1R) Inhibitors: Response/Resistance Signatures (2011, Homo sapiens,Dipturus trachyderma)
• Changes in mRNA levels among various signalling pathway members following inhibition of FGFR activity (2011, NA)
• Schematic illustrating the potential role of integrin B3 (ITGB3) in ROS-induced migration and invasion of colorectal cancer cells (2011, Homo sapiens)
• Genes mapping to KEGG pathway for hedgehog signaling (2011, NA)
• Genes mapping to KEGG pathway for phosphatidylinositol signaling system (2011, NA)
• Temporal Order of Genetic and Pathway Alterations in Tumorigenesis (2011, Homo sapiens)
• Synaptic translation and signaling pathways modulated by FMRP (a) and dysregulation of these pathways in the absence or significant reduction of FMRP (b) (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Agaricus bisporus)
• One of experimental result from pathways intersection (2011, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Mycobacterium tuberculosis,Mouse mammary tumor virus)
• One experimental result of identified pathways from ovarian expression data (2011, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Mycobacterium tuberculosis,Mouse mammary tumor virus)
• Schematic analysis of the regulatory pathways in BOO in AROM+/6J male mice (2011, NA)
• Signaling modules identified by correlational analysis of end points (2011, NA)
• Endothelial growth factor receptor (EGFR) signaling pathway (2011, NA)
• Vascular endothelial growth factor (VEGF) signaling pathway (2011, NA)
• Targeted treatments for fragile X syndrome (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Agaricus bisporus)
• Biological actions of IGF-1 are mediated by IGF-1R and modulated by IGFBPs (2011, Mus musculus,Homo sapiens)
• The EGR-1/GGPPS/Erk1/2 pathway in the promotion of the inflammatory response during cigarette smoke exposure (2011, NA)
• Regulation of Atm pathway genes after Rif-Phen-MCT (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Vicious cycle of bone metastases in the osteoblastic pathway, in which tumor cells secrete other factors (interleukins, prostaglandin e, tumor necrosis factor, and macrophage-stimulating factor) (2011, Homo sapiens)
• Potential routes of PARP-1 stimulation of inflammatory gene expression (2011, NA)
• Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy (2011, NA)
• STRING interaction for proteins studied to find relevant networks in RCC (2011, Homo sapiens,Mus musculus)
• Proposed signaling pathway for G2A-mediated enhancement of apoptotic cell engulfment (2011, NA)
• Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells (2011, NA)
• CAERUS: Predicting CAncER oUtcomeS Using Relationship between Protein Structural Information, Protein Networks, Gene Expression Data, and Mutation Data (2011, Homo sapiens,Nicotiana tabacum)
• Structural coverage of the core vision pathway and its links to other functional modules (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Hordeum vulgare,Homo sapiens)
• TGFB signaling pathway (2011, Homo sapiens,Mus musculus,Bikinia letestui)
• MAPkinase signalling (2011, Homo sapiens,Mus musculus,Bikinia letestui)
• Melanoma Molecular Disease Model (2011, Homo sapiens,Mus musculus)
• Schematic overview of the network of enriched pathways related to HIV disease progression (2011, NA)
• Branches of MAPK pathway significantly enriched in CD4+ T cells from the LTNP group (BDL versus LTNP) (2011, NA)
• Coordinately up-regulated cell cycle genes in CD8+ T cells from the VIR group (VIR versus BDL) illustrated in cell cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) (2011, NA)
• Coordinately up-regulated TCA cycle genes in CD8+ T cells from the VIR group (VIR versus LTNP) illustrated in TCA cycle pathway from Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/) (2011, NA)
• Schematic representation depicting the mode of action of angiogenin in maintaining latency (2011, NA)
• Metabolic disturbance and pathway activation in the Acsl1T−/− heart (2011, Mus musculus,Homo sapiens)
• ROCK signaling pathway with focus on survival and regeneration (2011, NA)
• Hypoxia inducible factor (HIF) pathway (2011, Homo sapiens,Mus musculus)
• Glycosyltransferase complexes in the O-glycosylation pathway (2011, NA)
• Model: TTP transition from “hypo- to hypermodified” determines its functional switch (2011, NA)
• Cannonical pro-fibrotic TGFB signaling is initiated by the binding of active TGFB to TGFB receptors (2011, NA)
• Network of differentially expressed genes in transgenics at 12 months (parametric and nonparametric approaches) (2011, NA)
• Network of differentially expressed genes in HMGA1 transgenics at 12 months (parametric approach) (2011, NA)
• Network of differentially expressed genes in HMGA1 transgenics at 12 months (nonparametric approach) (2011, NA)
• IPA-based pathway analysis of differential expressed genes (2011, Homo sapiens,Mus musculus)
• Integrated Transcriptome and Binding Sites Analysis Implicates E2F in the Regulation of Self-Renewal in Human Pluripotent Stem Cells (2011, NA)
• Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome (2011, NA)
• Network of differentially expressed genes in transgenics at 2 months (parametric and nonparametric approaches) (2011, NA)
• Schematic presentation of Nag PTS and parts of the central metabolism of R (2011, NA)
• Network of differentially expressed genes in HMGA1 transgenics at 2 months (parametric approach) (2011, NA)
• Genome-Wide Identification of Bcl11b Gene Targets Reveals Role in Brain-Derived Neurotrophic Factor Signaling (2011, Bos taurus,Oryctolagus cuniculus,Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• Expression patterns of the TLR signaling pathway in CLL (2011, Homo sapiens)
• Iron in regulating the mTOR signaling pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Network of differentially expressed genes in HMGA1 transgenics at 2 months (nonparametric CAM approach) (2011, NA)
• Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development (2011, NA)
• Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map (2011, NA)
• Advanced Computational Biology Methods Identify Molecular Switches for Malignancy in an EGF Mouse Model of Liver Cancer (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Biochemical pathways and enzymes involved in carbon and nitrogen metabolism in Cyanothece ATCC51142 (2011, NA)
• Hypothetical sequence of the pathogenic steps of the Alzheimer mitochondrial cascade hypothesis (2011, NA)
• Proposed schematic presentation of SiO2NP-induced stress response signalling pathway (2011, NA)
• The multiple mechanisms by which Sox2 regulates the osteoblast lineage (2011, NA)
• BRCA2/RAD51 pathway in the response to stalled forks (2011, NA)
• BRCA2/RAD51 pathway in response to DSBs (2011, NA)
• IA30-infected pigs fail to induce immune response genes associated with pattern recognition of viruses and cytokine and immune cell responses in the lung (2011, Influenza A virus,Orthomyxoviridae,H1N1 subtype,Swine influenza virus,Homo sapiens,Sus scrofa)
• Worker Honeybee Fat Body Proteome Is Extensively Remodeled Preceding a Major Life-History Transition (2011, Drosophila melanogaster,Caenorhabditis elegans,Apis mellifera,Anopheles aquasalis,Rhyparobia maderae,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Paenibacillus larvae,Deformed wing virus)
• Canonical Wnt/Beta-catenin signaling (2011, NA)
• Proposed signal transduction pathways in NG following receptor activation with leptin and CCK-8 (2011, NA)
• Protein interaction pathway produced by combining known protein–protein interactions from the literature (2011, NA)
• Signaling pathways and proteins that increase or decrease STAT5 signaling in normal mammary epithelial cells (2011, NA)
• Nitric oxide-activated AMPK activation in B cells (2011, NA)
• Simplified cartoon of PRR signaling in epithelial cells showing only the canonical pathway of NFKB activation and some of the key receptors, adaptors, and kinases involved (2011, Mus musculus,Homo sapiens)
• Synthesis, utilization, and regeneration of glutathione and regulation of mTORC1 activity (2011, Human betaherpesvirus 5)
• Schematic showing the mechanism(s) of activation of the NLRP3 inflammasome and NFKB signaling pathways by vMyxM013-KO virus infection in human monocytic cell line THP-1 (2011, NA)
• Schematic presentation showing leptin mediated signaling pathways (2011, NA)
• mTOR signaling pathway affected by pollen feeding or varroa parasitism (2011, NA)
• Simplified diagram showing some of the identified BCR pathway members (2011, NA)
• Corticotropin Releasing Factor-Induced CREB Activation in Striatal Neurons Occurs via a Novel GBG Signaling Pathway (2011, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Microtus ochrogaster,Homo sapiens)
• Evasion of immune responses by individual EBV products (2011, NA)
• Elicitation of innate immune response in EBV infection (2011, NA)
• Schematic of C/EBP A/B functions in GCs (2011, NA)
• Schematic overview of the RhoGDIAlpha-mediated balance between RhoA and RhoC, resulting in modifications of the signaling pathway and leading to cancer cell growth and migration (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Equus asinus,Armoracia rusticana,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Hathewaya limosa)
• Schematic model depicting the proposed signaling pathway in LH/hCG-induced LHR mRNA down-regulation (2011, NA)
• Zinc Transporter SLC39A14/ZIP14 Controls G-Protein Coupled Receptor-Mediated Signaling Required for Systemic Growth (2011, NA)
• Cyclin D1 action and degradation (2011, NA)
• MTOR signaling pathways (2011, Saccharomyces cerevisiae,Cannabis sativa,Dryobalanops aromatica,Mus musculus,Rattus norvegicus,Homo sapiens)
• The balance between Cdc42 and RasGRF pathways (2011, NA)
• IL1B Induced Smad 7 Negatively Regulates Gastrin Expression (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori,vectors,Moloney murine leukemia virus)
• Networks most highly represented by transcripts differentially associated with HuR after IR treatment (2011, NA)
• Schematic outline of the elimination of apoptotic tissue from the sponge S (2011, Suberites domuncula,Homo sapiens)
• EGFR signaling pathway (2011, Homo sapiens)
• Topography and signaling pathways triggered by selectin ligands in neutrophils (2011, Homo sapiens,Mus musculus)
• Growth factors mediated mTORC1 and mTORC2 activation (2011, NA)
• Synthesis began with a straightforward sequence that produced 56 from 44 (), in turn available from glucose in 3 steps (2011, Homo sapiens)
• How GSK3B phosphorylation is involved with microtubule destabilization (2011, Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Homo sapiens)
• Schematic diagram illustrating reciprocal regulation between iNOS and Cx43 under inflammatory situations (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mi-2/NuRD complex depletion in germinal center B cells leads to alterations in chromatin, checkpoint activation, and delayed progression through S phase (2011, Homo sapiens,Mus musculus,Bos taurus,Arabidopsis thaliana,Xenopus laevis)
• Canonical and alternate modes of action of TZDs (2011, Homo sapiens,Mus musculus)
• 100 frequent associations obtained after p value cut off in MCL with CDCOCA (2011, Homo sapiens)
• KEAP1 Cullin-3 E3-ubiquitin ligase complex and its roles in maintaining cellular levels of NRF2 and IKBKB (2011, Homo sapiens,Mus musculus,Capra hircus,Sequoia sempervirens)
• Proposed resveratrol-mediated regulation of p35 expression and Cdk5 activity (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Vitis vinifera)
• Simple schema of the IGF pathway and approaches to its inhibition (2011, NA)
• Molecular and cellular alterations involved in neuronal dysfunction in Alzheimer's disease (AD) (2011, NA)
• Negative regulation of the IMD pathway (2011, NA)
• Notch-2 Gene Is Regulated by Wnt Signaling in Cultured Colorectal Cancer Cells (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Drosophila melanogaster,Trypeta flaveola,Homo sapiens,Mus musculus,Xenopus laevis,Human gammaherpesvirus 4,vectors)
• Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses (2011, NA)
• Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses (2011, NA)
• The P2X7 Receptor in Infectious Diseases (2011, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Streptococcus pneumoniae,Vibrio cholerae,Chlamydia trachomatis,Francisella tularensis,Legionella pneumophila,Brucella abortus,Chlamydia psittaci,Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Leishmania major,Leishmania donovani,Cryptosporidium parvum,Leishmania amazonensis,Theileria parva,Toxoplasma gondii ME49,Tritrichomonas foetus,Homo sapiens,Mus musculus,Bos taurus)
• Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Insulin has two signaling pathways within the insulin-sensitive cell: one that uses the PI-3 pathway regulates metabolic activity, and the other that uses the MAP kinase regulates mitogenic activity (2011, Homo sapiens,Diaporthe sclerotioides)
• Insulin resistance in obesity and type 2 diabetes occurs because of a block in the transmission of the insulin signal through PI-3 kinase (2011, Homo sapiens,Diaporthe sclerotioides)
• Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling (2011, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Caenorhabditis elegans)
• Runx2-deficient cells exhibit suppression of genes by insulin at multiple stages of the signaling pathway (2011, NA)
• Decorin’s effects on Beta-catenin and Myc stabilization by directly down-regulating EGFR and Met (2011, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus,Drosophila melanogaster,Danio rerio,Citrus macrophylla)
• ‘Integrative Physiology 2.0’: integration of systems biology into physiology and its application to cardiovascular homeostasis (2011, NA)
• RPA/9-1-1- and hMSH2-mediated ATR activation in DNA damage signaling (2011, Homo sapiens,Mus musculus)
• Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice (2011, NA)
• Schematic illustration of signalling within the type I interferon (IFN) system (2011, NA)
• Knowledge-based pathway analysis (Genomatix BiblioSphere Software) indicating the network of high BMI-associated genes (2011, NA)
• Identification of Biochemical Network Modules Based on Shortest Retroactive Distances (2011, Homo sapiens,Saccharomyces cerevisiae)
• Principal signaling pathways involved in plasmalemmal TRPM8 regulation (2011, NA)
• Possible mechanism of reciprocal enhancement between innate and adaptive immunity, through NF-kB and STAT-1/IRF-1 pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Chlamydia trachomatis,Vaccinia virus GLV-1h68,NA)
• Possible role of RACK1 in VEGF/Flt1-induced cell migration (2011, NA)
• Working Model for the Late-Acting Function of NFU1 in Mitochondrial Fe-S Protein BiogenesisThe findings of this work suggest a late-acting function of NFU1 in the pathway of Fe-S (red and yellow circles) protein maturation (2011, Homo sapiens,Saccharomyces cerevisiae)
• Appearance frequencies of genes in the mTOR signaling pathway (2011, NA)
• Normal (A) and pathological (B) integrin-based focal adhesion signaling (2011, NA)
• Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis (2011, Mus musculus,Cricetus cricetus,Homo sapiens,unidentified)
• Hypothetical diaphragm of HS7 induced apoptosis and inhibition of Wnt/Beta-catenin signaling pathway in HT-29 colon cancer cells (2011, NA)
• Nongenomic signaling of aldosterone in mouse OMCD intercalated cells to stimulate H+-ATPase activity (2011, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Proposed signal pathway by which repetitive deformation may induce intestinal epithelial cell migration (2011, NA)
• miR451 and AMPK Mutual Antagonism in Glioma Cell Migration and Proliferation: A Mathematical Model (2011, NA)
• Regulation of cardiac hypertrophy by AKAP complexes (2011, NA)
• Top associated network functions for miR-141 and miR-200c (2011, NA)
• Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds (2011, Camellia sinensis,Homo sapiens)
• Wnt/Beta-catenin signalling in the absence and presence of Wnt stimulus (2011, Homo sapiens)
• HCMV promotes GBM pathogenesis (2011, NA)
• DNA-mediated activation of innate immune signaling (2011, NA)
• Further implications of G-/GM-CSF-induced JAK-STAT signaling in peripheral sensory neurons (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Complement system: the classical complement pathway involves a sequentially acting multistep cascade in which the complement components C1q, C1s, C1r, C4, C2, and C3 play important roles (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• modified from : Tryptophan is an essential amino acid and a precursor for the synthesis of serotonin (2011, NA)
• Schematic overview of CagL and CagA-mediated signal transduction pathways involved in H (2011, NA)
• Summary by schematic illustration (2011, Mus musculus,Homo sapiens)
• Wnt1/Fzd-1/Beta-catenin signaling as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk (2011, Mus musculus,Mouse mammary tumor virus,Homo sapiens)
• CRF1 receptor as the regulator of skin cells functions (2011, NA)
• Resulting endoplasmic reticulum (ER) stress and unfolded protein response (UPR) gene network from a modelling approach using the set of differentially regulated genes common to all pancreatic cancer cell lines after nemorosone treatment (2011, NA)
• Schematic Models of Tap46/Tap42/A4 Functions in TOR Signaling Pathways in Eukaryotes.(A) TOR signaling in yeast (2011, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Homo sapiens)
• TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock (2011, NA)
• Activation signals for effector and regulatory T-cell division and proliferation (2011, Homo sapiens,Mus musculus)
• Drug Inhibition Profile Prediction for NFKB Pathway in Multiple Myeloma (2011, NA)
• Drug Inhibition Profile Prediction for NFKB Pathway in Multiple Myeloma (2011, NA)
• Non-genomic ERA pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Mouse mammary tumor virus)
• Endometrial androgen target gene set (2011, NA)
• Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis (2011, NA)
• Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection – A Meta-Analysis of Genomic Signatures in Circulating Leukocytes (2011, Influenza A virus,unidentified influenza virus,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza A virus H3N2,Homo sapiens,Mus musculus,Sus scrofa)
• Norepinephrine (NE)/p38 mitogen-activated protein kinase (MAPK) signalling in T-lineage cells (2011, NA)
• MAPK pathway activation in melanoma (2011, Homo sapiens,Mus musculus)
• Regulation of epidermal homeostasis by PCP signaling (2011, NA)
• ARV entry and signal pathways involved in this process (2011, NA)
• Schematic presentation of the signaling pathway involved in histamine-induced up-regulation of H1R mRNA expression in HeLa cells (2011, NA)
• Oncostatin M signaling pathway (2011, Homo sapiens)
• The Nrf2 pathway in PD pathogenesis (2011, Allium sativum,Zingiber officinale,Cinnamomum verum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Cardiovascular disease genes increase in the spleen of CVB3 infected males at 12 h pi (2011, Coxsackievirus B3,Coxsackievirus,Homo sapiens,Mus musculus)
• Endocrine system development and function genes increase in the spleen of CVB3 infected males at 12 h pi (2011, Coxsackievirus B3,Coxsackievirus,Homo sapiens,Mus musculus)
• Domain organization of DARPP-32 (2011, NA)
• Hsp72 is an important intracellular protein to inhibition of HMGB1 release and proinflammatory function in macrophages () (2011, NA)
• Hsp72 regulates oxidative stress-induced HMGB1 cytoplasmic translocation and release (2011, NA)
• Signaling pathway of HMGB1-mediated ischemia reperfusion injury (2011, NA)
• Summary of the detrimental effects of TNFA on both neuronal and glial cells during cerebral ischemia (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins (2011, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Dengue virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Human T-cell leukemia virus type I,West Nile virus,Measles morbillivirus,Encephalomyocarditis virus,Murine leukemia virus,ssRNA viruses,Bovine viral diarrhea virus 1,Mengo virus,Human foamy virus,Homo sapiens,Macaca mulatta,Plasmodium falciparum,Toxoplasma gondii,Mus musculus,Bos taurus,NA,NA)
• Molecular mechanisms through the Epidermal Growth Factor Receptor pathway (2011, Homo sapiens)
• The AKAP-Lbc·p38A activation complex (2011, NA)
• Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,H1N1 subtype)
• Training Signaling Pathway Maps to Biochemical Data with Constrained Fuzzy Logic: Quantitative Analysis of Liver Cell Responses to Inflammatory Stimuli (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,H1N1 subtype)
• Summary of TNFR signalling (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• Noncanonical Notch signaling pathway (2011, NA)
• Predicting the Physiological Role of Circadian Metabolic Regulation in the Green Alga Chlamydomonas reinhardtii (2011, NA)
• RECK pathway in stromal–epithelial interaction in prostate cancer (2011, NA)
• The p14-p53-p21 and p16-Rb signaling pathways involved in fibroblast senescence (2011, NA)
• Schematic diagram showing the signaling pathways in the CD40-induced ROS production (2011, Homo sapiens)
• Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice (2011, NA)
• Suggested modes of the involvement of Nrf2/ARE in the regulation of AML cell differentiation (2011, NA)
• Metformin inhibits hypoxia-induced HIF-1A protein expression through the inhibition of mitochondrial respiration (2011, NA)
• RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it (2011, NA)
• Signaling pathways involved in synaptic plasticity and neuroglia functions with associated molecules and cellular tasks (analysis based on Ingenuity IPA software) (2011, NA)
• Schematic drawings of GABAB receptor (GABABR)–mediated synthesis of IP3 and intracellular Ca2+signaling under (A) basal or (B) Gq-coupled receptor activation in human airway smooth muscle (2011, Homo sapiens,Cavia porcellus)
• Proposed working model and protein–protein interaction map (2011, NA)
• Network of genes commonly regulated after pioglitazone treatment (2011, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Armoracia rusticana,Helicobacter pylori)
• Interactions occuring in the ovarian mural granulosa cells (GC) and cumulus cells (CC) after the administration of hCG for ovulation induction (2011, NA)
• NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs (2011, NA)
• TLR signaling pathways (2011, Measles morbillivirus,Coxsackievirus B3,Encephalomyocarditis virus,Coxsackievirus,Coxsackievirus B4,Escherichia coli,Staphylococcus aureus,Porphyromonas gingivalis,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Trypanosoma cruzi,Homo sapiens,Gallus gallus,synthetic construct)
• Interaction between Jak2/Stat5 signaling and the PI3K/Akt1 pathway in mammary epithelial cells (2011, Homo sapiens,Mus musculus,Bos taurus,Mouse mammary tumor virus)
• Notch, Wnt, and Hedgehog signaling pathways regulate normal and stem cell fate (2011, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus,Paraechinus aethiopicus)
• CGMP signaling pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens)
• P60TRP signalling based on the results obtained from different systems including NSCs, PC12 cells and p60TRP transgenic mice (2011, NA)
• S6K1 and 4E-BP1 Are Independent Regulated and Control Cellular Growth in Bladder Cancer (2011, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Diagram represents the molecular cross-talk between TLR2 heterodimers with TLR6/TLR1 and GR through the participation of PI3K (2011, NA)
• Activation of Wnt5/Calmodulin Signalling Pathway (2011, Homo sapiens,Bos taurus,Drosophila melanogaster,Malus domestica,Molva molva)
• Tissue‐specific regulation of polyol pathway and its metabolic cascade to diabetic neuropathy (2011, Mus musculus,Rattus norvegicus,Castor fiber,Bos taurus,Osphranter robustus,Homo sapiens,Corynephage beta)
• Schematic Rac1 signalling pathway leading to cardiomyocyte TNFA expression and cardiac dysfunction during LPS stimulation (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Diaporthe sclerotioides)
• Multifunctionality of ARC in regulating apoptosis signalling (2011, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens)
• Summary of pathogenetic mechanisms of diabetic neuropathy (2011, Mus musculus,Rattus norvegicus,Castor fiber,Bos taurus,Osphranter robustus,Homo sapiens,Corynephage beta)
• Proteomic Signatures of Human Oral Epithelial Cells in HIV-Infected Subjects (2011, NA)
• Parkinson's disease pathway from the KEGG disease database (2011, Escherichia coli,Rickettsia prowazekii,Pyrococcus abyssi,Lyssavirus rabies,Lyssavirus mokola,Homo sapiens,Plasmodium falciparum)
• Arachidonic acid metabolic pathways and the role of IL-13 (2011, Mus musculus,Rattus norvegicus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Respiratory syncytial virus,Aspergillus fumigatus)
• Spry2 and Spry2Y55F function in the context of EC MAPK signaling (2011, Homo sapiens,Mus musculus)
• Schematic summary of the proposed mechanism for TGF-Beta-mediated regulation of oxidant/antioxidant balance and IL-6 release in ASMCs (2011, Mus musculus,Rattus norvegicus,Armoracia rusticana,Matthiola incana,Homo sapiens,Oryctolagus cuniculus)
• TGFB pathway in NetSlim (2011, Homo sapiens)
• Proteins of signaling pathways activated by ET-1 are targets for O-GlcNAc (2011, NA)
• Signaling pathways activated by endothelin-1 (ET-1) in vascular smooth muscle cells (VSMC) (2011, NA)
• Model explaining how RSV may mediate energy homeostasis and lifespan expansion in Ppt1-KO mice (2011, Homo sapiens,Mus musculus)
• Strain-induced migration in intestinal epithelial cells (2011, NA)
• Proposed mechanisms of ROS-dependent CO-mediated survival pathway in brain endothelial cells stimulated by TNFA (2011, NA)
• Simplified model for the intersection of signaling pathways regulating protein synthesis and degradation (2011, NA)
• Development of thrombotic microangiopathy with loss of normal complement regulatory factor function (2011, NA)
• Signalling between p53 and the IGF-AKT-mTORC1 pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Inflammation in the gouty joint (2011, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Bacillus anthracis,Shigella flexneri,Mycobacterium marinum,Influenza A virus,unidentified influenza virus,Vaccinia virus,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Candida albicans,NA)
• Noncanonical NFKB signalling (2011, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Human gammaherpesvirus 4)
• Bacterial manipulation of host pro-survival pathway (2011, NA)
• Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach (2011, Homo sapiens,Drosophila melanogaster)
• Network pathway analysis of up-regulated genes in the gene category immune response (2011, Homo sapiens,Mus musculus)
• Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach (2011, Homo sapiens,Drosophila melanogaster)
• Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach (2011, Homo sapiens,Drosophila melanogaster)
• Network pathway analysis of down-regulated genes in the gene category mitotic cell cycle (2011, Homo sapiens,Mus musculus)
• Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach (2011, Homo sapiens,Drosophila melanogaster)
• Pathway generated by ingenuity pathway analysis with proteins identified as specific target antigens (2011, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Sequoia sempervirens,Homo sapiens,Betapolyomavirus macacae)
• P53/MDM2 regulation (2011, NA)
• Sprouty2 and Spred1-2 Proteins Inhibit the Activation of the ERK Pathway Elicited by Cyclopentenone Prostanoids (2011, NA)
• Models of Wnt11 signaling and of cell proliferation and competition in the developing mouse kidney (2011, NA)
• VHL complex targets HIF-1A and HIF-2A for ubiquitin-mediated degradation (2011, Homo sapiens,Mus musculus)
• FLCN pathway (2011, Homo sapiens,Mus musculus)
• Cross-talk among embryonic signaling pathways and experimental inhibitors (2011, Homo sapiens,Mus musculus)
• Wnt signaling pathway (2011, Homo sapiens,Canis lupus familiaris)
• EGFR signaling pathway (2011, Homo sapiens)
• EBPR metabolic map inferred from the Accumulibacter clade IIA genome, adapted from ) (2011, Escherichia coli,Bacillus subtilis,Bacillus subtilis At2,Candidatus Accumulibacter phosphatis,Defluviicoccus vanus,Candidatus Competibacter phosphatis,Candidatus Accumulibacter regalis,metagenome,environmental samples,activated sludge metagenome,Homo sapiens,Bacteriophage sp.)
• The role of HLTF in remodeling protein-covered stalled replication forks (2011, NA)
• Proposed Atg1/myosin/Atg9 signalling pathway (2011, Saccharomyces cerevisiae,Homo sapiens)
• Antibodies against CD20 or B-Cell Receptor Induce Similar Transcription Patterns in Human Lymphoma Cell Lines (2011, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Human gammaherpesvirus 4)
• Embryonic pathway signaling leads to induction of epithelial-to-mesenchymal transition (2011, Homo sapiens,Mus musculus)
• Putative mechanism of dexmedetomidine (Dex) renoprotection (2011, NA)
• Modified Fearson and Volgenstein Model (2011, Homo sapiens,clinical samples)
• HRS cell and its cellular microenvironment (2011, Homo sapiens,Arachis hypogaea)
• Signal Transduction Pathways controlled by the activation of epidermal growth factor receptors (EGFR) (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Regulation of apoptosis by the BCL-2 family (2011, NA)
• Bacterial manipulation of mitochondrial cell death pathways (2011, NA)
• Crosstalk between Nuclear Factor I-C and Transforming Growth FactorB1 Signaling Regulates Odontoblast Differentiation and Homeostasis (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,vectors)
• Proposed signaling mechanisms underlying the protective effects of mood stabilizing drugs against experimental stroke (2011, NA)
• Gene Expression Profiling of Vasoregression in the Retina—Involvement of Microglial Cells (2011, NA)
• Regulatory Processes Linked to PL Metabolism (2011, Saccharomyces cerevisiae,Arabidopsis thaliana,Capsicum annuum,Aspergillus oryzae,Capsicum frutescens,Penicillium chrysogenum,Acer pseudoplatanus,Penicillium camemberti,Thermomyces lanuginosus,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Escherichia coli K-12,Trypanosoma cruzi,Trypanosoma brucei,Serratia marcescens,Yersinia enterocolitica,Tetrahymena thermophila,Glossina morsitans,Sodalis glossinidius,Serratia liquefaciens,Dolichovespula maculata,Serratia sp. MK1,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Homo sapiens,Bos taurus)
• SRC-3Δ4 isoform acts a signaling adaptor for EGF-dependent cancer cell migration and invasion (2011, NA)
• Nox regulation of the PI3K/AKT pathway (2011, Homo sapiens,Mus musculus,Danio rerio,Human gammaherpesvirus 4)
• Inhibitory pathways in innate cells utilizing ITIM or “inhibitory” ITAM signaling pathways (2011, NA)
• Context-dependent regulation of Rho GTPase signaling (2011, NA)
• Cytoplasmic tyrosine kinases in the activating signaling pathways utilizing ITAM-containing adapters (2011, NA)
• Organellar Ca2+ buffering and intracellular Ca2+ dynamics (2011, Mus musculus,Homo sapiens)
• Small-molecule inhibitors in the ubiquitin–proteasome system (UPS) (2011, NA)
• Mechanistic pathways implicated in the human studies of ventilator-induced diaphragmatic dysfunction in critically ill patients (2011, NA)
• Rad6B/Beta-catenin regulation in breast cancer cells with autocrine Wnt activity (2011, NA)
• Metabolic features of C (2011, NA)
• MicroRNAs Modulate the Dynamics of the NFKB Signaling Pathway (2011, Homo sapiens,Mus musculus,Helicobacter pylori)
• Mpk1-driven FKS2 transcription (2011, Saccharomyces cerevisiae,Homo sapiens)
• NFKB Inducing Kinase, NIK Mediates Cigarette Smoke/TNFAlpha-Induced Histone Acetylation and Inflammation through Differential Activation of IKKs (2011, Bos taurus,Oryctolagus cuniculus,Nicotiana tabacum,Capra hircus,Diaporthe sclerotioides,Phleum pratense,Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• mTOR signaling pathway The scheme depicts mTOR signaling cascade in the regulation of energy and growth factor-dependent translation and autophagy (2011, NA)
• Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts (2011, NA)
• Enrichment of fixed SNPs and Indels in an extended Notch pathway (2011, Drosophila melanogaster,Homo sapiens)
• Change in RAF isoform usage in response to a RAS mutation (2011, NA)
• Crucial role of EGF signalling augments healthy lifespan in worms (2011, NA)
• BCR, NFKB, and PI3K/AKT/mTOR deregulation in MCL (2011, NA)
• Cyclin D1, at the center of MCL pathogenesis (2011, NA)
• The CO2 Concentrating and Photorespiratory Pathways in the C3-C4 Intermediate Species F (2011, NA)
• Insulin-like growth factor type I (IGF-1R) signaling axis (2011, NA)
• Model depicting COUP-TFII functions in tumor angiogenesis (2011, Mus musculus,Gallus gallus,Homo sapiens)
• Model showing arterial, venous, and lymphatic cell fate specification in the developing embryos (2011, Mus musculus,Gallus gallus,Homo sapiens)
• Phosphatidylinositol 3-kinase signaling pathway (2011, NA)
• Predicted synthetic lethal gene pairs in TCA cycle (A), phosphatidylserine biosynthesis (B) and pentose-phosphate pathway (C) (2011, NA)
• MicroRNAs Modulate the Dynamics of the NFKB Signaling Pathway (2011, Homo sapiens,Mus musculus,Helicobacter pylori)
• Lymphotoxin and the immediate tumor necrosis factor (TNF) family (2011, NA)
• Local Proinflammatory Signalling Loop Facilitates Adverse Age-Associated Arterial Remodeling (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Celithemis elisa)
• Dietary factors, one-carbon metabolism, methionine cycle in DNA methylation (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Danio rerio,clinical samples)
• Graphical representation of the genomic neighborhoods of SRF and ZNF350 (2011, Homo sapiens,Mus musculus)
• Hypothetical network based on differentially expressed transcription factors and DEmiRNAs (2011, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Escherichia coli,Zea mays,Diaporthe sclerotioides,Helicobacter pylori,Escherichia coli 27A,Homo sapiens,Mus musculus)
• Pathways involved in platelet hyperreactivity in DM patients and therapeutic targets (2011, NA)
• Effect of carbon exchange and reversibility constraints (2011, NA)
• Integrated view of Wnt pathway (2011, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Escherichia coli,Zea mays,Diaporthe sclerotioides,Helicobacter pylori,Escherichia coli 27A,Homo sapiens,Mus musculus)
• Synthetic view of the p53 pathway (2011, NA)
• Role of GPx-1 in modulating apoptosis (2011, NA)
• Ad signaling in endothelial cells (2011, Homo sapiens)
• Activity-dependent gene expression in neurons is regulated by distinct calcium signaling pathways (2011, NA)
• ER quality control system (2011, NA)
• Schematic model in which FGF2 stimulation of osteoblast differentiation is partially through modulation of the Wnt/Beta-catenin pathway (2011, Mus musculus,Homo sapiens)
• Phosphoinositide-signaling pathway at the plasma membrane (PM) (2011, Saccharomyces cerevisiae,Homo sapiens)
• Insulin-like growth factor 1 receptor (IGF-1R) signaling pathway (2011, NA)
• Intricate network of TLR signaling and miRNAs (2011, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,Vesicular stomatitis virus,Human spumaretrovirus,Homo sapiens,Mus musculus,Nicotiana tabacum,Helicobacter pylori,Cryptosporidium parvum,NA)
• Upstream and downstream AMPK signaling pathways that negatively regulate NFKB activation and suppress inflammatory responses (2011, Mus musculus,Homo sapiens)
• Simplified schematic illustrating molecular mechanisms of neurite regulation (2011, Homo sapiens,Drosophila melanogaster,Agaricus bisporus)
• Mir-35 family function during cell cycle (2011, NA)
• Proteins interacting at the FSHR and their role in signaling (2011, NA)
• PI3K/mTOR signaling at the FSHR (2011, NA)
• Canonical GAs/cAMP/PKA pathway at the FSHR (2011, NA)
• Putative model integrating lipid peroxidation, phospholipids turnover, AA signaling, and SZ symptomatology (2011, NA)
• Multiple transduction mechanisms induced at the FSHR (2011, NA)
• Wnt signaling and the evolution of a functional gut (2011, NA)
• Simplified schematic representation of the link between LPS-induced microglial activation, inflammatory mediators, and dopaminergic neurodegeneration (2011, NA)
• Hypothetical scheme for bacteria-regulated intestinal stem cells and tumorigenesis (2011, Pseudomonas aeruginosa,Helicobacter pylori,Bacteroides fragilis,Citrobacter rodentium,Serratia marcescens,Pectobacterium carotovorum,Pseudomonas entomophila,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Wnt pathway and its regulation of Beta-catenin in stem cells and cancer (2011, Pseudomonas aeruginosa,Helicobacter pylori,Bacteroides fragilis,Citrobacter rodentium,Serratia marcescens,Pectobacterium carotovorum,Pseudomonas entomophila,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Proposed model (2011, NA)
• Impact of miR-215 on cell proliferation, cell cycle, chemoresistance, and EMT (2011, NA)
• Mechanisms of action of neuroprotective agents that are in clinical trials (2011, NA)
• Insulin Receptor-Mediated Signaling via Phospholipase CG Regulates Growth and Differentiation in Drosophila (2011, Homo sapiens,Drosophila melanogaster,Matthiola incana,Corynebacterium phage gamma)
• Novel functions of MICAL proteins (2011, NA)
• Control of Rho1 activity through the cell cycle (2011, Saccharomyces cerevisiae,Homo sapiens)
• TLRs crosstalk with the phosphoinositide 3-kinase (PI3K) signaling pathway (2011, Homo sapiens)
• TLR-mediated myeloid differentiation primary response gene 88 (MyD88)-dependent and TIR domain containing adaptor inducing interferon (IFN)B (TRIF)-dependent signaling pathways (2011, Homo sapiens)
• Coexpression network analysis and model of cell wall synthesis in rice (2011, Arabidopsis thaliana,Oryza sativa)
• Extrinsic signal pathways for regulating pluripotency during reprogramming (2011, NA)
• Expression of auxin transport and signaling genes in wild-type (WT) and CKX-4 tubers after GA3-mediated tuber sprouting (2011, NA)
• Different RNA processing events in mammals (2011, NA)
• Toll-like receptor signaling pathway (2011, NA)
• Glucose and glutamine metabolism in cancer cells (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Nymphalis l-album)
• nAChR-mediated signaling in lung squamous cell carcinomas and adenocarcinomas (2011, NA)
• Roles of ALK in the pathogenesis of ALK+ anaplastic large cell lymphoma (ALCL) (2011, NA)
• Expression of cell cycle genes in wild-type (WT) and CKX-4 tubers after GA3-mediated tuber sprouting (2011, NA)
• Ingenuity pathway analysis (IPA) of CDF driven pathway changes in BxPC-3 cells (2011, Citrus macrophylla)
• GSK3 plays pivotal roles in the establishment and maintenance of neuronal polarization (2011, Homo sapiens,Mus musculus,Caenorhabditis elegans,Xenopus laevis)
• GSK3 is a key regulator of axon growth and branching (2011, Homo sapiens,Mus musculus,Caenorhabditis elegans,Xenopus laevis)
• Identification of Novel Molecular Targets for Endometrial Cancer Using a Drill-Down LC-MS/MS Approach with iTRAQ (2011, Saccharomyces cerevisiae,Armoracia rusticana,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Bos taurus,Oryctolagus cuniculus,Mandrillus leucophaeus,Mus musculus,clinical samples)
• Regulation of Brown Fat Adipogenesis by Protein Tyrosine Phosphatase 1B (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Representation of PTEN/Akt/mTOR (phosphatase and tensin homolog/Akt/mammalian target of rapamycin) pathway (2011, Homo sapiens)
• Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component (2011, NA)
• TFM-C-induced alteration to IL-12p40 chaperone interactions (2011, NA)
• Key proteins and pathways in the replication stress response network (2011, NA)
• Tumor suppressor p53 and its signaling pathway (2011, NA)
• Interventions in nuclear factor erythroid 2-related factor 2-Kelch-like ECH-associated protein 1 signaling pathway (2011, NA)
• Correlations of genes in central carbon metabolism with SPPR (2011, Saccharomyces cerevisiae,Diaporthe sclerotioides,PX clade,Schizosaccharomyces pombe,Aspergillus fumigatus,Agaricus bisporus,Aspergillus nidulans,Aspergillus niger,Yarrowia lipolytica,Aspergillus oryzae,Pyricularia oryzae,Fusarium graminearum,Trichoderma reesei,Aspergillus parasiticus,Trichoderma harzianum,Trichoderma atroviride,Fusarium graminearum PH-1,Coprinopsis cinerea,Trichoderma reesei RUT C-30,Terfezia morenoi,Fusarium venenatum,Trichoderma reesei QM9414,Mycobacterium tuberculosis,Bacillus velezensis At1,Planktothrix pseudagardhii OF3,Homo sapiens,Mus musculus,Plasmodium falciparum,NA)
• Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte (2011, NA)
• Regulation of thrombin-induced RelA/p65 nuclear translocation by the Rho-actin pathway (2011, Mus musculus,Homo sapiens)
• Comparative Transcriptomic Analysis of Uveal Melanoma and Normal Uveal Melanocyte (2011, NA)
• F igure 7.— (2011, NA)
• Glycogen synthase kinase 3 modulates the function of key signaling proteins in the wnt pathway (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Bikinia letestui)
• JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors (2011, Homo sapiens,Mus musculus)
• Intestinal carcinogenesis: IKK can go all the way (2011, NA)
• Schematic pathway showing a possible role for STC2 in affecting the PERK signalling pathway (2011, NA)
• Mycobacterial mechanisms of sensing and countering endogenous or exogenous stress (2011, NA)
• Signaling pathway model for taurocholate-accelerated canalicular network formation (2011, NA)
• Reaction scheme for EGFR signal transduction pathway in H1299 cells (2011, NA)
• Classic arginine–nitric oxide synthase–nitric oxide pathway (2011, NA)
• CD36 contributes to inflammation and impaired insulin signalling in adipocytes and macrophages (2011, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Staphylococcus aureus,Candida dubliniensis)
• Convergence of miR-21 target genes and the apoptosis pathway (2011, NA)
• Regulation of Cbk1 and Ace2 in mitosis integrates signals from FEAR and MEN to ensure the proper timing of septum destruction (2011, Saccharomyces cerevisiae,Homo sapiens)
• EP receptor intracellular signaling pathway and its effects on HFL-1 cell migration (2011, Homo sapiens)
• Components of the TLR pathway and genes commonly induced during the innate immune response of zebrafish to bacterial infection (2011, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Bacillus subtilis At2,Streptococcus pyogenes,Haemophilus influenzae,Pseudomonas fluorescens,Mycobacterium tuberculosis variant bovis,Streptococcus sp. group A,Bacillus thuringiensis,Aeromonas hydrophila,Mycobacterium marinum,Vibrio vulnificus,Burkholderia cenocepacia,Vibrio anguillarum,Streptococcus suis,Leptospira interrogans,Lysinibacillus sphaericus,Edwardsiella tarda,Aeromonas salmonicida,Yersinia ruckeri,Streptococcus iniae,Flavobacterium columnare,Aeromonas veronii,Listeria monocytogenes Italy,Staphylococcus aureus Rd.3,Salmonella enterica subsp. arizonae,Mycolicibacterium peregrinum,Francisella sp.,Gallus gallus,Danio rerio,teleost fish,Cyprinus carpio,Calloplesiops altivelis,Carassius auratus,catfish,Gnathostomata,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster,Viral hemorrhagic septicemia virus)
• RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity (2011, NA)
• Apoptotic caspases elicit Tax-independent transcription of the HTLV-1 LTR (2011, NA)
• RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity (2011, NA)
• IL-6 signalling pathway and candidate genes (2011, NA)
• Biological network of genes linked to the canonical pathway "molecular mechanisms of cancer" that were hypomethylated (fold change >1.5) in zebrafish hepatocellular carcinoma compared to healthy liver (2011, Danio rerio,Oncorhynchus mykiss,Oryzias latipes,Poecilia reticulata,Xiphophorus sp.,Homo sapiens,Bos taurus,Arabidopsis thaliana,Walleye dermal sarcoma virus)
• Beta-amyloid signals through microglial MAC1 receptor and PI3K to PHOX (2011, NA)
• States of metabolic imbalance such as malnutrition and obesity have detrimental effects on the HPG axis, principally altering normal GnRH pulsatile release (2011, NA)
• Schematic review of the molecular mechanisms linking diabetes mellitus and colorectal cancer (2011, NA)
• Proposed signaling pathway to the actin cytoskeleton during HIV-1 entry in T lymphocytes (2011, Human immunodeficiency virus 1,Human immunodeficiency virus,Vaccinia virus,Simian immunodeficiency virus,Human immunodeficiency virus 2,Murine leukemia virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• P73 pathway and its regulators.A simplified view of the p73 pathway, of its regulators, and of the molecules that directly or indirectly can modulate its function (2011, Homo sapiens,Mus musculus)
• A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype (2011, NA)
• Signaling pathway induced by Dectin-1 (2011, Saccharomyces cerevisiae,Candida dubliniensis,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Pneumocystis carinii,Coccidioides posadasii,Pneumocystis murina,Mycobacterium tuberculosis,Mycobacteroides abscessus,Mycobacterium ulcerans,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice (2011, Mus musculus,Homo sapiens)
• IGF1R-IR/PI3K/Akt/mTOR pathway and its manipulation through diet (2011, Saccharomyces cerevisiae,Zea mays,Diaporthe sclerotioides,Mus musculus,Rattus norvegicus,Homo sapiens,Helicobacter pylori)
• Extrinsic (death receptor-mediated) and intrinsic (mitochondria-mediated) pathways that lead to apoptosis of HIV infected helper T cells (2011, NA)
• Simplified metabolic pathway of acrylonitrile, modified from Leonard et al., 1999 (2011, NA)
• Lipid metabolism enzymes and P2X7R modulation (2011, NA)
• Signaling molecules involved in the pathway by which IGFBP-3 enhances apoptotic triggers: Inhibition of which can lead to IGFBP-3 having the opposite effect (2011, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Gallus gallus)
• Metabolic regulation by FOXO1 in skeletal muscle (2011, NA)
• Allopregnanolone (APA) mechanism of action promotes neurogenesis (2011, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Bikinia letestui)
• Compartmentalization of TNF-R1 signalling and A-SMase activation (2011, Mus musculus,Homo sapiens)
• Wnt signaling plays central role in embryogenesis and human diseases including cancers (2011, Homo sapiens,Mus musculus)
• Basic signaling pathways and relevant targets together with their inhibitors associated with endocrine resistance Estrogen receptor alpha (ER) and the growth factors (esp (2010, NA)
• Structure and signaling machinery of the Met receptor (2010, NA)
• Lgl/aPKC regulates Yki activity by promoting the formation of Hpo/RASSF complexes (2010, NA)
• Eicosanoid signaling pathway from Ingenuity Pathway Analysis software (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Adeno-associated virus)
• JAK/STAT pathway in infected EPCs (2010, NA)
• Folate metabolic pathway (2010, NA)
• Cell Cycle Pathway: Differentially expressed genes involved in the cell cycle are shown in pink (2010, NA)
• Bayesian network fits for wildtype data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1) (2010, NA)
• Bayesian network fits for mutation data for cycle checkpoint II pathway using (a) Minimum Spanning Tree algorithm (maximum indegree of 1); (b) Bayesian Information Criterion (maximum indegree of 2) (2010, NA)
• Schematic signaling pathway mediated by the L-CBM complex in T and B lymphocytes.Notes: The L-CBM complex acts in the canonical NFKB (p65/p50, cRel/p50) activation pathway mediated by IKKB downstream of TCRs and BCRs (2010, NA)
• Schematic signaling pathway mediated by the L-CBM complex in NK cells.Notes: The L-CBM complex acts in the canonical NFKB activation pathway through activating NK cell receptors (NKR) such as Ly49H, Ly49D, NK1.1, NKG2D, FcGRIII, etc (2010, NA)
• Signal Transduction: RABGEF1 Fingers RAS for Ubiquitination (2010, NA)
• Metabolic flux distribution through branching areas of the central metabolism of MG1655 and ECOM4LA cell lines (2010, Escherichia coli,Escherichia coli K-12)
• Molecular pathways in LSCs of CML (2010, NA)
• Model proposing the attenuation of the Ras-RAF-MEK-ERK pathway by small molecules that stabilize the inhibitory RAF/14-3-3 complex (2010, Homo sapiens,Chlorocebus aethiops,Dipturus trachyderma)
• Activation of mammalian target of rapamycin complex 1 (mTORC1) (2010, NA)
• The kinase cascade and resulting cellular responses of the MAPK signaling pathways (2010, NA)
• Apoptosis pathway triggered by induction of ER stress response and Ca2+ mediated calpain activation (2010, Escherichia coli,Pseudomonas aeruginosa,Vibrio cholerae,Aeromonas hydrophila,Vibrio vulnificus,Homo sapiens)
• Roles of the NFKB-mediated inflammatory pathway in cellular transformation and in cancer cell survival, proliferation, invasion, angiogenesis, and metastasis (2010, NA)
• Main signaling pathways that mediate visfatin/PBEF/Nampt-induced endothelial cell proliferation and migration (2010, NA)
• RAF fusion genes in prostate and gastric cancer and melanoma (2010, Homo sapiens,Mus musculus)
• How DPAGT1 coordinates Wnt signaling with E-cadherin adhesion (2010, Homo sapiens,Canis lupus familiaris,Cricetulus griseus)
• Hypothetical model for Rad18-dependent activation of the FA pathway in response to bulky DNA adducts (2010, Homo sapiens)
• Proposed model for oncogenic Ras-induced suppression of erythropoiesis (2010, Homo sapiens,Mus musculus)
• Simplified schematic of the Wnt/Beta-catenin signaling pathway (2010, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Triportheus paranensis,Microtus arvalis,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus,Allium cepa)
• Functional gene networks identified using IPA from differentially expressed genes between control and 300 nM reversine-treated annulus fibrosus cells (2010, NA)
• LPS-induced signaling pathway for autophagy as predicted from our recent data () and from recent studies (2010, Homo sapiens)
• Cellular affects of TNFA.Tumour Necrosis Factor alpha (TNFA) is produced by macrophages, lymphocytes, fibroblasts and keratinocyte (2010, NA)
• mTOR signaling pathway (2010, NA)
• Impact of HCV infection on ILK signaling (2010, unidentified influenza virus,Enterovirus C,Coxsackievirus B3,Coxsackievirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Activation of the Fas/FasL apoptotic pathway by interaction of Fas+ cells with FasL (2010, Homo sapiens,Mus musculus)
• Signaling pathways that control transcription during transition from exponential growth to diauxic shift and stationary phase (2010, NA)
• Targeting the Hedgehog pathway in cancer (2010, NA)
• Hedgehog signaling pathway in vertebrates (2010, NA)
• Model schematic of Nipah virus-triggered DC immune response mechanisms and antagonist activity of the response (2010, NA)
• Different effects of gut- and brain-derived serotonin on the osteoblast (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells (2010, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Drosophila melanogaster)
• Tumor Necrosis FactorA Regulates Distinct Molecular Pathways and Gene Networks in Cultured Skeletal Muscle Cells (2010, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Drosophila melanogaster)
• Protective effects of OxPLs against acute lung injury and endothelial barrier dysfunction (2010, NA)
• Lithocholic acid (LCA) extends longevity of chronologically aging yeast through two different mechanisms (2010, NA)
• FXR/SHP pathway controlling miR-34a and SIRT1 expression (2010, NA)
• Mitochondrial respiratory stress-induced Akt1 activation and its role in transcriptional activation (2010, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Psidium guajava)
• Simplified diagram of the Ras/ERK pathway and SST effects through PTPs, SHP-1 and SHP-2 (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Phytomonas oxycareni)
• Simplified diagram of PI3K/Akt pathway and SST effects through PTP SHP-1 (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Phytomonas oxycareni)
• TLR4 signalling (2010, NA)
• Interactions between membrane–lipid metabolism, APP processing and Beta-secretase (BACE) activity, cholesterol uptake/efflux and cell cycle regulation (2010, NA)
• Cycling through metabolism (2010, Mus musculus,Rattus norvegicus,Poecilia reticulata,Hypostomus robinii,Homo sapiens)
• NFKB signaling pathway (2010, Nicotiana tabacum,Curcuma longa,Zingiber officinale,Withania somnifera,Cinchona pubescens,Symphonia globulifera,Erythroxylum coca,Phyllanthus emblica,Hibiscus cannabinus,Rauvolfia serpentina,Piper longum,Terminalia chebula,Asparagus racemosus,Tinospora cordifolia,Digitalis purpurea,Cannabis sativa subsp. indica,Plectranthus barbatus,Terminalia arjuna,Colchicum autumnale,Alpinia galanga,Vincetoxicum indicum,Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 8,Glyptocephalus cynoglossus)
• p21-activated kinases in Erbb2-positive breast cancer (2010, Homo sapiens)
• Proposed model for PAO-derived H2O2 participation in stress and development (2010, Vitis vinifera)
• Schematic diagram hypothesizing the role of Decoy/Guardee in mediating defense in chickpea upon Fusarium oxysporum f.sp ciceri (Race 1) challenge (2010, Cicer arietinum,NA)
• The NFAT structure (2010, Homo sapiens)
• Effect of long-term, high altitude hypoxia on the adaptation of uterine artery contractions to pregnancy (2010, Ovis aries,Homo sapiens)
• Proposed role of CnPlc1 in pathogenicity-related signaling in C (2010, NA)
• Crosstalk between the three distinct oscillators that function in the mouse PSM.(a) Schematic diagram of a signalling and a responding cell in the mouse PSM, detailing cyclic genes of the Notch, Fgf and Wnt pathways (2010, Gallus gallus,Danio rerio,Xenopus laevis,Dipnomorpha,Amniota,Zootoca vivipara,Sauropsida,Homo sapiens,Mus musculus,Drosophila melanogaster,Eucalyptus intertexta)
• Mammalian target of rapamycin (mTOR) network (2010, NA)
• Unique glucose metabolic characteristics in GCC may have potential as targets for cancer therapy (2010, NA)
• Signaling network involved in regulation of light responses in Trichoderma species (2010, Aspergillus nidulans,Neurospora crassa,Trichoderma reesei,Trichoderma harzianum,Trichoderma atroviride,Trichoderma viride,Trichoderma virens,Cercospora zeae-maydis,Drosophila melanogaster,Homo sapiens)
• Developmental Programming: Differential Effects of Prenatal Testosterone Excess on Insulin Target Tissues (2010, Homo sapiens,Ovis aries)
• Role IL-6 signaling in CCA inflammation-related epigenetic regulation (2010, NA)
• Functional network connections between HRneg/Tneg signature genes (2010, NA)
• Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells (2010, NA)
• Cell cycle is controlled by the Rb pathway and p53 pathway (2010, NA)
• Procathepsin D/cathepsin D function in cancer progression (2010, NA)
• Working model of the effects of E2 on cell migration (2010, NA)
• Network-Based Identification of Smoking-Associated Gene Signature for Lung Cancer (2010, NA)
• Prostanoid biosynthesis and response pathway (2010, NA)
• Selected signaling pathways and the current targeted therapies related to RCC (2010, NA)
• Protein serine/threonine phosphatases in the DNA damage response pathway (2010, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Xenopus laevis,Schizosaccharomyces pombe,Dipturus trachyderma,Homo sapiens,Oryctolagus cuniculus,NA)
• Nonlinear signaling through the PI3K-Akt pathway (2010, NA)
• Hippo signaling network in mammals (2010, Drosophila melanogaster,Homo sapiens)
• Complementary signaling pathways activated in human cancer cells (2010, NA)
• IPA representation of the complement system pathway enriched in cluster 6, 3 hours post-infestation with P (2010, Psoroptes ovis,Drosophila melanogaster,Dermatophagoides farinae,Rhipicephalus microplus,Parthenos sylvia,Dermatophagoides pteronyssinus,Strongyloides stercoralis,Sarcoptes scabiei,Otodectes cynotis,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Equus asinus x Equus caballus,Bos indicus,Candida dubliniensis,Serratia marcescens,Iris germanica,Mannheimia haemolytica,Homo sapiens,Mus musculus,NA)
• Highly expressed proteins in MII oocytes (2010, Homo sapiens,Mus musculus)
• IPA representation of the canonical pathway for leukocyte extravasation signalling in cluster 4, 24 hours post-infestation with P (2010, Psoroptes ovis,Drosophila melanogaster,Dermatophagoides farinae,Rhipicephalus microplus,Parthenos sylvia,Dermatophagoides pteronyssinus,Strongyloides stercoralis,Sarcoptes scabiei,Otodectes cynotis,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Equus asinus x Equus caballus,Bos indicus,Candida dubliniensis,Serratia marcescens,Iris germanica,Mannheimia haemolytica,Homo sapiens,Mus musculus,NA)
• Representative genes that responded to [BF/S+L/Ep] treatment (2010, Echinacea purpurea,Homo sapiens)
• Stress-induced pathways in the PVN of the hypothalamus of DBA/2J (A) and C57BL/6 (B) mice (2010, NA)
• Toll-like Receptor signalling canonical pathway (2010, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Gallus gallus)
• NRF2-mediated oxidative-stress response pathway (2010, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,mixed sample)
• Highly expressed proteins in zygotes (2010, Homo sapiens,Mus musculus)
• P38 MAPK signaling pathway (2010, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,mixed sample)
• ERK/MAPK signaling pathway (2010, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,mixed sample)
• Correlation of Predicted miRNA Targets with Hosts (2010, NA)
• Complement pathway (2010, Bos taurus,Sus scrofa,Equus caballus,Homo sapiens,Macaca mulatta,Mus musculus,Iris germanica)
• Prediction of diabetic retinopathy: role of oxidative stress and relevance of apoptotic biomarkers (2010, NA)
• Interferon signalling cascade (2010, Bos taurus,Sus scrofa,Equus caballus,Homo sapiens,Macaca mulatta,Mus musculus,Iris germanica)
• Putative TCR signal pathway (2010, NA)
• Putative TLR signal pathway (2010, NA)
• Novel molecular regulation of Wnt/Beta-catenin pathway (2010, NA)
• Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option (2010, NA)
• Runx2-regulated cancer-related gene network (2010, NA)
• mTOR activation supports cancer cell survival (2010, NA)
• Neutrophil apoptosis (2010, NA)
• Simple diagram of FTY720 action in the mitochondria mediated apoptotic pathway (2010, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Saccharomyces cerevisiae,Sequoia sempervirens,Isaria sinclairii,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Middle East respiratory syndrome-related coronavirus)
• Simplified description of the insulin/IGF-1 signal transduction (IIS) pathway in invertebrates and mammals (2010, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Key regulators of the mammalian target of rapamycin signaling pathway (2010, Homo sapiens)
• Brain-derived neurotrophic factor (BDNF) gene and stimulated intracellular signaling cascades after activation of tropomyosin-related kinase (Trk)B (2010, NA)
• Proposed model for Syk in mediating oxidative stress-induced calcium release (2010, NA)
• Canonical and noncanonical nuclear factorKB (NFKB) activation pathways (2010, Homo sapiens,Human T-cell leukemia virus type I)
• Insulin signaling pathway showing binding of insulin with the insulin receptor leading to the activation of glucose transporter 4 which imports glucose into the cell (2010, NA)
• During innate immune activation via LPS-LPB-TLR4, a number of factors of the coagulation pathway are activated, creating the cooperative immuno-coagulative response (2010, NA)
• HBOT affects gene expression in the Nrf2 Pathway (2010, NA)
• Toll-like receptor (TLR)-4 signaling pathway in alcoholic liver disease (2010, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Cell adhesion molecules nectins and associating proteins: Implications for physiology and pathology (2010, Homo sapiens,Mus musculus,Gallus gallus,Enterovirus C,NA)
• KRAS status and clinical outcome in metastatic colorectal cancer patients treated with first-line FOLFOX chemotherapy (2010, Homo sapiens)
• CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons (2010, Mus musculus,Homo sapiens)
• Thrombin-induced ET-1 secretion in RPE is rho/ROCK1/2 dependent (2010, Homo sapiens)
• Schematic diagram showing nimbolide (NL) activity in the TNF-Alpha-induced NFKB signaling pathway (2010, Azadirachta indica)
• Intrinsic control of axon regeneration (2010, NA)
• Biological interaction between glucose and genes up- (light grey) or down-regulated (white) in primary hepatic stellate cells after overexpression of Smad7 (2010, Rattus norvegicus,Homo sapiens)
• RNA helicases of the RIG-I-like receptor (RLR) family play a crucial role in the innate antiviral response (2010, Homo sapiens)
• Schematic view of HMGB1 signal transduction (2010, Homo sapiens,Saccharomyces cerevisiae)
• Mechanism of action of lapatinib (2010, NA)
• HER2 pathway (2010, Homo sapiens)
• An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy (2010, NA)
• The proposed role of high CORT levels on the proinflammatory response triggered by LPS and related to MAP kinase–NFKB pathway in rat brain (2010, NA)
• Scheme of the Wnt signalling pathway including proteins from the RT-PCR array (2010, NA)
• Mechanisms of NFKB activation in T-ALL leukemic cells (2010, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• The main actors intervening in the canonical and noncanonical NFKB activation pathways (2010, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Schematic diagram illustrating an overview of cellular injury and inflammatory-mediated steps in development of leiomyoma as compared with uterine scar formation caused by mechanical injury (i.e., myomectomy and cesarean delivery) (2010, NA)
• The biochemical mechanisms underlying LTP at thalamo-LA synapses (2010, NA)
• Intertwining Threshold Settings, Biological Data and Database Knowledge to Optimize the Selection of Differentially Expressed Genes from Microarray (2010, NA)
• Macrophage infiltration in adipose tissues, oxidative stress and IR (2010, NA)
• Dobutamine and heart-cell contractility (2010, NA)
• PI3K/Akt/mTOR signaling pathway (2010, NA)
• Schematic drawing showing the TNF-driven survival and apoptosis balance (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of endogenous ROS (2010, NA)
• Integration of the identified proteins into the canonical pathway of TLR signaling (2010, Homo sapiens,Rattus norvegicus)
• Viral infection triggers the IFNB signal transduction pathway of the host innate immune system, activating the antiviral state (2010, NA)
• Activation of Gli proteins during vertebrate Hh signaling (2010, Bos taurus,Oryctolagus cuniculus,Danio rerio,Capra hircus,Xenopus laevis,Calloplesiops altivelis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Myostatin activity and muscle growth (2010, NA)
• Cartoon showing the pathway of cardiac fibrosis inhibited by E2/ERB (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Nutritional Programming in the Rat Is Linked to Long-Lasting Changes in Nutrient Sensing and Energy Homeostasis in the Hypothalamus (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Human Th17 differentiation: IL‐1 signaling appears to cooperate with a pathway driven by TGF‐B+ IL‐6/IL‐21/IL‐23 to induce human Th17 cells, associated with expression of ROR‐c and Stat3 (2010, NA)
• Schematic summarizing the present findings (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Mechanism of cAMP inhibition of MAPK activity (2010, NA)
• Hypothesized GABAergic molecular pathway of acquisition/consolidation, reconsolidation and extinction consolidation (2010, NA)
• Signaling pathways regulating GSK3 and functions of GSK3 related to mood regulation (2010, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus)
• Simplified, schematic representation of flavonoid biosynthesis in A (2010, NA)
• Web-accessible DC pathway navigator (2010, NA)
• Wnt/Beta-catenin signaling Ctenophore pathway (2010, Mnemiopsis leidyi,Homo sapiens)
• Stress signalling to fungal SAPK pathways (2010, Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Homo sapiens)
• P38 MAPK signal transduction pathway involved in cytokine production (2010, NA)
• Wnt signaling components regulate ubiquitylation (2010, NA)
• Ubiquitin-mediated regulation of the core Wnt pathway components APC, Axin and Beta-catenin (2010, NA)
• CD28 signaling events (2010, NA)
• Proposed model for how Shh signaling pathway negatively regulates its mitogenic potential through Beta-arrestin 1 (2010, NA)
• Attenuated cytoplasmic dsRNA sensing in hESCs (2010, NA)
• Model: The kinase IKK may activate Htt degradation by a mammalian version of the yeast Cvt pathway (2010, NA)
• Model showing PGE2/EP4/CREB/S100P signaling in a feedback regulatory loop (2010, NA)
• Simplified schematic version of the epidermal growth factor receptor (EGFR) signaling cascade (2010, Homo sapiens)
• Monosodium urate (MSU)-mediated inflammation and the roles of spleen tyrosine kinase (Syk) and Nlrp3 (2010, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Meleagris gallopavo)
• Melatonin regulation of breast cancer cell invasion (2010, NA)
• Beta-Catenin is at the hub of multiple signaling pathways (2010, NA)
• Canonical NFKB signalling pathway (2010, Human gammaherpesvirus 4,Human papillomavirus,Human T-cell leukemia virus type I,Molluscum contagiosum virus,Mus musculus,Rattus norvegicus,Trypanosoma cruzi,Giardia intestinalis,Homo sapiens,Bos taurus,Xenopus laevis,Candida albicans,NA)
• Potential mechanism of the HGF/ c-Met signal pathway hallmarks in lung cancer (2010, NA)
• FHL1 isoform KyoT2 and Notch signaling (2010, NA)
• Schematic diagram of NELL-1 signaling pathways in osteoblast cells (2010, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Ovis aries,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,Gallus gallus,Daucus carota,Anopheles gambiae)
• Three major UPR pathways in metazoans (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,prion)
• a, b Bioactive eicosanoids derived from the arachidonic acid cascade (2010, NA)
• Toll-like receptor (TLR) signalling and inhibition by viral proteins (2010, Homo sapiens,Mus musculus)
• Schematic drawing showing the controversial role of IL-12 on bone resorption at apical periodontal sites (2010, NA)
• Fibroblast Growth Factor (FGF) Receptor Complex and Its Schematic Signaling Pathway (2010, NA)
• TLR signaling pathway and downstream effector molecules (2010, NA)
• AKt pathway mediates ischemia preconditioning (2010, Homo sapiens,Sus scrofa)
• Working model for the role of WRN in the signaling pathways involved in pancreatic cancer cells (2010, Homo sapiens)
• Schematic diagram showing major GPCR signaling pathways (2010, NA)
• Biomarkers of primary open-angle glaucoma (2010, NA)
• Bacterial and host effector molecules with potential probiotic effects (2010, NA)
• Insulin-like growth factor receptor 1 (IGF1R) signaling pathway and potential mechanisms of resistance to IGF1R blockade (red asterisks) (2010, NA)
• TRAF6 and A20 control K63-linked ubiquitination of Beclin 1 to trigger autophagy (2010, Mus musculus,Homo sapiens)
• Vascular Disease in Pre-Diabetes: New Insights Derived from Systems Biology (2010, NA)
• GPCR-modulated channel activity in pituitary cells (2010, NA)
• Pituitary cells express GPCRs that engage the cAMP signaling pathway (2010, NA)
• Dependence of the cyclic nucleotide signaling pathway on Ca2+ influx through Cav channels (2010, NA)
• Mechanisms by which CD44 can modulate cell death (2010, NA)
• Selective elimination of messenger RNA underlies the mitosis–meiosis switch in fission yeast (2010, NA)
• Molecular biology of histidine decarboxylase and prostaglandin receptors (2010, NA)
• The main modulated genes and their reciprocal interactions in the cell (2010, NA)
• Targeting Metabolic Remodeling in Glioblastoma Multiforme (2010, NA)
• Positive effects of CDK8 at pre- and post-initiation steps (2010, Saccharomyces cerevisiae,Homo sapiens)
• Proposed model for Cry toxin action (2010, NA)
• Zfra in the mitochondrial pathway of apoptosis (2010, NA)
• Schematic diagram illustrating the different mechanisms by which P2 receptor subtypes might alter cancer cell function (2010, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,PX clade)
• Simplified view of the canonical Wnt signaling pathway (Modified from ref (2010, NA)
• Currently-known relationships among genes analyzed based on manually curated examination of the published literature within the Ingenuity Pathway Analysis® Knowledge Base (2010, NA)
• In the classical apoptotic pathway of mammalian cells, Fas-ligand binding to its receptor results in the activation of low levels of caspase 8 (2010, NA)
• Regulation of peripheral tolerance by the intrinsic and extrinsic apoptosis pathways in T and B cells (2010, NA)
• ErbB2 cellular signaling pathways and lapatinib mechanism of action (2010, NA)
• Molecular crosstalk between the ER and ErbB1/ErbB2 cellular signaling pathways in endocrine-resistant ErbB2-positive breast cancer cells (2010, NA)
• Selected signal transduction pathways that affect AS of transcripts of genes important in cancer (2010, NA)
• Diagram of TLR signaling pathways (2010, Escherichia coli,Mycobacterium tuberculosis,Helicobacter pylori,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Drosophila melanogaster,Plasmodium falciparum,Homo sapiens,Mus musculus)
• The regulation of lifespan and innate immunity (2010, Caenorhabditis elegans,Homo sapiens)
• Ingenuity Pathway Analysis Network 2 depicting relationship among up-regulation Genes in SL1344 vs SB1117 infection groups at 8 hours (2010, NA)
• Ingenuity pathway Analysis network 1 depicting relationships among up-regulated genes in SB300 infection group relative to that of SB1117 infection group at 8 hours (2010, NA)
• Signaling networks associated with PPARD and inflammatory and invasive gene expression (2010, NA)
• The innate immune induction pathway through RLR activation (2010, Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Hepatitis C virus genotype 3,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Carbon and electron flow in E (2010, NA)
• Simplified overview of the pathways involved in miRNA regulation of gene expression in addiction (2010, NA)
• Mincle- and Dectin-1-mediated signalling in response to mycobacteria (2010, NA)
• Molecular events associated with the repressive effect induced by PTCH1 receptor on the SMO activity and the activation of the Hh signaling pathway mediated by the SHH protein in the primary cilium (2010, Homo sapiens,Rattus norvegicus)
• Cellular events and signaling elements involved in the regulation of SHH expression, GLI activation, and mediation of the Hh activation-induced cellular response (2010, Homo sapiens,Rattus norvegicus)
• Scheme showing the signaling elements and frequent deregulations in the Hh signaling network and potential cross-talk with the EGFR signaling pathway involved in the malignant behavior of cancer cells (2010, Homo sapiens,Rattus norvegicus)
• Downregulation of miR-342 is associated with tamoxifen resistant breast tumors (2010, Homo sapiens,Bos taurus)
• Longevity pathway (2010, NA)
• PTEN in Beta-Cell Growth (2010, NA)
• Host-cell signalling induced by EPEC Tir (2010, Escherichia coli,Helicobacter pylori)
• Mechanisms of malignant transformation by K+ channels (2010, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Functional Characterization of FLT3 Receptor Signaling Deregulation in Acute Myeloid Leukemia by Single Cell Network Profiling (SCNP) (2010, NA)
• Nrf2 cytoprotective signaling pathway (2010, NA)
• Schematic presentation of the summary of our work (2010, NA)
• FoxO1 activates Tlr4 inflammatory pathway in macrophages and affects insulin resistance (2010, NA)
• Foxo3 regulation of hematopoietic progenitor cell activity (2010, Mus musculus,Homo sapiens)
• Cell cycle G1/S check point subnetwork (2010, Homo sapiens,Saccharomyces cerevisiae)
• Hypothetical Scheme Showing the Possible Signaling Circuitry That Controls Cytokinesis in Arabidopsis.Components in the NACK-PQR pathway are shown (2010, NA)
• The AMPK pathway in relation to various molecules (2010, Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Organizing signal transduction through A-kinase Anchoring Proteins (AKAPs) (2010, Homo sapiens,Mus musculus)
• Numbers of reads in the non-normalized and normalized 454 sequence analysis for genes encoding enzymes in the fatty acid and TAG biosynthetic pathways in bitter melon seeds (2010, NA)
• Simulation diagram of the relationship between insulin signaling pathway and hepatocyte apoptosis (2010, Rattus norvegicus,Homo sapiens)
• Diagram illustrating the PS–Tyro3–Akt cell survival signaling pathways (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• A network of hits highly enriched in cell cycle-related genes (2010, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio,clinical samples,Acanthamoeba polyphaga mimivirus)
• Regulation of Wnt signaling in Xenopus CNC (2010, NA)
• Schematic showing another inflammatory pathway that is activated by tissue injury (2010, NA)
• Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells (2010, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Ambrosia artemisiifolia)
• Summary of the proposed molecular mechanism through which 6-shogaol inhibits PMA-induced breast cancer cell invasion (2010, Zingiber officinale)
• Scheme of the JEV-mediated signalling pathways linked to matrix metalloproteinase (MMP-9) expression in brain astrocytes (2010, Japanese encephalitis virus,Homo sapiens)
• Signaling microdomain for specific PIP2 signal (2010, NA)
• Hypothetic model that links GRK5 deficiency to the amyloid and cholinergic hypotheses (2010, Mus musculus,Homo sapiens)
• Bioinformatics Analysis of Macrophages Exposed to Porphyromonas gingivalis: Implications in Acute vs. Chronic Infections (2010, Porphyromonas gingivalis,Homo sapiens)
• Functional module of the CXC chemokine pathway uniquely identified by NeMo (2010, NA)
• EGFR pathway and its main downstream effectors (top) (2010, NA)
• Two-loop model of iADE (2010, NA)
• Proposed signaling scheme for ischemic preconditioning (2010, Oryctolagus cuniculus,Homo sapiens)
• The turnover of P63 on the surface of type II cells (2010, Allogromia sp. A)
• PLC signaling in B cells (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Armoracia rusticana,Human immunodeficiency virus 1,Corynephage beta,Patella vulgata)
• Stbd1 participation in glycogen metabolism and Stbd1 structure (2010, NA)
• Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse (2010, NA)
• Insights into acute myeloid leukemia via single cell network profiling (2010, Homo sapiens,clinical samples)
• Activation of Beta-adrenergic receptor pathway in the heart (2010, NA)
• Ingenuity Pathway Analysis (IPA) of differentially expressed genes between 24 DSS and 56 uncomplicated dengue patients (2010, Homo sapiens,Dengue virus)
• Differential host transcriptional responses within the acute-phase response pathway in r1918-infected WT, TNFRKO, and IL1RKO mice at 1, 3, and 5 dpi (2010, Influenza A virus,unidentified influenza virus,Mus musculus,Homo sapiens)
• Active Cdk1/cyclin B1 complex on the extrinsic death pathway (2010, Homo sapiens)
• Repression of NRF2 signaling by members of the NFKB pathway (2010, Mus musculus,Homo sapiens)
• NRF2-mediated oxidative stress response pathway (2010, Homo sapiens)
• PI3K/Akt signaling pathway (2010, Homo sapiens,Lareunionomyces loeiensis)
• Schematic signal transduction pathways underlying the interfunctional role of CO, NO, and H2S in the modulation of cell survival (2010, NA)
• Scheme illustrating the dynamic reciprocity between MMP9 and the Raf–MEK–ERK pathway, which determines whether cells would continue to proliferate or undergo acinar morphogenesis (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model of GS-mediated apoptosis in HNSCC cells (2010, Homo sapiens,Mus musculus,Bos taurus,Commiphora mukul,NA)
• EGFR-mutated lung cancer: a paradigm of molecular oncology (2010, Homo sapiens,Mus musculus)
• Coxiella burnetii, the Agent of Q Fever, Replicates within Trophoblasts and Induces a Unique Transcriptional Response (2010, Coxiella burnetii,Homo sapiens)
• DNMT inhibitors and PTEN/PI3K/Akt pathway (2010, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Drosophila melanogaster,Linuche aquila,Homo sapiens,Escherichia coli,Human gammaherpesvirus 4)
• Representation of the transduction pathway involved in Cd signaling (2010, NA)
• Summary of TG-FN-mediated cell adhesion and FN fibril formation pathway (2010, Mus musculus,Homo sapiens)
• Comparison of the DC-ATLAS Toll Like Receptor (TLR) 3 pathway with other pathway databases (2010, NA)
• Activation of the NFKB signaling pathway (2010, NA)
• Scalable Approach for Discovering Conserved Active Subnetworks across Species (2010, Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Candida albicans,Pinctada fucata,Homo sapiens,Mus musculus,Escherichia coli)
• Insulin signaling cascade that regulates GLUT4 exocytosis in the plasma membrane in adipose cells (2010, Rattus norvegicus,Homo sapiens)
• Both the NO/cGMP and PI3K/Akt antiapoptotic signals in MCF-10A human mammary epithelial cells, was elicited by pharmacological intervention using pathway inhibitors (e.g (2010, NA)
• Location of 2,4DNT impacted genes in the pathway association network (2010, NA)
• Regulatory PathRNet Only nodes that are close to P38 MAPK Signaling pathway or "S-7" are kept (distance<3) (2010, Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 8)
• Toll-like recepter 4 signaling pathway modified from Wikipedia Commons (2010, NA)
• Hypothetical model for the molecular signaling pathways of vasculogenic mimicry in tumors and anti-vasculogenic mimicry (VM) therapy strategies (2010, NA)
• Diagram showing curcumin and its potential inhibitory effects on the metabolic pathway of arachidonic acid (2010, NA)
• Estrogen and Tamoxifen Metabolic Pathways depicted at the genomic level (2010, Homo sapiens,Rattus norvegicus)
• The TLR/IL-1R-IRAK-NFKB connectivity and signaling in AD brain and in IL-1B+AB42 peptide-stressed HAG cells (2010, NA)
• ID2 in clock resetting (2010, NA)
• Proposed model of VSV-obatoclax synergism (2010, NA)
• Identification of putative signaling regulators for immune-modification (2010, NA)
• Candidate master switch molecules and signaling pathways involved in LPS-induced inflammatory response of monocyte THP-1 cells (2010, NA)
• Tor pathway in the model fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe (2010, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• MAPK signaling pathways generated by GenMAPP (2010, NA)
• Gene list involved in TLR pathway generated by KEGG (2010, NA)
• CoQ10 biosynthesis pathway (2010, NA)
• Interaction of p75NTR and TrkB signaling (2010, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Expression of genes in the GA biosynthetic and signaling pathways (2010, NA)
• PPARG ligands can induce (A) or suppress (B) expression of cox-2 (2010, NA)
• ER alpha nuclear export in breast cancer cells (2010, Homo sapiens)
• Example of synthetic lethality: PARP inhibition in cells deficient in homologous recombination (HR) (2010, NA)
• Therapeutic drugs that target various components of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway (2010, NA)
• Signaling cluster and integrin signaling (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Activation of apoptotic signaling via caspase 3 and gelsolin (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Complex deregulation of the Neuregulin/ERBB2 signaling pathway (2010, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Networks for (A) Biological network (B) Network MDL approach (C) PMDL approach The performance on the algorithms is performed on a biological data set (2010, NA)
• Insulin signaling pathway (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Lambdavirus lambda)
• Composite network presentation of the response to BPDE in normal fibroblasts (2010, Homo sapiens)
• Canonical Wnt signaling pathway (2010, NA)
• Notch signaling pathway (2010, NA)
• Proposed role for two-pore channels in integrative Ca2+signaling (2010, NA)
• Schematic overview of the pyruvate/isocitrate cycle and OGC, important components of the pathway regulating glucose- and glutamine-stimulated insulin secretion (2010, NA)
• Uric acid transport and disease (2010, NA)
• Uric acid transport and disease (2010, NA)
• Proposed model of salt-stress tolerance in plants at cellular level (2010, NA)
• miR-22 Forms a Regulatory Loop in PTEN/AKT Pathway and Modulates Signaling Kinetics (2010, Homo sapiens,Mus musculus,Bos taurus)
• Mechanisms involved in the immune response and C4 intrathecal synthesis against Angiostrongylus cantonensis larvae invasion throughout the damaged blood-brain barrier (BBB) (2010, NA)
• The toll-like receptor 4 (TLR-4) pathway and its activation by NEFA (2010, NA)
• Insulin signal transduction system in individuals with normal glucose tolerance (see text for a detailed discussion) (2010, NA)
• llustration of biochemical interactions: the carnitine shuttle, fatty acid oxidation, and glycolysis (2010, Bos taurus,Sus scrofa,Equus caballus,Homo sapiens,Rattus norvegicus,Zea mays,Meleagris gallopavo)
• Anrep effect requires transactivation of the epidermal growth factor receptor (2010, Felis catus,Homo sapiens)
• Schematic presentation of the signaling pathway induced by HCV for metabolic regulation (2010, Homo sapiens,NA)
• Cdk1 modulates the activity of several DNA damage checkpoint proteins (2010, Saccharomyces cerevisiae,Homo sapiens)
• Cdk1 restricts the pheromone response pathway to the G1 phase of the cell cycle (2010, Saccharomyces cerevisiae,Homo sapiens)
• Proposed model of LH-mediated regulation of MTOR signaling in luteal cells (2010, NA)
• Cartoon illustrates genomic and nongenomic actions of VDR signaling in inhibition of human CYP7A1 gene transcription in human hepatocytes (2010, Homo sapiens)
• Alterations in transforming growth factor beta signaling cause changes in chondrocyte differentiation and osteoarthritis development (2010, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Xenopus laevis)
• Targeting Multiple Kinase Pathways. A Change In Paradigm (2010, Homo sapiens,Mus musculus)
• The signaling pathway from an agonist stimulation to integrin activation (2010, Homo sapiens)
• Several disease pathways involved in AD pathogenesis (2010, Homo sapiens,Mus musculus)
• Multiple effects of ER-819762 on pro-inflammatory responses (2010, NA)
• Ingenuity Pathway Analysis Network (2010, Olea europaea,Vitis vinifera,Sequoia sempervirens,Theobroma cacao,Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic representing the significant changes in gene expression in the lung of Keap1Δ2–3/Δ2–3;CctCre+ mice compared with Keap1flox/flox mice (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Integration of Light Signals by the Retinoblastoma Pathway in the Control of S Phase Entry in the Picophytoplanktonic Cell Ostreococcus (2010, Saccharomyces cerevisiae,Nicotiana tabacum,Diaporthe sclerotioides,PX clade,Schizosaccharomyces pombe,Chlamydomonas reinhardtii,Antirrhinum majus,Ostreococcus tauri,Homo sapiens,Mus musculus)
• Relationships between differentially expressed miRNAs, putative target genes, and functions (2010, NA)
• CXCR5 activate PI3K isoforms through GAlpha-Src-FAK pathway or via GB/G pathway leading to subsequent activation of ERK1/2 (2010, NA)
• Sequencing, Analysis, and Annotation of Expressed Sequence Tags for Camelus dromedarius (2010, NA)
• Depicts the proposed signaling pathway on the basis of information accrued by the current study and available literature (2010, NA)
• Case study of TNF-Alpha-induced NFKB pathway (2010, Homo sapiens,Bos taurus,Armoracia rusticana)
• Metabolic oxidation regulates embryonic stem cell differentiation (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Small cell lung cancer (2010, NA)
• TIF scores for genes in the KEGG colorectal cancer pathway (2010, NA)
• Pathways adapted from KEGG (2010, NA)
• Some key insect recognition, signaling and response genes are missing in the pea aphid (2010, Acyrthosiphon pisum,Homo sapiens)
• Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle (2010, NA)
• Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling (2010, NA)
• Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling (2010, NA)
• Rescuing effects of Korea red ginseng against H (2010, NA)
• PKA pathway (2010, Homo sapiens,Mus musculus)
• Generalized depiction of the energy cost of neurovascular coupling and its impact on astrocytic glucose utilization (CMRglc) (2010, NA)
• Signaling pathway model showing the role of NAADP in the acrosome reaction in sea urchin sperm (2010, NA)
• Model illustrating the role of WDR3 in mediating cross-talk between ribosome biogenesis and p53-mediated cell cycle regulation (2010, NA)
• Functional genetic network as defined by the bioPIXIE tool (Myers et al (2010, Saccharomyces cerevisiae,Arabidopsis thaliana,Aspergillus nidulans,Saccharomyces cerevisiae S288C,Saccharomyces cerevisiae BY4741,Vipera berus berus,Acipenser sturio,Homo sapiens,Mus musculus,Streptomyces noursei)
• Model describing the movement of preleptotene spermatocytes across the BTB (2010, NA)
• Non-classical testosterone signalling pathways (2010, NA)
• Role of the major PD-associated genes in mitochondrial dysfunction (2010, NA)
• Molecular determinants of mitochondrial quality-control networks (2010, NA)
• CAMP-independent PKAc activation by dissociation of an NFKB-IKB-PKAc complex in thrombin- and collagen- stimulated platelets (2010, NA)
• Working model for S1P/SK/S1PR interplay during acrosomal exocytosis (2010, NA)
• Proposed role of IRS-1 in regulating SHPS-1 phosphorylation under hyperglycemic conditions (2010, Mus musculus,Rattus norvegicus,Sus scrofa,Homo sapiens)
• Fibrinogen-bound latent TGFB activated by reactive astrocytes after injury (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• Solid tumors activate the NFKB pathway to maintain cell survival (2010, NA)
• Constitutive NFKB pathway activation in multiple myeloma (2010, NA)
• Role of BCR signaling to NFKB in ABC DLBCL (2010, NA)
• Proximal signaling events in the TCR-coupled signaling pathway (2010, NA)
• Signaling pathway for zinc prevention of atherosclerosis in monocytes/macrophages and vascular endothelial cells: a proposed hypothesis (2010, NA)
• Hedgehog takes a new “RHOad” to angiogenesis (2010, Drosophila melanogaster,Chinchilla chinchilla,Homo sapiens)
• Major gene products affected by virulent infection (2010, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,Influenza A virus H3N2,Sus scrofa,Mustela putorius furo,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Comparison of protein and gene expression studies (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Segment-Specific Neuronal Subtype Specification by the Integration of Anteroposterior and Temporal Cues (2010, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Xenopus laevis,Cavia porcellus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Matthiola incana)
• Proposed p38 MAPK signaling pathway involved in cAMP-induced MRP2 translocation in hepatic cells (2010, Homo sapiens,Rattus norvegicus)
• Proposed role for AMPK in the kidney in coupling catabolic pathways requiring ATP hydrolysis (primarily sodium transport) with metabolic pathways leading to ATP synthesis (primarily fatty acid and glucose oxidation) (2010, NA)
• HSPB6-induced smooth muscle relaxation (2010, NA)
• Smo conformational changes, trafficking and pathway activation (2010, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Dkk1 Stabilizes Wnt Co-Receptor LRP6: Implication for Wnt Ligand-Induced LRP6 Down-Regulation (2010, Bos taurus,Armoracia rusticana,Capra hircus,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• PPAR Signaling Pathway and Cancer-Related Proteins in Celiac Disease-Associated Tissue Damage (2010, Homo sapiens)
• CFTR Depletion Results in Changes in Fatty Acid Composition and Promotes Lipogenesis in Intestinal Caco 2/15 Cells (2010, Mus musculus,Rattus norvegicus,Cricetus cricetus,Psammomys obesus,Armoracia rusticana,Candida dubliniensis,Moloney murine leukemia virus,Cowpox virus,Homo sapiens,Bos taurus)
• Aging-related upregulation of NFKB signaling in VSMC (2010, NA)
• Aging-related upregulation of AP-1 signaling in VSMC (2010, NA)
• Stress-induced regulation of TauT by p53 and c-Jun via JNK signaling pathway (2010, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana,Renilla reniformis)
• APE1 has dual roles in redox and DNA repair (2010, NA)
• Schematic overview of DNA-repair pathway (2010, NA)
• Insulin/IGF1 signalling pathways and AD (2010, Homo sapiens)
• Description of the sex hormone metabolic pathway: genes involved in synthesis, bioactivation, metabolism, and inactivation of estrogen and other hormones (2010, NA)
• PI3K/AKT signaling pathway (2010, NA)
• The regulation of miR-203 expression in differentiating normal and HPV-positive epithelia (2010, Homo sapiens,vectors)
• Membrane fusion-induced host cell signaling (2010, Respiratory syncytial virus,NA,NA)
• Regulation of Ste12p activity in S (2010, NA)
• Proposed model for the mechanism of farnesol protection against OX stress (2010, Candida albicans)
• Schematic view of the GSL metabolism pathways (2010, NA)
• Regulation of mTORC signaling networks (2010, NA)
• Disorders of GSL and ganglioside degradation (2010, NA)
• Signaling pathways involving molecular markers for human breast cancer (2010, NA)
• Chromaffin cell genes involved in catecholamine biosynthesis, storage, secretion and degradation (2010, Rattus norvegicus,Homo sapiens)
• Signaling pathways and targets for LAM (2010, NA)
• Carbon Assimilation Network in Escherichia coli Is Densely Connected and Largely Sign-Determined by Directions of Metabolic Fluxes (2010, Escherichia coli)
• E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,vectors)
• Yeast cell cycle KEGG pathway and reconstructed network by three different algorithms (2010, NA)
• Tumor selectivity of several oncolytic viruses (2010, NA)
• Destruction of the Beta-catenin (Beta-Cat) destructor Axin (2010, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis)
• RNAi Suppression of Arogenate Dehydratase1 Reveals That Phenylalanine Is Synthesized Predominantly via the Arogenate Pathway in Petunia Petals (2010, Petunia x hybrida)
• Models of the Hippo pathway in Drosophila and mammals (2010, NA)
• Caveat mTOR: aberrant signaling disrupts corticogenesis (2010, Homo sapiens,Mus musculus)
• TOM1L2 and genes associated with Alzheimer's disease in the human interactome (2010, NA)
• Endosomal and cytoplasmic pathways for virus recognition and IFN production (2010, Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,West Nile virus,Measles morbillivirus,Japanese encephalitis virus,Murid betaherpesvirus 1,Encephalomyocarditis virus,Reovirus sp.,Murine hepatitis virus,Lyssavirus rabies,Dengue virus type 2,Murine coronavirus,Murine norovirus,Mengo virus,Replication competent viruses,Mammalian orthoreovirus 3,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,Drosophila melanogaster,Gallus gallus,NA,NA,NA,NA)
• p38 MAPK mediates the transcriptional response to stress (2010, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Integrin signalling at focal adhesions (2010, NA)
• TAK1·TAB2·NLK complex negatively regulating canonical Wnt pathway (2010, Homo sapiens,Mus musculus)
• Immunoregulatory pathways (2010, NA)
• Main steps and key regulators in blood and lymphatic vasculature development (2010, NA)
• p38 MAPK signaling pathway that is involved with pituitary adenoma nitroproteins (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic diagram showing the RAS-MAPK signal transduction pathway and affected disease genes in disorders of the neurocardiofacialcutaneous syndrome family (2010, Panthera pardus,Homo sapiens)
• Four flux sensors of the in silico cell (2010, NA)
• Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration (2010, Homo sapiens,Saccharomyces cerevisiae,Plasmodium falciparum)
• Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration (2010, Homo sapiens,Saccharomyces cerevisiae,Plasmodium falciparum)
• Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration (2010, Homo sapiens,Saccharomyces cerevisiae,Plasmodium falciparum)
• Reconstruction of Gene Regulatory Modules in Cancer Cell Cycle by Multi-Source Data Integration (2010, Homo sapiens,Saccharomyces cerevisiae,Plasmodium falciparum)
• Mechanisms and pathways targeted by mutations in MPN (2010, NA)
• Map of selected p53 pathway-associated genes that harbor known or potential functional SNPs (octagon-shaped boxes) and their closely interacting genes (rectangular boxes) (2010, NA)
• NFKB in conventional T-cell activation (2010, NA)
• Proposed model for NFKB repression by TRAF3 in LTBR activation (2010, NA)
• Mechanistic model of KLF11-mediated tumor suppression and its antagonism by an oncogenic pathway (2010, NA)
• Cyclical mTOR-independent autophagy pathway with multiple drug targets for neurodegenerative diseases (2010, NA)
• Moe and Rho1 function in apoptosis based on genetic, biochemical, and subcellular localization data (2010, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus,Xenopus laevis,Matthiola incana,Escherichia coli BL21)
• Putative signaling pathway of S1P5 (2010, NA)
• Comparative Genomics of Flowering Time Pathways Using Brachypodium distachyon as a Model for the Temperate Grasses (2010, Arabidopsis thaliana,Zea mays,Triticum aestivum,Hordeum vulgare,Brachypodium distachyon,Triticum monococcum,Homo sapiens)
• The three complement activation pathways, converging to cleave C3 (2010, Saccharomyces cerevisiae,Candida albicans,Kluyveromyces lactis,Trichophyton rubrum,Staphylococcus aureus,Pseudomonas aeruginosa,Sphingomonas paucimobilis,Homo sapiens,Mus musculus)
• Signaling pathways activated by DMXAA (2010, Homo sapiens)
• NFKB Signaling Pathway (2010, NA)
• Uncovering Molecular Biomarkers That Correlate Cognitive Decline with the Changes of Hippocampus' Gene Expression Profiles in Alzheimer's Disease (2010, NA)
• Significant signaling pathway networks mined from pituitary adenoma comparative dataset (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Differentially expressed genes in the estrogen receptor signaling pathway (2010, Homo sapiens,Rattus norvegicus)
• Differentially expressed genes in the ERK/MAPK signaling pathway (2010, Homo sapiens,Rattus norvegicus)
• Differentially expressed genes in the TGFB signaling pathway (2010, Homo sapiens,Rattus norvegicus)
• Differentially expressed genes in the cAMP signaling pathway (2010, Homo sapiens,Rattus norvegicus)
• Cartoon representation of the proposed PKG-induced signaling pathway that modulates neuronal KATP channel function (2010, Mus musculus,Homo sapiens)
• TLR/IL-1R signalling pathways (2010, NA)
• CD40 responsiveness in Leishmania-infected macrophages: crosslinking of anti-CD40 antibody activates p38 MAPK-induced leishmanicidal function via iNOS2 induction (2010, Leishmania major,Leishmania donovani,Plasmodium berghei,Leishmania mexicana,Leishmania amazonensis,Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium avium,Homo sapiens,Mus musculus,Hepatitis B virus,Candida albicans)
• Semaphorin signaling (2010, NA)
• Inhibition of the Proprotein Convertases Represses the Invasiveness of Human Primary Melanoma Cells with Altered p53, CDKN2A and N-Ras Genes (2010, NA)
• Mitochondrial role in the development of insulin resistance and T2DM (2010, NA)
• Signaling complexes are induced by TNFA to mediate NFKB activation, apoptosis, and necroptosis (2010, NA)
• Proposed model of a EGFR/Beta-catenin/cyclin D1 signaling pathway in oral cancer (2010, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Simplified Overview of the Purine Metabolism PathwayThe scheme is derived from KEGG Pathways hsa00230 (purine metabolism) and hsa00240 (pyrimidine metabolism) (2010, NA)
• Mevalonate pathway and the pleiotropic effects of statins (2010, Homo sapiens,Oryctolagus cuniculus)
• Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair (2010, Homo sapiens,Mus musculus,Oryzias latipes)
• ERK/MAPK signaling pathway that is involved with pituitary adenoma comparative-proteomic data (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Selective inhibition of human brain tumor cell proliferation via multifunctional quantum dot-based siRNA delivery (2010, NA)
• Survival pathways with their cross-talk and immune regulatory mechanisms are shown in this pictorial representation of the Reed-Sternberg (R-S) cell (2010, NA)
• Regulation of Beta-catenin levels in canonical Wnt/Beta-catenin signaling pathway (2010, NA)
• How the presence of virus acts on innate immune system components, i.e (2010, Human alphaherpesvirus 1,unidentified influenza virus,Human betaherpesvirus 5,Human T-cell leukemia virus type I,Enterovirus C,Betapolyomavirus macacae,Influenza C virus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model for the I3C disruption of a cross-regulatory positive feedback loop involving expression of GATA3 and ERA by stimulating the degradation of ERA protein (2010, NA)
• Metabolic feedback loops affecting gene expression in Saccharomyces cerevisiae (2010, NA)
• Comparative lipoate metabolism in protozoan parasites (2010, NA)
• Stimuli and factors involved in yeast chronological aging (2010, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Prevention trumps treatment of antibody-mediated transplant rejection (2010, Homo sapiens,Macaca fascicularis)
• Ovary: basic biology and clinical implications (2010, NA)
• Schematic model for UAG impact on EPC physiology (2010, Homo sapiens,Mus musculus)
• Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,Danio rerio,Chlorocebus aethiops,Derris trifoliata,Mus musculus,Bovine adenovirus 3)
• Relationship of NFKB to genes identified as “linearly” changing with age on the basis of cocitation analysis (Genomatix BibliosphereTM) is shown as a Bibliosphere image (2010, NA)
• P38 MAPK signal transduction in melanogenesis (2010, Mus musculus,Dipturus trachyderma,Homo sapiens)
• RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? (2010, NA)
• PI3K/Akt signaling pathway (2010, NA)
• Current understanding of breast cancer progression mediated by ATX–LPA signalling axis (2010, NA)
• Transcriptional Regulation of the IGF Signaling Pathway by Amino Acids and Insulin-Like Growth Factors during Myogenesis in Atlantic Salmon (2010, Danio rerio,Oncorhynchus mykiss,teleost fish,Cyprinus carpio,Salmo salar,Dipnomorpha,Salmo trutta,Takifugu rubripes,Tetrapoda,Pagrus pagrus,Tetraodon nigroviridis,Gasterosteus aculeatus,Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Lareunionomyces loeiensis,Cerobasis alpha)
• Adaptation of Group A Streptococcus to Human Amniotic Fluid (2010, NA)
• Schematic diagram illustrating the proposed signaling pathway involved in LTA-induced cPLA2/COX-2–dependent airway inflammation (2010, Homo sapiens,Mus musculus,Staphylococcus aureus)
• Schematic depiction of TRPM8 regulation by A2A- and Beta-adrenoreceptors (2010, Homo sapiens,Rattus norvegicus)
• Nitric oxide signaling pathway (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Summary of PPARG transcriptional mechanisms (2010, NA)
• Schematic drawing summarizing the signaling pathway downstream from CB1 receptors in cerebellar granule cell precursors (2010, Mus musculus,Homo sapiens)
• Transcripts regulating the mammalian cell cycle are up-regulated in the proliferative-phase endometrial epithelium (2010, Homo sapiens)
• Relationship between increased production of IPP by GAS and signaling of GD T cells (2010, NA)
• Allosteric regulation underlies the complex binding−function relationship in cellular networks (2010, Saccharomyces cerevisiae,Theobroma cacao,Homo sapiens,Mus musculus,Equus caballus)
• Host defence signaling pathways in Caenorhabditis elegans model (2010, NA)
• Corticosteroid-triggered multiple tentative rapidly influencing neuronal function (2010, NA)
• COX-2 inhibitors on apoptosis (2010, NA)
• Schematic drawing of the four upstream molecular signaling pathways of p27 expression that could lead to activation of the unusually long 5'-untranslated region (5'-UTR) (-575) of p27 mRNA by 4-hydroxytamoxifen, dexamethasone and retinoic acids (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Betapolyomavirus macacae)
• Cross control between Wnt and TGFB in part through Runx2 in osteoblasts (2010, NA)
• K-ras mutation governs the effects of inhibition of epidermal growth factor receptor (EGFR) on the Ras/Raf/Mek signaling pathway (2010, NA)
• Parkinson's disease (PD)-related gene pathway in response to MG132, methylmercury (MeHg), and cadmium (Cd) in MEF cells (2010, NA)
• Changes in cell cycle regulation in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells (2010, NA)
• Antioxidant and phase II detoxifying enzyme genes in response to MG132 (A), methylmercury (MeHg, B), and cadmium (Cd, C) in MEF cells (2010, NA)
• The molecular basis of morphine peripheral analgesia (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic showing cytoplasmic signaling pathway from ATM to TSC2 via LKB1 and AMPK to repress mTORC1 and induce autophagy (2010, Mus musculus,Homo sapiens)
• Proposed model of miR-486 regulation and function in muscle cells (2010, NA)
• Emerging models for the role of Beta-arrestin in wingless (from Drosophila) and the oncogene int-1 (WNT) signalling (2010, NA)
• Beta-arrestin related to the oncogene WNT1 signalling (2010, NA)
• Effector pathways stimulated by Beta-ARs (2010, NA)
• Schematic depiction of the signalling pathways stimulated by cholecystokinin (CCK) activation of the CCK1 receptor (2010, NA)
• The pathway signaling to ERESs (2010, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli,Drosophila melanogaster,Lareunionomyces loeiensis)
• Simplified illustration of the epidermal growth factor receptor (EGFR) pathway with the RAS/MAPK and PIK3CA/PTEN cascades (2010, NA)
• Differential gene expression in M (2010, Methanosarcina acetivorans,Homo sapiens)
• PTEN signaling pathway (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Gallus gallus,Cyprinus carpio,Cyprinus carpio color,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens,Caenorhabditis elegans)
• Schematic model for the role of ROS/Akt/ASK1/p38 signaling pathway in nickel-induced apoptosis (2010, Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Differences between TRAIL- and AD5-10-induced signaling pathways (2010, NA)
• Proposed model for the regulatory mechanisms of the Ras and cAMP signaling pathways in stress response and antifungal drug susceptibility in C (2010, NA)
• Signaling cascades that regulate A (2010, NA)
• Downstream signalling pathways of TNFA (2010, NA)
• Ras cycle control of cell proliferation, differentiation or death (2010, NA)
• The Rap1 pathway in Dictyostelium regulating adhesion and cell morphology (2010, Dictyostelium discoideum,Dictyostelium discoideum AX2,Dictyostelium discoideum AX3,vectors,unidentified shuttle vector,Homo sapiens,Escherichia coli,Schizosaccharomyces pombe,Kobus kob)
• Proposal of the regulatory loop of miR-24, miR-34a, and HNF4A in bile acid synthesis (2010, NA)
• Schematic diagram depicting a pathway that connects polycystins and calcium signaling to HDAC5 and MEF2C-based transcription activation in the suppression of epithelial cyst formation (2010, NA)
• Serine/threonine kinase Akt, also known as protein kinase B (PKB), has become a major focus of attention because of its critical regulatory role in diverse cellular processes, including cancer progression (2010, NA)
• Retrograde mechanisms in NMJ formation (2010, NA)
• Working model of signaling pathways in postsynaptic assembly (2010, NA)
• Upregulation of SOCS-3 and PIAS-3 Impairs IL-12-Mediated Interferon-Gamma Response in CD56+ T Cells in HCV-Infected Heroin Users (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Influenza A virus,Homo sapiens,Armoracia rusticana,NA)
• EGR3 and miRNAs involving in signaling pathways and regulatory networks in schizophrenia and nervous system (2010, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Escherichia coli,Gallus gallus,Canis lupus familiaris)
• Regulation of intracellular Stat3 signalling (2010, NA)
• Proposed mechanism for ERK1/2 activation as a key signaling pathway targeted by PTHrP(1-36) through interaction with EGFR, TGFB, and VEGF in renal tubuloepithelial cells (2010, NA)
• Schematic diagram of AGE-induced CTGF expression is shown (2010, Mus musculus,Rattus norvegicus,Adenoviridae,Homo sapiens)
• Actin cytoskeleton signaling pathway as represented by Ingenuity Pathway Analysis (2010, NA)
• Phosphatidylinositol 3-kinase (PI3K) signaling cascade (2010, Homo sapiens)
• Signaling pathways involved in Alpha-TEA-induced apoptosis in human ovarian cancer cell lines (2010, NA)
• Proposed mechanism for B2M mAb inhibition of AR and cell proliferation, survival, and progression through a MAPK/SREBP-1 signaling pathway in prostate cancer cells (2010, Homo sapiens,Mus musculus)
• Binding of Herpes Simplex Virus Type-1 Virions Leads to the Induction of Intracellular Signalling in the Absence of Virus Entry (2010, NA)
• Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement (2010, NA)
• BS and M chloroplast distribution of proteins involved in primary carbon metabolism (2010, Zea mays)
• Interaction between sFRP4 and the Wnt signaling pathway (2010, Mus musculus,Rattus norvegicus,Gallus gallus,Sus scrofa,Homo sapiens)
• Proposed model for the signal transduction pathways involved in TGFB1-mediated fibroblast-myofibroblast differentiation (2010, Bos taurus,Homo sapiens)
• The multi-stage autophagic process (2010, NA)
• A proposed mechanism of MNTX synergistic effects with temsirolimus on inhibition of VEGF-induced angiogenic events (2010, NA)
• The regulatory network of apoptosis in BCL11B and its related genes (2010, NA)
• Genetic alterations of the Ras-dependent ERK1/2 pathway in cancer (2010, Homo sapiens,Mus musculus)
• The Ras-Raf-MEK-ERK1/2 MAP kinase pathway (2010, Homo sapiens,Mus musculus)
• In silico feasibility of novel biodegradation pathways for 1,2,4-trichlorobenzene (2010, NA)
• PPARG agonists inhibit Stat3-mediated IL-6 gene expression in myeloma cells (2010, NA)
• Nodal-Smad2 signaling regulation of the BMP pluripotency pathway in mouse ES cells (2010, NA)
• KLA increases mRNA expression of genes involved in sphingolipid biosynthesis (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• Tumor-associated angiogenesis is sustained through stromal microenvironment crosstalk (2010, NA)
• Signalling pathways in vascular endothelial cells that contribute to the beneficial effects of oligonol on hyperglycaemia-induced eNOS dysfunction (2010, NA)
• Uric Acid and Antioxidant Effects of Wine (2010, Homo sapiens)
• Caspase-1 Activation via Rho GTPases: A Common Theme in Mucosal Infections? (2010, Escherichia coli,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Shigella flexneri,Citrobacter rodentium,Francisella tularensis,Burkholderia pseudomallei,Candidatus Sodalis pierantonius str. SOPE,Salmonella enterica subsp. enterica serovar Dublin,Salmonella enterica subsp. enterica,Mus musculus,Cavia porcellus,Homo sapiens,Bos taurus)
• Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells (2010, NA)
• Signaling pathway of NO-induced SMC relaxation in mouse small airways (2010, NA)
• Canonical Wnt pathway (2010, NA)
• Pathway for induction of apoptosis in H (2010, NA)
• Interconnections between p53 and IGF-1/AKT/mTOR pathways (2010, NA)
• Possible mechanisms for ganglioside-induced autophagic cell death in astrocytes (2010, NA)
• Left-right AWC asymmetry is controlled by calcium (2010, NA)
• Signaling pathways controlling ENS precursor migration and lamellipodia formation (2010, Mus musculus,Homo sapiens)
• T-cell activation, proximal signalling complex and activation of transcription factors (2010, NA)
• Biosynthetic pathway for anthocyanins, caffeoylquinates, and other major phenolic derivatives in potato tuber (2010, Solanum tuberosum,Homo sapiens)
• Morphine-induced reduction of TSP1 levels via TGFB1 and its impact on synapse formation (2010, Rattus norvegicus,Homo sapiens)
• Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction (2010, NA)
• Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction (2010, NA)
• Myelin Activates FAK/Akt/NFKB Pathways and Provokes CR3-Dependent Inflammatory Response in Murine System (2010, NA)
• Genome Sequence of the Pea Aphid Acyrthosiphon pisum (2010, Acyrthosiphon pisum,Homo sapiens)
• miR-223 is implicated in the CREB signaling pathway (2010, NA)
• Hepatic cholesterol biosynthesis pathway gene expression is globally overexpressed in the Chga knockout mouse (2010, Mus musculus,Homo sapiens)
• Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse (2010, Mus musculus,Homo sapiens)
• Adrenal insulin signaling and glucose transport gene expression is overexpressed in the chromogranin A (Chga) knockout mouse (2010, Mus musculus,Homo sapiens)
• Simplified diagram of EGFR/ErbB1 signaling pathways in MSC physiology (2010, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens)
• Dihydrotestosterone activates the MAPK pathway and modulates maximum isometric force through the EGF receptor in isolated intact mouse skeletal muscle fibres (2010, NA)
• Schematic diagram summarizing the isoform-specific effects of the Numb proteins on the activation of the Notch pathway and the regulation of cellular Ca2+-regulating systems in PC12 cells under stress conditions (2010, NA)
• Epac: novel cyclic-adenosinemonophosphate (cAMP) mediators (2010, Homo sapiens)
• Nutrient sensing machinery in K- and L-cells (2010, NA)
• Strain-induced quantitative mRNA-expression analysis of PDL cells related to MAP-kinase signalling and cell cycle, ECM and integrins, and growth factor pathways (2010, NA)
• Tissue level and signalling pathways for PGE2 is presented (2010, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Lycium andersonii)
• Cyclin D3-specific deregulated genes and their functional networks (2010, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• Pathway for cholesterol synthesis from 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) by HMG CoA reductase and its inhibition by statins (2010, NA)
• Diagram depicting how tTG participates in an EGFR/Src signaling pathway that leads to enhanced cancer-cell growth (2010, NA)
• Endothelin-1 Inhibits Prolyl Hydroxylase Domain 2 to Activate Hypoxia-Inducible Factor-1A in Melanoma Cells (2010, NA)
• TWISTing Stemness, Inflammation, and Proliferation of Epithelial Ovarian Cancer Cells through MIR199A2/214 (2010, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Asbestos has pleiotropic effects on cell signaling pathways (2010, Meleagris gallopavo,Homo sapiens)
• An engineered T-cell proliferation regulatory system utilizing a synthetic RNA device to achieve drug-mediated modulation of cell signaling and proliferation (2010, synthetic RNA,Homo sapiens)
• Downstream effectors of the ErbB receptor signalling pathway (2010, NA)
• Signal transduction pathway from integrin receptors to actin cytoskeleton (2010, NA)
• A working model for endosomal transport involving CLC-5 and KIF3B interaction in polarized cells (2010, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Chlorocebus aethiops,Phragmites australis,Escherichia coli BL21,Paracentrotus lividus,Avian myeloblastosis virus)
• Pathways leading to the type I interferon production (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 4,Molva molva,NA)
• Vascular Endothelial Growth Factor receptor binding and downstream signaling pathway (2010, NA)
• TNFA induced signaling (2010, Homo sapiens,Mus musculus)
• NADHc generated by sorbitol oxidation is reoxidized to NAD+c largely by enzymes that promote the development of diabetic complications (2010, NA)
• Model illustrating the dynamic overlapping phases of early events of KSHV infection in endothelial and fibroblast cells and KSHV-induced signal pathways and their role in infection (2010, NA)
• Sites within the early steps of the insulin signaling pathway affected by OGT and O-GlcNAcylation (2010, Mus musculus,Homo sapiens)
• Some of the pathways that may contribute to the expression of D3 in pathologic ventricular remodeling (2010, NA)
• Induction of IFNs after virus infection in IFNB pretreated human DCs (2010, NA)
• Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• Scheme of known Wnt pathways (2010, Gallus gallus,Xenopus laevis,Coturnix coturnix,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Drosophila sp. in flies,Homo sapiens,Lareunionomyces loeiensis)
• Schematic junctional organization and Beta-catenin signaling in CNS ECs: comparison of brain and retina (2010, Gallus gallus,Xenopus laevis,Coturnix coturnix,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Drosophila sp. in flies,Homo sapiens,Lareunionomyces loeiensis)
• Curcumin’s targets intracellular components implicated in cell proliferation signaling pathway in prostate cancer cells (2010, NA)
• The regulation of neuronal migration and neurite outgrowth by the MRTF/Srf pathway (2010, NA)
• Network of proteins, functional classes and cell processes modulated in prostate cancer cells after curcumin treatment (2010, NA)
• Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE (2010, NA)
• Transcriptome Profiles of Carcinoma-in-Situ and Invasive Non-Small Cell Lung Cancer as Revealed by SAGE (2010, NA)
• Signaling pathways involved in LPS induced TNFalpha production in human adipocytes (2010, NA)
• Proposed model for 17Beta-estradiol effect on human MMP-2 promoter activity mediated by ERA and MAP Kinase-ERK1/2 signalling pathway (2010, NA)
• Neurotrophic and neuroprotective pathways targeted by lithium (2010, NA)
• Key signaling pathways involved in testosterone-mediated mitigation of sarcopenia in aging (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• mir-100 and mir-22 target known oncogenes that influence the PI3K/AKT/mTOR pathway (2010, Homo sapiens)
• Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota (2010, Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Mouse mammary tumor virus,Respiratory syncytial virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Japanese encephalitis virus,Murid betaherpesvirus 1,Encephalomyocarditis virus,Rous sarcoma virus,Escherichia coli,Pseudomonas aeruginosa,Vibrio cholerae,Clostridioides difficile,Bifidobacterium longum,Lacticaseibacillus rhamnosus GG,Bacteroides thetaiotaomicron,Clostridioides difficile CD3,Candidatus Arthromitus sp. SFB-mouse,Mus musculus,Rattus norvegicus,Homo sapiens,human metagenome,NA,NA)
• Target gene regulatory network, NFKB/RelA:P50 (2010, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Theileria parva)
• Systems Biology Approach Uncovers Cellular Strategies Used by Methylobacterium extorquens AM1 During the Switch from Multi- to Single-Carbon Growth (2010, NA)
• Roles of iron in the development of colorectal cancer (2010, NA)
• RAS-RAF-MEK-ERK signaling pathway (2010, NA)
• Prokineticin (PROK1) induction of regulator of calcineurin 1 isoform 4 (RCAN1-4) and interleukin (IL-11) (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Adenoviridae,unidentified shuttle vector,Bombina variegata)
• Network of ABA-induced stomatal closure (2010, NA)
• Primary Metabolism of Chickpea Is the Initial Target of Wound Inducing Early Sensed Fusarium oxysporum f. sp. ciceri Race I (2010, Fusarium oxysporum,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Solanum tuberosum,Hordeum vulgare,Brassica napus,Saccharum officinarum,Ipomoea batatas,Cicer arietinum,Scutellaria baicalensis,Vicia faba,Brassica rapa,Brassica juncea,Ustilago maydis,Cucumis melo,Alternaria brassicicola,Peronospora farinosa,Sinapis alba,Eschscholzia californica,Fulvia fulva,Macrophomina phaseolina,Glycyrrhiza echinata,Uromyces viciae-fabae,Oryza coarctata,Fusarium circinatum,Fusarium oxysporum f. sp. ciceris,Fusarium oxysporum f. sp. lactucae,Pseudomonas syringae,Cereibacter sphaeroides,Ralstonia solanacearum,Spiroplasma citri,Caenorhabditis elegans,Manduca sexta,Plasmodiophora brassicae,Cucumber mosaic virus,NA,Homo sapiens)
• Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways in vivo (2010, NA)
• IL-6 signalling events (2010, NA)
• IL-1 and TNF signal transduction events (2010, NA)
• Signalling pathways that regulate cell wall remodelling of Candida albicans (2010, Candida albicans,Homo sapiens)
• Alternative mechanisms exist for the induction of inflammatory and apoptotic genes in the absence of the IFNA/B receptor during influenza virus infection (2010, NA)
• Biosynthesis of tetronate RK-682 (2010, Escherichia coli,Saccharopolyspora erythraea,Stigmatella aurantiaca,Streptomyces longisporoflavus,Streptomyces sp. 88-682,Human immunodeficiency virus 1,uncultured actinomycete)
• Molecular targets in NFKB pathway modulated by PEITC and SFN (2010, NA)
• Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN (2010, NA)
• Cytosine Methylation Dysregulation in Neonates Following Intrauterine Growth Restriction (2010, NA)
• Janus kinase/signal transducer and activator of transcription/suppressor of cytokine signalling (JAK/STAT/SOCS) axis (2010, Homo sapiens)
• Proposed model of how immune response pathways affect clinical outcome in ER- breast cancer (2010, Homo sapiens,Molva molva)
• TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice (2010, Mus musculus,Homo sapiens)
• CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts (2010, NA)
• Platelet interactions with Staphylococcus aureus (2010, Staphylococcus aureus,Homo sapiens)
• Hog1 stress-activated protein kinase (SAPK) signalling (2010, Saccharomyces cerevisiae,Homo sapiens)
• Possible mechanism by which Wnt determines the specificity of signalling pathway (2010, Homo sapiens,Mus musculus)
• TNFA signaling pathways to NFKB activation (2010, NA)
• Examples of pathways shared by a signature hub from the Wang dataset and a signature hub from the Desmedt dataset (2010, NA)
• Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice (2010, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Structural Analysis to Determine the Core of Hypoxia Response Network (2010, Homo sapiens,Caenorhabditis elegans)
• Schematic summary of effect of IL-4 priming on phagocytic and secretory capacities of MΦs (2010, Mus musculus,Neisseria meningitidis,Homo sapiens)
• The effects of SOX4 and HOXC6 on Notch pathway activation and metastasis (2010, Homo sapiens)
• The effects of the SOX4 and HOXC6 transcriptional networks on PI3K-AKT pathway activation in prostate cancer (2010, Homo sapiens)
• Reversible phosphorylation regulation of the cell cycle (2010, Caenorhabditis elegans,Homo sapiens)
• Mammalian target of rapamycin (mTOR) activation pathway (2010, Caenorhabditis elegans,Homo sapiens)
• Summary of the insulin/IGF signaling pathway, using the terminology for mammalian systems (2010, Caenorhabditis elegans,Homo sapiens)
• Signaling pathway regulating Nogo-A expression in DRG neurons (2010, Rattus norvegicus,Homo sapiens)
• Summary of the AMPK and mTOR signaling pathways (2010, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Hh and Wnt signaling pathways (2010, NA)
• TGFB superfamily and FGF signaling pathways (2010, NA)
• TLR4 signaling pathway can be activated via GAG fragments requiring CD44 and MyD88 or through LPS, which requires MyD88, LBP, and CD14 (2010, NA)
• Inflammatory Mediator TAK1 Regulates Hair Follicle Morphogenesis and Anagen Induction Shown by Using Keratinocyte-Specific TAK1-Deficient Mice (2010, Homo sapiens,Mus musculus)
• Mu-Opioid Receptors Transiently Activate the Akt-nNOS Pathway to Produce Sustained Potentiation of PKC-Mediated NMDAR-CaMKII Signaling (2010, NA)
• Model shows the simplified NF-kB signaling pathway that is activated by oxidative stress (2010, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Bos taurus,Escherichia coli,Human immunodeficiency virus 1,Calloplesiops altivelis)
• Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks (2010, Homo sapiens,Saccharomyces cerevisiae,Acanthamoeba polyphaga mimivirus)
• Working model of TGFB actions in renal interstitial fibrogenesis (2010, Rattus norvegicus,Homo sapiens)
• Galectins, integrins and cell migration (2010, NA)
• Integrin trafficking and endoplasmic reticulum (ER) to Golgi protein export pathways.A (2010, NA)
• Ligand binding and subsequent Erbb dimer formation initiates signaling through a complex array of intracellular pathways that initiate and control a range of cellular processes (2010, Homo sapiens)
• Regulation of C (2010, NA)
• The signaling pathways regulating osteoblast-like cells proliferation in response to OSS (2010, Homo sapiens)
• IR and IGF family signaling pathway (2010, Homo sapiens,Mus musculus)
• Signaling by the sst2A receptor upon activation by different somatostatin analogs (2010, NA)
• Snapshots from the integrated macrophage pathway diagram (2010, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis,Syringa vulgaris)
• Schematic presentation of Nrf2-ARE pathway (2010, Panax ginseng,Angelica sinensis,Panax quinquefolius,Mus musculus,Rattus norvegicus,Homo sapiens,Schaalia meyeri)
• Signaling through the Lymphocyte receptor induces a novel regulatory motif for MAP kinase activation (2010, Oryctolagus cuniculus,Capra hircus,Mus musculus,Homo sapiens)
• Overlay of IfnB timecourse analysis onto the macrophage pathway using BioLayout Express3D (2010, Homo sapiens,Mus musculus,Venustaconcha ellipsiformis,Syringa vulgaris)
• Proposed revised model of mammalian DNA damage response (2010, Mus musculus,Homo sapiens)
• TLR signaling upon intrinsic cellular defenses (2010, Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Mouse mammary tumor virus,Dengue virus,Respiratory syncytial virus,Human betaherpesvirus 5,Vaccinia virus,West Nile virus,Measles morbillivirus,Encephalomyocarditis virus,Sindbis virus,Thogotovirus thogotoense,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Danio rerio,NA,NA)
• New roles for Notch in tuberous sclerosis (2010, NA)
• Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling (2010, NA)
• Schematic model of SAPK-induced Foxo3a nuclear export in muscle cells (2010, NA)
• Apoptosis Signalling network (2010, Homo sapiens,Mus musculus)
• Regulation of TM by the PDGFR axis in bladder smooth muscle (2010, NA)
• Working model for ARF6-GTP-induced signaling during cyst development (2010, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Danio rerio)
• Proposed mechanism for pathogenesis due to H (2010, Helicobacter pylori)
• “Where, O Death, Is Thy Sting?” A Brief Review of Apoptosis Biology (2010, NA)
• PARP in the repair of single-strand DNA breaks via the base excision repair pathway (2010, NA)
• Pathway induction after pathophysiologic stimulation of BSMC by three coordinate stimuli: strain, hypoxia, and damaged matrix (2010, Homo sapiens,Rattus norvegicus,Bos taurus)
• Stages of apoptotic cell engulfment and associated cell signaling events that regulate each stage (2010, NA)
• Ingenuity Pathway Assist (IPA) analysis of significant genes involved in cell death (2010, NA)
• Reconstructed CCM of S (2010, NA)
• FGF-receptor signalling in the generation of hindbrain neural cell diversity (2010, NA)
• Schematic drawing of Akt/GSK-3B/tau signaling (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• Loss of RB function triggers CIN by several mechanisms (2010, NA)
• Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics (2010, NA)
• Proposed cell-signaling cascade underlying the enhancement of contextual fear conditioning by nicotine (2010, NA)
• O-GlcNAc and phosphate regulate the insulin signaling pathway at the plasma membrane (2010, NA)
• AKAP-Lbc integrates multiple signaling pathways (2010, NA)
• Simplified scheme of pro-inflammatory signal transduction pathways leading to eNOS activation and endothelial hyperpermeability (2010, NA)
• Mode of miRNAs that regulate adipogenesis by modulating the canonical Wnt/Beta-catenin signaling pathway (2010, NA)
• Light-induced activation of PI3K (2010, NA)
• Signaling pathway downstream of PI3K affect cell death and cell survival (2010, NA)
• Signaling pathway of the KRAS protein (2010, Mus musculus,Rattus norvegicus,Avian leukosis virus,Kirsten murine sarcoma virus,Homo sapiens,Caenorhabditis elegans,Gallus gallus,Nicotiana tabacum)
• Placing datasets into a functional context using pathway analysis (2010, unidentified influenza virus,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,Ebola virus,Enterovirus C,Lyssavirus rabies,Variola virus,Rift Valley fever virus,African swine fever virus,Vaccinia virus LC16M8,Mus musculus,Cavia porcellus,Peromyscus maniculatus,Homo sapiens,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Macaca mulatta,Bacillus anthracis,Marinobacter nauticus,Sus scrofa domesticus,NA,NA,NA,NA,NA,NA,NA,NA)
• Metabolic pathway map constructed using the E-Cell RBC model (2010, Mus musculus,Callospermophilus lateralis,Homo sapiens,Ovis aries,Euphilotes enoptes,Zoysia japonica)
• Schematic overview of MAPK-regulated processes that are thought to couple light to the SCN clock during the early night (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Armoracia rusticana,Doodia media,Homo sapiens,Xenopus laevis,NA)
• TLR4 and chemokine receptor cross-talk (2010, Human gammaherpesvirus 4,Orthomyxoviridae,Vesicular stomatitis virus,Japanese encephalitis virus,Encephalomyocarditis virus,Mengo virus,Mus musculus,Rattus norvegicus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Sus scrofa,NA,NA)
• TLR signaling (an example in macrophages and dendritic cells) (2010, Human gammaherpesvirus 4,Orthomyxoviridae,Vesicular stomatitis virus,Japanese encephalitis virus,Encephalomyocarditis virus,Mengo virus,Mus musculus,Rattus norvegicus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Sus scrofa,NA,NA)
• Regulatory network that links the activities of an ensemble of transcriptional regulators, signaling components and survival factors in developing B cells into a common pathway (2010, Saccharomyces cerevisiae,Helianthus annuus,Homo sapiens,Mus musculus,Drosophila melanogaster,Tragelaphus oryx)
• Current model of the ACE2 signaling pathway involved in SARS-CoV-induced CCL2 expression (2010, NA)
• Overlay of predicted functional interactions onto a human curated GBM pathway from the TCGA data set (2010, NA)
• N‐linked glycosylation (2010, NA)
• RTK activation (2010, NA)
• Cell adhesion pathway and ECM–receptor interaction pathways are affected by RCT (2010, Homo sapiens)
• Leukocyte transendothelial migration pathway is affected by RCT (2010, Homo sapiens)
• Schematic pathway of IL-8-mediated NAADP formation by CD38 in LAK cells (2010, NA)
• Hippo signaling restrains Yki-accelerated cell division in response to injury (2010, Drosophila melanogaster,Homo sapiens)
• Schematic model for the regulation of stability of platelet aggregation in response to thrombin (2010, NA)
• Rapid progress for non-nuclear estrogen receptor signaling (2010, NA)
• Biosynthetic pathway of GA (2010, NA)
• Inflammation Stages in the Acute Lung Injury in Mice (2010, NA)
• Genome Erosion in a Nitrogen-Fixing Vertically Transmitted Endosymbiotic Multicellular Cyanobacterium (2010, Escherichia coli,Synechocystis sp. PCC 6803,Synechocystis sp.,Nostoc sp. PCC 7120 FACHB-418,Escherichia coli DH1,Nostoc punctiforme,Nostoc punctiforme PCC 73102,Cylindrospermopsis raciborskii,Trichormus variabilis ATCC 29413,Wigglesworthia glossinidia,Plasmid P1,Cylindrospermopsis raciborskii CS-505,Raphidiopsis brookii D9,Arabidopsis thaliana,Embryophyta,PX clade,Magnoliopsida,Cycadophyta,Azolla filiculoides,Azolla microphylla,Azolla caroliniana,NA)
• CXCR4 pathway is affected in CD34+ cells from CAD patients (2010, NA)
• Putative signaling components in fungal mating interactions (2010, NA)
• Intracellular signal transduction pathways that have been proposed to be involved in macrolide immunomodulation (2010, NA)
• Modeling Dose-response at Low Dose: A Systems Biology Approach for Ionization Radiation (2010, NA)
• Xs and Y of immune responses to viral vaccines (2010, NA)
• II S and TOR-signaling pathway in Drosophila (2010, Drosophila melanogaster,Homo sapiens)
• NFKB and tumor-associated macrophages (2010, Homo sapiens,Mus musculus,Human papillomavirus type 16,Helicobacter hepaticus)
• The Regulation of the CNS Innate Immune Response Is Vital for the Restoration of Tissue Homeostasis (Repair) after Acute Brain Injury: A Brief Review (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,prion)
• Hepatocyte Growth Factor Modulates Interleukin-6 Production in Bone Marrow Derived Macrophages: Implications for Inflammatory Mediated Diseases (2010, NA)
• TLR signalling (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• VEGF signaling interactions (2010, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Homo sapiens)
• Two potential grounds for attenuation of IFN‐B bioactivity by statins (2010, Homo sapiens)
• DNA damage response (DDR) pathway (2010, NA)
• Hsp90-dependent modulation of proangiogenic signaling pathways in cancer (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Panthera tigris,NA)
• Putative model for mechanism of rotavirus NSP1-mediated proviral function (2010, NA)
• Circadian rhythms and memory formation (2010, NA)
• Model figure for B-RAF inhibitor-mediated activation of the C-RAF/MEK/ERK pathway in non-mutant B-RAF melanoma cells (2010, Homo sapiens,Mus musculus,NA)
• HMG-CoA reductase pathway (2010, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Putative mechanisms underlying the protection of dopaminergic substantia nigra pars compacta (SNc) neurones following group III metabotropic glutamate (mGlu) receptor activation (2010, Homo sapiens,Mus musculus,Rattus norvegicus,Saimiri sciureus,Xenopus laevis)
• Glucose metabolic pathway response (2010, Saccharomyces cerevisiae,Homo sapiens)
• Cell signaling model for the regulation of glucose metabolism in hepatocytes by taurocholate (2010, Mus musculus,Rattus norvegicus,Vesicular stomatitis virus,Papaya ringspot virus,Homo sapiens,Armoracia rusticana)
• Proposed model for the role of iPLA2B in mitochondrial function (2010, Mus musculus,Homo sapiens)
• TLR signalling pathways: All TLRs except TLR3 share a common initial signalling pathway through MyD88 to the IRAK1/2/4TRAF6 complex (2010, NA)
• Concurrent deregulation of the top five canonical pathways in retinoblastoma (RB) tumors (2010, Homo sapiens,Mus musculus,Sequoia sempervirens,clinical samples,NA)
• The signaling pathway mediated by GABAB receptor in CGN neuroprotection (2010, Mus musculus,Homo sapiens)
• Proposed mechanism involved in pathological NO-induced synapse elimination (2010, Rattus norvegicus,Homo sapiens)
• B2-Adrenergic receptor desensitization in perirenal adipose tissue (2010, NA)
• Signaling pathways for epi activation of secretion (2010, Cavia porcellus,Homo sapiens)
• Hypoxia-inducible factor (HIF)-2 regulates erythropoietin (EPO) (2010, NA)
• Erythropoietic regulation by an iron-aconitase-isocitrate pathway (2010, NA)
• Integration of oncogenic and tumor suppressor inputs by the GLI code in cancer (2010, NA)
• Sno Oncogene Antagonizes Wingless Signaling during Wing Development in Drosophila (2010, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Capra hircus,Cavia porcellus,Matthiola incana,Papio anubis,Drosophila melanogaster,Gallus gallus)
• Ubiquitin/26S proteasome system (UPS) (2010, NA)
• Suppression of IFN-induced Jak-STAT signaling in hepatitis C (2010, NA)
• Simplified TGFB signaling pathways (2010, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Mus musculus)
• Progressive inactivation of GSK3B may promote increased anti-apoptosis and oral cancer (2010, NA)
• Inflammatory microenvironment provokes metaplasia in Barrett’s esophagus by several mechanisms (2010, NA)
• Targeting GSK3B pathway may be highly beneficial for curing oral cancer (2010, NA)
• Type I IFN Signaling (2010, Human immunodeficiency virus 1,Vaccinia virus,Moloney murine sarcoma virus,Rauscher mink cell focus-forming virus,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Diaporthe sclerotioides,Antarctothoa delta,NA)
• F igure 1.— (2010, NA)
• Inhibition of host signalling pathways by VACV members of A46 and related families (2010, NA)
• Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathways (2010, Mus musculus,Rattus norvegicus,Escherichia coli,bacterium 2-4B,Homo sapiens,Moloney murine leukemia virus)
• Proposed integrated signaling pathway responsible for the synergistic chemotactic responses elicited by antigen in the presence of SCF or GPCR agonists (2010, Mus musculus,Homo sapiens)
• The intracellular signaling network regulating T-cell trafficking and differentiation (2010, NA)
• Sirtuin 3, a New Target of PGC-1A, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Pan troglodytes,Saccharomyces cerevisiae,unidentified shuttle vector)
• Elucidating the CXCL12/CXCR4 Signaling Network in Chronic Lymphocytic Leukemia through Phosphoproteomics Analysis (2010, NA)
• Olfactory sensory neuron projections along the anterior–posterior axis in the mouse olfactory system (2010, NA)
• Pathways regulating Leydig cell division activated by soy isoflavones (2010, NA)
• PI3K dependent signal pathway (2010, NA)
• Cytokine signaling through the Jak/Stat pathway in mammary gland development (2010, Mus musculus,Homo sapiens)
• Signal Response Sensitivity in the Yeast Mitogen-Activated Protein Kinase Cascade (2010, NA)
• Action for AICAR in human retinoblastoma cells (2010, Homo sapiens)
• PAR1 and PAR2 signaling involves MAPK and PI3K signaling pathways in the induction of innate immune responses (2010, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Homo sapiens,Antarctothoa delta)
• Probiotics modulate key signaling pathways in intestinal epithelial cells (2010, NA)
• TGRB signaling during liver regeneration (2010, NA)
• Pathway analysis on differentially expressed genes (2010, Homo sapiens,Mus musculus)
• RSK signaling pathway (2010, NA)
• Protein-protein interaction comprising the transforming growth factor B signaling pathway (2010, NA)
• Protein-protein interaction maps comprising the transforming growth factor B signaling pathway of transcription factors associated with liver cell proliferation (2010, NA)
• Oxidative stress-Chronic stress cycle of aging (2010, NA)
• Absence of Inhibin Alpha and Retinoblastoma Protein Leads to Early Sertoli Cell Dysfunction (2010, NA)
• RNA-Seq Analysis of Sulfur-Deprived Chlamydomonas Cells Reveals Aspects of Acclimation Critical for Cell Survival (2010, Chlamydomonas reinhardtii)
• PI3K/Akt/mTOR signaling pathway (2010, NA)
• The signaling pathway of ApNHE3 activation upon oocyte spawning (2010, NA)
• In adult worms the FGFR EGL-15(5A) targeted for activation by the Klotho KL1 isoform can allow EGL-17 ligand binding (2010, Caenorhabditis elegans,Homo sapiens)
• Glucose uptake in adipose tissue and its regulation by ghrelin (2010, NA)
• Reciprocal inhibition mechanism by TGFB and IFNG (2010, Mus musculus,Homo sapiens)
• Selection of miRNA implicated in the TLR4 signalling pathway (2010, NA)
• Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells (2010, Homo sapiens,Mus musculus)
• PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001 (2010, Homo sapiens)
• Tumor suppressor pathways control Mdm2 function (2010, Homo sapiens)
• NFKB activation pathways (2010, NA)
• Schematic overview of Toll-like receptor (TLR)4 signaling pathway (2010, NA)
• Generation of a biological network of genes of the most significant Canonical Pathways for the EF·CIF (Il10-/- vs (2010, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Enterococcus faecium,bacterium 1-7A,Armoracia rusticana,Matthiola incana,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Generation of a biological network of genes of the most significant Canonical Pathways for the Il10-/- (EF·CIF vs (2010, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Enterococcus faecium,bacterium 1-7A,Armoracia rusticana,Matthiola incana,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Chemoreception Regulates Chemical Access to Mouse Vomeronasal Organ: Role of Solitary Chemosensory Cells (2010, Bos taurus,Equus asinus,Mustela putorius furo,Monodelphis domestica,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Matthiola incana,Cricetus cricetus,Citrus x paradisi,Merluccius merluccius,Necturus maculosus,Homo sapiens,Streptomyces griseus)
• Interconnected pathways that cause bone marrow failure (2010, NA)
• Cross talk of the Nodal/Cripto-1 signaling pathway with Wnt, hypoxia, Notch, Oct-4, and Nanog signaling pathways (2010, NA)
• Signaling model for the effect of morphine on hypoxia-induced HIF-1A (2010, NA)
• Top network of metastasis virulence biomarkers (Ingenuity Pathway Analysis Knowledge Base) (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,Sequoia sempervirens)
• Top network depicting the influence of high fat diet on mammary tumor gene expression (Ingenuity Pathway Analysis Knowledge Base) (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,Sequoia sempervirens)
• E-selectin–mediated slow rolling (2010, Mus musculus,Homo sapiens)
• Schematic model of crosstalk between PPARG and Wnt-5a signaling in MSC (2010, Mus musculus,Homo sapiens)
• Gene Chip analysis reveal SOX11-induced regulation of Rb-E2F and TGFB signaling pathways (2010, NA)
• Pathway packaging of the 'biopolymer metabolic process' module (2010, NA)
• Identification of RON-targeting genes (2010, NA)
• Model showing the interorganellar flow of acetyl units in C (2010, Candida albicans)
• Proposed asukamycin biosynthetic pathway (2010, Streptomyces lividans,Streptomyces nodosus subsp. asukaensis)
• Met RTK down-regulation through dorsal ruffles (2010, Canis lupus familiaris,Homo sapiens)
• Metalloproteinase-dependent cross-talk between the PDGFRB and the EGFR/ERK1/2 signaling pathway (2010, NA)
• New model for a novel role of p38 MAPK in the DNA damage response in cancer cells (2010, NA)
• Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis (2010, NA)
• Proposed model for the role of NOX4 and DUOX2 in promoting cell cycle entry (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Pathways of biosynthesis of O-glycans in normal and cancer breast epithelial cells (2010, Glycine max,Arachis hypogaea,Amaranthus caudatus,Salvia sclarea,Griffonia simplicifolia,Vigna unguiculata subsp. cylindrica,Vicia villosa,Azara integrifolia,Mus musculus,Rattus norvegicus,Patella vulgata,Helix pomatia,Homo sapiens,Canis lupus familiaris,Human immunodeficiency virus 2)
• Molecular pathway initiated by P4 signaling in BPBC cells (2010, NA)
• Toll-like receptor signaling pathway (2010, Homo sapiens)
• ACE inhibitors, ARB and Statins act effectively as antioxidants to inhibit inflammatory and growth pathways (2010, NA)
• Analysis of gene expression in CD44+/CD24− MCF-7/ADR cell population by TaqMan Low-Density Array and Ingenuity Pathway analysis (2010, NA)
• DNA Damage Response (DDR) pathways in normal and malignant cells (2010, Homo sapiens)
• In Vino Veritas (2010, NA)
• Thalidomide bypasses the requirement of the TGFB1–endoglin–Alk-1 signaling pathway for vascular stability (2010, Homo sapiens,Mus musculus,Danio rerio)
• Intracellular signaling of FIP1L1/PDGFRA+ (F/P) cells (2010, Homo sapiens,Mus musculus)
• HIF-1A and HIF-2A have different functions in the cartilage (2010, NA)
• Comparative Analysis of Extra-Embryonic Endoderm Cell Lines (2010, Gallus gallus,Xenopus laevis,Coturnix coturnix,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• PDC113.824-mediated biased signaling effects through FP receptor (2010, Homo sapiens,Mus musculus)
• LPA signaling in osteoclasts (2010, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Homo sapiens)
• Targeting HIF activation pathway for cancer therapy (2010, Homo sapiens,Gallus gallus)
• Canonical and non-canonical signaling pathways of the AhR (2010, NA)
• Spatial-temporal signals determine the fate of activated CD8+ T cells (2010, Homo sapiens,Human papillomavirus,NA)
• Growth factor signaling pathways mediating survival in multipotential stromal cells (2010, NA)
• Molecular networks over-represented by E (2010, Eimeria bovis,Homo sapiens)
• Adenosine monophosphate-activated protein kinase pathway in hepatic fuel metabolism (2010, NA)
• Dual regulation of fuel metabolism and cell viability by adenosine monophosphate-activated protein kinase (2010, NA)
• Growth factor signaling pathways mediating proliferation in multipotential stromal cells (2010, NA)
• N- and C-terminal cleavage of the PC1 protein (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Xenopus laevis)
• Biology of the von Hippel-Lindau/hypoxia-inducible factor (VHL-HIF) axis in the setting of hypoxia or a mutation or aberration of the VHL gene product (2010, Homo sapiens,Mus musculus)
• Rituximab-mediated cell death (2010, Homo sapiens)
• Reverse-Phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells (2010, NA)
• Common signaling pathways in inflammation and cancer including those regulating ARE-gene expression and mRNA stability (2010, NA)
• Postconditioning against ischaemia-reperfusion injury: ready for wide application in patients? (2010, Homo sapiens)
• Conserved ATR→CHK1 checkpoint signaling pathway in eukaryotes (, ) (2010, NA)
• Schematic for DSB repair by HR and NHEJ pathways (2010, Homo sapiens)
• TGFB canonical signal transduction pathway and transcriptional responses mediating TGFB growth inhibitory effects (2010, NA)
• Paracrine-mediated tumor enhancement and maintenance of glioma heterogeneity (2010, Homo sapiens,Mus musculus)
• Schematic illustration depicting the cellular pathways that lead to eIF4E activation and phosphorylation by Mnk1/2 (2010, NA)
• Gene expression profiling in whole blood of patients with coronary artery disease (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,clinical samples)
• Hybrid Models Identified a 12-Gene Signature for Lung Cancer Prognosis and Chemoresponse Prediction (2010, NA)
• Anisotropic regulation of Ankrd2 in the diaphragm muscle (2010, NA)
• Wnt signaling pathways (2010, NA)
• Human erythrocyte metabolism modeled using detailed enzyme rate equations (2010, Mus musculus,Rattus norvegicus,Bacillus subtilis,Bacillus subtilis At2,Homo sapiens,Saccharomyces cerevisiae)
• Network view of associated proteins created within Ingenuity Pathway Analysis software for visualizing molecular interrelationships (2010, NA)
• Role of the N-end rule pathway in RGS protein degradation (2010, Homo sapiens)
• Model for C (2010, NA)
• Signaling events involved in PKCE-mediated survival in LNCaP cells (2010, Homo sapiens)
• Examination of Apoptosis Signaling in Pancreatic Cancer by Computational Signal Transduction Analysis (2010, Homo sapiens,Mus musculus)
• Model for phosphoinositide-3-kinase (PI3K)-dependent opponent input to rodent olfactory receptor neurons (ORNs) (2010, Homo sapiens)
• BMP signal transduction (2010, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Bombyx mori)
• Polarization and guidance in neurons (2010, NA)
• Directed cell migration (2010, NA)
• Proposed model for dysregulated mGluR signaling in FXS (2010, NA)
• P-values for testing association of the genes within the MAPK signaling pathway with RA in WTCCC studies (2010, Homo sapiens,Mus musculus)
• P-values for testing association of the genes within the MAPK signaling pathway with RA in NARAC studies (2010, Homo sapiens,Mus musculus)
• The IFN-λ receptor signaling pathway (2010, NA)
• Competing Activities of Heterotrimeric G Proteins in Drosophila Wing Maturation (2010, NA)
• Molecular pathways involved in pancreas and liver differentiation from hES cells (2010, Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis,Plasmid pTF1)
• Insulin signaling pathway from PathVisio (2010, NA)
• Plastids play a central role in the generation of wounding and herbivory induced signals (2010, NA)
• Wnt signaling pathway (2010, NA)
• Schematic diagram for the role of Glrx1 in regulation of IKKA and IKKB in response to CS (2010, NA)
• Overview of autophagy (2010, NA)
• The PA-mediated activation of mTORC1 signaling (2010, NA)
• Schematic diagram of the interaction of HH signalling on p53 and Nanog (2010, Mus musculus,Homo sapiens)
• pH as the glucose signal (2010, NA)
• Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity (2010, Lareunionomyces loeiensis,Olea europaea,Arachis hypogaea,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Trypanosoma cruzi)
• HER/HER2-PI3K-Akt-NFKB-elicited pathway in prostate cancer cells (2010, Homo sapiens)
• Examples of the inter-relationship between host, tumor, and environmental factors (pharmaco-epi-bio-genomic triad) that determine the response to tamoxifen in an individual patient (phenotype) (2010, NA)
• Signaling pathway and transcription factors involved in HPR1 gene expression in cancer (2010, NA)
• Refined model of the ERK signaling network (2010, NA)
• Daphnia pulex insulin and TOR signalling pathways, adapted from Drosophila melanogaster (2010, Drosophila melanogaster,Daphnia pulex,Homo sapiens)
• Protein-protein interaction map of Notch transcription modifiers (2010, Saccharomyces cerevisiae,Eucalyptus intertexta,Iris germanica,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Gene expression within cluster MCL2 is enriched in genes affecting NK cell-mediated cytotoxicity (2010, Chlamydia trachomatis,Homo sapiens)
• Hypothetical model for EGFR-dependent loss of cell polarity and activation of Wnt signaling in CS-exposed human airway epithelium (2010, Homo sapiens,Nicotiana tabacum)
• Nitrogen Control of Virulence Functions in F (2010, Fusarium oxysporum)
• Suppression of uPA and uPAR Attenuates Angiogenin Mediated Angiogenesis in Endothelial and Glioblastoma Cell Lines (2010, Homo sapiens,Mus musculus,Escherichia coli)
• Defects in physiologically driven actin signaling at hippocampal synapses in Fmr1-KO mice (2010, NA)
• cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways (2010, NA)
• Mapping Drug Physico-Chemical Features to Pathway Activity Reveals Molecular Networks Linked to Toxicity Outcome (2010, Homo sapiens,Rattus norvegicus)
• Schematic diagram depicting signalling pathway in the follicle after LH peak leading to the resumption of meiosis in oocytes (2010, Homo sapiens,Mus musculus)
• MAPK Signaling Pathway (2010, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Changes in gene expression in central carbon metabolism (A) and ergosterol synthesis (B) (2010, Candida albicans)
• Transport of heme synthesis intermediates and heme in metazoans (2010, NA)
• Metabolic signaling pathway of candidate pathway (2010, NA)
• Gene pathway analysis (2010, NA)
• Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development (2010, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Agaricus bisporus,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• Diversity and Plasticity of Th Cell Types Predicted from Regulatory Network Modelling (2010, NA)
• Gradient Descent Optimization in Gene Regulatory Pathways (2010, Escherichia coli,Escherichia coli K-12,Escherichia coli IS1,Escherichia coli str. K-12 substr. W3110,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 4,NA)
• Gradient Descent Optimization in Gene Regulatory Pathways (2010, Escherichia coli,Escherichia coli K-12,Escherichia coli IS1,Escherichia coli str. K-12 substr. W3110,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 4,NA)
• REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy (2010, NA)
• Rapid Diversification of Cell Signaling Phenotypes by Modular Domain Recombination (2010, NA)
• Gradient Descent Optimization in Gene Regulatory Pathways (2010, Escherichia coli,Escherichia coli K-12,Escherichia coli IS1,Escherichia coli str. K-12 substr. W3110,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae,Human gammaherpesvirus 4,NA)
• p-mTOR triggers progression of the cells to G1 phase of the cell cycle (2010, NA)
• Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications (2010, NA)
• Proposed model of epidermal growth factor receptor (EGFR) aberrant activation and trafficking in the setting of cigarette smoke (CS) (2010, NA)
• The canonical Wnt signaling pathway (2010, NA)
• EGFR signaling and NHEJ (2010, NA)
• Genistein inhibits critical pathways in cancer invasion (2010, Nicotiana tabacum,Zea mays,Glycine max,Genista tinctoria,Calluna vulgaris,Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Betapolyomavirus macacae)
• Distinct functions for TPPII in the nucleus and cytosol (2010, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Human immunodeficiency virus 1,Schizosaccharomyces pombe,unidentified influenza virus,Cricetulus griseus,Murid betaherpesvirus 1,Homo sapiens,Drosophila melanogaster,Caenorhabditis elegans,Macaca fascicularis,Oryctolagus cuniculus,Listeria monocytogenes,NA)
• Regulation of survival pathways by mutant B-RAF (2010, NA)
• Activation of NFKB by the PI3K/AKT and MAPK pathways (2010, NA)
• Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where carbon-limiting medium is changed to nitrogen-limiting medium at time zero (2010, Escherichia coli,Escherichia coli str. K-12 substr. MG1655,Klebsiella aerogenes,Escherichia coli str. K-12 substr. W3110,Escherichia coli O2H1,Saccharomyces cerevisiae,Hordeum vulgare,Iris germanica,Cricetulus griseus,Cyprinus carpio,Homo sapiens)
• Fluxmap of the glycolysis, penthose phosphate pathway, and citric acid cycle for the experiment where nitrogen-limiting medium is changed to carbon-limiting medium at time zero (2010, Escherichia coli,Escherichia coli str. K-12 substr. MG1655,Klebsiella aerogenes,Escherichia coli str. K-12 substr. W3110,Escherichia coli O2H1,Saccharomyces cerevisiae,Hordeum vulgare,Iris germanica,Cricetulus griseus,Cyprinus carpio,Homo sapiens)
• The highly simplified PI3K/Akt and MAP kinase pathways in thyroid cancer (2010, NA)
• The PI3K/Akt and MAP kinase pathways driven by the increasing accumulation of genetic alterations in the progression from low-grade to high-grade thyroid cancers (2010, NA)
• Schemes of the opposing responses of p53 after lupulone treatment in SW620 and SW480 cells (2010, NA)
• GRK2 interactome involved in cell migration (2010, NA)
• GRK2 interactome involved in the modulation of cell cycle progression (2010, NA)
• The inhibitory effect of metformin in PMA-induced migration and invasion (2010, Homo sapiens)
• The Lrp5-dependent regulation of bone formation through inhibition of tph1 expression and 5-HT synthesis in enterochromaffin cells (2010, Homo sapiens)
• Hypothetical scheme highlighting the potential roles of mitochondrial morphology in cardiovascular disease with factors promoting mitochondrial fission on the left of the figure and factors promoting mitochondrial fusion on the right of the figure (2010, NA)
• RIG-I signalling pathway (2010, NA)
• Proposed model for the action of both profilin isoforms in different neuronal compartments (2010, Homo sapiens,Mus musculus)
• Signaling pathways described in ARPE19 cells (2010, Rattus norvegicus,Homo sapiens)
• The phosphatase calcineurin in the Beta-adrenergic signaling pathway via regulation of PDE4D degradation (2010, NA)
• TNF/Fas/TRAIL signaling pathway (2010, NA)
• Connections of literature-completed interactome of PI3K-mTOR pathway with other signaling pathways (2010, NA)
• Metabolic model used for 13C-MFA (2010, NA)
• Comparison of fluxes of central carbon metabolism determined by MFA and predicted from a genome-scale metabolic model (2010, NA)
• Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis (2010, NA)
• Proposed signaling pathway by which all three PPAR isoforms exert anti-apoptotic actions via 14-3-3E upregulation (2010, NA)
• mTOR-independent pathway, with multiple drug targets acting at various places in this pathway that induce autophagy (2010, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Danio rerio)
• Current model of early symbiotic signaling pathways (2010, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Glycine max,Solanum lycopersicum,Medicago truncatula,Pisum sativum,Medicago sativa,Vicia faba,Lotus japonicus,Lilium longiflorum,Sinorhizobium meliloti,Bradyrhizobium japonicum,Azotobacter vinelandii,Rhizobium leguminosarum,Mesorhizobium loti,Homo sapiens,Cauliflower mosaic virus)
• Actin-cytoskeleton signaling pathway and the candidate genes involved in colorectal cancer progression in patients with ulcerative colitis (2010, Homo sapiens)
• Pfn gene neighborhood and its interacting pathway (2010, Homo sapiens)
• Domain organization of proteins in the Hh signaling pathway (2010, NA)
• Proposed inhibitory mechanisms of SOCS1 on TLR signaling (2010, NA)
• Molecular interactomes and sub-networks associated with tumor cell susceptibility to arsenic trioxide (2010, NA)
• Complement/Coagulation pathway activation (2010, NA)
• The three-tiered MAPK cascades (Adapted from Luster et al (2010, NA)
• Model outlining the LDCV/nuclear signaling pathway in which PAM and Uhmk1 participate (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• LHR signaling to cofilin (2010, Rattus norvegicus,Homo sapiens)
• Schematic model of LH/hCG-mediated mTORC1 signaling in T-I cells (2010, Homo sapiens,Rattus norvegicus)
• Schematic overview of the canonical Notch signaling pathway (2010, NA)
• Pioglitazone positively affects the insulin signaling system resulting in improved glycemic control, generation of nitric oxide and decreased MAP kinase pathway activation (2010, NA)
• Toll-like receptor (TLR) signalling is mediated by at least two distinct pathways (2010, Helicobacter pylori,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus,Drosophila melanogaster,Human papillomavirus)
• Proposed scheme of the molecular mechanism underlying LPCAT2 activation (2010, NA)
• Visualization of the pyruvate metabolism before and during H2 production (2010, NA)
• Ulk3 function in Shh signaling pathway (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hypothesized signal pathway that Mtmr8 regulates artery specification and hematovascular progenitor specification in zebrafish embryo (2010, NA)
• Convergence between Wnt and EGFR pathways (2010, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Mouse mammary tumor virus)
• Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence (2010, NA)
• Gene Expression Study of Monocytes/Macrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts (2010, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathways and networks related to chondrocyte proteins identified by proteomics as altered by GS and/or CS (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Armoracia rusticana)
• Glucose metabolism in mammalian cells (2010, NA)
• Complement cascade is comprised of the Classical, Alternative, and Mannose Binding Lectin pathways (2010, NA)
• Central metabolic network of glycerol in wildtype E (2010, Escherichia coli)
• TLR7/9 Signaling pathway leading to the production of proinflammatory cytokines and type I IFN (2010, NA)
• Cancer signaling pathways affected within the tumor (2010, Homo sapiens,clinical samples)
• BCR signaling pathway (2010, NA)
• 抗表皮生长因子受体和抗血管内皮生长因子药物在非小细胞肺癌治疗中的作用 (2010, NA)
• 在SCLC中，受体酪氨酸激酶及其配体通常呈过表达状态。缺陷性受体酪氨酸激酶及它们各自的生长因子包括：VEGFR/VEGF, c-Kit/SCF, c-MET/HGF, FGFR/FGF以及IGF-1R/IGF。通过多种通路的激活，包括在SCLC中失调的PI3K/AKT/mTOR通路，在存活、凋亡、细胞周期调节和翻译过程中发挥作用。Receptor tyrosine kinases and their known ligands are often overexpressed in SCLC (2010, NA)
• ERBB signaling pathway (2010, NA)
• 小细胞肺癌的的分子发病机制 (2010, NA)
• Moral graph Dm obtained from BCR pathway (2010, NA)
• Triangulated graph Dt obtained from BCR pathway (2010, NA)
• Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim (2010, NA)
• The mitochondrial fatty acid beta-oxidation pathway (2010, Bos taurus,Sus scrofa,Homo sapiens,Rattus norvegicus)
• Immunology of resolving infection and disease progression to Leishmania For both T helper 1 (TH1)- and TH2-cell differentiations, antigens are presented to naive CD4+ T cells by dendritic cells (DCs) (2010, Leishmania major,Leishmania donovani,Leishmania mexicana,Leishmania infantum,Leishmania braziliensis,Leishmania tropica,Leishmania aethiopica,Human immunodeficiency virus 1,Human immunodeficiency virus,Simian immunodeficiency virus,Homo sapiens,Macaca mulatta,Simian-Human immunodeficiency virus,Simian-Human immunodeficiency virus 1,Mus musculus)
• Regulation of adipogenesis by canonical Wnt signaling cascade (2010, Homo sapiens)
• MyD88-induced protein accumulation pathways through SQSTM1 and HDAC6 (2010, NA)
• Proposed mGluR6-signaling cascade in rod bipolar cells (2010, NA)
• Network Analysis of Enzyme Activities and Metabolite Levels and Their Relationship to Biomass in a Large Panel of Arabidopsis Accessions (2010, Arabidopsis thaliana)
• The signaling transduction pathway leading to tPA induced fibroblast proliferation (2010, Mus musculus,Rattus norvegicus,Homo sapiens)
• The role of PDGF signaling in the PrE lineage of the mouse blastocyst (2010, Homo sapiens,Mus musculus)
• Genome of a Pathogenic Rhodococcus: Cooptive Virulence Underpinned by Key Gene Acquisitions (2010, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Mycobacterium tuberculosis variant bovis BCG,Streptomyces coelicolor,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Bifidobacterium longum,Actinomycetia bacterium,Corynebacterium diphtheriae,Brucella suis,Rhodococcus opacus,Rhodococcus jostii RHA1,Rhodococcus erythropolis,Prescottella equi,Rhodococcus jostii,Listeria ivanovii,Tropheryma whipplei,Nocardia farcinica,Rhodococcus pyridinivorans,Rhodococcus erythropolis PR4,Paenarthrobacter aurescens TC1,Nocardia farcinica IFM 10152,Clavibacter michiganensis subsp. sepedonicus,Rhodococcus opacus B4,Rhodococcus tukisamuensis,Rhodococcus yunnanensis,Rhodococcus kroppenstedtii,Rhodococcus kyotonensis,Aldersonia kunmingensis,Prescottella equi 103S,Rhodococcus koreensis,Bos taurus,Oryctolagus cuniculus,Sus scrofa,Equus caballus,Homo sapiens,Mus musculus,uncultured actinomycete,Bathymaster signatus,NA,NA)
• Biosynthetic pathway of leukotrienes (LTs), LT receptors, and mechanisms of action of antileukotriene drugs (reproduced with permission from reference ) (2010, NA)
• P38 MAPK signaling pathway (2010, NA)
• Core hypothalamic energy homeostatic circuit and the dopamine reward pathway (2010, NA)
• Classical Jak/STAT Signaling Pathway (2010, NA)
• Mechanism by which Ang II mediates vasoconstriction (2010, NA)
• Main pathway for the synthesis and degradation of 2-arachidonoylglycerol (2010, Bos taurus,Canis lupus familiaris,Sus scrofa,Ovis aries,Eutheria,Mus musculus,Rattus norvegicus,Candida dubliniensis,Cannabis sativa,Homo sapiens)
• Signaling pathways of sunitinib and sorafenib cardiotoxicity (2010, Homo sapiens)
• Effects of radiation, chemotherapy, and targeted agents on EGFR signaling (2010, NA)
• Targets for intervention in the TGFB1 pathway (partial list) [, , ] (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Hippospongia communis)
• PI3K/Akt/mTOR pathway signaling in tumor and vascular endothelial cells (2010, Homo sapiens)
• EGFR signaling pathway (2010, Homo sapiens)
• Signaling pathways and effects of EGFR (2010, NA)
• Bridged pairs and shared edges between 2ROs in the apoptosis pathway (2010, Gallus gallus,Danio rerio,teleost fish,Oryzias latipes,Xenopus tropicalis,Takifugu rubripes,Tetrapoda,Tetraodon nigroviridis,Amniota,Gasterosteus aculeatus,Vertebrata,Percomorphaceae,Bos taurus,Drosophila melanogaster,Canis lupus familiaris,Eutheria,Ciona intestinalis,Branchiostoma lanceolatum,Branchiostoma floridae,Bilateria,Ornithorhynchus anatinus,Monodelphis domestica,Ciona savignyi,Theria,Homo sapiens,Saccharomyces cerevisiae,Arabidopsis thaliana,Diaporthe sclerotioides,Macaca mulatta,Schizosaccharomyces pombe,Pan troglodytes,Gorilla gorilla,Mus musculus,Rattus norvegicus,Mouse mammary tumor virus)
• Mechanism of adiponectin stimulation of peroxisome proliferator‐activated receptor‐G coactivator 1A (PGC‐1A)‐dependent signalling (2010, Mus musculus,Homo sapiens)
• Hyperglycemia alters the expression of multiple genes of the transforming growth factor‐B (TGF‐B) pathway through the polyol pathway in retinal vessels (2010, NA)
• SPION-induced toxicity at cellular level (2010, Mus musculus,Rattus norvegicus,Homo sapiens,Calloplesiops altivelis)
• Eukaryotic Phospholipid Synthesis and Editing.G3P produced by GPDH is converted to PA by sequential acylation reactions regulated by GPAT and LPAAT (2010, NA)
• Proline Metabolism and Its Implications for Plant-Environment Interaction (2010, NA)
• Immune pathogenesis of gastric mucosa damage in H (2010, Helicobacter pylori)
• Signal pathways of IL-17 (2010, NA)
• Network analysis of expression profiles of 10 μmol/L AA in HK-2 cells (2010, NA)
• PDGF/PDGFR which leads to proliferation and anti-apoptosis in megakaryocytes (2010, NA)
• CHD1L in Nur77-mediated pathway during hepatocarcinogenesis (2010, Homo sapiens)
• AMPK-p53-mTOR pathway in metabolic adaptation (2010, NA)
• PI3K/Akt pathway involved in tumorigenesis (2010, NA)
• Schematic presentation of the rationale of targeting PARPs for cancer therapy (2010, NA)
• Altered cellular pathways and processes in tumours (2010, NA)
• Simplified view of the glucose sensing mechanisms in S (2010, Homo sapiens,Saccharomyces cerevisiae)
• Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells (2010, NA)
• Scheme of PMT-activated heterotrimeric G proteins and subsequent signaling pathways (2010, Pasteurella multocida,Homo sapiens)
• cDNA Microarray Gene Expression Profiling of Hedgehog Signaling Pathway Inhibition in Human Colon Cancer Cells (2010, NA)
• Molecular and genetic events in mammalian sex determination and differentiation (2010, Homo sapiens,Mus musculus,Caenorhabditis elegans,Non-A non-B hepatitis virus)
• PRRs involved in detecting flaviviruses (2010, NA)
• Signaling pathways involved in JSRV Env-induced cell transformation (2010, Human immunodeficiency virus 1,Human immunodeficiency virus,Mouse mammary tumor virus,Human betaherpesvirus 5,Adeno-associated virus,Human T-cell leukemia virus type I,Moloney murine leukemia virus,Rous sarcoma virus,Human endogenous retroviruses,Avian leukosis virus,Spleen focus-forming virus,Avian retrovirus,Human endogenous retrovirus K,Mason-Pfizer monkey virus,AKT8 retrovirus,Jaagsiekte sheep retrovirus,Avian sarcoma virus 17,Friend spleen focus-forming virus,Reticuloendotheliosis virus group,Avian sarcoma virus 16,Entebbe bat virus,Rous-associated virus type 1,Rous-associated virus type 2,Exogenous Jaagsiekte sheep retrovirus,Endogenous sheep retrovirus,Ovine enzootic nasal tumor virus,Bos taurus,Canis lupus familiaris,Capra hircus,Ovis aries,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Lambdavirus lambda)
• TLR-dependent and independent IFN-I induction, signaling and action (2010, NA)
• Mitochondria and neuroplasticity (2010, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,prion)
• HMGB1 signaling events mediated by RAGE and TLR2/4 and therapeutic strategies for cerebral ischemia (2010, NA)
• Putative signaling pathways leading to translational activation and enhanced MCT2 protein synthesis after BDNF treatment in cultured cortical neurons (2010, NA)
• Observation of the differentially expressed genes on the human cell cycle (A) and transforming growth factor beta (TGFB) signaling pathways (B) modified from Kyoto Encyclopedia of Genes and Genomes (KEGG) (www.genome.jp/kegg/kegg1.html) (2010, Homo sapiens,Bos taurus)
• Interaction between insulin and interferon-alfa signaling pathway (2009, NA)
• Look Who’s Talking: FGFs and BMPs in the Proepicardium (2009, Gallus gallus,Danio rerio,Homo sapiens)
• Convergent stem cell regulatory networks control expression of key stem cell genes (2009, Homo sapiens)
• Partial representation of the metabolic pathway for biosynthesis of steroids (Kegg map 00100) (2009, Arabidopsis thaliana,Zea mays,Embryophyta,Hordeum vulgare,Malus domestica,Olea europaea,Magnoliopsida,Eucalyptus grandis,Olea europaea var. sylvestris,Olea europaea subsp. europaea,Homo sapiens)
• Trehalose synthesis pathway in C (2009, NA)
• Signalling pathway activation by C5a on neutrophils, monocytes/macrophages and endothelial cells, resulting in compromised innate immunity, resistance of neutrophils to apoptosis, a cytokine storm and disseminated intravascular coagulation (2009, NA)
• Working model of the C (2009, NA)
• Regulation of mTORC1 signaling by mTOR S1261 phosphorylation (2009, NA)
• G protein-dependent and G protein-independent signaling activities of M33 (2009, Mus musculus,Murid betaherpesvirus 1,NA,Homo sapiens)
• Study background (2009, NA)
• Ingenuity pathway analysis shows 17 genes from the 180 genes associated with the NF-E2-related factor-2 (NRF-2)-mediated oxidative stress response pathway (2009, NA)
• Induction of IFNB and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7 (2009, NA)
• Crosstalk between Raf-dependent, positively regulated signal cascades and a PP2A-dependent negative signaling pathway in cerebral ischemia and reperfusion (2009, NA)
• Enzymatic function of multiple origins regulates the progression of colorectal cancer and the development of metastases (2009, NA)
• Proposed model of the relationship between p70S6K2 and the HH pathway (2009, NA)
• Elementary flux patterns in a condensed model of the TCA cycle and adjacent reactions (2009, Escherichia coli)
• ENOS regulation of CaMKKB/AMPK pathway via H2O2 (2009, Mus musculus,Bos taurus,Homo sapiens)
• Rb:E2F pathway (2009, Danio rerio,Chrysemys picta bellii,Trachemys scripta,Lithobates sylvaticus,Trachemys scripta elegans,Crypturellus undulatus,Mus musculus,Drosophila melanogaster,Caenorhabditis elegans,Ictidomys tridecemlineatus,Artemia franciscana,Urocitellus undulatus,Homo sapiens,NA)
• Regulation of OC differentiation and OC-osteoblast coupling (2009, NA)
• Insulin resistance (2009, NA)
• ATM/ATR DNA damage response pathway and its downstream effectors leading to either G1/S or G2/M phase arrest (2009, Danio rerio,Chrysemys picta bellii,Trachemys scripta,Lithobates sylvaticus,Trachemys scripta elegans,Crypturellus undulatus,Mus musculus,Drosophila melanogaster,Caenorhabditis elegans,Ictidomys tridecemlineatus,Artemia franciscana,Urocitellus undulatus,Homo sapiens,NA)
• Local Network Topology in Human Protein Interaction Data Predicts Functional Association (2009, NA)
• Inflammation at a molecular level: a simplified scheme (2009, Homo sapiens)
• NKG2D signalling pathways (2009, NA)
• Notch1 signaling-enhanced apoptosis induction by TRAIL in HCC cells (2009, Homo sapiens)
• Jak/Stat canonical pathway in human diabetic nephropathy as assessed by Ingenuity Pathway Analysis software (2009, NA)
• TCR and CCR7-triggered signals (2009, NA)
• Hypothetical scheme of activation of the murine Hamp1 promoter (2009, NA)
• Signal transduction through activin receptors (2009, NA)
• Early- and late-phase platelet aggregation regulated through PAR1 (2009, NA)
• Pathways of extrinsic and intrinsic apoptosis, highlighting roles of Bcl-2 family members (2009, NA)
• T cell receptor signalling canonical pathway obtained by IPA obtained in comparison MM8_PM8 (2009, Mus musculus,Rattus norvegicus,Eimeria maxima,Eimeria acervulina,Homo sapiens,Gallus gallus,Diaporthe sclerotioides)
• Canonical pathway underlines genes involved in inflammatory cytokines signalisation from the primary/secondary response comparison (PM8-MM8) (2009, Diaporthe sclerotioides,Sequoia sempervirens,Eimeria maxima,Eimeria acervulina,Homo sapiens,Gallus gallus)
• Mechanistic model for particle-related proinflammatory response that is consistent with our in vivo and in vitro data for CDNPs (2009, NA)
• Signaling pathway inferred from a gene regulatory network (2009, Saccharomyces cerevisiae,Ligustrum vulgare,Homo sapiens)
• FMLF-induced signaling events leading to the activation of phagocyte NADPH oxidase (Nox2) (2009, NA)
• RCAN1 mediated regulation of cell proliferation and apoptosis: Schematic shows that GC-dependent GR activation and subsequent MAP kinase-dependent phosphorylation enables GR binding to GRE sequences on target genes (2009, NA)
• TLR-mediated innate immune signaling pathway (2009, Saccharomyces cerevisiae,Ligustrum vulgare,Homo sapiens)
• LMO4 is an essential intermediate of ErbB2-induced proliferation (2009, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Mouse mammary tumor virus,vectors)
• Erb-associated signaling pathways (2009, Saccharomyces cerevisiae,Ligustrum vulgare,Homo sapiens)
• S-phase signaling pathways inferred with different heuristics (2009, Saccharomyces cerevisiae,Ligustrum vulgare,Homo sapiens)
• Quantitative Proteomics Analysis of Macrophage Rafts Reveals Compartmentalized Activation of the Proteasome and of Proteasome-mediated ERK Activation in Response to Lipopolysaccharide (2009, NA)
• Diagram depicting proliferative and survival signaling pathways in cells (2009, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Gallus gallus,Nicotiana tabacum,prion,Human gammaherpesvirus 8,NA)
• Nrf2 and transcriptional regulation of Gamma-GCSh expression (2009, NA)
• VacA or an H (2009, NA)
• Illustration of the mating pathway, initiated by pheromone stimulations, and the filamentous growth pathway, activated by nutrient starvation (2009, Saccharomyces cerevisiae,Homo sapiens)
• Proposed TGF-Beta-induced MCP-1/CCR2 loop in podocytes (2009, NA)
• Working models for homosynaptic versus heterosynaptic gating of LTP in postsynaptic neurons (2009, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Phaseolus vulgaris,Capra hircus,Meleagris gallopavo,Homo sapiens)
• Phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways (2009, NA)
• Signal transduction mechanisms implicated in leptin action (2009, NA)
• TrmB is a global bifunctional regulator, which coordinates the expression of evolutionarily diverse metabolic enzyme genes (2009, Escherichia coli,Bacillus subtilis,Bacillus subtilis At2,Pyrococcus furiosus,Haloferax volcanii,Saccharolobus solfataricus,Halobacterium salinarum,Thermococcus kodakarensis,halophilic archaeon,Methanococcus maripaludis,Halobacterium salinarum NRC-1,Thermococcus litoralis,Halobacterium salinarum R1,Venustaconcha ellipsiformis,Terminalia elliptica)
• Signaling cascades of the RP regulation (2009, NA)
• DNA replication checkpoint pathways in different organisms (2009, NA)
• Estrogen and membrane ERAlpha-inhibiting ATR pathway signaling after DNA damage (2009, Mus musculus,Homo sapiens)
• TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4 (2009, NA)
• Interleukin-6 and Neural Stem Cells: More Than Gliogenesis (2009, Mus musculus,Homo sapiens)
• Signal transducer and activator of transcription (STAT) proteins are activated by receptor and nonreceptor tyrosine kinases through several mechanisms (2009, NA)
• Time-Resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine (2009, Bacillus subtilis)
• Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder (2009, Homo sapiens)
• Arachidonic acid-induced activation of RhoA/ROCK in MDA-MB-435 cells (2009, Homo sapiens)
• Signaling pathway mediating thrombin-induced NFKB activation in endothelial cells (2009, Homo sapiens,Mus musculus)
• The MAPK signaling module organized by arrestin (2009, Bos taurus,Chlorocebus aethiops,Homo sapiens)
• Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data (2009, NA)
• Proposed model for FAK-dependent mechanism for the effects of CD151 (2009, Rattus norvegicus,Sus scrofa,Adeno-associated virus,Homo sapiens)
• IGF system: receptors, ligands, and signaling pathways (2009, Human immunodeficiency virus 1,Mouse mammary tumor virus,Homo sapiens,Mus musculus,Bos taurus)
• Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin (2009, Bos taurus,Capra hircus,Cutibacterium acnes,Vitreoscilla filiformis,Homo sapiens,Mus musculus,Candida dubliniensis)
• Genome-Wide Association Study Identifies Novel and Functionally Related Susceptibility Loci for Kawasaki Disease (2009, Homo sapiens,Pan troglodytes,Coxsackievirus B3,Human endogenous retrovirus K,Mus musculus)
• Similarities between the Cry toxin mode of action in Lepidoptera and Coleoptera (2009, Bacillus thuringiensis,Tenebrio molitor)
• Pathway involved in dehydration-dependent functional and regulatory networks in rice nucleus (2009, NA)
• MetaCore analysis of altered signaling pathways in OSCC samples (2009, NA)
• De novo purine synthesis pathway (2009, Danio rerio,Homo sapiens)
• Function and regulation of phospholipid signalling in plants (2009, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Glycine max,Solanum lycopersicum,Embryophyta,Cucumis sativus,Medicago truncatula,eudicotyledons,Ricinus communis,Avena sativa,Fulvia fulva,Lilium formosanum,Homo sapiens)
• Direct targets of WT1 identified in the Wnt signaling pathway (2009, NA)
• Schematic diagram illustrating four possible pathways for NAD biosynthesis (2009, NA)
• PROK1 induction of RCAN1-4 and IL-8 (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Respiratory syncytial virus,unidentified shuttle vector)
• Metabolic implication of leaf mitochondria during water stress (2009, NA)
• Possible signal transduction pathways of photosynthetic redox signals (2009, NA)
• Proposed mechanism for MAP4K3 cell death signaling (2009, NA)
• KEGG pathway: cell cycle (2009, Homo sapiens)
• NFKB signaling and MDR gene expression (2009, NA)
• PKC signaling hypothesis to explain stress-induced prefrontal cortical pyramidal cell structural modulation and PFC-dependent cognitive impairments (2009, NA)
• The current working model (2009, NA)
• Peptidoglycan Induces Cyclooxygenase-2 Expression in Macrophages by Activating the Neutral Sphingomyelinase-Ceramide Pathway (2009, NA)
• Proposed model for As2O3-dependent activation of the mTOR pathway in a negative feedback regulatory manner in malignant cells (2009, Homo sapiens)
• Bioelectric mechanisms in regeneration: unique aspects and future perspectives (2009, Gallus gallus,Danio rerio,Xenopus laevis,Ambystoma mexicanum,Lithobates pipiens,Gehyra xenopus,Drosophila melanogaster,Ciona intestinalis,Schmidtea mediterranea,Girardia tigrina,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Cavia porcellus,Acetabularia acetabulum,Bos taurus,Canis lupus familiaris,Homo sapiens)
• Signaling pathway for Ang II-stimulated VSMC migration (2009, Rattus norvegicus,Homo sapiens)
• Upon binding of insulin, the IR undergoes autophosphorylation which enables the receptor to have a kinase activity and phosphorylates various cytoplasmic substrates, such as IRSs (2009, NA)
• Darpp-32 and Its Truncated Variant t-Darpp Have Antagonistic Effects on Breast Cancer Cell Growth and Herceptin Resistance (2009, NA)
• Genes regulated by SHP in PPAR signaling pathway (2009, NA)
• Morphoproteomic Evidence of Constitutively Activated and Overexpressed mTOR Pathway in Cervical Squamous Carcinoma and High Grade Squamous Intraepithelial Lesions (2009, NA)
• Catabolic pathways encoded by the T (2009, NA)
• Cascade between VEGFA, a direct target of BP1, and its downstream target genes in cell proliferation (2009, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Notch, Wnt, and SHH signaling pathways (2009, NA)
• Scheme indicating expression of Tcf4 proteins and effects of Wnt–Beta-catenin signaling to inhibit the transition from premyelinating to mature oligodendrocyte (2009, NA)
• Immune activation induced by Beta-glucans (2009, NA)
• Cluster 2 genes significantly overlapped with those in the eicosanoid signaling pathway (P = 4.6E-05) (2009, Mus musculus,Homo sapiens)
• Insulin signaling pathway in adipose cells (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Insulin signal pathway and insulin insensitive (2009, NA)
• Interaction networks of As sensitivity in yeast (2009, Homo sapiens,Saccharomyces cerevisiae)
• Stress results in elevated catecholamine release in the prefrontal cortex (2009, Rattus norvegicus,Homo sapiens)
• Posttranscriptional regulation of Gamma-GCSh mRNA stability by the MAP kinase pathway under oxidative-stress conditions (2009, NA)
• An Occludin-Focal Adhesion Kinase Protein Complex at the Blood-Testis Barrier: A Study Using the Cadmium Model (2009, NA)
• Molecular Mechanisms of HIF-1A Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells (2009, NA)
• Metabolic reconstruction of Db (2009, Escherichia coli,Staphylococcus aureus,Escherichia coli K-12,Pseudomonas putida,Haemophilus influenzae,Bacteroides fragilis,Campylobacter jejuni,Synechocystis sp. PCC 6803,Fusobacterium nucleatum,Borreliella burgdorferi,Chlamydia trachomatis,Clostridium acetobutylicum,Mycobacterium tuberculosis H37Rv,Sinorhizobium meliloti,Zymomonas mobilis,Xanthomonas campestris,Pseudomonas putida KT2440,Bacillus subtilis subsp. subtilis str. 168,Caulobacter vibrioides,Thermotoga maritima,Methanocaldococcus jannaschii,Corynebacterium glutamicum ATCC 13032,Bradyrhizobium japonicum,Deinococcus radiodurans,Aquifex aeolicus,Cupriavidus necator H16,Archaeoglobus fulgidus,Agrobacterium fabrum str. C58,Acinetobacter baylyi ADP1,Clostridium kluyveri,Moorella thermoacetica,Leptospira interrogans,Desulfovibrio vulgaris,Mesorhizobium loti,Methanothermobacter thermautotrophicus,Nostoc sp.,Thermoplasma acidophilum,Geobacter sulfurreducens,Clostridium tetani,Methanosarcina mazei,Prochlorococcus marinus,Nitrosomonas europaea,Desulfovibrio vulgaris str. Hildenborough,Desulfovibrio desulfuricans,Methanopyrus kandleri,Desulfitobacterium hafniense,Methanococcus voltae,Megalodesulfovibrio gigas,Chlorobaculum tepidum TLS,Cupriavidus pinatubonensis JMP134,Methanothermobacter marburgensis,Dehalococcoides mccartyi 195,Bdellovibrio bacteriovorus,Syntrophotalea carbinolica,Methanosphaera stadtmanae,Desulforapulum autotrophicum,Rhodopseudomonas palustris CGA009,Rhodopirellula baltica,Aliivibrio fischeri ES114,Helicobacter pylori J99,Oceanobacillus iheyensis,Archaeoglobus fulgidus DSM 4304,Rhizobium etli CFN 42,Methanothermobacter thermautotrophicus str. Delta H,Oleidesulfovibrio alaskensis G20,Sulfolobus acidocaldarius DSM 639,Hyperthermus butylicus,Archaeoglobus profundus,Desulfitobacterium hafniense Y51,Desulforapulum autotrophicum HRM2,Burkholderia mallei ATCC 23344,Geobacter sulfurreducens PCA,Desulfovibrio desulfuricans ATCC 27774,Desulfofarcimen acetoxidans,Geobacter metallireducens GS-15,Haloarcula marismortui ATCC 43049,Anaeromyxobacter dehalogenans 2CP-C,Desulfotalea psychrophila,Desulfobacter postgatei,Thiobacillus denitrificans ATCC 25259,Syntrophus aciditrophicus SB,Desulfosudis oleivorans Hxd3,Desulfotalea psychrophila LSv54,Clostridium tetani E88,Moorella thermoacetica ATCC 39073,Cutibacterium acnes KPA171202,Salinibacter ruber DSM 13855,Nitrobacter winogradskyi Nb-255,Aromatoleum aromaticum EbN1,Methanothermobacter marburgensis str. Marburg,Oryza sativa,Eucalyptus intertexta,Homo sapiens,stable RNAs)
• Distributions of the orthologous gene groups containing duplicate genes that arose through 3R-WGD (shown as gray boxes) in the network diagrams (2009, Gallus gallus,Danio rerio,Xenopus laevis,teleost fish,Oryzias latipes,Dipnomorpha,Xenopus tropicalis,Takifugu rubripes,Tetrapoda,Tetraodon nigroviridis,Gasterosteus aculeatus,Gnathostomata,Teleostei,Latimeria chalumnae,Callorhinchus callorynchus,Latimeria menadoensis,Drosophila melanogaster,Paracentrotus lividus,Ciona intestinalis,Branchiostoma lanceolatum,Paramecium tetraurelia,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Arabidopsis thaliana,Canis lupus familiaris,Pan troglodytes,Mus musculus)
• Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence (2009, NA)
• Functional and structural organization of migratory mesenchymal cells (2009, NA)
• Schematic diagram showing pathways of EET-mediated improved left ventricular function (2009, NA)
• Known components of the IFN signalling pathway and explanation of observed results (2009, NA)
• Phosphatase and tensin homolog (PTEN) is a tumour suppressor gene involved in the regulation of the threonine kinase protein kinase B (PKB/akt) pathway, by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) (2009, NA)
• Schematic model of pneumococci-induced signaling molecules (2009, NA)
• Alternative kinetic model incorporating unknown transcription factor (TFx) activation by Eda/Edar signaling (2009, NA)
• Diabetes alters the expression of multiple genes of the TGFB pathway (left side of the panel) and BMPs pathway (right side) in rat retinal vessels (2009, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis (2009, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Xenopus laevis)
• Transcriptional regulation of cell cycle arrest gene p21 by ZBTB5 (2009, NA)
• FXR-independent and bile acid-activated cell signaling pathways in regulation of CYP7A1 transcription (2009, NA)
• FXR regulation of enterohepatic circulation of bile acid (2009, NA)
• Modular Organization of Protein Interactions in Escherichia coli (2009, Escherichia coli)
• The ER–mitochondria apoptotic signalling pathway operating in cells devoid of mitochondrial BAK and BAX, and of ER-located BAX (2009, NA)
• PDE4B signaling interactions highlight novel opportunities for combined therapeutic approaches in DLBCL (2009, Mus musculus,Homo sapiens)
• The NKG2D signaling pathway in CTLs (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Bikinia letestui,Leucanthemum maximum,Homo sapiens,vectors,Corynebacterium phage gamma)
• Hedgehog Signaling Pathway: Where Did It Come From? (2009, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Simplified schematic representation of the interaction between the mTORC1 and ERK1/2 signaling pathways following muscle contraction and/or insulin stimulation (2009, NA)
• Simplified schematic representation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway driven by muscle contraction, insulin, essential amino acids (leucine), and/or energy (2009, NA)
• Simplified schematic illustrates how the ERB mediates activation of PI3K/Akt and apoptotic pathway and thus protects the female myocardium in response to I/R (2009, NA)
• The VACV- and CPXV-stimulated PI3K/Akt pathway of biological relevance in spontaneously immortalized A31 and MEF cells (2009, NA)
• Revised PIM and LAM biosynthetic pathway in M (2009, NA)
• Gonad function and sexual differentiation (2009, Homo sapiens)
• Roles of BMP signaling pathways during SNS development (2009, NA)
• BMP7 signaling in the NZ (2009, NA)
• Cliques or near cliques from the cancer pathway related network Gp (2009, Homo sapiens,Saccharomyces cerevisiae)
• Carbazole-catabolic pathway in Pseudomonas strains harboring pCAR1.1 or pCAR1.2 (2009, NA)
• Gene Expression Profiling in Cells with Enhanced Gamma-Secretase Activity (2009, NA)
• A model for the role of the Wnt-Sox2 pathway in the transition from a progenitor to a differentiated cell (2009, Xenopus laevis,Homo sapiens)
• Salivary and Intestinal Complement System Inhibitors in the Midgut Protection of Triatomines and Mosquitoes (2009, Trypanosoma cruzi,Aedes aegypti,Ixodes scapularis,Rhodnius prolixus,Leishmania chagasi,Lutzomyia longipalpis,Ctenocephalides felis,Triatoma infestans,Triatoma brasiliensis,Panstrongylus megistus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Cerdocyon thous,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Diaporthe sclerotioides,Borreliella burgdorferi)
• Regulatory pathways in hepcidin expression (2009, NA)
• Schematic illustration of the proposed stimulation of HAS isoform regulation by prostaglandins in cancer cells (2009, NA)
• NFKB signaling pathway was the most significant canonical pathway in HBMEC up-regulation (2009, NA)
• Mechanism of the time-dependent activation of Phox2a by cAMP signaling (2009, NA)
• Synthesis, storage, and release of BDNF (2009, NA)
• Gene transcripts associated with sensitivity to gefitinib and EGFR and/or head and neck cancer, identified from the genome‐wide statistical analysis, followed by pathway analysis (2009, NA)
• Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection (2009, NA)
• TNF A inhibits erythropoiesis by direct and indirect effects (2009, NA)
• Part of Pancreatic cancer pathway adapted from KEGG showing the gene-gene interactions (2009, Homo sapiens,Nicotiana tabacum)
• Regulation of chromatin structure by drugs of abuse (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Extracellular Superoxide Dismutase Is a Growth Regulatory Mediator of Tissue Injury Recovery (2009, Rattus norvegicus,Oryctolagus cuniculus,Homo sapiens)
• HSV-mediated Transfer of Artemin Overcomes Myelin Inhibition to Improve Outcome After Spinal Cord Injury (2009, Rattus norvegicus,Homo sapiens)
• Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands (2009, Mus musculus,Homo sapiens)
• Proposed mechanism of TNFAlpha-induced mitochondrial dysfunction and activation of apoptotic signaling pathways in the intestinal epithelial cells during NEC (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Mitochondrial DNA Variants in the Pathogenesis of Type 2 Diabetes - Relevance of Asian Population Studies (2009, NA)
• Disruption of metabolic pathways involved in fat pad mass trait in mouse models of the candidate genes (2009, Saccharomyces cerevisiae,Zea mays,Diaporthe sclerotioides,Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathways of autophagy control in mammalian cells (2009, NA)
• Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells (2009, Mus musculus,Rattus norvegicus,Human alphaherpesvirus 1,Semliki Forest virus,Homo sapiens,Lareunionomyces loeiensis)
• Pigmentation Pathway Evolution after Whole-Genome Duplication in Fish (2009, NA)
• PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL) (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Canis lupus familiaris)
• Redoxosomal signaling for IL-1B and TNFA pathways (2009, NA)
• Molecular Aspects of Moraxella catarrhalis Pathogenesis (2009, Moraxella catarrhalis,Homo sapiens)
• Cystic fibrosis transmembrane conductance regulator in reproductive health and disease (2009, NA)
• Summary of NSP1 inhibition of the innate immune response pathway (2009, Rotavirus A,Homo sapiens)
• HCV induces the over-expression of PP2Ac via an ER stress response pathway (2009, Homo sapiens,Pan troglodytes,Mus musculus,Saccharomyces cerevisiae,Influenza B virus,NA,NA)
• Innate immune evasion mechanisms of HSV (2009, Human alphaherpesvirus 1,Human alphaherpesvirus 2,Homo sapiens,Mus musculus,NA)
• Activation of antiviral and proinflammatory responses during HSV infections (2009, Human alphaherpesvirus 1,Human alphaherpesvirus 2,Homo sapiens,Mus musculus,NA)
• Ingenuity pathway analysis and expression profiles of genes involved in apoptosis that were uniquely up regulated in ER+ cells in response to EPA (2009, NA)
• Insulin receptor cascade was uniquely up regulated in ER− cells when treated with AA (2009, NA)
• Genes involved in cell-cell signaling significantly associated with ERbreast cancer cells in response to AA (2009, NA)
• Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer (2009, NA)
• IFNG signaling through the JAK/STAT1 pathway (2009, NA)
• Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart (2009, NA)
• Sub-network associated with the Wnt signaling pathway (2009, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Candida dubliniensis,Homo sapiens)
• Estrogen’s Place in the Family of Synaptic Modulators (2009, NA)
• Depiction of the “Reelin signalling in neurons” pathway generated by Ingenuity (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• An Ingenuity pathway analysis containing about half of the genes in subfactor 8 of Myc factor 6 (2009, Homo sapiens)
• Disulfiram inhibition of the norepinephrine (NE) biosynthetic pathway (2009, Homo sapiens)
• Altered signaling pathways and mouse models of thyroid cancer (2009, NA)
• Putative signaling pathway involved in radiation-induced salivary gland dysfunction (2009, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Adeno-associated virus,adeno-associated virus 2,Sus scrofa)
• Nuclear factorKB (NFKB) can be activated by a multitude of different stimuli, like TNFA, LPS and CD40L (2009, Human immunodeficiency virus,Adeno-associated virus,Moloney murine leukemia virus,adeno-associated virus 2,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Imd pathway in adult Drosophila melanogaster (2009, NA)
• Selection of expression patterns and activities of members of the cadherin superfamily in cancer (2009, NA)
• TNF-induced NFKB pathway (2009, NA)
• Jak/STAT signaling pathway (2009, NA)
• The effects of HCV on steatosis development (2009, Hepatitis B virus,Hepatitis C virus genotype 3,Hepatitis C virus subtype 3a,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,NA)
• Akt signaling pathway (2009, NA)
• Some of the effects brought about by HCV on insulin signaling in hepatocytes (2009, Hepatitis B virus,Hepatitis C virus genotype 3,Hepatitis C virus subtype 3a,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,NA)
• Ca2+ homeostasis in the neuron (2009, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Callithrix jacchus,Delphinus delphis,Xenopus laevis)
• Albumin alters TGFB pathway gene expression (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Proposed model for the effect of HPTE in the granulosa cell (2009, Rattus norvegicus,Homo sapiens)
• Summary of environmentally responsive signaling pathways and Streptococcus interactive mechanisms in C (2009, Candida albicans,Streptococcus gordonii,Homo sapiens)
• Display of genes with high expression in IVF embryos (2009, Escherichia coli,Bacillus subtilis,Actinobacillus minor,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Ret gene structure and signaling (2009, Homo sapiens,Mus musculus)
• HIV-1 TAT T cell receptor signaling pathway (2009, Human immunodeficiency virus 1,HIV-1 group M,Homo sapiens,Helicobacter pylori,Venustaconcha ellipsiformis)
• Summary of the pathways transduced by the primary cilium (2009, Oryctolagus cuniculus,Canis lupus familiaris,Paraechinus aethiopicus,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Chlamydomonas reinhardtii,Paracentrotus lividus,Zoysia japonica,Homo sapiens,Mus musculus)
• In young mutant mice with low p25 expression, GSK3B is inhibited by phosphorylation at Ser 9 (2009, NA)
• Genomic Strategy to Elucidate Modules of Oncogenic Pathway Signaling Networks (2009, NA)
• Human presenilin 1 and 2 (PSEN1 and PSEN2) subnetworks (2009, Ciona intestinalis)
• Proposed mechanism by which PSD-95 interferes with D1–NMDA receptor interaction and uncouples modulation of D1 function by the NMDA receptor (2009, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Armoracia rusticana)
• Minimum spanning tree of the network associated with cancer pathway genes (2009, Homo sapiens,Saccharomyces cerevisiae)
• Schematic view of PPARG activation in VSMCs (2009, NA)
• IL-1Beta-induced upregulation of RGS4 expression in colonic SMCs via canonical IKK2/IKBA/NFKB signaling is differentially modulated by the MAPK and PI3K/Akt/GSK3B pathways (2009, Oryctolagus cuniculus,Homo sapiens)
• CKI members in canonical Wnt signaling (2009, NA)
• Glycerol phosphate pathway for de novo triacylglycerol (TAG) and glycerophospholipid synthesis (2009, Homo sapiens,Mus musculus)
• Diagram connecting the insulin pathway and fatty acid (FA) biosynthesis (2009, Hepatitis B virus,Hepatitis C virus genotype 3,Hepatitis C virus subtype 3a,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,NA)
• Hormone and nutrient signaling pathways modulating leptin translation (2009, NA)
• Putative functions of caspase-2 (2009, NA)
• Toll-like receptor (TLR) activation (2009, NA)
• Schematic overview of the human tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) apoptosis pathway (2009, Mus musculus,Homo sapiens)
• F igure 8.— (2009, NA)
• Hh signalling—a simplified model (2009, Homo sapiens,Mus musculus)
• Signaling control of mesenchymal and amoeboid cell phenotypes (2009, NA)
• Arachidonic acid metabolism pathway (2009, Homo sapiens,Saccharomyces cerevisiae,Venustaconcha ellipsiformis,Escherichia phage T7)
• Cetuximab in the treatment of colorectal cancer (2009, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• SOS response gene network in P (2009, NA)
• Targets for immunosuppressive drugs (2009, NA)
• Fumarate/nitrate response regulator network in P (2009, NA)
• Maintenance of the G1/S DNA damage checkpoint in the presence and absence of Cdk2 (2009, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Molecular targets of natural chemopreventive agents (2009, NA)
• Metabolic reconstruction of H (2009, NA)
• Schematic diagram showing the Ras signalling pathway and its linkage to the GTPase cellular motility axis (Reproduced with permission from) (2009, NA)
• Grade-dependent Proteomics Characterization of Kidney Cancer (2009, Homo sapiens)
• The Cdc42-dependent regulation of neural differentiation in P19 cells (2009, NA)
• TNF-induced NFKB and apoptosis pathways (2009, Homo sapiens,Saccharomyces cerevisiae,Venustaconcha ellipsiformis,Escherichia phage T7)
• Proteomics and Pathway Analysis Identifies JNK Signaling as Critical for High Linear Energy Transfer Radiation-induced Apoptosis in Non-small Lung Cancer Cells (2009, NA)
• Prostaglandin F2Alpha-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium–calcineurin–NFAT pathway (2009, Oryctolagus cuniculus,Capra hircus,Helicobacter pylori,Adenoviridae,Respiratory syncytial virus,Chromobacterium sp.,Homo sapiens,Mus musculus)
• Pathway deregulation in ovarian cancer (2009, Homo sapiens,Mus musculus,Drosophila melanogaster,Mouse mammary tumor virus)
• Crosstalk of Notch with p53 and p63 in cancer growth control (2009, NA)
• Crosstalk of Notch with p53 and p63 in cancer growth control (2009, NA)
• An integrated pathway model involving FOXA1 in breast cancer (2009, Homo sapiens,Mus musculus,Drosophila melanogaster,Arabidopsis thaliana)
• Schematic model of the angiopoietin-Tie2 ligand-receptor system (2009, NA)
• Cell cycle pathway gene expression (2009, Homo sapiens,Mus musculus,Drosophila melanogaster,Mouse mammary tumor virus)
• Proposed mechanisms of toxicity in SOD1-mediated ALS (2009, NA)
• Reversal of EMT induced by TGFB1 (2009, Bos taurus,Canis lupus familiaris,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Purine biosynthetic pathway, showing protein abundance changes for the P (2009, Porphyromonas gingivalis,Homo sapiens)
• Different kinase signaling pathways link distinct stress signals to catalyze p53 phosphorylation at Ser20 in the TAD1 transactivation domain (2009, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Raphanus sativus,Human betaherpesvirus 6,Human betaherpesvirus 6B,Homo sapiens,Dipturus trachyderma,Ciona intestinalis,Lactobacillus phage PL-1)
• Cell cycle in somatic cells vs (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• TOR intracellular signaling pathway (2009, NA)
• Pathogenesis of holoprosencephaly (2009, NA)
• Networks used to generate simulated data (2009, NA)
• Reconstruct part of KEGG pathway by our method (2009, Escherichia coli IS1,Escherichia coli IS5,Escherichia coli SCD1,Homo sapiens,Saccharomyces cerevisiae)
• Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen (2009, NA)
• Growth signal pathway (2009, NA)
• Apoptosis pathway (2009, NA)
• Antigrowth signaling pathway and cluster around SMAD proteins (2009, NA)
• Matriptase-2 in the hepcidin regulatory pathway (2009, Homo sapiens,Mus musculus)
• Model of stress -signalling to PRC1: In the nucleus of resting cells, a sub-population of MK2 (and MK3) is associated to PRC1 via specific interaction to Edr2 (and/or Edr1) (2009, Mus musculus,Homo sapiens)
• Network analysis of the top 250 predictor genes (2009, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Schematic diagram depicting the pathway via which GC-A signaling inhibits cardiac hypertrophy (2009, NA)
• Proposed scheme showing potential alternative pathways and redundancy in the biosynthesis pathway of PIMs, LM, and ManLAM (2009, Mycobacterium tuberculosis,Homo sapiens)
• Azithromycin Treatment Alters Gene Expression in Inflammatory, Lipid Metabolism, and Cell Cycle Pathways in Well-Differentiated Human Airway Epithelia (2009, NA)
• Integration of BMP, FGF and Wnt signalling at the level of Smad1 during neural induction (2009, Gallus gallus,Danio rerio,Xenopus laevis,Petrocephalus catostoma,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Schematic model of molecular mechanisms underlying regulation of gene transcription and protein translation during mGluR-LTD in postsynaptic neurons of hippocampal CA3-CA1 synapses (2009, NA)
• Molecular mechanisms that regulate ionotropic glutamate receptor distribution during hippocampal mGluR-LTD induction and expression (2009, NA)
• Impact of a mixed microbial challenge on cell cycle control in HIGK (2009, NA)
• Ingenuity pathway analysis of proteins displaying alterations in expression patterns following infliximab treatment in patients deemed to be non-responders (2009, NA)
• Phosphoinositide 3 kinase (pi3k)/protein kinase B (Akt) signalling pathway (2009, Homo sapiens,Mus musculus)
• Map of BCR-pathway (2009, Helicobacter pylori,Borreliella burgdorferi,Chlamydia trachomatis,Mycoplasmoides genitalium,Ureaplasma urealyticum,Bos taurus,Mustela erminea,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Human alphaherpesvirus 3)
• Signaling pathway leading to Egr-1 biosynthesis in thrombin or carbachol-stimulated 39M1-81 cells (2009, NA)
• Identification of candidate molecular network for miRNAs most highly changed in response to DEP (2009, NA)
• Subnetworks of select putative DEP-regulated gene transcripts show an enrichment of inflammatory response (2009, NA)
• Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium (2009, NA)
• Scheme of the model for the mammalian cell cycle (2009, NA)
• Connective tissue associated signalling network common to various cardiac hypertrophy animal models and human cardiac disease (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schemata of mechanisms underlying the prevention of diabetes development by inhibition of the renin–angiotensin system (RAS) (2009, NA)
• Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway (2009, NA)
• Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis (2009, NA)
• Summary of the Effects of Nitrate, LBD37, 38, or 39, and PAP1 Overexpression on the Anthocyanin Biosynthesis Pathway.Anthocyanin-specific pathway steps in flavonoid metabolism are shown in a yellow background (2009, NA)
• Gene Expression Profiling of Lymphoblasts from Autistic and Nonaffected Sib Pairs: Altered Pathways in Neuronal Development and Steroid Biosynthesis (2009, NA)
• Live from the Liver: Hepatocyte IL-7 (2009, NA)
• Kinetic scheme of the integrated signaling network (2009, NA)
• TSC1/2 integrates multiple signals to control cell growth and proliferation (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Putative signaling pathways involved in the anti-proliferative/prosurvival actions of Lot1 in cerebellar granule cell precursors (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• NO/cGMP and calcium signaling in osteoblast mechanotransduction (2009, NA)
• Class IA PI3K signalling pathway (2009, NA)
• Cross-Talk between Signaling Pathways Can Generate Robust Oscillations in Calcium and cAMP (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Summary of Trif-biased signaling and selective p38 activation by sMLA (2009, Mus musculus,Homo sapiens)
• Interleukin (IL)-13/transforming growth factor (TGF)B signalling pathways (2009, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Hepatitis B virus,Homo sapiens,Schistosoma mansoni,NA)
• IKKA and IKKB Regulation of DNA Damage-Induced Cleavage of Huntingtin (2009, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Diagrammatic representation of the signalling pathways activated in the unfolded protein response following ER stress (2009, NA)
• Dopamine D1–D2 receptor heteromer signaling pathway (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Androgen-receptor signalling in normal prostate and PCa (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Lipid emulsions – Guidelines on Parenteral Nutrition, Chapter 6 (2009, Escherichia coli,Pseudomonas aeruginosa,Escherichia coli IS1,Escherichia coli IS9,Glycine max,Candida albicans,Olea europaea,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Anti-inflammatory effects of EPAC in VECs (2009, NA)
• Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryza sativa,Mustela lutreola)
• Changes in the pRb and p53 pathway promoting cell cycle passage in high-grade central chondrosarcoma, as found in the present and previous studies (2009, Homo sapiens,Mus musculus,Bos taurus,clinical samples)
• Proposed schematic charts showing various mechanisms by which CSp and SeSp extracts inhibit LNCaP cell proliferation (2009, Saccharomyces cerevisiae,Oryza sativa,Malus domestica,herbal medicine,Brassica oleracea,Brassica oleracea var. italica,Phaleria macrocarpa,Mus musculus,Rattus norvegicus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Bos taurus,mixed sample)
• Oxidative stress induced lung cancer and COPD (2009, NA)
• Stretch Activates Human Myometrium via ERK, Caldesmon and Focal Adhesion Signaling (2009, NA)
• Activation of Wnt/Beta-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells (2009, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens)
• Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells (2009, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Malus domestica)
• Phosphatidylcholine metabolism (2009, NA)
• Schematic depiction of the signal transduction events occurring in microglia following P2X7 receptor activation (2009, NA)
• SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response (2009, NA)
• Differential sorting of nephrin along endocytic pathways is shown (2009, NA)
• Proposed signal transduction pathways in fetal and adult cerebral arteries for PKC-induced contraction (2009, Ovis aries,Homo sapiens)
• IFNG signaling pathway in retinal pigment epithelium (2009, NA)
• Leptin signaling and leptin resistance (2009, NA)
• In MSTN-null mice, regulators of the PI3K pathway and cell survival/apoptosis likely contribute to muscle hypertrophy (2009, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Caenorhabditis elegans,Gallus gallus,Armoracia rusticana)
• Putative host signaling pathway induced by Y (2009, NA)
• The fungal cell wall and downstream cellular responses following engagement of Dectin-1 and TLRs on antigen presenting cells (APC) (2009, NA)
• Signal pathways in systemic regulation of hepcidin (2009, NA)
• LMP1 in promoting survival in PTLD (2009, NA)
• Decomposition of Gene Expression State Space Trajectories (2009, NA)
• Diagram representing lymphocyte stimulation and inhibition pathways (2009, NA)
• Possible mechanisms of UbcH7 regulation of Chk1 levels sand S phase (2009, NA)
• Aberrant Myc expression causes mammary cancer (2009, NA)
• Novel antifibrotic therapies in systemic sclerosis (SSc) (2009, NA)
• Comparative Analysis of Gene Expression Patterns and Cell Phenotypes between Cervical and Peripheral Blood Mononuclear Cells (2009, NA)
• Schematic model showing the role of physiological synaptic vs (2009, NA)
• Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy (2009, NA)
• Summary of glutathione (l-Gamma-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C (2009, NA)
• TGFB: A New Role for an Old AktTOR (2009, NA)
• Proposed model for AMSH and UBPY function in the pathway of agonist-induced trafficking of PAR2 (2009, NA)
• Wnt signalling pathway downregulated in osteosarcoma (2009, NA)
• ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis (2009, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages (2009, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza A virus H3N2,Canis lupus familiaris,Sus scrofa,Mustela putorius furo,Homo sapiens,Mus musculus,Helicobacter pylori)
• Regulation of mTORC1 mTORC1 is a multiprotein complex composed of Raptor, mLST8, PRAS40, and FKBP38 and regulates protein synthesis and cell growth by phosphorylating S6K1 and 4EBP1 (2009, NA)
• Oxidative Stress and PD pathobiology (2009, NA)
• Working Model (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Caenorhabditis elegans,vectors,Moloney murine leukemia virus)
• Signaling pathway whereby tumor associated macrophages promote Wnt signaling in tumor cells (2009, Homo sapiens,Mus musculus,Bos taurus)
• TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cytokine and cytokine-receptor interaction pathway (2009, Mus musculus,Rattus norvegicus,unidentified influenza virus,Curcuma longa,Zingiber officinale,Human rhinovirus sp.,Homo sapiens,Bos taurus)
• TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the cell-adhesion pathway (2009, Mus musculus,Rattus norvegicus,unidentified influenza virus,Curcuma longa,Zingiber officinale,Human rhinovirus sp.,Homo sapiens,Bos taurus)
• TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the apoptosis pathway (2009, Mus musculus,Rattus norvegicus,unidentified influenza virus,Curcuma longa,Zingiber officinale,Human rhinovirus sp.,Homo sapiens,Bos taurus)
• TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway (2009, Mus musculus,Rattus norvegicus,unidentified influenza virus,Curcuma longa,Zingiber officinale,Human rhinovirus sp.,Homo sapiens,Bos taurus)
• Base excision repair (BER) pathway (2009, NA)
• F igure 3.— (2009, NA)
• Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice (2009, NA)
• Continued defect in IRF-3-deficient BMDCs (2009, NA)
• Schema of the HER family signaling pathways (2009, NA)
• Sialic Acid Utilisation and Synthesis in the Neonatal Rat Revisited (2009, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Diaporthe sclerotioides)
• Proposed pathways for promotion (A) and progression genes (B) influenced by TLR4 (2009, NA)
• Up-regulation of TGFB signaling in Timp3−/−-AB hearts (2009, NA)
• Mechanism of the inhibition by 8-Cl-ADO in B-lymphocytes (2009, NA)
• Comparison of growth factor receptor signalling: This figure shows a comparison of ERK signalling from the EGF and Insulin receptors (2009, NA)
• UFA synthesis in E (2009, NA)
• Cytoprotective APC pathway (2009, NA)
• Expression-Based Network Biology Identifies Alteration in Key Regulatory Pathways of Type 2 Diabetes and Associated Risk/Complications (2009, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Cytoskeletal Remodeling: FAK Signaling pathway is enriched for HeLa and TOV edge hits using PIPA but not node hits using HGA enrichment (2009, Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster)
• PAK Signaling in Oncogenesis (2009, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• Schematic model depicting the putative mechanisms involved in the hypoxic regulation of CD36 (2009, NA)
• Ingenuity Pathway Analysis® network depicting relationships among genes involved in immune and metabolic responses due to IMI with Streptococcus uberis (2009, Streptococcus uberis,Escherichia coli,Staphylococcus aureus,Serratia marcescens,Streptococcus agalactiae,Mus musculus,Rattus norvegicus,Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Bos taurus,Emberiza citrinella,NA)
• Cyclin-dependent kinase (CDK) 5 (A) and Insulin-like growth factor (IGF)-1 signaling pathways (B) among 2,102 differentially expressed genes due to intramammary infection with Streptococcus uberis (2009, Streptococcus uberis,Escherichia coli,Staphylococcus aureus,Serratia marcescens,Streptococcus agalactiae,Mus musculus,Rattus norvegicus,Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Bos taurus,Emberiza citrinella,NA)
• IL-10 and IL-6 signaling pathways among 2,102 DEG due to IMI with Streptococcus uberis (2009, Streptococcus uberis,Escherichia coli,Staphylococcus aureus,Serratia marcescens,Streptococcus agalactiae,Mus musculus,Rattus norvegicus,Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Bos taurus,Emberiza citrinella,NA)
• Insulin-like growth factor-1-phosphotidylinositol-3-kinase-protein kinase-B serine/threonine kinase-forkhead box-O pathway (2009, NA)
• p53-regulated pathway analysis using the Ingenuity Pathway Knowledge Base (IPKB) (2009, Mus musculus,Rattus norvegicus,Cricetulus griseus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Lareunionomyces loeiensis,prion,Simian endogenous retrovirus)
• Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis (2009, NA)
• Insulin–EGF signal integration (2009, NA)
• Promoting cell proliferation and repressing differentiation (2009, Homo sapiens)
• TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway (2009, NA)
• Redox control of the cell cycle and cardiovascular diseases (2009, NA)
• The mechanisms of bradykinin B2 receptor-mediated responses to agonists in HEK 293 cells (2009, Homo sapiens,Oryctolagus cuniculus)
• Insulin resistance and hyperinsulinaemia in the development and progression of cancer (2009, NA)
• Cpr2 activates the pheromone signalling pathway to regulate morphogenesis in C (2009, NA)
• Insulin resistance and hyperinsulinaemia in the development and progression of cancer (2009, NA)
• Discovery of PDK1 () enabled an outline of the insulin-stimulated signaling pathway that leads to the activation of glycogen synthase to be formulated for the first time (2009, NA)
• Resolution of immune activation defines nonpathogenic SIV infection (2009, Simian immunodeficiency virus)
• Halting the Migration♦ (2009, NA)
• Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Embryonic Stem Cell Differentiation (2009, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Schematic summary of LPS-triggered programmed cell death in human endothelial cells (2009, NA)
• Proposed model (2009, NA)
• Speculative model depicting mono-ubiquitination-dependent and independent functions of the FA-BRCA pathway in DNA replication-associated repair processes (2009, Homo sapiens,Chlorocebus aethiops)
• HGF-mediated inhibition of gluconeogenesis in primary hepatocytes (2009, NA)
• Schematic diagram for HO-1 modulation of signaling pathway and adiponectin, EET levels, and vascular function (2009, NA)
• An integrated model for the function of TopBP1 in the normal cell cycle and in cancer cells (2009, Homo sapiens,Mus musculus)
• A link between glucose and insulin signaling in Beta-cells (2009, NA)
• During normoxia, HIF-1A is rapidly degraded by the ubiquitin-proteasome pathway (2009, NA)
• Regulation of autophagy (2009, NA)
• Scheme depicting the major compartments of the endocytic pathway and selected endocytic proteins participating in the transmission of signaling to the nucleus, by affecting the transcription machinery and/or the chromatin‐remodeling factors (2009, NA)
• Internalization routes influence signaling output (2009, NA)
• Proposed model of the role of p47 in E (2009, NA)
• The extrinsic and intrinsic apoptotic pathway (2009, NA)
• Proposed signaling pathway for adenosine-mediated inhibition of collagen production (2009, NA)
• Identified proteins within the primary metabolism (2009, Aspergillus niger,Homo sapiens)
• Specificity of thyroid hormone signaling through plasma membrane integrins (2009, NA)
• Example of pathway segments corresponding to FALZ identified from breast cancer data (Figure drawn with Cytoscape) (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• AGS3 up-regulation and cAMP superactivation (2009, Rattus norvegicus,Homo sapiens)
• Pathways surrounding transaldolase (2009, NA)
• Activation of the mitochondrial pathway of apoptosis during cisplatin nephrotoxicity by p53-dependent and -independent mechanisms (2009, NA)
• Biosynthetic Pathway of Coenzyme Q10 (2009, NA)
• Methylobacterium Genome Sequences: A Reference Blueprint to Investigate Microbial Metabolism of C1 Compounds from Natural and Industrial Sources (2009, Helicobacter pylori,Cereibacter sphaeroides,Francisella tularensis,Methylorubrum extorquens,Methylorubrum extorquens AM1,Paracoccus denitrificans,Leptospira kmetyi,Mesorhizobium loti,Methylococcus capsulatus,Paraburkholderia xenovorans LB400,Ruegeria pomeroyi,Methylobacterium sp.,Methylibium petroleiphilum PM1,Methylobacillus flagellatus KT,Methylobacillus flagellatus,Methylobacterium nodulans,Plasmid P1,Methylorubrum extorquens PA1,Methylorubrum extorquens DM4,Methylorubrum rhodesianum,Granulibacter bethesdensis,Methyloversatilis universalis,Methylibium petroleiphilum,Albibacter helveticus,Methylacidiphilum infernorum,Nitrobacter hamburgensis X14,Diaporthe sclerotioides,Magnoliopsida,Medicago truncatula,Homo sapiens,uncultured beta proteobacterium,Sturnus vulgaris)
• Proposed cell signaling pathway of noradrenergic influence on CRF transcription (2009, NA)
• Illustration of some of the key enzymes involved in the metabolism of methotrexate (MTX) (2009, NA)
• Proposed IGF-1 signaling pathway in renal carcinogenesis induced by uninephrectomy (2009, Rattus norvegicus,Homo sapiens)
• Ingenuity pathway analysis (IPA) of microarray data generated several genetic networks (2009, NA)
• Transmigration causes differential expression of genes in the apoptosis pathway (2009, Homo sapiens)
• Apoptosis and the main anti-apoptotic molecules: Binding of death receptors (Fas, TNF-R, TRAIL-R) to their ligands (Fas-L, TNF, TRAIL) initiates the extrinsic apoptotic pathway (2009, NA)
• Proposed pathway from pressure overload to LV hypertrophy and fibrosis (2009, NA)
• Working hypothesis for how meiotic arrest is maintained and how LH causes meiotic resumption in follicle-enclosed mouse oocytes (2009, NA)
• SLK activation and recruitment at the leading edge (2009, NA)
• Proposed saxitoxin biosynthetic pathway (2009, NA)
• Enzymatic sources of ROS, their effects and pharmacological modulation (2009, Homo sapiens)
• The signaling network of differentially expressed proteins (2009, Homo sapiens,clinical samples,Scutellaria baicalensis)
• Dynamic Analysis of IRS-PKR Signaling in Liver Cells: A Discrete Modeling Approach (2009, Saccharomyces cerevisiae,Arabidopsis thaliana,Schizosaccharomyces pombe,Eucalyptus intertexta,Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Oryctolagus cuniculus,Caenorhabditis elegans,Homo sapiens)
• Genes involved in the vitamin D pathway (2009, NA)
• Schematics of the proposed participation of Pi4ka and PI3Ks in the FGF signaling cascade in the developing fin bud mesenchyme (2009, Danio rerio,Homo sapiens)
• Expression of an IKKG Splice Variant Determines IRF3 and Canonical NFKB Pathway Utilization in ssRNA Virus Infection (2009, NA)
• Nephron development and cell lineages (2009, NA)
• Network representation of p53, NFKB and cell cycle interactions (2009, Homo sapiens,Chlorocebus aethiops,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Human immunodeficiency virus 1)
• Cell type-specific functions mediated by decorin via modulation of IGF-IR signaling (2009, NA)
• Master regulator miRNA of oncogenic and tumor suppressor (2009, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human papillomavirus,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Murine leukemia virus,Avian leukosis virus,Human endogenous retrovirus K,Friend murine leukemia virus,Xenotropic MuLV-related virus,Murine endogenous retrovirus,Retroviral provirus,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Zea mays,Olea europaea,Schizosaccharomyces pombe,Aedes aegypti,Dictyostelium discoideum,Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Canis lupus familiaris,NA)
• Diagrammatic representation of non-canonical Wnt signalling in a mammalian cell (2009, NA)
• Planar cell polarity pathway (PCP pathway, non-canonical pathway) cascade (2009, NA)
• Transcriptional control of HC and amacrine cell development (2009, NA)
• Negative-feedback loop linking NAD+/SIRT1 with the Clock network (2009, NA)
• Scaffold-Assisted Catalysis: A Novel Domain In the Ste5 Scaffold Protein is Required to Unlock the MAPK Fus3 for Phosphorylation by the MAPKK Ste7 (2009, NA)
• Model depicting pathways involved in activation and inactivation of nPKCη (2009, NA)
• Metabolism of SFN via the mercapturic acid pathway (2009, Homo sapiens,Rattus norvegicus)
• Regulatory mechanism of the Rho/ROCK pathway activated by angiotensin II (ANG II) in vascular smooth muscles cells (VSMCs, see text) (2009, NA)
• Predictive Phosphorylation Signature of Lung Cancer (2009, NA)
• Drosophila insulin signaling pathway (2009, Drosophila melanogaster,Homo sapiens)
• Hypothalamic Lipids and the Regulation of Energy Homeostasis (2009, NA)
• Metabolic model for Aspergillus niger (2009, NA)
• Inversin functions as a switch between the canonical Wnt and non-canonical Wnt/PCP pathways (2009, NA)
• Wnt/PCP signaling and its effects on organogenesis (2009, NA)
• Cooperativity between CD14 and Mac-1 enhances phagocytocis of B (2009, Bacillus anthracis,Homo sapiens)
• Activation of apoptotic and survival pathways by TNF (2009, NA)
• PRO mapping to the Reactome TGF-beta signaling pathway (2009, NA)
• Transcriptional Regulation of Metabolism Associated With the Increased Desiccation Resistance of the Cactophilic Drosophila mojavensis (2009, Drosophila mojavensis,Homo sapiens)
• Proposed model for the mitogen-activated protein kinase kinase 4 (MEK4) regulation of human prostate cell motility and for its inhibition by genistein (2009, NA)
• All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathways (2009, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Scenario for the application of minimal cut sets (2009, Escherichia coli)
• Metabolic fate of the 13C-label from [1-13C]-glucose (2009, Homo sapiens)
• IFN-gamma signaling pathway (2009, Homo sapiens)
• Proteins upregulated during time course analysis in lung or bronchoalveolar lavage fluid (BAL) following intra tracheal instillation of 20 μg carbon nanopaticles (CNP) (2009, NA)
• Filia's role in ensuring euploidy of early cleavage embryos (2009, NA)
• Diagram depicting the inhibitory and activating effects of OSU-A9 on the Akt–NFKB signaling axis and stress response signaling, respectively (2009, NA)
• Proposed model of the effect of crocetin on cardiac hypertrophy, inflammation and fibrosis (2009, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Triticum aestivum,Crocus sativus,Homo sapiens)
• Inhibition of the l-mevalonate pathway for immunomodulation (2009, NA)
• Graphical representation of the gp130/JAK/STAT pathway (2009, NA)
• Crosstalk between apoptosis and NFKB signaling by IAP-antagonist (2009, NA)
• Various states of pluripotency (2009, NA)
• The type I immune response in M (2009, Mus musculus,Mycobacterium avium,Homo sapiens)
• Schematic drawing showing p38 MAPK activation‐loss of ΔΨm‐ROS generation signalling pathway in toxin‐G‐induced cell death (2009, Naja nigricollis,Homo sapiens)
• Stress-Activated Signaling (SAS) Pathways of a Human Fungal Pathogen, Cryptococcus neoformans (2009, NA)
• Hemopoietic cell survival is regulated by exogenous concentrations of GM-CSF (2009, NA)
• Crosstalk between ionizing radiation-induced apoptosis and NFKB pathway (2009, NA)
• Noteworthy, the inhibition of this pathway through COX-inhibitors leads to induction of apoptosis and tumor growth reduction (Figure ) (2009, NA)
• Schematic model illustrating multiple signaling pathways in regulating StAR gene transcription (2009, NA)
• P2Y receptor signalling could enhance cyst growth (2009, NA)
• Aedeskinin-III signaling to the paracellular pathway in Malpighian tubules of the yellow-fever mosquito (2009, NA)
• Sequence of intracellular events leading from the binding of AVP to its V2 receptor (top) to the insertion of AQP2 water channels into the apical membrane (bottom) (2009, Homo sapiens)
• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,clinical samples,Pyrus communis)
• Regulation of ENaC and CFTR by SGK1/Nedd4-2 (2009, NA)
• Figure shows various cellular targets of radiofrequency electromagnetic waves (RF-EMW) (2009, NA)
• EGFR signaling pathway (2009, Diaporthe sclerotioides,Bikinia letestui,Homo sapiens,Mus musculus)
• Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery (2009, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Calloplesiops altivelis,Serinus canaria,Homo sapiens,Armoracia rusticana,Synthetic phage)
• T cell receptor signaling pathway (2009, Saccharomyces cerevisiae,Arabidopsis thaliana,Capra hircus,Human immunodeficiency virus 1,Human rhinovirus sp.,Tragelaphus oryx,Homo sapiens,Mus musculus,Poecilia sphenops)
• Cellular mechanisms by which flavonoids and their metabolites protect against neuroinflammation and neuronal injury induced by 5-S-Cys-DA, DHBT-1 and related ROS (2009, NA)
• Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors (2009, Homo sapiens,Mus musculus)
• PANTHER Pathway: an ontology-based pathway database coupled with data analysis tools (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Major trends in mRNA expression at 56 days on experimental diets and summary network analysis among genes (2009, Zea mays,Glycine max,Candida dubliniensis,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens)
• Rod Signaling in the Mammalian Retina Travels via Three Routes(Ai) The primary rod pathway (rod → ON bipolar cell→ AII amacrine cell) (2009, Homo sapiens,Rattus norvegicus)
• Molecular pathway analysis of genes regulated in the NAc by the HDAC inhibitor MS-275 after chronic social defeat stress (2009, NA)
• Main pathways associated with response to CR (2009, NA)
• Activation of Akt in the cytoplasm (A) vs (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Bile acids and FGF19 increase stability of hepatic SHP by inhibiting ubiquitin–proteasomal degradation and activating ERK pathway (2009, Mus musculus,Homo sapiens)
• Basic pathway controlling the G1/S transition (2009, Arabidopsis thaliana)
• Mitochondrial dysfunction as an effector mechanism of OIS and replicative senescence (short telomeres) (2009, NA)
• Proposed mechanisms for PDE inhibitor-induced cytoprotection against myocardial ischemia-reperfusion injury (2009, NA)
• Scheme shows some of the potential kinase activity-dependent and scaffold-dependent mechanisms by which GRK2 may modulate epithelial cell migration (2009, NA)
• Steps in the generation of Th17 cells (2009, NA)
• Mechanistic model of unloading-mediated muscle atrophy (2009, NA)
• Endonuclein functions (2009, NA)
• Illustration of differences in the expression of genes for early steps of sphingolipid metabolism using a KEGG-based microarray analysis tool (GenMapp v2.1) that has been modified to display this pathway more completely (www.sphingomap.org) (2009, NA)
• Schema of PGE2-induced apoptosis in lung fibroblasts (2009, Homo sapiens)
• Changes in Akt signaling with differentiation of CD8+ T cells and co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1)-blocked highly differentiated CD8+ T cells (2009, NA)
• Pathway analysis result showing 18 differentially expressed proteins following 50% PH can be sorted into the c-myc pathway (2009, Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Altered insulin signaling by lipid intermediates (2009, NA)
• Circulating blood monocytes adhere to activated endothelium at sites of disease or injury (2009, Homo sapiens)
• New pathway for memory B-cell activation in systemic lupus erythematosus (SLE) (2009, NA)
• Stress-Activated Signaling (SAS) Pathways of a Human Fungal Pathogen, Cryptococcus neoformans (2009, NA)
• Ca2+/calcineurin pathway and Ras-signaling pathway in C (2009, NA)
• Inhibition of the type I interferon (IFN) pathway of Kaposi's sarcoma-associated herpesvirus (KSHV) (2009, NA)
• Repression of TGFB-RII and abrogated signaling through the Smad pathway (2009, NA)
• Sphingosine-1-phosphate (S1P)-mediated regulation of vascular tone (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Expansion of the yeast signaling model using the experiments proposed by MEED (2009, NA)
• Working model for the biochemical cascade leading to the AR (2009, NA)
• Mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects (2009, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Vasconcellea candicans)
• Bile acid modulation of death and survival transduction pathways (2009, NA)
• Hypoxia-invoked response of the glycolysis gene network (2009, NA)
• P53 signaling pathway in response to genotoxic stress in tumorogenic cells (2009, NA)
• Complement system in AD (2009, NA)
• Modified Lee-Heinrich model of wnt pathway (2009, NA)
• Cannabinoid CB1 Receptor-Dependent Long-Term Depression in Autaptic Excitatory Neurons (2009, Mus musculus,Homo sapiens)
• Proposed TLR signaling network modified from previous reports (; ; ) (2009, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Respiratory syncytial virus,Vaccinia virus,H5N1 subtype,Ebola virus,Enterovirus C,Variola virus,SARS coronavirus NS-1,H9N2 subtype,Influenza B virus,Norwalk virus,Mycobacterium tuberculosis,Lareunionomyces loeiensis,Arachis hypogaea,Haemophilus influenzae,Yersinia pestis,Cystobasidium portillonense,Caenorhabditis elegans,Patella vulgata,Homo sapiens,Mus musculus,Gallus gallus,NA,NA)
• Trx-ASK1 pathway of ROS mediated regulation of the p38 MAPK stress response pathway (2009, NA)
• Metabolic map of HIF-target genes (2009, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Equus caballus,Elephas maximus,Ornithorhynchus anatinus,Tupaia glis,Gallus gallus,Danio rerio,Oryzias latipes,Zootoca vivipara,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,Diaporthe sclerotioides,Pan troglodytes,Caenorhabditis elegans)
• The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis (2009, NA)
• Inhibition of the calcineurin-NFATc pathway at multiple levels (2009, NA)
• Schematic overview about TCR-dependent signalling pathways (2009, NA)
• DISC1 regulates neurogenesis via Wnt/Beta-catenin signaling (2009, NA)
• DISC1 at the synapse (2009, NA)
• Modulations in AMPK activity, glucose transport, and Δψm in response to the energetic stress created by transient glutamate excitation (2009, NA)
• ANG II-dependent and independent pathways for renin signaling (2009, NA)
• The assembly of 14-3-3:Shc scaffolds (2009, Mus musculus,Homo sapiens)
• Loss of PTEN function results in accumulation of PIP3, which activates a cascade of signaling molecules (2009, NA)
• Regulated molecules in canonical signalling pathways identified by IPA (2009, Campylobacter jejuni,Homo sapiens)
• Schematic depicting proposed mechanisms by which the nucleoside adenosine elicits an adenoprotective action in the myocardium (2009, NA)
• Regulation of osteogenic differentiation of MC3T3-E1 cells by substrate rigidity (2009, Mus musculus,Homo sapiens)
• Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder (2009, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Corvus corax)
• Effect of dasatinib on the BCR-ABL signaling pathway (2009, NA)
• Novel functional modules with dynamic gene expression changes potentially linked to prion pathophysiology: (A) androgen metabolism, (B) iron metabolism, (C) arachidonate/phospholipid metabolism (2009, NA)
• Met signal transduction exploited by InlB from L (2009, Listeria monocytogenes,Homo sapiens)
• Proposed pathway (2009, Homo sapiens,Mus musculus)
• The postreceptor insulin signaling pathway and insulin-independent 5′-adenosine monophosphate kinase (AMPK) beginning from insulin binding to its receptor to GLUT4 translocation via vesicular trafficking (2009, Rattus norvegicus,Homo sapiens)
• Akt pathway activation leading to VCAM-1 expression in HIMEC (2009, NA)
• Regulation of hepatic glucose metabolism and cholesterol and fatty acid biosynthetic pathways by bile acids (2009, Homo sapiens)
• Coordinated upregulation of cytoprotective genes occurs as a result of Nrf2 activation (2009, NA)
• Signaling in the PI3K/Akt pathway and deregulations detected in GRMD skeletal muscle (2009, Homo sapiens,Canis lupus familiaris)
• Neuroimmune interactions of kynurenine intermediates (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Reciprocal misregulation of 24p3 and 24p3R expression by BCR–ABL (2009, NA)
• Pathway showing genes involved in Parkinson's disease (Courtesy: KEGG pathway) (2009, NA)
• Signaling in pterygium (2009, Homo sapiens,Sequoia sempervirens)
• Proposed model of estrogen's anti-inflammatory and pro-survival actions in the brain following severe burn injury (2009, NA)
• Metabolic pathways and 13C labeling patterns related to reverse flux through pyruvate kinase in skeletal muscle after [U-13C3]lactate administration (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Caspases in promoting the pathology associated with AD (2009, NA)
• Current working model of the signaling pathway components (shaded areas) that are differentially regulated in C57 and CD-1 pup brain tissues and cultured NSCs under normoxic and hypoxic (Hx) conditions (2009, NA)
• NO can both protect and sensitize cells to excitotoxic cell death through a mitochondrial pathway (2009, NA)
• Proposed consequences of impaired insulin signaling in AD brain and in the STZ-injected rat brain (2009, NA)
• New Microbicidal Functions of Tracheal Glands: Defective Anti-Infectious Response to Pseudomonas aeruginosa in Cystic Fibrosis (2009, NA)
• Activation of the Akt (insulin signaling pathway) and FXR by bile acids in hepatocytes (2009, Homo sapiens)
• Major cell signaling pathways activated by bile acids in hepatocytes (2009, Homo sapiens)
• IMP impedes Ras mitogenic signaling by limiting KSR1 complexes (2009, NA)
• Canonical TCR signaling pathway (2009, NA)
• An example of combined analysis of three identified regulatory modules (2009, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Human alphaherpesvirus 1,Middle East respiratory syndrome-related coronavirus,Pan troglodytes,Danio rerio,clinical samples,NA)
• Nodal signaling pathway (2009, NA)
• Coordination of extracellular and intracellular signaling regulates cytoskeletal dynamics and axon formation (2009, NA)
• How NFKB DNA binding is regulated by IKB degradation and processing following activating stimuli (2009, NA)
• Diagrammatic representation of intracellular pathways that lead to the production of IL-12p40 and the mechanisms of azithromycin (AZM) to inhibit the expression of IL-12p40 upon the stimulation of LPS/IFNG (2009, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana,Escherichia coli O111)
• EGFR Signaling Pathway (2009, NA)
• Signaling by pleckstrin leading to platelet activation (2009, Mus musculus,Homo sapiens)
• Representation of selected metabolic pathways induced in –P-stressed nodules (2009, Rhizobium tropici,Rhizobium tropici CIAT 899,Homo sapiens,Phaseolus vulgaris)
• Roles of ROS in the Ras-Raf-MEK-ERK signaling and p38 pathway (Modified from Ref (2009, NA)
• The proposed model (2009, Mus musculus,Homo sapiens)
• Major pathway and inflammatory mediators of sepsis and its related conditions (2009, NA)
• Principles in TLR signaling (2009, NA)
• Integration of the Beta-Catenin-Dependent Wnt Pathway with Integrin Signaling through the Adaptor Molecule Grb2 (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Chlorocebus aethiops,Drosophila melanogaster,Pseudomonas phage PRR1)
• The signaling pathway of IL-1Beta-induced MCP1 expression in HASMCs (2009, Homo sapiens)
• Model for a negative feedback mechanism of Wnt signal transduction by GBG signaling (2009, Xenopus laevis,Homo sapiens)
• Pathways involved in NOR-1 upregulation by thrombin and VEGF (light lines) and hypoxia (bold lines) in endothelial cells (2009, NA)
• Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia (2009, NA)
• Defective respiration of Δisc1 in the post-diauxic phase (2009, Saccharomyces cerevisiae,Homo sapiens)
• Signaling networks upregulated in migrating neuroblasts (2009, NA)
• Model: a Src-Tks5-Nck signalling pathway in invadopodia (2009, NA)
• Proposed pathway for polyoxin biosynthesis (2009, Streptomyces cacaoi)
• The PI3k/Akt signaling pathway depicting the possible sites of action by the PI3k inhibitors LY294002 and wortmannin and the Akt inhibitors Akt-VIII, Akt-V, and Akt-IV (2009, NA)
• Dynamics of Membrane Trafficking Downstream of B and T Cell Receptor Engagement: Impact on Immune Synapses (2009, Homo sapiens,Mus musculus)
• CWI pathway (2009, Homo sapiens,Saccharomyces cerevisiae)
• The signaling pathway of AngII-induced aldosterone production mediated by Barr1 (2009, Rattus norvegicus,Homo sapiens)
• Microglia Are Mediators of Borrelia burgdorferi–Induced Apoptosis in SH-SY5Y Neuronal Cells (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Panthera leo,Salmonella enterica subsp. enterica serovar Typhimurium,Borreliella burgdorferi,Treponema pallidum,Homo sapiens,Macaca mulatta,Mus musculus,Armoracia rusticana)
• The signaling pathways downstream of NK1R (2009, NA)
• The proposed mechanism of induction of proasthmatic changes in ASM responsiveness following prolonged homologous B2AR desensitization (2009, Homo sapiens,Oryctolagus cuniculus)
• iNOS pathway (2009, NA)
• SCFA-analog hybrids enhance cellular uptake and endow analogs with novel activities (2009, NA)
• Selective pathway utilization of analogs is ensured by the nonpermissivity of enzymes at critical junctures (2009, NA)
• Mammalian sialic acid metabolism (2009, NA)
• Origin of Notch signalling pathway components in Unikonta (modified from ) (2009, NA)
• Major components and auxiliary factors of the Notch signalling pathway as described in Bilateria (modified from ) (2009, NA)
• Proposed biosynthetic pathways for the generation of AEA from its arachidonoyl containing NAPE (NArPE) precursor (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Cannabis sativa)
• Metabolic pathway map for vitamin D2 using GeneGo MetaCore™ (2009, Homo sapiens)
• Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice (2009, NA)
• Smad4: gatekeeper gene in head and neck squamous cell carcinoma (2009, Mus musculus,NA,Homo sapiens)
• Acromegaly pathogenesis and treatment (2009, NA)
• Human protein-protein interaction network of aging-associated genes (2009, Saccharomyces cerevisiae,PX clade,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• BANs of differentially expressed genes in common between cell lines (2009, Mus musculus,Rattus norvegicus,Armoracia rusticana,Nicotiana tabacum,Diaporthe sclerotioides,Cricetulus griseus,Homo sapiens,Bos taurus,Drosophila melanogaster)
• F igure 1.— (2009, Drosophila melanogaster,Homo sapiens)
• HERPUD1 Ingenuity Pathway Analysis illustrates interactions between indicated proteins (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Venustaconcha ellipsiformis,Camelpox virus)
• Insulin-induced IFN resistance (2009, NA)
• miR-331-3p blocks AR signaling via inhibition of ERBB-2 expression and AKT activity in prostate cancer cells (2009, NA)
• Role of clathrin adaptor proteins in melanosome biogenesis (2009, Homo sapiens)
• The proposed mechanism for Spred (2009, Xenopus laevis,Xenopus tropicalis,Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus)
• CaV2.2 model system to be tested by NK-1R activation (2009, Homo sapiens,Rattus norvegicus,Diaporthe sclerotioides,Xenopus laevis,Prevotella sp.)
• Mechanisms involved in lipid modulation of voltage-gated N- and L-type calcium channels by the slow pathway (2009, Homo sapiens,Rattus norvegicus)
• Schematic illustration demonstrating signaling pathways involved in CCL2-mediated neuroprotection in rat primary neurons (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Corynephage beta)
• Eukaryotic gene expression is controlled by multiple mechanisms, and its regulation is central for physiological responses to extracellular and intracellular signals (2009, NA)
• Proposed mechanism to explain the downregulation of miR-1 and miR-133a by insulin in human skeletal muscle (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Proposed model for possible mechanism of MUC4-mediated resistance to apoptosis (2009, NA)
• EXT/HSPG pathway involved in both peripheral and central chondrosarcomas (2009, NA)
• Epithelial SC compartments in the mammalian intestine and the skin and Wnt signaling in SCs (2009, NA)
• Apical endoplasmic reticulum and mucin secretory granules (2009, NA)
• Pathway for synthesis of native and foreign lipids in E (2009, NA)
• Putative BK-BKAP interactions derived from the BK interactome in mouse cochlea (2009, Homo sapiens,Mus musculus)
• Application of SysPTM tools (2009, NA)
• Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs (2009, Bos taurus,Sus scrofa,Ovis aries,Eutheria,Metatheria,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• P2X7R-induced signalling pathway involved in MP shedding and large pore opening in glial cells (2009, NA)
• 3 mechanistic pathways known to be disturbed in patients with pulmonary arterial hypertension (PAH) (2009, NA)
• Beta-catenin regulation and function in less contracted and more contracted clubfoot tissues (2009, NA)
• Expanded canonical Wnt/GSK3 signaling pathway (2009, Xenopus laevis,Homo sapiens)
• TGFB transduces signaling through Smad and non-Smad signaling pathways (2009, NA)
• Regulation of Neurogenesis by DISC1 (2009, NA)
• Adipocyte lineage commitment and terminal differentiation (2009, Mus musculus,Homo sapiens)
• Silent chromatin assembly in budding and fission yeast (2009, NA)
• MAPK transduction signaling pathway (2009, Homo sapiens)
• Differentiation-Inducing Factor-1 and -2 Function also as Modulators for Dictyostelium Chemotaxis (2009, Dictyostelium discoideum,Dictyostelium discoideum AX2,Homo sapiens)
• Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional Program (2009, NA)
• Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling (2009, NA)
• Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling (2009, NA)
• Wnt therapy for bone loss: golden goose or Trojan horse? (2009, NA)
• Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders (2009, NA)
• Genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders (2009, NA)
• Bipolar disorder: from genes to behavior pathways (2009, Homo sapiens,Mus musculus)
• Cell proliferation and apoptosis (2009, Homo sapiens,Mus musculus)
• Increased Insulin/Insulin Growth Factor Signaling Advances the Onset of Metamorphosis in Drosophila (2009, NA)
• EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis† (2009, Caenorhabditis elegans,Giardia intestinalis,Homo sapiens,Mus musculus,Bos taurus)
• Signaling pathways triggered by TLR3, TLR4 and TLR1–TLR2 (2009, Homo sapiens)
• S1P receptor-mediated signalling in the heart (2009, NA)
• Regulation and function of sphingosine kinase-1 (SK1) (2009, NA)
• Where Do MAIT Cells Fit in the Family of Unconventional T Cells? (2009, Homo sapiens,Mus musculus)
• Hypergraph representation of the Boolean model for yeast glucose repression (2009, Saccharomyces cerevisiae,Homo sapiens)
• In endothelial cells, after activation, VEGFR2 is able to stimulate the AKT/mTOR signalling pathway through PI3K (2009, NA)
• Amino acid producing elementary flux patterns (2009, Escherichia coli)
• Proposed model for the interaction between PyVmT and IR or IGF-IR (2009, Mouse mammary tumor virus,Polyomavirus sp.,Merkel cell polyomavirus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Escherichia coli,Matthiola incana)
• Modes of neurite growth inhibition of molecules expressed on CNS myelin and oligodendrocytes (2009, Homo sapiens)
• Hypothetical model for the end-joining mechanisms during CSR (2009, NA)
• Corticosterone (CORT) binds to a yet-uncharacterized membrane-bound glucocorticoid receptor (mbGR) that activates the Gs–cAMP/PKA pathway to induce endocannabinoid (eCB) synthesis (2009, NA)
• Network analysis using Ingenuity pathway analysis (IPA) software (2009, Homo sapiens,Nicotiana tabacum,Human papillomavirus)
• NFKB/IKB complex leading to NFKB activation (2009, Curcuma longa,Phyllanthus emblica,Phyllanthus acidus,Staphylococcus aureus,Pseudomonas aeruginosa,Homo sapiens,Mus musculus)
• Hypothetical signaling pathway linking cytochrome P-450 (CYP) 4 activation and 20-HETE-induced protection from apoptosis (2009, NA)
• Calcineurin-NFAT signaling pathway (2009, NA)
• Dual-signaling pathways regulated by Shp2 (2009, Homo sapiens,Mus musculus)
• Genome-Wide Screen of Genes Required for Caffeine Tolerance in Fission Yeast (2009, Saccharomyces cerevisiae,Escherichia coli,Pseudomonas aeruginosa,Candida albicans,Schizosaccharomyces pombe,Escherichia coli IS1,Homo sapiens,Oryctolagus cuniculus,His2 virus)
• Summary of consequences on signal transduction and brain architecture of conditional Pten or Pdk1 deletion, alone or in combination (2009, NA)
• Sample signalling scheme showing pathways known to be active in melanoma (2009, Homo sapiens,Mus musculus)
• Diagram for the non-canonical MEK/ERK signaling pathway regulating autophagy via regulating Beclin 1 (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• The TSC-mTOR signaling (2009, NA)
• Enrichment of Jak-STAT signaling pathway (2009, NA)
• Enrichment of MAPK signaling pathway (2009, NA)
• Enrichment of TGF-beta signaling pathway (2009, NA)
• Enrichment of Wnt signaling pathway (2009, NA)
• An overview of Wnt-5a signalling (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Experimental results of Rap1 pathway knockout from Falco et al (2009, NA)
• Network analysis of differentially expressed proteins (red symbols) involved in arteriogenesis (2009, NA)
• Activation of the G2/M checkpoint after DNA damage (2009, Homo sapiens,Mus musculus,Drosophila melanogaster,Nicotiana tabacum,NA)
• New model of EGF activated ERK pathway: This is a schematic of our new model of the EGF activated ERK pathway which was developed from the original EGF model (2009, NA)
• Cooperation of Mtmr8 with PI3K Regulates Actin Filament Modeling and Muscle Development in Zebrafish (2009, Gallus gallus,Danio rerio,Paralichthys olivaceus,Carassius gibelio,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Capra hircus,Moloney murine leukemia virus)
• The EGF activated ERK pathway: This is a schematic of the EGF activated ERK pathway beginning at the level of EGF binding to EGFR and finishing at the level of ERK; see the text for more details on the features and functions of the pathway (2009, NA)
• Detection of WNV and activation of IFNA/B genes and ISG according to the 2-step model (2009, NA)
• ATM activation in response to DNA DSBs (2009, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster,Human immunodeficiency virus 1,Dipturus trachyderma,Escherichia phage T7)
• The potential consequences of the presence of KSHV-induced ANG for the infected endothelial cell population (2009, Homo sapiens,Human gammaherpesvirus 8,NA)
• Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways (2009, NA)
• Proposed model for the signaling pathway of Cao-induced keratinocyte differentiation (2009, NA)
• Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease (2009, Homo sapiens)
• Gene Expression in Skeletal Muscle Biopsies from People with Type 2 Diabetes and Relatives: Differential Regulation of Insulin Signaling Pathways (2009, NA)
• Exocytic signal conferred by PI signaling and regulation of the actin cytoskeleton (2009, NA)
• IGF2 effects on colonic epithelia (2009, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• The IGF2 signaling pathway (2009, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• Proposed model for EGFR-related signal transduction pathways regulating Snail in Ishikawa (A), Ishikawa ER- (B) and primary human endometrial tumours (C) (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Foetal liver-placenta-maternal liver excretory pathway (2009, NA)
• Wnt/Beta-catenin pathway (2009, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• DUOX1 involvement in TLR-mediated IL-8 production in response to bacterial stimuli (2009, NA)
• Regulation of mammalian target of rapamycin (mTOR) signaling functions (2009, Homo sapiens)
• The hypothetical mechanisms involved in fibronectin-induced P2X4R up-regulation in microglia (2009, NA)
• Anaerobic metabolic pathways in C (2009, NA)
• Predicted general metabolism and solute transport in T (2009, NA)
• Multiple regulatory pathways for N-WASP and WAVE2 activation (2009, Drosophila melanogaster,Caenorhabditis elegans,Dictyostelium discoideum,Saccharomyces cerevisiae,Arabidopsis thaliana,Danio rerio,Dipnomorpha,Homo sapiens,Mus musculus)
• This schematic shows the numerous pro-inflammatory mediators produced by peri-implant tissue and immune cells reacting to implant debris, which can negatively affect bone turnover (2009, NA)
• Metabolic reprogramming in tumor cells (2009, Homo sapiens,Mandrillus leucophaeus)
• Uncoupling of the LKB1-AMPKA Energy Sensor Pathway by Growth Factors and Oncogenic BRAFV600E (2009, NA)
• Possible site for alcohol-induced inhibition of muscle protein synthesis (2009, NA)
• The role of Mal connecting PI3K to TLR2/6 (2009, NA)
• c-Src Regulates Akt Signaling in Response to Ghrelin via Beta-Arrestin Signaling-Independent and -Dependent Mechanisms (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Innate immune response (2009, Caenorhabditis elegans,Homo sapiens)
• Clusterin as a critical signaling node (2009, NA)
• Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions (2009, Mus musculus,Homo sapiens)
• Beta-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in Motor Neurons (2009, Homo sapiens,Caenorhabditis elegans)
• A potential model for estradiol-induced GCH1 transcription in PAECs (2009, NA)
• Iron acquisition pathway in developing erythroblasts The Fe(III)-Tf complex binds to specific receptors present on the cell surface, inducing the formation of an endocytic vesicle (2009, Homo sapiens,Mus musculus)
• Conversations between Wnt/Beta-catenin and MAPK signaling pathways (2009, NA)
• Wnt/-catenin signaling pathway (2009, NA)
• Insulin-PI3K-Akt signaling in AD (2009, Mus musculus,Homo sapiens)
• Models of RAF/MEK/ERK signaling in tumor cells with RTK activation and with V600EBRAF (2009, NA)
• Molecular interaction map displaying the functional interaction of genes in the MEK/ERK output profile with established roles in ERK signaling (2009, NA)
• KLF14-mediated TGFBRII silencing (2009, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Bikinia letestui)
• PD-1 tempers Tregs in chronic HCV infection (2009, NA)
• Schematic showing signaling mechanism of B3 integrin-mediated Ub for NFKB activation and cIAP1 expression during compensatory cardiac hypertrophy (2009, Mus musculus,Felis catus,Homo sapiens)
• Pathway mapping of OPC differentiation inducer genes (2009, NA)
• Signaling Logic of Activity-Triggered Dendritic Protein Synthesis (2009, NA)
• Signalling pathways involved in skeletal muscle remodelling and atrophy following disuse (2009, NA)
• Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation (2009, NA)
• Two main pathways involved in apoptosis regulation (2009, NA)
• Proposed model involving GSK-3 inhibition and the mTOR pathway to stimulate human Beta-cell growth and proliferation (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Xenopus laevis,Hypostomus robinii,Homo sapiens)
• Activation of Alpha-secretase as a target for the therapy of Alzheimer’s disease (2009, Homo sapiens)
• Model showing RBR3 role in the RBR/E2F pathway controlling the expression of MCM2–7 genes, DNA replication, and cell transformation (2009, Zea mays,Adenoviridae)
• Pathogenetic mechanisms of CCAAT enhancer binding protein alpha (C/EBPA) dysfunction (2009, Homo sapiens)
• Genomic position of the FGFRL1, FGF8/17/18 and FGFR orthologues in several metazoan species (2009, NA)
• T-Cell Activation Pathways Generated by HIV-Modulated Proteins (2009, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Dengue virus,Human gammaherpesvirus 8,Murine leukemia virus,Feline sarcoma virus,Pseudocowpox virus,Rasheed rat sarcoma virus,Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Escherichia coli,Drosophila melanogaster,Gallus gallus,Olea europaea,Corynephage beta,NA,NA)
• Signal pathways regulating hyaluronan secretion into static and cycled synovial joints of rabbits (2009, Oryctolagus cuniculus,Homo sapiens)
• The PI3K/Akt/mTOR pathway (2009, NA)
• F igure 6.— (2009, Saccharomyces cerevisiae,Homo sapiens)
• Molecular Profiling Reveals Diversity of Stress Signal Transduction Cascades in Highly Penetrant Alzheimer's Disease Human Skin Fibroblasts (2009, Mus musculus,Bos taurus,Oryctolagus cuniculus,Cricetulus griseus,Homo sapiens)
• Working model (2009, NA)
• TPA's role in acute cocaine-induced neuronal signaling (2009, NA)
• Homologies between mammalian and insect immune defense pathways (2009, NA)
• Proposed integrated model for local water transport inhibition by activation of P2Y2 and adenosine A1 receptors (A1R) in inner medullary collecting duct principal cell (2009, Mus musculus,Homo sapiens)
• Apoptin-activated signaling (2009, Mus musculus,Chicken anemia virus,Homo sapiens)
• Visualization of molecular interaction and reaction networks in the KEGG database (2009, NA)
• Investigating Differential Dynamics of the MAPK Signaling Cascade Using a Multi-Parametric Global Sensitivity Analysis (2009, NA)
• Transcriptional activation of DNA repair mediated by UPS-dependent pathways (2009, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,NA)
• Metabolic pathway for PhIP activation and induced mutations (2009, NA)
• Single-strand break repair pathways (2009, NA)
• Model whereby increased Fgfr3 signaling in chondrocytes causes premature synchondrosis closure and unification of ossification centers (2009, Homo sapiens,Mus musculus)
• Links between MAP kinase signaling cascades and control of LDL receptor expression in HepG2 cells (2009, NA)
• EGFR signal transduction pathways (2009, Orf virus,Avian erythroblastosis virus,Homo sapiens,Mus musculus,NA)
• EGFR signaling pathways (2009, Orf virus,Avian erythroblastosis virus,Homo sapiens,Mus musculus,NA)
• Gene RE frequencies in the cell cycle pathway (2009, NA)
• Toll-like receptor (TLR) signaling (2009, NA)
• Epidermal growth factor receptor (EGF-R)-signaling pathway and predictive biomarkers for the efficacy of EGF-R antibodies (2009, Homo sapiens)
• Transcriptional modifications of DNA repair by UPS in response to cellular stressing conditions (2009, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,NA)
• Different levels of HDAC-mediated control in the p53 pathway (2009, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Hepatitis B virus,Homo sapiens,Saccharomyces cerevisiae)
• Pathways and networks associated with HSPA9, PHB, and ABCB6 (2009, NA)
• MiRNA/TF-mediated regulatory pathway associated with tumorigenesis (2009, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• RST inhibits the first step of cholesterol/isoprenoid biosynthesis by blocking 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, thus reducing the formation of mevalonate from HMG-CoA (2009, Rattus norvegicus,Homo sapiens)
• Adaptor protein containing pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif (APPL1)-mediated adiponectin and insulin-signaling pathways (2009, NA)
• Phylogenomics of Sterol Synthesis: Insights into the Origin, Evolution, and Diversity of a Key Eukaryotic Feature (2009, NA)
• Diagram of working hypothesis illustrating the mechanisms of HO-2-dependent excitation to hypoxia (hypoxic hypoxia and NaCN) (2009, NA)
• Activation of complement system by the amyloid plaques and its dual role in neuronal death (2009, NA)
• Common features of host-Flaviviridae interactions (2009, Homo sapiens)
• Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network (2009, NA)
• Highly simplified schematic of PKA involvement in the AHP reduction after learning (2009, Rattus norvegicus,Homo sapiens)
• LPA effect and signal transduction pathway (2009, NA)
• Rev-erbA/PGC-1A pathway regulating heme homeostasis (2009, Mus musculus,Homo sapiens)
• Proposed VEGF-C/D cell signaling pathway to transduce LAM cell proliferation (2009, NA)
• Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling (2009, Escherichia coli,Helicobacter pylori,Streptococcus pneumoniae,Pyrococcus furiosus,Homo sapiens,West Nile virus)
• Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling (2009, Escherichia coli,Helicobacter pylori,Streptococcus pneumoniae,Pyrococcus furiosus,Homo sapiens,West Nile virus)
• Proposed scheme of the signaling pathway leading to immature dendritic cell chemotaxis upon exposure to M-tropic gp120 (2009, Human immunodeficiency virus 1)
• Decreased glucose regulates action potential frequency of VMH GI neurons (2009, Mus musculus,Rattus norvegicus,Homo sapiens)
• Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling (2009, Escherichia coli,Helicobacter pylori,Streptococcus pneumoniae,Pyrococcus furiosus,Homo sapiens,West Nile virus)
• Identification of Potential Pathway Mediation Targets in Toll-like Receptor Signaling (2009, Escherichia coli,Helicobacter pylori,Streptococcus pneumoniae,Pyrococcus furiosus,Homo sapiens,West Nile virus)
• Endogenous Cardiotonic Steroids: Physiology, Pharmacology, and Novel Therapeutic Targets (2009, Homo sapiens)
• Canonical Wnt (Wnt/Beta-catenin) signaling pathway (adapted from Ref (2009, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• NFKB signal transduction (2009, Homo sapiens,Mus musculus)
• Strategies to inhibit the VEGF signalling pathway (2009, Homo sapiens,Mus musculus,Chrysichthys cranchii)
• AMPK–p53 pathway in metabolic adaptation (2009, NA)
• Most prominently affected gene network in response to FA in TM 93 cells (2009, NA)
• Most prominently affected gene network in response to DEX in TM 86 cells (2009, NA)
• Metabolic pathways of growth and proliferation (2009, NA)
• AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease (2009, NA)
• Scheme of part of the central metabolism of E (2009, Escherichia coli)
• Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans (2009, Candida albicans,Homo sapiens)
• Cellular Prion Protein Interacts with the Tissue Non-Specific Alkaline Phosphatase in Membrane Microdomains of Bioaminergic Neuronal Cells (2009, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,prion)
• Molecular mechanisms of androgen action (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• LPS signaling [modified from O’Neill and Bowie () with permission] (2008, NA)
• MiRNA Signature of Prion Induced Neurodegeneration (2008, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Bos taurus,Escherichia coli,Arabidopsis thaliana,Human immunodeficiency virus 1,prion)
• FGF canonical signalling pathway (2008, NA)
• Schema illustrating the effects of (a) metformin- or AICAR-induced AMPK activation, (b)adiponectin, and (c) TZDs or PPAR alpha ligands on the rat granulosa cell steroidogenesis (2008, Bos taurus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Gallus gallus)
• Proposed biosynthetic pathway for cylindrospermopsin (see text for detail) (2008, Cylindrospermopsis raciborskii AWT205)
• Proposed model of APL pathogenesis induced by PML-RARA (2008, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Escherichia coli,Drosophila melanogaster,Enterobacteria phage R17)
• Adult stem cell maintenance and tissue regeneration in the ageing context (2008, NA)
• Prostate cancer and HGPIN and depicting their interrelationships with the mTOR pathway (2008, NA)
• An outline of major signaling pathways leading to NFKB activation (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 4)
• Programmed cell death can be executed via extrinsic and intrinsic pathways depending on the stimulus leading to apoptosis (2008, NA)
• NFKB pathway in skeletal muscles (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 4)
• Type I Interferon: Potential Therapeutic Target for Psoriasis? (2008, NA)
• Notch1, p53, and HMGA1 interplay in normal and HPV-infected keratinocytes (2008, Homo sapiens,Human papillomavirus)
• Proposed model for the cAMP-dependent signaling events involved in the neurotrophic actions of PACAP-38 on SH-SY5Y cells (2008, NA)
• Coexpression of the genes for fatty acid biosynthesis (2008, Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Embryophyta,Solanum tuberosum,Brassica napus,Escherichia coli,Escherichia coli 85B,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• The signaling pathways regulating cell cycle and differentiation in tumor cells in response to shear stress (2008, Homo sapiens)
• PPARA/p16INK4a Pathway inhibits Vascular Smooth Muscle Cell Proliferation by repressing Cell Cycle-dependent Telomerase Activation (2008, NA)
• Simplified native E (2008, Escherichia coli,Staphylococcus aureus)
• Leucine degradation pathway in mitochondria (2008, Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Embryophyta,Solanum tuberosum,Brassica napus,Escherichia coli,Escherichia coli 85B,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Inhibition mechanism of BMS-345541 and Purvalanol A in HTLV-1 infected cells results in blocking canonical NFKB signaling pathway and cell cycle progression (2008, NA)
• Proposed pathway.In this model, IGF-I peptide binds to IGF-IR to induce tyrosine autophosphorylation and phosphorylation of its adaptor protein Shc (2008, Homo sapiens)
• The major pathways leading to apoptosis (2008, NA)
• Two pathways that promote axon formation by regulating SAD activity or SAD protein levels (2008, NA)
• Scheme of the Wnt signaling pathway (2008, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Molecular ablation of TGFB signaling pathways by tyrosine kinase inhibition: The coming of a promising new era in the treatment of tissue fibrosis (2008, NA)
• Pathway Engineered Enzymatic de novo Purine Nucleotide Synthesis (2008, Escherichia coli,Escherichia coli K-12,Escherichia coli DH5alpha,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Diaporthe sclerotioides,Human immunodeficiency virus 2,Gallus gallus,Homo sapiens)
• Cystic fibrosis and estrogens: a perfect storm (2008, Homo sapiens)
• Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling (2008, Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Caenorhabditis elegans)
• Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD (2008, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Drosophila melanogaster,Raphanus sativus,NA,NA)
• Kinetic model of the EpoR/GATA-1 network implicated in erythrocyte progenitor commitment (2008, NA)
• Summary of possible IL-24-induced effects (2008, NA)
• Role of purinergic receptors in regulation of insulin secretion in the B cell (2008, NA)
• Cell death (2008, Mus musculus,Rattus norvegicus,Adeno-associated virus,Sindbis virus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,Gallus gallus)
• Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape (2008, NA)
• Proposed model of p120 action (2008, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Bikinia letestui)
• Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape (2008, NA)
• Regulation of neuroinflammation by PPAR agonists in CNS diseases (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of NFKB pathway by PPAR agonists in CNS diseases (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular pathways of rheumatoid arthritis-related cartilage destruction as reflected by the in vitro model (2008, NA)
• IL-12, IL-23 and IL-27 are heterodimeric cytokines signals through Jak-Stat pathway and induce Th1/Th17 differentiation and T-bet expression in T cells (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt canonical signaling pathway (2008, Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Human papillomavirus types,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Wnt signaling pathwhay in cervical cancer (2008, Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Human papillomavirus types,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• TNFA signaling pathway (2008, NA)
• Balance between muscle hypertrophy and atrophy depends on whether protein synthesis is more active than degradation or vice versa (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Regulatory network of important genes involved in EBV-dependent NPC (2008, NA)
• Several molecular features in the cell body of an oxidatively stressed neuron (2008, NA)
• Intersection sets of the differentially expressed miRNAs constitute complex interaction networks.A Venn diagram illustrating the production of intersection sets from three miRNA target prediction algorithms (2008, NA)
• InterferonG signaling pathway and mutations in its components found in human uterine leiomyosarcoma (2008, NA)
• MAPK Signaling Cascade is a Central Hub in the Regulation of Cell Cycle, Apoptosis and Cytoskeleton Remodeling by Tripeptidyl-Peptidase II (2008, NA)
• Left, the mechanism, described by , for the proapoptotic function of TSP1 or 2 (2008, NA)
• Roles of the ILS pathway and HSF1 in aggregation toxicity and longevity (2008, NA)
• Some putative molecular mechanisms that underlie the antineoplastic activity of mesalazine (2008, NA)
• Translating insights from the cancer genome into clinical practice (2008, NA)
• Computational and Experimental Analysis of Redundancy in the Central Metabolism of Geobacter sulfurreducens (2008, NA)
• Networks top-ranked by Ingenuity Pathway analysis after knockdown of TP53 (A) and LSR1+TP53 (B) (2008, NA)
• Activation pathways of the complement system and complement regulatory proteins (2008, NA)
• Mechanism of action of sorafenib (2008, NA)
• Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR1 (A-B) (2008, NA)
• Networks top-ranked by Ingenuity Pathway analysis after knockdown of LSR2 (A-B) (2008, NA)
• Distinct Isoforms of Phospholipase A2 Mediate the Ability of Salmonella enterica Serotype Typhimurium and Shigella flexneri To Induce the Transepithelial Migration of Neutrophils (2008, NA)
• Schematic diagrams of small intestine mucosa in normal and infected intestines (2008, NA)
• Exercise-induced transcription of the Pgc-1A gene in skeletal muscle (2008, Mus musculus,Homo sapiens)
• Src-mediated signaling pathway leading to RPTC proliferation (2008, Mus musculus,Homo sapiens)
• Key pathways in hepatocarcinogenesis and molecularly targeted agents currently under investigation in treatment of advanced HCC (2008, Mus musculus,Rattus norvegicus,Hepatitis B virus,Hepatitis C virus genotype 1,Homo sapiens,Nicotiana tabacum,NA)
• Molecular toll-like receptors (TLRs) of the human gastrointestinal (GI) tract which act as sensors and are the first responders in the major pathway by which the immune system detects infection or damaged tissue (2008, NA)
• Colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition (2008, prion,Homo sapiens)
• IFNB activated pathway (2008, NA)
• Graphical representation of connections between receptors and pathways implicated in NTS baroreflex modulation by pharmacological studies (2008, Rattus norvegicus,Homo sapiens)
• Genomic dissection of the cytokine-controlled STAT5 signaling network in liver (2008, NA)
• Role of cytokines in DC and T-cell interactions (2008, NA)
• Diversification of the innate immune arsenal in amphioxus (2008, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Ciona intestinalis,Branchiostoma lanceolatum,Strongylocentrotus purpuratus,Nematostella vectensis,Deuterostomia,Branchiostoma floridae,Gallus gallus,Danio rerio,Xenopus laevis,Xenopus tropicalis,Takifugu rubripes,Tetraodon nigroviridis,Tetraodon fluviatilis,Homo sapiens,Mus musculus,Canis lupus familiaris)
• GHRP-PPAR pathway in macrophages (2008, NA)
• Schematic of signaling pathways in PDAC (2008, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Insulin-like growth factor-I signaling pathway involved in breast cancer (2008, NA)
• Germline Mutations and Variants in the Succinate Dehydrogenase Genes in Cowden and Cowden-like Syndromes (2008, Homo sapiens)
• Interfering the PI3K/mTOR/p70S6K signaling pathway (2008, Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus,Betapolyomavirus macacae)
• HIV Replication Enhances Production of Free Fatty Acids, Low Density Lipoproteins and Many Key Proteins Involved in Lipid Metabolism: A Proteomics Study (2008, NA)
• TLR pathway and interactions with the specific immune response (2008, NA)
• Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) and the Slm1 and Slm2 proteins regulate the synthesis and turnover of complex sphingolipids and the dynamics of the actin cytoskeleton (2008, NA)
• Schematic presentation of the roles of phospholipases A2 and their lipid products in monocyte chemotaxis to MCP-1 (2008, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Dictyostelium discoideum)
• CNX/CRT cycle (2008, NA)
• Schematic presentation of the signaling pathway induced by HCV core protein for insulin resistance in human hepatocytes (2008, NA)
• Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production (2008, Homo sapiens,Mus musculus)
• Extracellular arm of cAMP signalling pathway in skeletal muscle (2008, Rattus norvegicus,Homo sapiens)
• Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine (2008, NA)
• Canonical Wnt signaling pathway (2008, Homo sapiens,Mus musculus)
• Mapping Genetically Compensatory Pathways from Synthetic Lethal Interactions in Yeast (2008, Saccharomyces cerevisiae,Sorghum bicolor,Homo sapiens)
• MAP kinase pathway analysis of the meta-modes (2008, Homo sapiens,Candida dubliniensis)
• Permanent embryo arrest: molecular and cellular concepts (2008, Bos taurus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• Gene Network A (2008, NA)
• Gene Network B (2008, NA)
• Alternative models for selective Th1/Th2 induction by DCs (2008, Schistosoma mansoni,Nippostrongylus brasiliensis,Acanthocheilonema viteae,Homo sapiens,Mus musculus)
• F igure 1.— (2008, NA)
• Signal transduction events initiated by Kit and FcERI leading to specific mast cell responses, and the integration of these pathways for the synergistic enhancement of mast cell mediator release (2008, Homo sapiens)
• Caveolin-1 is a highly versatile regulator of cell signaling (2008, NA)
• Apoptosis signalling pathways (2008, NA)
• Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors (2008, NA)
• Uncovering Genes with Divergent mRNA-Protein Dynamics in Streptomyces coelicolor (2008, Streptomyces coelicolor)
• Inhibition of IGF-I signaling is involved in neuronal death after H2O2 (2008, NA)
• Sorting and transport within the biosynthetic and endo-lysosomal pathways (2008, NA)
• NOS/NO signaling pathways that regulate AJ and TJ dynamics in the testes (2008, NA)
• Summary of caspase 2-mediated signaling cascades in heat-induced germ cell apoptosis (2008, NA)
• Wnt signaling pathway and its inhibition by AB aggregates (2008, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Inter-individual mRNA expression variances in the transforming growth factor-beta (TGFB) signaling pathway in rheumatoid arthritis (RA) compared with normal control (NC) (2008, Mus musculus,Rattus norvegicus,Helicobacter pylori,Helicobacter pylori 35A,Homo sapiens,Mouse mammary tumor virus)
• Representation of the two NFKB signaling pathways (2008, NA)
• Arsenic-induced acquired androgen independence (2008, NA)
• Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice (2008, Homo sapiens,Mus musculus)
• The IL-4 and IL-13 receptor signaling pathways (2008, NA)
• Pathogenesis of prostate cancer: from molecular to metabolic alterations (2008, NA)
• Insulin/FoxO1, TGFB1/Smad, and TNFA/cJun signaling pathway crosstalk in coordinated regulation of bile acid synthesis in the cholestatic liver injury, fibrogenesis, and regeneration (2008, NA)
• General scheme of insulin signaling (2008, Mus musculus,Rattus norvegicus,Psammomys obesus,Homo sapiens)
• Adenylyl cyclase–cyclicAMP signaling system (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Time ordered sequential events control cellular decision of migration (2008, Homo sapiens,Mus musculus,Bos taurus,Diaporthe sclerotioides,unidentified)
• Proposed model for effects of agonists and antagonists on PKC activity that controls UGT activity (2008, NA)
• Determinate Root Growth and Meristem Maintenance in Angiosperms (2008, Magnoliopsida)
• Schematic overview of the integrin signaling (2008, Helicobacter pylori,Homo sapiens)
• Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer (2008, NA)
• Some cellular processes implicated in the pathogenesis of PAH (2008, Homo sapiens)
• The canonical Wnt/Beta-catenin signaling pathway (2008, NA)
• Cotargeting survival signaling pathways in cancer (2008, Homo sapiens)
• The pathways involved in polycystic kidney disease (2008, Homo sapiens,Rattus norvegicus)
• The activation of the Wnt/Beta-catenin pathway (2008, NA)
• Regulation of uPA expression in breast epithelial and cancer cells (2008, Homo sapiens)
• Mesenchymal stem cell dysfunction in HGPS (2008, NA)
• Comparison models summarizing how eIF4E is not only downstream of the PI3K–AKT pathway (left) but can modulate this PI3K–Akt axis through NBS1 (right) (2008, NA)
• Binding of specific signalling proteins to phosphorylated tyrosine residues on KIT following receptor activation and the subsequent signalling events leading to mast cell responses (2008, Homo sapiens)
• Key proteins regulated by PKB that are involved in metabolism (yellow); cell cycle progression (green); cellular growth (red); cell survival and apoptosis (blue); angiogenesis (orange) and neurological processes (purple) (2008, NA)
• Complex relationship between PI3-K, mTOR and PKB signalling (2008, NA)
• Classic renin-angiotensin-aldosterone system (RAAS) pathway and angiotensin II (Ang II)/insulin signaling in the vascular smooth muscle cell (2008, NA)
• Cellular responses after six hours exposure to L (2008, Lactiplantibacillus plantarum,Lacticaseibacillus rhamnosus GG,Limosilactobacillus fermentum,Lactiplantibacillus plantarum WCFS1,Alkalihalobacillus clausii,Lactiplantibacillus plantarum subsp. plantarum,Mus musculus,Cricetus cricetus,Homo sapiens,Candida dubliniensis)
• Signaling pathways involved in ET-1-induced c-jun expression (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Response to pathway inhibitors of tumor cells depends on the mechanism of pathway activation (2008, Homo sapiens,Mus musculus,Drosophila melanogaster,clinical samples)
• Somatic mutations affect key pathways in lung adenocarcinoma (2008, Homo sapiens,Nicotiana tabacum)
• Reduction of hydrogen peroxide mediated by thioredoxin (A) and glutathione (B) pathways (2008, NA)
• Inter-individual mRNA expression variances in the mitogen-activated protein kinase (MAPK) signaling pathway in rheumatoid arthritis (RA) compared with normal control (NC) (2008, Mus musculus,Rattus norvegicus,Helicobacter pylori,Helicobacter pylori 35A,Homo sapiens,Mouse mammary tumor virus)
• Genes up-regulated and down-regulated by FGF-2 in TGFB signaling pathway (2008, Homo sapiens)
• Signal transduction pathways activated by low-intensity pulsed ultrasound (2008, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Hippospongia communis)
• Proposed model of KSHV-induced lymphatic reprogramming of endothelial cells (2008, Homo sapiens,Human gammaherpesvirus 8,NA)
• Simplified scheme of TNFA signaling (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Petrocephalus catostoma)
• Just in time for late-LTP (2008, NA)
• Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System (2008, NA)
• Domoic Acid Toxicologic Pathology: A Review (2008, Pinna nobilis,Patinopecten sp.,Mytilus edulis,Emerita analoga,Siliqua patula,Portunus pelagicus,Panthera leo,Zalophus californianus,Balaenoptera musculus,Enhydra lutris nereis,Enhydra lutris,Gallus gallus,Danio rerio,Oncorhynchus kisutch,Triakis semifasciata,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Pseudo-nitzschia multiseries,Digenea simplex,Escherichia coli)
• This diagram shows the temporal control of F-actin polymerization and emphasizes the role of Ca2+ and related factors (2008, NA)
• Various TZDs on the PGE2 pathway (2008, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Putative protective mechanisms of ACE2 against Ang II-mediated impairment of insulin/Akt signalling pathway (2008, NA)
• Factors involved in the regulation of corporal smooth muscle tone (2008, Homo sapiens,Rattus norvegicus,Candida dubliniensis)
• Peroxisome proliferator-activated receptorG and ligands: pathways and functions (2008, Nicotiana tabacum,Candida dubliniensis,Olea europaea,Capsicum frutescens,Prunus dulcis,Calocedrus formosana,Mus musculus,Rattus norvegicus,Homo sapiens)
• Intracellular signaling activated through FGFRs (2008, NA)
• Molecules and pathways implicated in sulfur mustard (SM)-induced apoptosis (2008, Mus musculus,Oryctolagus cuniculus,Sus scrofa,Cavia porcellus,Corynebacterium phage gamma,unclassified bacterial viruses,Homo sapiens,Escherichia coli,Xenopus laevis,Human papillomavirus type 16)
• The IL-1 signaling pathway (2008, NA)
• Regulation of FGF signaling (2008, NA)
• IPA of the genes encompassed by the conserved 166 signatures and belonging to the Wnt signal transduction pathway (2008, NA)
• Modeling Cancer Progression via Pathway Dependencies (2008, Homo sapiens,Mus musculus)
• Integration of genomic and nongenomic/rapid ER signaling and its crosstalk with growth factor receptor and cell kinase pathways in endocrine resistance: a working model (2008, NA)
• Schematic diagram illustrating the canonical insulin signaling pathway (2008, NA)
• Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation (2008, NA)
• Schematic overview of the LPS TLR4 signaling pathway (2008, NA)
• Hypothetical pathway by which desflurane/hypoxia induces a vicious cycle of apoptosis and AB generation/aggregation (2008, NA)
• Following the cytokine signaling pathway to leukemogenesis: a chronology (2008, NA)
• Proposed mechanism by which CCL2 induces PC3 cell survival upon serum starvation (2008, NA)
• Interactions of KEGG pathways for differentially expressed genes in different stages of PAD (2008, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Over-representation of Toll-like receptor signaling pathway genes (2008, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Differentiation of Th17 cells and inducible TREG cells (2008, NA)
• Th1 Polarization Pathway (2008, NA)
• PRRs and their corresponding ligands (2008, NA)
• Canonical pathway analysis (2008, NA)
• Response of A549 cells exposed to crocidolite (2008, Bos taurus,Drosophila melanogaster,Oryctolagus cuniculus,Antarctothoa delta,Homo sapiens,Mus musculus,Glycine max)
• TNF provokes a cholesterol-insensitive processing of SREBP-1 (2008, Rattus norvegicus,Homo sapiens)
• Glutathionine (GSH) redox network (2008, NA)
• Metabolic pathways for the synthesis of phospholipids and neutral lipid classes in S (2008, Saccharomyces cerevisiae,Homo sapiens)
• Enzymatic reactions and assays (2008, Thermotoga maritima)
• Integration of redox signaling (2008, NA)
• Hypothetical ‘super pathway’ not stratified for cell type illustrating known direct interactions between the 892 PD priority genes (regulation, expression and promoter binding only) (2008, Homo sapiens,Mus musculus)
• Redox regulation of stress-responsive kinase (SAPK) signaling pathways (2008, NA)
• Redox regulation of the PI3K/Akt signaling pathway (2008, NA)
• GIP increases Bcl-2 transcription in pancreatic Beta cells (2008, NA)
• Tie2 (Tie2 tyrosine kinase receptor) structure and Ang-1-Tie2 signallingsignaling (2008, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 8,adeno-associated virus 2,Homo sapiens,Bos taurus,Staphylococcus aureus)
• Common polymorphisms in the genes associated with Alzheimer’s Disease (AD) (2008, NA)
• HSPs regulatory function in the intrinsic (A), extrinsic and caspase independent pathways to death (B) (2008, Drosophila melanogaster,Taenia solium,Taenia crassiceps,Mus musculus,Rattus norvegicus,Homo sapiens,Arabidopsis thaliana,Danio rerio,Human T-cell leukemia virus type I)
• Redox-sensitive steps in hypothetical redox signaling pathways (2008, NA)
• The signaling pathway active in BxPC3 cells from collagen I outside the cell to induction of cell scattering and up-regulation of N-cadherin (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus)
• PI 3-kinase/AKT-dependent pathways involved in IL-1 induction of IL-6 (2008, NA)
• Pathogen recognition systems (2008, NA)
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways (2008, NA)
• Ingenuity Pathway Analysis (IPA) of genes specifically overexpressed in B1-Arg389 transgenic mouse hearts (2008, Homo sapiens,Mus musculus)
• Pathways for major lipid metabolism (2008, NA)
• Autophagy fights disease through cellular self-digestion (2008, NA)
• Glycolysis pathway (2008, NA)
• Alterations in extraceullular matrix and secreted proteins associated with metastatic cancer (2008, NA)
• Pathway representation of all the tryptophan related genes analyzed (2008, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Hypericum perforatum,Homo sapiens,Danio rerio,Mouse mammary tumor virus)
• Alterations in adhesion-mediated signaling and cytoskeleton remodeling in metastatic cancer (2008, NA)
• NFKB canonical signaling pathway from IPA (2008, NA)
• DHA, NPD1, and BAPP-derived AB peptide signaling circuits in homeostatic aging and in AD (2008, NA)
• (Left panel) In unstretched myocytes, Shp2 associates with and dephosphorylates FAK, inhibiting FAK activity (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Elephas maximus)
• Pathway Studio diagram of common regulators of differentially expressed genes (2008, Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Moloney murine leukemia virus)
• EGF signaling pathway generated by the Ingenuity Pathway Analysis (IPA) software (2008, NA)
• The involvement of death receptor pathway (right half) and mitochondrial pathway mediated (left half) apoptosis in nurse cell formation (2008, Trichinella spiralis,Homo sapiens)
• The role of the MAPKKKA/MEKK1–MKK4/MKK5–MPK3/MPK6 cascade in regulating camalexin biosynthesis in plants challenged by pathogens (2008, NA)
• Regulatory networks sensitive to tyrosine kinase inhibitors in H3255 and MKN45 cells revealed by PhosphpScan-SILAC study (2008, NA)
• Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2 (2008, NA)
• TRAF6- and MEKK1-mediated signal for IFNB production in the RLH/IPS-1 signaling pathway (2008, NA)
• Serotonin is synthesized in the pulmonary arterial endothelial cells by tryptophan hydroxylase1 (Tph1) (2008, Homo sapiens)
• The role of the AMPK-GSK3Beta-CREB signaling pathway in gluconeogenesis (2008, NA)
• The Ras signaling pathway (2008, NA)
• Transforming growth factor-beta (TGFB) signaling pathway (2008, NA)
• Regulation of sodium transport by PAR2 in the rat cTAL (2008, Rattus norvegicus,Homo sapiens)
• The erbB family and the IGF/IGF-1R system (2008, NA)
• MiRNA model for the molecular pathogenesis of recurrent ovarian cancer (2008, Homo sapiens,Mus musculus,Caenorhabditis elegans,clinical samples)
• Current concepts of the amino acid signaling pathway leading to protein synthesis (2008, Sus scrofa,Homo sapiens)
• Platelets, Petechiae, and Preservation of the Vascular Wall (2008, NA)
• IGF-I signaling pathway in nurse cell formation (2008, Trichinella spiralis,Homo sapiens)
• Working model for Eph receptor function in tumor promotion and tumor suppression (2008, NA)
• D2 receptors and group I mGluRs to induce I-LTD in dopamine neurons (2008, Mus musculus,Rattus norvegicus,Xenopus laevis,Triportheus paranensis,Homo sapiens)
• Complement pathway altered in disease (2008, NA)
• Mitochondrial regulation of the apoptotic pathway is altered in disease and modulated by sirolimus treatment (2008, NA)
• Potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle (2008, NA)
• Biosynthetic relationships between amino acids, as defined by their biosyntheses and their relationships with the glycolytic pathway and the citric acid cycle (2008, NA)
• Mechanisms for age-associated up-regulation of PGE2 production and its interruption by vitamin E in Mφ (2008, Mus musculus,Homo sapiens)
• From the extracellular matrix to HIF and from HIF to the extracellular matrix (2008, NA)
• From nutrients to HIF and from HIF to metabolism (2008, NA)
• From oxygen to HIF and from HIF to oxygen (2008, NA)
• CC family chemokines directly regulate myoblast responses to skeletal muscle injury (2008, Mus musculus,Homo sapiens)
• Signaling pathway for the regulation of actin polymerization in smooth muscle (2008, NA)
• Proposed model of ICAM-1-mediated changes in Ps in microvasculature (2008, Mus musculus,Homo sapiens)
• Interdependent roles for hypoxia inducible factor and nuclear factorKB in hypoxic inflammation (2008, NA)
• Fermentative pathway in T (2008, NA)
• EGFR-MAPK pathway model (2008, NA)
• Glycerol biosynthesis and other major pathways contributing to cytosolic NAD+/NADH balance in S (2008, Saccharomyces cerevisiae,Homo sapiens)
• Regulation of smooth muscle cell contraction (2008, Homo sapiens,Rattus norvegicus)
• Top network of upregulated genes in quadriceps muscles of COPD patients, compared with control subjects (2008, NA)
• Working model for the interaction of AR and Wnt/Beta-Catenin signaling pathway in castration-resistant prostate cancer cells (2008, NA)
• Predicted targets of miR-100 and miR-101 in the 3′-UTR of members of the mTOR pathway (2008, NA)
• Signal transduction pathway elicited by Env interaction with CCR5 required for Rac-1 activation and membrane fusion (2008, NA)
• Insights into the Roles of Gut Microbes in Obesity (2008, NA)
• Cross talk between cAMP/PKA and MAPK1,2 downstream of atRA signaling in HIV-infected podocytes (2008, Human immunodeficiency virus 1,Human immunodeficiency virus,Mus musculus,Homo sapiens)
• NHERF1 inhibition of PTH-stimulated ERK1/2 activity (2008, NA)
• Pathways of global genome nuclear excision repair (GG-NER) and transcription-coupled nuclear excision repair (TC-NER) (2008, NA)
• Migration of Airway Smooth Muscle Cells (2008, NA)
• Calcium Signaling in Airway Smooth Muscle (2008, NA)
• Airway Smooth Muscle Cell as an Inflammatory Cell (2008, NA)
• Activation of the transcription factors IRF3 and NFKB in response to infection with a single-stranded RNA virus (2008, Homo sapiens,Vasconcellea candicans,Aurantiochytrium single-stranded RNA virus 01,NA)
• RGS protein Crg2 links the mating and cAMP signal transduction pathways in C (2008, Cryptococcus neoformans,Homo sapiens)
• Intrafollicular predictors and regulators of oocyte quality within the oocyte–somatic cell regulatory loop (2008, NA)
• Networks among genes involved in milk fat synthesis (2008, Saccharomyces cerevisiae,Zea mays,Candida dubliniensis,Sorghum bicolor,Sequoia sempervirens,Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Erebia epipsodea)
• Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure (2008, NA)
• Proposed effects of calcitonin and MAP kinase pathways on CD44 expression in androgen-independent prostate cancer (2008, Bos taurus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Putative gene function in ascorbate homeostasis and Al tolerance (2008, NA)
• Apoptosis pathways: The extrinsic or death receptor pathway (left) is triggered by members of the death receptor superfamily such as Fas (2008, NA)
• Integration of Global Signaling Pathways, cAMP-PKA, MAPK and TOR in the Regulation of FLO11 (2008, Saccharomyces cerevisiae,Candida albicans,Saccharomyces cerevisiae Sigma1278b,Aphyosemion alpha,Homo sapiens)
• Prostaglandin E2 Inhibits Specific Lung Fibroblast Functions via Selective Actions of PKA and Epac-1 (2008, NA)
• Inhibition of each signaling molecules by natural products in insulin signaling (2008, Saccharomyces cerevisiae,Arabidopsis thaliana,PX clade,Schizosaccharomyces pombe,Talaromyces wortmannii,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Corynebacterium phage gamma,uncultured cyanobacterium,Halichondria okadai)
• Proposed mechanism of the IL-1Beta-induced signalling pathway involved in the synthesis of IL-6 in primary cortical neurones (2008, Mus musculus,Homo sapiens)
• DSB repair pathways (2008, NA)
• Possible mechanisms of ethylene-GA crosstalk revealed by the analysis of the gai eto2-1 double mutant (2008, NA)
• Chitin signaling pathway vs (2008, NA)
• Building bone to reverse osteoporosis and repair fractures (2008, NA)
• Schematic diagrams depicting the Wnt signaling pathways (2008, NA)
• Simplified schemes of the three Wnt signaling cascades (2008, Mus musculus,Homo sapiens)
• Three Wnt signaling pathways (modified from Huelsken and Behrens, 2002) (2008, NA)
• Upstream regulators and downstream targets of Beta-catenin during embryonic liver development (2008, NA)
• Embryonic liver development (2008, NA)
• Uncovering cryptic genetic variation in C (2008, Caenorhabditis elegans,Homo sapiens)
• Hypothetical mechanism whereby FRNK inhibits TGF-Beta-induced Alpha-SMA expression in the presence and absence of FAK (2008, NA)
• Functional Interactions of NG2 (2008, Homo sapiens)
• In the canonical TGFB signalling pathway, ligands signal through type I and II transmembrane protein kinase receptors (2008, NA)
• Signalling pathways mediated by vGPCR (2008, NA)
• Cell cycle pathways in S (2008, NA)
• JAK/STAT pathway regulators (2008, NA)
• Hypothalamic Malonyl-Coenzyme A and the Control of Energy Balance (2008, Mus musculus,Homo sapiens)
• ECM-receptor interaction pathway enriched by human switch-like genes (2008, Homo sapiens,Mus musculus,Candida dubliniensis)
• Molecular processes that handle — and mishandle — dietary lipids (2008, NA)
• Metabolic model used for the determination of intracellular fluxes (2008, NA)
• Molecular Mechanisms in COPD pathogenesis and potential therapeutic targets (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Molva molva)
• Growth hormone-mediated JAK/STAT signal transduction (2008, NA)
• Differentiation of vulE vs (2008, Caenorhabditis elegans,Homo sapiens)
• Inflammation Joins the “Niche” (2008, NA)
• Ingenuity pathway analysis on AP-1 related gene network (2008, NA)
• Biological network representing the bipolar disorder p-value ranking (2008, NA)
• Biological network representing the schizophrenia p-value ranking (2008, NA)
• Ingenuity pathway analysis on NFKB related gene network (2008, NA)
• Signaling Flux Redistribution at Toll-Like Receptor Pathway Junctions (2008, NA)
• Ras signaling pathway influences the outcome of oncolytic virus G207 insult in MPNST cells (2008, Mus musculus,Human alphaherpesvirus 1,Homo sapiens)
• Multiple feedback loops of p53 pathway (2008, NA)
• Bimodal genes that were switched "on" as a result of HIV infection in KEGG T-cell receptor signalling pathways (2008, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus,bacterium 1-2B,NA)
• Arc function in mGluR-LTD (2008, Mus musculus,Rattus norvegicus,Homo sapiens,catfish)
• Signal transduction pathway in the UPR (2008, Saccharomyces cerevisiae,Aspergillus niger,Komagataella pastoris,Aspergillus awamori,Homo sapiens,Cricetulus griseus,Trichoplusia ni)
• PARP-1 in NFAT signaling pathway (2008, NA)
• Working model for the differential regulation of the SNAT2 gene in HepG2 cells during activation of the AAR or UPR pathways (2008, NA)
• Gonadotropin-mediated steroidogenesis in Leydig cells (2008, Mus musculus,Homo sapiens)
• Regulation of IK and IK1 by MAPKs and PI3K in sham and hypertrophied cardiomyocytes (2008, Rattus norvegicus,Homo sapiens)
• Genes that contain the 100 most differentially methylated CpG sites between normal and lung cancer tissue samples (p-value < 0.005) (2008, Homo sapiens,Mus musculus)
• Simplified schematic drawing of the TGF-Beta-Smad pathway (2008, Homo sapiens,Mus musculus)
• IGFs in the peripheral nervous system (2008, NA)
• Hypothetical pathway for B2AR-mediated antiapoptotic effect in H9c2 cardiomyocytes (2008, Rattus norvegicus,Homo sapiens)
• A, Classical ER membrane-associated and nuclear-associated signaling (2008, Cavia porcellus,Homo sapiens)
• Presentation of asbestos-induced effects (2008, NA)
• Cellular model of song-regulated synapsin expression in NCM, depicting direct and indirect pathways of synapsin regulation (2008, Gallus gallus,Carassius auratus,Serinus canaria,Taeniopygia guttata,Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus,Pteropus alecto retrovirus)
• Model of HOG signaling pathway response during the long-term hypersaline adaptation in the extremely halophilic H (2008, NA)
• New model for neural induction in Xenopus laevis embryos (2008, NA)
• Classical view of three independent Wnt signalling pathways (2008, NA)
• TFPI anti-coagulant and anti-inflammatory activities (2008, Homo sapiens,Papio hamadryas,Rattus norvegicus,Escherichia coli)
• Use of MIMO models to infer regulatory interactions in breast cancer cells (2008, NA)
• PPARs are mediators of lipid signaling in inflammation and cancer (2008, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Helicobacter pylori,Curcuma longa)
• Schematic view of the Vav family-regulated signaling pathways of DT40 B-cells (2008, Gallus gallus,Homo sapiens)
• Signalling pathways involved in the induction of astrocyte specification/differentiation (2008, NA)
• Olig2 and the transcription factor network controlling motor neuron differentiation (2008, NA)
• Tight regulation of MUC5AC mucin induction by pneumolysin via PAK4-JNK and MKP1 signaling pathways (2008, NA)
• Genes with differential expression in the carcinoma and papillary adenocarcinoma tumors were assembled into distinct metabolic pathways (2008, NA)
• Progressive changes in progenitor cells during motor neuron development (2008, NA)
• Working models for how c-di-GMP influences flagellar function (2008, NA)
• Putative biochemical pathways involving MGAT3 (2008, Mus musculus,Rattus norvegicus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Curcuma longa)
• Higher expression of genes involved in O-glycan synthesis in the carcinoma compared to the papillary adenocarcinoma tumors (2008, NA)
• Merger of the interaction maps for the three human proteins ING1, MEKK, and p38a (p38MAPK) based on empirical data retrieved from the STRING database (2008, NA)
• Hierarchical layout of the B-cell receptor pathway downloaded from the HPRD pathway database (2008, Homo sapiens)
• Hierarchical layout of the EGFR1 pathway downloaded from the HPRD pathway database (2008, Homo sapiens)
• Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data (2008, NA)
• Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data (2008, NA)
• Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells (2008, NA)
• Pathway schematic of significantly regulated genes in (A) NFKB signalling and (B) MAP kinase signalling (2008, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human immunodeficiency virus 1)
• Neuronal pathway containing proteins found in Lewy bodies (2008, Homo sapiens,Mus musculus)
• Signal transduction pathways in the airway epithelia (2008, Pseudomonas aeruginosa,Pectobacterium carotovorum,Homo sapiens,Drosophila melanogaster)
• Interactions of known PD genes (marked yellow) with the priority genes of this study (2008, Homo sapiens,Mus musculus)
• Candidate interactors and their putative postion in the Frizzled signaling pathway (2008, Escherichia coli,Escherichia coli BL21,Escherichia coli str. K-12 substr. DH10B,Drosophila melanogaster,Caenorhabditis elegans,vectors,unidentified shuttle vector,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Xenopus laevis,Mouse mammary tumor virus)
• Schematic view of part of the IGF-1 and integrin signaling pathway genes transcribed by hNCC (2008, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Amniota,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Schematic model depicting the potential preventative effects of RA against AP-1–dependent activation of COX-2 expression (2008, NA)
• Metabolic scheme (2008, Homo sapiens,Rattus norvegicus,Bos taurus,Oryza sativa)
• Essence of retrograde signaling in model organisms (2008, NA)
• T Cell Receiptor Signaling Pathway (2008, NA)
• Role of Gut-Lymph Factors in the Induction of Burn-Induced and Trauma-Shock-Induced Acute Heart Failure (2008, NA)
• MAPK Signaling Pathway (2008, NA)
• NCAM upregulation leads to a functional switch (2008, Mus musculus,Homo sapiens)
• Structures and abbreviated names for metabolites in the D2HN melanin biosynthetic pathway and related shunt pathways in W (2008, NA)
• Gene expression and metabolite levels in the distal network pathways related to Met- and Trp-derived GS biosynthesis (2008, NA)
• JAK/STAT signaling pathway and SARS-CoV (2008, NA)
• Epithelial barrier function by lactobacilli (2008, Homo sapiens)
• Network of differentially expressed genes in the cell cycle control pathway in sorted R1/R2 Eklf−/− E13.5 fetal liver cells (2008, Mus musculus,Homo sapiens)
• AKT reduces the growth-inhibitory function of TGFB1 (2008, NA)
• Proposed model for SHC-1 function in the KGB-1 JNK signaling pathway (2008, NA)
• General regulatory mechanism of the HOG signaling pathway in fungi (2008, NA)
• Controlled AQP2 transcription in collecting duct principal cells (2008, Rattus norvegicus,Homo sapiens)
• Unexpected pieces to the senescence puzzle (2008, NA)
• Gene expression data mapped on the mouse insulin signaling pathway (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Signalling pathways underlying neuronal survival and cognitive performance (2008, NA)
• Relationship between EphB2, FGFR, MAPK, and cell repulsion (2008, NA)
• Scheme summarises different intracellular pathways during osteoblast differentiation which include promoting (blue) and inhibiting (red) factors and are mainly mediated by Smad proteins (2008, Homo sapiens,Rattus norvegicus,Cricetus cricetus,Mandrillus leucophaeus,Diaporthe sclerotioides,Dipturus trachyderma)
• TLR signalling pathways (2008, Homo sapiens,Mus musculus)
• Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2−/− Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM (2008, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Phospholipid metabolism in S (2008, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Proposed pathway for metabolic activation and detoxication of aristolochic acid I (AAI), leading to renal injury and urothelial cancer (2008, NA)
• Proposed functions of hBVR in the MAPK-signaling pathway (2008, Homo sapiens,Cervus elaphus)
• Cross talk between PKA, PI3K/AKT and WNT/CTNNB1 intracellular signaling pathways (2008, Homo sapiens,Mus musculus,Equus caballus)
• The role of the IGF-1/phosphatidylinositol 3-kinase (PI3K)/Akt pathway and atrogin-1 and MuRF-1 in SI-induced atrophy and in the amelioration of atrophy by high-load isometric contractions (2008, Rattus norvegicus,Homo sapiens)
• Beta-Adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel (2008, NA)
• Schematic diagram showing the pathway involved in high glucose- and high insulin-induced extracellular matrix protein synthesis mediated by GSK3B and eIF2BE (2008, Mus musculus,Homo sapiens)
• HER receptors and their ligands (2008, Homo sapiens,Mus musculus)
• Behavioural gene programming (2008, Mus musculus,Rattus norvegicus,Glycine max,Triticum aestivum,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• Possible model for CCL5-mediated mRNA translation in CD4+ T cells (2008, NA)
• The mechanism of retinoic acid stimulation of NIS expression by modifying signal transduction pathways in breast cancer and thyroid cells, based on the results of the inhibitor studies (2008, Homo sapiens,Rattus norvegicus)
• The NFKB signalling pathway (isoforms of IKBA not shown) (2008, Mus musculus,Reptalus panzeri,Homo sapiens)
• IRF-5 in the innate antiviral response (2008, Homo sapiens,Mus musculus)
• Oxidative and alkylation DNA damage is effectively repaired by the DNA BER pathway (2008, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Danio rerio,Cerobasis alpha)
• Schematic summarizing CRF and glucocorticoid effects on the Beta-adrenoceptor–cAMP signaling pathway in the basolateral amygdala in influencing memory consolidation (2008, Rattus norvegicus,Homo sapiens)
• Autocrine/paracrine induction of osteogenesis in hMSCs by PKA signaling (2008, NA)
• An E2F1-Dependent Gene Expression Program That Determines the Balance Between Proliferation and Cell Death (2008, Rattus norvegicus,Homo sapiens)
• ERK1 and ERK2 knockdown differently affect signals involved in patterning of the early embryo (2008, NA)
• Analysis of Nodal signaling processes in ERK1MO and ERK2MO gene expression profiles (2008, NA)
• Analysis of FGF signaling processes in ERK1MO and ERK2MO gene expression profiles (2008, NA)
• Analysis of Wnt signaling processes in ERK1MO and ERK2MO gene expression profiles (2008, NA)
• Analysis of BMP signaling processes in ERK1MO and ERK2MO gene expression profiles (2008, NA)
• MCF10A Pathway 2 affected by TFIIS knockdown (2008, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Sequoia sempervirens,Agaricus bisporus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Bos taurus,Celithemis elisa,Expression vector pCMV6)
• Major pathways affected by TFIIS knockdown in MCF7 (2008, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Sequoia sempervirens,Agaricus bisporus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Bos taurus,Celithemis elisa,Expression vector pCMV6)
• Furin action in pituitary gonadotrope cells (2008, Mus musculus,Homo sapiens)
• COMPLEMENT ACTIVATION FRAGMENT Bb IN EARLY PREGNANCY AND SPONTANEOUS PRETERM BIRTH (2008, Oryctolagus cuniculus,Capra hircus,Metamycoplasma hominis,Ureaplasma urealyticum,Homo sapiens,Nicotiana tabacum)
• Mutations of GM-CSFRA disrupt alveolar macrophage functions and surfactant homeostasis (2008, Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus sp. group B,Homo sapiens,Mus musculus,Pneumocystis jirovecii)
• MCF10A Pathway 1 affected by TFIIS knockdown (2008, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Sequoia sempervirens,Agaricus bisporus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Bos taurus,Celithemis elisa,Expression vector pCMV6)
• Schematic representation of GADS-related signaling in T cells (2008, Dipturus trachyderma,Homo sapiens)
• Systems Analysis Unfolds the Relationship between the Phosphoketolase Pathway and Growth in Aspergillus nidulans (2008, Aspergillus nidulans)
• Overindulgence and metabolic syndrome: is FoxO1 a missing link? (2008, NA)
• Function of the PI3K/AKT/mTOR signalling in cancer (2008, Homo sapiens,Mus musculus)
• Citrate cycle genes are up-regulated in the brains of nurse bees (2008, Drosophila melanogaster,Apis mellifera,Homo sapiens)
• Aged Retinal Pigment Epithelium/Choroid: A Potential Substratum for the Pathogenesis of Age-Related Macular Degeneration (2008, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• RhoA GTPase modulation of the paracellular pathway for fluid flux (2008, NA)
• PIM/LAM biosynthetic pathway (2008, Mycobacterium tuberculosis,Mycolicibacterium smegmatis,Homo sapiens)
• Predicted pathways of propionate metabolism in M (2008, NA)
• PPARA and AMPK activities in the cancer cells exposed to energetic stress (2008, NA)
• Effector pathways for PPARG in NSCLC (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Proposed ET-1 signaling through BPix/p66Shc/FOXO3a complex in glomerular mesangial cells (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• PharmGKB Irinotecan Pathway (2008, Homo sapiens)
• Gremlin Enhances the Determined Path to Cardiomyogenesis (2008, NA)
• Neuroendocrine control of pituitary and gonadal function (2008, Oryctolagus cuniculus,Ovis aries,Paraechinus aethiopicus,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Gallus gallus)
• Interactions between signalling modules (2008, NA)
• Description of possible involved signalling pathways (2008, NA)
• Microvasculature in the pathogenesis of inflammatory bowel disease (2008, NA)
• Glucose transport regulation by the Akt/TSC pathway (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Stimulus Design for Model Selection and Validation in Cell Signaling (2008, NA)
• RXRA phosphorylation in HCC cells (2008, NA)
• Cellular mechanisms of estrogen-Induced vascular relaxation and remodeling (2008, NA)
• NO activates sGC, and produced cGMP regulates PKG, PDE2, PDE3, and/or protein phosphatase (PPase) (2008, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus,Panax ginseng)
• Proposed estradiol (E2) actions on hypothalamic cells (2008, NA)
• Deciphering the Ubiquitin-Mediated Pathway in Apicomplexan Parasites: A Potential Strategy to Interfere with Parasite Virulence (2008, Drosophila melanogaster,Caenorhabditis elegans,Plasmodium falciparum,Toxoplasma gondii,Leishmania major,Plasmodium berghei,Plasmodium vivax,Cryptosporidium parvum,Plasmodium yoelii,Plasmodium chabaudi,Cryptosporidium hominis,Plasmodium yoelii yoelii,Saccharomyces cerevisiae,Escherichia coli,Arabidopsis thaliana,Solanum lycopersicum,Schizosaccharomyces pombe,Salmonella enterica,Agrobacterium tumefaciens,Pseudomonas syringae,Escherichia coli 27A,Dracophyllum minimum,Human immunodeficiency virus 1,Human papillomavirus,Homo sapiens,Mus musculus)
• In silico knockout of PLCG1 in the HGF stimulated signalling network (2008, NA)
• Genes up-regulated and down-regulated by FGF-2 in IGF-I signaling pathway (2008, Homo sapiens)
• Control of EC gene expression by VEGF signaling to HDAC7 (2008, NA)
• Interferon signaling (2008, NA)
• Interrelationship of energy metabolism and insulin action in skeletal muscle (2008, NA)
• Wnt signaling pathways in INS-1 cells (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Diagrammatic representation of pathways associated with aroma production and links to associated metabolic activities (2008, Saccharomyces cerevisiae,Malus domestica,Pyrus communis,Musa acuminata,Ananas comosus,Saccharomyces cerevisiae EC1118,Rattus norvegicus,Homo sapiens)
• Refractory period in NFKB signaling (2008, NA)
• Proposed model for the effects of hypoxia-induced energy stress on them TOR pathway in HNSCC cells (2008, Homo sapiens)
• Activation of the UPR in the absence of H6PD (2008, Mus musculus,Homo sapiens)
• Inhibition of neurogenesis and axis duplication by mkrn2 via PI3K/Akt signaling pathway (2008, NA)
• Cdc1p function and the link between Cdc1p and Golgi inheritance (2008, NA)
• IGF-I-induced activation of PI 3-kinase/AKT and MAPK pathways in VSMCs (2008, NA)
• Musashi1 signaling in mammary progenitor cell proliferation (2008, NA)
• Genomic and nongenomic E2 signaling (2008, NA)
• The PKD1/class II HDAC/MEF2 signaling pathway in skeletal muscle (2008, Mus musculus,Homo sapiens)
• The role of cAMP-stimulated adipogenesis via PKA- end Epac1-dependent processes (2008, NA)
• Wnt Moves Beyond the Canon (2008, NA)
• Chemical Rescue of ΔF508-CFTR Mimics Genetic Repair in Cystic Fibrosis Bronchial Epithelial Cells (2008, Adeno-associated virus)
• Induction and lifetimes of signal transduction proteins (and their mRNAs) at various positions in signal transduction networks (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Feedback loops in NFKB signaling (2008, NA)
• Comparison of pathway analysis on the data set using the MBCB, RMA or RAW background corrections (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Summary of GRTH impact in apoptotic pathways in germ cells (2008, NA)
• Organelles in Blastocystis that Blur the Distinction between Mitochondria and Hydrogenosomes (2008, NA)
• Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Resistance to ErbB-targeted cancer therapeutics (2008, NA)
• Microarray data for the genes in the pathway coined from the central genes in the KEGG pathways ‘insulin signaling pathway’ and ‘adipocytokine signaling pathway’ (2008, NA)
• Activity-dependent gene expression in neurons (2008, Rattus norvegicus,Homo sapiens)
• Chromosomal passenger complex generates an alternative APC/C inhibitory signal that amplifies the 'wait anaphase' signal from unattached kinetochores (2008, NA)
• Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice (2008, Mus musculus,Homo sapiens)
• HIV-1 Activates Macrophages Independent of Toll-Like Receptors (2008, NA)
• HCMV regulates the expression of multiple components of the NFKB signaling pathway (see Table and Table S1 in the supplemental material for abbreviations) (2008, Human betaherpesvirus 5)
• Role of CREB and ICER in the regulation of GABRA1 expression (2008, NA)
• T-cell polarizing factors (2008, NA)
• Several signaling pathways work together in the TGFB1-induced expression of CCN2/CTGF in primary human gingival fibroblasts (2008, Homo sapiens)
• Immunosuppression in islet transplantation (2008, NA)
• Complement system and complement regulatory proteins (CRegs) (2008, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Lareunionomyces loeiensis,Sugarcane Ramu stunt disease phytoplasma)
• Actions of IGF-1 and angiotensin II in skeletal muscle (2008, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified,Scophthalmus rhombus,Allium motor)
• Potentiation of Nerve Growth Factor-Induced Neurite Outgrowth by Fluvoxamine: Role of Sigma-1 Receptors, IP3 Receptors and Cellular Signaling Pathways (2008, NA)
• Proposed mechanisms of HDACi-induced apoptosis in colon cancer cells involving the mitochondrial pathway (2008, NA)
• HIV-1 Activates Macrophages Independent of Toll-Like Receptors (2008, NA)
• Nitric oxide-peroxynitrite-PARP pathway in health and disease (2008, Homo sapiens)
• Ingenuity pathway analysis (2008, Homo sapiens)
• Interaction network and subcellular localization of differentially regulated genes by dasatinib in K562 cells (2008, NA)
• Exogenous/endogenous, regulators/modulators of PARP activity (2008, Homo sapiens)
• Prostaglandin synthesis pathway (2008, NA)
• TCR signaling pathway (2008, NA)
• A logic-based diagram of signalling pathways central to macrophage activation (2008, NA)
• Induction of immune response to Wolbachia infection in S2 cells (2008, NA)
• Modeling Cancer Progression via Pathway Dependencies (2008, Homo sapiens,Mus musculus)
• Leptin's roles in the endocardial cushion (2008, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Composite list of expressed genes and enriched transcription factors implicates specific regulatory networks (2008, NA)
• Positive and negative effects of GPC3 on cell signaling (2008, Drosophila melanogaster,Paracentrotus lividus,Strongylocentrotus purpuratus,Nematostella vectensis,Deuterostomia,Eumetazoa,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens)
• Receptors that sense danger signals released from neighboring injured retinal pigment epithelial (RPE) cells (2008, NA)
• Roles of IL-6-gp130 Signaling in Vascular Inflammation (2008, NA)
• Roles of IL-6-gp130 Signaling in Vascular Inflammation (2008, NA)
• Canonical and non-canonical Wnt signaling pathways (2008, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Cavia porcellus,Homo sapiens,Drosophila melanogaster)
• The regulation of the insulin signaling pathway by miRNA cluster mmu–mir-183–96–182 (2008, NA)
• Indirect (classical) and direct (novel) mechanisms of PIP2 action on BK channel currents (2008, Bos taurus,Canis lupus familiaris,Ovis aries,Rattus norvegicus,Diaporthe sclerotioides,Xenopus laevis,Homo sapiens)
• Alcohol metabolism and alcohol metabolites are to a large extent responsible for toxicity of alcohols (ethanol (EtOH), methanol and ethylene glycol) (2008, NA)
• Classical neurotransmitters of clozapine neighborhood in A auto-layout format and B a gamut of multifunctional molecules identified by IPA core and functional analyses (see table 2) (2008, NA)
• Regulation of Wnt/-catenin signalling pathway.(A) Wnt forms a ternary complex with Fz and Lrp5/6, which promotes stabilization of Beta-catenin, thereby activating the pathway (2008, NA)
• Unfolded protein response in mammalian cells (2008, Human immunodeficiency virus 1,Human betaherpesvirus 5,Homo sapiens,Mus musculus,NA)
• Mechanistic model to the action of H2O2 and TSA in oxidative-damaged HCT116 p53+/+ colorectal cancer cells (2008, NA)
• Metabolic network of oryza sativa L (2008, NA)
• Superposition of 'omics' data on maps (2008, Homo sapiens,Iris germanica)
• Anticancer therapy: boosting the bang of Bim (2008, NA)
• TLR3 signaling pathways (2008, NA)
• The Role of PPARG and Its Interaction with COX-2 in Pancreatic Cancer (2008, NA)
• Membrane VEGF receptors expressed by astroglial tumour cells (2008, NA)
• Estrogen receptors genomic pathway (2008, NA)
• Simplified scheme of the role of M1 macrophages in inflammation-driven carcinogenesis and the potential anticarcinogenic effect of PPAR ligands (2008, NA)
• Connections between the SAM cycle, transsulfuration pathway, and glutathione production (2008, Homo sapiens)
• Sub-Cellular and Signaling Mechanisms Underlying Polar PIN Localization.A model of regulators and pathways contributing to polar PIN localization in roots is proposed based on results discussed in this review (2008, NA)
• Manual layout of Type II interferon signalling (IFNG) taken from the integrated pathway diagram (Figure 2) (2008, NA)
• TGFB signaling pathway (2008, NA)
• Role of Plc1p in PKA regulation and expression of Msn2p-dependent genes (2008, Saccharomyces cerevisiae,Homo sapiens)
• Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs? (2008, NA)
• Schematic model illustrating constitutive vs (2008, NA)
• Mechanistic model for the cytoprotective effect of HIV-1 infection and Tat expression (2008, NA)
• Integrative Genome-Wide Expression Analysis Bears Evidence of Estrogen Receptor-Independent Transcription in Heregulin-Stimulated MCF-7 Cells (2008, Homo sapiens,Mus musculus,Bos taurus)
• Interaction between TKIs and BCRP (2008, NA)
• RNA Interference Screen Identifies Abl Kinase and PDGFR Signaling in Chlamydia trachomatis Entry (2008, NA)
• Apoptosis map (2008, Mus musculus,Homo sapiens)
• The RAS signaling pathway (2008, NA)
• Apoptotic signaling pathways after ligation of Fas/CD95 in type I and type II cells and the levels of interference by T (2008, Toxoplasma gondii,Homo sapiens)
• The relationship between hyperglycemia, iAng II, and pathological effects (2008, Mus musculus,Rattus norvegicus,Cricetulus griseus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana)
• Schematic mechanism of AB oligomer-mediated aberrant PAK activation and translocation in Alzheimer disease pathogenesis (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Natriuretic peptide C receptor signalling in the heart and vasculature (2008, NA)
• The possible contributions of JAK1, 2/STAT3 signaling pathway in CRC development (2008, NA)
• Ciliary functions of cystoproteins: mechanosensation and cell cycle control (2008, NA)
• From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy (2008, NA)
• Gene expression changes detected in selected pathways in M group (2008, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Rattus norvegicus,Bos taurus,Arabidopsis thaliana)
• Dual role of IL-6 in modulating insulin sensitivity in skeletal muscle (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Siproeta stelenes)
• BL module: A network visualization of the top 25 scoring genes in BL (2008, Homo sapiens,Saccharomyces cerevisiae)
• Reactions of peroxynitrite leading to either apoptotic or necrotic cell death (2008, NA)
• ER stress and ROS in NAFLD/NASH (2008, NA)
• Role of glycoprotein 130 (gp130) downstream signalling in the heart (2008, NA)
• TNF-induced and ROS-dependent events in target cells: the role of JNK activation in mediating cell death (2008, NA)
• Model depicting signaling pathways for TPR-mediated modulation of OLG development and function (2008, Rattus norvegicus,Homo sapiens)
• Glycolytic pathway and principal branches (2008, NA)
• S1P2 up-regulation impairs the activation of integrin AvB3, chemotactic, wound-healing, and morphogenetic responses in senescent ECs (2008, NA)
• Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer (2008, NA)
• Mutations in the glycoprotein 130 (gp130) receptor lead to an imbalance in downstream signalling pathways (2008, NA)
• Diagram of a PI3 kinase–aPKC signaling pathway mediating Wnt attraction in axon guidance (2008, Mus musculus,Chlorocebus aethiops,Homo sapiens)
• The proposed p75NTR- and GIRK channel-mediated cell death signaling pathway (2008, NA)
• Increased sensitivity of mutant huntingtin striatal cells to glutamate and dopamine receptor activation involves enhanced Cdk5 activity (2008, Homo sapiens,Mus musculus)
• Proposed model of IL-18-mediated microglia/astrocyte interaction in the spinal cord (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• Muscle growth: no IGFs, ands, or buts (2008, NA)
• Bimodal genes highlighted in KEGG ECM-receptor interaction diagram (2008, NA)
• Signalling pathways leading to the phosphorylation and inhibition of glycogen synthase kinase 3 (GSK3) (2008, NA)
• Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner (2008, NA)
• Regulation of the transcriptional co-regulator Beta-catenin (2008, NA)
• Relevant aspects of phosphoinositide metabolism (2008, NA)
• Types of Beta-arrestin-dependent, G-protein-independent signals (2008, NA)
• S-glutathionylation as a regulator of the JNK and MAPK signaling pathways in cancer (2008, NA)
• Downstream effects of Ras glutathionylation in response to exogenous peroxinitrite or oxLDL (2008, NA)
• Downstream effects of Ras glutathionylation in response to endogenous H2O2 production (2008, NA)
• Fluorescent assay formats used to characterize kinase inhibitors within the RAF-MEK-ERK pathway (2008, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–B Signaling (2008, Mus musculus,Homo sapiens)
• Molecular regulation of autophagy and the link with apoptosis (2008, NA)
• Signaling pathways involved in the co-stimulation of the canalicular targeting of AE2 and AQP8 by cAMP (2008, NA)
• Signaling pathways involved in the exocytic insertion of canalicular transporters promoted by cAMP and by TC and TUDC (2008, NA)
• Signaling pathways that regulate the cAMP-induced exocytic insertion of Ntcp into the basolateral membrane (2008, NA)
• TWEAK killing (2008, NA)
• Proposed model of arrest of maturation/activation of DCs via ILT4 receptor and HLA-G ligand (2008, Homo sapiens,Mus musculus)
• Schematic representations of the activated RAS-MAPK, RASSF1A/NORE1A, and Dab2IP/ASK1 pathways, iNOS signalling, and FOXM1-related pathways involved in the dysregulation of cell growth and apoptosis in HCC (2008, Mus musculus,Rattus norvegicus,Homo sapiens)
• The activated PI3K-AKT pathway and its downstream effectors that contribute to the tumorigenesis of TSHomas in TRBPV/PV mice (2008, NA)
• Association of Interacting Genes in the Toll-Like Receptor Signaling Pathway and the Antibody Response to Pertussis Vaccination (2008, NA)
• Putative site of action of PKCɛ in the amplification pathway of GSIS (2008, NA)
• Pathway of murine Th17 differentiation (2008, Escherichia coli,Mycobacterium tuberculosis,Klebsiella pneumoniae,Bacteroides fragilis,Citrobacter rodentium,Helicobacter hepaticus,Homo sapiens,Mus musculus,Candida albicans,Toxocara canis)
• The regulation of catabolic and anti-anabolic actions of FGF2 in intervertebral disc cells (2008, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus)
• Illustration of the Insulin Pathway and its Potential Contribution to High Salt-Induced Insulin Resistance in Dahl S rats (2008, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus 1,Lareunionomyces loeiensis)
• Signaling pathway for proceeding from FosB toward thrombospondin 1/TGFB1 (2008, NA)
• Platelet antistaphylococcal response mechanisms (2008, NA)
• Global regulation of the E (2008, NA)
• Molecular defect and phenotype in McCune-Albright syndrome (MAS) (2008, Homo sapiens,Diaporthe sclerotioides,Dipturus trachyderma)
• Signaling through PAK in the hyperosmotic response pathway (2008, NA)
• Role of Gas6 in erythropoiesis and anemia in mice (2008, NA)
• Regulation of glycolysis and fatty acid synthesis (2008, NA)
• Schematic models of the roles of Gab1 in IGF-I-dependent myogenic differentiation (2008, Mus musculus,Adenoviridae,Homo sapiens)
• p38 MAPK canonical signalling pathway (2008, NA)
• Stoichiometry of the glycolytic, fermentative, and tricarboxylic acid cycle (TCA) pathway (2008, NA)
• Proposed signaling mechanism that stimulates EMT (2008, Canis lupus familiaris,Homo sapiens)
• Summary of proposed TG-FN mediated RGD-independent cell adhesion pathway (2008, Mus musculus,Homo sapiens)
• IGF-1 activation of the survival PI3K/AKT pathway (2008, NA)
• Oct-4 Targets in the Wnt Signalling Pathway (2008, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Gallus gallus,Danio rerio,Origanum vulgare,Homo sapiens,Canis lupus familiaris,Middle East respiratory syndrome-related coronavirus)
• Type I IFN innate immune response to adenovirus-mediated IFNG gene transfer contributes to the regression of cutaneous lymphomas (2007, NA)
• Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network (2007, NA)
• Pathway Switching Explains the Sharp Response Characteristic of Hypoxia Response Network (2007, NA)
• Cell death in the cardiovascular system (2007, NA)
• Two tales concerning skeletal muscle (2007, NA)
• Alternative signaling: cardiomyocyte B1-adrenergic receptors signal through EGFRs (2007, NA)
• Beta-Arrestin–mediated B1-adrenergic receptor transactivation of the EGFR confers cardioprotection (2007, Mus musculus,Homo sapiens)
• Evolving biology and treatment of prostate cancer (2007, NA)
• Signaling cascades required for TCR-mediated integrin activation (2007, NA)
• PI3K activation by eIF2A kinases (2007, NA)
• Signaling pathways that are most likely to be implicated in the generation of DAG at the Golgi (2007, NA)
• Dd-STATa suppression by dutA overexpression (2007, NA)
• IFN signaling during the clinical evolution of SARS (2007, Homo sapiens,H5N1 subtype)
• In silico reconstruction of the Aspergillus CWIS pathway based on Aspergillus and S (2007, NA)
• Bacillus subtilis fermentation pathways (2007, Bacillus subtilis)
• The two pathways that make precursors for ester biosynthesis (2007, NA)
• Action for AICAR in human leukemia ALL cells (2007, NA)
• TGFB signaling pathway (2007, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt/Axin1/Beta-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries (2007, Gallus gallus,Danio rerio,Xenopus laevis,Oryzias latipes,Drosophila melanogaster,Caenorhabditis elegans,Phengaris arion,Mus musculus,Pinus torreyana,Homo sapiens)
• Different signaling pathway mediated by A3(IV)NC1 (2007, NA)
• Comparison between the gene expression profiles and predicted substrate uptake rates (2007, Escherichia coli)
• Ligands identified for EpCAM and possible functions related to them (2007, NA)
• Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events (2007, NA)
• RAN regulation pathway constituents exhibiting abundance changes, with a figure adapted from the GeneGo MetaCore database (2007, Human immunodeficiency virus 1)
• Upregulation of cyclins and CDKs in melanoma cells (2007, Homo sapiens,Mus musculus,Bos taurus)
• Striped view of multiple data types (2007, NA)
• Striped view of multiple time-point comparisons (2007, NA)
• LM5-mediated survival (2007, NA)
• Vicious cycle in osteolytic bone metastasis (2007, Mus musculus,Rattus norvegicus,Homo sapiens)
• Essential signaling pathway for normal osteoclastogenesis (2007, NA)
• WNT signalling KEGG pathway consisting of three subpathways with the genes on the microarray encircled (A) and expression profiles of genes during porcine myogenesis (B) (2007, Gallus gallus,Coturnix coturnix,Homo sapiens,Mus musculus,Drosophila melanogaster,Sus scrofa,unidentified)
• Notch signalling pathway derived from the KEGG database with the genes on the microarray encircled (A) and their corresponding expression profiles of genes during porcine myogenesis (B) (2007, Gallus gallus,Coturnix coturnix,Homo sapiens,Mus musculus,Drosophila melanogaster,Sus scrofa,unidentified)
• The p110D → RhoA → PTEN signalling pathway described in the text (2007, Mus musculus,Homo sapiens)
• Anoxia on carbohydrate metabolism in rice coleoptiles (2007, NA)
• Arginine catabolic pathways in P (2007, Pseudomonas aeruginosa)
• Sensitivity Analysis of Intracellular Signaling Pathway Kinetics Predicts Targets for Stem Cell Fate Control (2007, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Osteoclast differentiation (2007, Mus musculus,Homo sapiens)
• In silico modeling derived from Pathway Assist software analysis of differential gene expression in JRA neutrophils compared with healthy control subjects (2007, NA)
• Hepcidin regulation: ironing out the details (2007, NA)
• Schematic model of Zfra/WOX1 involvement in TNF signaling (2007, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Vasconcellea candicans,Chlorocebus aethiops,Neogale vison,Drosophila melanogaster,vectors,Dipturus trachyderma)
• Induction of KSHV reactivation by metabolic end products from gram-negative bacteria, which contain high levels of butyric acid, inhibit cellular HDACs, and activate the p38 kinase pathway (2007, NA)
• HCMV MIE promoter/enhancer and its cis-acting elements (2007, NA)
• Signaling pathways activated by mitogenic concentrations of TNFA and roles of furin, MT1-MMP, and MMP2 in the activation of the nSMase in mesenchymal cells (2007, Mus musculus,Oryctolagus cuniculus,Homo sapiens)
• Molecular mechanisms of JNK activation by p85 (2007, NA)
• The role of FoxO4 in phenotypic modulation of SMCs in response to cytokine and growth factor signals (2007, NA)
• Regulation of dimorphism in C (2007, Candida albicans,Homo sapiens)
• Mating pheromone signaling pathway in S (2007, NA)
• PTS and the proposed Mif pathways (2007, NA)
• Late steps in corrin ring biosynthesis in serovar Typhimurium (2007, NA)
• GM-CSF Regulates a PU.1-Dependent Transcriptional Program Determining the Pulmonary Response to LPS (2007, Mus musculus,Pseudomonas aeruginosa,Homo sapiens)
• Signaling pathways downstream of the Toll/TLRs (2007, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Nematostella vectensis,Bilateria,Hydra vulgaris,Acropora millepora,Haliotis corrugata,Suberites domuncula,Eumetazoa,Acropora palmata,Tachypleus tridentatus,Porites lobata,Anthopleura elegantissima,Ephydatia fluviatilis,Hydractinia echinata,Millepora dichotoma,Montipora verrucosa,Hydractinia symbiolongicarpus,Phymactis clematis,Anthopleura xanthogrammica,Eunicella stricta,Heliocidaris erythrogramma,Heliocidaris tuberculata,Arabidopsis thaliana,Pyrus communis,Homo sapiens,Mus musculus)
• Diagram of common stress response pathway genes (2007, NA)
• The secretory pathway under different ER stress conditions (t-PA secretion, tunicamycin and DTT) together with examples of genes that are transcriptionally induced or repressed (2007, NA)
• Discovery of Aspirin's Antithrombotic Effects (2007, NA)
• Regulation of hypoxia-inducible factor-1A (HIF-1A) and drug interventions currently in use (2007, Homo sapiens)
• Image showing the human insulin signaling pathway from BioCarta (2007, NA)
• Cyclic AMP pathways in myometrial tissue (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Xenopus laevis)
• Chirality axes (A) and possible regulators of leftward polarity bias (B) (2007, NA)
• STATc is a key regulator of the transcriptional response to hyperosmotic shock (2007, NA)
• Web-accessible pathway navigator (2007, NA)
• Proposed signaling regulation of MT1-MMP and Sp1 in prostate cancer cell lines (2007, NA)
• PDCD10/MST4 signaling pathway and CCM protein function (2007, NA)
• Nutritional Route Affects ERK Phosphorylation and Cytokine Production in Hepatic Mononuclear Cells (2007, NA)
• Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR (2007, NA)
• Genomic organization of the CDKN2A locus and description of involvement of its transcripts (p16INK4a and p14ARF) in the Rb and p53 pathways (2007, NA)
• Pathway diagram developed using the Ingenuity Pathways Analysis and Knowledge Base in which all genes changed by more than 1.5 fold were queried (2007, NA)
• Hedgehog signalling pathway (2007, NA)
• Nef-induced signaling in monocytes/macrophages (2007, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens)
• Model showing the proposed dual role of Ipl1p in promoting chromosome biorientation and checkpoint activation in response to mono-oriented chromosomes (2007, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Signal-transduction pathways for actin assembly (2007, NA)
• Novel TLR4-Mediated Signaling Pathway Leading to IL-6 Responses in Human Bladder Epithelial Cells (2007, Escherichia coli,Mycolicibacterium smegmatis,Mycobacterium avium,Yersinia enterocolitica,Mus musculus,Cavia porcellus,Homo sapiens)
• Altered macrophage differentiation and immune dysfunction in tumor development (2007, NA)
• DC-based cancer vaccines (2007, Homo sapiens)
• Canonical Wnt signalling pathway and its APC partner in colon cancer development (2007, NA)
• Canonical Wnt signalling pathway and its APC partner in colon cancer development (2007, NA)
• Canonical Wnt signalling pathway and its APC partner in colon cancer development (2007, NA)
• Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications (2007, NA)
• Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications (2007, NA)
• Mutational Analysis of EGFR and Related Signaling Pathway Genes in Lung Adenocarcinomas Identifies a Novel Somatic Kinase Domain Mutation in FGFR4 (2007, NA)
• Working model for the caveolin-dependent trafficking of M1 muscarinic receptor (2007, Canis lupus familiaris,Homo sapiens)
• Schematic depiction of the molecular mechanism for the progression from HPS to chronic active disease or T-cell lymphoma in EBV-infected T cells (2007, NA)
• DAF-2 signaling (red pathway) opposes degradation-promoting signal from FGFs (green pathway) (2007, NA)
• Retinoic acid (RA) signaling pathway and CDH candidate genes (2007, NA)
• Illustration of key proteins in the Rho GTPase signal–transduction pathway, focusing on the KALRN, CDGAP, and MYLK genes (2007, NA)
• Multiple estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid are implicated in estrogen-dependent growth of human uterine fibroids (2007, NA)
• Proposed roles of HRI signaling pathway in stress erythropoiesis (2007, NA)
• Diagram of folate and one-carbon metabolism in mammalian organisms (2007, NA)
• Regulation of cyclin D1 degradation (2007, NA)
• SFK-dependent PI3K-ERK2 and phospholipase CG-JNK1 pathways (2007, NA)
• Working model for CARMA3-mediated NFKB activation in GPCR signal transduction pathway (2007, NA)
• Signaling pathways mediating the roles of Rho1 in cell wall assembly and actin organization (2007, Homo sapiens,Saccharomyces cerevisiae)
• Signaling pathways leading to pseudohyphal growth (2007, Homo sapiens,Saccharomyces cerevisiae)
• Visualization of a single cell (2007, Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Homo sapiens,Mus musculus,Escherichia coli,unidentified)
• gp130 receptor ligands as potential therapeutic targets for obesity (2007, NA)
• Roles of p16INK4a/RB-pathway in senescence cell cycle arrest (2007, Homo sapiens,Mus musculus,Betapolyomavirus macacae,NA)
• Dynamic Simulations on the Arachidonic Acid Metabolic Network (2007, NA)
• Hypothetical regulatory network influencing honeybee pollen foraging behavior modulated by insulin-like signaling and its effects on ovarian development (2007, Drosophila melanogaster,Apis mellifera,Drosophila simulans,Mayetiola destructor,Drosophila sechellia,Apis mellifera scutellata,Mus musculus,Rattus norvegicus,Triticum aestivum,Matthiola incana,Homo sapiens,Sus scrofa)
• Hyperglycemia, derangement of cell metabolism and oxidative/nitrosative stress (2007, Homo sapiens)
• TGFB signaling pathway (2007, Canis lupus familiaris,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples,Campanula medium)
• Model: How PP1 regulates the Wnt signaling pathway (2007, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Representation of TLR4-signaling through the MyD88-dependent and MyD88-independent pathways (2007, NA)
• Osteopontin/AvB3 signaling in the regulation of prostate cancer cell migration (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Matthiola incana)
• Ras signaling pathway relays growth signals from activated growth factor receptors to the nucleus (2007, Homo sapiens,Mus musculus)
• MAPK pathway (2007, NA)
• GPCR-mediated activation of MAPKs is also regulated by the generation of intracellular messengers (2007, NA)
• Synergistic effect of cell contact injury and TGFB1 in the complex regulation of the SMA promoter (2007, Mus musculus,Homo sapiens)
• ECM remodeling in hypertensive heart disease (2007, Homo sapiens)
• Systemic sclerosis: a prototypic multisystem fibrotic disorder (2007, NA)
• The yeast response to osmotic and calcium stress (2007, Saccharomyces cerevisiae,Homo sapiens)
• Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages (2007, NA)
• Biosynthesis of pyruvate and its end products in “amitochondriate” protozoan parasites (2007, NA)
• Strategies of the different HCV proteins to antagonize IFN therapy (2007, Homo sapiens,NA)
• Working model for NS action (2007, NA)
• Complete pyrene degradation pathway in M (2007, Mycolicibacterium vanbaalenii PYR-1)
• Flux distribution in D (2007, NA)
• Pathway of double-stranded break repair by homologous recombination and the factors involved (2007, NA)
• Human and mouse mutations and the cognitive disorders affecting specific NRC/MASC signaling pathways and other postsynaptic proteins (2007, Homo sapiens,Mus musculus)
• PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase (2007, NA)
• Exploitation of Eukaryotic Ubiquitin Signaling Pathways by Effectors Translocated by Bacterial Type III and Type IV Secretion Systems (2007, Escherichia coli,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Agrobacterium tumefaciens,Pseudomonas syringae,Shigella flexneri,Legionella pneumophila,Yersinia pestis,Pseudomonas syringae pv. tomato str. DC3000,Ralstonia solanacearum,Pseudomonas syringae pv. tomato,Yersinia enterocolitica,Yersinia pseudotuberculosis,Mesorhizobium loti,Candidatus Sodalis pierantonius str. SOPE,Pseudomonas savastanoi pv. phaseolicola,Rickettsia conorii,Salmonella sp.,Yersinia sp. in enterobacteria,Legionella pneumophila str. Paris,Candidatus Protochlamydia amoebophila UWE25,Salmonella enterica subsp. enterica serovar Pullorum,Xanthomonas sp.,Chlamydia sp.,Mesorhizobium japonicum R7A,Pseudomonas syringae group genomosp. 3,Saccharomyces cerevisiae,Arabidopsis thaliana,Solanum lycopersicum,Medicago truncatula,Nicotiana benthamiana,Venustaconcha ellipsiformis,Heterodera glycines,Homo sapiens,Mus musculus)
• CCM2 as a Scaffold for p38 MAPK Activation (2007, NA)
• Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis (2007, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Schematic illustrates physiological and pathological signaling cascades (2007, NA)
• Dominant role for glucose in B cell compensation of insulin resistance (2007, NA)
• Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737 (2007, NA)
• Inflammatory pathway in psoriasis (2007, NA)
• Anti-apoptosis of families of HSPs (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Adeno-associated virus)
• Proposed signaling pathways associated with the gastrinreleasing peptide receptor (GRPR) in the central nervous system (2007, NA)
• Cellular response to IFNs (2007, NA)
• Type I IFN gene expression (2007, NA)
• AKT and ERK signaling pathway (2007, NA)
• Effect of oral foreign plasmid pcDNA3 on complement activation classical pathway (2007, NA)
• Effect of orally administered foreign plasmid pDNA3 on proteasome degradation pathway (2007, NA)
• Possible mechanisms for neuroprotection of G-CSF in cerebral ischemia and neurodegeneration (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Xenopus laevis,Lacticaseibacillus rhamnosus)
• Dual role of Cav-1 Y14 phosphorylation: phosphorylat-ed caveolin (pYCav-1) is involved in the control of integrin-mediated signal transduction and caveolae-mediated cholesterol-enriched membrane microdomains (CEMM) endocy-tosis (2007, NA)
• TLR4 signaling pathway and its relation with atherosclerosis (2007, NA)
• During the initial phase of breast tumourigenesis, the TGFB signal inhibits primary tumour development (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,Ziziphus mauritiana)
• Effect of ischaemic preconditioning and its effectors on the signaling pathways of liver regeneration (2007, NA)
• Potentiation of growth factor signaling pathways involved in cell cycle progression in liver regeneration (2007, NA)
• Canonical Wnt/Beta-catenin signalling pathway (2007, NA)
• E2F1-induced apoptosis (2007, Homo sapiens,Mus musculus,Drosophila melanogaster,Sus scrofa,Vasconcellea candicans)
• Diagram showing the crosstalk between the DNA damage response pathway and BMP-controlled osterix expression and osteoblast differentiation (2007, Homo sapiens,Mus musculus,NA)
• Glutamate and dopamine signaling pathways act synergistically to induce Ca2+ overload and apoptosis of HD MSNs (2007, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Wnt signaling pathway is regulated by SFRPs, epigenetic gatekeepers and APC; a genetic gatekeeper (2007, NA)
• Regulation of apoptosis (2007, NA)
• WNT/Beta-catenin signaling pathway (2007, NA)
• EGF receptor-signal transduction pathway (2007, Homo sapiens)
• The two modes of Gq/11-coupled receptor mechanisms in SCG neurons (2007, Rattus norvegicus,Homo sapiens)
• Summary of the effects of DA on synaptic integration (2007, Rattus norvegicus,Homo sapiens)
• Regulation of vasopressin gene expression in the SCN (2007, NA)
• Proposed pathways that regulate spine density and that are affected by AB oligomers, based on the results of this study (2007, Homo sapiens,Rattus norvegicus)
• Role of neurofibromin (NF-1) in the regulation of intracellular Ras signaling within DRG neurons (2007, NA)
• Scheme indicating differences between human primary neurons and neuroblastoma cells with respect to the production of kynurenine pathway metabolites and their effects in tumor persistence and the immune response (2007, NA)
• Model depicting a novel, early signaling cascade linking group I mGluR stimulation to FMRP phosphorylation through mTOR and PP2A (2007, NA)
• Hypothetical pathway by which isoflurane induces a vicious cycle of apoptosis and AB generation and aggregation (2007, Homo sapiens)
• Pathways for energy production in astrocytes: effects of CNTF (2007, NA)
• Drivers of senescence and therapeutic opportunities in WS and HGPs (2007, NA)
• Model depicting the E2Fs-FA/BRCA axis in the control of cell fate (2007, Homo sapiens,Bos taurus)
• Different signaling pathway mediated by A3(IV)NC1 (2007, Homo sapiens,Mus musculus,Bos taurus)
• Distinct signaling pathways induced by A2(IV)NC1 (2007, Homo sapiens,Mus musculus,Bos taurus)
• Signaling pathway mediated by A1(IV)NC1 (2007, Homo sapiens,Mus musculus,Bos taurus)
• Signalling events which determine glucose utilization within the cell (2007, Canis lupus familiaris,Sus scrofa,Felis catus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Citrus macrophylla,Homo sapiens,Human papillomavirus type 16,Deinococcus radiodurans)
• Simplified scheme of the VEGF/VEGFR pathway (2007, Homo sapiens)
• RAS/MAP kinase signaling pathway (2007, Homo sapiens,Rattus norvegicus)
• Different mechanisms of RTK signal attenuation (2007, NA)
• VEGF receptor-induced signaling pathway (2007, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Macaca mulatta,prion,Trypanosoma cruzi,Tequatrovirus T4)
• Signaling pathways initiated by TLR-2 and TLR-4 activation (2007, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Corynebacterium phage gamma,Moraxella catarrhalis)
• Emerging anti-inflammatory therapy (2007, NA)
• A, Potential mechanism of action of AB*56 at neuronal surface (2007, NA)
• Simplified schematic diagram of transforming growth factor-alpha/epidermal growth factor receptor signaling pathway (TGFA/EGFR) (2007, NA)
• Simplified schematic diagram of insulin-like growth factor (IGF) signaling (2007, NA)
• In the absence of Wnt stimulation, the APC (adenomatous polyposis coli) forms a trimeric complex, known as the “destruction complex,” with glycogen synthase kinase-3B (GSK) and Axin (2007, NA)
• Signalling through the phosphatidylinositol 3-kinase (PI3K) affects cell growth, apoptosis and cell cycle regulation (2007, NA)
• The role of microRNAs in the regulation of ‘tumor suppressor’ pathways in Drosophila (2007, NA)
• CATERPILLER (NLR) Family Members as Positive and Negative Regulators of Inflammatory Responses (2007, NA)
• Novel Insights into Lung Transplant Rejection by Microarray Analysis (2007, NA)
• Advances on the Understanding of the Origins of Synaptic Pathology in AD (2007, NA)
• Schematic representations of potential signaling pathways involved in serum-deprived retinal ganglion cell-5 cells (2007, NA)
• MAPK family with its classical cascades, the ERK 1 and 2,p38 and JNK (2007, Mus musculus,Rattus norvegicus,Castor fiber,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Xenopus laevis)
• Amino acid transporters and nutrient sensing mechanisms (2007, NA)
• Illustration of the dual roles of the ABP1 and TIR1 auxin receptors in control of the cell cycle (2007, NA)
• Al3+ effect on phospholipid signalling, and its possible consequence on other cell signaling components (X, inhibition of the pathway by Al3+) (2007, NA)
• Model summarizing some of the pathways described in this review leading to chemotaxis and cell motility (2007, Homo sapiens)
• Possible mechanisms of tip cell selection through modulation of different components of the VEGF signalling pathway following Notch signalling (2007, NA)
• Proposed mechanism of PDGF signaling in the lens epithelial cells (2007, NA)
• Ras signalling pathways (2007, NA)
• EGFR signalling pathway in lipid rafts (2007, Homo sapiens)
• Simplified network involved in the invasive growth in haploids (2007, NA)
• The co-ordinated activation of pro-inflammatory signalling pathways by TLR ligands and the pro-inflammatory cytokines TNFA, IL-1 and IFN (2007, NA)
• Examples of the molecular mechanisms by which phytochemicals activate hormetic stress response pathways (2007, Homo sapiens)
• Integration of the TGFB1 apoptotic signal by the lipid oxidation end-product 4-hydroxynonenal (2007, NA)
• Points of action of flavonoids within PI3K/Akt signalling pathway (2007, NA)
• Points of action of flavonoids within p38 pathway (2007, NA)
• Points of action of flavonoids within JNK pathway (2007, NA)
• Contribution of If to sinoatrial (SA) node action potentials and autonomic modulation of heart rate (2007, NA)
• Regulation of post-cushion valve maturation to thin fibrous leaflets also includes EGF receptor signalling in addition to differential signalling of the pathways in c (2007, NA)
• Example of EGFR-mediated signaling changes, a commonly disrupted pathway in lung cancer (2007, NA)
• Network diagram comprising genes and functional processes associated with regulated AS events in the CNS (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Pandion haliaetus)
• Contextual organization of the NFKB positive modulators (2007, Matthiola incana,Prunus persica,Iris germanica,Homo sapiens,Mus musculus,Bos taurus,vectors)
• Schematic depicting the central role of HER3 in mediating PI3K/Akt signalling downstream of the HER family (2007, NA)
• c-MET/HGF signal transduction pathways in SCLC (2007, NA)
• Activation of the RAS–RAF–MEK pathway in thyroid cancer (2007, Homo sapiens,Mus musculus,clinical samples)
• Proposed mechanism for RES induced apoptosis in LNCaP and PC-3 human prostate tumour cells (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Metabolism of PtdIns(4,5)P2 by PLCG and PI3K (2007, NA)
• Beta-AR-mediated cardiomyocyte contractility (2007, NA)
• Critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats (2007, Mus musculus,Rattus norvegicus,Homo sapiens)
• CAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes (2007, Homo sapiens,Rattus norvegicus,Adenoviridae)
• Activation of Epac by cAMP and activation of CaMKII-dependent phosphorylation of the RyR Broken lines and question marks indicate aspects where the possible pathway requires further tests (2007, NA)
• EPAC regulation of cardiac EC coupling (2007, NA)
• The regulation of SCD1 gene transcription in hepatic cells (2007, Gallus gallus,Homo sapiens)
• PI3K/AKT signaling pathway activated by 3Alpha-diol (2007, Homo sapiens)
• Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110A and B by protease-activated receptor 2 and Beta-arrestins (2007, Mus musculus,Homo sapiens)
• Osteoblast and osteoclast function induced by Wnt signalling (2007, NA)
• Kinetic model of the NSCLC-specific EGFR signaling pathway (2007, Homo sapiens,Rattus norvegicus,Helicobacter pylori,Cerobasis alpha)
• Growth factors trigger local and long distance signalling (2007, NA)
• Proposed mechanism for MnSOD-mediated mitochondria to nucleus signaling and crosstalk with the IIS pathway (2007, NA)
• Gene expression changes observed in Sema3A signaling pathway (2007, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Chlorocebus aethiops,Drosophila melanogaster)
• HER2/HER3 activation in breast cancer cells (2007, NA)
• Wingless and integration site growth factor (WNT)-induced epidermal growth factor receptor (EGFR) transactivation (2007, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana,Xenopus laevis,Retroviral vector pLNCX)
• Cholesterol biosynthesis pathway (2007, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Drosophila melanogaster)
• Genes involved in apoptotic pathways were altered in type II cells isolated from Stat3Δ/Δ mice (2007, NA)
• PI3K-AKT pathway is transcriptionally regulated throughout the lactation cycle (2007, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Mouse mammary tumor virus,Homo sapiens,Bos taurus)
• Possible signaling pathway for carbachol-induced pigment granule dispersion in bluegill RPE (2007, NA)
• Rosilitazone stimulates NSCLC proliferation by affecting the Akt/mTOR pathway through PPARGamma-dependent and PPARGamma-independent mechanisms (2007, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Glycyrrhiza uralensis,Homo sapiens,Xenopus laevis)
• Signaling Pathway Involved in Neutrophil Elastase–Stimulated MUC1 Transcription (2007, NA)
• Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients (2007, Homo sapiens)
• Proposed model for UV-B mediated signal transduction pathway leading to activation of the TIA pathway (2007, NA)
• Differences in signaling pathway activation of mechanical ventilation with and without hyperoxia (2007, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana)
• Cell cycle pathway diagram obtained from GenMAPP (Gene Map Annotator and Pathway Profiler, Gladstone Institutes, University of San Francisco, San Francisco, CA [38] (2007, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Actaea cimicifuga,Actaea racemosa,Achaea serva,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Possible mechanism for endocannabinoid-mediated control of nociception (2007, NA)
• Carbon Monoxide and Bilirubin (2007, NA)
• Lipid Mediators as Agonists for the Resolution of Acute Lung Inflammation and Injury (2007, NA)
• Protein regulatory network indicates importance of ISGylation pathway in TLR7-mediated activation of pDC (2007, NA)
• Transcription regulatory network indicates utilization of various transcription factors following activation of TLR7 (2007, NA)
• Schematic view of Ras- and calcineurin-dependent pathways in T cells (2007, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of the AHR-XRE pathway by NRF2 (2007, NA)
• Matrilysin and stromelysin-2 differentially control apoptotic transcriptional response (2007, NA)
• HIF-1A up-regulation and ubiquitination pathway (2007, Homo sapiens,Mus musculus,Bos taurus)
• Signal transduction pathways in eukaryotic chemotaxis (2007, Escherichia coli,Thermotoga maritima,Candidatus Sodalis pierantonius str. SOPE,Danio rerio,Calloplesiops altivelis,Homo sapiens,Dictyostelium discoideum)
• DARPP-32 regulatory pathways (2007, NA)
• GenMAPP pathway showing changes in expression of the transcription factor PPARA and fatty-acid degrading enzymes upon fasting (2007, Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Proteosomal degradation pathway (2007, Homo sapiens,Mus musculus)
• GenMAPP view of energy production pathway in MCF-7 and ZR75-1 cells (2007, Homo sapiens,Mus musculus)
• MTA family of coregulators in nuclear receptor biology and pathology (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Proposed model of RasGRP1 in FcɛRI-mediated signaling (2007, NA)
• Schematic overview of the RANK-NFKB signalling pathway (2007, NA)
• Current model of the Fanconi anemia pathway (2007, Saccharomyces cerevisiae,Arabidopsis thaliana,Gallus gallus,Danio rerio,Xenopus laevis,Curcuma longa,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Filamentation signaling pathway recovered completely (2007, NA)
• Filamentation signaling pathway (2007, NA)
• Schematic model of Nrf2 regulation by Keap1 (2007, NA)
• Circadian oscillation in leptin signaling pathway in mouse brown fat (2007, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Summary of purinergic pathways involved in microglial response (2007, NA)
• Synergistic effects of RXRA and PPARG ligands to inhibit growth in human colon cancer cells—phosphorylated RXRA is a critical target for colon cancer management (2007, Homo sapiens)
• Relative transcript levels for genes from carbon central metabolism for L-Phe overproducing strains (2007, Escherichia coli,Homo sapiens)
• Relative transcript levels for genes from carbon central metabolism for PB12 (first value) and PB13 (second value), as compared to JM101 (2007, Escherichia coli,Homo sapiens)
• Myc and Ca2+signaling events downstream of the pre-BCR/BCR (2007, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Matthiola incana,Patella vulgata,murine stem cell retroviral vector)
• Putative major cardioprotective signal transduction cascades downstream of cGMP-dependent protein kinase (PKG) (2007, NA)
• Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy (2007, NA)
• Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle (2007, NA)
• IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice (2007, NA)
• Divergent TGFB signaling pathways induce transcriptional regulation through Smads and translational regulation through the mTORC1 pathway (2007, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• New calpain-dependent switch that controls cell spreading and retraction (2007, NA)
• Signaling cascades leading to D (2007, NA)
• OX40 signaling directly triggers the antitumor effects of NKT cells (2007, Mus musculus,Homo sapiens)
• KEGG metabolic pathway "Valine, leucine and isoleucine degradation" (2007, NA)
• Proposed regulatory links between the SAPK and the cell integrity pathways by protein phosphatases (shaded figures) during growth and osmostress (2007, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Schematic outline of fatty acid synthesis in apicomplexans (2007, NA)
• Biphasic expression and up-regulation of HWP1 at the bud-hypha transition (2007, Candida albicans)
• PTEN/PI3K/mTOR/STAT3 signaling involved in breast cancer stem-like cell survival and proliferation (2007, Homo sapiens,Mus musculus)
• Notch pathway is a frequent target of insertion (2007, NA)
• Noxa and Mcl-1 in the regulation of CPT-induced apoptosis (2007, NA)
• K13 Blocks KSHV Lytic Replication and Deregulates vIL6 and hIL6 Expression: A Model of Lytic Replication Induced Clonal Selection in Viral Oncogenesis (2007, Human gammaherpesvirus 4,Human gammaherpesvirus 8,Simian sarcoma-associated virus,Homo sapiens,Mus musculus,Oryctolagus cuniculus,murine stem cell retroviral vector,NA,NA)
• Schematic diagram illustrating potential mechanisms involved in the synergistic activation of cAMP signaling pathway by NO and IM (2007, NA)
• Signalling pathways activated by the RXFPs (2007, NA)
• F igure 6.— (2007, Caenorhabditis elegans,Homo sapiens)
• Arterial–venous specification in the developing embryo (2007, NA)
• Cross-talk between signal transduction pathways and ER signaling in endocrine resistant breast cancer, with opportunities for targeted intervention (2007, Homo sapiens,Mus musculus)
• E2-induced pathway in the luminal epithelium that leads to the canonical cell cycle machinery (2007, NA)
• Flow diagram of the P53/apoptosis pathway (2007, Homo sapiens,unidentified)
• Pathways involved in GSIS (2007, NA)
• New molecularly targeted therapies for lung cancer (2007, NA)
• New molecularly targeted therapies for lung cancer (2007, NA)
• Model summarizing the hypothesis on narciclasine-mediated apoptosis (2007, Homo sapiens)
• Ingenuity pathway analysis showing regulatory relationships among differentially expressed transcripts (2007, NA)
• Signaling of Human Frizzled Receptors to the Mating Pathway in Yeast (2007, NA)
• Linking Metabolic QTLs with Network and cis-eQTLs Controlling Biosynthetic Pathways (2007, NA)
• Linking Metabolic QTLs with Network and cis-eQTLs Controlling Biosynthetic Pathways (2007, NA)
• Regulation of intracellular cAMP in platelets by thrombin (2007, Homo sapiens)
• BDCA2/FcERIG Complex Signals through a Novel BCR-Like Pathway in Human Plasmacytoid Dendritic Cells (2007, NA)
• Pathways involved in mesenchymal cell proliferation and differentiation induced by G protein coupled receptors (GPCRs) (2006, NA)
• Aspartate and aspartate transport in the pathway of prostate citrate production (2006, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Armoracia rusticana)
• Synthesis, degradation and mode of action of retinoic acid (RA) (2006, NA)
• Pathway analysis (2006, NA)
• How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome (2006, NA)
• Pathway analysis (2006, NA)
• Pathway analysis (2006, NA)
• EPS-8 function during vulval fate specification (2006, Caenorhabditis elegans,Homo sapiens)
• Major G-alpha-signaling pathways (2006, Caenorhabditis elegans,Homo sapiens)
• Schematic depiction of the proposed function of the Cdc42-Ste50-RA domain and Ste11-Ste50-SAM domain interactions in filamentous growth and HOG pathway signaling (2006, NA)
• Spatial segregation of neuronal calcium signals encodes different forms of LTP in rat hippocampus (2006, Rattus norvegicus,Homo sapiens)
• TH1 cell immune response by Treg cells and CAM (2006, NA)
• TNF receptor (TNFR) pathway of signaling (2006, Homo sapiens,Mus musculus,Candida dubliniensis,unidentified influenza virus)
• Sequence of events in ATM→ ATR dependent signaling of DSBs in S/G2 cells (2006, NA)
• Proposed role of PI3K/Akt signalling pathway in the regulation of GLUT5 synthesis and trafficking (from Cui et al, 2005) (2006, NA)
• Molecular pathways contributing to the phenotype of microsatellite stable (MSS) CRC (2006, NA)
• Proposed hypothetical model of the mini-dystrophin reduction effect on PLC activity (2006, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• A proposed molecular mechanism leading to nr PN death (2006, NA)
• Scheme of trafficking pathways used by PyV for the movement towards the cell nucleus (2006, NA)
• Signaling events during EMT (2006, NA)
• The newly identified NT3-activated signaling pathway (2006, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,Escherichia coli BL21)
• Epidermal growth factor receptor pathway (2006, NA)
• Model showing how altered cytoarchitecture and diminished scaffolding function of keratin networks could lead to up-regulation of the Erk1/2 pathway in plectin-deficient keratinocytes (2006, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,NA)
• Common oxidant sources signal through a variety of pathways (2006, NA)
• NK-B/TXA2 regulatory axis (2006, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus,Escherichia coli,Gallus gallus)
• Model integrating calcium mobilization into the Fas signaling pathway (2006, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Vasconcellea candicans)
• Identification of a Bcr-Abl kinase signature (2006, Homo sapiens)
• TGFB signaling pathway and mechanisms of inhibition during leukemogenesis (2006, NA)
• Prosurvival signaling pathways and their downstream targets (2006, NA)
• Diagram illustrating Functional JAK STAT PathwayThis “JAK STAT” pathway appears to be ubiquitous amongst vertebrates (2006, NA)
• Molecular system bioenergetics: regulation of substrate supply in response to heart energy demands (2006, NA)
• Proposed Receptor Ck – dependent signaling pathway involved in hTERT gene regulation at the transcriptional level (2006, NA)
• P2Y receptor-mediated signalling cascades in C6 cells (2006, NA)
• Proposed model of mechanism by which inhibition of PKA phosphorylation of RyR2 prevents intracellular Ca2+ leak in heart failure (2006, NA)
• Role of interleukin 6 in a murine model of Crohn's ileitis: are cytokine/anticytokine strategies the future for IBD therapies? (2006, NA)
• PPARG as a new therapeutic target in inflammatory bowel diseases (2006, Homo sapiens)
• Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction (2006, NA)
• Molecular characterisation of non‐absorptive and absorptive enterocytes in human small intestine (2006, Homo sapiens)
• ERK1/2 pathway in airway epithelial cell responses to cigarette smoke (2006, NA)
• Proposed model showing the mechanisms underlying A1- and A2-adrenergic regulation of NMDAR function in PFC pyramidal neurons (2006, Mus musculus,Rattus norvegicus,Homo sapiens)
• C-Peptide in Insulin Resistance and Vascular Complications (2006, Canis lupus familiaris,Homo sapiens)
• Diabetes and Alzheimer's Disease - Is There a Connection? (2006, NA)
• Mechanisms by which 12/15-LO may regulate ICSBP (2006, Homo sapiens,Mus musculus)
• CD40 signaling regulates angiogenesis (2006, Homo sapiens,Mus musculus,Candida dubliniensis,Mouse mammary tumor virus)
• The signalling pathways involved in Pam3Cys-induced degranulation and cytokine/chemokine production in human LAD 2, MLMC and BMMC (2006, NA)
• AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance (2006, NA)
• AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues (2006, NA)
• New Approaches to Vaccine Adjuvants: Inhibiting the Inhibitor (2006, NA)
• AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer (2006, NA)
• AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer (2006, NA)
• Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders (2006, NA)
• Autophosphorylation of ACaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse (2006, NA)
• PD‐0200347, an A2D ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCA dependent effect (2006, Canis lupus familiaris,Cervus elaphus,Homo sapiens)
• Endocrine resistance and its treatment: crosstalk between growth-factor receptor and ER pathways (2006, Homo sapiens)
• Novel therapeutic targets and proposed mechanisms of androgen resistance (text in red) in hormone refractory prostate cancer (2006, NA)
• Exploitation of the Toll-like receptor system in cancer (2006, NA)
• Ciliated cell differentiation into goblet cells requires 2 signals (2006, Mus musculus,Homo sapiens)
• Biochemical pathways for LTM formation in associative olfactory conditioning (2006, NA)
• Cytoplasmic/traditional and nuclear modes of the EGFR signalling pathway (2006, Mus musculus,Rattus norvegicus,Homo sapiens)
• Overview of signal transduction pathways and role of selective inhibitors (2006, Homo sapiens,Saccharomyces cerevisiae)
• Differential targets of copy number-induced expression changes in key biochemical pathways between SCLC and NSCLC (2006, Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Mus musculus,Xenopus laevis,Pekania pennanti)
• Models of estrogen action (2006, Homo sapiens)
• TGF–TAK1 pathway (2006, NA)
• TGFB1–Smad pathway (2006, NA)
• Diagram of the Ras/Raf/MEK/ERK pathway, showing the possible distinct functions for ERK1 and ERK2 (2006, NA)
• 2B synaptic or extrasynaptic determines signalling from the NMDA receptor (2006, NA)
• Recent observations on the regulation of fetal metabolism by glucose (2006, NA)
• Effect of 30 per cent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression (2006, NA)
• An extension of the Calvin pathway by the inclusion of an octulose phosphate shunt (vide infra) (2006, NA)
• The complement cascade (2006, NA)
• Mitogen-activated protein kinase (MAPK) intracellular signalling pathway (2006, Homo sapiens)
• Phosphatidylinositol 3-kinase (PI3K) intracellular signalling pathway (2006, Homo sapiens)
• GA12-mediated activation of PDGFRA signaling pathway (2006, Homo sapiens,Mus musculus)
• Functional dissection of signaling modules in human TReg cells (2006, Homo sapiens,Mus musculus,Bos taurus,Arabidopsis thaliana,Middle East respiratory syndrome-related coronavirus)
• Signaling pathways activated by serum and GF treatments (2006, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Escherichia coli)
• General and gene-specific transforming growth factor (TGF)B signaling in fibroblasts (2006, NA)
• Signaling network in neurons Schematic overview of signaling pathway modules in neuronal cells (redrawn from Bhalla [82]) (2006, Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Escherichia coli)
• WNT Pathways (2006, Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Escherichia coli)
• Prostanoids biosynthetic pathway (2006, NA)
• Signaling Pathways in Yeast (2006, Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Escherichia coli)
• Complement system consists of about 30 proteins that can be activated by 3 different cascades (2006, NA)
• Dox and VP16 signaling pathway in NB (2006, NA)
• Association between human TLRs and adaptors determine each TLR-specific signaling pathway (2006, NA)
• Proposed model of lacritin mitogenic signaling pathway lacritin signaling suggested by data outlined in the text (2006, NA)
• Two signaling pathways of TLR in myeloid DCs (2006, NA)
• Development of the intracellular signalling mechanisms involved in smooth muscle contraction and relaxation, between 1975 and 2005 (2006, NA)
• Unraveling the Genetics of Human Obesity (2006, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• In normal prostate epithelial cells (a), TGFB binds to the TBRI and TBRII receptors, activating the SMAD signalling pathway and inducing the transcription of IGFBP-3 and other regulatory genes (2006, NA)
• Inhibitory signals of the Toll-like receptor (TLR)4-induced MyD88-dependent signaling pathway (2006, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Streptococcus pyogenes,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Cryptococcus neoformans,Plasmodium cynomolgi,NA)
• Schematic pathway of prostanoids formation and actions (2006, Homo sapiens)
• Inflammatory Pain: The Cellular Basis of Heat Hyperalgesia (2006, NA)
• Tumor Necrosis Factor by Microbial Pathogens (2006, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,Human papillomavirus type 16,Human gammaherpesvirus 8,Vaccinia virus,Human T-cell leukemia virus type I,Enterovirus C,Coxsackievirus B3,Murid betaherpesvirus 1,Reovirus sp.,Myxoma virus,African swine fever virus,Cowpox virus,Ectromelia virus,Equine infectious anemia virus,Bovine leukemia virus,Rabbit fibroma virus,Yaba monkey tumor virus,Tanapox virus,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Chlamydia trachomatis,Francisella tularensis,Mycobacterium avium,Neisseria gonorrhoeae,Yersinia pestis,Yersinia enterocolitica,Escherichia coli K1,Brucella suis,Bartonella henselae,Plasmodium falciparum,Trypanosoma cruzi,Leishmania major,Trichinella spiralis,Theileria parva,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,NA,NA,NA)
• Proposed tentative mechanism underlying MAFA-mediated selective inhibition of FcɛRI-induced cytokine gene transcription (2006, NA)
• Local NMDA receptor-mediated Ca2+signaling in CaMKII translocation (2006, Mus musculus,Homo sapiens)
• Physiological Functions of Caspases Beyond Cell Death (2006, NA)
• Interaction between insulin and peginterferon alpha signalling pathway (2006, Homo sapiens,NA)
• The intestinal mucosal barrier is maintained by a series of lateral membrane specialisations near the apical pole of the epithelial cell (2006, NA)
• Model linking HSP70 induction to p33ING1b-induced apoptosis (2006, Homo sapiens)
• PKR is an intermediary component in TLR signaling (2006, NA)
• Two branches of the class I PI3K pathway (2006, NA)
• Proposed signaling pathway for VEGF-induced LIMK1 activation and cofilin phosphorylation (2006, Homo sapiens)
• Intracellular signalling pathways activated by leptin (2006, NA)
• Intracellular signalling pathways activated by leptin (2006, NA)
• Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies (2006, NA)
• Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling (2006, Homo sapiens)
• Working hypothesis (2006, Mus musculus,Oryctolagus cuniculus,Homo sapiens)
• Integration of lipid metabolic and inflammatory signaling in macrophages by LXRs (2006, NA)
• MAPK signaling pathway mapping (2006, NA)
• The pheromone signaling pathway (2006, NA)
• Petri net model of the mating pheromone response pathway of S (2006, Saccharomyces cerevisiae,Solanum tuberosum,Homo sapiens,Escherichia coli)
• Integration of gene expression with the proposed mechanistic pathway initiated by comfrey treatment leading to tumorigenesis (2006, Symphytum officinale,Homo sapiens)
• Effect of HRG stimulation versus EGF stimulation in high HER2-expressing cells (2006, Homo sapiens,Mus musculus,Bos taurus)
• Effect of increased HER2 expression on phosphorylation sites within the EGFR signaling network (2006, Homo sapiens,Mus musculus,Bos taurus)
• Activation of the Akt pathway through binding of a ligand to a receptor, tyrosine kinase (2006, NA)
• Graphical representation of the systems level response in Halobacterium NRC-1 to direct and indirect effects of G radiation showing both repair and oxidative strategies for cell recovery (2006, NA)
• Flux map of the methanogenic pathway for growth of an mtr mutant on methanol and acetate (2006, Methanosarcina barkeri,Homo sapiens)
• An SBGN process diagram (A) and a molecular interaction map (B) of a signaling pathway triggered by ligand binding to EGFR molecules (2006, NA)
• (B) The bow-tie architecture also exists at the signal transduction level (2006, Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Clostridioides difficile,Enterococcus faecalis,Bacteroides thetaiotaomicron,Clostridioides difficile CD3,Mycobacterium avium subsp. paratuberculosis,Clostridioides difficile CD8,Bacteroides ovatus,Clostridioides difficile CD86,Fusobacterium varium,Termitoidae,Periplaneta americana,Penaeus merguiensis,Homo sapiens,Mus musculus,metagenome,Musa acuminata)
• Cell cycle model (2006, NA)
• Signalling cascades following activation of a G-protein coupled receptor (GPCR) (2006, Apis mellifera)
• F igure 9.— (2006, NA)
• Model illustrating a role of BRCA1 in the C2/M cell cycle checkpoint (2006, NA)
• Proteins differentially regulated in RCC involved in carbohydrate metabolism are shown overlaid on the glycolysis and gluconeogenesis pathway KEGG #00010 diagram (2006, NA)
• ECM-integrin signalling coordinates with growth factor signalling to regulate efficient axon growth (2006, NA)
• Regulation of the axon cytoskeleton by PI3K signalling (2006, NA)
• Neurotrophin signalling (2006, NA)
• Innate immune response in lung tissue with or without viral mRNA (2006, NA)
• Smad-dependent signaling and Smad-independent BMP signaling originate from distinct endocytic routes of the BMP receptors (2006, Mus musculus,Chlorocebus aethiops,Homo sapiens)
• Schematic summary of the signaling pathway leading to Nanog repression (2006, NA)
• The dynamic interactions between Beta-catenin and Mitf transcriptional activity (2006, NA)
• The role of HBP1 in p38 MAPK-mediated senescence (2006, Homo sapiens)
• Oncogene cooperation in malignant rasV12, scrib−/− tumors (2006, NA)
• Schema of Ang II-induced NFAT activation in cardiac myocytes (2006, NA)
• MRNA expression levels in TGFBeta-treated T84 epithelial cells compared to control cell culture (2006, Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arachis hypogaea,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus,Cyprinus carpio)
• Hypothetical mechanism of action of DA-9601 on TNF-Alpha-induced CCL20 expression in AGS cells (2006, Homo sapiens)
• Flow-mediated integrin suppression (2006, Bos taurus,Homo sapiens)
• MAPK Hog1p Modulates Fps1p-dependent Arsenite Uptake and Tolerance in Yeast (2006, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Methionine-Homocysteine metabolism and related pathways (2006, NA)
• TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling (2006, Mus musculus,Rattus norvegicus,Homo sapiens)
• Relative expression of components in the CaR/p38 MAPK signaling cascade, as determined by QPCR in FA-6 (F) and T3M-4 (T) pancreatic carcinoma cell lines (2006, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Moloney murine leukemia virus)
• Elevated Homocysteine is associated with atherosclerosis (2006, NA)
• Heat shock on apoptosis related pathways (2006, NA)
• Inhibition of canonical Wnt signalling pathway in the absence of Wnt signals (2006, NA)
• Activation of canonical Wnt signalling pathway in the presence of Wnt signals (2006, NA)
• Inhibition of Wnt signalling by a Fz-dependent pathway (2006, NA)
• Proposed molecular model of dietary omega-3 fatty acid interference with IL-1 signaling pathways leading to COX-2 induction in EC (2006, Homo sapiens)
• Hypothetical model showing the function of the BLR complex in carbon sensing (2006, NA)
• Complete figure for the “Calcium and the Dual Signalling Pathway” graphic (2006, NA)
• Cell-signaling networks induced by Pichinde virus infection as analyzed using the Ingenuity pathway analysis knowledge base (2006, NA)
• Regulation of DNA synthesis by Mec1-checkpoint pathway (2006, NA)
• Engineered biodegradation pathway for paraoxon (2006, Pseudomonas putida,Pseudomonas sp.)
• Outline of the TLR signalling pathway (2006, Homo sapiens,Saccharomyces cerevisiae)
• Three possible examples of tumor-specific targeting using E1A fusion proteins (2006, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Saccharomyces cerevisiae VR1,Adenoviridae,Human adenovirus 5,Homo sapiens,Mus musculus,vectors)
• Regulation of insulin pathway phenotypes by AKT-1 and PDK-1 activation (2006, NA)
• Model of RNF11 interactions in the TGFB receptor signaling pathway (2006, Homo sapiens)
• HIF-dependent VHL pathways in oncogenesis (2006, NA)
• Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance (2006, NA)
• SUMO modification pathway (2006, NA)
• Phosphatidylinositide 3′-OH kinase/Akt/mTOR signaling pathway (2006, NA)
• TGFB signaling pathway (2006, Homo sapiens,Mus musculus)
• Pathway for the assembly of the repeating unit of EPS I in S (2006, Escherichia coli,Agrobacterium tumefaciens,Sinorhizobium meliloti,Bradyrhizobium japonicum,Rhizobium leguminosarum,Mesorhizobium loti,Rhizobium etli,Sinorhizobium meliloti 1021,Rhizobium leguminosarum bv. viciae,Sinorhizobium fredii,Rhizobium leguminosarum bv. trifolii,Rhizobium tropici,Sinorhizobium fredii NGR234,Azorhizobium caulinodans,Rhizobium phaseoli,Rhizobium leguminosarum bv. phaseoli,Sinorhizobium meliloti Rm41,Sym plasmid,Rhizobium etli bv. phaseoli,Sphingomonas sp. S88,Saccharomyces cerevisiae,Glycine max,Pisum sativum,Medicago sativa,Trifolium pratense,Vicia sativa,Vicia sativa subsp. nigra,Erysiphe trifolii,Homo sapiens)
• Cholinergic anti-inflammatory pathway (2006, NA)
• Immunological regulatory IL-10 and MAP kinase pathways (2006, NA)
• Presymptomatic and symptomatic infections including the inflammatory cytokines TNFA, IFNG, and ILB (2006, NA)
• Most probable 3OC12-HSL signaling pathway (2006, NA)
• An altered balance of proapoptotic and antiapoptotic molecules in trauma patients' T cells could indicate specifically increased vulnerability to apoptotic depletion (2006, NA)
• TNFA signaling pathway leading to apoptosis or proliferation of the cells (2006, NA)
• Cellular regulation of Sphingosine-1-Phosphate (S1P) and Prohibitin (2006, Drosophila melanogaster,Plasmodium falciparum,Acropora millepora,Actiniaria,Theileria annulata,Montipora digitata,Anthopleura elegantissima,Plesiastrea versipora,Anemonia viridis,Sarcocystis muris,Solanum lycopersicum,Candida dubliniensis,PX clade,Crypthecodinium cohnii,Symbiodinium microadriaticum,Symbiodinium sp. muscatinei,Mus musculus,Rattus norvegicus,Homo sapiens,Pseudomonas syringae,Bacteriophage sp.,NA,NA)
• Semaphorin 4D activates the MAPK pathway downstream of plexin-B1 (2006, NA)
• Signaling Network for Patterning of Neuronal Connectivity in the Drosophila Brain (2006, Saccharomyces cerevisiae,Diaporthe sclerotioides,Matthiola incana,Homo sapiens,Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Capra hircus,Papio anubis,Mus musculus,Xenopus laevis,NA)
• MAPK signaling pathways (2006, Homo sapiens,Saccharomyces cerevisiae,Simian retrovirus 2)
• GLP-2 stimulation of the Gs-Coupled Receptor induced cell proliferation (2006, Homo sapiens)
• Genes enriched in the VS (shaded) are contained in the canonical pathway for Ras/MAPK signaling (2006, NA)
• Possible involvement of PLDζ1/2 in the PC hydrolysis and DGDG accumulation during phosphorus starvation (2006, Arabidopsis thaliana)
• Cdc42 regulates HF differentiation and cell–cell contacts in keratinocytes by modulating the turnover of Beta-catenin and plakoglobin (2006, NA)
• TSH–cAMP signaling pathway in thyrocytes and its negative feedback regulators (2006, Homo sapiens)
• Cross-talk between the NFKB and the STAT3 pathways (2006, NA)
• Activation of PI3K signaling by PV (2006, NA)
• Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability (2006, NA)
• The signaling pathway regulating the expressions of SMAlpha-actin, SM-MHC, and calponin in SMCs on polymerized collagen in response to PDGF-BB/IL-1B costimulation (2006, NA)
• Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids (2006, Homo sapiens)
• Proposed model for interferon-induced senescence (2006, NA)
• Regulation of AMPAR trafficking by signaling cascades (2006, NA)
• Activation of NFKB via the classical and the alternative pathway (2006, NA)
• The proposed TGFB1 signaling mechanism that promotes EMT (2006, Canis lupus familiaris,Homo sapiens)
• Predicting Essential Components of Signal Transduction Networks: A Dynamic Model of Guard Cell Abscisic Acid Signaling (2006, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Glycine max,Hordeum vulgare,Spinacia oleracea,Saccharum officinarum,Vicia faba,Vicia faba var. minor,Commelina communis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Escherichia coli)
• Impact of SV40 ST on the Notch, Wnt, and Hedgehog Pathways (2006, Middle East respiratory syndrome-related coronavirus,Betapolyomavirus macacae,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Proposed LITAF signaling pathway (2006, NA)
• GSH metabolic pathway (2006, Homo sapiens)
• Ordering and correlation network diagrams for the significant pathways (2006, NA)
• Molecular control of alveolar morphogenesis (2006, NA)
• Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells (2006, NA)
• You say estren, I say estrogen. Let’s call the whole replacement off! (2006, Mus musculus,Homo sapiens)
• RANTES/CCL5 signalling cascade mediated via the novel chemokine receptor, GPR75 (2006, NA)
• Transcript expression of BMP signaling pathway members (2006, Homo sapiens,Mus musculus,Bos taurus)
• Macrophage migration inhibitory factor: controller of systemic inflammation (2006, NA)
• The role of EIN5 in the ethylene signal transduction pathway (2006, NA)
• Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells (2006, NA)
• Comparison of results with the known response pathway (2006, NA)
• Proposed signaling pathways of MAO- A and R1-mediated apoptosis in the human neuroblastoma SK-N-BE(2)-C cells (2006, NA)
• Cytokine release in RAW 264.7 macrophages (2006, Human T-cell leukemia virus type I,Betapolyomavirus macacae,Homo sapiens,Mus musculus,Trichosporon asahii)
• Expression data analysis and visualization on the PANTHER website (2006, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Canis lupus familiaris)
• Combined network of signaling components required for the production of cytokines (2006, Human T-cell leukemia virus type I,Betapolyomavirus macacae,Homo sapiens,Mus musculus,Trichosporon asahii)
• Matrix Formalism to Describe Functional States of Transcriptional Regulatory Systems (2006, Escherichia coli,Helicobacter pylori,Bacillus subtilis,Escherichia coli K-12,Homo sapiens,Saccharomyces cerevisiae,Paracentrotus lividus)
• Matrix Formalism to Describe Functional States of Transcriptional Regulatory Systems (2006, Escherichia coli,Helicobacter pylori,Bacillus subtilis,Escherichia coli K-12,Homo sapiens,Saccharomyces cerevisiae,Paracentrotus lividus)
• Wnt/Beta-catenin signaling pathway (2006, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Protobothrops flavoviridis)
• P38 mitogen-activated protein kinase (MAPK) signaling cascade in T cells (2006, NA)
• Innate model of lupus pathogenesis: central role of TLR-activated MZ-B cells and pDCs (2006, NA)
• PGE2-EP receptor signaling pathways (2006, Mus musculus,Homo sapiens)
• Hypothetical model for HHT (2006, NA)
• Diagram depicting the mechanism by which NGF may inhibit GSK-3B and promote axon growth (2006, NA)
• Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools (2006, Saccharomyces cerevisiae,Homo sapiens)
• Graphical Interface for the KnowledgeNet of candidate genes for hypertension (2006, NA)
• Involvement of MACF1 in the Wnt/Beta-catenin signaling pathway (2006, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathway diagram of genes tested for association (2006, NA)
• Regulation of the FOXM1 transcription factor by the estrogen receptor A at the protein level, in breast cancer (2006, NA)
• Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease (2006, NA)
• Model diagrams indicating regulation and function of E47 activity (2006, NA)
• Proposed model for the action of Cry toxin (2006, NA)
• Network modeling (2006, Homo sapiens,Mus musculus)
• Alternative Th network (2006, NA)
• Hoxc8-regulated transcriptional network in vivo (2006, Mus musculus,Homo sapiens)
• Alternative Th network (2006, NA)
• Different pathways involved in apoptosis (2006, NA)
• CDC maturation upon virus infection (2006, NA)
• Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound (2006, Saccharomyces cerevisiae,Diaporthe sclerotioides,Matthiola incana,Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus,Caenorhabditis elegans,vectors)
• In vitro keratinocyte mitosis (2006, NA)
• Integrated view of regulatory pathways involved in cell wall biology (2006, Saccharomyces cerevisiae,Homo sapiens)
• Regulation of cell wall gene expression during the cell cycle (A) and in response to external stimuli (B) (2006, Saccharomyces cerevisiae,Homo sapiens)
• Hypothetical model describing the roles of Rad18 and PolK in the BPDE-induced S-phase checkpoint (2006, NA)
• Real time pathway analysis of cell-cycle related genes mediated via TS overexpression in HCT-C18 (TS+) cells using actual gene expression data (2006, NA)
• Proposed model of Dexras1 in modulating photic responsiveness of the circadian clock (2006, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• The promotion of neuronal development by CD47 (2006, NA)
• AKT-1/PKB Signaling (2006, Escherichia coli,Escherichia coli 27A,Escherichia coli HT115,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Gallus gallus)
• The BDNF-CREB cascade in the ventral tegmental area (VTA) – nucleus accumbens (NAc) pathway (2006, NA)
• Intracellular signaling pathways downstream of p75NTR and TrkA in sensory neurons (2006, NA)
• Liver X receptor opens a new gateway to StAR and to steroid hormones (2006, NA)
• Signaling cascades in axon specification (2006, NA)
• Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony (2006, NA)
• ET signaling and degradation of EIN3 by 26 proteasome (2006, Arabidopsis thaliana,Solanum lycopersicum,Embryophyta)
• Update schematic diagram of the ET signaling pathway (2006, Arabidopsis thaliana,Solanum lycopersicum,Embryophyta)
• Estrogen mechanisms of action that lead to neurotrophic and neuroprotective outcomes (2006, Homo sapiens)
• Peculiar structure of the juxtanuclear actin network (2006, Adenoviridae,unidentified adenovirus,Homo sapiens)
• CREB cascade (2006, NA)
• PI3K action in chemoattractant signaling to ACA (2006, NA)
• Conservation of the NFKB signaling pathway from horseshoe crab to human (2006, Drosophila melanogaster,Caenorhabditis elegans,Carcinoscorpius rotundicauda,Homo sapiens,Pseudomonas aeruginosa)
• Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond (2006, NA)
• Proposed model for the intersection of innate and adaptive immunity during polysaccharide-induced abscess formation in the peritoneal cavity (2006, Escherichia coli,Streptococcus pneumoniae,Bacteroides fragilis,Homo sapiens,Mus musculus,Drosophila melanogaster,Eleutherococcus senticosus)
• Mammalian target of rapamycin (mTOR) signalling cascade (2006, Homo sapiens,Dipturus trachyderma)
• Role of caveolin-1 in the regulation of the vascular shear stress response (2006, Mus musculus,Homo sapiens)
• Receptor heterodimerization (2006, NA)
• Schematic model of mammalian heme homeostasis (2006, NA)
• GenMAPP growth hormone (Gh) signaling pathway (2006, NA)
• EDA signaling in hair follicle development (2006, Homo sapiens,Mus musculus)
• Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity (2006, NA)
• Metabolic pathway and bioenergetics of net citrate production in prostate cells (2006, Homo sapiens,Rattus norvegicus)
• Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response (2006, NA)
• A negative feedback signaling network underlies oncogene-induced senescence (2006, NA)
• The interaction between activated MEK and the suppression of PKR function during viral infection of tumor cells by ΔG134.5 mutant viruses (2006, Homo sapiens,Chlorocebus aethiops,Mus musculus,Human alphaherpesvirus 1)
• The synaptic signaling network (2006, NA)
• Alternative models for the function of presynaptic UNC-31 (CAPS) (2006, NA)
• The molecular pathways controlling AB generation during aging (2006, NA)
• Schematic overview of the Saccharomyces cerevisiae central carbon metabolism (2005, Saccharomyces cerevisiae,Homo sapiens)
• Novel Jun-Dmp1 pathway (2005, NA)
• Alignment of sequences adjacent to Y200 for human TRPV1–4 (2005, Mus musculus,Homo sapiens)
• Models for ECT-2 activation and its role in activating the EGFR/RAS/MAPK pathway (2005, Caenorhabditis elegans,Homo sapiens)
• Model on Bcr effects on Beta-catenin (2005, NA)
• MAPK pathway in papillary thyroid carcinogenesis (2005, NA)
• MAPK pathway (2005, NA)
• HGF induced cellular responses in endothelial cells (2005, Homo sapiens,Rattus norvegicus)
• CellDesigner () diagram of the insulin/IGF receptor signaling pathway (2005, NA)
• Transforming Growth FactorB Promotes Pro-fibrotic Behavior by Serosal Fibroblasts via PKC and ERK1/2 Mitogen Activated Protein Kinase Cell Signaling (2005, NA)
• Genmapp view of the epidermal growth factor (EGF) signaling pathway (2005, NA)
• The inhibition of Myt1 in the meiotic and mitotic cell cycles in Xenopus (2005, Xenopus laevis,Homo sapiens)
• F igure 7.— (2005, Caenorhabditis elegans,Homo sapiens)
• Mutations That Rescue the Paralysis of Caenorhabditis elegans ric-8 (Synembryn) Mutants Activate the GAs Pathway (2005, Caenorhabditis elegans,Homo sapiens)
• F igure 3.— (2005, NA)
• Fz activation in PCP and Arm signaling (2005, Drosophila melanogaster,Homo sapiens)
• Ingenuity® Pathways Analysis reveals a possible network of genes activated in IEC-6 cells upon induction of the ephrin-B pathway (2005, Rattus norvegicus,Homo sapiens)
• WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability (2005, NA)
• EGFR and mTOR signaling network, and signaling mediator effects associated with rapamycin and/or EKI-785 treatments (2005, Homo sapiens)
• The calcineurin-NFAT and MEK1-ERK1/2 signaling module (2005, NA)
• Intracellular Ca2+ cycling and associated signaling pathway in cardiomyocytes (2005, NA)
• Activation of PI3K/Akt signaling in adaptive versus maladaptive hypertrophy (2005, NA)
• Gq/11-activated pathways in maladaptive hypertrophy (2005, NA)
• GSK-3 as a convergence point in hypertrophic signaling (2005, NA)
• PGC-1A is an integrator of the transcriptional network regulating mitochondrial biogenesis and function (2005, NA)
• Possible negative feedback effects of estrogen-activated cAMP-PKA (protein kinase A) pathway on the estrogen-activated Ras-Raf-MAPK (mitogen-activated protein kinase) pathway of cell proliferation (2005, Homo sapiens,Rattus norvegicus,Bos taurus,Armoracia rusticana)
• Toll-like receptor (TLR) signaling pathways (2005, Drosophila melanogaster,Trypanosoma cruzi,Homo sapiens,Mus musculus)
• Effect of NS5A on the Beta-catenin signaling pathway (2005, NA)
• Exercise and Health: Can Biotechnology Confer Similar Benefits? (2005, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Pathway of circadian regulatory system of Arabidopsis thaliana according to the dynamic regulatory modeling in Table 1 (2005, Arabidopsis thaliana,Homo sapiens)
• Neuroplasticity and cellular resilience in mood disorders; the multiple influences on neuroplasticity and cellular resilience in mood disorders (2005, Nicotiana tabacum,Hypericum perforatum,Homo sapiens,Simian endogenous retrovirus,Pollachius virens)
• Pathway of circadian regulatory system of Arabidopsis thaliana in Fig (2005, Arabidopsis thaliana,Homo sapiens)
• Different types of regulatory T cells (2005, NA)
• Proposed model to illustrate the potential role of neuronal RyR as coincidence detectors of a simultaneous increase in [Ca2+] and ROS/RNS (2005, NA)
• Retinoic Acid and Arsenic for Treating Acute Promyelocytic Leukemia (2005, NA)
• A proposed model for cellular effects of fenugreek seed extract on glucose homeostasis (2005, Homo sapiens,Mus musculus,Trigonella foenum-graecum)
• The mTOR pathway and the potential intersection with LMP2A-activated PI3-kinase/Akt signaling (2005, NA)
• TWEAK-Fn14 signaling system may play a role in stroke pathophysiology (2005, Mus musculus,Homo sapiens)
• TSC1/TSC2 in the canonical Beta-catenin signaling pathway (2005, NA)
• Erk- and PI3K-Akt-dependent cascades regulating mTOR signaling (2005, Homo sapiens)
• Proposed pathway mediating protein overload-induced ET-1 expression (2005, NA)
• Gene Expression Changes during the Development of Acute Lung Injury Role of Transforming Growth Factor B (2005, Mus musculus,Homo sapiens)
• Signaling pathway of NGF-induced neurite outgrowth in PC12 cells (2005, Rattus norvegicus,Homo sapiens)
• Proposed model for differential regulation of the HOG pathway in C (2005, Cryptococcus neoformans,Homo sapiens)
• Generalized insulin signal transduction pathways (2005, Plasmodium falciparum,Anopheles stephensi,Homo sapiens)
• IRAK1 functions in the TLR and IL-1B pathway upstream of convergence with the TNFA pathway (2005, Pseudomonas aeruginosa,Homo sapiens)
• The secretory pathway and UPR under different conditions (2005, Aspergillus nidulans)
• Schematic depiction of the S (2005, NA)
• Schematic view of the proposed pathway of carbohydrates and amino acids in growing embryos (2005, Vicia narbonensis)
• Topologies of the three networks (2005, NA)
• Outlines of the pathways studied (2005, NA)
• Illustration of the Rel/NFKB pathway (2005, NA)
• An example of an AraCyc pathway (2005, Arabidopsis thaliana)
• EGFR Pathway Map (2005, Mus musculus,Rattus norvegicus,Corynephage beta,Corynebacterium phage gamma,Homo sapiens,Bos taurus,Drosophila melanogaster)
• Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others? (2005, NA)
• High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts (2005, NA)
• High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts (2005, NA)
• The central carbon metabolism of E (2005, NA)
• Signaling model for hypoxic activation of HIF-1 (2005, Homo sapiens,Mus musculus)
• Proposed model of Tiam1 and IRSp53 signaling (2005, Mus musculus,Rattus norvegicus,Homo sapiens)
• Models for the action of the Nck/Dock signaling pathways in R-cell growth cones (2005, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Regulation of G1/S transition by the E2F/pRb pathway (2005, Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Schematic diagram for the Notch signaling pathway (2005, Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Human immunodeficiency virus 2,Homo sapiens,Drosophila melanogaster,Paraechinus aethiopicus)
• Schematic diagram for the Wnt signaling pathway (2005, Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Human immunodeficiency virus 2,Homo sapiens,Drosophila melanogaster,Paraechinus aethiopicus)
• Hormone, cytokine, and growth factor mediated signalling to regulate HIF-1A protein expression and transcriptional transactivation activity (2005, NA)
• Cardiac glycosides inhibit TNFA/NFKB signaling by blocking recruitment of TRADD to the TNFR (2005, NA)
• Role of nNOS in TDS stress (2005, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling cascades activated by glutamate NMDA/AMPA and mGlu receptors (2005, Mus musculus,Homo sapiens)
• Schematic model depicting assembly of the Atg1 kinase complex (2005, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Comparison of the D (2005, NA)
• Signalling footprints of the TNF/TNF-R superfamily (2005, NA)
• Organisation of MAP kinase cascades (2005, NA)
• The regulation of replication-dependent histone H4 genes at the G1/S phase cell cycle transition via the cyclin E/CDK2/p220/HiNF-P pathway relative to the E2F/pRB pathway (2005, NA)
• Axin in Wnt signalling (2005, NA)
• Metabolic reconstructions of the polyamine pathway based upon pam and sam analyses of poor-prognosis human NE tumors (2005, NA)
• Bone Morphogenetic Protein Receptor Type II C-Terminus Interacts with c-Src (2005, NA)
• Model depicting how inner ear polarity is generated in response to extracellular signals (2005, NA)
• TAp63Alpha-induced apoptosis (2005, NA)
• Proposed model to explain the mechanism by which the MECT1-MAML2 fusion protein constitutively activates the CREB pathway (2005, Homo sapiens)
• Regulation of lipopolysaccharide (LPS) signaling by suppressor of cytokine signaling 1 (SOCS1) (2005, NA)
• Pathogenesis of sepsis: endotoxin signalling pathway (2005, Homo sapiens)
• Prostaglandin E2 (PGE2) biosynthetic pathway (2005, NA)
• NFKB pathway regulates inflammation, dendritic cell (DC) development and function, and thymic selection and regulatory T cell production (2005, NA)
• Death receptor mediated (extrinsic) pathway of apoptosis (2005, NA)
• P53 pathway (2005, JC polyomavirus)
• Diagrammatic indication of the cytokines, transcription factors, and signalling molecules which polarise virgin CD4 cells into T helper cell type I cells (2005, NA)
• Tumour necrosis factor related apoptosis inducing ligand (TRAIL) receptor signalling (2005, NA)
• Regulatory network of stress responses to drought, salt, and cold: specificity and cross-talk (2005, NA)
• Crosstalk model of ATF3 and c-myc in serum induction (2005, NA)
• Pathways of apoptosis (2005, NA)
• Signal transduction of TNFRI (2005, NA)
• D1 and D2 dopamine receptor signaling pathways (2005, NA)
• Schematic depiction of the crosstalk between different phosphodiesterases (PDE) and the effects of PDE inhibitors on cGMP and cAMP signaling (2005, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Ovis aries,Homo sapiens)
• Innate Immunity in the Lungs (2005, Homo sapiens,Oryctolagus cuniculus)
• Apoptosis and Epithelial Injury in the Lungs (2005, Homo sapiens)
• The Notch pathway in ovarian carcinomas and adenomas (2005, NA)
• Apoptosis and Epithelial Injury in the Lungs (2005, Homo sapiens)
• Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin (2005, NA)
• Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin (2005, NA)
• Pathway-analyses based on decreased (green) and increased (red) genes detected in fibrosarcoma cells after 24 h treatment with doxorubicin (2005, NA)
• Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) (2005, NA)
• Proposed model for regulation of collagen formation in these experiments (2005, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens)
• Interferon-Gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes (2005, Homo sapiens)
• Glucocorticoid Receptor-Dependent Gene Regulatory Networks (2005, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Eucalyptus intertexta,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• CdGAP mediates cross talk between the Ras/MAPK pathway and the regulation of Rac1 activity (2005, Homo sapiens,Chlorocebus aethiops,Mus musculus)
• Comparative Genomics of Natural Killer Cell Receptor Gene Clusters (2005, NA)
• The putative signaling cascades mediating G2/M cell cycle arrest induced by Vpr protein (2005, NA)
• RSV binding and triggering of cellular responses (2005, Homo sapiens,Mus musculus,Bos taurus,Respiratory syncytial virus)
• AB-crystallin against calcimycin-induced apoptosis and the partial explanation why the ocular lens lacks spontaneous tumor (2005, NA)
• Several signaling pathways converge to drive actin polarization (2005, NA)
• Mechanism of TgHSP70 tolerance in PMs from WT mice (2005, Toxoplasma gondii)
• Anandamide as an intracellular messenger inducing Ca2+ influx via TRPV1 (2005, Rattus norvegicus,Homo sapiens)
• EGFR/MAPK/ERK1/2 signaling pathway (2005, NA)
• Schematic model for the chemokine responses of microglia to RV infection (2005, NA)
• Possible gene regulation in macrophage THP-1 stimulated by theophylline (2005, Homo sapiens,Mus musculus,Candida dubliniensis)
• Schematic model depicting potential mechanism that might contribute to epithelial-specific regulation of the CFTR gene (2005, NA)
• General model for murine embryonic Nkx2-5 transcriptional regulation (2005, Mus musculus,Homo sapiens)
• Knockdown of Smad4 affects only a subset of TGF-Beta-regulated target genes and functions (2005, Homo sapiens)
• Possible ATM pathways contributing to polyomavirus replication (see Discussion) (2005, NA)
• PI3-K activity and Nrf2/ARE-mediated phase 2 response (2005, Homo sapiens)
• Caspase signaling and its modulation (2005, NA)
• IKK/NFKB signaling pathways (2005, NA)
• Molecular mechanisms of autophagy (2005, NA)
• Vital Elements of the Wnt-Frizzled Signaling Pathway in the Nervous System (2005, Mus musculus,Homo sapiens)
• Vital Elements of the Wnt-Frizzled Signaling Pathway in the Nervous System (2005, Mus musculus,Homo sapiens)
• Ethylene Signal Transduction (2005, NA)
• Regulation of the extrinsic pathway by Hsps (2005, NA)
• Canonical heterotrimeric and atypical G protein signaling in budding yeast (2005, Saccharomyces cerevisiae,Homo sapiens)
• Wnt-NLK pathway inhibits the activity of Myb family of proteins by two different mechanisms (2005, NA)
• Antiapoptotic molecules regulate the sensitivity to apoptotic signals (2005, NA)
• The molecular mechanisms involved in the TGF-Beta-Smad7 signaling pathway resulting in activation of Akt and p38, followed by phosphorylation and inactivation of GSK-3B (2005, Homo sapiens,Chlorocebus aethiops,Mus musculus)
• P38 MAPK pathways in C (2005, Caenorhabditis elegans,Homo sapiens)
• ADMA upon Gene Expression: An Insight into the Pathophysiological Significance of Raised Plasma ADMA (2005, NA)
• Key components of the canonical Wnt/Beta-catenin signaling pathway (2005, NA)
• Working model of the signaling pathways involved in the radiation-induced bystander effect (2005, NA)
• F igure 4 (2005, NA)
• Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion (2005, Helicobacter pylori,Homo sapiens)
• Activation of the vagus nerve leads to the release of acetylcholine (Ach) that binds to Alpha-7 nicotinic receptors (A7 nAChR) on cytokine producing cells (2005, NA)
• Our model for the mechanism of anti-CD63 inhibition (2005, Mus musculus,Rattus norvegicus,Homo sapiens,Antarctothoa delta)
• Major signaling pathways for type I IFN gene transcription (2005, NA)
• Taxotere and Furtulon on cell cycle, apoptosis, and other pathway related gene expression analyzed and visualized by GenMAPP software integrated with cDNA microarray data (2005, Homo sapiens,Bos taurus,Drosophila melanogaster,Taxus baccata)
• The CycD/Cdk4–mRpL12–Hph pathway (2005, Drosophila melanogaster,Homo sapiens)
• The physiological role of Frat (2005, NA)
• Fibronectin-related signaling pathway graph stored in HBVPathDB (2005, Hepatitis B virus)
• Mevalonate pathway (2005, NA)
• 5-Fluorouracil drug pathway demonstrating the interaction of multiple gene products (2005, Homo sapiens)
• The control of cell migration by integrin-specific regulation of Rho GTPases (2005, Homo sapiens,Mus musculus)
• Invadopodium formation (2005, NA)
• Shared MAPK cascade components signal to three distinct endpoints (2005, Saccharomyces cerevisiae,Homo sapiens)
• Intracellular Calcium Disturbances Induced by Arsenic and Its Methylated Derivatives in Relation to Genomic Damage and Apoptosis Induction (2005, NA)
• Endocrine regulation of the testis (2005, Mus musculus,Rattus norvegicus,Anguilla japonica,Micropogonias undulatus,Homo sapiens)
• Receptor-proximal differences in A4B1 and A5B1 signaling events promoting p130Cas phosphorylation associated with Rac activation in migrating cells (2005, Homo sapiens,Mus musculus)
• An integrated model of signal transduction via the AT1R and resultant physiologic effects within the cardiovascular system (2005, Mus musculus,Homo sapiens)
• The purine nucleotide synthesis pathway in yeast (2005, NA)
• ACTH-induced hypertension by means of the cardiac glycoside binding site of the Na,K-ATPase (2005, NA)
• Model schema for the phosphorylation of CRMP-2 by Rho kinase, Cdk5, and GSK-3B (2005, Mus musculus,Drosophila melanogaster,Gallus gallus,Chlorocebus aethiops,Homo sapiens)
• Putative signaling pathway of the evolutionarily conserved Toll/NFKB pathway utilizing the E (2005, NA)
• Induction of cell death by NO-ASA (2005, Homo sapiens,Mus musculus)
• Possible signal transduction mechanisms generating cAMP in relaxin-stimulated cells (2005, NA)
• Cholesterol in membrane organization during neutrophil polarization and migration (2005, NA)
• Apoptosis mediated by death receptors requires the FADD adaptor molecule (2005, Homo sapiens,Mus musculus,Eucalyptus intertexta)
• Signaling pathways for PDGF-induced proliferation in PSCs (2005, NA)
• The two different benzoate pathways in LB400 (2005, NA)
• Four pathways by which the EBV latent membrane protein 1 (LMP1) is thought to signal inside cells (2005, NA)
• Interaction of the Wnt, BMP, and sclerostin pathways (2005, Mus musculus,Homo sapiens)
• Simplified diagram of the proposed signalling events leading to Cyp7b gene transcription in synovial fibroblasts (2005, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Ubiquitination of key signaling in anergic T cells (2005, NA)
• Systems and molecular complexity in glycobiology (2005, NA)
• Final network resulting from applications of our integration method to the 18 types of evidence for yeast galactose utilization and a set of network analysis tools (2005, Saccharomyces cerevisiae,Homo sapiens)
• The Wnt signal transduction cascade (2005, Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Lareunionomyces loeiensis)
• NO• regulation of the cell cycle (2005, NA)
• Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway (2005, NA)
• Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway (2005, NA)
• Interactive map (pathway) of 46 genes/proteins created in PathwayAssist® from the list of transcripts up-regulated in the testes of ABP-transgenic mice (2005, Mus musculus,Rattus norvegicus,Candida dubliniensis,Sequoia sempervirens,Homo sapiens)
• Acid-sensing pathway in renal proximal tubular cells (2004, NA)
• Proposed model for KAR trafficking in hippocampal neurons (2004, NA)
• Possible signaling pathways controlled by PAMH (2004, Rattus norvegicus,Homo sapiens)
• p35/Cdk5 involvement in RasGRF2 signaling (2004, NA)
• Multiple pathways involved in tumorigenesis by VEGF-null tumor cells (2004, Mus musculus,Homo sapiens)
• ErbB signaling pathway (2004, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Interaction Networks in Yeast Define and Enumerate the Signaling Steps of the Vertebrate Aryl Hydrocarbon Receptor (2004, NA)
• Effect of caloric restriction on energy metabolism translates into longevity (2004, Homo sapiens,Mus musculus)
• Signal transduction pathway in HIF-1A regulation (2004, NA)
• Cholesterol metabolism showing the physiological compartments involved (2004, NA)
• MAPK signaling pathways in Saccharomyces cerevisiae (2004, NA)
• The Function of the Riboflavin Pathway in the JA Signal Transduction Chain.S1 and S2 represent two groups of substrates that are activated by the JA signals (JA) for ubiquitylation and degradation via SCFCOI1-26S proteasome (SCF/COI1) (2004, Arabidopsis thaliana)
• CD14/toll-like receptor 4 (TLR4) intracellular signalling complex (2004, NA)
• Negative regulation of cytokine signalling (2004, NA)
• Cytokine signalling and the pathogenesis of severe combined immunodeficiency (SCID) (2004, NA)
• Type II fatty acid biosynthesis pathway of Bacillus subtilis with mapped transcript correlations RyjaX (same color scale as ) (2004, NA)
• TLR signaling pathways (2004, NA)
• Role of Janus kinases (Jaks) and signal transducers and activators of transcription (STATs) in cytokine signalling (2004, NA)
• F igure 1 (2004, Homo sapiens)
• Changes in transcripts associated with the DNA synthesis pathway (2004, NA)
• Regulation of the mTOR signaling pathway (2004, NA)
• pBimEL escapes sequestration by microtubules and becomes accessible to caspase cleavage (2004, NA)
• Two differing innervation-dependent mechanisms that inhibit myogenin (2004, NA)
• Simplified Model Depicting the Induction of Ethylene Biosynthesis and the Downstream Ethylene Sensing/Signaling Pathway.Ethylene biosynthesis is induced in response to a variety of endogenous and environmental cues (2004, NA)
• Action of TPA to induce apoptosis and inhibition of the AR signalling of LNCaP cells (2004, Homo sapiens,Mus musculus,Armoracia rusticana)
• PC12 cell model of neuronal differentiation (2004, NA)
• Postsynaptic production of nitric oxide implicated in long-term depression at the mature amphibian (Bufo marinus) neuromuscular junction (2004, NA)
• Role of adenosine transport in human umbilical vein endothelium (2004, Homo sapiens)
• Different signalling complexes and subcellular compartmentalisation can generate diverse cellular responses (2004, NA)
• Schematic representation depicting how NTHi and TNFA synergistically activate NFKB as well as the induction of TNFA, IL-1B, and IL-8 in various human epithelial cells, including NHBE cells (2004, NA)
• Development of tamoxifen (TAM)-resistant breast cancer and the changing role of oestradiol (E2) in the life and death of ER-positive cancer cells (2004, NA)
• Schematic description of the apoptotic pathway in PC3 cells treated with DIM (2004, NA)
• Src-induced phosphorylation of FAK coordinates adhesion dynamics, cell migration, survival, and anchorage-independent growth (2004, NA)
• Schematic of the Gp1 mGluR/FMRP pathway (2004, NA)
• Mechanism of endocytic downregulation of RTKs (2004, NA)
• Model of rotavirus-induced diarrhea (2004, NA)
• HDL enhances NO production by eNOS in vascular endothelium (2004, NA)
• F igure 1 (2004, Paracentrotus lividus,Strongylocentrotus purpuratus,Arbacia punctulata)
• IFN-Gamma-inducible CIITA transcription from the type IV promoter is mediated by the Janus Kinase-1/Signal Transducers and Activators of Transcription-1 (JAK-1/STAT-1) signaling pathway (2004, NA)
• Model of the XPAPC signalling pathway (2004, Xenopus laevis,Homo sapiens)
• Schematic presentation showing the possible route of IL-6, IL-8, and IL-13 signaling (2004, NA)
• Interface of the two major molecules implicated in AD pathogenesis with molecular mechanisms of apoptosis (2004, NA)
• Activation of GA9 by cAMP (2004, Dictyostelium discoideum)
• Metabolic flux map of primary and intermediate metabolic pathways in developing soybean cotyledons cultured on Suc (10% [w/w] U-13C) and Gln (2004, Glycine max)
• Functional associations of hypervariable (HV) genes in patients with juvenile rheumatoid arthritis (JRA) (2004, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Corynephage beta)
• Map of major metabolic pathways in M (2004, Methanococcus maripaludis)
• VFLIP effect of cellular survival (2004, NA)
• Repression of pathological cardiac gene expression by CRM1 (2004, NA)
• Examples of extreme signaling pathways of the JAK-STAT signaling network (2004, Homo sapiens)
• Signaling pathway of UCP1 transcription in brown fat (2004, Mus musculus,Homo sapiens)
• Transcriptional organization of the Clostridium acetobutylicum genome (2004, Clostridium acetobutylicum)
• The PI3K–Akt–TSC–TOR pathway and feedback regulation of insulin/IGF-I signaling (2004, NA)
• Differential Roles of Costimulatory Signaling Pathways in Type 1 Diabetes Mellitus (2004, NA)
• Functional associations of genes selected as differentially expressed in patients with juvenile rheumatoid arthritis (JRA) and normal controls (2004, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Corynephage beta)
• Schematic diagram illustrating second messenger pathways possibly involved in regulating pigment granule movement in RPE and entry points for muscarinic regulation (2004, NA)
• Working model of potential mechanisms of DA receptor signaling and sites of action of the different pharmacological agents used in this study (2004, Mus musculus,Homo sapiens)
• Differential Roles of Costimulatory Signaling Pathways in Type 1 Diabetes Mellitus (2004, NA)
• Rapamycin-sensitive TOR signaling in the control of cell growth (2004, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Statins and bacterial infection: model illustrating the effects of statins on S. enterica serovar Typhimurium infection (2004, Mus musculus,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens)
• An outline of the calcineurin signaling pathway (2004, NA)
• Reciprocal regulation of glutathione S-transferase spliceforms and the Drosophila c-Jun N-terminal kinase pathway components (2004, NA)
• Hypothetical scheme of the signaling mechanisms linking M3 and M4 to regulation KC motility and integrin expression (2004, NA)
• Largest connected subgraph resulting from combined query on four pathways involved in carbohydrate metabolism: glycolysis/gluconeogenesis (red); pyruvate metabolism (yellow); TCA cycle (green); and the glyoxylate cycle (pink) (2004, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens)
• Functions of NFKB1 and NFKB2 in immune cell biology (2004, NA)
• GenMAPP of virus-induced gene expression changes affecting integrin subunits, integrin-to-actin signaling pathways, and actin cytoskeleton (2004, NA)
• Vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication (2004, Vaccinia virus)
• N-WASP regulation (2004, NA)
• Models of Notch and polycystin-1 signaling via RIP (2004, NA)
• Molecular events shown by associated predicates (2004, Homo sapiens,Mus musculus)
• Post‐genomic Approach to Understanding Sphingolipid Metabolism in Arabidopsis thaliana (2004, NA)
• Proposed schematic of chemokine-induced traffic and activation of DCs following DNA vaccination with plasmid-encoded Flt3L and MIP-1A (2004, NA)
• MAPK phosphorylation-enhanced Ets-1/Ets-2-CBP/p300 interaction (2004, Homo sapiens,Mus musculus)
• An HIF-1A–Myc pathway regulating hypoxia-responsive genes lacking the canonical HRE (2004, NA)
• Scheme of proposed tumor cell signaling network to control polarity, proliferation, and apoptosis (2004, Mus musculus,Rattus norvegicus,Homo sapiens)
• Innate Immunity in Fruit Flies: A Textbook Example of Genomic Recycling (2004, Drosophila melanogaster,Caenorhabditis elegans,Anopheles gambiae,Homo sapiens,Mus musculus,Alocasia macrorrhizos)
• Summary of the known signaling pathways thought to control aspects of entry into quiescence (2004, NA)
• FGF, Wnt and Tbx3 in epithelial–mesenchymal interactions regulating mammary gland initiation (2004, Homo sapiens,Mus musculus)
• Outline of the Taxol biosynthetic pathway (2004, NA)
• IL-10, IL-22 and IL-22 receptor signalling (2004, NA)
• Signalling cascades of the LPS pathway and reported sites of IL-10 intervention (2004, NA)
• Immune synapse_related signaling pathway and autoimmune diseases (2004, NA)
• Outline of possible scenarios for common mechanisms of pattern recognition of PAMPs and ACAMPs with differential macrophage responses illustrated by the pattern recognition receptor (PRR), CD14 (2004, NA)
• Ca2+-calmodulin-associated signaling elements (2004, NA)
• Schematic model for implication of the cell integrity pathway in the ΔkexB (A) and wild-type (B) strains (2004, Aspergillus oryzae)
• Regulation of angiogenesis by the ancillary receptor endoglin (2004, Mus musculus,Homo sapiens)
• Downstream signaling elements in the cytoplasmic compartment (2004, NA)
• LMP1-induced canonical and noncanonical NFKB activation (2004, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Cascade of transcription factors that induce stress gene expression in response to eIF2A phosphorylation (2004, Mus musculus,Homo sapiens)
• Role of adaptors in T-cell signalling (2004, NA)
• Consensus model of the cell cycle control mechanism in budding yeast (2004, Saccharomyces cerevisiae,Homo sapiens)
• MUC20 suppression (2004, NA)
• Generalized reactions for the JAK-STAT signaling network (2004, Homo sapiens)
• Schematic diagram for the synergistic JNK activation triggered by cross-communication between Gi-coupled receptors and EGF signaling (2004, Chlorocebus aethiops,Homo sapiens)
• Protein interaction map around some selected baits in the TGFB pathway (2004, NA)
• Fas receptor pathway of apoptosis (2004, NA)
• Recapitulative scheme of the pathways analyzed in this study (2004, NA)
• Functional associations of genes identified by discriminant function analysis (DFA) in patients with juvenile rheumatoid arthritis (JRA) who were undergoing treatment (2004, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Corynephage beta)
• BMP4 and LIF signaling in pluripotency (2004, NA)
• Regulation of IGF signaling by p53 (2004, NA)
• Working model for SPRR1A activation in the myocardium (2004, NA)
• Schematic representation of signalling cascades and activation of NFKB and AP-1 (2004, NA)
• Probability flux distributions for human red blood cell (2004, Homo sapiens)
• Anaerobic glycolytic pathway model of nongrowing yeast, S (2004, Saccharomyces cerevisiae,Homo sapiens)
• Mechanisms Underlying Differential D1 versus D2 Dopamine Receptor Regulation of Inhibition in Prefrontal Cortex (2004, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGFB1-induced Erk activation and EMT being blocked by U0126 (2004, Mus musculus,Homo sapiens)
• Intracellular signaling events downstream of the P2Y1 and P2Y12 receptors (2004, NA)
• The multiple mechanisms by which HSV-1 blocks cellular IFN-based defense systems (2004, Human alphaherpesvirus 1,Chlorocebus aethiops,Homo sapiens)
• TRPC3 in calcium-dependent gene regulation in skeletal muscle (2004, Mus musculus,Homo sapiens)
• Action of SHP on negative feedback regulation of CYP7A1 in bile acid signaling (2004, NA)
• Apoptosis: the 'extrinsic' and 'intrinsic' pathways to caspase activation (2004, NA)
• Phospholipid synthesis cascade (2004, NA)
• Cell survival signaling pathways (2004, NA)
• Visualizing protein interaction networks in HPRD (2004, Homo sapiens)
• Will the Real Cholesterol Transporter Please Stand Up (2004, NA)
• FGF signaling pathway in the control of cell migration in Drosophila (2004, NA)
• Trauma-Hemorrhagic Shock Mesenteric Lymph Induces Endothelial Apoptosis That Involves Both Caspase-Dependent and Caspase-Independent Mechanisms (2004, NA)
• The signaling networks involving IAA, NO, and cellular messengers that regulate ARF in cucumber (2004, Cucumis sativus)
• Initial model for the transcription system at RP promoters (2004, NA)
• Heuristic model showing the tyrosine phosphorylation signaling pathways in sperm cell involved in capacitation (2004, NA)
• Simplified model of insulin signaling (2004, NA)
• Schematic diagram depicting the potential steps leading to caspase-3 activation in CNS trauma (2004, Homo sapiens)
• Dependence of different CD95 signalling pathways on a functional DD (2004, Homo sapiens,Mus musculus)
• The role of aPKC in the estradiol-induced signaling complex (2004, NA)
• Mitogenic signals are transduced by Ras which inhibits the retinoblastoma (Rb) protein allowing E2F and Myc to promote cell cycle progression (2004, NA)
• Extrinsic, or death receptor, pathway (see text for details) (2004, NA)
• Intrinsic, or mitochondrial, pathway (after Danial and Korsmeyer) (2004, NA)
• Two models relating Akt and Tsc2 in cell growth control in Drosophila (2004, Drosophila melanogaster,Homo sapiens)
• Simplified diagram of the Wnt/APC pathway (2004, NA)
• Schematic model for the induction of NO and CXCL10 production in macrophages in response to RV virions (2004, NA)
• Overview and comparison of the central intermediate metabolism of the endosymbiotic bacteria (2004, NA)
• Simplified representation of molecular mechanism involved in insulin signaling pathway that regulates glucose transporter (GLUT4) translocation to cell membrane (2004, NA)
• Hormonal Regulation of Plant Growth and Development (2004, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Triticum aestivum,Homo sapiens)
• 5-Fuorouracil drug pathway demonstrating the interaction of multiple gene products (2004, Homo sapiens,Diaporthe sclerotioides)
• Sterol-Derived Hormone(s) Controls Entry into Diapause in Caenorhabditis elegans by Consecutive Activation of DAF-12 and DAF-16 (2004, NA)
• Wiring diagram describing the multiple interactions downstream of FGFR that lead to activation of the Ras/MAPK and PI 3-kinase/Akt signaling pathways (2004, NA)
• The signaling pathways involved in glucocorticoid-mediated enhancement of IL-1Beta-induced TLR2 expression via MKP-1-dependent inhibition of p38 and JNK in human epithelial cells (2004, NA)
• Wnt signaling pathway (2004, NA)
• Proposed framework for continuous recruitment of T cells into the gut mucosa through CD40/CD40L dependent mechanisms (2004, NA)
• Pleiotropic effects resulting from the interaction of activated CD40L+ T cells, activated CD40L+ platelets, or soluble CD40L with immune and non-immune cells (2004, NA)
• CREB pathway and possible positions of proteins whose genes contain CREB1 binding sites (2004, NA)
• Schematic diagram showing the proposed survival mechanism induced by 17-Beta-estradiol (2004, NA)
• Math1 signalling pathway (2004, NA)
• Wnt signalling pathway (2004, NA)
• Role of B-Raf/ERK in regulating Rho-activated pathways leading to actomyosin contraction (2004, Homo sapiens,Mus musculus)
• Spindle assembly and orientation checkpoints in fission yeast (2004, NA)
• Chart of cell cycle genes (2004, NA)
• Schematic drawing of the hypothetical metabolic routes (glycolysis, Krebs, and glyoxylate cycles), modified from Tabak et al (2004, NA)
• Signaling kinases involved in regulation of TNFA, IL-10, and IL-6 in Kupffer cells (2004, Rattus norvegicus,Homo sapiens)
• Schematic model of signaling events to MEKs and Erks induced by threshold concentrations of Epo (2004, NA)
• Mechanisms of effects of ATRA/As2O3 on APL cells (2004, NA)
• The roles of Ras and Mob2 in S (2004, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Signal transduction pathways for Ras/Raf-mediated growth inhibition and differentiation (2003, NA)
• F igure 8 (2003, NA)
• Role of Inp53p and other machinery in trafficking of TGN resident proteins between the TGN and endosomes (2003, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Signal transduction in the Transforming Growth Factor B(TGFB) family pathway is finely regulated at many levels (2003, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Gallus gallus,Xenopus laevis,Anatoecus sp. C,Homo sapiens)
• Proposed pathways for the ExoS-mediated apoptosis (2003, Pseudomonas aeruginosa,Homo sapiens)
• Scheme to illustrate the separate functions and regulation of conventional nonsarcomeric myosin IIA and myosin IIB (2003, NA)
• Hyperphosphorylation of tau caused by the expression of a dominant-negative mutant form of PP2A CA in transgenic mice (2003, NA)
• Possible involvement of MRP5 in the regulation of the function of cardiovascular smooth muscle cells and cardiomyocytes via the NO/cGMP-signaling pathway (2003, NA)
• SPARC-mediated regulation of and coupling to the TGFB signaling system (2003, NA)
• Drosophila Toll pathway (2003, NA)
• Signal transduction model of the EGF receptor signaling pathway (2003, NA)
• Schematic diagram showing our current model for the role of PIP4K II in PI-3,4,5-P3 regulation (2003, Shigella flexneri)
• JNK-dependent apoptosis signaling pathway (2003, NA)
• Pathways involved in sugar fermentation via glycolysis to lactate and/or other acids and biosynthesis of EPS in L (2003, Lactococcus lactis)
• Xu-5-P is the signal for the coordinated control of lipogenesis (2003, Rattus norvegicus,Homo sapiens)
• NEW EMBO MEMBER’S REVIEW (2003, NA)
• NEW EMBO MEMBER’S REVIEW (2003, NA)
• MAPK pathway mediates ethylene signaling in plants (2003, Arabidopsis thaliana)
• p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop (2003, NA)
• Outline of the different mechanisms involved in blood vessel formation (2003, Gallus gallus,Homo sapiens)
• TGFB superfamily signalling pathway (see text for explanation) (2003, Gallus gallus,Homo sapiens)
• Neuroprotective actions of FK506 consists of a calcineurin dependent (right) and of a calcineurin independent pathway (left) (2003, NA)
• Agonist-induced smooth muscle cell contraction (2003, NA)
• AT1 receptor signal transduction pathways that result in transcriptional NA neuromodulation (a) and increased firing rate (b) in neuronal cultures (2003, NA)
• Signaling pathways potentially involved in altered AT1 receptor function and enhanced myogenic reactivity in CHF (2003, Rattus norvegicus,Homo sapiens)
• Proposed mechanism for FK506-potentiated neurite outgrowth (2003, NA)
• Models of the insulin-signaling pathway in Drosophila and regulation of d4E-BP by phosphorylation (2003, Drosophila melanogaster,Homo sapiens)
• Smirnoff-Wheeler AsA biosynthetic pathway (2003, Arabidopsis thaliana,Nicotiana tabacum,Zea mays,Embryophyta,Solanum tuberosum,Hordeum vulgare,Cucumis sativus,Fragaria x ananassa,Nicotiana benthamiana,Spinacia oleracea,Pisum sativum,Medicago sativa,Phaseolus vulgaris,Ipomoea batatas,Brassica rapa,Ricinus communis,Apium graveolens Dulce Group,Brassica rapa subsp. rapa,Cucurbita pepo,Apium graveolens,Cucurbita maxima,Cucurbita moschata,Coleus scutellarioides,Myrciaria dubia,Brassica rapa var. oleifera,Mespilus germanica,Homo sapiens,Rattus norvegicus,Myzus persicae)
• Role of FXR in the suppression of CYP7A1 (2003, NA)
• Chemoresistance in Human Ovarian Cancer Cells (2003, NA)
• Caspase 3 activation is essential for neuroprotection in preconditioning (2003, Rattus norvegicus,Homo sapiens)
• CFTR-EBP50B2AR signaling (2003, NA)
• Signal transduction pathways in the regulation of RNA transcription (broken lines) and splicing (solid lines) (2003, NA)
• Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1 (2003, NA)
• Conservation of the Ral-centered signaling network in mammals and flies (2003, Drosophila melanogaster,Homo sapiens)
• Interaction between the Wnt/Beta-catenin and Wnt/Ca2+ pathways (2003, Mus musculus,Rattus norvegicus,Homo sapiens)
• CRP-dependent (A) and CcpA-dependent (B) carbon catabolite repression pathways and the Ntr regulatory pathway (C) (2003, NA)
• The PI 3-kinase pathway by RNAi (2003, NA)
• BMP signaling pathway (see text for details) (2003, NA)
• FADD-DD–induced apoptosis signaling in normal prostate epithelial cells (2003, NA)
• Highlights of key changes in cell cycle, differentiation, and metabolism-related transcripts (2003, NA)
• Distinct signaling pathways induced by rhTum and rhEndo (2003, Homo sapiens)
• Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway (2003, NA)
• Protein kinase D mediates a stress-induced NFKB activation and survival pathway (2003, Mus musculus,Homo sapiens)
• RelB is required for Peyer’s patch development: differential regulation of p52–RelB by lymphotoxin and TNF (2003, NA)
• Simplified schematic representation of the three well-characterized glucose-response pathways in S (2003, NA)
• Generic schema for the cytokine/adaptor/MAPK signaling paradigm (2003, NA)
• Signalling pathway mediating cardioprotection against myocardial ischemia/reperfusion injury by ethanol consumption (2003, NA)
• Interplay of the major genetic alteration in pancreatic carcinoma with the cell cycle (2003, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Diagram depicting the yeast PKC signaling pathway (2003, Saccharomyces cerevisiae,Homo sapiens)
• Synopsis of the crosstalk between AR and the ErbB cascade (2003, NA)
• The interaction between the AR and the ErbB/MAPK pathway (2003, NA)
• Pathways activated by vGPCR that contribute to the activation of NF-AT (2003, NA)
• Protein degradation through the ubiquitin (Ub)-proteasome pathway (2003, NA)
• Ubiquitin (Ub)-mediated pathways of growth factor receptor (GFR) downregulation (2003, NA)
• Pictorial representation of a Notch protein and its signalling pathways (2003, Human papillomavirus,Mouse mammary tumor virus,Feline leukemia virus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Xenopus laevis,Felis catus)
• Canonic Wnt signaling pathway molecules can induce a similar phenotype (2003, NA)
• Schematic showing the mevalonate pathway (2003, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Dictyostelium discoideum,Cutibacterium acnes)
• Molecules involved in the IL-3 signaling pathways that lead to mcl-1 gene transcription through the SIE and CRE-2 elements (see text for details) (2003, Mus musculus,Homo sapiens)
• Wnt-signaling pathway (2003, NA)
• TLR signaling pathways (2003, NA)
• Cytokine, and interference with the cytokine receptor or signaling pathway (2003, Homo sapiens)
• Neuronal cell death pathways may be divided into necrotic pathways, caspase-independent apoptotic pathway, and caspase-dependent apoptotic pathway (2003, Homo sapiens)
• How integrin-linked kinase (ILK) and glycogen synthase kinase-3B (GSK-3B) might be involved in the acute radiation response with regard to cell survival, cell cycle progression and initiation of G2 phase arrest (2003, NA)
• TGFB signaling in normal colonic epithelium and cancer cells (2003, NA)
• Schematic model of the signal pathway of phot1- and phot2-dependent increase in [Ca2+]c in leaves of A (2003, NA)
• T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression (2003, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,vectors)
• Schematic diagram showing the results of ras activation by Grb2 (2003, NA)
• Free p65 can protect against TNF-Alpha-induced apoptosis in the absence of IKK activity (2003, NA)
• Microarray summary of proteasome subunits induced in mouse liver by D3T (2003, NA)
• Coagulation, fibrinolysis, and angiogenesis in cancer (2003, NA)
• Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts (2003, NA)
• Schematic diagram showing the signaling pathways involved in NTHI-induced IL-8 transcription (2003, NA)
• Regulation of the Foxa and Foxo transcription factors through PI3-kinase signaling (2003, NA)
• TGFB signaling pathway (2003, NA)
• Proposed “synthesis” model for APV molecular pathogenesis in an infected host cell (2003, Mus musculus,Gallus gallus,Avian metapneumovirus,Homo sapiens)
• Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans (2003, Caenorhabditis elegans,Homo sapiens)
• bFGF/AvB3 and VEGF/AvB5 signaling pathways (2003, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Escherichia coli,Gallus gallus,Homo sapiens)
• NFKB signalling pathways in different cell systems (2003, Mus musculus,Homo sapiens)
• MDia in SDF-1A-dependent axon outgrowth in cultured cerebellar granule neurons (2003, NA)
• Recruitment of BMP signals in fate choice decisions (2003, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens)
• Mechanisms leading to neuronal degeneration in hyperglycemia involve reactive oxygen species (ROS) formation (2003, NA)
• Differential regulation of NFAT and SRF by the B cell receptor via a PLCG–Ca2+-dependent pathway (2003, Gallus gallus,Homo sapiens)
• Regulation of bim gene expression by NGF in sympathetic neurons (2003, NA)
• The cyclooxygenase–prostanoid biosynthetic and signalling pathway (2003, NA)
• Possible mechanisms involved in the autocrine–paracrine–intracrine regulation of cyclooxygenase (COX) enzyme expression in epithelial and endothelial cells (2003, NA)
• Multiple roles for kinases in DNA replication (2003, NA)
• Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility (2003, Homo sapiens,Listeria monocytogenes)
• JAK-STAT antiviral defense in the cardiac myocyte and SOCS inhibition to limit early virus-induced cardiac injury (2003, Adeno-associated virus,Enterovirus B,Homo sapiens,Mus musculus)
• Cytotoxic T lymphocyte (CTL) induced apoptosis signalling pathways (2003, NA)
• Activation of the MAPK signaling pathway by FSH, ATP and GnRH in ovarian cancer (2003, NA)
• Putative roles of 5-HT receptor modulation of neuronal properties in Aplysia californica (2003, NA)
• The key proinflammatory pathway induced by enteric pathogens results in nuclear factor kappa B (NFKB) mediated transcription of interleukin 8 (IL-8) (2003, NA)
• Putative interactions between relaxin receptor signaling and intrinsic NO pathway (2003, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Sus scrofa)
• Proposed mechanism of CD4+ T cell priming after Leishmania major infection (2003, NA)
• Pheromone response pathway (2003, NA)
• Estrogen action on PSD-95 new protein synthesis (2003, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular dissection of the signaling cascade underlying BCR-controlled integrin A4B1-mediated adhesion (2003, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Gallus gallus,vectors)
• The FA pathways involved in ABeta-induced neuronal dystrophy (2003, Rattus norvegicus,Homo sapiens)
• Hypoxia-sensing pathway (2003, Homo sapiens)
• Biochemical pathways of TSH and folate metabolism in Leishmania (2003, Leishmania major)
• Cellular model of the rapid signaling of estrogen in hypothalamic neurons (2003, Mus musculus,Cavia porcellus,Homo sapiens)
• Signaling pathways implicating p120-RasGAP (2003, NA)
• Conserved longevity-regulatory pathways in S (2003, Saccharomyces cerevisiae,Homo sapiens)
• Metabolic map showing relative expression ratios (intensity of TF5015 versus that of W3110) of transcript levels in the central metabolic pathway (A) and the threonine biosynthetic pathway (B) (2003, NA)
• Summary of calcium influx- and phosphoinositide 3-kinase (PI 3-kinase)-dependent mechanisms of negative regulation of interleukin (IL)-12 p40 and p35 gene induction (2003, Mus musculus,Acanthocheilonema viteae,Homo sapiens)
• Proximal B-cell receptor-mediated signalling pathways (2003, NA)
• EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer (2003, Homo sapiens,Rattus norvegicus)
• View into an erosion: mechanisms involved in osteoclastogenesis and arthritic bone erosion (2003, NA)
• Osmosensing signal transduction pathway in yeast (2003, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice (2003, Homo sapiens,Mus musculus)
• F igure 10 (2003, NA)
• GPR-mediated initiation of G protein signaling (2003, NA)
• Model depicting the cooperative action of JNK and GSK-3 in regulating the c-Jun stress response in neurons (2003, NA)
• The development, activation, and maintenance of the satellite cell (2003, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Extracellular and intracellular antagonism of BMP signaling by myostatin and TGFB (2003, Mus musculus,Homo sapiens)
• Osteoblasts express components necessary for coordinating mineralization of ECM and phosphate handling by the kidney (2003, Mus musculus,Homo sapiens)
• MAP kinase signalling pathways (2003, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus)
• Hypoxic activation of apoptosis pathways (2003, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus)
• Working model for Smad6 functions in BMP signaling (2003, NA)
• Canonical Wnt/Beta-catenin pathway (2003, NA)
• Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway (2003, NA)
• Selenium compounds in cancer prevention (2003, NA)
• Signaling UPR-mediated cell death (2002, NA)
• The signalling mechanisms involved in histaminic receptor activation (2002, Homo sapiens,Mus musculus)
• Keeping up with calcium (2002, NA)
• Mechanisms and functions of proteasomal targeting of Smad1 in signaling pathways of BMPs.A (2002, NA)
• Cell cycle trials in Salamanca (2002, NA)
• SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans (2002, Caenorhabditis elegans,Homo sapiens)
• Regulatory interactions between SRF and TCF (2002, Mus musculus,Saccharomyces cerevisiae,Cervus elaphus,Homo sapiens)
• UV-induced apoptotic signaling pathway (2002, NA)
• Known Wnt signaling pathways (2002, Gallus gallus,Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Mouse mammary tumor virus)
• Aspects of the mammalian unfolded protein response (UPR) and the component of the pathway that regulates them (2002, Homo sapiens,Mus musculus)
• Interaction of stress and inflammatory responses (2002, NA)
• Cytokine production by MAPK pathways (2002, NA)
• Schematic showing signal transduction pathways mediated by environmental stresses such as lipopolysaccharide (LPS), cytokines, hyperoxia and irradiation (UV) (2002, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Dipturus trachyderma,Hippocampus comes,Homo sapiens,Sus scrofa)
• Model for cell cycle regulation by the PI3K/PKB/Forkhead pathway (2002, Homo sapiens,Mus musculus)
• Cytokine regulation by NFKB pathway and the interaction with stress response (2002, NA)
• Effects of TSP2 and growth factors on cell cycle progression and apoptosis in microvascular ECs (2002, NA)
• The role of retinoid inhibition of rod CNG channels (2002, NA)
• Hh-signaling pathway (2002, NA)
• Hypothetical pathway (solid lines) for glucose dissimilation by triose phosphate isomerase-negative (tpi1Δ) S (2002, NA)
• Biosynthetic scheme proposed for resolvins: aspirin-triggered omega-3-derived products (2002, Glycine max,Diaporthe sclerotioides,Solanum tuberosum,Homo sapiens,Mus musculus)
• The modulation of cellular signaling pathways by NS5A (2002, NA)
• Representation of the cell cycle control pathway within TIGR Orthologous Gene Alignment (TOGA) (2002, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• The yeast glyoxylate bypass pathway and its possible connection with other predicted changes (2002, Saccharomyces cerevisiae,Homo sapiens)
• Scheme of Hsp27-induced effects on apoptosis (2002, NA)
• Up-regulation of RAD51 in 8-MOP-treated cells (2002, NA)
• Ras-dependent regulation of the Schwann cell cycle (2002, Homo sapiens)
• The terminal checkpoint and its regulation by SP85 (2002, Salmonella enterica subsp. enterica serovar Typhimurium,Dictyostelium discoideum)
• Oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of AvB3 integrins (2002, Homo sapiens,Rattus norvegicus)
• slpr, encoding Drosophila MLK, is the MKKK for the Jun kinase pathway during dorsal closure in the fly (2002, NA)
• Proposed intracellular pathways for the induction of NO and PAF synthesis by VEGF in endothelial cells (2002, NA)
• Dual role of Beta-catenin in cell adhesion and transcriptional activation (2002, NA)
• JAK-STAT signaling and the generation of Th1 and Th2 cells (2002, NA)
• Cellular signalling by CpG-DNA (2002, Drosophila melanogaster,Homo sapiens)
• TGFB signaling pathway (2002, NA)
• Conversion of major constituents in the stem cuticular wax biosynthetic pathway (2002, NA)
• The activation of immediate-early genes and the HDAC1 gene by histone H3 phosphoacetylation (2002, NA)
• Survival genes through both an NFKB pathway, as well as through an alternate mechanism (2002, Homo sapiens)
• Furin in development, homeostasis and disease (2002, NA)
• Neuroplasticity and cellular resilience in mood disorders (2002, NA)
• Toward a model of B cell activation through CD40-regulated gene expression (2002, NA)
• SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer (2002, NA)
• Biological actions of isoprenoids and cholesterol (2002, NA)
• Activation of the NFKB pathway by IL-1 (2002, NA)
• Nitric oxide signalling by selective B2-adrenoceptor stimulation prevents ACh-induced inhibition of B2-stimulated Ca2+ current in cat atrial myocytes (2002, NA)
• The organization of cholesterol in the membranes of the sperm head, and its role in signaling (2002, NA)
• Signaling and transcriptional pathways of Th1 differentiation and the potential role of c-Rel (2002, NA)
• Events proposed to cause nephrotoxic ARF (2002, NA)
• Biosynthetic pathway of oxylipins in Arabidopsis (2002, NA)
• Model Showing the Function of AtE2Fc in Relation to Cell Division and Development.Information for AtE2Fa/DPa is adapted from (2002, Arabidopsis thaliana)
• Some of the negative feedback mechanisms discussed at the meeting (2002, NA)
• Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo (2002, Homo sapiens,Drosophila melanogaster)
• Model depicting the Beta-catenin phosphorylation–degradation cascade (2002, NA)
• Mating, osmoresponse, and cross talk pathways (2002, Saccharomyces cerevisiae,Homo sapiens)
• Intrinsic and extrinsic pathways of apoptosis (2002, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Listeria monocytogenes)
• Different telomere damage signaling pathways in human and mouse cells (2002, Homo sapiens,Mus musculus)
• Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals (2002, Mus musculus,Homo sapiens)
• Effect of nitrogen-containing bisphosphonates on the mevalonate pathway by inhibiting farnesylpyrophosphate synthase (2002, Mus musculus,Rattus norvegicus,Homo sapiens)
• Simplified model of some of the components of p53 signalling (2002, NA)
• Failure of endogenous regulation of wound-healing in idiopathic pulmonary fibrosis (IPF) (2002, NA)
• Biochemistry of myosin, the Rho kinase pathway, and maintenance of tone (2002, NA)
• Calcium/calcineurin/NFAT signalling pathway in T cells (2002, Mus musculus,Rattus norvegicus,Homo sapiens,Listeria monocytogenes)
• CEP-1347 blocks cell death, and JNK acts upstream of the divergence of cell death pathways (2002, NA)
• Cross-talk between growth factors and integrins in endothelial cells (2002, NA)
• Prolactin signaling and Stat5 (2002, NA)
• Models for the effects of inactivation versus activation of the Rb pathway (2002, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Mouse mammary tumor virus)
• Proposed model for the roles of Sos-1 in the signaling pathway leading to activation of Rac (2002, NA)
• Models for SPR-1 and SPR-5 function (2002, NA)
• The action of S-phase checkpoints in the suppression of spontaneous genome instability (2002, NA)
• Role of Axin2 in Wnt signal transduction (2002, Mus musculus,Danio rerio,Homo sapiens)
• The interactions between the Gq and Wnt/Beta-catenin signaling pathways (2002, NA)
• Down-regulation of the inflammatory response (2002, NA)
• Selective interference of UVB radiation with the EGFR-dependent signal transduction in keratinocytes (2002, NA)
• Fucosylation pathways in mammals (2002, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Pisum sativum,Aleuria aurantia,Homo sapiens,Escherichia coli)
• Effects of HIC and I-mfa on Axin-mediated signaling (2002, Danio rerio,Xenopus laevis,Homo sapiens)
• Model depicting an indirect pathway linking expression of activated Notch (NotchIC) with the inhibition of E2A (2002, NA)
• The proposed c-Kit signal transduction pathway in PGCs (2002, NA)
• Gelsolin-induced epithelial cell invasion is dependent on Ras–Rac signaling (2002, NA)
• Convergence of multiple intracellular signaling pathways at GSK-3 (2002, NA)
• Biosynthetic pathway of physiological and engineered sialic acid precursors (2002, NA)
• Kv4.2 subunit is the target of MAPK signaling pathway (2002, Rattus norvegicus,Homo sapiens)
• Summary of established Beta-catenin pathways (2002, NA)
• Signalling in osteoclast progenitor cells and cross talk with the interferon pathway (2002, Mus musculus,Homo sapiens)
• Neurotrophins, the ERK MAP kinase signaling cascade, and GSK-3 (2002, NA)
• Fas death signalling pathways (2002, NA)
• Mitochondrial death signalling pathways (2002, NA)
• Role of Beta-catenin in the wingless/Wnt nuclear signaling pathway (2002, Chlamydia trachomatis,Homo sapiens)
• Convergence of signaling pathways (2002, Mus musculus,Homo sapiens)
• Major signaling pathways activated in response to oxidative stress (2002, NA)
• TLR signal transduction pathways (2002, Respiratory syncytial virus,Tobacco mosaic virus,Homo sapiens,Mus musculus,Drosophila melanogaster,Staphylococcus aureus,Melampsora lini)
• AB modulation of PKA/CREB pathway: a working hypothesis (2002, NA)
• ErbB/Ras pathway and Wnt pathway (2002, Mus musculus,Danio rerio,Homo sapiens)
• NEW EMBO MEMBER’S REVIEW (2002, NA)
• Proteins of the sarcomere, cytoskeleton, sarcolemma, and ECM of muscle, which are connected (2001, NA)
• Proposed model for RhoA signaling to the c-jun promoter (2001, Mus musculus,Homo sapiens)
• The NFKB pathway by viruses (2001, NA)
• Proposed mechanisms of NFKB activation in HIV-1–infected cells (2001, NA)
• Biochemistry of NFKB activation (2001, NA)
• Models for the function of Ser307 phosphorylation (2001, NA)
• Interferon Regulatory Factor Expression in Human Breast Cancer (2001, NA)
• Proposed pathway for the induction of EC PAF synthesis by VEGF (2001, Bos taurus,Homo sapiens)
• Schematic model of intracellular signal components that control S-phase entry in vestibular epithelia from neonatal mammals (2001, NA)
• Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF (2001, Homo sapiens,Chlorocebus aethiops)
• The signaling pathways activated by N (2001, NA)
• Apoptotic signaling pathway mediated by NGF withdrawal (2001, Rattus norvegicus,Homo sapiens)
• The trafficking of NMDA receptors at the corticostriatal synapse (2001, NA)
• The B(a)P-induced apoptotic signaling pathway, which is mediated by APIX (2001, NA)
• Sex and sugar in yeast: two distinct GPCR systems (2001, NA)
• Trophic signaling attributable to depolarization: summary diagram (2001, NA)
• Two initiation pathways, triggered by separate events, converge to execute apoptosis (2001, NA)
• Leptin action on the TRH neuron (2001, Rattus norvegicus,Homo sapiens)
• Proposed model for the synergistic effects by MPP+ and caspase inhibition (2001, Mus musculus,Rattus norvegicus,Homo sapiens)
• ABeta-stimulated microglial and monocytic proinflammatory products cause TNFA/iNOS-dependent neuronal apoptosis (2001, NA)
• Biosynthetic pathways to GAs and ent-kaurenoids in G (2001, NA)
• The cellular effects of estrogen in the brain (2001, Rattus norvegicus,Homo sapiens)
• Intracellular vesicle transport pathways and localization of selected Rabs (2001, NA)
• Effect of salicylates on insulin signaling during insulin resistance (2001, NA)
• Relation between some major controlling factors involved in apoptosis (2001, NA)
• Simplified diagram of the canonical Wnt/Beta-catenin signaling pathway (2001, NA)
• Phosphoinositide 3-kinase (PI3K) signalling and cancer (2001, NA)
• The TGFB signaling pathway, showing the activation cascade and points of inhibition (??) (2001, NA)
• Proposed model for Rac1-mediated STAT3 activation (2001, NA)
• IFN signaling by the Jak-Stat pathway (2001, NA)
• Action of ONYX-015 (2001, Adenoviridae)
• Antagonism of the antiviral actions of IFN by viral gene products (2001, NA)
• E1A-induced apoptosis in DNA-damaged HCT116 cells (2001, Homo sapiens,Adenoviridae)
• Proposed signaling pathways that modulate ManLAM-induced iNOS expression (2001, NA)
• Signaling to eukaryotic translation initiation and elongation factors (2001, Saccharomyces cerevisiae,Homo sapiens)
• LPS-induced signaling pathways leading to activation of transcription and spreading (2001, Mus musculus,Homo sapiens)
• Proposed pathways for the cytokine regulation of Baf-3 cell survival (2001, NA)
• Receptor proximal signaling pathway for IL-1 (2001, NA)
• Role of the Rfc4-Rpa1 interaction in DNA replication and DNA damage checkpoint signaling (2001, Saccharomyces cerevisiae,Homo sapiens)
• Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro (2001, NA)
• In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries (2001, NA)
• Adenosine transport by insulin in human umbilical artery smooth muscle cells from normal or gestational diabetic pregnancies (2001, NA)
• E2F gene regulatory pathway (2001, Homo sapiens,Mus musculus)
• Pathways of fatty acid elongation, LCB, and sphingolipid synthesis in S (2001, Saccharomyces cerevisiae,Homo sapiens)
• Schematic representations of the components and signaling pathways induced by pathogens for activating the Arp2/3 complex-mediated actin rearrangements (2001, NA)
• Basic metabolic pathways in C (2001, NA)
• Cooperation between Beta-AR and B2R signaling leads to augmentation of isoproterenol-induced cAMP accumulation and prevention of BK-induced activation of MAPK (2001, NA)
• Formation of TrkA–src-aPKC complexes (2001, Rattus norvegicus,Homo sapiens)
• Schematic representation of the strategy for generating a functional validation profile of a biochemical network by using the DHFR PCA (2001, NA)
• Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli (2001, Escherichia coli)
• Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 (2001, NA)
• Negative regulation of the Wnt–Beta-catenin pathway by the transcriptional repressor HBP1 (2001, NA)
• Adhesion regulation of nucleocytoplasmic trafficking of signaling molecules (2001, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• Proposed involvement of PIP2 in stress-fiber assembly (2001, NA)
• NEW EMBO MEMBER’S REVIEW (2001, NA)
• Fas-signaling pathways in relation to the cytoskeletal networks, the Golgi-sorting compartment, and the surface membrane (2001, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,Helicobacter hepaticus)
• A molecular mechanism whereby cAMP inhibits T cell function (2001, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Oryctolagus cuniculus,vectors)
• The hypothesized biochemical pathway responsible for the hyperproliferative phenotype of Nf1 +/− mast cells in response to SCF (2001, NA)
• Signaling pathways that may mediate eNOS glycosylation and phosphorylation in vascular endothelial cells (2001, NA)
• Network of metabolic pathways leading from Suc (orange, top left) to the volatile phenylpropanoids, phenylpropenes, and terpenoids formed in EMX-1 basil peltate glands (outlined with yellow backgrounds) (2001, NA)
• gp130 cytokine family pathways on anterior pituitary cells (2001, NA)
• Corticotroph SOCS-3 as an intracellular suppressor of cytokine signaling (2001, NA)
• Purine metabolism in S (2001, NA)
• EGL-15/FGFR signaling pathway (2001, Caenorhabditis elegans,Homo sapiens)
• The TGF-&bgr;/Smad pathway and its interrelationship with mediators of inflammatory signals (2001, NA)
• Model for Nrarp feedback regulation of Notch signaling (2001, Danio rerio,Xenopus laevis,Rattus norvegicus,Homo sapiens)
• Role of E2F1 in the DNA damage response (2001, Homo sapiens,Mus musculus)
• Diagrammatic representation of a rodent taste bud and important components of the bitter transduction pathway (2001, NA)
• Calcium-activated signaling pathways that regulate gene transcription (2001, NA)
• RegA regulation by differential degradation (2001, NA)
• Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak (2001, NA)
• Erk activation following TCR stimulation (2001, NA)
• Triple membrane-passing signal mechanism of EGFR transactivation (2000, Mus musculus,Rattus norvegicus,Homo sapiens)
• ERKI/II (MAPK) can serve as a convergence site for multiple extracellular signals known to induce plasticity in mature neurons (2000, Rattus norvegicus,Homo sapiens)
• Signalling pathway proposed for the relaxant agents VIP, isoprenaline, forskolin, SIN-1, SNP and ANF in isolated smooth muscle cells of the guinea-pig gastric fundus (2000, Cavia porcellus,Homo sapiens)
• Schematic pathway for TNFA and IL-1B signaling of cellular proliferation (2000, Canis lupus familiaris,Homo sapiens)
• Proposed scheme for a second messenger pathway triggered by TGFB1 leading to the induction of ZEBRA (2000, NA)
• Human SHH-PTCH-GLI pathway (left) and its links to human diseases (right) (2000, NA)
• Curbing the nuclear activities of Beta-catenin (2000, Danio rerio,Homo sapiens)
• Known components of the Wnt pathway in the male seam (2000, NA)
• An EGF receptor/Ral-GTPase signaling cascade regulates c–Src activity and substrate specificity (2000, NA)
• Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals (2000, NA)
• Key elements of RANK signaling (2000, NA)
• Signaling through mammalian and Drosophila Toll-family receptors (TLRs) (2000, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Pleiotropic effects of insulin to promote adipose storage (2000, Mus musculus,Homo sapiens)
• Hypothesized effects of ketones on metabolic blocks induced by AB1–42 and MPP+ (2000, NA)
• Caspase activation and apoptosis in Drosophila (2000, NA)
• Regulation of E2F by hDM2 (2000, Homo sapiens,Mus musculus)
• Schematic drawing that shows the importance of cell-to-cell and cell-to-matrix-interactions in endothelial cell survival (2000, NA)
• Schematic model of cyclin E-associated kinase activity as an integrative convergence point for the regulation of G1/S transition by the “classic” pRb/E2F and the “parallel” Myc-dependent pathways in mammalian cells (thick arrows) (2000, Homo sapiens,Rattus norvegicus)
• Ins and outs of protein phosphorylation (2000, NA)
• Ras-mediated signaling pathways (2000, NA)
• Signaling pathways regulating Raf and MAPK in CHO cells (2000, NA)
• Oxidative stress signaling pathways that lead to transcription of the ctt1+ gene (2000, NA)
• Carbon fluxes, expressed in micromoles of carbon per gram per hour, operating during growth of L (2000, NA)
• Two pathways from gp130 to hypertrophic gene expression (2000, Mus musculus,Homo sapiens)
• Cytokines and their receptors in cardiovascular diseases (2000, Mus musculus,Homo sapiens)
• Hypothetical pathway for GA biosynthesis in maize (2000, Zea mays)
• Summary of cAMP signaling pathways in GT1 cells (2000, NA)
• Signal transduction pathways in N (2000, NA)
• Cell cycle arrest by transforming growth factor (TGF)B and their deregulation in cancer (2000, NA)
• Transforming growth factor (TGF)Beta-induced growth inhibition (2000, Homo sapiens,Mus musculus,Citrus macrophylla)
• Differential effect of B1C and B1A integrin cytoplasmic variants on FAK, AKT, and MAP kinase pathways (2000, NA)
• Outline Model for the Genetic Control of Appressorium Turgor Generation by the Rice Blast Fungus M (2000, NA)
• Shc/Grb2/Gab2/PI-3K Akt pathway (2000, Mus musculus,Homo sapiens)
• Model illustrating the relative positioning of aPKC within the NGF signaling cascades for survival and differentiation (2000, NA)
• Common and distinct activities of TGFB and BMP in C2C12 cells (2000, NA)
• The putative functional organization of Ras and Rap1 by the TCR-CD4-CD45 interacting complex (2000, Cervus elaphus,Homo sapiens)
• Aerobic and anaerobic metabolic pathways of rice (2000, NA)
• Models for the different functions of APR-1 (2000, NA)
• Mitochondrial intermembrane junctional complexes and their role in cell death (2000, NA)
• Regulation of MEF2 activity by CaMK signaling (2000, Mus musculus,Rattus norvegicus,Homo sapiens)
• Two-step model of type 1/type 2 effector T-cell differentiation (2000, NA)
• Hypothetical biosynthetic pathway of coumermycin A1 (2000, Streptomyces rishiriensis)
• Ras pathway regulation of hTBP promoter activity in primary hepatocytes (2000, NA)
• PDGF-PI3K–derived pathways that affect cytoskeletal organization and cell migration (2000, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Schematic model indicating the presence of two potential insulin receptor–dependent signal transduction pathways (2000, NA)
• MAPK pathways regulating invasive-filamentous and mating developments (2000, NA)
• Model showing interactions of surface AChR with associated proteins and a suggested mechanism for the Rac/Cdc42-mediated clustering of these proteins in response to agrin (2000, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Apoptotic pathways leading to caspase activation, loss of plasma membrane lipid asymmetry, and sphingomyelin hydrolysis (2000, NA)
• Signal transduction cascades regulating pseudohyphal differentiation in S (2000, NA)
• NEW EMBO MEMBERS’ REVIEW (2000, DNA viruses)
• Comparison of the protein kinase/phosphatase signaling pathways in flies, worms, and humans (see text for description) (2000, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Citrus medica,Homo sapiens,Mus musculus)
• The basic functioning of MAPK pathways (2000, NA)
• Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis (2000, Xenopus laevis,Homo sapiens)
• Schematic diagram showing possible points of convergence of intracellular signaling cascades that might lead to NE plus ATP-mediated synergism (2000, NA)
• Multiple signaling pathways regulate the cell death pathway in sympathetic neurons (2000, Rattus norvegicus,Homo sapiens)
• PAC1receptor intracellular signaling (2000, Rattus norvegicus,Homo sapiens)
• Model depicting the role of CAS/Crk and ERK signaling pathways in mediating cell migration and suppressing apoptosis during invasion of the ECM (2000, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,vectors)
• Proposed model of the DEN-2 virus-induced apoptotic signaling pathways (2000, NA)
• Signaling pathways involved in NCAM-induced neurite outgrowth (2000, Rattus norvegicus,Homo sapiens)
• The FN-dependent matrix survival pathway activated in primary RSF when serum is absent (2000, NA)
• Transduction pathways activated by recombinant somatostatin sst2(a) or sst2(b) receptor isoforms and proposed mechanism which determines the proliferative fate of the host cell (2000, Rattus norvegicus,Homo sapiens)
• The roles that Cdc42 and Rac play in stimulating exocytosis of secretory granules in RBL-2H3 cells (2000, NA)
• c-Src and PDGFR are connected functionally to each other and provide links to cell-cycle regulators in Gq-coupled 5-HT2B receptor mitogenic signaling (2000, Mus musculus,Homo sapiens)
• Hypothetical pathways involved in ITF signaling (2000, Homo sapiens,Rattus norvegicus)
• Signaling pathways regulating mating of S (2000, NA)
• Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II (2000, NA)
• Interphase/S phase omission between the two meiotic divisions (2000, NA)
• Signaling cascades regulating virulence of C (2000, NA)
• Pathway leading from sarcomere protein gene mutation to hypertrophic cardiomyopathy and the role of an abnormal Ca2+response (2000, Homo sapiens,Mus musculus)
• An integrated view of the biology of Halobacterium NRC-1 (2000, NA)
• Phosphorylation-dependent targeting of CREB to proteasomal degradation by hypoxia (2000, Mus musculus,Homo sapiens)
• Usurpation of the Ras signaling pathway by reovirus (2000, Reovirus sp.)
• Model showing the possible relationship of dTOR with the insulin pathway (2000, Saccharomyces cerevisiae,Drosophila melanogaster,Homo sapiens)
• Antiangiogenic Gene Therapy in Cancer (2000, Mus musculus,Homo sapiens)
• Hypothesized interaction of D2receptors and NMDA receptors in the striatum (2000, Rattus norvegicus,Homo sapiens)
• Hypothetical LYar and LYas cells (2000, NA)
• Activation of specific target genes by TGFB and Wnt pathways (2000, NA)
• Model of TCT and endotoxin signaling (2000, NA)
• The possible functions of the Arabidopsis ANP1 and tobacco NPK1 MAPK pathways (2000, NA)
• EGFR transactivation by GPCRs and cytokine receptors (2000, Mus musculus,Rattus norvegicus,Homo sapiens)
• Diagram illustrating how the Rb and p53 pathways are linked to form a complex tumor suppressor network (2000, NA)
• Attenuation of cytokine signaling (2000, Drosophila melanogaster,Leishmania major,Schistosoma mansoni,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Murine leukemia virus)
• Poly(ADP-ribosyl)ation-mediated up-regulation of transcription (2000, NA)
• The IFNG receptor-mediated intracellular signalling pathways (modified from ) (2000, NA)
• Binding of IL-12 to the IL-12RB1 and B2 chains induces phosphorylation of the kinases Tyk2 and Jak2, which associate with the cytoplasmic tails of the B1 and B2 chains, respectively (2000, NA)
• Proposed pathway of EGF-induced cell proliferation of ER− breast cancer cells (2000, NA)
• Scheme summarizing proposed interactions between NGF signaling and apoptotic pathways (1999, NA)
• Postreceptor adaptations of the cAMP pathway observed in response to chronic antidepressant treatment (1999, NA)
• Molecular mechanism underlying TIMP-1–mediated suppression of hepatocarcinogenesis (1999, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Capra hircus,Molva molva,Betapolyomavirus macacae)
• Regulation of the Spc1 SAPK by PP2C and the Pyp tyrosine phosphatases (1999, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Schizosaccharomyces pombe 972h-,Homo sapiens)
• MAP kinase signaling via Raf-1 and B-Raf (1999, NA)
• Models for Ebi function in R7 induction (1999, NA)
• Hypothetical signaling pathways by which Beta-catenin might integrate cell adhesion, cell cycle, and apoptosis (1999, NA)
• Fas (death receptor) signaling pathway and its inhibition (1999, NA)
• Model depicting proposed roles of PTEN, Shc, and FAK in integrin- and growth factor–mediated cell motility (1999, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Capra hircus,Glycine max,vectors,Streptomyces alboniger)
• GH JAK-STAT intracellular signaling pathway (1999, NA)
• Distinct signaling pathways are directly involved in the phenotypic determination of visceral and vascular SMCs (1999, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,vectors,Rous sarcoma virus)
• SON-1 function (1999, Caenorhabditis elegans,Homo sapiens)
• Viral inhibitors of the PKR pathway (1999, NA)
• Signal transduction pathways operating in hippocampal synaptic plasticity (1999, NA)
• The role of the Cdc28 complex in control of filamentous growth (1999, Saccharomyces cerevisiae,Homo sapiens)
• Proposed signal transduction pathways involved in PKC-mediated SRE activation (1999, Mus musculus,Homo sapiens)
• The role of Hsl7p during filamentous growth (1999, Saccharomyces cerevisiae,Homo sapiens)
• IFNG signaling pathway showing the defects in the human fibroblast mutants B3, B9, and B10 (1999, NA)
• PACAP type I receptors couple through AC- or PLC-dependent signaling cascades to differentially regulate A7- and A3*-AChR function (1999, Gallus gallus,Homo sapiens)
• Apoptotic and antiapoptotic signaling pathways (1999, NA)
• Stimulation of iNOS production by Pln is dependent on the IFNG signaling pathway (1999, Streptococcus pneumoniae)
• CaM-Ks act as positive regulators of the ERK signaling cascade (1999, Rattus norvegicus,Cervus elaphus,Homo sapiens)
• JAK/STAT pathway and the establishment of dorsoventral polarity in the eye disc (1999, NA)
• Proposed model for translational homeostasis in response to changes in eIF4E concentration (1999, Mus musculus,Homo sapiens)
• Ras effector pathways in NGF stimulated PC12 cells (1999, NA)
• Differential PKB signaling to S6K1 and 4E-BP1 (1999, NA)
• Interplay between cell contacts, the cytoskeletal network, and the transcription factors c-Jun and GR (1999, Gallus gallus,Homo sapiens)
• Signaling pathways for NFKB activation by IL-1B (1999, NA)
• MAPK signaling in mediating Mos mRNA polyadenylation (1999, Homo sapiens)
• Shp-2 functions in promoting cell growth and survival (1999, Mus musculus,Homo sapiens)
• Control of LHB gene expression by Egr-1, Ptx1, and SF-1 (1999, NA)
• IL-1 signaling pathway (1999, Homo sapiens)
• Axial and appendicular cartilage (1999, NA)
• Pathogenesis of the inflammatory response (1999, Human T-cell leukemia virus type I)
• IFNG/STAT1 and IL-6/STAT3 or IL-6/NF-IL6 signaling pathway (1999, NA)
• Signaling pathways implicated in the hypertrophic response: the SAPKs, calcineurin/NF-AT3, and a putative costimulatory pathway (1999, Homo sapiens)
• P53 transcriptional pathway (1999, NA)
• Regulation of reproductive growth and metabolism by the DAF-2 insulin receptor-like signaling pathway (1999, Caenorhabditis elegans,Homo sapiens)
• P58IPK suppression of apoptosis (1999, NA)
• Btk-dependent TFII-I function (1999, NA)
• cAMP stimulates p70s6k and Akt through distinct pathways (1999, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways required for transformation by v-Src (1999, NA)
• Photosynthesis and photoassimilate metabolism in cyanobacteria (1999, NA)
• PI3′K signaling modules in mammals and nematodes have implications for cancer (1999, Caenorhabditis elegans,Homo sapiens)
• The central role of the E2F transcription factors in cell proliferation and apoptosis (1999, NA)
• Anchorage-dependent cell growth (1999, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Cas-mediated activation of the SRE (1999, NA)
• Proposed relationship between the Lace and MAPK cascades in the imaginal disc cells (1999, NA)
• Caveolins negatively regulate signaling along the p42/44 MAPK cascade (1999, NA)
• The mechanism of regulation of PLCG2 tyrosine phosphorylation and activation by LAT (1999, NA)
• Schematic diagram illustrating a model for the antagonistic roles of Dp110 and DPTEN in Drosophila growth control (1999, NA)
• A proposed functional role for PKC BII in colon carcinogenesis (1999, Glycine max,Arachis hypogaea,Ulex europaeus,Vigna unguiculata subsp. cylindrica,Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus,Cerobasis alpha)
• Proposed biosynthetic pathway for cotton terpenoids (1999, Verticillium dahliae)
• How ECSIT may participate in Toll/IL-1 signaling (1999, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Purinoceptor-coupled Cl− channels in mouse heart: a novel, alternative pathway for CFTR regulation (1999, Mus musculus,Homo sapiens)
• Evolutionary conservation of the DNA damage and the replication checkpoints (1999, NA)
• Models for SUR-6 PP2A-B function in the vulval induction pathway (1999, Caenorhabditis elegans,Homo sapiens)
• Mechanism of microglial activation by fibrillarBA and PrP peptides responsible for neurotoxicity (1999, NA)
• Regulation of TNF-R1signaling pathways during apoptosis (1999, NA)
• Egfr signaling pathway in dorsal follicle cell fate determination (1998, Drosophila melanogaster,Homo sapiens)
• Signalling pathways for EGF activation of c-jun (1998, NA)
• Alternative pathways for induction of T-cell-independent and T-cell-dependent IFNG synthesis (1998, Toxoplasma gondii,Homo sapiens)
• The CD5-induced signaling pathway, which is mediated by PI 3-kinase and Vav, resulting in the activation of Rac1 (1998, Homo sapiens)
• Possible signaling pathways involved in cer-induced IKir inhibition (1998, Rattus norvegicus,Homo sapiens)
• Schematic diagram showing steps in the signaling pathway by which P (1998, Pseudomonas aeruginosa,Homo sapiens)
• A current model of the yeast HOG osmoregulatory signal transduction pathway (1998, NA)
• Integration of growth factor-, retinoid-, and ECM-derived signaling pathways during normal mucosecretory cell differentiation (1998, Homo sapiens)
• Both the MAPK pathway and the A kinase pathway converge on FLO11 in the regulation of pseudohyphal growth (1998, NA)
• Spore wall assembly pathway of S (1998, NA)
• Working model of the PTEN regulatory network (1998, Mus musculus,Rattus norvegicus,Homo sapiens,Capra hircus,Glycine max,Cyrestis thyodamas)
• Two signal transduction pathways for mating, morphogenesis, and virulence in U (1998, Ustilago maydis)
• Integration of tyrosine kinase signaling to both cAMP and MAPK 1,2 pathways, resulting in cell cycle arrest and the reduction of MAPK 1,2 triggered proliferation (1998, NA)
• Stress response pathway of S (1998, NA)
• Schematic model illustrating 20, 12(S)-, and 15-HETE as mediators of MAPK and cPLA2 activation in response to NE, Ang II, and EGF (1998, Oryctolagus cuniculus,Homo sapiens)
• Furin trafficking in the endosomal system (1998, NA)
• Role of Win1 in controlling the fission yeast stress-activated Sty1 MAPK (1998, Schizosaccharomyces pombe,Schizosaccharomyces pombe 972h-,Homo sapiens)
• Proposed model for Ca2+signaling in response to P (1998, NA)
• Influence of OdDHL on the immune system (1998, NA)
• Proposed regulatory role of Ptc1p in the HOG response pathway (; ) (1998, Saccharomyces cerevisiae,Homo sapiens)
• Pheromone response pathway of S (1998, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Analysis of the region between styR and styA (1998, Escherichia coli,Pseudomonas sp. VLB120)
• Schematic diagram showing the function of msn, NIK, and mig-15 (see text for details) (1998, NA)
• Calcium-mediated signaling and the regulation of actin assembly and tension (1998, NA)
• Spn function (1998, Saccharomyces cerevisiae,Dictyostelium discoideum,Homo sapiens)
• Scheme of altered signal transduction and enhanced opioid efficacy in GABAergic nerve terminals of PAG after chronic treatment with morphine (1998, NA)
• Proposed pathway forl-glutamate-mediated inhibition of NE-dependent melatonin synthesis in pinealocytes (1998, NA)
• Separate pathways regulate synapse-specific and electrical activity-dependent transcription (1998, Mus musculus,Homo sapiens)
• Signaling pathways of IFNA, IFNB, and cytoplasmic dsRNA (1998, NA)
• Stress response pathway in fission yeast (1998, Schizosaccharomyces pombe,Schizosaccharomyces pombe 972h-)
• Hyperosmotic stress response in S (1998, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Schematic drawing showing the relationship of PKA and hh pathways on CI proteolysis and activity (1998, Drosophila melanogaster,Homo sapiens)
• Pheromone response pathway of S (1998, NA)
• Working model of the mechanisms whereby PS-1 mutations render neurons vulnerable to mitochondrial dysfunction and apoptosis (1998, NA)
• Model illustrating the signaling cascades leading to an increase in protein synthesis (1998, NA)
• Schematic pathway of pyruvate metabolism in L (1998, Lactococcus lactis)
• Recycling pathway of murein turnover products in E (1998, NA)
• Genetic models for ptp-2 signaling during (A) oogenesis and (B) vulval development (1998, NA)
• Pheromone response pathway of S (1998, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Model to illustrate how SHP-2 regulates coupling of the TCR to the Ras/MAPK pathway (1998, Xenopus laevis,Triportheus paranensis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Metabolic reaction network analyzed from the human erythrocyte containing 29 metabolites and the related 51 fluxes (37 internal and 14 exchange fluxes) (1998, NA)
• HToll and TNFR-1 signaling pathways (1998, Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus,vectors)
• NFAT/AP-1 complex regulation by Ras family GTPases in mast cells (1998, NA)
• Determinants of specificity in TGFB signal transduction (1998, Mus musculus,Xenopus laevis,Homo sapiens)
• Simplified gluconeogenic pathway from [2-13C]pyruvate (1998, Mus musculus,Homo sapiens)
• CRP and mannan-binding lectin (MBL) on complement activation (1998, NA)
• Model depicting role of MAP kinase in cell migration (1997, Saccharomyces cerevisiae,Armoracia rusticana,Pinus torreyana,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Gallus gallus)
• Adhesion-dependent and -independent pathways leading to DNA synthesis in ET-1-treated astrocytes (1997, NA)
• BMPR-specific functions in limb development and molecular pathways elicited by IHH signaling (1997, NA)
• The antagonistic action of hormone-activated nuclear receptors on AP-1 activity through the inhibition of the JNK signal transduction pathway (1997, NA)
• Metabolism of beverage alcohol (1997, Homo sapiens,Rattus norvegicus)
• Role of the DAF-3/DAF-8/DAF-14 Smads in dauer formation, as described in text (1997, NA)
• P15/16, cyclin D:Cdk4/6, pRb, E2F pathway (1997, NA)
• Oncogenes and signaling pathways (1997, NA)
• Neuronal model for olfactory associative learning in Drosophila, involving the cAMP signal transduction pathway (1997, Drosophila melanogaster,Homo sapiens)
• The Wnt signaling pathway showing competition between endogenous and ectopic Beta-catenin for interactions with several protein partners, including cadherin, APC, and Lef/ Tcf (1997, NA)
• The CREM feedback loop in transducing a rhythmic clock-directed signal into rhythmic hormone synthesis (1996, NA)
• Hypothetical scheme accounting for NMDA-triggered neurodegeneration (1996, Rattus norvegicus,Homo sapiens)
• Components of the metabolic transmission pathway within a Purkinje cell dendrite (1996, Oryctolagus cuniculus,Homo sapiens)
• Illustrative model of the IFN signal transduction pathway (1995, NA)
• PKR pathway (1995, NA)
• Fear Conditioning, Synaptic Plasticity, and the Amygdala: Implications for Posttraumatic Stress Disorder (, Mus musculus,Rattus norvegicus,Homo sapiens,Brassica napus)
• Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Convergent pathogenic pathways in Alzheimer’s and Huntington disease: Shared targets for drug development (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin (, NA)
• Pathogenetic Importance and Therapeutic Implications of NFKB in Lymphoid Malignancies (, Homo sapiens)
• GRK2 – A Link Between Myocardial Contractile Function and Cardiac Metabolism (, NA)
• Metabolic requirements for the maintenance of self-renewing stem cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,NA)
• Metabolic requirements for the maintenance of self-renewing stem cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,NA)
• Metabolic requirements for the maintenance of self-renewing stem cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,NA)
• TLR and BCR signaling and integration in CSR and antibody responses (, Human papillomavirus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Polyomavirus sp.,Drosophila melanogaster,Plasmodium falciparum,Toxoplasma gondii,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Gnathostomata,Cyclostomata,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Corynephage beta)
• Many functions of promyelocytic leukemia nuclear bodies and PML as a negative regulator of the PI3-kinase/Akt/mTOR pathway (, NA)
• Emerging Role of Autophagy in Alcoholic Liver Disease (, NA)
• Steering tumor progression through the transcriptional response to growth factors and stroma (, Homo sapiens,Mus musculus)
• Combinatorial cytokine regulation of iNOS expression in IMF (, NA)
• Working model of apigenin-induced DNA damage (, NA)
• Evolution of Two-Component Signal Transduction Systems (, Escherichia coli,Pseudomonas aeruginosa,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Pseudomonas syringae,Streptomyces coelicolor,Cereibacter sphaeroides,Enterococcus faecium,Yersinia pestis,Ralstonia solanacearum,Caulobacter vibrioides,Thermotoga maritima,Vibrio harveyi,Bradyrhizobium japonicum,Nostoc punctiforme,Actinomycetales bacterium A,Salmonella bongori,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens)
• Glutamate Metabolism and HIV-Associated Neurocognitive Disorders (, NA)
• CXCL10/IP-10 in Infectious Diseases Pathogenesis and Potential Therapeutic Implications (, NA)
• Summary of the Proceedings from the 10th Annual Meeting of Molecularly Targeted Therapy in NSCLC (, NA)
• Cancer model pathway (, Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• TNF and MAP kinase signaling pathways (, NA)
• TNF and MAP kinase signaling pathways (, NA)
• XPC: Implications in cancer and oxidative DNA damage (, NA)
• Toll-like receptor 4 and hepatic fibrogenesis (, NA)
• Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid - monoacylated phosphatidylinositol dimannoside (, Escherichia coli,Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Mycobacterium tuberculosis H37Rv,Mycobacterium sp.,vectors,unidentified shuttle vector,Homo sapiens,Mus musculus,Capra hircus)
• Proposed frame work for mRNA nanoparticle mediated tumour vaccination (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of PTEN in PI3K/AKT/mTOR signaling and cell proliferation following growth factor binding to its receptor (, Homo sapiens)
• HERITABLE FORMS OF PULMONARY ARTERIAL HYPERTENSION (, NA)
• WNT signaling pathway (, Mus musculus,Cricetulus griseus,Homo sapiens,Bos taurus,Dipturus trachyderma,Moloney murine leukemia virus,NA)
• Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression (, NA)
• Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities (, NA)
• Mesenchymal Stem Cells as Cellular Vectors for Pediatric Neurological Disorders (, NA)
• Circadian Clock in Cancer Development and Therapy (, Homo sapiens)
• Pathways to Tumorigenesis and Persistent Infection (, Human gammaherpesvirus 8)
• Second messenger signals at the leading edge of polarized ameboid cells () (, NA)
• Cell Death and Survival Through the Endoplasmic Reticulum-Mitochondrial Axis (, NA)
• B3 integrin-KRAS-RalB complex drives tumor stemness and resistance to EGFR inhibition (, NA)
• Schematic model of specific KDAC targeting through pharmaco-logic modulation of its regulatory pathway (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Signaling by the TNFR superfamily in B-cell biology and disease (, NA)
• Signaling by the TNFR superfamily in B-cell biology and disease (, NA)
• Signaling by the TNFR superfamily in B-cell biology and disease (, NA)
• Arteriovenous EC specification during embryonic development (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Cavia porcellus,Coturnix coturnix,Homo sapiens,Drosophila melanogaster)
• Calcium Dysregulation in Anesthetic-Mediated Neurotoxicity (, NA)
• Pathways of binding, internalization and processing by immunotoxins and ADCs leading to the killing of target cells (, NA)
• Retinoic acid suppresses the canonical Wnt signaling pathway in embryonic stem cells and activates the noncanonical Wnt signaling pathway (, NA)
• PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA (, NA)
• PATHOGENETIC MECHANISMS OF FOCAL CORTICAL DYSPLASIA (, NA)
• Progress in Central Nervous System Lymphomas (, NA)
• RGS14 at the interface of hippocampal signaling and synaptic plasticity (, NA)
• Toxoplasma gondii effectors are master regulators of the inflammatory response (, NA)
• Mechanisms of cellular invasion by intracellular parasites (, Lutzomyia longipalpis,Phlebotomus papatasi,Homo sapiens)
• Chalcones with minor structural changes result in distinct processes of cell death (, NA)
• Schematic biosynthetic pathways for the major phospholipid (Kennedy Pathway) and sphingolipid classes biosynthesized in mammalian cells and observed in MALDI IMS of mammalian tissues (, NA)
• Toward T Cell Protein–Protein Interaction Activity Relevant to Alopecia Areata (, Homo sapiens,Mus musculus,Bikinia letestui)
• Differential LSEC Signalling in Models of Acute or Chronic Injury (, NA)
• SP600125 and BCI Inhibition in MAPK Signaling Pathway adapted from KEGG 04010 (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetus cricetus,Homo sapiens,Danio rerio)
• LDN Inhibition in TGFB Signaling Pathway adapted from KEGG 04350 (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetus cricetus,Homo sapiens,Danio rerio)
• SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease (, NA)
• Rigosertib is a multi-kinase inhibitor that can influence signaling of multiple pathways important for cellular proliferation and survival (, NA)
• Molecular insights into NF2/Merlin tumor suppressor function (, Homo sapiens,Mus musculus,Drosophila melanogaster,Human immunodeficiency virus 1,NA)
• Surviving Change: The Metabolic Journey of Hematopoietic Stem Cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Sarcopenia, Cachexia and Aging: Diagnosis, Mechanisms and Therapeutic Options (, NA)
• Comprehensive and High Resolution Genome-wide Response of p53 to Stress (, NA)
• Gene Regulatory Networks in Cardiac Conduction System Development (, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Mustela lutreola)
• PCNA and Msh2-Msh6 Activate an Mlh1-Pms1 Endonuclease Pathway Required for Exo1-independent Mismatch Repair (, NA)
• Vitamin D Receptor: A Tumor Suppressor in Skin (, NA)
• Intracellular signaling pathway implicated in the regulation of ENaC activity by bradykinin in the distal nephron (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Ubiquitination of RIP1 is an early pro-survival checkpoint in TNF signaling (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Human gammaherpesvirus 4)
• Regulation of Tenascin Expression in Bone (, NA)
• Regulation of homologous recombination in eukaryotes (, NA)
• Proposed anti-WNV signaling pathways in mosquitoes (, Drosophila melanogaster,Aedes aegypti,Anopheles gambiae,Aedes albopictus,Culex quinquefasciatus,Culex pipiens,Anopheles quadrimaculatus,Parthenos sylvia,Culex restuans,Dengue virus,West Nile virus,Japanese encephalitis virus,Dengue virus type 2,Drosophila X virus,Saint Louis encephalitis virus,Anser sp.,Passer domesticus,Corvus brachyrhynchos,Mus musculus,Cricetus cricetus,Homo sapiens,Equus caballus,NA,NA)
• Dual functions of guggulsterone in the regulation of BSEP and possible mechanism for its cholesterol-lowering effect (, Homo sapiens)
• Pak Signaling in the Development and Progression of Cancer (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Agaricus bisporus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Mouse mammary tumor virus,murine stem cell retroviral vector,NA)
• Death-Defining Immune Responses After Apoptosis (, NA)
• Cartoon depicts IL-15 mediated activation of the PI3K/ERK1/2 and JAK1/STAT3 pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Ras/MAPK signal transduction pathway (, NA)
• Dynamic Role of Beta-Catenin in Synaptic Plasticity (, Lareunionomyces loeiensis,Agaricus bisporus,Cordeauxia edulis,Lawsonia inermis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Canonical Mitogen Activated Protein Kinase (MAPK) pathway signaling (, Homo sapiens,Mycobacterium tuberculosis variant bovis BCG)
• Model Genetic Pathways (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Mangifera indica,Homo sapiens,Mus musculus,Danio rerio,Tobacco etch virus)
• Model Genetic Pathways (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Mangifera indica,Homo sapiens,Mus musculus,Danio rerio,Tobacco etch virus)
• Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics (, Leuciscus leuciscus,Homo sapiens)
• Major physiological functions of the endoplasmic reticulum and their perturbations cause ER stress and activate the unfolded protein response (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Role of Foxo proteins in cardiac hypertrophy (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular Mechanisms of Neurodegeneration in PD (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,prion)
• Genetic association, seasonal infections and autoimmune basis of narcolepsy (, NA)
• Simplified schematic diagram of the IL-8 signaling pathway in neutrophil chemotaxis (, Homo sapiens)
• Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor (, NA)
• Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor (, NA)
• An array of cellular stressors can perturb the folding environment in the endoplasmic reticulum (ER) leading to unfolded or misfolded protein (, NA)
• Caloric Restriction and Chronic Inflammatory Diseases (, NA)
• Motility, Survival and Proliferation (, NA)
• ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC (, NA)
• ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC (, NA)
• ATTENUATION OF MULTI-TARGETED PROLIFERATION-LINKED SIGNALING BY 3,3′-DIINDOLYLMETHANE (DIM): FROM BENCH TO CLINIC (, NA)
• Beyond NPM-ALK driven lymphomagenesis: alternative drivers in Anaplastic Large Cell Lymphoma (, Homo sapiens,Mus musculus,unidentified,Corynebacterium phage gamma)
• Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles (, NA)
• Fibronectin Stimulates Endothelin-1 Synthesis in Rat Hepatic Myofibroblasts via a Src/ERK Regulated Signaling Pathway (, NA)
• AB oligomers activate several ‘stress-response’ kinase pathways in neurons (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,prion)
• Crosstalk of BMP and neurotrophin signaling in neurons (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Adeno-associated virus)
• BMP signaling in promoting axon regeneration (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Adeno-associated virus)
• PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics (, NA)
• Tale of two cytokines: IL-17 and IL-22 in asthma and infection (, NA)
• Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis (, NA)
• Novel molecular pathways in Gorham disease: Implications for treatment (, Homo sapiens,Mus musculus)
• Translational Control by Heme-Regulated eIF2A Kinase during Erythropoiesis (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• current targets of nuclear DNA repair pathway proteins and their functions (, Homo sapiens,Mus musculus)
• Ingenuity pathway analysis (IPA) revealed TGF-beta signaling as the top “connected” network of differentially methylated candidates in HDM-exposed group (, NA)
• Adaptive immunity with Toll-like receptors (, Plasmodium falciparum,Leishmania major,Schistosoma mansoni,Strongyloides venezuelensis,Mycobacterium tuberculosis,Porphyromonas gingivalis,Yersinia pestis,Saccharomyces cerevisiae,Lareunionomyces loeiensis,unidentified influenza virus,H5N1 subtype,Homo sapiens,Mus musculus)
• VEGF Signaling Pathway within endothelial cells (, NA)
• Mechanisms of androgen neurotoxicity and neuroprotection (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of EMT by KLF4 in Gastrointestinal Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Human gammaherpesvirus 4)
• Regulation of EMT by KLF4 in Gastrointestinal Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Human gammaherpesvirus 4)
• Wnts organize presynaptic (CNS and NMJ) and postsynaptic (NMJ) specializations through multiple signaling pathways (, Gallus gallus,Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Canis lupus familiaris)
• Schematic models for the assembly of cohesin and associated factors at double-strand breaks (DSBs), and ATR- and Eco1 (Ctf7)-dependent reactivation of cohesin in G2 phase (, NA)
• Diagram depicting hypothetical mechanisms by which the polycystins directly affect gene transcription and regulate the cell cycle (, NA)
• Targeting the PI3K/Akt/mTOR pathway to treat lymphoma (, Homo sapiens,Human gammaherpesvirus 4)
• Mammalian target of rapamycin, Akt, and phosphatidylinositol 3-kinase signaling (, NA)
• Models of Ras signaling in NF1-deficient GBM cell lines (, Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• Canonical non-Smad pathway tumor growth factor (TGF)B signaling (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,H1N1 subtype,Parechinus angulosus)
• Endothelin and hepatic wound healing (, NA)
• Insulin signal transduction through canonical IRS1/PI3K pathway and through abbreviations: Cbl/CAP/TC10 pathway associated with lipid rafts in the plasma membrane (, NA)
• Protomural role of tumor-associated macrophages (TAM) (, NA)
• Model depicting the pathway of TGFBeta-mediated Bim regulation and apoptosis (, NA)
• The EP4-mediated classical pathway and the EP4-mediated anti-inflammatory pathway (, NA)
• Serotonin pathway in platelets (, NA)
• Phosphatidylcholine (PtdCho) metabolic pathway (, NA)
• PI3K-PTEN-mTOR pathway (, Saccharomyces cerevisiae,Drosophila melanogaster,Nicotiana tabacum,Human papillomavirus,Cerobasis alpha,Human papillomavirus KC5,Homo sapiens,Mus musculus,Gallus gallus)
• Mutations observed in the PI3KCA and p85A (, Saccharomyces cerevisiae,Drosophila melanogaster,Nicotiana tabacum,Human papillomavirus,Cerobasis alpha,Human papillomavirus KC5,Homo sapiens,Mus musculus,Gallus gallus)
• G-protein—coupled receptors, hedgehog signaling and primary cilia (, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Chlamydomonas reinhardtii,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• G-protein—coupled receptors, hedgehog signaling and primary cilia (, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Chlamydomonas reinhardtii,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Hepatitis B virus,NA)
• CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11p110 (, Saccharomyces cerevisiae,Armoracia rusticana,Schizosaccharomyces pombe,Bos taurus,Oryctolagus cuniculus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,vectors)
• Protective mucosal immunity mediated by epithelial CD1d and IL-10 (, NA)
• PRL crosstalk with estrogen, progesterone, EGF/TGFA, and IGF-I (, Homo sapiens,Mus musculus)
• Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention (, NA)
• Protein Kinase PKR and RNA Adenosine Deaminase ADAR1: New Roles for Old Players as Modulators of the Interferon Response (, NA)
• Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii (, NA)
• Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii (, NA)
• Biosynthesis of spiruchostatins (, Pseudomonas sp.,Pseudomonas sp. Q71576,Homo sapiens)
• Therapeutic strategies to target mutant NRAS: Direct targeting strategies include inhibition of RAS transcription by RNA interference and blockade of posttranslational modification by farnesyltransferase inhibitors (, NA)
• Sirt1/AMPK/PGC1/PPAR signaling network (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Adeno-associated virus,Chlamydomonas reinhardtii,adeno-associated virus 2,Ciona intestinalis,Taxila haquinus,Homo sapiens)
• Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells (, NA)
• Activating PI 3-kinase to dampen inflammation (, Panax ginseng,Eleutherococcus koreanus,Homo sapiens,Mus musculus)
• Highest confidence network of genes influenced by CLOCK knockdown (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis,Bathymaster signatus,NA)
• Challenges in Vaccination of Neonates, Infants and Young Children (, Streptococcus pneumoniae,Haemophilus influenzae,Streptococcus pneumoniae 23F,Enterovirus C,Variola virus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Corynebacterium phage gamma,Catopsilia pomona)
• Targeting the B cell receptor signaling pathway in B lymphoid malignancies (, NA)
• Targeting the B cell receptor signaling pathway in B lymphoid malignancies (, NA)
• Cellular and molecular interactions between HCL cells and their microenvironment (, Homo sapiens)
• TGFB1/SMAD3 signaling as an integrator of fibrotic mechanisms in the kidney (, NA)
• Vitamin D Metabolism and Function in the Skin (, Homo sapiens,Mus musculus,Gallus gallus)
• Genetics of Pulmonary Arterial Hypertension (, NA)
• Major signaling pathways involved in regulation of renin (, NA)
• GAi-mediated activation of the PI3K-Akt-mTORC1 pathway in response to EGF (, NA)
• Brain Arteriovenous Malformation Pathogenesis: A Response-to-Injury Paradigm (, Homo sapiens,Mus musculus)
• In the presence of sclerostin-neutralizing monoclonal antibodies (Scl-Ab), the osteocyte-produced Wnt signaling pathway antagonist sclerostin is prevented from binding to the Wnt co-receptor LRP5/6 (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis)
• An Unexpected Journey: Lysine Methylation Across the Proteome (, NA)
• Signaling pathways that regulate mammalian autophagy (, NA)
• Role and targeting of Aurora kinases in head and neck cancer (, NA)
• CPAcP interaction with HER-2 and PI3K/Akt pathway in regulating prostate cell homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Simian-Human immunodeficiency virus)
• Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging (, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Papio hamadryas,Saccharomyces cerevisiae)
• Tissue-specific Insulin Signaling in the Regulation of Metabolism and Aging (, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Papio hamadryas,Saccharomyces cerevisiae)
• BAD pathway in genes associated with induced cisplatin-resistance (, NA)
• Notch1 Regulates the Effects of Matrix Metalloproteinase-9 on Colitis-Associated Cancer in Mice (, NA)
• Graphic representation of the Pten/PI3K/Akt signaling pathway (, NA)
• Positive feedback loop involving the oxLDL/LOX-1 signaling pathway and LOX-1 modulators (, Mus musculus,Rattus norvegicus,Candida dubliniensis,Salvia miltiorrhiza,Homo sapiens,Oryctolagus cuniculus,Human betaherpesvirus 5,Corynephage beta)
• LOX-1 signaling mechanistically links atherosclerosis, hypertension, and diabetes (, Mus musculus,Rattus norvegicus,Candida dubliniensis,Salvia miltiorrhiza,Homo sapiens,Oryctolagus cuniculus,Human betaherpesvirus 5,Corynephage beta)
• Genome wide proteomics of ERBB2 and EGFR and other oncogenic pathways in inflammatory breast cancer (, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Methanosarcina acetivorans)
• Characterization of glycoproteins in pancreatic cyst fluid using a high performance multiple lectin affinity chromatography platform (, NA)
• Intestinal SIRT1 is an important regulator of systemic bile acid homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Dynamics of BMP Signaling in Limb Bud Mesenchyme and Polydactyly (, Oryctolagus cuniculus,Gallus gallus,Capra hircus,Xenopus laevis,Dipturus trachyderma,Equus asinus,Homo sapiens,Mus musculus)
• Do Mantle Cell Lymphomas have an “Achilles Heel”? (, Homo sapiens)
• Non-coding RNA regulation of synaptic plasticity and memory: implications for aging (, NA)
• Tumor necrosis factor A stimulates endothelin-1 synthesis in rat hepatic stellate cells in hepatic wound healing through a novel IKK/JNK pathway (, NA)
• Ras/MAPK signaling cascade and small molecule inhibition (, Homo sapiens,Mus musculus,Panthera pardus)
• Myocardial abnormalties revealed in human HFpEF (, NA)
• Schematic summary indicating the mechanism by which Cdt, specifically CdtB, affects the PI-3K signaling pathway and the production of pro-inflammatory cytokines (, Aggregatibacter actinomycetemcomitans,Homo sapiens)
• MIF-CD74-Lyn signaling cascade during osteoclastogenesis (, NA)
• Ebolavirus VP35 suppresses IFN production from conventional but not plasmacytoid dendritic cells (, unidentified influenza virus,Human gammaherpesvirus 8,Ebola virus,Venezuelan equine encephalitis virus,Myxoma virus,Zaire ebolavirus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Cavia porcellus,Chlorocebus aethiops,Gallus gallus,Enterobacteria phage A549,NA,NA,NA)
• GATA regulation of Notch signaling in the intestine (, Mus musculus,Rattus norvegicus,Homo sapiens)
• BMPs in endothelial cell function and dysfunction (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio)
• Gaps in conventional treatment of heart failure include deranged Beta-AR signaling, distorted Ca2+ cycling with depletion of SR Ca2+ levels, diastolic dysfunction, and cell death (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Cricetus cricetus,Homo sapiens,Adeno-associated virus)
• Cytomegalovirus microRNAs (, NA)
• Interferon-inducible effector mechanisms in cell-autonomous immunity (, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,Ebola virus,Measles morbillivirus,Encephalomyocarditis virus,Sindbis virus,Coxsackievirus,SARS coronavirus NS-1,Influenza A virus H3N2,Murid gammaherpesvirus 4,Tick-borne encephalitis virus,Influenza B virus,SARS coronavirus LC3,Ectromelia virus,Thogotovirus thogotoense,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Mycobacterium tuberculosis variant bovis BCG,Bacillus anthracis,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Campylobacter jejuni,Chlamydia trachomatis,Acinetobacter baumannii,Mycobacterium avium,Serratia marcescens,Burkholderia cepacia,Anaplasma phagocytophilum,Chlamydia muridarum,Chlamydia psittaci,Mycobacterium tuberculosis variant africanum,Mycoplasmopsis bovis,Granulibacter bethesdensis,Plasmodium falciparum,Trypanosoma cruzi,Toxoplasma gondii,Leishmania major,Leishmania donovani,Plasmodium berghei,Plasmodium yoelii,Mus musculus,Rattus norvegicus,Homo sapiens,Arabidopsis thaliana,Danio rerio,unidentified,NA,NA,NA,NA)
• MC1R, the cAMP pathway and the response to solar UV: Extending the horizon beyond pigmentation (, NA)
• Biochemical Signaling of PD-1 on T Cells and Its Functional Implications (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Xenopus laevis)
• Principal melatonin-receptor signaling pathways (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Mesocricetus auratus,Oryctolagus cuniculus,Ovis aries,Homo sapiens)
• IL-1A and IL-1B synthesis and signal transduction pathway (, NA)
• WWOX At The Crossroads Of Cancer, Metabolic Syndrome Related Traits And CNS Pathologies (, NA)
• Targeting the Apoptosis Pathway in Hematologic Malignancies (, NA)
• Coactivator dependent signaling regulates various biological functions, and deregulation causes diseases (, Saccharomyces cerevisiae,Theobroma cacao,Homo sapiens,Mus musculus,Gallus gallus)
• Immunoregulatory molecules are master regulators of inflammation during the immune response (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Candida albicans interactions with epithelial cells and mucosal immunity (, NA)
• Immunoregulatory molecules are master regulators of inflammation during the immune response (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Bimodal pathway of Notch signaling during pancreas development (, NA)
• Comparative genome-wide transcriptional analysis of human left and right internal mammary arteries (, NA)
• Generic model of fluid flow mechanotransduction modulation of vascular SMC gene expression and function (, NA)
• The integration of the p38 MAPK signaling pathway with Mef2-dependent recruitment of the Ash2L complex to muscle-specific promoters (, Homo sapiens,Mus musculus)
• Pathways of androgen biosynthesis (, NA)
• Smac mimetics and TNFA: a dangerous liaison? (, NA)
• Tumor Necrosis FactorA Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor-Beta-activated Kinase 1 (TAK1)-dependent Signaling Pathway (, Mus musculus,Homo sapiens)
• Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regression (, NA)
• Proposed pathway for the interaction between estrogen receptor (ER)A and growth factor (GF) signaling pathways and regulation by estradiol (E2) and genistein (Gen) (, Homo sapiens,Mus musculus,Turdus migratorius)
• Proposed pathway for the interaction between estrogen receptor (ER)A and growth factor (GF) and growth factor receptor (GFR) signaling pathways and regulation by estradiol (E2) and progesterone (P4) (, Homo sapiens,Mus musculus,Turdus migratorius)
• Reduced expression levels of Progranulin (GRN) are present from early embryonic life (, Homo sapiens,Mus musculus)
• New Insights into insulin resistance in the diabetic heart (, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• The role of sphingosine kinase localization on substrate utilization and delivery of S1P to specific sites for secretion or loading of intracellular effectors (, NA)
• Axon regeneration mechanisms (, Homo sapiens,Caenorhabditis elegans)
• Growth factor- and cytokine-regulated pathways are activated during liver regeneration (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Stem Cell Lineage Specification: You Become What You Eat (, NA)
• CDK 4/6 inhibitors sensitize PIK3CA Mutant Breast Cancer to PI3K inhibitors (, Homo sapiens,Mus musculus)
• INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (, NA)
• Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus,Adeno-associated virus,Homo sapiens,Dipturus trachyderma)
• Apoptotic pathway to cell death from the perspective of the Bcl-2 family of proteins.1, The intrinsic pathway is initiated by various signals, principally extracellular stimuli (, Homo sapiens,Mus musculus)
• Physiology and Metabolism of Tissue Engineered Skeletal Muscle (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio)
• Determinants of Breast Cancer Progression (, NA)
• Inhibition of protein synthesis by rocaglamides (, NA)
• Apoptosis pathways affected by rocaglamides (, NA)
• Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis and Signaling (, NA)
• Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma (, NA)
• NFKB activation pathways and the impact of S-glutathionylation (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• Shaping the mammalian auditory sensory organ by the planar cell polarity pathway (, NA)
• The development of the auditory sense organ (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Drosophila melanogaster,Phoenicopterus roseus)
• Mechanism of converting epigenetic marks (, Nicotiana tabacum,Brassica napus,Cannabis sativa,Mus musculus,Rattus norvegicus,Homo sapiens)
• MicroRNAs As Biomarkers For Clinical Features Of Lung Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Molecular Approaches to Thyroid Cancer Diagnosis (, Homo sapiens)
• Feedback pathways of AR, PTEN, and PI3K (, NA)
• Biosynthesis and Roles of Phospholipids in Mitochondrial Fusion, Division and Mitophagy (, NA)
• Proposed molecular interaction between two neuropathologies such as major depressive disorder and Alzheimer’s disease (, NA)
• Model is presented whereby serine phosphorylation of IRS-1 serves as a mediator of Ang II to inhibit insulin-induced Akt Thr308 phosphorylation (, NA)
• Main signaling cascades of the IGF-1R (, NA)
• Estrogen hormone actionEstrogens mediate their responses through estrogen receptors (ERs) via multiple methods (, NA)
• ATX-LPA Receptor Axis in Inflammation and Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Mouse mammary tumor virus)
• CCR-14-0330R1: Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer (, NA)
• Relationship between Ras-driven signaling pathways, ROS, Hsp90, and ER stress (, Homo sapiens)
• Modulatory effects of low-dose H2O2 on the functions of pDCs (, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana,unidentified influenza virus)
• IGF but not the EGF signaling pathway is regulated by the NEDD4-PTEN circuitry (, NA)
• Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome (, Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Sonic Hedgehog Signaling in Basal Cell Nevus Syndrome (, Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (, NA)
• Two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment (, NA)
• Back to the Future: Oral targeted therapy for RA and other autoimmune diseases (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Saccharomyces cerevisiae,Mycobacterium tuberculosis)
• Sphingosine-1-phosphate in endothelial barrier function (, NA)
• Genome-wide association analysis of anti-TNF drug response in rheumatoid arthritis patients (, NA)
• Schematic depicting pH- and serotonin-mediated inactivation of TASK channels (, NA)
• The genetic signatures of pediatric high-grade glioma: no longer a one-act play (, Homo sapiens,Mus musculus)
• Proposed model of tetrandrine-induced apoptosis in prostate cancer (, NA)
• Change or Die: Targeting Adaptive Signaling to Kinase Inhibition in Cancer Cells (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Change or Die: Targeting Adaptive Signaling to Kinase Inhibition in Cancer Cells (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors (, NA)
• Innate immunity to dengue virus infection and subversion of antiviral responses (, NA)
• Innate immunity to dengue virus infection and subversion of antiviral responses (, NA)
• (Panel A) Effective cancer therapy may require combination treatments (, Homo sapiens,Mus musculus,NA)
• Mechanistic model depicting the factor association of DDB2 and XPC with ATR and ATM, influencing the DDR pathway in response to UV damage (, NA)
• Seven FDA-approved agents for the treatment of kidney cancer targeting the von Hippel–Lindau (VHL) tumour suppressor pathway (, NA)
• Activated STING in a Vascular and Pulmonary Syndrome (, Homo sapiens,Mus musculus,Gallus gallus,Anthela adriana,NA)
• New strategies in Prostate Cancer: targeting lipogenic pathways and the energy sensor AMPK (, Homo sapiens,Mus musculus)
• Putative model for the formation of stable and labile LTM of aversive (fear) and appetitive (drug) stimulus (, NA)
• Ketone bodies as signaling metabolites (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Galatella linosyris,Amniota,Homo sapiens,Sus scrofa)
• ATM/ATR pathways regulate HR and NHEJ in response to oxidative DNA damage (, Xenopus laevis,Calloplesiops altivelis,Homo sapiens,Rattus norvegicus,Helicobacter pylori,Schizosaccharomyces pombe)
• Schematic Overview of Nodal and Cripto-1 Signaling Pathways (, NA)
• Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2 (, NA)
• Intracellular energetic units (ICEUs) (, NA)
• TLR signaling and CXCR4/7 in human liver MDB formation (, NA)
• Intracellular signaling pathways integrate dopamine and glutamate signals (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Transcriptional response to dietary restriction in Drosophila melanogaster (, Drosophila melanogaster,Homo sapiens)
• Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Final summarized parameter ranking according to with respect to (a) tumor volume and (b) tumor expansion rate (, NA)
• Perpetuation of innate immune responses in sJIA (, NA)
• Secretion of IL-1B by monocytes in inflammatory diseases (, NA)
• Intracellular signaling mechanism triggered by CSPG present in the glial scar (, Gallus gallus,Danio rerio,Xenopus laevis,Triportheus paranensis,Uria aalge,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Sus scrofa,Felis catus,Homo sapiens,prion,Arachis hypogaea)
• G protein-coupled receptors as oncogenic signals in glioma: emerging therapeutic avenues (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Listeria monocytogenes)
• Hypothesised mechanism by which the tetrapeptide N-acetyl-seryl-aspartyly-lysyl-proline (Ac-SDKP) inhibits fibrosisAc-SDKP is generated from the G actin binding peptide, thymosin B4, by prolyl oligopeptidase (POP) through one-step enzymatic cleavge (, NA)
• Proposed TLR signaling mechanism by CS14K: a hypothetical model of TLR4 signaling, pathway activated by fusion protein, in a MyD88-independent fashion (, Plasmodium falciparum,Leishmania major,Plasmodium berghei,Plasmodium vivax,Plasmodium yoelii,Anopheles stephensi,Plasmodium yoelii 17,Human immunodeficiency virus 1,unidentified influenza virus,Vaccinia virus,Modified Vaccinia Ankara virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Gallus gallus,Escherichia coli DH5alpha)
• Interferons: Success in anti-viral immunotherapy (, Human immunodeficiency virus 1,Hepatitis B virus,Human papillomavirus,Homo sapiens,Mus musculus,NA)
• Nutrient-induced cell proliferation in the crypt (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Intermediary Metabolism in the Heart (, NA)
• Putative pathway from cAMP to ERK in PACAP-mediated neurite outgrowth in PC12 cells (, NA)
• Diagram depicts a model in which Eya2 and Ebf3 are positioned in the gene regulatory pathway for the development of RGCs (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster,Plasmid pTF1)
• Schematic diagram and proposed model for the metabolic regulation and coordination of the leptin mediated reproductive and nutritional axes (, NA)
• Wnt/Beta-catenin signaling pathway (, NA)
• Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• TLR2-dependent activation of Beta-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation (, Escherichia coli,Mycobacterium tuberculosis,Porphyromonas gingivalis,Francisella tularensis,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Programmed Death-1 Immune Suppressive Pathway: Barrier to Anti-Tumor Immunity (, NA)
• Non-Classical Renin-Angiotensin System and Renal Function (, NA)
• Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression (, NA)
• Specific signaling pathways maintain the resting platelet state (a) or initiate platelet activation (b) (, Homo sapiens)
• CD28 and CTLA-4 coreceptor expression and signal transduction (, NA)
• Schematic representation summarizing the intracellular events involved in the neurotrophic activities of PACAP on PC12 cells (, NA)
• AsTF signaling pathway (, NA)
• MicroRNA Regulation of Smooth Muscle Phenotype (, Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Dermatophagoides farinae)
• MicroRNA Regulation of Smooth Muscle Phenotype (, Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Dermatophagoides farinae)
• RLR signaling pathway showing RIG-I bound to ligand RNA and signaling downstream to IRF-3 and NF-kB to induce IFNA/B production from a virus-infected cell (, NA)
• Schematic illustrating mechanisms of SR-A intracellular signaling (, NA)
• Receptor “hijacking” by malignant glioma cells: a tactic for tumor progression (, Homo sapiens,Mus musculus)
• Control of Hepatic Glucose Metabolism by Islet and Brain (, NA)
• Known and newly proposed pathways for kaempferol’s effect on angiogenesis in ovarian cancer cells (, Fragaria x ananassa,Ginkgo biloba,Homo sapiens,Rattus norvegicus,Bos taurus)
• Germline PTEN Mutation Cowden Syndrome: An Under-Appreciated Form of Hereditary Kidney Cancer (, NA)
• Altered gene expression during pressure overload hypertrophy (, Homo sapiens,Mus musculus)
• Fear circuitry subserving unconditioned and conditioned fear derived from animal data (, Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus)
• This figure illustrates the core TSC-mTor pathway, as discussed in the text (, NA)
• Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets (, Homo sapiens,Mandrillus leucophaeus,Mus musculus,Escherichia coli)
• Entourage: Visualizing Relationships between Biological Pathways using Contextual Subsets (, Homo sapiens,Mandrillus leucophaeus,Mus musculus,Escherichia coli)
• Necroptotic signaling in adaptive and innate immunity (, Vaccinia virus,Murid betaherpesvirus 1,Murine hepatitis virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Autophagy in Cancer: Therapeutic Implications (, NA)
• Simply comparing and contrasting the expression patterns of perturbed genes was inadequate for deciphering the MAPK pathway response dynamics (, NA)
• Model showing the role of AKAP-Lbc in the regulation of cardiac hypertrophy, through the PKD-HDAC5-MEF2 signaling pathway (, NA)
• Schematic diagram illustrating the proposed signaling pathway involved in cigarette smoke extract-induced increase in expressions of inflammatory genes in airway smooth muscle cells (, Mus musculus,Rattus norvegicus,Cavia porcellus,Castor fiber,Cavia magna,Nicotiana tabacum,Ginkgo biloba,Homo sapiens,Canis lupus familiaris,Cereibacter sphaeroides)
• Cell cycle regulatory pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,adeno-associated virus 2)
• Crosstalk between host autophagy and viruses (, Influenza A virus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,unidentified influenza virus,Human betaherpesvirus 5,H1N1 subtype,Human gammaherpesvirus 8,Vesicular stomatitis virus,Enterovirus C,Coxsackievirus B3,Sindbis virus,Tobacco mosaic virus,H3N2 subtype,ssRNA viruses,Murid gammaherpesvirus 4,H9N2 subtype,Saimiriine gammaherpesvirus 2,Hepatitis C virus genotype 1,Aurantiochytrium single-stranded RNA virus 01,Molluscum contagiosum virus,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,NA,NA,NA)
• WNT Signaling in Bone Development and Homeostasis (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• AKAPs: The Architectural Underpinnings of Local cAMP signaling (, NA)
• MicroRNAs in Rheumatoid Arthritis (, NA)
• FOXO3-mTOR Metabolic Cooperation in the Regulation of Erythroid Cell Maturation and Homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Schematic depiction of the role of OGG1-initiated DNA base excision repair in an innate immune response (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,vectors,Calloplesiops altivelis)
• Activation of the transcription factor CREB by the NMDA signal transduction pathway (, NA)
• New Hormonal Therapies for Castration Resistant Prostate Cancer (, NA)
• Schematic diagrams of Wingless and Arm structure, and pathway relationships (, NA)
• Planar Cell Polarity Pathway – Coordinating morphogenetic cell behaviors with embryonic polarity (, Danio rerio,Xenopus laevis,Phoenicopterus roseus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• A Signaling Network Induced by B2 Integrin Controls the Polarization of Lytic Granulesin Cytotoxic Cells (, NA)
• Recent advances in understanding colitis-associated tumorigenesis (, Escherichia coli,Enterococcus faecalis,Bacteroides fragilis,Fusobacterium nucleatum,Citrobacter rodentium,Escherichia coli NC101,Homo sapiens,Mus musculus,gut metagenome)
• Simplified outline of the MyD88-signaling pathway by which TLR agonists induce the production of inflammatory mediators (, Homo sapiens,Mus musculus,Canis lupus familiaris,Dictyostelium discoideum)
• B-cell receptor (BCR) and its downstream pathways (, NA)
• Multiple event model for B-cell lymphomagenesis (, NA)
• Ingenuity canonical pathway analysis (, NA)
• EGFR signalling in chronic lung disease (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Nicotiana tabacum,Pseudomonas aeruginosa)
• Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Nicotiana tabacum,Pseudomonas aeruginosa)
• Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Nicotiana tabacum,Pseudomonas aeruginosa)
• Advances in understanding of bile acid diarrhea (, NA)
• Indian Hedgehog Mediates Gastrin-Induced Proliferation in Stomach of Adult Mice (, Mus musculus,Rattus norvegicus,Phleum pratense,Ulex europaeus,Homo sapiens,Canis lupus familiaris,Helicobacter pylori)
• Tyrosine phosphatase SHP2 is required for the proper timing of neurogenesis and gliogenesis and the balance between them during CNS development (, NA)
• Adaptive resistance to RAF inhibitors in melanoma (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Senescent cells in ageing (, Homo sapiens,Mus musculus,NA)
• PI3K/AKT/mT0R signaling pathway (, Human gammaherpesvirus 4,Rous sarcoma virus,Homo sapiens,Mus musculus)
• Management of Pediatric and Adult Patients with Medulloblastoma (, NA)
• TGFB/SMAD/GLI2 signaling axis in cancer progression and metastasis (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity (, NA)
• Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of innate immunity (, NA)
• An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis (, Candida albicans,Homo sapiens)
• mTOR inhibitors in renal cell carcinoma (, Homo sapiens,Mus musculus)
• Notch pathway (, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Amniota,Homo sapiens,Mus musculus,Thylacinus cynocephalus)
• FLCN pathway (, Homo sapiens,Mus musculus)
• Impact of Genetics on the Diagnosis and Treatment of Renal Cancer (, Homo sapiens,Mus musculus)
• Metabolism and bioactivation of carcinogenic aromatic and heterocyclic amines (, Homo sapiens,Rattus norvegicus,Nicotiana tabacum,Actinobacillus minor,Glires)
• Cartoons of protein C activation and APC signaling in the membrane lipid-rafts of endothelial cells (, Homo sapiens,Mus musculus)
• Cartoons of PAR1 activation by thrombin in the membrane lipid-rafts of endothelial cells when EPCR is free or occupied by its natural ligand (, Homo sapiens,Mus musculus)
• Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation (, Mus musculus,Steatomys pratensis,Homo sapiens)
• Interactions between alcohol-induced mechanisms leading to hepatic carcinogenesis (, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Zea mays,Homo sapiens,NA)
• Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice (, Mus musculus,Rattus norvegicus,Bilophila wadsworthia,Aeromicrobium sp. E12,Homo sapiens,Candida dubliniensis,Trichogramma alpha)
• HIV-1 Replication and Latency Are Regulated by Translational Control of Cyclin T1 (, NA)
• Developmental Pathways Activated in Melanocytes and Melanoma (, NA)
• Developmental Pathways Activated in Melanocytes and Melanoma (, NA)
• Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics (, NA)
• The MAPK/ERK pathway (, NA)
• Sirt1 activity as it relates to AD etiology (, NA)
• NAD+-dependent histone deacetylase (HDAC) activity in relation to gene transcription (, NA)
• IRE1Alpha-XBP1 pathway in glucose homeostasis (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• IRE1Alpha-XBP1 pathway in inflammation (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• IFNA (type-I IFN) and IFN-λ (type-III IFN) signal through distinct receptor complexes, but activate the same intracellular signaling pathway (, NA)
• Resistance to BRAF inhibitors (, NA)
• smicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma (, NA)
• EGF signaling pathway to stimulate proliferation of conjunctival goblet cells (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Staphylococcus aureus,Pseudomonas aeruginosa,Helicobacter pylori,Homo sapiens,Oryctolagus cuniculus,Paracentrotus lividus,Ambrosia artemisiifolia)
• Tear Film Mucins: Front Line Defenders of the Ocular Surface; Comparison with Airway and Gastrointestinal Tract Mucins (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Staphylococcus aureus,Pseudomonas aeruginosa,Helicobacter pylori,Homo sapiens,Oryctolagus cuniculus,Paracentrotus lividus,Ambrosia artemisiifolia)
• Signaling through PI3K/mTOR and Ras/Raf/MEK/ERK pathways is controlled by negative feedback loops (, Homo sapiens,Mus musculus,clinical samples,Cerobasis alpha)
• A) Compensatory over-activation of signal transduction pathways induced by rapamycin-mediated suppression of negative feedback loops (, Homo sapiens,Mus musculus,clinical samples,Cerobasis alpha)
• A) Compensatory over-activation of signal transduction pathways induced by dual PI3K/mTOR inhibitors (, Homo sapiens,Mus musculus,clinical samples,Cerobasis alpha)
• Harnessing Hippo in the heart: Hippo/YAP1 signaling and applications to heart regeneration and rejuvenation (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Neurology of mTOR (, NA)
• Neurology of mTOR (, NA)
• Pathophysiological roles of peroxynitrite in circulatory shock (, NA)
• Generalized schematic of MAP kinase signaling demonstrating the points of pathway activation for cancer models shown to overexpress Mmp1a (, NA)
• Isoprenoid biosynthetic pathway (IBP) and pharmacological inhibitors (, NA)
• Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis (, NA)
• Novel Role of Vascular Endothelial Cadherin in Modulating c-Src Activation and Downstream Signaling of Vascular Endothelial Growth Factor (, NA)
• Resistance to Chemotherapy and Molecularly Targeted Therapies: Rationale for Combination Therapy in Malignant Melanoma (, NA)
• Pathways for initiation and maintenance of psoriasis (, Nicotiana tabacum,Candida albicans,Candida albicans 23R,Candida albicans 23P,Homo sapiens,Mus musculus)
• Biogenesis and Homeostasis of Nicotinamide Adenine Dinucleotide Cofactor (, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Bacillus subtilis,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli K-12,Salmonella enterica,Bacillus subtilis At2,Shigella flexneri,Haemophilus influenzae,Synechocystis sp.,Rhodobacter capsulatus,Yersinia pestis,Thermus thermophilus,Thermotoga maritima,Proteus mirabilis,Stenotrophomonas maltophilia,Archaeoglobus fulgidus,Salmonella enterica subsp. enterica serovar Typhimurium str. LT2,Pyrococcus horikoshii,Arthrobacter sp.,Haemophilus ducreyi,Salmonella enterica subsp. enterica serovar Dublin,Salmonella enterica subsp. enterica,Pseudoalteromonas atlantica,Salmonella bongori,Shigella flexneri 5a,Micrococcus flavus,Hahella chejuensis,Saccharomyces cerevisiae,Arabidopsis thaliana,Bacteriophage sp.,Tequatrovirus T4,Homo sapiens,Bos taurus,unidentified)
• LEARNING CYCLIC SIGNALING PATHWAY STRUCTURES WHILE MINIMIZING DATA REQUIREMENTS (, Homo sapiens)
• Retinoid metabolic pathway (, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Homo sapiens,Mus musculus)
• LEARNING CYCLIC SIGNALING PATHWAY STRUCTURES WHILE MINIMIZING DATA REQUIREMENTS (, Homo sapiens)
• BN and GBN results from synthetic data, using one perturbation per sample (, Homo sapiens)
• More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases (, Homo sapiens,Mus musculus,NA)
• Disseminated cancer cell dormancy: an awakening field (, NA)
• PI-3K/Akt signaling pathway (, NA)
• TGFB signaling during PE cell EMT (, Gallus gallus,Homo sapiens)
• Key signaling nodes in prostate cancer that regulate epithelial plasticity (, Homo sapiens)
• Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential (, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Haemophilus influenzae,Borreliella burgdorferi,Neisseria meningitidis,Streptococcus agalactiae,Streptococcus sp. group B,Escherichia coli 14A,Citrobacter koseri,Human alphaherpesvirus 1,West Nile virus,DNA viruses,dsRNA viruses,Theilers encephalomyelitis virus,Drosophila melanogaster,Toxoplasma gondii,Onchocerca volvulus,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,NA)
• Inflammophilic character of the periodontitis-associated microbiota (, Porphyromonas gingivalis,Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans,Levilactobacillus brevis,Treponema denticola,Tannerella forsythia,Prevotella intermedia,Filifactor alocis,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Oryctolagus cuniculus,human oral metagenome)
• Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa (, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,Enterovirus C,Simian immunodeficiency virus,dsRNA viruses,Homo sapiens,Chlorocebus aethiops,Mus musculus,Xenopus laevis,clinical samples,Vasconcellea candicans)
• Not(ch) just development: Notch signalling in the adult brain (, NA)
• Multiple TYRO3-activated pathways signaling pathways converge with transcription or activation of MITF (reproduced from Mitra et al ()), an oncogenic transcription factor often dysregulated in malignant melanoma (, Homo sapiens,Mus musculus)
• COMPLEMENT REGULATION IN RENAL DISEASE MODELS (, NA)
• Signaling pathways employed by CSCs: Distinct combinations of paracrine and juxtracrine signals induce the EMT in different contexts (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Three Wnt-dependent pathways have been categorized: canonical Wnt/Beta-catenin and non-canonical Wnt/PCP as well as Wnt/Ca2+ pathways (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Gallus gallus,Canis lupus familiaris,Xenopus laevis,Homo sapiens,clinical samples)
• Influence of canonical Wnt signals on the MAPK pathway (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Gallus gallus,Canis lupus familiaris,Xenopus laevis,Homo sapiens,clinical samples)
• Influence of non-canonical Wnt signals on the MAPK pathway (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Gallus gallus,Canis lupus familiaris,Xenopus laevis,Homo sapiens,clinical samples)
• Influence of MAPK signals on the Wnt pathway (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Gallus gallus,Canis lupus familiaris,Xenopus laevis,Homo sapiens,clinical samples)
• Eph Receptor Tyrosine Kinases in Cancer Stem Cells (, NA)
• MICRORNAs IN ER STRESS: DIVERGENT ROLES IN CELL FATE DECISIONS (, NA)
• Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood (, NA)
• Bacterial lifestyle shapes the regulation of stringent response activation (, Escherichia coli,Myxococcus xanthus,Homo sapiens)
• TrkA, TrkB, and TrkC isoform expression and activation (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Disease: The Oxidative Stress Theory of Diabetic Neuropathy (, Mus musculus,Rattus norvegicus,Homo sapiens,Triportheus paranensis,Corynephage beta)
• Post-translational regulation of TGFB receptor and Smad signaling (, NA)
• Molecular mechanisms of epithelial–mesenchymal transition (, NA)
• Smad-dependent and Smad-independent TGFB family signaling (, Mus musculus,Homo sapiens)
• Understanding Intellectual Disability through Rasopathies (, NA)
• Hypothesis of IPC-induced cardioprotection (, Mus musculus,Rattus norvegicus,Armoracia rusticana,Homo sapiens)
• Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Oncolytic Newcastle Disease Virus for cancer therapy: old challenges and new directions (, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Vaccinia virus,Measles morbillivirus,Reovirus sp.,Simian immunodeficiency virus,Ebola virus sp.,Infectious bronchitis virus,Chicken anemia virus,Gallid alphaherpesvirus 1,Newcastle disease virus AF2240,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Canis lupus familiaris,Diaporthe sclerotioides,NA,NA,NA)
• The role of TAK1 signaling in bone metastasis (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis)
• Dynamical constraints on a signaling pathway involved in tissue differentiation in rat correlate with allelic variation at the population level in the same pathway in fruit flies, revealing a link between dynamics and evolution (, NA)
• Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth (, NA)
• Signaling partners of the p75NTR (, NA)
• CHROMOSOMAL INSTABILITY PATHWAY IN COLON CANCER (, NA)
• CHROMOSOMAL INSTABILITY PATHWAY IN COLON CANCER (, NA)
• Interaction of the EGF and TGFB pathways in the control of proliferation in breast cancer (see also ) (, Mus musculus,Rattus norvegicus,Venustaconcha ellipsiformis,Dictyostelium discoideum,Homo sapiens,Axis axis)
• Putative signaling mechanisms for apelin’s regulation of insulin sensitivity (, NA)
• Regulatory cross-talk between the estrogen receptor alpha and MTA family members (, NA)
• NEUROTROPHINS IN THE VENTRAL TEGMENTAL AREA: ROLE IN SOCIAL STRESS, MOOD DISORDERS AND DRUG ABUSE (, NA)
• Neurobiological bases of memory formation: from physiological conditions to psychopathology (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Prolactin-Stimulated Activation of ERK1/2 Mitogen-Activated Protein Kinases is Controlled by PI3-Kinase/Rac/PAK Signaling Pathway in Breast Cancer Cells (, NA)
• B-Myb, Cancer, Senescence, and MicroRNAs (, Human papillomavirus,Avian retroviruses,Homo sapiens,Mus musculus)
• Endocytosis and endosomes at the crossroads of regulating trafficking of axon outgrowth-modifying receptors (, NA)
• Functional pathway analysis of the 12-gene genomic instability signature using Ingenuity Pathway Analysis (, Alburnus alburnus,Gallirallus australis,Homo sapiens,Mus musculus,Sequoia sempervirens)
• Murine model of the multiple actions to suppress immune surveillance of exosomes released from neoplastic cells (, Homo sapiens,Mus musculus)
• Autophagy regulation (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Hepatitis B virus,NA)
• Piwi proteins and piRNAs step onto the systems biology stage (, Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Tetrahymena thermophila,Ascaris suum,Aplysia californica,Caenorhabditis briggsae,Drosophila simulans,Caenorhabditis remanei,Caenorhabditis brenneri,Oxytricha trifallax,Danio rerio,Xenopus tropicalis,Ambystoma mexicanum,Mus musculus,Rattus norvegicus,Schizosaccharomyces pombe,Solanum melongena,Homo sapiens,artificial sequences)
• Müller glia cell reprogramming and retina regeneration (, NA)
• Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond (, NA)
• Simplified diagram illustrating the mTOR signaling pathway (, NA)
• Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond (, NA)
• Targeting RAF kinases for cancer therapy: BRAF mutated melanoma and beyond (, NA)
• Cellular signaling through pre-organized and inter-connected nanocluster assemblies with gel-like properties (, NA)
• Signal transduction pathways integrate activity of multiple cytokines (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Pomacea canaliculata,Homo sapiens,Spinacia oleracea)
• Crosstalk between Mycobacterium tuberculosis and the host cell (, Mycobacterium tuberculosis,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Listeria monocytogenes,Vibrio cholerae,Mycobacterium tuberculosis variant bovis BCG,Bacillus anthracis,Mycolicibacterium smegmatis,Mycobacterium tuberculosis H37Rv,Mycobacterium leprae,Mycobacterium marinum,Moraxella bovis,Vibrio vulnificus,Brucella melitensis,Mycobacterium kansasii,Mycolicibacterium phlei,Komagataeibacter xylinus,Mycobacterium tuberculosis CDC1551,Mycobacterium tuberculosis str. Erdman ATCC 35801,Mycobacterium tuberculosis variant microti,Staphylococcus aureus Rd.3,Murine hepatitis virus,Murine leukemia virus,Rotavirus A,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Disorders of the PI3K-AKT-PTEN pathway (, Homo sapiens,Mus musculus,Panthera pardus,NA)
• Mechanisms underlying DOX-induced cardiotoxicity (, NA)
• Hras-Braf MAP-Kinase pathway visualized using GenMAPP software (, Mus musculus,Rattus norvegicus,Homo sapiens,Zea mays)
• Aldosterone on insulin sensitivity and secretion (, NA)
• HDL and Cognition in Neurodegenerative Disorders (, herbal medicine,Panax ginseng,Ginkgo biloba,Panax notoginseng,Citrus limon,Glycyrrhiza glabra,Crocus sativus,Gardenia jasminoides,Salvia officinalis,Melissa officinalis,Salvia plebeia,Galanthus woronowii,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Chlorocebus aethiops,Oryctolagus cuniculus,Enterovirus C)
• NADPH oxidase- and mitochondria-derived reactive oxygen species pathways in microglial activation (, NA)
• Glutathione peroxidase activity pathway which was significantly altered in the liver of female LMB, obtained from GSEA, featuring GO terms (, NA)
• Proposed model (, Homo sapiens,Mus musculus,Canis lupus familiaris,Candida albicans)
• Classical Complement Pathway affected in the ovary of female LMB (by gene set enrichment analysis (GSEA)) (, NA)
• Crossing Signals: relationships between Beta-adrenergic stimulation and CaMKII activation (, NA)
• Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Mycobacterium tuberculosis,Lareunionomyces loeiensis)
• Wnt5a: A Player in the Pathogenesis of Atherosclerosis and other Inflammatory Disorders (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Mycobacterium tuberculosis,Lareunionomyces loeiensis)
• PROTEASE MEDIATED HUMAN SMOOTH MUSCLE CELL PROLIFERATION BY UROKINASE REQUIRES EPIDERMAL GROWTH FACTOR RECEPTOR TRANSACTIVATION BY TRIPLE MEMBRANE SIGNALING (, NA)
• Embryonic development, organ development, organ morphology, cellular growth and proliferation, cancer, and tumor morphology (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth (, NA)
• Molecular mechanisms that control AII amacrine cell coupling (, Mus musculus,Rattus norvegicus,Danio rerio,Carassius auratus,Homo sapiens,Oryctolagus cuniculus,Olea europaea)
• Munc18c: A Controversial Regulator of Peripheral Insulin Action (, NA)
• Interaction between HCV and Nuclear Receptor-mediated Pathways (, Homo sapiens,Mus musculus,Rattus norvegicus,Hepatitis B virus,Pan troglodytes,Porcine enteric sapovirus,Candida dubliniensis,NA)
• EGFR signaling pathways and receptor cross-talk (, Homo sapiens,Mus musculus,clinical samples)
• Rice innate immunity signaling pathways [,,,] (, NA)
• Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Model illustrating interrelations of insulin, PKCD and arsenite (, NA)
• Schematic depiction of how complement modulates T-cell immunity (, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Rb Pathway and Cancer Therapeutics (, NA)
• Protein and Amino Acid Restriction, Aging and Disease: from yeast to humans (, NA)
• Protein and Amino Acid Restriction, Aging and Disease: from yeast to humans (, NA)
• Anti- and pro-apoptotic roles of RIPK1(A) Upon TNFR-1 ligation (, unidentified influenza virus,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,NA)
• Descending Control of Itch Transmission by the Serotonergic System via 5-HT1A-Facilitated GRP-GRPR Signaling (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus,Gallus gallus,Phytomonas oxycareni)
• Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling (, NA)
• TACE activation by MAPK signaling (, NA)
• ARF6-regulated shedding of tumor-cell derived plasma membrane microvesicles (, Bos taurus,Canis lupus familiaris,Homo sapiens)
• NFKB signaling participates in both Receptor Activator of NFKB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NFKB pathways (, NA)
• A representative immune response pathway that leads to the disruption of viral release from the plasma membrane (, NA)
• Deciphering the Role of Forkhead Transcription Factors in Cancer Therapy (, NA)
• Extensive feedback and feedforward loops between Ras signaling and miRNAs (, NA)
• Control of transcription and miRNA biogenesis by TGFB/BMP signaling (, NA)
• pRB, a Tumor Suppressor with a Stabilizing Presence (, NA)
• Role of soluble adenylyl cyclase in mitochondria (, NA)
• Canonical Wnt/Beta-catenin signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,NA)
• Nitrosothiol signaling and protein nitrosation in cell death (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Plasmacytoid dendritic cell as the Swiss army knife of the immune system: Molecular regulation of their multifaceted functions (, NA)
• A.Genes with altered expression upon miR-224 stimulation are involved in the cell cycle control (, NA)
• Regulation of STEP expression and activity (, NA)
• Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases (, Homo sapiens,Mus musculus,Rattus norvegicus,Pseudomonas aeruginosa,Acinetobacter baumannii,Papio hamadryas,Caenorhabditis elegans)
• Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases (, Homo sapiens,Mus musculus,Rattus norvegicus,Pseudomonas aeruginosa,Acinetobacter baumannii,Papio hamadryas,Caenorhabditis elegans)
• PYRIN domain in signal transduction (, NA)
• Sex hormone biosynthesis and degradation pathway (, NA)
• Schematic illustration of the mTOR signaling pathway, including major upstream regulators and downstream substrates for both the mTORC2 and mTORC1 kinase complexes (, NA)
• Quantitative Analysis of Robustness of Dynamic Response and Signal Transfer in Insulin mediated PI3K/AKT Pathway (, Homo sapiens,Mus musculus,synthetic gene)
• Central role of soluble adenylyl cyclase and cAMP in sperm physiology (, NA)
• Network of HNF4A-regulated genes (, Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Mus musculus,Dipturus trachyderma)
• Network of TP53-regulated genes (, Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Mus musculus,Dipturus trachyderma)
• An example of a cluster illustrating Ras activation (, Homo sapiens,Canis lupus familiaris,Corynebacterium phage gamma)
• TLR4 signaling cascade (, Mus musculus,Rattus norvegicus,Cavia porcellus,Drosophila melanogaster,Cryptosporidium parvum,Homo sapiens)
• TLX: A Master Regulator for Neural Stem Cell Maintenance and Neurogenesis (, NA)
• Comprehensive analysis of the transcriptional response of human decidual cells to lipopolysaccharide stimulation (, Mus musculus,Rattus norvegicus,Homo sapiens,Metamycoplasma hominis)
• Cytokine-Like Factor 1 (CLF1): Life after Development? (, NA)
• ERM proteins are scaffolds for cAMP signaling pathways (, NA)
• Schematic demonstrating the effects of AMPK signaling in stroke (, Drosophila melanogaster,Caenorhabditis elegans,Daphnia pulex,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,NA)
• Pathway alterations involved in the development of low-grade serous carcinoma (, NA)
• Noonan syndrome (, NA)
• Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer (, NA)
• Activation of HER2/ERK/MKP1 pathway in therapy-resistant breast cancer cells (, Homo sapiens,Mus musculus,Glycine max)
• Central LepRb expression sites and related neuronal circuits (, NA)
• Holoprosencephaly: signalling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans (, NA)
• Cross-talk between TLR4 and IL-1 signaling pathways (, Chlamydia trachomatis,Neisseria gonorrhoeae,Gardnerella vaginalis,Homo sapiens,Trichomonas vaginalis)
• Cardioprotective signaling by ischemic and pharmacologic pre-conditioning (PC) and post-conditioning (PoC) (, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Saccharomyces cerevisiae,NA)
• Coordinate Regulation of mRNA Decay Networks by GU-rich Elements and CELF1 (, NA)
• ER activation of mGluRs is organized via caveolins into brain region specific functional microdomains (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Xenopus laevis,Middle East respiratory syndrome-related coronavirus)
• RTK-PI3K-AKT signaling pathway (, NA)
• LPS and cytokines inhibit rat cardiomyocyte contractility in vitro (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Cavia porcellus,Homo sapiens,unidentified)
• Cofilin pathway in breast cancer invasion and metastasis (, Drosophila melanogaster,Homo sapiens)
• Cofilin pathway in breast cancer invasion and metastasis (, Drosophila melanogaster,Homo sapiens)
• This figure shows the VEGF pathway for angiogenesis (, Homo sapiens,Oryctolagus cuniculus,Nicotiana tabacum,Human papillomavirus,Dipturus trachyderma)
• Glucose-TOR-E2Fa signaling regulates the G1 to S transition and promotes cell cycle initiation in meristems (, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Zea mays,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Hordeum vulgare,Sorghum bicolor,Nicotiana benthamiana,Spinacia oleracea,Physcomitrium patens,Spermatophyta,Beet curly top virus,Tomato golden mosaic virus,Homo sapiens,Mus musculus,Campylobacter upsaliensis)
• Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis (, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,herbal medicine,Camellia sinensis,Acinetobacter baumannii,Thermoplasma acidophilum,Homo sapiens,Subgroup C)
• NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease (, NA)
• Regulation of microsomal triglyceride transfer protein (, NA)
• Human spermatogonial stem cells: a possible origin for spermatocytic seminoma (, NA)
• Epigenetic Programming of Hypoxic-Ischemic Encephalopathy in Response to Fetal Hypoxia (, NA)
• Complement in Kidney Disease: Core Curriculum 2015 (, Mus musculus,Oryctolagus cuniculus,Ovis aries,Cavia porcellus,Homo sapiens,Escherichia coli O104H4,Sesbania grandiflora)
• KEGG pathways significantly associated with NPG (, Mouse mammary tumor virus,Enterovirus C,Subgroup A,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Lareunionomyces loeiensis,Venustaconcha ellipsiformis)
• Butanonate metabolic pathway (KEGG pathway hsa00650) (, Mouse mammary tumor virus,Enterovirus C,Subgroup A,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Lareunionomyces loeiensis,Venustaconcha ellipsiformis)
• The Wsp signal transduction pathway (, Escherichia coli,Pseudomonas aeruginosa,Bacillus subtilis,Vibrio cholerae,Pseudomonas aeruginosa PAO1,Myxococcus xanthus,Azotobacter vinelandii,Azospirillum brasilense,Shewanella oneidensis MR-1,Azospirillum lipoferum,Rhodospirillum centenum,Azospirillum sp.,Homo sapiens,Mus musculus)
• Rab11-mediated trafficking in host-pathogen interactions (, NA)
• Cellular and metabolic functions for autophagy in cancer cells (, NA)
• Targeting the PI3K pathway for cancer therapy (, NA)
• Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling (, Homo sapiens,Mus musculus)
• Ethanol metabolism pathway (, NA)
• IL-33/ST2 pathway: therapeutic target and novel biomarker (, Drosophila melanogaster,Leishmania major,Schistosoma mansoni,Nippostrongylus brasiliensis,Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• IL-33/ST2 pathway: therapeutic target and novel biomarker (, Drosophila melanogaster,Leishmania major,Schistosoma mansoni,Nippostrongylus brasiliensis,Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• IL-33/ST2 pathway: therapeutic target and novel biomarker (, Drosophila melanogaster,Leishmania major,Schistosoma mansoni,Nippostrongylus brasiliensis,Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Resistance to Diet-Induced Obesity in Mice with Synthetic Glyoxylate Shunt (, Mus musculus,Rattus norvegicus,Escherichia coli,Bacillus sp. in firmicutes,Homo sapiens,Bos taurus,Diaporthe sclerotioides,synthetic gene)
• IPA functional pathway analysis (, NA)
• Endothelin-1 enhances the expression of the androgen receptor via activation of the c-Myc pathway in prostate cancer cells (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Signal transduction mechanisms regulating early, adhesion-independent, and late, adhesion-dependent neutrophil ROS generation (, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Aspergillus fumigatus)
• Molecular Targeted Approaches in Mantle Cell lymphoma (, Homo sapiens,Mus musculus,Iris germanica)
• Molecular Targeted Approaches in Mantle Cell lymphoma (, Homo sapiens,Mus musculus,Iris germanica)
• New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication (, Human betaherpesvirus 5,Human gammaherpesvirus 8,Betapolyomavirus macacae,Murid betaherpesvirus 1,Homo sapiens,Cerobasis alpha,NA)
• New Cell-Signaling Pathways for Controlling Cytomegalovirus Replication (, Human betaherpesvirus 5,Human gammaherpesvirus 8,Betapolyomavirus macacae,Murid betaherpesvirus 1,Homo sapiens,Cerobasis alpha,NA)
• Virus reactivation: a panoramic view in human infections (, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Human alphaherpesvirus 1,unidentified influenza virus,Human betaherpesvirus 5,Adeno-associated virus,Human gammaherpesvirus 8,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Human alphaherpesvirus 3,Polyomavirus sp.,Human betaherpesvirus 6,Merkel cell polyomavirus,Human parvovirus B19,Betapolyomavirus hominis,JC polyomavirus,Human betaherpesvirus 7,Bovine alphaherpesvirus 1,Human betaherpesvirus 6A,Human betaherpesvirus 6B,Artichoke latent virus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,NA)
• Procession to Pediatric Bacteremia and Sepsis: A Series of Covert Operations and Failures in Diplomacy (, NA)
• Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Proposed biosynthetic pathway of diphthamide (, NA)
• PI3K-AKT-mTOR signalling pathway and associated hamartoma/overgrowth syndromes (PI3K subsumes PIK3CA and PIK3R2, AKT subsumes AKT1-3) (, NA)
• IL-23-IL-17 immune axis: Discovery, Mechanistic Understanding, and Clinical Testing (, Diaporthe sclerotioides,Candida albicans,Candida albicans 23R,Escherichia coli,Helicobacter hepaticus,Homo sapiens,Mus musculus,Saimiriine gammaherpesvirus 2,NA)
• TGF-beta signaling pathways (, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus,Human rhinovirus sp.)
• Alterations of the Smad dependent TGF-beta pathways in Cancer (, NA)
• Possible mechanisms that sorafenib and PI-103 differentially inhibits and activates key kinases in the Ras/Raf/MAPK and PI3K/AKT/mTOR pathways (, NA)
• Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway (, Homo sapiens,Mus musculus)
• Atf1-Pcr1-M26 Complex Links Stress-activated MAPK and cAMP-dependent Protein Kinase Pathways via Chromatin Remodeling of cgs2+ (, Schizosaccharomyces pombe)
• Signaling pathway leading to signal transducer and activator of transcription (STAT)-3 activation (see text for definitions of abbreviations) (, Human immunodeficiency virus 1,Human gammaherpesvirus 8,Saimiriine gammaherpesvirus 2,Subgroup A,Human T-cell lymphotropic virus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Nicotiana tabacum,NA)
• Roles of NFKB-mediated inflammatory pathway in cellular transformation, cancer survival, proliferation, invasion, angiogenesis and metastasis (, Homo sapiens)
• GSK-3 family as therapeutic target for myocardial diseases (, NA)
• Hypoxia and the extracellular matrix: drivers of tumour metastasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Key role of transient receptor potential melastatin-2 channels in amyloid-Beta-induced neurovascular dysfunction (, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Hypoxia regulates other critical pathways that impact tumor progression in a HIF-independent fashion (, Homo sapiens)
• Membrane dynamics and the endocytic pathway (, NA)
• SDF-1 signaling via the CXCR4-TCR heterodimer requires PLCB3 and PLCG1 for distinct cellular responses (, NA)
• Schematic diagram describing Src regulation by trafficking (, NA)
• Nicotine signal transduction pathways (, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Nicotiana tabacum,Homo sapiens)
• Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk (, Homo sapiens,Rattus norvegicus,Diaporthe sclerotioides,Major minor)
• Regulation of endonuclease activity in human nucleotide excision repair (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Pyrococcus furiosus,Tequatrovirus T4)
• Signal transduction pathway of bitter (T2R), sweet (T1R2/3), and umami (T1R1/3) GPCRs in type II taste cells of the tongue (, NA)
• Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes (, Homo sapiens,Mus musculus,Bos taurus)
• PI3K-Rac1 signaling that determine sites of neurite formation from the cell body (, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Listeria monocytogenes)
• Epstein-Barr virus Associated B-cell lymphomas: Pathogenesis and Clinical Outcomes (, Human gammaherpesvirus 4,Human papillomavirus,Human gammaherpesvirus 8,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• Regulation of Wnt canonical and calcium-dependent pathway molecules in microstructured Ti surfaces (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Xenopus laevis)
• ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock (, NA)
• Molecular mechanisms in hereditary cancer (, NA)
• Biomarkers Linking PCB Exposure and Obesity (, Homo sapiens,Mus musculus,Eragrostis tef)
• HNSCC tumor microenvironment (, NA)
• Cell Signaling Pathways Involved in Hematopoietic Stem Cell Specification (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,unidentified)
• Proposed dysregulated miR-125b-1 signal pathway involved in SCC (, Homo sapiens,Bos taurus,Oryctolagus cuniculus,Capra hircus,Macaca mulatta,Pan troglodytes,Mus musculus,Human papillomavirus)
• Diversity and specificity: auxin perception and signaling through the TIR1/AFB pathway (, NA)
• Analysis of p53 target genes in melanocytes treated with Nutlin-3 for 18 h (, NA)
• Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,Adeno-associated virus)
• Estrogen Receptor-alpha 36 Mediates the Anti-apoptotic Effect of Estradiol in Triple Negative Breast Cancer Cells via a Membrane-Associated Mechanism (, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Armoracia rusticana,vectors)
• Ethanol signaling pathway that initiates neural crest apoptosis (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana,NA)
• Chemical ‘Jekyll and Hyde’s: Small-molecule inhibitors of developmental signaling pathways (, NA)
• Advances in Understanding the Peptide Neurotransmitter NAAG and Appearance of a New Member of the NAAG Neuropeptide Family (, NA)
• Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Schematic diagram demonstrating the role of RKIP in the regulation of tumor cell drug/immune resistance (black lines) (, Homo sapiens,Mus musculus)
• Convergence of mTORC1 and GSK3B in LPS-stimulated cells (, NA)
• Invited Review MC1R, Eumelanin and Pheomelanin: their role in determining the susceptibility to skin cancer (, NA)
• A) Recent studies describe a complex network of cell-cell signaling that controls the spatiotemporal pattern of RD gene expression during eye development (, NA)
• Hypothetical model for cross-talk of PI3K/AKT with HIV-1-induced STAT1 signaling (, Human immunodeficiency virus 1,Human immunodeficiency virus,Human immunodeficiency virus 2,Homo sapiens,Ulex europaeus)
• Central role of NMPRTase (Nampt*) in the salvage pathway for NAD biosynthesis and related cellular functions (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Canonical WNT signalling regulates mesenchymal stem cell fate (, NA)
• Regulation of protein synthesis through the mTOR signaling pathway by amino acids and insulin (, Bos taurus,Sus scrofa,Homo sapiens,Rattus norvegicus)
• HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism (, NA)
• Schemes of metabolite 13C labeling patterns as a result of [U13C]glucose (Panel A) or [U13C]AcAc (Panel B) infusions (, Mus musculus,Rattus norvegicus,Homo sapiens)
• mTOR signaling cascade in the pathogenesis and prevention of skin cancer (, NA)
• Roles of F-box proteins in cancer (, Homo sapiens)
• COX-2 pathway plays a critical role in angiogenesis, inflammation and cancer () (, Mus musculus,Rattus norvegicus,Cavia porcellus,Saccharomyces cerevisiae,PX clade,Homo sapiens)
• Natural killer cells and regulatory T cells in early pregnancy loss (, Mus musculus,Rattus norvegicus,Equus caballus,Eutheria,Homo sapiens,cellular organisms,Vigna unguiculata subsp. cylindrica)
• Extracellular Hsp90 mediates an NFKB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment (, NA)
• HER2-Positive Breast Cancer: Current Management of Early, Advanced, and Recurrent Disease (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Collagen XIA1 in cancer promotion (, Homo sapiens,Mus musculus,Nicotiana tabacum,NA)
• Toll-like receptor (TLR), nucleotide-binding oligomerization domain (NOD)-like receptor (NLR), and retinoic acid-inducible gene (RIG-I)-like receptor (RLR) signaling (, NA)
• Therapeutic targeting of cancers with loss of PTEN function (, Homo sapiens,Mus musculus,NA)
• Janus Kinase-3 Dependent Inflammatory Responses in Allergic Asthma (, Mus musculus,Rattus norvegicus,Homo sapiens,Respiratory syncytial virus)
• Global gene expression profile and non-canonical transcriptome networks in human breast cancer cell lines (, NA)
• Multiplexed luciferase reporter and biochemical platform for fingerprinting molecular libraries (, NA)
• Therapeutic Targeting of Autophagy: Potential and Concerns in Treating Cardiovascular Disease (, NA)
• Cytosolic nucleic acid pattern recognition and activation of ISGs (, NA)
• Unusual Case of Porcupine (, NA)
• Rise of regulatory RNA (, NA)
• Grueneberg Ganglion olfactory subsystem employs a cGMP signaling pathway (, NA)
• MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy (, NA)
• Macrophage immunoregulatory pathways in tuberculosis (, Mycobacterium tuberculosis,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mycolicibacterium smegmatis,Mycobacterium tuberculosis H37Rv,Mycobacterium avium,Mycobacterium leprae,Mycobacterium tuberculosis H37Ra,Mycolicibacterium phlei,Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Human gammaherpesvirus 8,Homo sapiens,Mus musculus,Rattus norvegicus,Danio rerio,Macaca mulatta,Gallinago media,Bos taurus,Candida dubliniensis)
• Biology of Castrate Resistant Prostate Cancer (, Homo sapiens,Mus musculus)
• Remodelling the extracellular matrix in development and disease (, Xenopus laevis,Homo sapiens)
• Remodelling the extracellular matrix in development and disease (, Mus musculus,Rattus norvegicus,Heterocephalus glaber,Xenopus laevis,Crotalus atrox,Homo sapiens,Sus scrofa,gut metagenome)
• Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy (, NA)
• BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells (, Bos taurus,Capra hircus,Ovis aries,Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus)
• BMolecular Pathways: Novel Approaches for Improved Therapeutic Targeting of Hedgehog Signaling in Cancer Stem Cells (, Bos taurus,Capra hircus,Ovis aries,Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus)
• Regulation by zinc of the ERK1/2 signaling cascade (, NA)
• Proposed signalling pathway involved in the cardiac remodelling process in the absence of natriuretic peptide receptor-A (NPRA)/cGMP signalling (, NA)
• Specificity in neuronal activity-regulated gene transcription (, NA)
• Proposed molecular pathways in arterial, venous and lymphatic specification in a developing embryo (, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Bos taurus)
• Rapid membrane receptor mediated mechanisms for enhancing memory by estradiol (, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Agaricus bisporus,Taeniopygia guttata,Neoclanis basalis)
• Ammoniagenesis (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis,Non-A non-B hepatitis virus,Kurzia media)
• Insulin signal transduction pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Drug targets downstream of receptor tyrosine kinases involved in synovial sarcoma (RTK) (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Activation of Beta-catenin Signaling by TFF1 Loss Promotes Cell Proliferation and Gastric Tumorigenesis (, NA)
• Molecular Pathways: Linking Tumor Microenvironment to Epithelial–Mesenchymal Transition in Metastasis (, NA)
• Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I (, Mus musculus,Rattus norvegicus,Armoracia rusticana,Matthiola incana,Homo sapiens,Bos taurus)
• G protein-coupled receptors — recent advances (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Dipturus trachyderma)
• CXCL12 is highly expressed in tissues like lungs, liver, and bone marrow and is also secreted by tumor and stromal cells (, NA)
• Both ligands and receptors are single-pass transmembrane proteins composed of different structural domains (, NA)
• Transgenic Mouse Models for Alcohol Metabolism, Toxicity and Cancer (, NA)
• Functional network of ion channels in T lymphocytes (, NA)
• Differentially expressed gene enrichment of the top scored pathway maps (, NA)
• Microbiota modulation of myeloid cells in cancer therapy (, Staphylococcus aureus,Helicobacter pylori,Listeria monocytogenes,Clostridioides difficile,Limosilactobacillus fermentum,Candidatus Arthromitus sp. SFB-mouse,Clostridioides difficile CD8,Escherichia coli K1,Homo sapiens,Mus musculus,gut metagenome,unidentified influenza virus)
• CREB and the CRTC co-activators: sensors for hormonal and metabolic signals (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae)
• Metabolic mystery: Aging, obesity, diabetes and ventromedial hypothalamus (, NA)
• SF-induced alteration of common metabolic pathway in liver of 24 h rats (, Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Drosophila melanogaster,Zea mays)
• Therapeutic targets for treating fibrotic kidney diseases (, NA)
• Thiamine Deficiency-mediated Brain Mitochondrial Pathology in Alaskan Huskies with mutation in SLC19A3.1 (, Bos taurus,Canis lupus familiaris,Felis catus,Mustela lutreola,Panthera leo,Rangifer tarandus,Phoca vitulina,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Salvelinus namaycush)
• Biology of Advanced Uveal Melanoma and Next Steps for Clinical Therapeutics (, NA)
• mGluR1/5 signaling pathways relevant to protein synthesis (, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Agaricus bisporus)
• TLR4/NFKB signalling pathway and TLR4/ MAPK signalling pathway in gastrointestinal epithelium (, NA)
• Post-transcriptional gene suppression mediated by miRNAs is involved in the fine-tuning of epithelial anti-Cryptosporidium defence (, NA)
• Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1A Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression (, NA)
• Small-molecule inhibitors of the PI3K signaling network (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Mouse mammary tumor virus)
• Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry (, Nicotiana tabacum,Diaporthe sclerotioides,Olea europaea,Syzygium aromaticum,Mus musculus,Cricetulus griseus,Dipturus trachyderma,Calloplesiops altivelis,Homo sapiens,Oryctolagus cuniculus,Human adenovirus 5)
• Analysis of Individual Molecular Events of DNA Damage Response by Flow and Image Assisted Cytometry (, Nicotiana tabacum,Diaporthe sclerotioides,Olea europaea,Syzygium aromaticum,Mus musculus,Cricetulus griseus,Dipturus trachyderma,Calloplesiops altivelis,Homo sapiens,Oryctolagus cuniculus,Human adenovirus 5)
• Summary of the extracellular interactions between Wnts, Wnt receptors and Wnt regulatory proteins (, Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Accredited translational medicine centre: Human renal fibrotic disease: Translational research at the Center for Cell Biology and Cancer Research (CCBCR), Albany Medical College, Albany, NY (, NA)
• TGF-Alpha-IL-1A/Beta-IL-1ra autocrine cascade contributes to TNF-induced hepatocyte proliferation and Adv-infection sensitized apoptosis through the regulation of multiple shared signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Neural Regulation of CNS Angiogenesis During Development (, Gallus gallus,Danio rerio,Coturnix coturnix,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Key signaling pathways involved in nicotine plus HFD-induced hepatocellular apoptosis (, NA)
• Autophagy in immunity and inflammation (, NA)
• The PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays (, H9N2 subtype,H15N2 subtype,H11N3 subtype,H14N3 subtype,H10N3 subtype,H11N2 subtype,H12N3 subtype,H9N4 subtype,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Pentose phosphate pathway and cancer (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Vicia faba,Homo sapiens,NA)
• Ketamine affects the neurogenesis of rat fetal neural stem progenitor cells via the PI3K/Akt-p27 signaling pathway (, NA)
• Possible pathways to androgen independence and the involvement of ANG (, NA)
• Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection (, NA)
• Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection (, NA)
• Negative regulation of the autophagy pathway (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Xenopus laevis,Enterovirus C,NA,NA)
• Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to the Tumor Immunologists (, Homo sapiens,Mus musculus,Staphylococcus aureus,Human papillomavirus type 16)
• Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to the Tumor Immunologists (, Homo sapiens,Mus musculus,Staphylococcus aureus,Human papillomavirus type 16)
• Mycobiota: interactions between commensal fungi and the host immune system (, NA)
• Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Notch receptors (Notch1-4) and ligands (DLL1, 3 and 4, Jagged 1-2) are expressed in tumor, normal, and endothelial cells (, NA)
• Intrinsic and extrinsic apoptotic pathways (, Homo sapiens,Mus musculus,Ovis aries,Human T-cell leukemia virus type I,NA)
• PRb/E2F pathway regulates cell cycle progression (, NA)
• The functions of the peripheral lamina and the nucleoplasmic LAP2Alpha-lamin A/C complex in the regulation of the pRb/E2F pathway in non-proliferating and proliferating cells (, NA)
• MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells (, NA)
• Pathogenesis of HCC and targets for chemopreventive agents (, Diaporthe sclerotioides,Arachis hypogaea,Curcuma longa,Homo sapiens,Mus musculus,Helicobacter pylori,Hepatitis B virus,NA)
• Theoretical model for metabolism of alcohol in the brain (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Gallus gallus,Hepatitis B virus)
• Death and dessert: Nutrient signalling pathways and ageing (, NA)
• Spatio-temporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio,Escherichia phage T7)
• Molecular model of extranuclear functions of PV in promoting thyroid carcinogenesis via the integrin-FAK-cSrc signaling cascade (, Homo sapiens,Mus musculus)
• How p-CREB acts as a common downstream effector for multiple signaling pathways that regulate BCRP mRNA expression Xie, et.al (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Proposed signaling pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Daucus carota)
• Sensing viral RNAs by Dicer/RIG-I like ATPases across species (, NA)
• Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,gut metagenome,Matthiola incana,clinical samples,Homo sapiens,Mus musculus,Hepatitis B virus,Calloplesiops altivelis,NA)
• Progesterone action in breast, uterine, and ovarian cancers (, NA)
• Progesterone action in breast, uterine, and ovarian cancers (, NA)
• Roles of Microphthalmia Transcription Factor and pigmentation in melanoma (, Homo sapiens,Mus musculus,Danio rerio)
• Manufacturing neurons from human embryonic stem cells: biological and regulatory aspects to develop a safe cellular product for stroke cell therapy (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Choline metabolism in malignant transformation (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Canis lupus familiaris,Brassica oleracea,Homo sapiens,Bacillus cereus,Cerobasis alpha)
• Maintenance of initiated cross bridge-cycling (by Ca2+/MLCK/phosphorylated-MLC20 or p-MLC20) in the sustained smooth muscle contraction or the basal myogenic tone depends on the mechanisms that inhibit MLCP (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Respiratory syncytial virus)
• Choline metabolism in malignant transformation (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Canis lupus familiaris,Brassica oleracea,Homo sapiens,Bacillus cereus,Cerobasis alpha)
• Choline metabolism in malignant transformation (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Canis lupus familiaris,Brassica oleracea,Homo sapiens,Bacillus cereus,Cerobasis alpha)
• Inflammasome activation and cross-talk between endothelial cells (ECs) and macrophages (MØ) in atherogenesis (, NA)
• The proposed regulatory pathway (, NA)
• Essential role of evasion from cell death in cancer (, Homo sapiens,Mus musculus)
• Unfolded Protein Response in Retinal Vascular Diseases: Implications and Therapeutic Potential Beyond Protein Folding (, NA)
• Unfolded Protein Response in Retinal Vascular Diseases: Implications and Therapeutic Potential Beyond Protein Folding (, NA)
• Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells (, NA)
• The Role of the Protein Tyrosine Phosphatase SHP2 in Cardiac Development and Disease (, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Panthera pardus)
• Regulatory Mechanisms of Tumor Suppressor P16INK4A and Relevance to Cancer (, Homo sapiens)
• Autophagy and the integrated stress response (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Mycobacterium tuberculosis)
• Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Nicotiana tabacum,Brassica oleracea,Brucea javanica,Homo sapiens,Gallus gallus,Helicobacter pylori)
• UPR, autophagy and mitochondria crosstalk underlies the ER stress response (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Wnt/Beta-catenin and Notch signaling pathways and pathway crosstalk as illustrated herein (, NA)
• Sulf regulation of Wnt signaling (, Human papillomavirus,Mouse mammary tumor virus,Moloney murine leukemia virus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Nicotiana tabacum,Coturnix coturnix,Homo sapiens)
• Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development (, NA)
• Wnt and FGF mediated epithelial mesenchymal crosstalk during lung development (, NA)
• IQGAPs choreograph cellular signaling from the membrane to the nucleus (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Xenopus laevis)
• Input overload: contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis (, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Tetrapoda,Amniota,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Deuterostomia)
• Endocardial Fibroelastosis is Caused by Aberrant Endothelial to Mesenchymal Transition (, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Human betaherpesvirus 5,Homo sapiens,vectors,NA)
• PI3-K-AKT signaling pathway (, NA)
• HIF Transcription Factors, Inflammation, and Immunity (, Human immunodeficiency virus 1,Staphylococcus aureus,Pseudomonas aeruginosa,Hepatitis B virus,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Streptococcus sp. group A,Streptococcus sp. group B,Homo sapiens,Mus musculus)
• Phosphortlated Smad3 is stabilized by ERG in prostate cells (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana,vectors)
• wRAPping up early monocyte and neutrophil recruitment in atherogenesis via AnnexinA1/FPR2 signaling (, Homo sapiens,Mus musculus)
• A) Diagram of the preparatory and pay-off phases in glycolysis (, NA)
• Muscle KATP Channels: Recent Insights to Energy Sensing and Myoprotection (, NA)
• Phagosome maturation during the removal of apoptotic cells: receptors lead the way (, Saccharomyces cerevisiae,Candida dubliniensis,Eucalyptus intertexta,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Danio rerio,Staphylococcus aureus)
• Signaling-mediated Regulation of MicroRNA Processing (, NA)
• Schematic representation for the role of Alpha-toxin in the inhibition of macrophage apoptosis by S (, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus caballus,Equus asinus,Armoracia rusticana,Matthiola incana,Raphanus sativus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Mus musculus)
• Schematic representation of the sphingolipids metabolic pathway (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Cryptococcus neoformans)
• Molecular events in the autophagy pathway (, NA)
• Pathway analyses of direct interactions among transcripts mediated by P4 in the ovary (, NA)
• Pathway analyses of A) tumor protein p53 (TP53) B) E2F transcription factor 1 (E2F1), and C) miRNA 124-1 (, NA)
• NFKB and STAT3 in Glioblastoma: Therapeutic Targets Coming of Age (, Mus musculus,Rattus norvegicus,Homo sapiens,Phleum pratense,Alburnus alburnus)
• Systems pharmacology assessment of the 5-fluorouracil pathway (, Homo sapiens,Mus musculus,Bos taurus,Matthiola incana,clinical samples,Moloney murine leukemia virus)
• Systems pharmacology assessment of the 5-fluorouracil pathway (, Homo sapiens,Mus musculus,Bos taurus,Matthiola incana,clinical samples,Moloney murine leukemia virus)
• Regulation of sonic hedgehog expression by integrin B1 and epidermal growth factor receptor in intestinal epithelium (, NA)
• Bmp Signaling in Congenital Heart Disease: New Developments and Future Directions (, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pathway for the synthesis of the endocannabinoids AEA and 2-AG (, NA)
• MTOR pathway is regulated by numerous upstream pathways, typically in response to growth factors (anabolic) or energy/nutrient deficiency (cell static or catabolic) (, NA)
• Glutamate homeostasis in a PFC-NAc excitatory synapse in a yoked saline rat (, Mus musculus,Rattus norvegicus,Homo sapiens,Phaseolus vulgaris,Lyssavirus rabies,NA)
• Polymicrobial synergy and dysbiosis in inflammatory disease (, Staphylococcus aureus,Porphyromonas gingivalis,Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans,Treponema denticola,Tannerella forsythia,Prevotella intermedia,Streptococcus gordonii,Streptococcus mitis,Peptostreptococcus stomatis,Filifactor alocis,Streptococcus cristatus,Homo sapiens,Mus musculus,Rattus norvegicus,gut metagenome,Macaca fascicularis,human oral metagenome,Oryctolagus cuniculus,Triportheus paranensis)
• Polymicrobial synergy and dysbiosis in inflammatory disease (, Staphylococcus aureus,Porphyromonas gingivalis,Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans,Treponema denticola,Tannerella forsythia,Prevotella intermedia,Streptococcus gordonii,Streptococcus mitis,Peptostreptococcus stomatis,Filifactor alocis,Streptococcus cristatus,Homo sapiens,Mus musculus,Rattus norvegicus,gut metagenome,Macaca fascicularis,human oral metagenome,Oryctolagus cuniculus,Triportheus paranensis)
• Systematic identification of signaling pathways with potential to confer anticancer drug resistance (, NA)
• Treatment of heterotopic ossification through remote ATP hydrolysis (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens)
• Genome-Wide Meta-Analyses of Plasma Renin Activity and Concentration Reveal Association with the Kininogen 1 and Prekallikrein Genes (, Malus domestica,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Functional consequences of bidirectional promoters (, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Schizosaccharomyces pombe,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhi,Escherichia coli FBP1,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus)
• Drugging the undruggable Ras: mission possible? (, NA)
• Hedgehog signaling in skin cancers (, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Drosophila melanogaster,NA)
• Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (, NA)
• Advances in therapeutic development for spinal muscular atrophy (, Homo sapiens,Mus musculus,Danio rerio,H4N4 subtype)
• Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular disease (, NA)
• BiP and its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions (, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Yarrowia lipolytica,Bos taurus,Oryctolagus cuniculus,Gallus gallus,Danio rerio,Canis lupus familiaris,Xenopus laevis,Mus musculus,Drosophila melanogaster,Caenorhabditis elegans,Cricetus cricetus,Homo sapiens,Escherichia coli,Adeno-associated virus)
• ENGULFMENT OF APOPTOTIC CELLS BY MACROPHAGES: A ROLE OF MICRO-RNA-21 IN THE RESOLUTION OF WOUND INFLAMMATION (, Homo sapiens,Mus musculus,Bos taurus)
• Activation of RTKs and downstream signaling cascades (, NA)
• Oncogenic ras-induced senescence is mediated by sequential activation of the Raf- MAPK/extracellular signal-regulated kinase kinase (MEK)-extracellular signal-regulated kinases (ERK) and mitogen-activated protein kinase kinase (MKK)3/6-p38 pathways (, NA)
• Human prostate cancer vaccines – proposed mechanisms of action and future combinatorial treatment strategies (, Vaccinia virus,Human adenovirus 5,Variola virus,Fowlpox virus,Canarypox virus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Genomic analysis of metastatic cutaneous squamous cell carcinoma (, NA)
• Regulation of Protease-activated Receptor Signaling by Posttranslational Modifications (, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Cartoons of PAR-1-dependent signaling by APC and thrombin in endothelial cells when EPCR is either free or occupied by protein C (, NA)
• Notch signaling pathway.(a) Schematic depiction of mammalian Notch receptors and DSL ligands (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lavandula angustifolia)
• A gene network shows that mRNA levels of PDGFR and ECM-related genes are significantly correlated in human breast cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• The pro- and anti-inflammatory functions of pulmonary collectins in macrophages (, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Pneumocystis murina,Homo sapiens,Bos taurus,Allogromia sp. A)
• Human splicing code reveals new insights into the genetic determinants of disease (, NA)
• Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons (, NA)
• ERK-dependent signalling during conditioning and extinction of fear (, NA)
• PGE2 inhibits IL-10 production via EP2-mediated Beta-arrestin signaling in neuroinflammatory condition (, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Escherichia coli O111B4)
• An extended signaling pathway that regulates basal P-glycoprotein activity at the blood-brain barrier (, NA)
• Ion transporters in brain tumors (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens)
• BMP receptor mediated pathways (, Bos taurus,Oryctolagus cuniculus,Ovis aries,Dipturus trachyderma,Mycteroperca microlepis,Homo sapiens,Armoracia rusticana)
• MITOCHONDRIAL DISEASES PART I: MOUSE MODELS OF OXPHOS DEFICIENCIES CAUSED BY DEFECTS ON RESPIRATORY COMPLEX SUBUNITS OR ASSEMBLY FACTORS (, NA)
• Coexistence of Two Forms of LTP in ACC Provides a Synaptic Mechanism for the Interactions between Anxiety and Chronic Pain (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Novel therapeutic approaches for inclusion body myositis (, NA)
• Schematic illustrating that AMPH indirectly stimulates dopamine (DA), glutamate (glu) and BDNF (B) release and stimulation of D1 dopamine, glutamate, and TrkB receptors, respectively, in the striatum (, NA)
• Induced regulatory T cells in inhibitory microenvironments created by cancer (, Homo sapiens,Mus musculus)
• Signal transduction pathways from the cell membrane to the nucleus discussed in this article (, NA)
• Natural Selection in a Bangladeshi Population from the Cholera-Endemic Ganges River Delta (, Bos taurus,Escherichia coli,Oryctolagus cuniculus,Vibrio cholerae,Eutheria,Vibrio cholerae O1,Homo sapiens,Mus musculus,Drosophila melanogaster,Bacteriophage sp.,NA)
• Macrophages as a Battleground for Toxoplasma Pathogenesis (, Homo sapiens,Mus musculus,Felis catus,Toxoplasma gondii)
• RNA polymerase II transcription complex (, NA)
• IL-1 and TLR activation pathways (, NA)
• TNFA and TCR activation pathways (, NA)
• Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications (, NA)
• Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids (, NA)
• Intracellular signaling proposed to be involved in the inflammatory response during immune-mediated joint diseases such as aseptic loosening (, Homo sapiens,Mus musculus,Drosophila melanogaster,Canis lupus familiaris,Lareunionomyces loeiensis,Mouse mammary tumor virus,Cyprinus carpio)
• Simplified overview of the RA-associated inflammation-promoting factors (, Homo sapiens,Mus musculus,Drosophila melanogaster,Canis lupus familiaris,Lareunionomyces loeiensis,Mouse mammary tumor virus,Cyprinus carpio)
• Chemoattractant signaling pathways in Dictyostelium discoideum (, NA)
• Canonical Rho GTPase signaling motifs regulate actin cytoskeletal dynamics (, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Human papillomavirus type 16,Vaccinia virus,Enterovirus C,Measles morbillivirus,Tobacco mosaic virus,African swine fever virus,Potato virus X,Avian leukosis virus,Tomato bushy stunt virus,Mason-Pfizer monkey virus,Autographa californica nucleopolyhedrovirus,Coxsackievirus A9,Mus musculus,Rattus norvegicus,Gallus gallus,Calloplesiops altivelis,Homo sapiens,NA,NA)
• Schematic diagram illustrating intracellular signaling pathways in a macrophage involved in cytokine regulation by adrenergic and cholinergic agonists and receptors following lipopolysaccharide challenge (, NA)
• Epigenetic mechanisms in cognition (, NA)
• Serum response factor pathway (, Homo sapiens,Mus musculus,Canis lupus familiaris,Rat sarcoma virus)
• Serum response factor pathway in myelopoiesis and myelodysplasia with 5q abnormality (, Homo sapiens,Mus musculus,Canis lupus familiaris,Rat sarcoma virus)
• Working model of signaling pathways to hypoxia-induced phrenic motor plasticity (, NA)
• Which FGF ligands are involved in lens induction? (, NA)
• Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression (, NA)
• Sphingosine-1-phosphate receptor 2: a novel bile acid receptor and regulator of hepatic lipid metabolism? (, Homo sapiens,Mus musculus)
• Pathway analysis links the differentially expressed gene signatures of the MED29 transduced Hs 700T and MIAPaCa-2 cells to a cellular network involved in cell cycle, cancer, and genetic disorder (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster)
• The role of T cells in the anabolic activity of iPTH in trabecular bone (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of Molecular Pathways in Ischemia Reperfusion Injury after Liver Transplantation (, Mus musculus,Rattus norvegicus,Homo sapiens,Fasciola hepatica,NA)
• Never Say Die: Survival Signaling in Large Granular Lymphocyte Leukemia (, NA)
• Regulation of microRNA function in somatic stem cell proliferation and differentiation (, NA)
• Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information (, Escherichia coli,Yersinia pestis,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Human immunodeficiency virus)
• Endothelial cell metabolism in normal and diseased vasculature (, NA)
• Mammalian target of rapamycin (mTOR) signaling pathway (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention (, Homo sapiens,Escherichia coli,Staphylococcus aureus,Macaca mulatta,Porphyromonas gingivalis,Macaca fascicularis,Papio hamadryas,Escherichia coli KD2,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Cavia porcellus)
• Schematic illustration of the current concepts of mechanism by which adjudin perturbs apical ES function in the seminiferous epithelium to induce germ cell loss from the seminiferous epithelium (, NA)
• Complement in Monoclonal Antibody Therapy of Cancer (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida albicans,Homo sapiens)
• Convergence of DNA Damage Checkpoint Pathways and Androgen Receptor Signaling in Prostate Cancer (, NA)
• IL-10 signaling pathways in normal and abnormal conditions (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human betaherpesvirus 5,Homo sapiens,Diaporthe sclerotioides,Helicobacter pylori)
• Integrins in cancer: biological implications and therapeutic opportunities (, NA)
• Integration of the 3 major pathways that regulate skeletal muscle mass (, NA)
• Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Streptomyces peucetius subsp. caesius)
• Increased expression of DNA repair genes in invasive human pancreatic cancer cells (, Diaporthe sclerotioides,Olea europaea,Sequoia sempervirens,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Calloplesiops altivelis)
• A) Schematic outline of mitochondrial and metabolic pathways connected to the PPP in hepatocytes (, NA)
• Interplay between multiple factors in the transforming growth factorB (TGFB) signalling pathway and the control of muscle mass (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,adeno-associated virus 2)
• Molecular Pathways: Aspirin and Wnt Signaling—A Molecularly Targeted Approach to Cancer Prevention and Treatment (, NA)
• Major intracellular signal transduction pathways for CRF1 and CRF2 receptors (, NA)
• Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape (, NA)
• Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape (, NA)
• Interferon (IFN) signaling via the JAK–STAT pathway (, NA)
• Induction of interferon (IFN) and its antagonism by viral proteins (, NA)
• PI3K in cancer: divergent roles of isoforms, modes of activation, and therapeutic targeting (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus)
• Disease implications of the Hippo/YAP pathway (, NA)
• T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation (, Homo sapiens,Mus musculus,Candida dubliniensis)
• T Cell Energy Metabolism as a Controller of Cell Fate in Transplantation (, Homo sapiens,Mus musculus,Candida dubliniensis)
• Mammary gland epithelial cells form polarized acinar structures when cultured in 3D matrigel (, NA)
• Protein Processing and Inflammatory Signaling in Cystic Fibrosis: Challenges and Therapeutic Strategies (, Mus musculus,Rattus norvegicus,Homo sapiens,Pseudomonas aeruginosa)
• Probable sulfoquinovose biosynthesis pathway in S (, Sulfolobus acidocaldarius,Homo sapiens)
• Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment (, NA)
• Expression of the known genes involved in polo signaling in PAH HPASMC (, NA)
• 13C Isotope-Assisted Methods for Quantifying Glutamine Metabolism in Cancer Cells (, Homo sapiens,Bos taurus,unidentified)
• T Cell Metabolic Fitness in Anti-Tumor Immunity (, NA)
• TGFBeta-and bleomycin-induced extracellular matrix synthesis is mediated through Akt and mammalian target of rapamycin (mTOR) (, NA)
• Overcoming T cell exhaustion in infection and cancer (, NA)
• TLR/IL-1R, RLR, cGAS, and inflammasome signaling pathways (, NA)
• Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Dipturus trachyderma,Hippospongia communis,Gilia tricolor)
• Molecular pathway of glycolysis in NSPCs (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• TGFB signalling pathway and breast cancer susceptibility (, NA)
• Kinase targets and inhibitors (, Homo sapiens)
• Pathway Crosstalk (, NA)
• API5 confers tumoral immune escape through FGF2-dependent cell survival pathway (, Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Reported interactions between factors associated with Peters anomaly (, NA)
• Canonical and noncanonical NLR inflammasome activation (, Homo sapiens,Mus musculus)
• NOD signaling pathways (, Homo sapiens,Mus musculus)
• Emerging trends in the pathophysiology of lymphatic contractile function (, NA)
• Inhibition of the classical apoptosis and autophagy pathway by Gamma-herpesvirus proteins (, Human gammaherpesvirus 4,Human gammaherpesvirus 8,Murid gammaherpesvirus 4,Murid herpesvirus 68,Saimiriine gammaherpesvirus 2,Macacine gammaherpesvirus 5,Homo sapiens,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Macaca mulatta,Mus musculus,NA)
• Genome-wide dissection of microRNA functions and co-targeting networks using gene-set signatures (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Gallus gallus,Canis lupus familiaris)
• (De-) Oiling Inflammasomes (, NA)
• Gene network analysis for 18 key genes involved in age-dependent tumor progression (, Homo sapiens,Mus musculus,Armoracia rusticana)
• Diagram of EGFR signaling pathway showing impact of gefitinib and erlotinib on EGFR downstream signaling proteins (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Wnt signaling and regulation of Beta-catenin in tumorigenesis (, NA)
• Cartoon representing CsA-mediated activation of TGF B1-dependent signaling leading to epithelial-mesenchymal transition in epidermoid carcinoma cells (, NA)
• Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome (, NA)
• Initiation and perpetuation of NLRP3 inflammasome activation and assembly (, Measles morbillivirus,Encephalomyocarditis virus,Rift Valley fever virus,Saccharomyces cerevisiae,Mycobacterium tuberculosis,Candida albicans,Bacillus anthracis,Homo sapiens,Mus musculus,prion,NA)
• Cbl pathways (, NA)
• MicroRegulators come of age in senescence (, NA)
• Daam2-PIP5K Is a Regulatory Pathway for Wnt Signaling and Therapeutic Target for Remyelination in the CNS (, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,vectors,Avian retrovirus)
• Insulin/iGF-1 signaling pathway is conserved across phylogeny (, NA)
• Converging Pathways in Lifespan Regulation (, NA)
• Converging Pathways in Lifespan Regulation (, NA)
• S-nitrosylation in NFKB signaling (, Escherichia coli,Pseudomonas aeruginosa,Escherichia coli K-12,Mus musculus,Rattus norvegicus,Homo sapiens,Human T-cell leukemia virus type I,Antarctothoa delta)
• Natural history of Beta-cell adaptation and failure in type 2 diabetes (, NA)
• Proposed schema of aberrant signal transduction mediated by the TSLPR heterodimer in CRLF2-overexpressing ALL (, NA)
• Embryonic Stem Cell Self-Renewal (, Homo sapiens,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Embryonic Stem Cell Self-Renewal (, Homo sapiens,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Choosing the right path: does DNA-PK help make the decision? (, Mus musculus,Gallus gallus,Cricetus cricetus,Dipturus trachyderma,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Carma1/MALT1-dependent, Bcl10-independent, pathway regulates antigen receptor-mediated mTOR signaling in T cells (, NA)
• Dependence on signaling pathways based upon tumor suppressor status (, Mus musculus,Rattus norvegicus,Hepatitis B virus,Human gammaherpesvirus 4,Homo sapiens,Bartonella bacilliformis,NA)
• Pathway of all possible EGFR family dimer combinations showing various growth factors known to activate EGFR family and all possible dimer combinations (, Homo sapiens,Lareunionomyces loeiensis,Mycobacterium tuberculosis variant bovis BCG)
• Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation (, NA)
• JAK2 Inhibitors: What’s the true therapeutic potential? (, Diaporthe sclerotioides,Bikinia letestui,Homo sapiens,Mus musculus,Drosophila melanogaster)
• MTOR signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa)
• Basic intracellular molecular pathways regulating MN survival during development (, Mus musculus,Homo sapiens)
• ROS are important contributor to renal injury and inflammation (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Candida albicans)
• Activation of TGFB requires liberation of the TGFB dimer from an inactive latent complex with the LAP (, NA)
• An example of positive and negative regulation of the Ifn-signalling pathway (, Reovirus sp.,Murine hepatitis virus,Murine norovirus,dsRNA viruses,Homo sapiens,Mus musculus,Candida dubliniensis,NA)
• Adipocytokine signaling pathway as represented in the Kyoto Encyclopedia of Genes and Genomes (KEGG; http://www.genome.jp/kegg/kegg1.html) (; , ) (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Human immunodeficiency virus)
• Iron Homeostasis and the Inflammatory Response (, NA)
• Fanconi anemia pathway and ICL repair: implications for cancer therapy (, NA)
• Fanconi anemia pathway and ICL repair: implications for cancer therapy (, NA)
• Activated BMK1 MAPK cascade promotes cell cycle progression of tumor cells induced by mitogens and/or oncogenic signals (, NA)
• Therapies targeting the PI3K/AKT/mTOR pathway (, NA)
• Wnt signaling pathways (, Mouse mammary tumor virus,Bovine viral diarrhea virus 2,Homo sapiens,Mus musculus)
• Nutrients, Foods, and Colorectal Cancer Prevention (, Triticum aestivum,Brassica oleracea,Allium sativum,Homo sapiens,Mus musculus,Fusobacterium nucleatum)
• Diagram depicting altered mRNA expression of molecules involved in the regulation of the actin cytoskeleton by NMDA signaling pathways in schizophrenia (, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Diagram depicting molecules involved in actin cytoskeletal regulation mediated by NMDA signaling pathways and having altered mRNA expression in bipolar disorder (, Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Sex-specific regulation of mitochondrial maintenance pathways (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Accelerated Vascular Disease in Systemic Lupus Erythematosus: Role of Macrophage (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Nicotiana tabacum)
• INTERFERON-ALPHA MEDIATES THE DEVELOPMENT OF AUTOIMMUNITY BOTH BY DIRECT TISSUE TOXICITY AND THROUGH IMMUNE-CELL RECRUITMENT MECHANISMS (, NA)
• Treating brain tumors with PDE4 Inhibitors (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Phosphodiesterases and Cardiac cGMP: Evolving Roles and Controversies (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Diaporthe sclerotioides)
• Control of regulatory T cell lineage commitment and maintenance (, NA)
• Beta-Catenin immunohistochemistry in normal adult mouse liver (, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Canonical, Noncanonical, and Endoglin/ALK-1 signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• RHIM-dependent signaling (, NA)
• Glucosidase II and MRH-domain containing proteins in the secretory pathway (, Saccharomyces cerevisiae,Arabidopsis thaliana,Schizosaccharomyces pombe,Trypanosoma brucei,Leishmania major,Aspergillus oryzae,Dictyostelium discoideum,Leishmania mexicana,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Xenopus laevis,Vesicular stomatitis virus)
• Effect of Antibodies on Endothelium (, NA)
• Effect of Antibodies on Endothelium (, NA)
• Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus (, NA)
• Two-step scheme for metabolically engineering a cell surface with complementary chemical properties to bind to a custom-designed tissue engineering scaffold, as described in more detail in panels (b) and (c) (, Homo sapiens,Rattus norvegicus,Bos taurus)
• Histone deacetylase inhibitors and cell death (, NA)
• TIRs signaling pathway (, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Klebsiella pneumoniae,Streptococcus pyogenes,Haemophilus influenzae,Neisseria meningitidis,Mycobacterium avium,Streptococcus agalactiae,Citrobacter freundii,Salmonella enterica subsp. enterica serovar Enteritidis,Moraxella catarrhalis,Shigella sonnei,Mycobacterium avium subsp. avium,Streptococcus parasanguinis,Clostridium septicum,Klebsiella pneumoniae subsp. pneumoniae,Streptococcus milleri,Human gammaherpesvirus 4,Respiratory syncytial virus,Human gammaherpesvirus 8,Enterovirus C,Human alphaherpesvirus 3,Human betaherpesvirus 6,Human metapneumovirus,Human parvovirus B19,Rotavirus B,Lareunionomyces loeiensis,Candida albicans,Citrus deliciosa,Candida albicans 19F,Candida albicans 18M,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Meleagris gallopavo,NA)
• SnoN possesses both pro-oncogenic and anti-oncogenic activities (, NA)
• Albumin overload in tubular epithelial cells (, NA)
• We propose three possible pathways that could lead to liver NKT cell anergy (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Activation and Function of Small GTPases Rho, Rac, and Cdc42 During Gastrulation (, Saccharomyces cerevisiae,Danio rerio,Diaporthe sclerotioides,Xenopus laevis,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Human immunodeficiency virus)
• Simplified TAM signaling pathways in supporting cell proliferation and survival (A) and inhibiting inflammation (B) (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Arginine deiminase (ADI) hydrolyzes arginine into citrulline (, NA)
• Pharmacological targets in the nitric oxide (NO)-soluble guanylate cyclase (sGC) signaling pathway in pulmonary hypertension (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Nostoc sp. H)
• HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy (, NA)
• Signaling pathways deregulated in HPV-associated HNSCC (, NA)
• RPPA analysis in HeyA8-MDR treated with ZA (, NA)
• Fission Yeast-based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,Schizosaccharomyces pombe,Escherichia coli FBP1,Homo sapiens,Bos taurus,Drosophila melanogaster,vectors)
• Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway (, Bos taurus,Capra hircus,Homo sapiens,Mus musculus)
• Three levels of regulation of the IGF-IR pathwayand its components (, Homo sapiens,Mus musculus,Citrus macrophylla)
• Summary of the HGF/c-Met signaling pathway (, NA)
• Integrating chemical mutagenesis and whole genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia (, NA)
• IMD signaling pathway (, Escherichia coli,Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Enterococcus faecalis,Streptococcus pyogenes,Bordetella pertussis,Staphylococcus saprophyticus,Methylobacter luteus,Drosophila melanogaster,Tenebrio molitor,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Sus scrofa)
• Canonical TNFR to Nf-kB pathway (, Escherichia coli,Listeria monocytogenes,Burkholderia mallei,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Cellular and signaling pathway view of gene expression changes during alcohol withdrawal (, Mus musculus,Rattus norvegicus,Homo sapiens,Campodeidae sp. 1)
• The zif 268 pathway in spinal cord neurons (, NA)
• Novel functions of viral anti-apoptotic factors (, NA)
• Periodontal Innate Immune Mechanisms Relevant to Atherosclerosis (, Mycobacterium tuberculosis,Bacillus subtilis,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Treponema denticola,Prevotella intermedia,Homo sapiens,Mus musculus)
• Kreb's cycle used to determine relative flux rates through acetyl-CoA synthetase (ACS), pyruvate dehydrogenase complex (PDH), pyruvate carboxylase (PC), and glutamate dehydrogenase (GDH) (, Arabidopsis thaliana,Diaporthe sclerotioides,Matthiola incana,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Farnesoid X receptor (FXR) regulates enterohepatic circulation of bile acids (, Homo sapiens)
• Bile acid-activated S1P2 signaling (, Homo sapiens)
• Farnesoid X receptor (FXR) regulation of hepatic glucose and lipid metabolism in liver, adipocytes, and intestine (, Homo sapiens)
• Is Hepatitis C Virus Carcinogenic? (, Hepatitis B virus,Human gammaherpesvirus 8,Non-A non-B hepatitis virus,Homo sapiens,Pan troglodytes,Mus musculus,Danio rerio,NA)
• Kidney – Polycystic Kidney Disease (, NA)
• Obesity, insulin resistance and comorbidities – Mechanisms of association (, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Perfect Storm: HLA Antibodies, Complement, FcGRs and Endothelium in Transplant Rejection (, NA)
• Activation of mast cells initiates a cascade of events resulting in Th2 polarization and both positive and negative feedback regulatory loops (, Homo sapiens,Mus musculus,Bikinia letestui)
• Perfect Storm: HLA Antibodies, Complement, FcGRs and Endothelium in Transplant Rejection (, NA)
• Innate Immune Evasion by Filoviruses (, NA)
• RIG-I signaling pathway (, NA)
• Receptor-mediated activation of PI3K-Akt pathway and signaling (, NA)
• Original and reduced EGFR models (, NA)
• Transcriptional regulation of cranial sensory placode development (, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Tetrapoda,Homo sapiens,Mus musculus,Drosophila melanogaster,Bovine adenovirus 3)
• The fundamental aspects of the DNA damage response pathway (, Mus musculus,Rattus norvegicus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens)
• Signaling Mechanisms for Chemotaxis (, NA)
• Proteomic Profiling of a Biomimetic Drug Delivery Platform (, NA)
• Schematic summary graph shows that mGluR2/3 agonists reduce glutamate release at presynaptic site by inhibiting AC-cAMP-PKA signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Dryobalanops aromatica)
• Schematic summary graph shows the postsynaptic effects of mGluR2/3 agonists on the regulation of both AMPA and NMDA receptors (, Mus musculus,Rattus norvegicus,Homo sapiens,Dryobalanops aromatica)
• Pathogenesis of Aortopathy in Marfan Syndrome and Related Diseases (, Drosophila melanogaster,Caenorhabditis elegans,Antarctothoa delta,Homo sapiens,Mus musculus)
• Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Sequoia sempervirens,Phytolacca americana,Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Capra hircus,Homo sapiens,Escherichia coli,Human immunodeficiency virus 1,Calloplesiops altivelis)
• Global gene expression and Ingenuity biological functions analysis on PCB 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Sequoia sempervirens,Phytolacca americana,Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Capra hircus,Homo sapiens,Escherichia coli,Human immunodeficiency virus 1,Calloplesiops altivelis)
• Phospholipase A2-derived Mediators in Obesity (, NA)
• CoQ10 biosynthesis pathway (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Summary of the CF signal transduction pathway (, NA)
• PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans (, Caenorhabditis elegans,Homo sapiens)
• Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term (, NA)
• Evolutionary Changes in Promoter and Enhancer Activity During Human Corticogenesis (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Can we safely target the WNT pathway? (, NA)
• Mitochondria-targeted neuroprotective interventions for acute injury to the immature brain (, NA)
• Eph receptor and mTOR pathway crosstalk: implications for cancer (, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Growth signaling pathway affected by arginine deprivation in ASS(−) cells which leads to autophagy (, NA)
• The identified epigenetic regulatory mechanism involved in the miR-124/STAT3 pathway in pediatric-UC (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Helicobacter pylori)
• Schematic drawing to illustrate the neurochemistry and molecular mechanisms of c-fos and Fos expression in strongly activated neurons in prefrontal cortex and nucleus accumbens of awake behaving animals (, NA)
• Pathway map of the histamine receptor response in dendritic cell (, NA)
• Pathway map of the Prtostaglandin E2 receptor signaling (, NA)
• Ratio heatmaps of identified canonical TCR signaling proteins that showed significant changes of phosphopeptide abundance for both types of stimulation (q value < 0.05; > 2–fold or < 0.5-fold) (, NA)
• Biochemical pathways leading to the synthesis of TAG and cholesterol (, Hepatitis B virus,Mouse mammary tumor virus,Japanese encephalitis virus,Dengue virus group,Hepatitis C virus JFH-1,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• Functional pathway analysis of the 28-gene prognostic signature using Ingenuity Pathway Analysis (, Homo sapiens,Sequoia sempervirens,Alburnus alburnus)
• Hypothalamic proopiomelanocortin processing and the regulation of energy balance (, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus,Darksidea alpha)
• Toll-like receptor Signaling in Neural Plasticity and Disease (, NA)
• Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway (, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Mediators released from activated MCs (, NA)
• Distal Axonal Degeneration in Peripheral Neuropathies (, Campylobacter jejuni,Human immunodeficiency virus 2)
• Regulation of miRNA biogenesis as an integrated component of growth factor signaling (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio,Human immunodeficiency virus 1)
• Neurodegenerative diseases are among the most common diseases and yet probing the pathological mechanisms has remained a challenge (, NA)
• Smad-mediatedregulation of microRNA biosynthesis (, NA)
• Schema of the PI3K pathway (, NA)
• Parameter estimates from the best-fitting common pathway model for cannabis, stimulant and sedative abuse in Swedish male–male twin and near-aged sibling pairs (, Homo sapiens,Cannabis sativa)
• HER2-mediated PI3K-Akt signaling pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Armoracia rusticana,Medicago sativa,Homo sapiens,Mus musculus,Escherichia coli)
• Dendritic cell control of tolerogenic responses (, NA)
• Transcription factor restricted functional interactions with ERA in osteoblasts (, NA)
• Hypothetical involvement of glucokinase (GK) and therefore glucokinase activators (GKAs) in the preservation and growth promotion of pancreatic Beta-cells (, NA)
• Physiological consequences of membrane-initiated estrogen signaling in the brain (, NA)
• ROLE OF NRF2 IN THE OXIDATIVE STRESS-DEPENDENT HYPERTENSION ASSOCIATED WITH THE DEPLETION OF DJ-1 (, NA)
• Examples of cellular receptors that sense infection and cell death (, NA)
• Ligand-dependent LRP6 endocytosis (, Drosophila melanogaster,Caenorhabditis elegans,Fasciola hepatica,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Lareunionomyces loeiensis)
• Surface Fzd density by R-spondin-LGR5-RNF43 (, Drosophila melanogaster,Caenorhabditis elegans,Fasciola hepatica,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Lareunionomyces loeiensis)
• Investigational cancer drugs targeting cell metabolism in clinical development (, Escherichia coli,Dickeya chrysanthemi,Homo sapiens,Silybum marianum)
• Viperin Links Lipid Bodies To Immune Defense (, Homo sapiens,Mus musculus,NA)
• Update on the regulation of mammalian melanocyte function and skin pigmentation (, NA)
• Notch signaling as a novel regulator of metabolism (, Homo sapiens,Mus musculus)
• Long-term synaptic plasticity at inhibitory synapses (, NA)
• Notch signaling as a novel regulator of metabolism (, Homo sapiens,Mus musculus)
• MOLECULAR CROSSTALK BETWEEN p70S6K AND MAPK CELL SIGNALING PATHWAYS (, NA)
• Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma (, NA)
• Adipocyte receptors that have been proposed to promote the browning of white fat or maintenance of a brown adipocyte (BA) phenotype (, NA)
• Illustration of the deformation-induced ATP release pathway, highlighting the importance of glucose metabolism via the pentose phosphate pathway (, NA)
• Genetic Variants in the Fibroblast Growth Factor Pathway as Potential Markers of Ovarian Cancer Risk, Therapeutic Response, and Clinical Outcome (, NA)
• HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Downstream components of ERK in SCN neurons (, NA)
• P38 MAPK in the circadian clock (, NA)
• JNK MAPK in the circadian clock (, NA)
• Transcriptional regulation of the OS MAPK pathway by the circadian clock in Neurospora (, NA)
• Proteins from known pathways localized to the Trichomonas vaginalis hydrogensome (, Trichomonas vaginalis,Homo sapiens)
• Wnt signaling pathways (, NA)
• Tempering Allorecognition to Induce Transplant Tolerance With Chemically Modified Apoptotic Donor Cells (, Mus musculus,Cavia porcellus,Homo sapiens,Human immunodeficiency virus 1)
• The Beta-cell exocytosis regulatory system (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Context-dependent control of alternative splicing by RNA-binding proteins (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,prion)
• UVB Radiation-Induced Beta-catenin Signaling is Enhanced by COX-2 Expression in Keratinocytes (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Dipturus trachyderma)
• Mevalonate pathway (, NA)
• Repulsive Guidance Molecules (RGMs) and Neogenin in Bone Morphogenetic Protein (BMP) signaling (, NA)
• Obesity, immunomodulation and chronic kidney disease (, Mus musculus,Rattus norvegicus,Homo sapiens)
• M1 and M2 Immune Activation in Parkinson’s Disease: Foe and Ally? (, Mus musculus,Rattus norvegicus,Human betaherpesvirus 5,adeno-associated virus 2,Homo sapiens,Gallus gallus,Staphylococcus aureus,Candida dubliniensis)
• Activation of the JAK/STAT pathway in Behcet’s Disease (, NA)
• Model diagram of tumor necrosis factor-alpha (TNFA) signaling (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Suppression of Antigen Presentation by IL-10 (, Mycobacterium tuberculosis,Francisella tularensis,Homo sapiens,Mus musculus,Human betaherpesvirus 5)
• Catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway (, NA)
• Bcl-2 as an attractive target for modulating different modes of cell death in cancer therapy due to close communications with mediators of apoptosis, programmed necrosis, and autophagy (, NA)
• Development and in vivo function of TH9 cells (, NA)
• Model depicting PPP1R12A/PP1cD in the insulin signaling pathway (, NA)
• Slit/Robo interactions and their roles in carcinogenesis (, NA)
• Top enriched network associated with BCa progression (, Homo sapiens,clinical samples,Regulus ignicapilla)
• Key components of the Wnt/Beta-catenin signaling pathway (, NA)
• AMPK is a negative regulator of the Warburg effect in Fumarate hydratase-deficient kidney cancer (, NA)
• Resistance to BCR-ABL1 tyrosine kinase inhibitors may take the form of (left) point or compound mutation-based, BCR-ABL1-dependent resistance or (middle) recruitment of alternative pathway signaling upon effective inhibition of BCR-ABL1 (, Homo sapiens,Mus musculus,Bellapiscis medius,NA)
• Of flies, mice and men: Evolutionarily conserved tissue damage responses and aging (, NA)
• Prostaglandin pathways in duodenal chemosensing (, Mus musculus,Rattus norvegicus,Cavia porcellus,Saccharomyces cerevisiae,Helicobacter pylori,Candida albicans,Campylobacter jejuni,Homo sapiens,Drosophila melanogaster)
• Impacts of environmental toxicants on male reproductive dysfunction (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Sus scrofa)
• BAFF and APRIL signaling pathways in B cells (, NA)
• Differential requirement of STAT for RTK signaling (, Homo sapiens,Drosophila melanogaster)
• Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer (, NA)
• Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy (, NA)
• Rationale for simultaneous targeting of SK and Raf for cancer chemotherapy (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Pericytes, microvasular dysfunction and chronic rejection (, NA)
• Pericytes, microvasular dysfunction and chronic rejection (, NA)
• The regulation for CD300B expression (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Mus musculus,Escherichia coli)
• Regulatory role of ATM in cellular responses to DNA DSB repair (, NA)
• Mechanisms by which Beta-cell failure an apoptosis occur are complex, not completely unraveled and involve the interplay of numerous factors and conditions (, NA)
• Basal cell carcinomas: attack of the hedgehog (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Zea mays,Ovis aries,Paraechinus aethiopicus,Antarctothoa delta,Veratrum californicum,Homo sapiens,Gallus gallus,NA)
• The extracellular network of proteins that control D–V patterning (, Canis lupus familiaris,Eutheria,Ornithorhynchus anatinus,Monodelphis domestica,Gallus gallus,Danio rerio,Xenopus laevis,Drosophila melanogaster,Branchiostoma lanceolatum,Homo sapiens,Mus musculus)
• Therapeutic effects can be monitored using DMR on scant cell populations (, NA)
• Reelin-Disabled-1 signaling in neuronal migration: Splicing takes the stage (, NA)
• Protein Cys map to functional pathways based upon percent oxidation (, NA)
• Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases (, NA)
• Apoptosis: intrinsic, extrinsic, and endoplasmic reticulum (ER) stress mechanisms (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic model for the role of TGFB signaling pathways in iTreg and Th17 cell development (, NA)
• Unexpected Functions of NFKB during Germinal Center B-Cell Development: Implications for Lymphomagenesis (, Homo sapiens,Mus musculus,Canis lupus familiaris,Human gammaherpesvirus 8)
• Cellular and bacterial profiles associated with oral epithelium-microbiota interactions (, Helicobacter pylori,Porphyromonas gingivalis,Lactococcus lactis,Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans,Streptococcus gordonii,Lactococcus lactis subsp. lactis,Saccharomyces cerevisiae,Candida albicans,Olea europaea,Homo sapiens,Mus musculus,Plasmodium berghei ANKA)
• Kruppel-like factor 5 is required for perinatal lung morphogenesis and function (, NA)
• Fatty acid remodeling of membrane phospholipid (compartment A) (, Homo sapiens,Mus musculus)
• Diacylglycerol kinase (DGK) signaling in vascular smooth muscle contraction (, Mus musculus,Rattus norvegicus,Homo sapiens,Bipolaris sacchari)
• Pathway of Net Citrate Production in Prostate Epithelial Cells (, NA)
• Ste5 coordinates signal activation in the yeast mating pathway (, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae)
• NH2-terminal Propeptide of Type I Procollagen Acts Intracellularly to Modulate Cell Function (, NA)
• Representation of genes of the vascular endothelial growth factor (VEGF) signaling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib, and cilengitide are known to act (, Homo sapiens,Mus musculus)
• Prevalent mutations in acute myeloid leukemia (AML) potentially affect HIF levels in cancer cells (, NA)
• Intracellular signaling by the leptin (LepRb - cyan) and insulin receptor (magenta) (, NA)
• ALDOSE REDUCTASE: New Insights for an Old Enzyme (, NA)
• Inherited dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis (, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Mustela putorius furo,Homo sapiens,Ziziphus mauritiana)
• Pituitary adenylate cyclase activating polypeptide in stress-related disorders: data convergence from animal and human studies (, NA)
• a, Gene interaction map of Reactome pathway analysis that discovers alteration of FGFR signaling as the most altered pathway (, Homo sapiens,Mus musculus,Bos taurus)
• Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulva network (, NA)
• Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6 (, NA)
• Mechanistic diagram showing how Notch could promote EMT progress (, NA)
• Crosstalk between Wnt, PTH and BMP signalling in cartilage and bone cell lineages (, NA)
• Investigational approaches targeting the factors contributing to celiac disease pathogenesis (, NA)
• Adrenergic receptor signaling and cross-talk with the renin-angiotensin aldosterone system (, Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Rattus norvegicus,Adeno-associated virus)
• Proposed mechanism by which hyperaldosteronism decreases pulmonary endothelial eNOS activation and nitric oxide (NO•) generation in PAH (, Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Rattus norvegicus,Adeno-associated virus)
• Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer (, NA)
• Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer (, NA)
• Genome-wide association study points to multiple loci predicting antidepressant treatment outcome in depression (, NA)
• Brain insulin resistance in Alzheimer’s disease and its potential treatment with GLP-1 analogs (, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa,Dipnomorpha)
• Advances in recent patent and clinical trial drug development for Alzheimer’s disease (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Platycladus orientalis)
• Tracking surface glycans on live cancer cells with single molecule sensitivity (, NA)
• Pathway of net citrate production in citrate-producing prostate epithelial cells (, Homo sapiens)
• Summary of altered glucose metabolism in MCF10A-ras cells (, Homo sapiens,Mus musculus,Equus caballus,Moloney murine leukemia virus)
• Mechanisms on CYP2J2/EETs mediated macrophage polarization in response to LPS-induced inflammation and cardiac dysfunction (, Mus musculus,Rattus norvegicus,Adeno-associated virus,adeno-associated virus 2,Homo sapiens,Bos taurus,Escherichia coli,Armoracia rusticana)
• Intracellular levels of BH4 depend on three production conduits the de novo synthesis pathway, the recycling pathway and the salvage pathway (, NA)
• Drosophila IMD pathway (, Drosophila melanogaster,Homo sapiens)
• Gut microbiota in the development of T1D (, Clostridioides difficile,Lactococcus lactis,Bacteroides fragilis,Akkermansia muciniphila,Clostridioides difficile CD3,Candidatus Arthromitus sp. SFB-mouse,Bifidobacterium adolescentis,Lactobacillus johnsonii,Lactobacillus johnsonii N6.2,gut metagenome,human gut metagenome,human metagenome,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Innate Immune Evasion In Re-Emerging RNA Viruses (, NA)
• Schematic of viral RNA recognition and antiviral signal activation by RIG-I and MDA5 (, NA)
• Anti-apoptotic mechanisms of Akt (, NA)
• Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling (, NA)
• Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis (, NA)
• Cyclic AMP-Mediated Cyst Expansion (, NA)
• Commitment and maintenance of gonadal cell fate (, NA)
• Synapse dysfunction: as a consequence of MAPK and mitochondrial oxidative stress-mediated tau hyperphosphorylation (, NA)
• Endocannabinoid signalling and the deteriorating brain (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Cannabis sativa)
• Pathway of net citrate production in citrate-producing prostate epithelial cells (, Homo sapiens)
• E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses (, NA)
• E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses (, NA)
• E3 Ubiquitin Ligases Pellinos as Regulators of Pattern Recognition Receptor Signaling and Immune responses (, NA)
• Representative cascade of the TGFB pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Haemophilus influenzae)
• Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples)
• HMGB factors are required for posterior digit development through integrating signaling pathway activities (, Oryctolagus cuniculus,Gallus gallus,Danio rerio,Capra hircus,Homo sapiens,Mus musculus)
• Targeting signaling factors for degradation, an emerging mechanism for TRAF functions (, Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Respiratory syncytial virus,Vesicular stomatitis virus,Ateline gammaherpesvirus 2,Listeria monocytogenes,Streptococcus sp. group B,Homo sapiens,Mus musculus,Canis lupus familiaris,NA)
• Dysregulation of astrocyte extracellular signaling in Costello syndrome (, NA)
• Biosynthetic pathway of prostanoids (, NA)
• Regulation of Lymphocyte Function by Adenosine (, NA)
• PARPs and ADP-Ribosylation: Fifty Years… and Counting (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Bos taurus,Escherichia coli,Drosophila melanogaster)
• Schematic diagram of Notch, InR/Akt, and JNK signaling pathways (, NA)
• Sry-type HMG box 18 Contributes to the differentiation of Bone Marrow-derived Mesenchymal Stem Cells to Endothelial Cells (, NA)
• Cross-species comparison of PCD factors implicated in aging (, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,NA)
• MTOR-mediated T cell activation and lineage specification (, NA)
• A RhoB-dependent endosomal trafficking pathway that couples RTK stimulation to Cdc42/Rac activation, localized actin dynamics, and cell migration (, Bos taurus,Canis lupus familiaris,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Parenteral Nutrition Impairs Lymphotoxin B Receptor Signaling via NF- KB (, Mus musculus,Cricetus cricetus,Homo sapiens)
• Pharmacologically targetable regulatory checkpoints of the mTOR pathway (, NA)
• Immune Responses to HCV and Other Hepatitis Viruses (, Hepatitis B virus,Simian immunodeficiency virus,Hepatovirus A,Hepatitis delta virus,Stealth virus 1,Homo sapiens,Pan troglodytes,Mus musculus,NA,NA,NA)
• Simplified schematics of the MAPK and PI3K pathways in melanoma and the clinical compounds available for their inhibition (, Homo sapiens,Mus musculus)
• SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (, NA)
• SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (, NA)
• SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (, NA)
• CXCL12 (SDF1A) – CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anti-Cancer Therapies? (, NA)
• CAMP-PKA-CREB pathway, a signaling cascade that is critical for memory formation, induces expression of the genes encoding NR4A nuclear receptors (, NA)
• Signaling by myeloid C-type lectin receptors in immunity and homeostasis (, NA)
• Signaling by myeloid C-type lectin receptors in immunity and homeostasis (, NA)
• Sensing of cell death by myeloid C-type lectin receptors (, NA)
• Cell signalling pathways for the regulation of GATA4 transcription factor: Implications for cell growth and apoptosis (, NA)
• Heme Oxygenase-1, a Critical Arbitrator of Cell Death Pathways in Lung Injury and Disease (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Nicotiana tabacum,Candida dubliniensis,Homo sapiens,Escherichia coli,Oryctolagus cuniculus)
• Signaling Cell Death from the Endoplasmic Reticulum Stress Response (, Homo sapiens,Mus musculus,Candida dubliniensis,Coxsackievirus B3,NA)
• From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry (, NA)
• B1-adrenergic receptors activate multiple pathways in striatal neurons (, NA)
• Gene expression changes in response to zebularine therapy in vivo (, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Bikinia letestui,Homo sapiens,Canis lupus familiaris)
• Widespread extracellular matrix (ECM) pathway silencing by DNA hypermethylation in colon cancer (, Homo sapiens,Bos taurus,Gallus gallus,unidentified,Citrus macrophylla)
• Structures of schweinfurthin B and 3-deoxyschweinfurthin B (3dSB) (, NA)
• BCR Signaling Pathway and Small Molecule Inhibitors of BCR Signaling (, Corynephage beta,Corynebacterium phage gamma,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Human gammaherpesvirus 8)
• Glycogen Synthase Kinase-3 in Insulin and Wnt Signalling : a Double-edged Sword? (, Homo sapiens)
• Glycogen Synthase Kinase-3 in Insulin and Wnt Signalling : a Double-edged Sword? (, Homo sapiens)
• New Model of Reverse Cholesterol Transport: EnTICEing Strategies to Stimulate Intestinal Cholesterol Excretion (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Drosophila melanogaster,NA)
• Autophagy in Autoimmune Disease (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Komagataella pastoris,Homo sapiens)
• Activation of glia and neurons in the dorsal horn of the spinal cord after peripheral injury (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Akt regulates numerous biological functions by phosphorylating distinct protein substrates (, NA)
• Neural Tube Defects (, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Drosophila melanogaster)
• Fueling Immunity: Insights into Metabolism and Lymphocyte Function (, NA)
• Fueling Immunity: Insights into Metabolism and Lymphocyte Function (, NA)
• Downstream signaling pathways of the ANG1-7/Mas pathway in non-epithelial lung cell types (, NA)
• Microbial manipulation of receptor crosstalk in innate immunity (, Mycobacterium tuberculosis,Enterococcus faecalis,Porphyromonas gingivalis,Bacillus anthracis,Bordetella pertussis,Escherichia coli,Staphylococcus aureus,Helicobacter pylori,Listeria monocytogenes,Streptococcus pyogenes,Borreliella burgdorferi,Clostridium perfringens,Neisseria meningitidis,Francisella tularensis,Neisseria gonorrhoeae,Streptococcus sp. group A,Mycobacterium leprae,Streptococcus sp. group B,Coxiella burnetii,bacterium B,Mycobacterium kansasii,Human immunodeficiency virus 1,Human betaherpesvirus 5,Measles morbillivirus,Human betaherpesvirus 6,Myxoma virus,Orf virus,Equid gammaherpesvirus 2,Plasmodium falciparum,Leishmania major,Schistosoma mansoni,Cerobasis alpha,Ixodes scapularis,Candida dubliniensis,Candida albicans,Histoplasma capsulatum,Homo sapiens,Mus musculus,NA)
• Microbial manipulation of receptor crosstalk in innate immunity (, Porphyromonas gingivalis,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Listeria monocytogenes,Enterococcus faecalis,Streptococcus pyogenes,Bacillus anthracis,Borreliella burgdorferi,Clostridium perfringens,Neisseria meningitidis,Francisella tularensis,Neisseria gonorrhoeae,Streptococcus sp. group A,Mycobacterium leprae,Streptococcus sp. group B,Coxiella burnetii,Bordetella pertussis,bacterium B,Mycobacterium kansasii,Human immunodeficiency virus 1,Human betaherpesvirus 5,Measles morbillivirus,Human betaherpesvirus 6,Myxoma virus,Orf virus,Equid gammaherpesvirus 2,Plasmodium falciparum,Leishmania major,Schistosoma mansoni,Cerobasis alpha,Ixodes scapularis,Candida dubliniensis,Candida albicans,Histoplasma capsulatum,Homo sapiens,Mus musculus,NA)
• Microbial manipulation of receptor crosstalk in innate immunity (, Helicobacter pylori,Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Enterococcus faecalis,Porphyromonas gingivalis,Streptococcus pyogenes,Bacillus anthracis,Borreliella burgdorferi,Clostridium perfringens,Neisseria meningitidis,Francisella tularensis,Neisseria gonorrhoeae,Streptococcus sp. group A,Mycobacterium leprae,Streptococcus sp. group B,Coxiella burnetii,Bordetella pertussis,bacterium B,Mycobacterium kansasii,Human immunodeficiency virus 1,Human betaherpesvirus 5,Measles morbillivirus,Human betaherpesvirus 6,Myxoma virus,Orf virus,Equid gammaherpesvirus 2,Plasmodium falciparum,Leishmania major,Schistosoma mansoni,Cerobasis alpha,Ixodes scapularis,Candida dubliniensis,Candida albicans,Histoplasma capsulatum,Homo sapiens,Mus musculus,NA)
• Microbial manipulation of receptor crosstalk in innate immunity (, Escherichia coli,Staphylococcus aureus,Neisseria meningitidis,Mycobacterium tuberculosis,Helicobacter pylori,Listeria monocytogenes,Enterococcus faecalis,Porphyromonas gingivalis,Streptococcus pyogenes,Bacillus anthracis,Borreliella burgdorferi,Clostridium perfringens,Francisella tularensis,Neisseria gonorrhoeae,Streptococcus sp. group A,Mycobacterium leprae,Streptococcus sp. group B,Coxiella burnetii,Bordetella pertussis,bacterium B,Mycobacterium kansasii,Human immunodeficiency virus 1,Human betaherpesvirus 5,Measles morbillivirus,Human betaherpesvirus 6,Myxoma virus,Orf virus,Equid gammaherpesvirus 2,Plasmodium falciparum,Leishmania major,Schistosoma mansoni,Cerobasis alpha,Ixodes scapularis,Candida dubliniensis,Candida albicans,Histoplasma capsulatum,Homo sapiens,Mus musculus,NA)
• Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Cricetus cricetus,Agaricus bisporus,Berberis aristata,Homo sapiens,Adeno-associated virus)
• Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Cricetus cricetus,Agaricus bisporus,Berberis aristata,Homo sapiens,Adeno-associated virus)
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (, NA)
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (, NA)
• Speculative model of FGF23 gene transcriptional regulation (, NA)
• miRNAs as biological and clinical determinants in colorectal cancer (, Homo sapiens,Mus musculus,Microbacterium aurantiacum)
• When pathways collide: collaboration and connivance among signaling proteins in development (, NA)
• When pathways collide: collaboration and connivance among signaling proteins in development (, NA)
• Effect of sphingolipids on the PI3K/AKT pathway (, NA)
• Sphingolipid effects on intrinsic and extrinsic apoptotic pathways (, NA)
• Oxidative pathways leading to neuronal cell death and glial cell inflammation: protective effects of resveratrol (, NA)
• Working model of molecular mechanism(s) by which chronic Pb2+ exposure disrupts synapse formation and plasticity in developing hippocampal neurons (, NA)
• When pathways collide: collaboration and connivance among signaling proteins in development (, NA)
• Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction (, NA)
• Tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization (, NA)
• Model depicting interactions of putative nutrient and energy signaling components (, Saccharomyces cerevisiae,Arabidopsis thaliana,Nicotiana tabacum,Oryza sativa,Solanum lycopersicum,Embryophyta,Solanum tuberosum,Triticum aestivum,Spinacia oleracea,Pisum sativum,Homo sapiens)
• When pathways collide: collaboration and connivance among signaling proteins in development (, NA)
• Vav1 regulates T cell activation through a feedback mechanism and crosstalk between the T cell receptor and CD28 (, Bos taurus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Corynebacterium phage gamma,Human rhinovirus sp.)
• Possible pathways of Cd-induced MAPK/ERK signaling (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Pseudomonas aeruginosa)
• IRE1–RIDD–RIG-I pathway (, Escherichia coli,Vibrio cholerae,Vibrio cholerae O1,Saccharomyces cerevisiae,Schizosaccharomyces pombe,unidentified influenza virus,Human betaherpesvirus 5,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Interaction of the TFF2-CXCR4 axis with the active RAS-RAF-MEK-ERK pathway in the serrated pathway of colorectal cancer (, NA)
• Effect of the combination of rapamycin and resveratrol on the PI3K/Akt/mTORC1 signaling pathway (, NA)
• Proposed Model For the Convergence of Signaling Between mTOR and PPARG Agonists in Endothelial Cells (, NA)
• First Tianjin, China Forum on Tumor Microenvironment (, NA)
• Targeting of Adenosine Receptors in Ischemia-Reperfusion Injury (, NA)
• Targeting GSK-3 family members in the heart: A very sharp double-edged sword (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Corynephage beta)
• Local control of Beta-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca2+-transient (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris)
• Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition (, Homo sapiens,Mus musculus)
• New Biology of Estrogen-induced Apoptosis Applied to Treat and Prevent Breast Cancer (, Homo sapiens)
• Parsing out the complexity of RAF inhibitor resistance (, Homo sapiens,NA)
• ROS have different origins (, Xenopus laevis,Dipturus trachyderma,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Dendritic cell metabolism (, Mus musculus,Cricetulus griseus,Homo sapiens,Listeria monocytogenes,Vesicular stomatitis virus,Ambrosia artemisiifolia)
• Proposed LNM (1) biosynthetic pathway featuring LnmKLM-catalyzed Beta-alkylation of the LnmJ PKS module-8 ACP-tethered intermediate in the S (, NA)
• Dendritic cell metabolism (, Mus musculus,Cricetulus griseus,Homo sapiens,Listeria monocytogenes,Vesicular stomatitis virus,Ambrosia artemisiifolia)
• Migration of FGF7-stimulated epithelial cells and VEGF-A-stimulated HUVECs depends on EGFR transactivation by ADAM17 (, NA)
• B cell- and BAFF-dependence of IFNAlpha-exaggerated disease in SLE-prone NZM 2328 mice (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Diaporthe sclerotioides,Adenoviridae)
• Dendritic cell metabolism (, Mus musculus,Cricetulus griseus,Homo sapiens,Listeria monocytogenes,Vesicular stomatitis virus,Ambrosia artemisiifolia)
• Dendritic spine dysgenesis in Autism Related Disorders (, NA)
• The signaling pathway involved in EPO-induced neuroprotection (, Mus musculus,Rattus norvegicus,Meriones unguiculatus,Homo sapiens,Oryctolagus cuniculus)
• IL-6 Receptor and gp130 Receptor signaling: IL-6 binds to the IL-6 receptor (1) (, Homo sapiens,Mus musculus,Corynocarpus laevigatus)
• Childhood Obesity – 2010: Progress and Challenges (, Gekko adenovirus,Human adenovirus 36,Homo sapiens,Mus musculus,gut metagenome,Equus caballus)
• TGFB signaling pathway TGFB is secreted in a latent form and activation is mediated by several molecules including furin and emilin (, Homo sapiens,Mus musculus,Drosophila melanogaster,Diaporthe sclerotioides)
• Sedative Drug Modulates T-Cell and Lymphocyte Function-Associated Antigen-1 Function (, NA)
• Complement and Viral Pathogenesis (, NA)
• Friendly, and not so friendly, roles of Rac1 in islet Beta-cell function: Lessons learnt from pharmacological and molecular biological approaches (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Cone-specific Visual Cycle (, Gallus gallus,Danio rerio,Cyprinus carpio,Lithobates catesbeianus,Lithobates pipiens,Dipturus batis,Ambystoma tigrinum,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sciurus carolinensis,Homo sapiens)
• Functions of 14-3-3 in tumor-suppressor pathways (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Linking actin dynamics and gene transcription to drive cellular motile functions (, NA)
• Linking actin dynamics and gene transcription to drive cellular motile functions (, NA)
• MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics (, NA)
• An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Heme biosynthetic pathway (, NA)
• Metabolism and transport of acetaminophen in the liver at highly toxic doses (, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome,Avena sativa)
• Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer’s disease (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,prion)
• WNT/Beta-catenin signaling pathway (, Homo sapiens,Mus musculus,Gallus gallus,Diaporthe sclerotioides)
• Mammalian inositol phosphate metabolism (, NA)
• Oxidative stress induces aberrant signaling pathways (, NA)
• Carbon flux rerouting during Mycobacterium tuberculosis growth arrest (, Mycobacterium tuberculosis,Homo sapiens)
• Inhibition of NFKB signaling retards eosinophilic dermatitis in SHARPIN-deficient mice (, NA)
• Activity change and interaction of key molecular targets downstream of oxidative stress induced by maternal diabetes (, NA)
• What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity (, Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Human alphaherpesvirus 1,Human papillomavirus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,DNA viruses,Betapolyomavirus macacae,Human adenovirus 5,Polyomavirus sp.,Merkel cell polyomavirus,Escherichia coli,Helicobacter pylori,Plasmodium falciparum,Toxoplasma gondii,Campylobacter jejuni,Chlamydia trachomatis,Aggregatibacter actinomycetemcomitans,Cryptosporidium parvum,Helicobacter hepaticus,Trichomonas vaginalis,Alveolata,Haemophilus ducreyi,Theileria parva,Theileria annulata,Homo sapiens,Mus musculus,Bos taurus,gut metagenome,NA,NA)
• What’s the Damage? The Impact of Pathogens on Pathways that Maintain Host Genome Integrity (, Hepatitis B virus,Human gammaherpesvirus 4,Adenoviridae,Human alphaherpesvirus 1,Human papillomavirus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,DNA viruses,Betapolyomavirus macacae,Human adenovirus 5,Polyomavirus sp.,Merkel cell polyomavirus,Escherichia coli,Helicobacter pylori,Plasmodium falciparum,Toxoplasma gondii,Campylobacter jejuni,Chlamydia trachomatis,Aggregatibacter actinomycetemcomitans,Cryptosporidium parvum,Helicobacter hepaticus,Trichomonas vaginalis,Alveolata,Haemophilus ducreyi,Theileria parva,Theileria annulata,Homo sapiens,Mus musculus,Bos taurus,gut metagenome,NA,NA)
• TRAIL signaling pathway (, NA)
• Proof of Concept Trials in Bipolar Disorder and Major Depressive Disorder: A Translational Perspective in the Search for Improved Treatments (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Salvia divinorum)
• TRAIL signaling pathway and some points of therapeutic intervention (, NA)
• Downward traffic of the FSHR is linked to intracellular signaling pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,unidentified influenza virus)
• Cytokines determined to be up-regulated in plasma collected from pancreatic adenocarcinoma patients (, Homo sapiens,Mus musculus,Sequoia sempervirens)
• MDM2-p53 Pathway in Hepatocellular Carcinoma (, NA)
• Cohesin regulates expression of genes that control differentiation, morphogenesis, proliferation, and pluripotency (, Saccharomyces cerevisiae,Agaricus bisporus,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Human gammaherpesvirus 8)
• Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation (, Homo sapiens,Mus musculus,Gallus gallus,Canis lupus familiaris)
• Top-scoring network created by Ingenuity Pathway Analysis (, Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• Lessons on transcriptional control from the serum response network (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Avian erythroblastosis virus E26)
• TUMOR NECROSIS FACTORA INCREASES BDNF EXPRESSION IN TRIGEMINAL GANGLION NEURONS IN AN ACTIVITY-DEPENDENT MANNER (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Representative axon regeneration-regulating pathways discovered in genetic model organisms (, NA)
• Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Raphanus sativus,Phellodendron amurense,Homo sapiens)
• Distribution of three proposed variants of UxaE-involving pathways for hexuronate utilization in Bacteria.A (, Thermotoga maritima)
• iNKT cell autoreactivity: what is “self” and how is it recognized? (, Helicobacter pylori,Listeria monocytogenes,Salmonella enterica,Borreliella burgdorferi,Sphingomonas paucimobilis,Homo sapiens,Mus musculus,Murid betaherpesvirus 1)
• Linear ubiquitination signals in adaptive immune responses (, NA)
• Linear ubiquitination signals in adaptive immune responses (, NA)
• Long-Lasting and Transgenerational Effects of an Environmental Enrichment on Memory Formation (, NA)
• Estrogen Signaling in Hypothalamic Circuits Controling Reproduction (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Homo sapiens,Corynebacterium phage gamma)
• New targets in cancer cell metabolism are shown (, Homo sapiens,Mus musculus)
• Myoblast fusion during muscle development (, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Targeting the multistepped pathways of IL-1B–mediated inflammation (, NA)
• CMV-induced embryonic mouse organ of Corti dysplasia: network architecture of dysfunctional lateral inhibition (, Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,Bos taurus,Murid betaherpesvirus 1)
• Divergent evolutionary pathways of breast cancer progression (, Homo sapiens,Mus musculus,NA)
• miRNA biogenesis pathway (, NA)
• Proteome of sickle cell disease: insights from exploratory proteomic profiling (, NA)
• Notch signaling pathway depicted between two cells in the neocortical germinal zone (, NA)
• Complement cascade and its regulators (, Homo sapiens,Mus musculus,Rattus norvegicus,Papio hamadryas,Lareunionomyces loeiensis)
• Complement activation on allograft injury (, Homo sapiens,Mus musculus,Rattus norvegicus,Papio hamadryas,Lareunionomyces loeiensis)
• Programmed Cell Death in Animal Development and Disease (, Gallus gallus,Danio rerio,Xenopus laevis,Taeniopygia guttata,Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Programmed Cell Death in Animal Development and Disease (, Gallus gallus,Danio rerio,Xenopus laevis,Taeniopygia guttata,Drosophila melanogaster,Caenorhabditis elegans,Bombyx mori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Live to die another way: modes of programmed cell death and the signals emanating from dying cells (, NA)
• Hematologic malignancies: at the forefront of immunotherapeutic innovation (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Catopsilia pomona)
• Extrinsic and intrinsic pathways of cell death may activate during adipocyte hypertrophy and result in adipocyte cell death (, NA)
• Wnt Signaling in Dendritic Cells: Its Role in Regulation of Immunity and Tolerance (, Pseudomonas aeruginosa,Helicobacter pylori,Citrobacter rodentium,Homo sapiens,Mus musculus,Vaccinia virus)
• Autotaxin-LPA2 GPCR axis is modulated by Gamma-irradiation and facilitates DNA damage repair (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Dipturus trachyderma)
• Schematic diagram depicting how peroxynitrite (ONOO-) is generated by iNOS and NADPH oxidase to stimulate [LMW-Fe]i response from a chelatable pool of iron for activation of IKK and NFKB in LPS or TNFAlpha-treated macrophages (, NA)
• Ceramide metabolic pathways (, NA)
• CIB1 regulation of TNBC cell survival and potential role of CIB1 in non-oncogene addiction (, Homo sapiens,Mus musculus,Gallus gallus,Diaporthe sclerotioides,Human gammaherpesvirus 8)
• Numerous arrestin functions play a role in apoptosis and cell survival (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Hepatitis B virus)
• Hypothetical model illustrating p53 transgene mediated inhibition of Type I IFN signaling during VSV infection (, Human papillomavirus,Human papillomavirus type 16,Vesicular stomatitis virus,Vaccinia virus,Semliki Forest virus,Replication competent viruses,Canarypox virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Armoracia rusticana,Matthiola incana,Cricetus cricetus,Homo sapiens,Escherichia coli,Serinus canaria)
• An unexpected inhibition of antiviral signaling by virus-encoded tumor suppressor p53 in pancreatic cancer cells (, Human papillomavirus,Human papillomavirus type 16,Vesicular stomatitis virus,Vaccinia virus,Semliki Forest virus,Replication competent viruses,Canarypox virus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Armoracia rusticana,Matthiola incana,Cricetus cricetus,Homo sapiens,Escherichia coli,Serinus canaria)
• Apoptosis signaling pathways in cisplatin nephrotoxicity (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Escherichia coli,Danio rerio,Adeno-associated virus)
• Schematic model of regulation of PTPA by STEP61 during EtOH treatment in DMS (, Mus musculus,Rattus norvegicus,Marmota monax,Bos taurus,Capra hircus,Adeno-associated virus,Adeno-associated virus - 1,Homo sapiens,Gallus gallus)
• Combinatorial approach to suppression of cancer growth that employs 4-HPR and tamoxifen (, Aspergillus janus)
• Brain signaling network reprogramming in response to mild mitochondrial uncoupling (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Drosophila melanogaster,Gallus gallus,Canis lupus familiaris)
• Modulating effects of bioactive food components on niche signaling pathways and crosstalks among them in cancer stem cells (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Nicotiana tabacum,Camellia sinensis,Homo sapiens,Moloney murine leukemia virus)
• Significantly expressed genes in cytokine–cytokine receptor interaction pathway disturbed by SM at different time points (, Mus musculus,Rattus norvegicus,Schizosaccharomyces pombe,Human rhinovirus sp.,Homo sapiens)
• Vitamin D suppresses the Beta-catenin-dependent canonical Wnt pathway in both stem and non-stem colon cancer cells (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Nicotiana tabacum,Camellia sinensis,Homo sapiens,Moloney murine leukemia virus)
• Possible effects of soy isoflavone genistein and tea polyphenolic compound EGCG on the Wnt pathway in breast cancer stem cells (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Nicotiana tabacum,Camellia sinensis,Homo sapiens,Moloney murine leukemia virus)
• Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes (, NA)
• Simplified schematic representation of the apoptosis pathway in mammals and Drosophila (, NA)
• The evolutionarily conserved Wnt/Wingless signal transduction pathway (, NA)
• Metabolism, Cell Surface Organization, and Disease (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Arabidopsis thaliana,Bacillus subtilis At2,Triportheus paranensis,Reovirus sp.)
• Heatshock protein vaccines against Glioblastoma: From bench to bedside (, NA)
• B cell-derived cytokines direct the ensuing immune response (, NA)
• Canonical Notch signalling pathway and relevant pharmacological inhibitors under development in cancer (, NA)
• Canonical HH-signalling pathway and pharmacological inhibitors targeting this pathway that are under ongoing development as anticancer therapies (, NA)
• Canonical Wnt signalling pathway and pharmacological inhibitors under investigation in cancer (, NA)
• Integrating physiological regulation with stem cell and tissue homeostasis (, NA)
• Molecular Insight into Dengue Virus Pathogenesis and its Implications for Disease Control (, NA)
• Multifaceted Control of DNA Repair Pathways by the Hypoxic Tumor Microenvironment (, Mus musculus,Cricetulus griseus,Homo sapiens,unidentified shuttle vector)
• DNA Repair Deficiency and Neurological Disease (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Endogenous TRAIL function in multidrug-resistant cancer cells (, NA)
• Analogue 3 also showed potent antiproliferative activity against the highly invasive non-small-cell lung cancer cell line CL1-5 with an ED50 value of 0.11 μM (, NA)
• Interconnectivity of signaling pathways emanating from TLRs and TACI (, NA)
• Apoptotic signaling pathway induced by Licochalcone-A in head and neck squamous carcinoma FaDu cells (, NA)
• Dietary agents on the extrinsic and intrinsic pathways of apoptosis in prostate cancer (, Glycine max,Solanum lycopersicum,Malus domestica,Olea europaea,Vitis vinifera,Arachis hypogaea,Cucumis sativus,Curcuma longa,Camellia sinensis,Fragaria x ananassa,Allium cepa,Pisum sativum,Punica granatum,Citrus x paradisi,Mangifera indica,Carica papaya,Citrullus lanatus subsp. vulgaris,Polygonum cuspidatum,Prunus armeniaca,Lens culinaris,Trifolium pratense,Psidium guajava,Mus musculus,Rattus norvegicus,Homo sapiens,Triportheus paranensis)
• Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma (, NA)
• Significant edges for the proteins in the PI3K-AKT kinase pathway for breast (a) and ovarian cancer cell lines (b) computed using a Bayesian FDR of 0.10 (, Homo sapiens,Bos taurus)
• Conserved and differential networks for the proteins in the PI3K-AKT kinase pathway between breast and ovarian cancer cell lines computed using a Bayesian FDR set to 0.10 (, Homo sapiens,Bos taurus)
• Working model (, NA)
• Beta-arrestin: a signaling molecule and potential therapeutic target for heart failure (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy (, Homo sapiens)
• Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy (, Homo sapiens)
• Tendon Mechanobiology: Current Knowledge and Future Research Opportunities (, NA)
• Cellular alterations and molecular mechanisms involved in hepatic cystogenesis (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Bikinia letestui)
• Metabolic insulin signaling pathway genes genotyped in the discovery cohort (, NA)
• Antenatal Hypoxia and Pulmonary Vascular Function and Remodeling (, Homo sapiens)
• The regulation of IgA class switching (, NA)
• Antenatal Hypoxia and Pulmonary Vascular Function and Remodeling (, Homo sapiens)
• T-REX electrophile toolbox enables assessment of downstream signaling strength triggered by target-specific delivery of specific bioactive LDEs (1–10) to specific proteins in cells (e.g., Keap1) at a precise time (, NA)
• Quantitative phosphoproteomic analysis of IL-33 mediated signaling (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Proposed mechanisms of IL-6 and its receptor signaling pathway in SOCS-3 induction in cells with or without IL-6R (, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Roles for Growth Factors in Cancer Progression (, NA)
• Roles for Growth Factors in Cancer Progression (, NA)
• Basic biology and role of interleukin-17 in immunity and inflammation (, NA)
• Two different ubiquitin ligases control the stability of the Aurora-A and Polo-like kinases (, NA)
• The bifurcating parallel signal transduction pathways downstream of the IL-13R that regulate 15-LO gene expression in primary human monocytes (, NA)
• Antiviral Defense Mechanisms in Honey Bees (, NA)
• Extrinsic cell death pathway is typically triggered by members of the tumor necrosis factor (TNF) family of death receptor ligands, comprising TNF itself, Fas ligand, and TNF-related apoptosis-inducing ligand (TRAIL) (, Mus musculus,Rattus norvegicus,Hepatitis B virus,Vaccinia virus,Vasconcellea candicans,Phyllanthus urinaria,Homo sapiens,gut metagenome,NA)
• Current and Future Clinical Applications for Optical Imaging of Cancer: From Intraoperative Surgical Guidance to Cancer Screening (, Homo sapiens)
• Signaling pathway of focal adhesion (, NA)
• Signaling pathway of regulation of actin cytoskeleton (, NA)
• HIV increases HCV-induced hepatocyte apoptosis (, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus asinus,Armoracia rusticana,Human immunodeficiency virus 1,Human immunodeficiency virus,Matthiola incana,Homo sapiens,Mus musculus,NA)
• Summary of the potential mechanisms which may be involved in sustaining epithelial barrier function via the p-Akt signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• CX3CL1-induced breast carcinogenesis in ErbB2 transgenic mice (, NA)
• Bridging scales in cancer progression: Mapping genotype to phenotype using neural networks (, NA)
• Reflex control of immunity (, NA)
• Reflex control of immunity (, NA)
• Chromatin remodelling during development (, NA)
• Mammalian base excision repair and single-strand break repair pathways (, NA)
• Working model (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Pollachius virens)
• Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression (, NA)
• Proteostasis network (PN) (, NA)
• ErbB receptor signaling and regulation (, Homo sapiens)
• Targeting the embryonic gene Cripto-1 in cancer and beyond (, Mus musculus,Rattus norvegicus,Adenoviridae,Mouse mammary tumor virus,vectors,Simian-Human immunodeficiency virus,Homo sapiens,Gallus gallus,Capra hircus,Helicobacter pylori)
• TSC mediated signaling in the central nervous system (, NA)
• Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations (, Homo sapiens,Mus musculus)
• Proof of Concept: A review on how network and systems biology approaches aid in the discovery of potent anticancer drug combinations (, Homo sapiens,Mus musculus)
• Hypertension Induced by VEGF Signaling Pathway Inhibition: Mechanisms and Potential Use as a Biomarker (, NA)
• This cartoon summarizes our observations and integrates them into the context of previous studies (, Gallus gallus,Xenopus laevis,Xenopus tropicalis,Ambystoma mexicanum,Streptomyces globisporus,Streptomyces sp. CNB091,Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus)
• SP-mediated signaling and activation of the MAPK and MLC20 pathways in lymphatic muscle cells (, NA)
• Antiviral apoptotic pathway is mediated by IRF-3 and Bax (, Mus musculus,NA,Homo sapiens)
• Metabolic scheme depicting the involvement of different types of PLA2s in oxidative signaling pathways leading to neuronal impairment and glial cell inflammatory responses (, NA)
• Noonan syndrome and clinically related disorders (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Panthera pardus)
• Role of TOR signaling in aging and related biological processes in Drosophila melanogaster (, NA)
• Differences in M1- versus M2-macrophage fueling reactions (, NA)
• Schematic diagram illustrating an overview of cellular injury and inflammatory-mediated steps in development of leiomyoma as compared with uterine scar formation caused by mechanical injury (i.e., myomectomy and cesarean delivery) (, NA)
• ANTI-TGF-ß THERAPY IN FIBROSIS: RECENT PROGRESS AND IMPLICATIONS FOR SYSTEMIC SCLEROSIS (, NA)
• Autophagy in Immunity and Cell-Autonomous Defense Against Intracellular Microbes (, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Sindbis virus,Mycobacterium tuberculosis,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant africanum,Homo sapiens,Pan troglodytes,Gorilla gorilla,Saccharomyces cerevisiae,Drosophila melanogaster,Komagataella pastoris,Toxoplasma gondii,Mus musculus)
• Exploiting synthetic lethal interactions for the treatment of human cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Human immunodeficiency virus 1)
• Backup DNA repair pathway (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Human immunodeficiency virus 1)
• Pathways by which toll-like-receptor signals and ligation of FcG receptor lead to the production of interleukin (, NA)
• ANTI-TGF-ß THERAPY IN FIBROSIS: RECENT PROGRESS AND IMPLICATIONS FOR SYSTEMIC SCLEROSIS (, NA)
• Impaired brain insulin signaling in sporadic Alzheimer’s disease (sAD) pathology (, NA)
• Tumor Angiogenesis (, NA)
• Tumor Angiogenesis (, NA)
• Intricate mechanisms of neurodegeneration in prion diseases (, prion,Homo sapiens)
• Energy landscapes as a tool to integrate GPCR structure, dynamics and function (, Homo sapiens,Bos taurus)
• Roles of notch signaling in development and neurological disorders.The illustration depicts the canonical notch signaling pathway (center) and involvement in developmental processes (left) as well as adult neurological disorders (right) (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mustela putorius furo)
• Mammalian molecular clock and oscillation of mRNA and protein in peripheral tissues (, NA)
• Simplified schematic of the canonical Notch signaling pathway (, NA)
• Hsp27 Protects Adenocarcinoma Cells from UV-induced Apoptosis by Akt and p21 Dependent Pathway of Survival (, NA)
• Toll-like receptor signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hedgehog Signaling in the Liver (, NA)
• COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING (, NA)
• COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING (, NA)
• Interferons and other inflammatory cytokines control HBV infection of hepatocytes via multiple, distinct mechanisms (, NA)
• Metabolic pathway for DEG based on previous animal studies and on the results presented in this report (, NA)
• Decreased fatty acid oxidation contributes to CKD progression (, NA)
• Proposed model explaining upregulation of CREB expression by RA in NHTBE cells (, NA)
• Subtype-specific G protein coupling and function of B1 AR and B2 AR in cardiac myocytes (, NA)
• RIP1 COMES BACK TO LIFE AS A CELL DEATH REGULATOR IN TNFR1 SIGALING (, NA)
• Proposed pathways through which ethanol administration elicits alterations in cytokine gene expression (, NA)
• Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• HIF activation in cancer (, NA)
• Carney Complex: an update (, Escherichia coli,Escherichia coli IS5,Homo sapiens,Mus musculus,Bikinia letestui,Notolabrus celidotus)
• Major kinase signaling cascades involved in drug addiction (, NA)
• Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR (, NA)
• Multifunctional effects of CMKLR1 activation (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,unidentified influenza virus,Human immunodeficiency virus 2,Psammomys obesus,Homo sapiens,Diaporthe sclerotioides)
• Wnt signaling pathway activation in R1A deficient tumor cells (, Homo sapiens,Mus musculus,Mouse mammary tumor virus,Notolabrus celidotus)
• PURINERGIC SIGNALING IS REQUIRED FOR FLUID SHEAR STRESS-INDUCED NFKB TRANSLOCATION IN OSTEOBLASTS (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens)
• Schematic pathway of HIV-1 B and C differentially influence central nervous system (, NA)
• Core of the Hippo pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,NA,NA)
• Function of nuclear and cytoplasmic Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,NA,NA)
• Signal crosstalk with Yes-associated protein (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,NA,NA)
• Stem cell mechanobiology: diverse lessons from bone marrow (, NA)
• B cell receptor (BCR) signaling pathway and molecular interactions in the CLL microenvironment (, Homo sapiens,Mus musculus,Bikinia letestui)
• Soluble recombinant molecule consisting of the extracellular domains of CD80 linked to the Fc domain of Ig (soluble CD80 or CD80-Fc) has the potential to maintain and facilitate T cell activation through three independent mechanisms (, NA)
• Diagram shows the proposed signaling pathway exerting the adverse effect of ET-1 on endothelium-dependent, nitric oxide-mediated vasodilation (, NA)
• Differentially expressed genes in the MICs as compared to NSPCs (, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Candida dubliniensis,Python bivittatus,NA)
• Proteomic approaches to analyzing hepatitis C virus biology (, NA)
• WNT signaling in adult ovarian folliculogenesis (, NA)
• WNT signaling in adult ovarian folliculogenesis (, NA)
• TGFB Smad-independent Signaling Pathways: TGFB exerts its effect by binding and activating type II receptor (TGFBR2) and then type I receptor (TGFBR1) (, NA)
• TGFB Smad-dependent signaling pathway: TGFB exerts its effect by binding and activating type II receptor (TGFBR2) and then type I receptor (TGFBR1) (, NA)
• Emerging roles of YAP and TAZ in cancer (, Human gammaherpesvirus 8,Betapolyomavirus macacae,Merkel cell polyomavirus,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,NA)
• Emerging roles of YAP and TAZ in cancer (, Human gammaherpesvirus 8,Betapolyomavirus macacae,Merkel cell polyomavirus,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,NA)
• Emerging roles of YAP and TAZ in cancer (, Human gammaherpesvirus 8,Betapolyomavirus macacae,Merkel cell polyomavirus,Homo sapiens,Mus musculus,Drosophila melanogaster,Helicobacter pylori,NA)
• Transition of primordial to primary follicles (, NA)
• H2S-related pathomechanisms of diabetic endothelial dysfunction (, Mus musculus,Rattus norvegicus,Homo sapiens)
• New immunotherapies targeting the PD-1 pathway (, Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG,NA)
• New immunotherapies targeting the PD-1 pathway (, Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG,NA)
• Innate IgA-inducing signaling pathways (, NA)
• Architecture of intestinal TD and TI IgA responses (, NA)
• Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development (, NA)
• Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development (, NA)
• Proposed mechanisms of activation of proinflammatory signaling pathways in IFN-mediated autoinflammatory diseases (, NA)
• Mechanisms of NFKB-mediated diseases (, NA)
• Proposed model of the process of A20 (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• Regulation of Hedgehog signaling by ubiquitination (, NA)
• Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular mechanisms involved in nasopharyngeal carcinoma (NPC) development (, Homo sapiens,Mus musculus,Nicotiana tabacum,Human gammaherpesvirus 4,Catopsilia pomona)
• Learning and short-term memory depend on the cAMP pathway (, NA)
• Memory genes identified in model systems overlap with genes identified in human mental retardation (, NA)
• From bench to bedside: what do we know about Hormone Receptor-positive and Human Epidermal Growth Factor Receptor 2-positive breast cancer? (, Homo sapiens,Mus musculus)
• Type B coxsackieviruses and their interactions with the innate and adaptive immune systems (, NA)
• Snail repressor is required for PMC ingression in the sea urchin embryo (, Paracentrotus lividus,Parechinus angulosus)
• Enzymes involved in the synthesis of fumiquinazoline intermediates 14 and 18 (, NA)
• Key transduction molecules of ErbB signaling pathway known to regulate cardiomyocyte viability and function (, NA)
• Identifying genomic and developmental causes of adverse drug reactions in children (, NA)
• Control of cell cycle transcription during G1 and S phases (, NA)
• Surviving apoptosis: life-death signaling in single cells (, NA)
• New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics (, NA)
• CXCR3 Isoforms play functional roles in seemingly opposing directions (, NA)
• Differential effects of Calmodulin on two key K-Ras4B effector pathways (, Mus musculus,Cricetulus griseus,Cricetus cricetus,Homo sapiens)
• Classical (genomic) and non-classical (non-genomic) mechanisms of E2 action (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Taeniopygia guttata)
• Emerging concepts in the regulation of hematopoiesis by inflammatory signaling (, Escherichia coli,Staphylococcus aureus,Homo sapiens,Mus musculus,Danio rerio,Candida albicans)
• Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors (, NA)
• Vascular Actions of 20-HETE (, NA)
• NFKB activation pathways, emerging molecular targets for cancer prevention and therapy (, NA)
• An outline of the inhibition of type I IFN signaling pathways by viral proteins of KSHV (, NA)
• Calcium-mediated mechanisms of cystic expansion (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Canis lupus familiaris)
• Calcium-mediated mechanisms of cystic expansion (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Canis lupus familiaris)
• Calcium-mediated mechanisms of cystic expansion (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Canis lupus familiaris)
• Calcium-mediated mechanisms of cystic expansion (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Canis lupus familiaris)
• Dietary restriction, mitochondrial function and aging: from yeast to humans (, Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Arachis hypogaea)
• PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma (, NA)
• PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma (, NA)
• GPCR signaling overview (, Homo sapiens,Mus musculus,Arachis hypogaea)
• Cross-regulation of GPCR and Nox signaling pathways can induce cell death by apoptosis (, Homo sapiens,Mus musculus,Arachis hypogaea)
• Inflammatory signals regulate hematopoietic stem cells (, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Mycobacterium avium,Anaplasma phagocytophilum,Brucella melitensis,Ehrlichia chaffeensis,Drosophila melanogaster,Leishmania major,Plasmodium chabaudi,Vaccinia virus,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Candida albicans,clinical samples)
• Signaling pathways regulating dendritic spine actin remodeling with the induction of LTP by theta burst stimulation (TBS).Schematic of signaling pathways linking three classes of synaptic to regulation of the actin cytoskeleton (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Oryctolagus cuniculus)
• Evasion and Interactions of the Humoral Innate Immune Response in Pathogen Invasion, Autoimmune Disease, and Cancer (, Human immunodeficiency virus 1,Staphylococcus aureus,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Streptococcus pneumoniae,Vesicular stomatitis virus,West Nile virus,Streptococcus pyogenes,Bacillus anthracis,Ebola virus,Clostridium perfringens,Streptococcus mutans,Streptococcus sp. group A,Human adenovirus 5,H7N9 subtype,Streptococcus equi,Finegoldia magna,Streptococcus mutans SM6,Homo sapiens,Chlorocebus aethiops,Papio hamadryas,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Lareunionomyces loeiensis,NA,NA,NA,NA)
• Regulation of Innate Immunity by signaling pathways emerging from the endoplasmic reticulum (, Saccharomyces cerevisiae,Nicotiana tabacum,Pseudomonas aeruginosa,Francisella tularensis,Homo sapiens,Mus musculus,Caenorhabditis elegans,NA)
• Unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening (, NA)
• S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells (, Escherichia coli,Escherichia coli IS5,Homo sapiens)
• Targeting the HGF/c-MET Pathway in Hepatocellular Carcinoma (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Involvement of IAP proteins and IAP antagonists in the apoptosis and NFKB pathways [, ] (, NA)
• Temporal regulation of signaling events (, NA)
• Antiviral activities of Dicers(A) Domain architectures of Dicers from Drosophila melanogaster and Caenorhabditis elegans, and human (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• RecQ helicases in base excision repair (BER) and double-strand break repair (DSBR) (, NA)
• Neurohormetic Phytochemicals: An Evolutionary - Bioenergetic Perspective (, Saccharomyces cerevisiae,Armoracia rusticana,Nicotiana tabacum,Malus domestica,Olea europaea,Curcuma longa,Agaricus bisporus,Camellia sinensis,Theobroma cacao,Allium sativum,Musa acuminata,Punica granatum,Capsicum frutescens,Origanum vulgare,Vaccinium myrtillus,Garcinia mangostana,Gastrodia elata,Urtica dioica,Galanthus nivalis,Homo sapiens,Pan troglodytes,Microcebus murinus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans)
• Immunosuppressive and tumor-promoting functions of TAMs and MDSCs in HCC (, NA)
• Schematic view of bench-to-bedside aspects of colorectal cancer epigenetics (, NA)
• Schematic of the ERBB(EGFR)/KRAS/BRAF/MAPK signaling axis, and its connection with the PI3 Kinase pathway (, NA)
• Proteins oxidized by extracellular EhCySS control cell signaling and morphology (, NA)
• Putative pathways of catecholamine autotoxicity in a dopaminergic neuron (, NA)
• New biology of diabetes (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Canis lupus familiaris,Poromitra oscitans)
• Altered modulation of the IL-8 signaling pathway in AH livers with MDBs (, Oryctolagus cuniculus,Equus asinus,Homo sapiens,Mus musculus)
• Peptide vaccines and peptidomimetics targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy (, NA)
• Endoplasmic reticulum stress inducing autophagy (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Listeria monocytogenes)
• NUMB Mediates the Interaction between Wnt and Notch to Modulate Primitive Erythropoietic Specification from the Hemangioblast (, Drosophila melanogaster,Oryctolagus cuniculus,Equus asinus,Paracentrotus lividus,Homo sapiens,Mus musculus,Gallus gallus,Pyrus communis)
• Involvement of LRP6 in the PTH-stimulated anabolic bone effect (, Bos taurus,Oryctolagus cuniculus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Myc-regulated metabolic pathways in cancer (, NA)
• T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics (, NA)
• T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics (, NA)
• The IGF-1R signaling network and nodes of therapeutic blockade (, Homo sapiens,Lareunionomyces loeiensis)
• Strategies to increase flux of non-natural analogs into glycosylation pathways (, NA)
• Cellular interactions in normal and diseased vasculature (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Corynebacterium phage gamma)
• Innate immune interactions within the central nervous system modulate pathogenesis of viral infections (, Human alphaherpesvirus 1,Vesicular stomatitis virus,West Nile virus,Enterovirus C,Japanese encephalitis virus,Sindbis virus,Lyssavirus rabies,La Crosse virus,Langat virus,Homo sapiens,Mus musculus,Equus caballus,NA,NA,NA)
• PI3K/Akt and RAS/BRaf/MEK pathways are frequently altered in melanoma (, Homo sapiens,Mus musculus)
• Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors (, Homo sapiens,Drosophila melanogaster)
• Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer (, NA)
• Activation of the PI3K/Akt pathway in cancer (, Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Cancer-promoting GSNs in A) D-SWCNT, B) D-MWCNT and C) ASB neoplastic-like transformed SAECs (, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Armoracia rusticana,Sequoia sempervirens,Homo sapiens,Bos taurus)
• Major pathways of lipid metabolism in yeast (, NA)
• Mutations in non-essential genes affecting stress response pathways confer Ino− phenotypes (, NA)
• Stimulating progress in regenerative medicine: improving the cloning and recovery of cryopreserved human pluripotent stem cells with ROCK inhibitors (, NA)
• Nicotine Modulation of Fear Memories and Anxiety: Implications for Learning and Anxiety Disorders (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Oryctolagus cuniculus,Nicotiana tabacum)
• Wnt Signaling in Bone and Muscle (, NA)
• Interaction between PI3K/Akt and Wnt signaling pathways mediates diverse cellular effects through downstream messengers (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of IGF-I Signaling in Muscle Bone Interactions (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia (, Homo sapiens,Macaca fascicularis,Mus musculus)
• Life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics (, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Murid betaherpesvirus 1,Murid gammaherpesvirus 4,Human betaherpesvirus 6A,Macacine betaherpesvirus 3,Human herpesvirus 5 strain AD169,Rhesus cytomegalovirus strain 68-1,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,NA)
• Simplified model of nutrient signaling pathways influencing metabolic responses (, NA)
• Gene expression profile (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana,Enterovirus C)
• Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression (, NA)
• Targeting Fas in osteoresorptive disorders (, Cryptococcus neoformans,Epimedium koreanum,Homo sapiens,Mus musculus)
• Mapk signaling pathway from KEGG (, Homo sapiens,Rattus norvegicus)
• Regulatory network governing mitochondrial functions orchestrated by PGC-1A (, NA)
• Eicosanoid Storm in Infection and Inflammation (, NA)
• Eicosanoid Storm in Infection and Inflammation (, NA)
• Metaproteomics Reveals Functional Shifts in Microbial and Human Proteins During a Preterm Infant Gut Colonization Case (, Candidatus Arthromitus sp. SFB-mouse,Nanoarchaeum equitans,Ignicoccus hospitalis,Leuconostoc mesenteroides subsp. cremoris,Varibaculum cambriense,Saccharomyces cerevisiae,gut metagenome,human gut metagenome,Saccharomyces cerevisiae UC5,Homo sapiens,Bacteriophage sp.)
• PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca2+ Mobilization and Synergistic P2Y12 Receptor Activation (, Homo sapiens)
• WNKs: atypical protein kinases with pleiotropic actions (, Gallus gallus,Danio rerio,Xenopus laevis,Xenopus tropicalis,Lithobates catesbeianus,Xenopus sp.,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Giardia intestinalis,Rattus rattus,Oryza sp.,Homo sapiens,Mouse mammary tumor virus)
• Cell Cycle Regulators and Cell Death in Immunity (, Saccharomyces cerevisiae,Arabidopsis thaliana,Golovinomyces orontii,Homo sapiens,Pseudomonas syringae)
• Mapping the pathways of resistance to targeted therapies (, NA)
• Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Simplified model of a cell signaling process highlighting the flow from signals generated externally by epidermal growth factor (EGF) to the activation or repression of transcription (, Escherichia coli,Mycobacterium tuberculosis,Mycobacterium tuberculosis H37Rv,Homo sapiens,human metagenome)
• Bile acid metabolism and signaling in cholestasis, inflammation and cancer (, NA)
• Activation of the B2AR with isoproterenol increases cAMP with subsequent PKA activation (, NA)
• Summary of unfolded protein response and endoplasmic reticulum stress signaling pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Candida dubliniensis,Ovis aries,Ipomoea batatas,Nelumbo nucifera,Cajanus cajan,Homo sapiens,Mus musculus,Rattus norvegicus,Danio rerio,Calloplesiops altivelis,Sapajus apella,Porcine epidemic diarrhea virus,NA)
• Model depicting Dcp1-mediated translational repression in endotoxin-tolerant cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Escherichia coli,Staphylococcus aureus,Homo sapiens,Mus musculus)
• Adapted from KEGG colorectal cancer pathway [, , ] (, NA)
• Everolimus Combined With Gefitinib in Patients with Metastatic Castration-Resistant Prostate Cancer: Phase I/II Results and Signaling Pathway Implications (, Homo sapiens,Mus musculus)
• MTOR pathway as a central signaling pathway causing malformations of cortical development and epilepsy (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathogenesis of Muscle Wasting in Cancer Cachexia: Targeted Anabolic and Anti-Catabolic Therapies (, Homo sapiens,Oryctolagus cuniculus)
• TRANSLATIONAL IMPLICATIONS OF ENDOTHELIAL CELL DYSFUNCTION IN ASSOCIATION WITH CHRONIC ALLOGRAFT REJECTION (, NA)
• NF-kappaB, a mediator for lung carcinogenesis and a target for lung cancer prevention and therapy (, NA)
• Inflammatory bowel disease (IBD) as a multifactorial disorder (, Homo sapiens)
• Modeling the calcium-mediated pro-apoptotic action of less toxic natural products (, NA)
• RAGE signaling pathways (, NA)
• The Ca2+ dependent signaling pathway activated by PAR2 (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Regulatory mechanisms of ectodomain shedding (, NA)
• Dynamic Distribution of CARD11 at the Immunological Synapse is Regulated by the Inhibitory Kinesin GAKIN (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,vectors)
• Remote Ischemic Preconditioning for Kidney Protection (, NA)
• The paracellular pathway in vertebrates and insects (, Aedes aegypti,Homo sapiens)
• Signaling pathways induced following CB2 engagement with cannabinoid ligands (, NA)
• MTORC1 and mTORC2 signaling branches (, NA)
• Molecular mechanisms activated by tumor necrosis factor-alpha (TNFA) which causes hypercontractility of cavernosal smooth muscle cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Comparison of typical innate immune signaling cascades (top panel) with those activated by CJD infection (bottom panel) (, NA)
• Notch signaling pathway (, NA)
• Distinct signaling pathways induced by rhTum and rhEndo (, NA)
• Signal transduction pathway for delayed onset potentiation of the NMDA response by PregS (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Xenopus laevis,Cannabis sativa)
• Nuclear and cytosolic pathways controlling nuclear Ca2+ homeostasis in cardiomyocytes (, NA)
• IL-27-induced modulation of autoimmunity and its therapeutic potential (, NA)
• IL-27-induced modulation of autoimmunity and its therapeutic potential (, NA)
• Working model of cellular mechanisms giving rise to pLTF (, NA)
• Impact of Aging on Dendritic Cell Functions in humans (, NA)
• Regulation of the JAK-STAT signaling pathway (, NA)
• TLR and NFKB signaling disrupted by PID (, Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Measles morbillivirus,Human alphaherpesvirus 2,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Haemophilus influenzae,Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• MTOR pathway (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Hippospongia communis,Homo sapiens,Bikinia letestui)
• Diagram of Hh signaling in mammalian cells (, Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• Different roles of Hh signaling in cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• KIT-mediated signaling events (, Mus musculus,Rattus norvegicus,Homo sapiens,Arachis hypogaea)
• Epigenetic Mechanisms in Schizophrenia (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Homologous recombination deficiency: Exploiting the fundamental vulnerability of ovarian cancer (, NA)
• APOBEC3B upreglation by the PKC-NFKB pathway.PKCA activation by DAG or PMA leads to IKKA phosphorylation and proteasome-dependent cleavage of NFKB subunit p100 into the transcriptionally active p52 form (, Human immunodeficiency virus 1,Hepatitis B virus,Human papillomavirus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• A) Proposed response of CTCL cells with downregulated/absent expression of death receptors/ligands to conventional ALA-PDT (, NA)
• ERBB signaling pathway is highly activated in AA PCa specimens (, NA)
• Ibrutinib: a first in class covalent inhibitor of Bruton’s tyrosine kinase (, Homo sapiens,Mus musculus,Canis lupus familiaris)
• MDA-7/IL-24: Multifunctional Cancer Killing Cytokine (, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Canis lupus familiaris,Erythroxylum coca,Homo sapiens)
• Schematic diagram showing the convergence of WNT and NOTCH signaling onto cell cycle regulation (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Equus asinus,clinical samples,Microbacterium aurantiacum)
• Molecular regulation of osteoclast survival: In WT osteoclast, both RANK and Ras-Raf-1-MEK-ERK signaling contribute to cell survival, but survival is mainly regulated by Src-Cbl-PI3K pathway (, Homo sapiens,Mus musculus,Bos taurus)
• mTORC2 signaling controls metabolic reprogramming in GBM: mTORC2 reprograms the glycolytic metabolism, lipid, glutamine, nucleotide and ROS metabolism mainly through Akt and c-Myc (, NA)
• Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer (, Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Immunological Basis in the Pathogenesis and Treatment of Bladder Cancer (, Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Activation of the complement cascade and its role in tumorigenesis (, NA)
• Cartoon diagram of the hypothesized effects of mechanical loading, with or without LVAD support, on cardiac 7-TMR/GPCR signal transduction (, Homo sapiens,Rattus norvegicus,Ovis aries)
• Microhomology-mediated end joining: a back-up survival mechanism or dedicated pathway? (, Saccharomyces cerevisiae,Arabidopsis thaliana,Schizosaccharomyces pombe,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Protein kinase A signaling (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Gaining insights into diabetic cardiomyopathy from Drosophila (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Inhibition of YAP/TAZ transcriptional coactivators by LATS1/2 (, NA)
• Regulation of the Hippo pathway in Drosophila (, NA)
• Regulation of the Hippo pathway in mammals (, NA)
• Therapeutic targeting of the Hippo pathway (, NA)
• Multiple Effects of RASSF1A (, Escherichia coli,Arabidopsis thaliana,Citrus macrophylla,Methanocorpusculum labreanum,Homo sapiens,Mus musculus,unidentified,Triportheus paranensis,NA)
• Rapid Antidepressant Actions of Scopolamine: Role of Medial Prefrontal Cortex and M1-subtype Muscarinic Acetylcholine Receptors (, Oryctolagus cuniculus,Capra hircus,Pekania pennanti,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Combination Treatment with Progesterone and Vitamin D Hormone May Be More Effective than Monotherapy for Nervous System Injury and Disease (, NA)
• PDEs 1–4 (orange symbols) hydrolyze cAMP (yellow shaded background) generated by the Beta-adrenergic signaling pathway (red shaded background) (, NA)
• Paradigm for testing the multiple independent mechanisms that reinforce IDO1-mediated immunosuppression in malignant glioma (, NA)
• Differential Somatostatin Receptor (SSTR) 1-5 Expression and Downstream Effectors in Histologic Subtypes of Growth Hormone Pituitary Tumors3.1 (, NA)
• Mammalian target of rapamycin complex 1 (mTORC1) is required for mouse spermatogonial differentiation in vivo (, NA)
• NF2 loss promotes oncogenic RAS-induced thyroid cancers via YAP-dependent transactivation of RAS proteins and sensitizes them to MEK inhibition (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Cell positioning and signaling compensate for stochastic lateral inhibition in the worm vulval developmental pathway (, Escherichia coli,Bacillus subtilis,Escherichia coli K-12,Streptococcus pneumoniae,Bacillus subtilis At2,Haemophilus influenzae,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Signaling pathways associated with CRKL, GAB2, and FRS2.CRKL is activated by multiple types of cell surface receptors including integrin receptors upon binding to extracellular matrix (ECM), cytokine receptors, and growth factor receptors (, Influenza A virus,Mouse mammary tumor virus,Homo sapiens,Mus musculus,Corynebacterium phage gamma)
• Proposed signaling mechanisms of S100A8/A9 in pancreatic-cancer cells.S100A8/A9 could interact with RAGE, leading to the activation of MAP kinases and NF̃KB signaling (, NA)
• The role of S100 proteins and their receptor RAGE in pancreatic cancer (, NA)
• Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases (, NA)
• Signaling schematic depicting our hypothesis of how adenosine regulates HCASMC cell-cycle progression (, NA)
• Hippo signaling pathway and main regulators (, NA)
• Steps in the macroautophagy pathway (, NA)
• PLA2 may mediate excitotoxicity, cerebrovascular dysfunction and oxidative stress in AD (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed pathway of prostaglandin synthesis and interaction with the cyclooxygenase pathways and VEGFA (, Mus musculus,Rattus norvegicus,Mus musculus domesticus,Bos taurus,Capreolus capreolus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Mouse mammary tumor virus)
• Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway targetgenes and promote cell migration (, Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana,Turdus migratorius,murine stem cell retroviral vector)
• Mevalonate pathway, NHRs and immunity (, NA)
• Targeting IL4/IL4R for the treatment of epithelial cancer metastasis (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Three major signaling pathways that regulate cell size in normal cells.A (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Equus caballus,Betapolyomavirus macacae)
• Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells (, NA)
• Metabolic and non-cognitive manifestations of Alzheimer’s disease (, NA)
• Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer (, NA)
• Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer (, NA)
• Establishment and Dysfunction of the Blood-Brain Barrier (, NA)
• Skeletal muscle as an endocrine organ: PGC-1A, myokines and exercise (, Bos taurus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens)
• TGF-Beta-activated non-Smad pathways in epithelial-mesenchymal transition (, NA)
• Smad complexes can cooperate with transcription pathways in the control of gene expression in epithelial-mesenchymal transition (, NA)
• Architecture and signaling of the Drosophila testis niche (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Oryzias latipes,Homo sapiens)
• Physiological regulation of the mTOR signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Alcohol-induced TLR4 protein recruitment mediates the activation of Src kinase signaling pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Escherichia coli,Staphylococcus epidermidis,Homo sapiens)
• Molecular pathogenesis and potential treatments for thrombotic microangiopathy in the glomerular endothelium (, Human betaherpesvirus 6,Human parvovirus B19,Betapolyomavirus hominis,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli O104H4)
• Complexity of the direct and indirect effects of mTOR on signaling pathways (, NA)
• Proteins implicated in Parkinson’s disease (PD) maintain a healthy pool of mitochondria (, NA)
• RPE Necroptosis in Response to Oxidative Stress and in AMD (, NA)
• Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53 (, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Capra hircus,Panax ginseng,Panax quinquefolius,Homo sapiens,Mus musculus)
• Hedgehog Signaling in Fibrogenic Liver Repair (, NA)
• RPE Necroptosis in Response to Oxidative Stress and in AMD (, NA)
• Proposed opposing modulation of the AMPK pathway for energy homeostasis by utilizing the AMPK pathway (, Xiphophorus maculatus,Homo sapiens)
• Oncogenes strike a balance between cellular growth and homeostasis (, NA)
• Current working model of convergent pathways to PMF (, NA)
• The integration of the DUOX2 system into the intestinal epithelial defense response (, NA)
• Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases (, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,Japanese encephalitis virus,Influenza A virus H3N2,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Druggable Sensors of the Unfolded Protein Response (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,prion,Coxsackievirus B3)
• TLR4 and TLR3 sensitization (, Mus musculus,Rattus norvegicus,Cavia porcellus,Mus saxicola,Escherichia coli,Oryctolagus cuniculus,Diaporthe sclerotioides,Candida dubliniensis,Ovis aries,Ureaplasma parvum,Homo sapiens,Gallus gallus)
• Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain (, NA)
• Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7 (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Saccharomyces cerevisiae S288C,Homo sapiens,synthetic construct)
• Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission (, Saccharomyces cerevisiae,Saccharomyces cerevisiae S288C,Homo sapiens)
• Functional significance of itpkc_3 on ITPKC mRNA and Ca2+/NFAT pathway (, Homo sapiens,Staphylococcus aureus)
• The Ras signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Armoracia rusticana,Clinitrachus argentatus)
• Described mechanisms involved in steroid hormone regulation of cancer stem cell populations (, NA)
• GPC5 Gene and Its Related Pathways in Lung Cancer (, Homo sapiens,Mus musculus,clinical samples)
• Schematic diagram shows major signaling pathways stimulated by IFNA/B (mediated by the type I IFN receptor) and viral pathogen-associated molecular patterns (PAMPs) and/or ICs-containing nucleic acids (mediated by endosomal TLRs) (, Homo sapiens,Human alphaherpesvirus 1,Macaca mulatta,DNA viruses,Pan troglodytes,Human alphaherpesvirus 2,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Eutheria)
• Glutamate Metabolism in the Brain Focusing on Astrocytes (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• [U-13C]Glutamate (GLU) may be completely metabolized to CO2 via the “pyruvate recycling pathway” (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• MAPK pathway has been invoked in phospholipase A2 activity that could release arachidonic acid, perhaps in concert with VEGF, and thereby amplify 20-HETE formation () (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Citrobacter rodentium)
• Cancer Cell Dormancy – Another Hallmark of Cancer? (, NA)
• Targeting BCR signaling attenuates homing, survival, EMDR and MRD of malignant B cells (, Homo sapiens,Mus musculus)
• Composite figure from all time points of microarray data showing apoptotic pathways in HepG2 cells when exposed to PCB-153 (70μM) and PCB-77 (70μM) (, Armoracia rusticana,Brassica oleracea,Iris germanica,Bos taurus,Capra hircus,Homo sapiens,Rattus norvegicus)
• Role of Innate and Adaptive Immunity in Cardiac Injury and Repair (, NA)
• Proteomics Perspective on Viral DNA Sensors in Host Defense and Viral Immune Evasion Mechanisms (, NA)
• Simplified outline of Insulin and AA/TOR signaling pathways (, Drosophila melanogaster,Bombyx mori,Apis mellifera,Aedes aegypti,Tribolium castaneum,Blattella germanica,Saccharomyces cerevisiae,Bos taurus,Homo sapiens)
• Emerging Role of ABL Kinases in Solid Tumors (, NA)
• Adapters in the organization of mast cell signaling (, NA)
• Ingenuity Pathway Analysis of the subset of day-one genes that differentiate long-term success or failure, divided into two groups (F and G) following an unsupervised cluster analysis (, NA)
• Complement System and Antibody Mediated Transplant Rejection (, NA)
• Neuron in Alzheimer’s disease (, NA)
• MicroRNA interactome in metabolic homeostasis (, NA)
• Wiring diagram of selected elements of the yeast mating pheromone response pathway (see text for details) (, NA)
• Schematic cartoon of selected elements of the yeast mating pheromone response pathway (see text for details) (, NA)
• G-Protein Signaling: A New Branch in an Old Pathway (, Saccharomyces cerevisiae,Homo sapiens)
• Specificity of MAP Kinase Signaling in Yeast Differentiation Involves Transient versus Sustained MAPK Activation (, Saccharomyces cerevisiae,Homo sapiens)
• Schematic illustartion of microglial (A) and astrocytic (B) events taking place in the spinal cord in neuropathic pain (, Mus musculus,Rattus norvegicus,Homo sapiens,Antarctothoa delta)
• Transcriptional and chromatin regulation during fasting – The genomic era (, NA)
• The p38MAPKsignalling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Canis lupus familiaris,Candida dubliniensis,unidentified)
• In human primary macrophages, zymosan activates a calcium-dependent CaMKII–Pyk2–ERK signaling pathway downstream of Dectin-1 and ITAM-associated kinases Src and Syk (, Saccharomyces cerevisiae,Candida albicans,Pneumocystis carinii,Homo sapiens,Mus musculus)
• Proposed pathway for the metabolism of efavirenz to a nephrotoxic metabolite(s), which is believed to result from activation of the cysteine conjugate, either through S-oxidation (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Equus caballus,Felis catus,Homo sapiens,Mus musculus,Rattus norvegicus,Solanum tuberosum,Macaca fascicularis,Ipomoea batatas,Human immunodeficiency virus)
• Therapeutic control of complement activation at the level of the central component C3 (, NA)
• The PPARG signaling pathway in human macrophages in response to virulent M (, Mycobacterium tuberculosis,Homo sapiens)
• And B, top two networks of proteins eliciting a significantly elevated (P < 0.01; mean ratio > 2) response in C3(1)-T TNBC mouse model samples collected before palpable tumor compared with baseline, based on Ingenuity Pathway Analysis (, NA)
• A-Kinase Anchoring Proteins: Getting to the heart of the matter (, NA)
• Upper panel (, NA)
• Contribution of Metabolic Reprogramming to Macrophage Plasticity and Function (, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens)
• Contribution of Metabolic Reprogramming to Macrophage Plasticity and Function (, Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens)
• Cell-intrinsic versus cell-extrinsic control of metastatic progression by miRNAs (, Homo sapiens,Mus musculus,clinical samples,NA)
• The interaction between cPLA2A and TGFBsignaling pathways in hepatic cells (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Myeloid-specific GPCR kinase-2 negatively regulates NFKB1p105-ERK pathway and limits endotoxemic shock in mice (, NA)
• mTOR and its tight regulation for iNKT cell development and effector function (, Homo sapiens,Mus musculus,Catopsilia pomona)
• mTOR and its tight regulation for iNKT cell development and effector function (, Homo sapiens,Mus musculus,Catopsilia pomona)
• BCR, BAFFR and TACI crosstalk (, Homo sapiens,Mus musculus,Middle East respiratory syndrome-related coronavirus,Catopsilia pomona)
• Critical role of toll-like receptors - From microbial recognition to autoimmunity: A comprehensive review (, Staphylococcus aureus,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Bartonella quintana,unidentified influenza virus,H1N1 subtype,West Nile virus,Homo sapiens,Mus musculus,Danio rerio,Candida dubliniensis,Trypanosoma cruzi)
• Transcriptional regulation of T cell metabolism (, NA)
• Biosynthetic pathway of sphingolipids that mediate expressions of genes associated with cellular processes in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Cerobasis alpha)
• Resolvins: Natural Agonists for Resolution of Pulmonary Inflammation (, NA)
• Regulation of glucose-dependent insulin secretion in the Beta-cell (, NA)
• Adiponectin Regulates Bone Marrow Mesenchymal Stem Cell Niche through a Unique Signal Transduction Pathway - An Approach for Treating Bone Disease in Diabetes (, NA)
• Patient-specific Immune States before Surgery are Strong Correlates of Surgical Recovery (, NA)
• Sites of action for inhibitors and shRNAs in the EGFR-PI3K-Akt-mTOR pathway (, NA)
• PI3 kinase signaling pathway in glioma (, NA)
• Estrogen Receptor Activation and Cardioprotection in Ischemia Reperfusion Injury (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus caballus,Homo sapiens)
• RAS, an intracellular G protein, is phosphorylated, leading to activation of RAF (depicted as BRAF) (, Homo sapiens,Mus musculus,Drosophila melanogaster,Pyrus communis,Streptomyces spiroverticillatus)
• Phosphatidylinositol 3-kinase-Akt (PI3K-Akt) pathway becomes activated via stimulation of receptor tyrosine kinases (RTKs) and the assembly of receptor–PI3K complexes (, Homo sapiens,Mus musculus,Drosophila melanogaster,Pyrus communis,Streptomyces spiroverticillatus)
• Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles (, Treponema denticola,Homo sapiens)
• Cell cycle pathway containing Treponema denticola differentially regulated genes in calvarial bone compared with sham-infected controls at P ≤ 0.05, adapted from Pathway Express and using the Kyoto Encyclopedia of Genes and Genomes nomenclature (, Treponema denticola,Homo sapiens)
• Molecular characterization of Treponema denticola infection-induced bone and soft tissue transcriptional profiles (, Treponema denticola,Homo sapiens)
• Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy (, Homo sapiens,Mus musculus)
• Oxidative stress induces ABC efflux transporter expression (, NA)
• Vaccines against Gonorrhea: Current status and Future Challenges (, NA)
• Integration of Akt and mTORC1 signaling into the IL-4R and TLR4 pathways (, Saccharomyces cerevisiae,Candida dubliniensis,Salmonella enterica subsp. enterica serovar Typhimurium,Brucella abortus,Homo sapiens,Mus musculus)
• Simplified scheme of sulfur metabolism with an emphasis on the H2S-generating reactions (, NA)
• Mitochondrial sulfide oxidation pathway (, NA)
• Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Panthera pardus)
• The signaling cascade from PLD to HDM2 (, NA)
• Cellular and molecular scheme for an adaptive immune axis leading to acute lung disease after viral infection (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Respiratory syncytial virus,Human metapneumovirus,Homo sapiens,NA)
• Inflammatory targets of therapy in sickle cell disease (, NA)
• Chemoproteomics reveals novel protein and lipid kinase targets of clinical CDK4/6 inhibitors in lung cancer (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus)
• Integrated, multi-cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses (, Hepatitis B virus,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,H3N2 subtype,Human rhinovirus sp.,Human betaherpesvirus 6,SARS coronavirus NS-1,H7N7 subtype,Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,Staphylococcus aureus Chi-4,Homo sapiens,Sus scrofa,NA)
• Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer (, NA)
• Apoptotic cell recognition receptors and scavenger receptors (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Candida dubliniensis,Homo sapiens,Mus musculus,Bos taurus,Danio rerio,Staphylococcus aureus,Hepatovirus A,NA)
• Endosomal Toll-like Receptors in Clinically Overt and Silent Autoimmunity (, NA)
• Pancreatic Cancer Metabolism - Breaking it down to build it back up (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Plasmid pTF1)
• A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets (, Sequoia sempervirens,Citrus macrophylla,Homo sapiens,Mus musculus,Bos taurus)
• Recent advances on viral manipulation of NFKB signaling pathway (, NA)
• Recent advances on viral manipulation of NFKB signaling pathway (, NA)
• Dysregulation and restoration of translational homeostasis in fragile X syndrome (, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus)
• Wnt canonical and non-canonical pathways (, NA)
• Targeting the Wnt signaling pathways in pulmonary arterial hypertension (, NA)
• Androgen pathway resistance in prostate cancer and therapeutic implications (, Homo sapiens,Mus musculus)
• Colorectal Cancer Molecular Biology Moves Into Clinical Practice (, Homo sapiens,Mus musculus,clinical samples)
• Pathways of contraction and relaxation in cavernosal smooth-muscle cells (, NA)
• Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Chemical disruption of Wnt-dependent cell fate decision-making mechanisms in cancer and regenerative medicine (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• CAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis (, Saccharomyces cerevisiae,Oryza sativa,Zea mays,Cryptococcus neoformans,Ustilago maydis,Zea diploperennis,Cryptococcus neoformans var. grubii,Homo sapiens,Mus musculus)
• THC induces apoptosis in Jurkat cells via three different mechanisms (, NA)
• Schematic diagram showing the inhibitory effects of triptolide on oxaliplatin induced upregulation of nucleotide excision repair pathway (, herbal medicine,Tripterygium wilfordii,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli)
• Epac activation sensitizes rat sensory neurons via activation of Ras (, NA)
• Smad complexes is a core event in TGFB mediated growth suppression (, NA)
• Glutamate receptors as therapeutic targets for Parkinson’s disease (, NA)
• Hypoxia and hypoxia-inducible factors (HIFs): master regulators of metastasis (, NA)
• Working model illustrating the putative regulatory pathway in pancreatic cancer stem cells that is stimulated by nicotine and inhibited by GABA (, Homo sapiens,Mus musculus,Bos taurus)
• Fucose is on the TRAIL of colon cancer (, Mus musculus,Cricetulus griseus,Aspergillus oryzae,Aleuria aurantia,Homo sapiens)
• Innate Immunity against Leishmania Infections (, NA)
• Key signaling pathways involved in minocycline-mediated protection of cardiac myocytes from apoptosis trigged by in utero cocaine exposure (, NA)
• Signaling pathways in melanoma (, Homo sapiens,Mus musculus,Dipturus trachyderma,Mycobacterium tuberculosis variant bovis BCG)
• Distinct B1 and B3 integrin pathways converge to regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Moloney murine leukemia virus,Escherichia coli BL21)
• Schematic depiction of the pathway for CaMK-dependent signaling (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Molecular Pathways: Turning Proteasomal Protein Degradation into a Unique Treatment Approach (, NA)
• Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Porphyromonas gingivalis,Salmonella enterica subsp. enterica serovar Minnesota,Homo sapiens,Mus musculus,Eucalyptus intertexta,Leishmania major)
• FLCN pathway (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Negative regulation of TLR signaling in myeloid cells—Implications for autoimmune diseases (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Porphyromonas gingivalis,Salmonella enterica subsp. enterica serovar Minnesota,Homo sapiens,Mus musculus,Eucalyptus intertexta,Leishmania major)
• Controlling the burn and fueling the fire - defining the role for the alarmin IL-33 in alloimmunity (, Homo sapiens,Mus musculus,Canis lupus familiaris,unidentified influenza virus)
• Complex regulation of HSC emergence by the Notch signaling pathway (, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pathophysiology of Cardiac Toxicity from Various Chemotherapeutics and Role of Preventative Therapies (, NA)
• Toll-like receptor signaling pathways containing P (, NA)
• MHC class II antigen processing pathways containing P (, NA)
• Sarcoplasmic reticulum Ca2+ ATPase as a therapeutic target for heart failure (, Adeno-associated virus,adeno-associated virus 2,Human adenovirus sp.,Adeno-associated virus - 1,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Ovis aries,Cavia porcellus,Homo sapiens)
• NOD-like receptor signaling beyond the inflammasome (, NA)
• Calcineurin-NFAT pathway: Activation and regulation (, NA)
• Promotion of cancer development and progression by NFAT (, NA)
• SUMO — A post-translational modification with therapeutic potential? (, NA)
• Inhibition of the calcineurin-NFAT pathway at multiple levels (, NA)
• HSC aging and senescent immune remodeling (, Clostridioides difficile,Lactiplantibacillus plantarum,Clostridioides difficile CD3,Clostridioides difficile CD8,Human gammaherpesvirus 4,Human betaherpesvirus 5,H1N1 subtype,Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways of cytokines in GnRH neurons (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Acquisition of Estrogen Independence Induces TOB1-Related Mechanisms Supporting Breast Cancer Cell Proliferation (, NA)
• Decorin effects as an antiproliferative (left panel) and proliferative (right panel) molecule (, NA)
• Top biological network generated by Ingenuity Pathway Analysis for differentially expressed proteins of (A) ALDH+/CD44+CD24−, (B) ALDH+/CD49f-EpCAM+ and (C) CD44+CD24−/CD49f-EpCAM+ (, NA)
• Hypoxia-Inducible Factor-1: A critical player in the survival strategy of stressed cells (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Caenorhabditis elegans,Carassius auratus)
• Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: implications for disease pathogenesis and treatment (, NA)
• PECAM-1 Isoforms, eNOS, and Endoglin Axis in Regulation of Angiogenesis (, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens)
• Therapeutic Interventions to Disrupt the Protein Synthetic Machinery in Melanoma (, NA)
• Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? (, Homo sapiens)
• Novel promising anti-inflammatory therapies (, NA)
• Pathway and Network Analysis of Cancer Genomes (, Homo sapiens)
• Translational metabolomics in cancer research (, NA)
• Model Depicting major molecules and events in mast cell activation (, Mus musculus,Rattus norvegicus,Homo sapiens,Polydactylus virginicus)
• Screen shot of the user interfaceofSimmune2.0 (, Homo sapiens,Mus musculus)
• Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications (, Homo sapiens)
• Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications (, Homo sapiens)
• Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications (, Homo sapiens)
• Signaling crosstalk between the TGF-Beta-activated Smad pathway and the Wnt- and Notch-activated signaling pathways during EMT (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Sus scrofa)
• The canonical NFKB signaling pathway (, NA)
• DDN, (b) GDNMES, and (c) GDNnon-MES of Integrin AIIb B3 signaling (M760) pathway (, NA)
• DDN, (b) GDNPN, and (c) GDNnon-PN of PI3K events in ERBB2 signaling (M570) pathway (, NA)
• Chromatin modification upon growth factor stimulation and the effect of small molecule inhibitors (, NA)
• Positioning NFKB in multiple myeloma (, NA)
• Network of genes located within high-level copy number changes and deregulated across all of the cell lines and tumors (, Homo sapiens,Citrus macrophylla)
• AKT/MTOR pathway (, Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Ectopleura larynx)
• Key signaling pathways that regulate activity-dependent translation initiation in neurons (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus,prion)
• The current understanding of PELP1 signaling pathway (, Homo sapiens,Mus musculus,Xenopus laevis)
• Novel Therapies Against Aggressive and Recurrent Epithelial Cancers by Molecular Targeting Tumor- and Metastasis-Initiating Cells and Their Progenies (, NA)
• Molecular stratification and precision medicine in systemic sclerosis from genomic and proteomic data (, NA)
• Because KAT2B is a novel genetic susceptibility factor for drug abuse, we built a GeneMANIA () network centered around KAT2B to find related genes that may have functional links to drug abuse (, NA)
• Model illustrating the signaling pathways activated by optimal DA and hyperdopamine (, NA)
• BMP signal transduction (, NA)
• Mdm network and its regulation of p53 activities: a rheostat of cancer risk (, NA)
• Centrosomes are multifunctional regulators of genome stability (, NA)
• Interplay Between Centrosomes and the Hippo Tumor Suppressor Pathway (, NA)
• BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,NA)
• BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,NA)
• Galactose-1 phosphate uridylyltransferase (GalT) gene: a novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• Mixed Lineage Kinase-3 Inhibitor URMC-099 Improves Therapeutic Outcomes for Long-Acting Antiretroviral Therapy (, Oryctolagus cuniculus,Capra hircus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus,Derris trifoliata)
• Oncogenic Notch1 Signalling (, NA)
• Autoinflammatory disease regulated by IL-1B (inflammasomopathies) and NFKB (, NA)
• Proposed model of GF-mediated regulation of IGFBP-3 (, NA)
• Renin angiotensin system and the metabolic syndrome (, NA)
• Regulation of muscle protein synthesis (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Immune and central nervous systems interact and contribute to the etiology and pathophysiology of cytokine-induced depression (, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus,Mycobacterium tuberculosis variant bovis BCG)
• Simplified MAPK signaling pathway diagram depicting places where Mn has (demonstrated previously and in this study) an effect (, NA)
• Carnosol in human prostate cancer PC3 cell line (, Homo sapiens)
• Metabolism and the circadian clock converge (, Homo sapiens,Mus musculus)
• Epidermal growth factor receptor signaling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease (, NA)
• Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies (, NA)
• Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies (, NA)
• Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies (, NA)
• Signaling Pathway and Dysregulation of PD1 and its Ligands in Lymphoid Malignancies (, NA)
• Primary pathway through which class I PI3K activates mTORC1 (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Negative regulation of junctional stability in RPE by the PI3K–ROS circuit (, NA)
• Network mapping of genes with >5-fold expression change using IPA (, NA)
• Sonic hedgehog (SHH) pathway (, NA)
• Genes associated with autoimmunity regulate the CD40/NFKB signaling pathway (, Homo sapiens,Mus musculus)
• Primary Immunodeficiencies and Inflammatory Disease: A Growing Genetic Intersection (, Homo sapiens,Mus musculus,Lareunionomyces loeiensis,Groundnut rosette assistor virus)
• TGFB1 regulates collagen synthesis and accumulation to maintain homeostasis under physiological conditions (, Human immunodeficiency virus 1,Human immunodeficiency virus,Simian immunodeficiency virus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Nicotiana tabacum)
• Role of Erythrocyte-released ATP in the Regulation of Microvascular Oxygen Supply in Skeletal Muscle (, NA)
• Live cell imaging and systems biology (, NA)
• Role of Erythrocyte-released ATP in the Regulation of Microvascular Oxygen Supply in Skeletal Muscle (, NA)
• Connectivity of differentially expressed genes in the important signaling pathway following mixed PCBs exposure in human PBMC in vitro depicting the connectivity between genes expressed (with ≥1.5 fold change, t-test, p <0.05) (, NA)
• Redox-control of Matrix Metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease (, NA)
• JNK signaling pathway (, NA)
• FC-66 expression of the Ingenuity NFKB Signaling canonical pathway (, NA)
• Retinoid Pathway and Cancer Therapeutics (, Nicotiana tabacum,Zea mays,Triticum aestivum,Olea europaea,Daucus carota,Avena sativa,Bos taurus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Betapolyomavirus macacae,Homo sapiens,Xenopus laevis)
• 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NFKB and Important for Host Defense against Bacterial Pathogens (, NA)
• IL10/IL10R signaling pathway (, NA)
• Working model of an integrated axon degeneration signaling cascade (, NA)
• Bidirectional synaptic structural plasticity after chronic cocaine administration occurs through Rap1 small GTPase signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Salmonella enterica subsp. enterica serovar Typhimurium,Adeno-associated virus,Agaricus bisporus)
• Targeting RAS-mutant cancers: is ERK the key? (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis (, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Signal-transduction pathway of iloprost-stimulated vasodilation resulting from RBC-derived ATP release and endothelium-derived NO production (, NA)
• Functional network identified by genes in the single nucleotide polymorphism (SNP) component using independent component analysis (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Long noncoding RNAs in viral infections (, NA)
• Key components searched for in five investigated immune related pathways (, NA)
• The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system (, Homo sapiens,Mus musculus,Human papillomavirus,Clostridioides difficile)
• The RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system (, Homo sapiens,Mus musculus,Human papillomavirus,Clostridioides difficile)
• Pathways involved in internalization and sensing of dsDNA (, NA)
• CFTR Chloride Channel in the Apical Compartments: Spatiotemporal Coupling to its Interacting Partners (, NA)
• Canonical pathways for cardiovascular disease (, Homo sapiens,Mus musculus,clinical samples)
• Simplified representation of the extracellular signal-regulated kinases (ERK)1/2 branch of the mitogen-activated protein kinase (MAPK) signaling pathway and its interaction with xanthine oxidoreductase (XOR) and nitric oxide (NO) (, NA)
• Activation of the MEK – S6 pathway in high-grade ovarian cancers (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Unique genetic and epigenetic mechanisms driving signatures of paediatric diffuse high-grade glioma (, NA)
• Proposed model highlighting UPR (unfolded protein response) pathway with pro-apoptotic and anti-apoptotic protein signatures triggered by ER stress in alcohol treated monocyte derived dendritic cell (, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,Diaporthe sclerotioides)
• DNA Damage Response: Making it safe to play with knives (, NA)
• Programming anoikis induction (, NA)
• Biosynthetic pathway of mycolyl arabinogalactan (, NA)
• PI3K/AKT/mTOR pathway and cellular processes controlled by downstream signaling (, NA)
• Model summarizing the epigenetically regulated MLL2/FOXO/BRD4/c-Myc- axis in reducing the sensitivity of the HER2+ breast cancer cells to Lapatinib, and the synergy of Lapatinib and IBET in suppressing HER2+ breast cancer (, NA)
• Network of osteogenic specific proteins regulated by BMP2 signaling (, Mus musculus,Rattus norvegicus,Tobacco mosaic virus,Turnip yellow mosaic virus,Homo sapiens,Bos taurus,Nicotiana tabacum)
• Neurofibromatosis type 2 (, Homo sapiens,Mus musculus,Allium cepa)
• Sphingolipids in multiple sclerosis (, Mus musculus,Rattus norvegicus,Homo sapiens,Borreliella burgdorferi)
• Cellular FLICE-inhibitory protein: an attractive therapeutic target? (, NA)
• Cytokine-mediated cascade associated with chemotherapy-induced cognitive dysfunction (, NA)
• Regulation of enterohepatic circulation of bile acids by FXR (, NA)
• Disc in Flames: Roles of TNFA and IL-1B in Intervertebral Disc Degeneration (, NA)
• PI3K/AKT/mTOR signaling pathway and a proposed model for its regulation through the evaluated miRNAs (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Raphanus sativus)
• Deoxycholyltaurine-induced post-EGFR signaling in human colon cancer cells (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Dipturus trachyderma,Triportheus paranensis,Homo sapiens,Mus musculus,Armoracia rusticana,Human T-cell leukemia virus type I)
• Signaling pathway mobilized by GPIbA in response to botrocetin (bt)/ von Willebrand factor (VWF) treatment of suspension washed mouse platelets (, NA)
• Olfactory receptor (OR) signaling pathways (, NA)
• Wnt Signaling and Mammary Stem Cells (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Vitamin D and Calcium Regulation of Epidermal Wound Healing (, Homo sapiens,Mus musculus)
• Therapeutic interventions for fragile X syndrome (, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Agaricus bisporus,Homo sapiens,Drosophila melanogaster)
• Proposed mechanism by which activation of BDNF receptor TrkB using 7,8-dihydroxyflavone (7,8-DHF), a small-molecule TrkB agonist, improves brain plasticity and mental health following traumatic brain injury (TBI) (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus,Armoracia rusticana)
• Control of the HiNF-P/p220NPATpathway by p57KIP2 (, NA)
• PARP mechanism of action (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Double strand DNA repair: Homologous recombination and Non-homologous end joining (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• CGAS-STING Defense Pathway and Its Counteraction by Viruses (, NA)
• Toward an Orofacial Gene Regulatory Network (, Gallus gallus,Danio rerio,Xenopus laevis,Turdus migratorius,Homo sapiens,Mus musculus,Prunus persica)
• Neuropeptide Y (NPY) in tumor growth and progression: lessons learned from pediatric oncology (, NA)
• MicroRNA variants as genetic determinants of bone mass (, NA)
• Regulation of transcription by YAP/TAZ transcriptional co-factors and the regulation of YAP/TAZ activity in mammalian cells (, NA)
• Interconnections between the Hippo and RB/E2F pathways (, NA)
• Model demonstrating the specific apoptotic effect of SREBP-1 and FAS inhibition on GBM cells bearing EGFRvIII (, NA)
• Cytokines, hormones or growth factors that activate Stat5 (, NA)
• Signaling pathway alterations in Kupffer cells after alcohol and/or burn injury (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• p38 pathways regulate Ras oncogene activity by negative feedback (A) and signaling integration (B) (, NA)
• Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS (, NA)
• Characterization of the Human Pancreatic Islet Proteome by Two-Dimensional LC/MS/MS (, NA)
• Classical and non-canonical NFKB pathways (, NA)
• AIM2 inflammasome in infection, cancer and autoimmunity: role in DNA sensing, inflammation and innate immunity (, Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Streptococcus pneumoniae,Porphyromonas gingivalis,Mycobacterium tuberculosis variant bovis,Francisella tularensis,Legionella pneumophila,Brucella abortus,Francisella tularensis subsp. novicida,Chlamydia muridarum,Francisella tularensis subsp. tularensis,atypical mycobacterium,Hepatitis B virus,Human alphaherpesvirus 1,Human papillomavirus type 16,Vaccinia virus,West Nile virus,Murid betaherpesvirus 1,Chikungunya virus,Murid herpesvirus 68,Plasmodium falciparum,Plasmodium berghei,Homo sapiens,Mus musculus,prion,Aspergillus fumigatus)
• The mechanism of Wnt-mediated suppression of osteoclast differentiation (, NA)
• The molecular mechanisms of estrogen receptors (, NA)
• Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis (, NA)
• Oxidative Stress—Chronic Stress Cycle of Aging (, NA)
• MicroRNA-based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer (, NA)
• F-BOX proteins in cancer cachexia and muscle wasting: emerging regulators and therapeutic opportunities (, Saccharomyces cerevisiae,Curcuma longa,Camellia sinensis,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Transcriptional control of cardiac fibroblast plasticity (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network (, NA)
• Importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes (, Salmonella enterica subsp. enterica serovar Typhimurium,Lactococcus lactis,Bacteroides fragilis,Lacticaseibacillus casei,Akkermansia muciniphila,Coxsackievirus B3,Coxsackievirus B4,Kilham rat virus,Mus musculus,Rattus norvegicus,gut metagenome,Triticum aestivum,Hordeum vulgare,human gut metagenome,Homo sapiens,Schistosoma mansoni)
• Intracellular signaling pathway within cranial neural crest cells mediated by endothelin-1 (Edn1) (, NA)
• SUMO modification cycle (, NA)
• Ca2+ waves activate transcription factor NFAT that in turn controls cell cycle (, Homo sapiens,Mus musculus,Xenopus laevis,Vasconcellea candicans)
• TNF-dependent signalling pathways mediated through TNFR1 and TNFR2 (, NA)
• Critical growth factors and signalling pathways controlling human trophoblast invasion (, Homo sapiens,Mus musculus,Betapolyomavirus macacae)
• Programming and reprogramming neural cells by (endo-) cannabinoids: from physiological rules to emerging therapies (, Mus musculus,Rattus norvegicus,Castor fiber,Diaporthe sclerotioides,Cannabis sativa,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• Molecular mechanisms of ethanol-associated OESCC (, NA)
• Polyp to colorectal cancer sequences (, NA)
• Role of RKIP in various signaling pathways (, Homo sapiens,Bos taurus)
• Mosquito defense strategies against viral infection (, NA)
• INHIBITOR OF APOPTOSIS PROTEINS AS INTRACELLULAR SIGNALING INTERMEDIATES (, Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Wnt Signaling During Fracture Repair (, NA)
• Three mechanisms and related signaling that underlie Tat-mediated increases in Ca2+ influx/[Ca2+]in and hyper-excitation of mPFC pyramidal neurons (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Oryctolagus cuniculus)
• Proposed model (, NA)
• NSAIDs inhibit PGE2-induced tumorigenesis through targeting multiple downstream signaling pathways of PGE2 (, Mus musculus,Rattus norvegicus,Homo sapiens)
• SLIT/ROBO pathway: a regulator of cell function with implications for the reproductive system (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Ovis aries)
• Up-regulation of Paxillin and Focal Adhesion Signaling follows Dystroglycan Complex deletions and promotes a Hypertensive State of Differentiation (, Bos taurus,Canis lupus familiaris,Equus caballus,Mus musculus,Rattus norvegicus,Gallus gallus,Triportheus paranensis,Homo sapiens)
• Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer (, Homo sapiens,Rattus norvegicus)
• Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Sus scrofa,Heloderma suspectum)
• Mechanisms involved in alcohol-mediated suppression of type I IFN pathway in human hepatocytes (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Armoracia rusticana,Matthiola incana,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,NA)
• Complement-targeted therapeutics (, NA)
• Untapped Potential of Tyrosine-based G Protein Signaling (, Saccharomyces cerevisiae,Eucalyptus intertexta,Homo sapiens,Mus musculus)
• Calcium pathway machinery at fertilization in echinoderms (, NA)
• Stop signs in hippocampal insulin signaling: the role of insulin resistance in structural, functional and behavioral deficits (, NA)
• Mesenchymal and endodermal signaling events (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Eragrostis tef)
• Feedback Regulation of G Protein-Coupled Receptor Signaling by GRKs and Arrestins (, NA)
• DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States (, NA)
• A proposed model illustrating how SOX4 interacts with PI3K-AKT, Wnt-Beta-catenin, and AR signaling pathways, and how the PI3K-AKT-mTOR pathway regulates the expression of SOX4 in prostate cancer progression (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Helianthus annuus,Homo sapiens)
• Schematic model of signaling pathways implicated in tumor cell vascular mimicry (VM) (, NA)
• Identification of compounds that modulate retinol signaling using a cell-based qHTS assay (, NA)
• Transcriptional control of invariant NKT cell development (, NA)
• Rewiring Cells: Synthetic biology as a tool to interrogate the organizational principles of living systems (, NA)
• SYK tyrosine kinase: a crucial player in diverse biological functions (, NA)
• MicroRNA deregulation in cancer cells and the tumor microenvironment (, NA)
• NFKB Signaling Pathway: This model depicts the major components of the classical NFKB pathway (, NA)
• Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment (, Xenopus laevis,Calloplesiops altivelis,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• PAR Proteins: Fundamental Players in Animal Cell Polarization (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Oryctolagus cuniculus,Caenorhabditis elegans,Capra hircus,Homo sapiens,Nicotiana tabacum,Hyphomicrobium denitrificans)
• Fever and the thermal regulation of immunity: the immune system feels the heat (, Gallus gallus,Scombridae gen. sp.,Zootoca vivipara,Gnathostomata,Dipsosaurus dorsalis,Bos taurus,Canis lupus familiaris,Panthera tigris,Elephas maximus,unidentified influenza virus,Enterovirus C,Apis mellifera,Schistocerca gregaria,Rinderpest morbillivirus,Erpobdella obscura,Mus musculus,Rattus norvegicus,Escherichia coli,Aeromonas hydrophila,Homo sapiens,Phaseolus vulgaris)
• Fever and the thermal regulation of immunity: the immune system feels the heat (, Gallus gallus,Scombridae gen. sp.,Zootoca vivipara,Gnathostomata,Dipsosaurus dorsalis,Bos taurus,Canis lupus familiaris,Panthera tigris,Elephas maximus,unidentified influenza virus,Enterovirus C,Apis mellifera,Schistocerca gregaria,Rinderpest morbillivirus,Erpobdella obscura,Mus musculus,Rattus norvegicus,Escherichia coli,Aeromonas hydrophila,Homo sapiens,Phaseolus vulgaris)
• Schematic model recapitulating the role Shoc2 plays in controlling ERK1/2 activity (, NA)
• Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention (, Allium cepa,Raphanus sativus,Petroselinum crispum,Apium graveolens Dulce Group,Thymus vulgaris,Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Dipturus trachyderma)
• Divalent cation signaling in immune cells (, Saccharomyces cerevisiae,Candida albicans,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Human gammaherpesvirus 4)
• Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders (, Mus musculus,Rattus norvegicus,Cavia porcellus,Sus scrofa,Ovis aries,Homo sapiens,Drosophila melanogaster,Gallus gallus,Human immunodeficiency virus,Bikinia letestui)
• Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders (, Mus musculus,Rattus norvegicus,Cavia porcellus,Sus scrofa,Ovis aries,Homo sapiens,Drosophila melanogaster,Gallus gallus,Human immunodeficiency virus,Bikinia letestui)
• Integration of non-SMAD and SMAD signaling in TGFB1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Human papillomavirus type 16)
• Insulin signaling pathway (, NA)
• Longevity: Mapping the path to a longer life (, NA)
• VHL in clear-cell renal cell carcinoma and its relation to targeted therapy (, Homo sapiens,Mus musculus)
• Normal biology of the VHL-HIF axis in the setting of (A) normoxia and (B) hypoxia (, NA)
• Calcineurin–NFAT (nuclear factor of activated T-cells) pathway and its possible regulation by vasoactive intestinal peptide (VIP) (, NA)
• Non-canonical Wnt pathways (, NA)
• Canonical Wnt/Beta-catenin pathway (, NA)
• Emerging functions of amphiregulin in orchestrating immunity, inflammation and tissue repair (, Homo sapiens,Mus musculus,unidentified influenza virus,Trichuris muris)
• Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury (, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• Working model of IR activation in rod photoreceptor cells (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Bos taurus,Gallus gallus)
• Synaptic long term potentiation canonical pathway in adolescent rats treated with chronic nicotine (, NA)
• Major cellular mechanisms controlling contraction in gastrointestinal smooth muscle cells (, NA)
• New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease (, NA)
• New Strategies in Renal Cell Carcinoma: Targeting the Genetic and Metabolic Basis of Disease (, NA)
• Complement system (, Mus musculus,Homo sapiens)
• TRAF6 in T lymphocyte activation and differentiation (, Drosophila melanogaster,Toxoplasma gondii,Leishmania major,Human gammaherpesvirus 4,Listeria monocytogenes,Streptococcus pneumoniae,Vesicular stomatitis virus,Homo sapiens,Mus musculus)
• Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice (, NA)
• Iron homeostasis in host defence and inflammation (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Mycobacterium tuberculosis variant bovis BCG,Haemophilus influenzae,Neisseria meningitidis,Yersinia pestis,Yersinia enterocolitica,Vibrio vulnificus,Salmonella enterica subsp. enterica,Human immunodeficiency virus 1,unidentified influenza virus,Plasmodium falciparum,Leishmania donovani,Homo sapiens,Mus musculus,gut metagenome)
• Genes in one pathway have complex “net” interactions, which should be taken into consideration when analyzing proteomics/genomic data (, NA)
• Monogenic Mouse Models of Autism Spectrum Disorders: Common Mechanisms and Missing Links (, Homo sapiens,Mus musculus)
• Helicobacter pylori: gastric cancer and beyond (, NA)
• Emerging Treatment Mechanisms for Depression: Focus on Glutamate and Synaptic Plasticity (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Schematic diagram showing the interaction of the p75NTR and TrkB signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Vasconcellea candicans)
• Targeting DNA repair proteins for cancer treatment (, NA)
• Crosstalk between mAchR and VEGFR2 signaling (, Homo sapiens,Rattus norvegicus,Bos taurus)
• Contrasting Lifestyles Within the Host Cell (, NA)
• TNFR1-driven pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Murid betaherpesvirus 1)
• The many roles of FAS receptor signaling in the immune system (, NA)
• The many roles of FAS receptor signaling in the immune system (, NA)
• This figure shows the two distinct but ultimately converging apoptosis signaling pathways in mammals (, NA)
• Obesity-linked metabolic pathways susceptible to diet induced epigenetic perturbation (, NA)
• Lipid-induced Signaling Causes Release of Inflammatory Extracellular Vesicles from Hepatocytes (, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Targeting Notch signaling pathway to overcome drug-resistance for cancer therapy (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Complement and Periodontitis (, Staphylococcus aureus,Porphyromonas gingivalis,Streptococcus pyogenes,Aggregatibacter actinomycetemcomitans,Streptococcus sp. group B,Treponema denticola,Tannerella forsythia,Prevotella intermedia,Homo sapiens,Mus musculus)
• Complement and Periodontitis (, Staphylococcus aureus,Porphyromonas gingivalis,Streptococcus pyogenes,Aggregatibacter actinomycetemcomitans,Streptococcus sp. group B,Treponema denticola,Tannerella forsythia,Prevotella intermedia,Homo sapiens,Mus musculus)
• Multifaceted biology of plasmacytoid dendritic cells (, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Murid betaherpesvirus 1,Murine hepatitis virus,Homo sapiens,Macaca mulatta,Mus musculus,Caenorhabditis elegans,NA,NA,NA,NA)
• Proposed signaling pathway by which the mutant GPD1-L and NADH downregulate cardiac Na+ channel by causing PKC activation and ROS overproduction from the complex III of mitochondrial electron transport chain (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Genome-Wide Association Study of New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting Surgery (, NA)
• LIF/JAK/STAT3 signaling pathway in mouse ESC self-renewal (, NA)
• Canonical Wnt/Beta-catenin signaling pathway in mouse, rat and human ESC self-renewal (, NA)
• FGF signaling pathway in mouse, rat and human ESC self-renewal (, NA)
• Activin/Nodal signaling pathway in human ESC self-renewal (, NA)
• Highly heterogeneous, activated and short-lived regulatory T cells during chronic filarial infection (, NA)
• TNF biology, pathogenic mechanisms and emerging therapeutic strategies (, NA)
• Potential mechanisms by which SHP-1 regulates mast cell development and function (, NA)
• Diagrams of the Hippo signaling pathway in (A) Drosophila melanogaster and (B) mammals highlight the core kinase cascade and upstream regulatory signals (, NA)
• Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Hypothetical model for SWAP-70 function in mast cell FcERI signaling (, NA)
• ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Simplified scheme of the double-edged role of Akt in tumor development (, NA)
• Succinate and AKG accumulation and signaling via GPR91 and GPR99 in response to cell or mitochondrial stress (, NA)
• The components of the complex purinergic signaling pathways mediated by extracellular nucleotides (, NA)
• SELECTIVE INDUCTION OF CALCINEURIN ACTIVITY AND SIGNALING BY OLIGOMERIC AMYLOID BETA (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,prion)
• Long-term ERK Inhibition in KRAS-mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression (, NA)
• Molecular pathways of proliferation, survival and senescence (, Homo sapiens,Mus musculus)
• Role of axin in Wnt signaling in bone (, NA)
• Role of RGS proteins in selected GPCR signaling in bone (, NA)
• JS genes implicated in the Shh, Wnt, and PDGFA signaling pathway (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Danio rerio,Chlamydomonas reinhardtii)
• NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? (, NA)
• NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? (, NA)
• Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration (, NA)
• Rho Family GTPase signaling pathway alterations in adenoid cystic carcinoma (, Diaporthe sclerotioides,Sequoia sempervirens,Xanthorrhoea minor,Homo sapiens,Tragelaphus oryx,Xerophloea major)
• Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Escherichia coli,Calloplesiops altivelis)
• Growth factor signaling pathway (, NA)
• Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis (, NA)
• Schematic model of RIP1-mediated regulation of the PI3K-Akt pathway (, NA)
• Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease (, NA)
• Alteration of Notch signaling in skeletal development and disease (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Hh signaling pathway (, Bos taurus,Paraechinus aethiopicus,Notamacropus eugenii,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Andrena miranda,Homo sapiens,Danio rerio)
• Summary of the intracellular signaling cascades that occur within neurons and glia within the brain (, NA)
• Measured Motion: Searching for Simplicity in Spinal Locomotor Networks (, Danio rerio,Xenopus laevis,Myxine glutinosa,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Lower Succinyl-CoA:3-ketoacid-CoA Transferase (SCOT) and ATP Citrate Lyase In Pancreatic Islets of A Rat Model of Type 2 Diabetes: Knockdown of SCOT Inhibits Insulin Release In Rat Insulinoma Cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Regulation of Nlrp3 inflammasome by dietary metabolites (, Homo sapiens,Mus musculus,Candida dubliniensis,Citrobacter rodentium)
• CD47 regulation of autophagy (, NA)
• An integrated view of therapeutic strategies targeting the transcriptional network and signaling pathways promoting neuronal mitochondrial biogenesis (, NA)
• A-to-I editing of coding and non-coding RNAs by ADARs (, NA)
• Toll-like receptor (TLR) signaling pathways (, NA)
• Summary schematic illustrating the adaptations of select genes of the IGF-1/PI3K/Akt pathway involved in protein synthesis and degradation analyzed in the plantaris muscle (, NA)
• Pioneer Round of Translation: Features and Functions (, Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Schizosaccharomyces pombe,Human gammaherpesvirus 8)
• TLR and NLR pathways driving pro-inflammatory state after exposure to extracellular and Intracellular microbial products (, NA)
• Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy (, NA)
• Serpinin/pGlu-serpinin formation, its signaling pathway and PN-1-dependent biogenesis of secretory granules in (neuro)endocrine cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Ethanol signaling pathway that initiates neural crest apoptosis (, Mus musculus,Rattus norvegicus,Gallus gallus,Armoracia rusticana,Xenopus laevis,Lareunionomyces loeiensis,Homo sapiens,Drosophila melanogaster)
• Model PAS kinase activation and function in S (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli)
• Deletion of KvB1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Sequoia sempervirens)
• Metabolic pathway of P2Y12-receptor inhibitors (, Homo sapiens)
• Role for airway taste receptor modulation in the treatment of upper respiratory infections (, Staphylococcus aureus,Pseudomonas aeruginosa,Klebsiella pneumoniae,Staphylococcus epidermidis,Felis catus,Panthera leo,Tursiops truncatus,Mus musculus,Rattus norvegicus,Homo sapiens)
• O-GlcNAc Signaling: A Metabolic Link Between Diabetes and Cancer? (, Mus musculus,Rattus norvegicus,Xenopus laevis,Opsanus beta,Homo sapiens,Candida albicans)
• O-GlcNAc Signaling: A Metabolic Link Between Diabetes and Cancer? (, Mus musculus,Rattus norvegicus,Xenopus laevis,Opsanus beta,Homo sapiens,Candida albicans)
• Insulin, IGF-I and IGF-II signaling through the IGF-IR (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Luteolin and gefitinib regulation of EGF Signaling Pathway and Cell Cycle Pathway genes in PC-3 human prostate cancer cells (, NA)
• Complex roles of Wnts in cartilage homeostasis and disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Lareunionomyces loeiensis)
• Proposed model of IL-1 signaling in prostate (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Escherichia coli,Human papillomavirus type 16)
• Diagrams of relationships of selected proposed interactions between signaling pathways that influence proliferation and differentiation (, Caenorhabditis elegans,Homo sapiens)
• Computational Neuroscience: Modeling the Systems Biology of Synaptic Plasticity (, NA)
• NO-GAPDH-Siah1 cell death cascade in neurons (, NA)
• GAPDH nitrosylation pathway mediates cocaine effects (, NA)
• Insulin Signaling and Heart Failure (, NA)
• Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa (, Oryctolagus cuniculus,Sus scrofa,Sus scrofa domesticus,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,NA)
• Oxysterol-Related-Binding-Protein Related Protein-2 (ORP2) Regulates Cortisol Biosynthesis and Cholesterol Homeostasis (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Saccharomyces cerevisiae)
• Pathways involved in physiological and in pathological cardiac hypertrophy actuated in calcific aortic valve disease (CAVD) (, NA)
• Pediatric Gliomas as Neurodevelopmental Disorders (, NA)
• 3rd US-EU Workshop Systems level understanding of DNA damage responses (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster)
• Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Massachusetts Health Reform was Cost Saving for Individuals with New Venous Thromboembolism: A Cost-effectiveness Analysis (, Homo sapiens)
• The Molecular Basis of Craniofacial Placode Development (, Gallus gallus,Danio rerio,Xenopus laevis,Amniota,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Many oncogenic mutations drive nutrient transporter gene expression (, NA)
• Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling (, Gallus gallus,Danio rerio,Xenopus laevis,Petromyzon marinus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris,prion)
• Diabetes Medications: Impact on Inflammation and Wound Healing (, NA)
• Schematic depicting the Arg-auxotrophic response (, NA)
• Prostaglandin-mediated inhibition of PTH-stimulated Beta-catenin signaling in osteoblasts by bone marrow macrophages (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• G-protein–coupled receptor (GPCR) signaling in platelets (, NA)
• Mouse T cell development (, NA)
• Physiological bases of the K+ and the glutamate/GABA hypotheses of epilepsy (, NA)
• Phosphoproteome analysis links protein phosphorylation to cellular remodeling and metabolic adaptation during Magnaporthe oryzae appressorium development (, NA)
• Transforming growth factor beta (TGFB) family cell signaling pathway (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus,Ovis aries,Papio hamadryas)
• Core elements of the human EGFR–MAPK pathway (, Homo sapiens,NA)
• Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways (, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,murine stem cell retroviral vector)
• mTOR signaling in ALK+ ALCL oncogenesis (, Adenoviridae)
• Quantitative regulation by the TCF/Beta-catenin asymmetry pathway (, NA)
• Beyond the redox imbalance: oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Mechanical force induced AT1R activation and downstream effects (, Bos taurus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Canis lupus familiaris,Xenopus laevis,Homo sapiens,Mus musculus,Human papillomavirus type 6,Terfezia morenoi)
• Mutant epidermal growth factor receptor, EGFRvIII, promotes cell survival and proliferation by preferential signaling through the phosphotidyinositol-3-kinase (PI3K) pathway (, NA)
• The regulation of cell migration and invasion by PTHrP, involving activation of Rac1 (, NA)
• Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases (, NA)
• Schematic drawing of proposed underlying mechanisms of the bee venom (BV)-induced chemically relevant persistent nociception (CRPN) in the spinal cord dorsal horn (, Homo sapiens)
• Regain control of p53: targeting leukemia stem cells by isoform-specific HDAC inhibition (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Polyomavirus sp.)
• Signaling pathways involved in SSc pathogenesis that may also play a role in EndoMT (, Homo sapiens,Mus musculus,Antarctothoa delta)
• Involvement of the prohibitin (PHB/PHB1) in granulosa cell (GCs) survival and differentiation functions (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Equus caballus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Trypanosoma brucei,Mesocricetus auratus,Saccharomyces cerevisiae,Oryza sativa,Homo sapiens,Oncorhynchus mykiss)
• Neuroendocrine pathways regulate stress tolerance in C (, NA)
• Beyond Beta-catenin: prospects for a larger catenin network in the nucleus (, Xenopus laevis,Dipnomorpha,Homo sapiens,Mus musculus,Caenorhabditis elegans,Lareunionomyces loeiensis)
• Summary of the most important metabolic mechanisms proposed to occur in both cancer and Sertoli cells (SCs) (, Homo sapiens,Macaca mulatta,Papio hamadryas,Mus musculus,Rattus norvegicus,Bos taurus,NA)
• Diagram summarizing the PI3K/Akt/mTOR axis signaling pathway leading to the nucleation and formation of the phagophore to initiate the autophagy-lysosomal pathway (, NA)
• KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS (, NA)
• KEEPING AN EYE ON RETINOBLASTOMA CONTROL OF HUMAN EMBRYONIC STEM CELLS (, NA)
• P21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Pinus koraiensis,Homo sapiens,Antarctothoa delta)
• Hepcidin antagonists (, NA)
• Central Metabolism probed by hyperpolarized 13C enriched precursors (, NA)
• Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Phengaris arion)
• Network modeling of TGFB signaling in hepatocellular carcinoma epithelial-to-mesenchymal transition reveals joint Sonic hedgehog and Wnt pathway activation (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Phengaris arion)
• Gene interaction sub-network of shortest connections to common targets for the 36 candidate regulatory genes obtained by global literature analysis (Pathway Studio 7.0, Ariadne Genomics Inc., Rockville MD) (, NA)
• Calcium Signaling Pathway (KEGG, Kanehisa Laboratory in Kyoto University, Japan) with vinclozolin altered genes indicated (, NA)
• All for One and One for All on the Tick-Host Battlefield (, Ixodes scapularis,Ixodes ricinus,Homo sapiens)
• Adenosine monophosphate-activated protein kinase (AMPK) activators for the prevention, treatment and potential reversal of pathological pain (, Mus musculus,Rattus norvegicus,Homo sapiens)
• TOR signaling never gets old: Aging, longevity and TORC1 activity (, NA)
• TNF-R1 signaling pathways (, NA)
• Death receptor signaling and its interdigitation with the mitochondrial pathway of apoptosis (, NA)
• Estrogen and Estrogen Receptors on Cardiomyocytes: An Overview (, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Equus caballus,Homo sapiens)
• MicroRNA network that is involved in regulating myogenesis (, NA)
• Schematic of the drug- and cytokine-induced hepatocellular death signaling network, curated from literature references-, - (, NA)
• Advances and challenges in malaria vaccine development (, Plasmodium falciparum,Plasmodium berghei,Plasmodium vivax,Plasmodium yoelii,Plasmodium knowlesi,Plasmodium ovale,Plasmodium malariae,Human immunodeficiency virus 1,Human papillomavirus type 16,Human adenovirus 5,Modified Vaccinia Ankara virus,Human adenovirus 35,unclassified Simian adenoviruses,Homo sapiens,Pan troglodytes,Aotus nancymaae,Aotus griseimembra,Mus musculus,Rattus norvegicus,Escherichia coli,Diaporthe sclerotioides)
• Alternative pathway is constitutively active at low levels through the hydrolysis of the thioester in C3 to C3(H2O) (, Homo sapiens)
• Molecular Mechanisms of Pesticide-induced Neurotoxicity: Relevance to Parkinson’s Disease (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Macaca mulatta,Drosophila melanogaster)
• Heirarchical model of the PCP signaling pathway (, Gallus gallus,Xenopus laevis,Phoenicopterus roseus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Targeting Non-Homologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization (, Homo sapiens,Mus musculus)
• Histone GH2AX and Poly(ADP ribose) as Clinical Pharmacodynamic Biomarkers (, NA)
• Signaling pathways frequently deregulated in MDS (, NA)
• Poor tumor T cell infiltration (, NA)
• Scientific rationales of potential therapeutic combinations with PD pathway blockade (, NA)
• Classical and non-classical roles for pre-receptor control of DHT metabolism in prostate cancer progression (, Homo sapiens,Mus musculus)
• Phosphatidylinositol 3-Kinase: A Link Between Inflammation and Pancreatic Cancer (, NA)
• Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles (, NA)
• Phosphatase and Tensin Homologue deleted on Chromosome 10: Extending its PTENtacles (, NA)
• Viral hijacking of the host ubiquitin system to evade interferon responses (, Influenza A virus,Respiratory syncytial virus,Ebola virus,African swine fever virus,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Human T-cell leukemia virus type I,Measles morbillivirus,Sindbis virus,Human immunodeficiency virus 2,Human orthopneumovirus,Murine coronavirus,Murid gammaherpesvirus 4,Classical swine fever virus,Myxoma virus,Murid herpesvirus 68,Influenza B virus,Bovine viral diarrhea virus 1,Mason-Pfizer monkey virus,Woolly monkey sarcoma virus,Human adenovirus E4,Homo sapiens,Mus musculus,NA,NA,NA,NA)
• MicroRNA biogenesis pathways in cancer (, NA)
• Autophagy pathway (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Vasconcellea candicans,Homo sapiens,Bos taurus)
• Decorin induces autophagy in endothelial cells (, NA)
• Activation of PPARG and PTEN Cascade Participates in Lovastatin-mediated Accelerated Differentiation of Oligodendrocyte Progenitor Cells (, NA)
• Dopamine-sensitive signaling via adenylyl cyclase (AC), phospholipase C (PLC), and phosphatidylinositol-3-kinase (PI3K) systems (, NA)
• Phosphoinositide signaling cycle, showing the generation of second messengers and the resynthesis of phosphatidylinositide substrates (, NA)
• Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2) (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens)
• NFKB inducing kinase: a key regulator in the immune system and in cancer (, NA)
• Two major insulin signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Oreochromis mossambicus)
• Repair Pathway Choices and Consequences at the Double-Strand Break (, NA)
• Repair Pathway Choices and Consequences at the Double-Strand Break (, NA)
• Glucose stimulated insulin secretion (GSIS) and suggested stimulus/secretion coupling factors (, Mus musculus,Rattus norvegicus,Homo sapiens,Triportheus paranensis)
• Cardiovascular Complications Associated with VEGF Signaling Pathway Inhibition: Similarities to cardiovascular complications that can occur during pregnancy (, NA)
• An overview of different signaling pathways activated by high glucose ambience, which leads to an altered expression of various ECM glycoproteins, and of genes relevant to EMT and apoptosis processes (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Schematics depicting potential mechanism(s) by which high glucose induces ECM glycoprotein synthesis via the activation of small GTPases, Ras or Rho, in diabetic nephropathy (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Comparison of the known purinergic signaling pathways of animals to a hypothetical pathway in plants (, NA)
• Processes involved in generation of the T cell-inflamed tumor microenvironment phenotype (, Bifidobacterium longum,Bifidobacterium breve,Homo sapiens,Mus musculus,clinical samples)
• How tumor-intrinsic Beta-catenin signaling mediates exclusion of T cells from the tumor microenvironment (, Bifidobacterium longum,Bifidobacterium breve,Homo sapiens,Mus musculus,clinical samples)
• Endosomal System Genetics and Autism Spectrum Disorders: A Literature Review (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Sequoia sempervirens,Mycteroperca phenax,Uranoscopus scaber,Homo sapiens,Drosophila melanogaster)
• JAK/STAT signaling pathway (, NA)
• Schematics of the inside-out signaling of integrin activation (, NA)
• (Adapted from Alinari, Quinion, and Blum (, NA)
• Copper transport and regulation in Schizosaccharomyces pombe (, NA)
• Gq-dependent signalling by the lysophosphatidic acid receptor LPA3 in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA (, NA)
• ERAlpha-Negative and Triple Negative Breast Cancer: Molecular Features and Potential Therapeutic Approaches (, Homo sapiens)
• Reactive oxygen species, UV light or other genotoxic stresses, that induce DNA damage, principally, double-stranded breaks, is detected by the MRE11-RAD50-NBS1 complex, which in turn activates ATM (, NA)
• CD28 signaling pathway in T cells is equivalent to the IGF-1 pathway in the whole organism (, NA)
• Leptin, IGFBP3, and rapamycin suppress the IGF-1 signaling pathway to preserve naïve T cells and promote longevity (, NA)
• Sirtuins as regulators of metabolism and healthspan (, Saccharomyces cerevisiae,Arachis hypogaea,Homo sapiens,Mus musculus,Caenorhabditis elegans,Chenuda virus)
• Muscle Atrophy in Chronic Kidney Disease Results from Abnormalities in Insulin Signaling (, NA)
• Sirtuins as regulators of metabolism and healthspan (, Saccharomyces cerevisiae,Arachis hypogaea,Homo sapiens,Mus musculus,Caenorhabditis elegans,Chenuda virus)
• Sirtuins as regulators of metabolism and healthspan (, Saccharomyces cerevisiae,Arachis hypogaea,Homo sapiens,Mus musculus,Caenorhabditis elegans,Chenuda virus)
• IPA canonical pathway Cell Cycle: G1/S Checkpoint Regulation with up-regulated genes in the IR-induced common translatome highlighted in pink (, Diaporthe sclerotioides,Matthiola incana,Sequoia sempervirens,Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Dipturus trachyderma)
• “immune barrier hypothesis” posits that the chronic inflammation associated with CRS is linked to a defective mechanical and innate immune barrier (, NA)
• COLORECTAL CANCER (, Homo sapiens)
• Altogether, our findings are summarized in (, NA)
• Mechanobiology of TGFB Signaling in the Skeleton (, NA)
• Sex differences in the CRF1 receptor (, NA)
• Implications of gamma band activity in the pedunculopontine nucleus (, Mus musculus,Rattus norvegicus,Cavia porcellus,Allium tricoccum,Cordeauxia edulis,Homo sapiens)
• Genes in the MAP kinase signaling pathway (MAPK signaling pathway) identified using the KEGG-based pathway visualization tool (, NA)
• Rho Kinase-Dependent Sox9 Activation in Chondrocytes (, NA)
• Embryonic Morphogen, Nodal, is Associated with Channel-like Structures in Human Malignant Melanoma Xenografts (, NA)
• Lifecycle of cardiac Nav1.5 and potential phenotypic modifiers (, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Xenopus laevis)
• Schematic graph shows the potential roles of Akt/GSK-3B signaling in DA and NE modulation of synaptic functions in the PFC (, Mus musculus,Rattus norvegicus,Meriones unguiculatus,Homo sapiens,Macaca mulatta,Mustela putorius furo)
• Lysosomal–autophagy pathway (, Homo sapiens,Rattus norvegicus,Canis lupus familiaris)
• Hypothetical model for SUMO regulation in NFKB pathway (, NA)
• Peroxidation of Mitochondrial Membrane Phospholipids in Pancreatic Beta-Cell Failure (, NA)
• Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection (, Homo sapiens,Mus musculus)
• Defining the pathway to insulin-like growth factor system targeting in cancer (, Homo sapiens,Mus musculus,Escherichia coli,Betapolyomavirus macacae,Silybum marianum)
• Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (, NA)
• Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathogenesis of Nonalcoholic Steatohepatitis (, NA)
• Radiation induced activation of canonical and non-canonical hedgehog (Hh) signaling pathway (, Homo sapiens,Macaca mulatta,Macaca fascicularis,Mus musculus,Rattus norvegicus,Canis lupus familiaris,Hepatitis B virus)
• Implications of PC12 cell microarray/transcriptome analysis for pituitary adenylate cyclase-activating polypeptide (PACAP) actions, and PACAP-activated signaling pathways, in vivo (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Deletion of ERA in uterine epithelial cells leads to infertility, however, this receptor loss does not prevent estrogen induced epithelial cell proliferation () (, NA)
• MiR-155 on virulent (green) and avirulent (yellow) Mycobacterium species infection in macrophage (, NA)
• The mammalian target of rapamycin (mTOR) signaling pathway and crosstalk with the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K) pathway (, Homo sapiens,Mus musculus,Streptomyces hygroscopicus)
• Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis (, Oryctolagus cuniculus,Capra hircus,Felis catus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Hippocampus hippocampus)
• Direct and Indirect Roles of the LTBR Pathway in Central Tolerance Induction (, NA)
• Activin signaling regulates transcription of the FSHB gene (, Mus musculus,Rattus norvegicus,Sus scrofa,Ovis aries,Homo sapiens)
• SOX9 is downstream effector of ERG and AR in TMPRSS2:ERG fusion-positive PCa (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,clinical samples)
• Is There a Future for AKT Inhibitors in the Treatment of Cancer? (, Homo sapiens)
• Cell-cycle entry regulated by a network of protein regulators (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Hypothetical model of how Str1 may affect cellular behavior via the Beta-catenin/LEF signal transduction pathway (, Homo sapiens,Mus musculus)
• Model depicting a novel mechanism by which cetuximab induces autophagy (, NA)
• Antiviral Innate Immunity through the lens of Systems Biology (, NA)
• Targeting of signaling pathways by arsenic trioxide in chronic lymphocytic leukemia cells (, Homo sapiens)
• Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Effect of HDACI on cell survival signaling pathway in hemorrhagic shock (, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1)
• TLR4 signaling – a converged immune response pathway for hemorrhagic shock and septic shock (, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1)
• Signal transduction mechanisms involved in the mediation of cellular responses induced by secreted MIC-1 cytokine in certain cancer cells (, NA)
• Antioxidant enzyme schematic (, Mus musculus,Rattus norvegicus,Homo sapiens,Bikinia letestui)
• AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment (, NA)
• Pathways to cell death (, Rattus norvegicus,Homo sapiens)
• Nodes of therapeutic blockade in the PI3K and other signaling pathways that synergize with BET inhibition (, Homo sapiens)
• Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence (, Mus musculus,Rattus norvegicus,Vaccinia virus,Coxsackievirus B3,Homo sapiens,NA)
• Ever Expanding Role of HIF in Tumour and Stromal Biology (, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Ever Expanding Role of HIF in Tumour and Stromal Biology (, Homo sapiens,Mus musculus,Canis lupus familiaris)
• The ras signaling pathway (, NA)
• Signal transduction from G-protein-coupled receptors and integrins (, NA)
• Maladaptive striatal plasticity in L-DOPA-induced dyskinesia (, NA)
• Type III IFN signaling pathway (, Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Salmonella enterica,Enterococcus faecalis,Lactococcus lactis,Haemophilus influenzae,Borreliella burgdorferi,Staphylococcus epidermidis,atypical mycobacterium,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Respiratory syncytial virus,Murine norovirus,Homo sapiens,Mus musculus,NA)
• Biological function of extracellular HMGB1 is redox dependent (, NA)
• CSCs drug resistance methodology (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus)
• Molecular machinery of myelin gene transcription in Schwann cells (, Mus musculus,Rattus norvegicus,Homo sapiens)
• NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Xenopus laevis,NA)
• Schematic illustrating putative molecular pathways mediating the effects of centrally administered LPS on sympathetic drive (, Homo sapiens,Rattus norvegicus,Oryctolagus cuniculus,Shigella sonnei)
• EATING OURSELVES TO DEATH AND DESPAIR: THE CONTRIBUTION OF ADIPOSITY AND INFLAMMATION TO DEPRESSION (, Homo sapiens)
• Reciprocal antagonism by TLR4 oncogenic and TGFB tumor suppressor pathways (, Homo sapiens,Mus musculus,Helicobacter pylori,NA)
• Fas apoptotic pathway (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Citrus x paradisi,Streptomyces hygroscopicus)
• Glutathione metabolism pathway in the cytoplasm and in extracelluar space (, Nicotiana tabacum,Human immunodeficiency virus 1,Diaporthe sclerotioides,Hepatitis B virus,Human immunodeficiency virus,Cannabis sativa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Transcript abundance patterns in Kawasaki disease patients with IVIG resistance (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Epigenetic modulation of gene expression governs the brain’s response to injury (, NA)
• Genetic basis of kidney cancer: a metabolic disease (, Homo sapiens,Mus musculus)
• Genetic basis of kidney cancer: a metabolic disease (, Homo sapiens,Mus musculus)
• Genetic basis of kidney cancer: a metabolic disease (, Homo sapiens,Mus musculus)
• Interaction network of 135 SNO-modified proteins identified in WT and AD mouse brain tissues (, Homo sapiens,Mus musculus,Bos taurus)
• PP2A positively and negatively regulates the Wnt signaling pathway (, NA)
• PP2A negatively regulates the mTOR signaling pathway (, NA)
• Leptin upregulates VEGF in breast cancer via canonic and non-canonical signaling pathways and NFKB/HIF-1A activation (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Escherichia coli,Cricetus cricetus,Streptomyces plicatus,Homo sapiens,Armoracia rusticana)
• PP2A positively and negatively regulates the MAPK signaling pathway (, NA)
• Coinhibitory pathways in the B7-CD28 ligand-receptor family (, NA)
• Exercise-Driven Metabolic Pathways in Healthy Cartilage (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Homeostatic Regulation of the PI(4,5)P2-Ca2+ Signaling System at ER-PM Junctions (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster)
• Nutrient-sensing mTORC1: integration of metabolic and autophagic signals (, NA)
• Identification of Primary Gene Targets of TFAP2C in Hormone Responsive Breast Carcinoma Cells (, NA)
• Mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Canis lupus familiaris)
• Lung cancer in women: role of estrogens (, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Relationship of P.gingivalis Infection and AtherosclerosisAs the bacterial load of P.gingivalis in the oral cavity increases periodontal disease becomes more severe (, Mycobacterium tuberculosis,Bacillus subtilis,Porphyromonas gingivalis,Aggregatibacter actinomycetemcomitans,Treponema denticola,Prevotella intermedia,Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• Complete vs (, Homo sapiens,Mus musculus,Danio rerio,Canis lupus familiaris,NA)
• Alternate metabolic programs define regional variation of relevant biological features in renal cell carcinoma progression (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,clinical samples)
• MTOR in maintenance of glomerular epithelial cells (, NA)
• Irinotecan pharmacogenomics (, NA)
• Reconstructed antioxidant regulation pathway of detoxifying proteins (, NA)
• Exosomes in liver pathology (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Hepatitis B virus,NA)
• “The Expanding GRK Interactome: Implications in Cardiovascular Disease and Potential for Therapeutic Development” (, NA)
• Converging roles of caspases in inflammasome activation, cell death and innate immunity (, NA)
• Converging roles of caspases in inflammasome activation, cell death and innate immunity (, NA)
• Major TGFB signaling pathways in vascular cells (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Gallus gallus,Bovine viral diarrhea virus 2)
• Enhanced Autophagy reveals vulnerability of P-gp mediated Epirubicin Resistance in Triple Negative Breast Cancer Cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Natural products as TLR agonists and antagonists affecting various stages in the signaling pathway, including downstream molecules MyD88 and IKK (, NA)
• IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance (, Homo sapiens,Mus musculus)
• Quercetin potentiates UVB-induced c-Fos expression: Implications for its use as a chemopreventive agent (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Panax ginseng,Dipturus trachyderma,NA)
• Major Apoptotic pathways (, NA)
• Complement - a key system for immune surveillance and homeostasis (, Escherichia coli,Staphylococcus aureus,Listeria monocytogenes,Porphyromonas gingivalis,Streptococcus pyogenes,Bacillus anthracis,unidentified influenza virus,Measles morbillivirus,Homo sapiens,Mus musculus,Leishmania major,NA)
• Quantification of Beta-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry (, NA)
• Comprehensive Review of Pacritinib in Myelofibrosis (, NA)
• Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing, and disease (, NA)
• The pathway of EGF induced anticipatory UPR activation (, NA)
• Genes represented in the 38-gene DTC panel and their biological pathway associations (, Homo sapiens,clinical samples)
• The TGFB signaling pathway and how a dominant negative TGFB type II receptor lacks the cytoplasmic domain necessary for TGFB signaling (, NA)
• Searching for the Chokehold of NRAS Mutant Melanoma (, NA)
• Actionable drugs in proliferation pathway that have been evaluated in BRAFmut CRC (, Homo sapiens,Mus musculus)
• TLR and NLR signaling (, NA)
• GnRH receptor (GnRHR) signaling within the pituitary gonadotrope that leads to LH biosynthesis (, Homo sapiens,Mus musculus)
• PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (, NA)
• Diverse extracellular signaling pathways are regulated by A disintegrin and metalloproteinase (ADAM)-mediated shedding events (, Staphylococcus aureus,Helicobacter pylori,Listeria monocytogenes,Bacteroides fragilis,Lacticaseibacillus rhamnosus GG,Plasmid pTF1,Homo sapiens,Mus musculus)
• Putative model for the intracellular signaling pathways involved in NPY-induced VSMC proliferation (, NA)
• Role and mechanism of action of complement in regulating T cell immunity (, NA)
• Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective (, NA)
• Molecular Pathways: Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma (, NA)
• Immune Response (, NA)
• Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy (, NA)
• Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease (, NA)
• Divergent behavior of mucosal memory T cells (, NA)
• Activation of the Beta2-AR with isoproterenol increases cAMP which then activates PKA (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• TNFA Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Diaporthe sclerotioides)
• Emerging role of coagulation proteases in kidney disease (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Streptomyces griseus,Streptomyces microflavus,Homo sapiens,Limulus polyphemus)
• CD73: A novel target for cancer immunotherapy (, Homo sapiens,Mus musculus)
• New model for phrenic LTF with multiple molecular pathways (, NA)
• Molecular mechanisms of short-term depression in the hypoxic ventilatory response (, NA)
• Hypothetical model for transcriptional regulation of Tspo in hormone- and cAMP- responsive MA-10 Leydig cells, and non-responsive NIH/3T3 fibroblasts (, Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Homo sapiens,Ginkgo biloba)
• TLR AGONISTS: Are They Good Adjuvants? (, Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Mycobacterium tuberculosis variant bovis BCG,Porphyromonas gingivalis,Streptococcus pyogenes,Bacillus anthracis,Mycobacterium tuberculosis variant bovis,Staphylococcus epidermidis,Serratia marcescens,Leptospira interrogans,Salmonella enterica subsp. enterica serovar Minnesota,Mycobacterium tuberculosis variant bovis BCG str. Glaxo,Human immunodeficiency virus 1,Human papillomavirus,unidentified influenza virus,Mouse mammary tumor virus,Vaccinia virus,H5N1 subtype,Murid betaherpesvirus 1,Human papillomavirus types,Modified Vaccinia Ankara virus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Camptotheca acuminata,Drosophila melanogaster,Patella vulgata,Homo sapiens,Mus musculus,NA)
• Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein (, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Regulation of Energy Metabolism and the IGF-1/mTOR Pathways by the p53 Protein (, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Dopamine D2 Receptor Signaling Modulates Mutant Ataxin-1 S776 Phosphorylation and Aggregation (, NA)
• Molecular mechanisms of the HVD (, NA)
• Molecular Diagnosis and Therapy of Kidney Cancer (, NA)
• PIK3/Akt/mTOR Pathway (, NA)
• Aortic valve stenosis–related biological processes (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Cord Blood Genomic Analysis Highlights the Role of Redox Balance (, Homo sapiens,Cinchona pubescens)
• Eph receptors and ephrins in cancer: bidirectional signaling and beyond (, NA)
• Eph receptors and ephrins in cancer: bidirectional signaling and beyond (, NA)
• Role of chaperone-mediated autophagy in metabolism (, NA)
• Mammalian target of rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction (, NA)
• Modulating immune function and controlling inflammation (, NA)
• Elevated integrin A6B4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer (, NA)
• Proposed steps in the PIK (A) and TMC (B) polyketide biosynthetic pathway (, NA)
• Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries,NA)
• Viral tricks to grid-lock the type I interferon system (, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,West Nile virus,Ebola virus,Enterovirus C,Measles morbillivirus,Japanese encephalitis virus,Foot-and-mouth disease virus,Human orthopneumovirus,ssRNA viruses,SARS coronavirus NS-1,Rift Valley fever virus,Hepatovirus A,Classical swine fever virus,Tick-borne encephalitis virus,Influenza B virus,Bovine viral diarrhea virus 1,Zaire ebolavirus,Mengo virus,Tick-borne flavivirus,New world arenaviruses,Anopheles B virus,Homo sapiens,Mus musculus,Matthiola incana,NA,NA,NA,NA,NA)
• Regulation of hepcidin production (, Homo sapiens)
• Adipose tissue dysfunction and its effects on tumor metabolism (, NA)
• Targeting lipid metabolism for the treatment of Anaplastic Thyroid Carcinoma (, Homo sapiens,Mus musculus,Candida dubliniensis)
• Diversity in Post-Transcriptional Control of Neutrophil Chemoattractant Cytokine Gene Expression (, NA)
• Cystic Kidney Disease: the Role of Wnt Signaling (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Fanconi Anemia Proteins and Endogenous Stresses (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Human papillomavirus type 16)
• STAT3 signaling pathway (, NA)
• PD-1 Pathway in Tolerance and Autoimmunity (, NA)
• PD-1 Pathway in Tolerance and Autoimmunity (, NA)
• PD-1 Pathway in Tolerance and Autoimmunity (, NA)
• Systematic Analysis of Essential Genes Reveals New Regulators of G protein Signaling (, NA)
• Vascular endothelial growth factor (VEGF) binds to the VEGF receptor, a receptor tyrosine kinase, leading to receptor dimerization and subsequent auto phosphorylation of the receptor complex (, NA)
• Oncogenic survival signaling components in PCNSL (, NA)
• Comings and goings of MHC class I molecules herald a new dawn in cross-presentation (, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli 27A,Escherichia coli O6H16CFAII str. B2C,Vesicular stomatitis virus,Vaccinia virus,Homo sapiens,Mus musculus,Drosophila melanogaster,Iris germanica,NA)
• Wnt signaling (, NA)
• Antagonizing integrin beta3 increases immune suppression in cancer (, NA)
• Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A (, NA)
• Epigenome-wide DNA Methylation Analysis Implicates Neuronal and Inflammatory Signaling Pathways in Adult Murine Hepatic Tumorigenesis following Perinatal Exposure to Bisphenol A (, NA)
• Probing the complexities of astrocyte calcium signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,adeno-associated virus 2,Notolabrus celidotus)
• Histological chorioamnionitis shapes the neonatal transcriptomic immune response (, Homo sapiens,Macaca mulatta,Mus musculus)
• Targeting the Pentose Phosphate Pathway in Syndrome X-related Cardiovascular Complications (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• HER2 signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,Triportheus paranensis,Corynebacterium phage gamma)
• Regulation of biomechanical signals by NFKB transcription factors in chondrocytes (, NA)
• M2a polarization (, Mus musculus,Rattus norvegicus,Homo sapiens,Trypanosoma cruzi,Staphylococcus aureus Chi-4)
• Hypothetical representation of regulation of calcium ion [Ca2+]i homeostasis by PKD-related proteins and summary of potential novel therapeutic interventions targeting major downstream effects of mutations disrupting this pathway (, NA)
• Osteogenic Transcription Factor Runx2 Regulates Components of the Fibroblast Growth Factor/Proteoglycan Signaling Axis in Osteoblasts (, NA)
• Schematic presentation of mechanisms of actions of CTS (, NA)
• Biomechanical Signals Suppress TAK1 Activation to Inhibit NFKB Transcriptional Activation in Fibrochondrocytes (, Rattus norvegicus,Homo sapiens)
• Tumor Microenvironment in Non-Small Cell Lung Cancer (, NA)
• Canonical signal transduction cascades in preclinical models of despair and major depressive disorder (, NA)
• Molecular and Genetic Inflammation Networks in Major Human Diseases (, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human papillomavirus,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Human papillomavirus type 16,H1N1 subtype,Adeno-associated virus,West Nile virus,H5N1 subtype,Human alphaherpesvirus 2,Human alphaherpesvirus 3,Simian immunodeficiency virus,Polyomavirus sp.,Human betaherpesvirus 6,Human betaherpesvirus 7,Staphylococcus aureus,Mycobacterium tuberculosis,Clostridioides difficile,Clostridioides difficile CD3,Francisella tularensis subsp. novicida,Clostridioides difficile CD8,Clostridioides difficile CD44,Clostridioides difficile CD160,Homo sapiens,Macaca mulatta,Pan troglodytes,Chlorocebus aethiops,Cercocebus atys,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,gut metagenome,human metagenome,Danio rerio,prion,NA)
• Toll-like Receptors, Triggering Receptor Expressed on Myeloid Cells Family Members and Receptor for Advanced Glycation End-products in Allergic Airway Inflammation (, Mus musculus,Rattus norvegicus,Escherichia coli,Pseudomonas aeruginosa,Respiratory syncytial virus,Human rhinovirus sp.,Homo sapiens,Aspergillus fumigatus,Dermatophagoides farinae)
• Wnt/Beta-catenin signalling (, NA)
• T-cell activation is regulated by antigen presentation, as well as stimulatory and inhibitory co-receptors (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis (, Mus musculus,Rattus norvegicus,Oryza sativa,Lablab purpureus,Homo sapiens,Gallus gallus,Rous sarcoma virus)
• Differentiating mTOR Inhibitors in Renal Cell Carcinoma (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Looking beyond structure: membrane phospholipids of skeletal muscle mitochondria (, Mus musculus,Rattus norvegicus,Triportheus paranensis,Oncorhynchus mykiss,Salmo trutta,Heterocephalus glaber,Sus scrofa,Tachyglossus aculeatus,Homo sapiens)
• Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European-American women (, NA)
• RAS-mediated signal transduction pathways and post-translational modification of RAS (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Rat sarcoma virus)
• Effect of estrogen on the mechanisms of VSM contraction (, Homo sapiens,Equus caballus)
• Effect of estrogen on endothelium-dependent pathways of vascular relaxation (, Homo sapiens,Equus caballus)
• ER-activated postreceptor mechanisms (, Homo sapiens,Equus caballus)
• Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway (, NA)
• p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression (, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Phenotypic pathway of hepatic stellate cells (HSCs).Hepatocyte damage causes an inflammatory reaction which leads to activation of hepatic stellate cells (HSCs) (, Mus musculus,Rattus norvegicus,Homo sapiens)
• IFN-induced Guanylate Binding Proteins in Inflammasome Activation and Host Defense (, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Vibrio cholerae,Bacillus anthracis,Shigella flexneri,Citrobacter rodentium,Francisella tularensis subsp. novicida,Moraxella bovis,Chlamydia muridarum,Burkholderia thailandensis,Candida dubliniensis,PX clade,Homo sapiens,Mus musculus,Danio rerio,Human alphaherpesvirus 1,prion,Toxoplasma gondii,NA)
• Mechanism of polyphenols' antioxidant properties (, NA)
• Curcumin and PKC signaling pathway in colon cancer (, NA)
• Proposed signaling pathways and outcomes after stroke and administration of wt tPA or tPA-A.296-299 wt-tPA drives pathway toward the right leading to damage whereas tPA-A296-299 drives pathway towards the left and providing protection (, NA)
• Metabolomics in rheumatic diseases: desperately seeking biomarkers (, NA)
• Translation control of gene expression (, NA)
• CAMP/PKA signaling pathway critically regulates molecular components underlying long-term potentiation and long-term memory (, NA)
• Estrogen pathway and cervical carcinogenesis (, Human papillomavirus,Human papillomavirus type 16,Human papillomavirus types,human papillomavirus 18,Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus)
• Mediator complex: a central integrator of transcription (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Danio rerio,Human immunodeficiency virus 1)
• Mitochondrial Impairment Caused by Mutant Huntingtin (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Canis lupus familiaris)
• The PI3K/PDK1/AGC signaling pathway underlying the different mechanism of AKT and other AGC substrates activation by PDK1 (, Homo sapiens,Mus musculus)
• G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery (, NA)
• Fgf regulates dedifferentiation during skeletal muscle regeneration in adult zebrafish (, NA)
• ACTIVATION OF p53 IN DOWN SYNDROME AND IN THE Ts65Dn MOUSE BRAIN IS ASSOCIATED WITH A PRO-APOPTOTIC PHENOTYPE (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Control of 5′ UTR transcript translation depends on mTOR signaling (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Treponema medium)
• Major cellular events of GPCR signaling and trafficking (, NA)
• `G protein-dependent' signal control from intracellular membranes (, NA)
• Actions of IL-21 on T cells are context-dependent and shaped by cellular and environmental parameters (, NA)
• Microarray and bioinformatics analysis of tendon fibroblasts treated with PRP or PPP (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Understanding Extranuclear (Nongenomic) Androgen Signaling: What a frog oocyte can tell us about human biology (, NA)
• From HLA-B27 to spondyloarthritis: a journey through the ER (, Mus musculus,Rattus norvegicus,Human gammaherpesvirus 4,Middle East respiratory syndrome-related coronavirus,Homo sapiens,Diaporthe sclerotioides)
• Currently available therapies targeting EGFR signaling pathway (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Diaporthe sclerotioides)
• Genetic and environmental association between parental monitoring and risk of cannabis, stimulants, and cocaine initiation in a sample of male twins: Does parenting matter? (, NA)
• Arginine Vasopressin Receptor Signaling and Functional Outcomes in Heart Failure (, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Sus scrofa,Cavia porcellus,Homo sapiens,Gallus gallus)
• BRCA1 and BRCA2: different roles in a common pathway of genome protection (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Zea mays,Ustilago maydis,Homo sapiens,Caenorhabditis elegans)
• Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Just So Stories about the Evolution of Apoptosis (, Elephas maximus,Panthera pardus,Panthera onca,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Rickettsia prowazekii)
• Complement in disease: a defence system turning offensive (, NA)
• HCV dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy (, NA)
• PTEN-regulated signaling pathway (, NA)
• gp130-dependent cytokines promote axon regeneration and SOCS3 act as a critical negative regulator of the signaling pathway (, NA)
• Activation of “RNA-sensing” TLRs on neurons and microglia triggers distinct effects (, NA)
• Roles of the PtdIns(3,4,5)P3/Akt pathway on insulin signaling in liver fat and muscle tissue with representative substrates indicated (, NA)
• GAG subversion (, Human immunodeficiency virus 1,Human alphaherpesvirus 1,Human papillomavirus,Dengue virus,Respiratory syncytial virus,Human papillomavirus type 16,Human alphaherpesvirus 2,Ebola virus sp.,Human coronavirus NL63,Human orthopneumovirus,SARS coronavirus NS-1,Merkel cell polyomavirus,Human metapneumovirus,Hepatitis delta virus,Hop mosaic virus,Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Listeria monocytogenes,Vibrio cholerae,Streptococcus pyogenes,Borreliella burgdorferi,Chlamydia trachomatis,Neisseria gonorrhoeae,Streptococcus sp. group A,Yersinia enterocolitica,Escherichia coli RS218,Plasmodium falciparum,Plasmodium vivax,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Gigaspora candida,NA,NA,NA)
• Arsenic signaling (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Saccharomyces cerevisiae,Escherichia coli,Vasconcellea candicans,Escherichia coli 53A,Homo sapiens,H1N1 subtype)
• Immunopathogenesis and Therapeutic Approaches in Pediatric Celiac Disease (, NA)
• “Go upstream, young man”: lessons learned from the p38 saga (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• CAR targeted miRNA and mRNA in liver cancer (, NA)
• Xenobiotic Receptor Activation: Direct vs. Indirect (, NA)
• Selected IGF-axis genes that encode core components of IGF-axis upstream the PI3K/AKT/mTOR and RAS/MAPK/ERK pathway (, Homo sapiens,Mus musculus)
• Model deciphering the signalling pathway hijacked by EspT leading to induction of inflammatory responses in macrophages (, NA)
• Cellular Functions of Transient Receptor Potential channels (, Homo sapiens,Drosophila melanogaster)
• Integration of Endothelial Protease-activated Receptor-1 Inflammatory Signaling by Ubiquitin (, NA)
• Role of GSK3B in skin tumorigenesis (, NA)
• Signaling pathways of TLR4 (, NA)
• GLP-1 acts by means of the GLP-1-R to stimulate adenylyl cyclase (AC), and thereby cAMP production, and to activate the cAMP-binding proteins PKA and Epac (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic presentation of the molecular and blood pressure responses elicited by peripheral NMDAR activation (, NA)
• Hox Genes and Regional Patterning of the Vertebrate Body Plan (, NA)
• O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Mouse mammary tumor virus)
• Intracellular and intercellular signaling and cellular dynamics in bone healing and bone remodeling (, Human papillomavirus,Human papillomavirus type 16,Ebola virus,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Mycobacterium tuberculosis,gut metagenome)
• Intracellular Trafficking of Bacterial Toxins (, Escherichia coli,Vibrio cholerae,Bacillus anthracis,Homo sapiens,Mus musculus,Ovis aries)
• Diversity of insect antiviral immunity: insights from viruses (, Dengue virus,Vaccinia virus,West Nile virus,Sindbis virus,Chikungunya virus,Dengue virus type 2,Flock House virus,Drosophila C virus,Cricket paralysis virus,Invertebrate iridescent virus 6,Drosophila X virus,Autographa californica multiple nucleopolyhedrovirus,Deformed wing virus,Culex Y virus,unidentified entomopoxvirus,Spodoptera littoralis nucleopolyhedrovirus,Spodoptera frugiperda ascovirus 1a,Drosophila melanogaster,Bombyx mori,Apis mellifera,Aedes aegypti,Anopheles gambiae,Varroa destructor,Drosophila immigrans,Homo sapiens)
• Innate Immune Evasion Strategies of DNA and RNA viruses (, Dengue virus,West Nile virus,Coxsackievirus B3,Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Measles morbillivirus,Enterovirus A71,Murine hepatitis virus,Porcine reproductive and respiratory syndrome virus,Ebola virus sp.,Yellow fever virus,Human immunodeficiency virus 2,ssRNA viruses,SARS coronavirus NS-1,Alphapapillomavirus 7,enterovirus D68,Molluscum contagiosum virus,Homo sapiens,NA,NA,NA,NA)
• Intracellular signaling pathways of EET’s (, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Capsicum frutescens,Homo sapiens,Bos taurus)
• Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer (, NA)
• Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer (, NA)
• Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer (, NA)
• IL-33 signaling pathway (, Mus musculus,Rattus norvegicus,Influenza A virus,Respiratory syncytial virus,Homo sapiens,Canis lupus familiaris,Dermatophagoides farinae)
• Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment (, NA)
• Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Normal and Cancer-Related Functions of the p160 Steroid Receptor Coactivator (SRC) Family (, Homo sapiens,Mus musculus)
• Resistance to RAF inhibitors (, Homo sapiens)
• Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy (, NA)
• Free fatty acids (FFAs) induce hepatocyte apoptosis (, NA)
• Immune mediators of chronic pelvic pain syndrome (, NA)
• Genomic Landscape of Male Breast Cancers (, Homo sapiens)
• Axotomy activates the Wallerian degeneration pathway for the selective elimination and degeneration of severed axons (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Bacterial Protein Acetylation: the Dawning of a New Age (, Escherichia coli,Bacillus subtilis,Salmonella enterica,Saccharomyces cerevisiae,Prorocentrum lima,Homo sapiens,Mus musculus)
• SGK1 Activity is Modulated by Resistin in Vascular Smooth Muscle Cells and in the Aorta in Response to Diet-Induced Obesity (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• The three top ranked pathways in this study.‘Syndecan-1-mediated signaling events’ from PID; (B) ‘Signaling of hepatocyte growth factor (c-Met)’ from BioCarta; (C) ‘Growth hormone signaling pathways’ from BioCarta (, Mus musculus,Rattus norvegicus,Homo sapiens,Venustaconcha ellipsiformis)
• Working model of adenosine mediated intracellular signaling in corpus cavernosum (, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• 5-Oxo-ETE and the OXE receptor (, NA)
• Molecular Biology of Renal Cell Cancer and Its Association with the Hypoxia Pathway (, Homo sapiens)
• Novel targets for the treatment and palliation of gastrointestinal neuroendocrine tumors (, NA)
• Schematic diagram demonstrates intracellular signaling events in the Ras/ERK1/2 pathway as well as the upstream and downstream cascades activated by GDNF in the C18-4 cells (, Mus musculus,Homo sapiens)
• Alternative signaling by B2-ARs (, Homo sapiens,Mus musculus)
• Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Citrobacter rodentium,NA)
• Involvement of the Notch signaling pathway during endocrine cell differentiation (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Simplified Overview of TLR Signaling (, Aspergillus fumigatus,Fusarium solani,Ambrosia artemisiifolia,Staphylococcus aureus,Pseudomonas aeruginosa,Homo sapiens,Mus musculus,Human alphaherpesvirus 1)
• Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Citrobacter rodentium,NA)
• Emerging Roles for Non-canonical NFKB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Citrobacter rodentium,NA)
• Pathways involved in physiological and in the pathological cardiac hypertrophy of calcific aortic valve disease (CAVD) (, NA)
• Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies (, NA)
• Schematic diagram depicting the molecular mechanisms by which inflammation activates hepcidin transcription in the liver (, Danio rerio,Turdus migratorius,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Borreliella burgdorferi)
• Schematic diagram depicting the proposed role of bone morphogenetic protein (BMP) signaling pathway, HJV, HFE, and TFR2 in iron sensing and hepcidin regulation in the liver (, Danio rerio,Turdus migratorius,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Borreliella burgdorferi)
• Glial cell line-derived neurotrophic factor can signal through a Ras-induced pathway in SSCs (, NA)
• Glial cell line-derived neurotrophic factor can signal through activation of Src kinases in SSCs (, NA)
• Schematic model of regulatory pathways involved in Mycn stabilization (, NA)
• Rodent models for compulsive alcohol intake (, NA)
• Hepcidin Regulation in the Anemia of Inflammation (, NA)
• Hepcidin Regulation in the Anemia of Inflammation (, NA)
• Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Immune cell-derived complement on T cell immune responses (, Homo sapiens,Mus musculus)
• Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development (, NA)
• Co-ordinating Notch, BMP, and TGFB Signalling During Heart Valve Development (, NA)
• Redox signaling: an evolution from free radicals to aging (, NA)
• Chloride Regulation in the Pain Pathway (, NA)
• Signaling network that regulates ISC activity in response to injury (, NA)
• GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE STIMULATES THE PROLIFERATION OF COLORECTAL CANCER CELLS (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Sus scrofa,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Endocytosis of Nanomedicines (, Mus musculus,Rattus norvegicus,Betapolyomavirus macacae,Lyssavirus rabies,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Venustaconcha ellipsiformis)
• Potential functions of intracellular peptides (, NA)
• Slippery Signaling: Palmitoylation-dependent Control of Neuronal Kinase Localization and Activity (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Agaricus bisporus,Brassica napus subsp. rapifera,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Teaching old receptors new tricks: biasing seven-transmembrane receptors (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Meleagris gallopavo,Tobacco etch virus)
• Multiple levels of regulation control stress-induced differentiation in Toxoplasma (, Toxoplasma gondii,Homo sapiens)
• A Synopsis of Factors Regulating Beta Cell Development and Beta Cell Mass (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Solanum lycopersicum,Plasmid pTF1)
• Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis (, NA)
• Metabolic pathways and genes involved in the utilization of nonfermentable carbons (, NA)
• Oridonin regulates multi-signaling pathways to display corresponding multifunctional effects (, herbal medicine,Isodon rubescens,Isodon japonicus,Semiaquilegia adoxoides,Isodon trichocarpus,Isodon sculponeatus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Empowering Regulatory T Cells in Autoimmunity (, Homo sapiens,Mus musculus,NA)
• STING: infection, inflammation and cancer (, NA)
• Interaction between the canonical WNT signaling pathway and other signaling pathways implicated in MPNST tumorigenesis (, NA)
• mTOR signal pathway (, NA)
• The Akt/mTORC1 signaling pathway leading to accelerated translation and increased protein synthesis (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Taxol biosynthetic pathway (, NA)
• Model illustrating the involvement of CBP/p300 function as a cointegrator of different signaling (, NA)
• PD and PK pathways of HMGCo A reductase inhibitors (Statins) (, NA)
• Schematic representing intrinsic and extrinsic apoptosis initiation (, NA)
• Proposed DAP12 signaling pathway in macrophages and osteoclasts (, NA)
• CHOP-induced apoptosis under prolonged ER stress (, NA)
• Molecular pathway for arterial, venous and lymphatic cell fate determination in vertebrate embryo (, NA)
• Schematic signal transduction network representing the effect of chronic alcohol on protein balance in eWAT (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Zea mays,Simian endogenous retrovirus)
• Avoidance and subversion of eukaryotic homeostatic autophagy mechanisms by bacterial pathogens (, Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Agrobacterium tumefaciens,Francisella tularensis,Brucella abortus,Yersinia enterocolitica,Francisella tularensis subsp. novicida,Coxiella burnetii,Anaplasma phagocytophilum,Brucella melitensis,Brucella suis,Francisella tularensis subsp. tularensis,Francisella tularensis subsp. holarctica,Francisella philomiragia,Francisella noatunensis,Legionella sp. A,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Capra hircus)
• NF-kB signaling pathways (, NA)
• Molecular mechanisms of innate immune inhibition by non-segmented negative-sense RNA viruses (, NA)
• The (A) Wnt/Beta-catenin, (B) AKT/mTOR, (C) ERK/MAPK signaling networks that are important for oligodendrocyte development and myelination (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Lareunionomyces loeiensis)
• Hedgehog signaling pathway (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Paraechinus aethiopicus,Meriones unguiculatus,Homo sapiens,Drosophila melanogaster,Danio rerio,Helicobacter pylori)
• Eicosanoids and cancer (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus,Gallus gallus)
• Eicosanoids and cancer (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus,Gallus gallus)
• Eicosanoids and cancer (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus,Gallus gallus)
• The proposed crosstalk between PC1 and calcineurin/NFAT signalling in hPDL cells under mechanical stimulation (, NA)
• Regulation of Lipid and Glucose Metabolism by Phosphatidylcholine Transfer Protein (, NA)
• Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Citrus macrophylla,Iris germanica,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Citrus macrophylla,Iris germanica,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• Striking the Target in Wnt-y Conditions: Intervening in Wnt Signaling During Cancer Progression (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Citrus macrophylla,Iris germanica,Homo sapiens,Drosophila melanogaster,Mouse mammary tumor virus)
• Induction of Type I Interferons by Bacteria (, Escherichia coli,Mycobacterium tuberculosis,Helicobacter pylori,Listeria monocytogenes,Streptococcus pneumoniae,Vibrio cholerae,Borreliella burgdorferi,Francisella tularensis,Legionella pneumophila,Brucella abortus,Yersinia pestis,Streptococcus sp. group B,Yersinia pseudotuberculosis,Chlamydia muridarum,Mycobacterium tuberculosis HN878,Homo sapiens,Mus musculus,Human betaherpesvirus 5)
• Targeting the MAPK Pathway in Melanoma: Why some approaches succeed and other fail (, NA)
• Hypoxia-inducible transcription factor (HIF) pathway in clear cell renal cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans)
• Recent advances in the genetics of systemic lupus erythematosus (, Mus musculus,Homo sapiens)
• Molecular pathways underlying the development of the male external genitalia (, Canis lupus familiaris,Equus caballus,Paraechinus aethiopicus,Metatheria,Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Mouse mammary tumor virus,unidentified)
• Steroidogenic pathway (, Canis lupus familiaris,Equus caballus,Paraechinus aethiopicus,Metatheria,Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Mouse mammary tumor virus,unidentified)
• Roles of MAS-related G protein coupled receptor-X2 (MRGPRX2) on mast cell-mediated host defense, pseudoallergic drug reactions and chronic inflammatory diseases (, NA)
• Factors involved in the ontogeny of fetal Leydig cells (, NA)
• Molecularly and temporally separable lineages comprise the hindbrain roof plate and contribute differentially to the choroid plexus (, NA)
• Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Danio rerio,Diaporthe sclerotioides,NA)
• Critical role of the sphingolipid pathway in stroke: a review of current utility and potential therapeutic targets (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Danio rerio,Diaporthe sclerotioides,NA)
• Hedgehog signal transduction: key players, oncogenic drivers, and cancer therapy (, NA)
• Diagram showing some key features of AQP2 recycling (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Gallus gallus,Armoracia rusticana)
• Toll-like receptors in kidney disease (, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Streptococcus pneumoniae,Pseudomonas aeruginosa BL10,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA)
• Complement-mediated regulation of metabolism and basic cellular processes (, NA)
• Proposed model for macrophage inhibitory cytokine-1 (MIC-1)-mediated signaling events that promote actin cytoskeleton rearrangement (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Bellapiscis medius)
• MOLECULAR PATHWAYS: JAK/STAT PATHWAY: MUTATIONS, INHIBITORS, AND RESISTANCE (, NA)
• Anesthesia-related Carbon Monoxide Exposure: Toxicity and Potential Therapy (, Nicotiana tabacum,Citrus aurantiifolia,Ligusticum porteri,Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Sus scrofa,Papio hamadryas)
• DISTINCT SPECTRUM OF COPY NUMBER ABERRATIONS IN PAEDIATRIC HIGH GRADE GLIOMAS (, NA)
• Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression (, Homo sapiens,Sus scrofa,Ureaplasma parvum,NA)
• Glomerular basement membrane heparan sulfate in health and disease: a regulator of local complement activation (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Triportheus paranensis)
• JNK pathway activation modulates acquired resistance to EGFR/HER2 targeted therapies (, NA)
• Listeria monocytogenes and the inflammasome: from cytosolic bacteriolysis to tumor immunotherapy (, Listeria monocytogenes,Homo sapiens)
• Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target (, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Yersinia pseudotuberculosis,Brucella suis,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Respiratory syncytial virus,Adeno-associated virus,Betapolyomavirus macacae,Polyomavirus sp.,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Siproeta stelenes,Homo sapiens,Saccharomyces cerevisiae,Bos taurus)
• IMMUNOSUPPRESSIVE STRATEGIES THAT ARE MEDIATED BY TUMOR CELLS (, NA)
• The nicotinic-alpha7nAChR mediated activation of Jak2 neuroprotective pathway (, NA)
• Endocytosis and signalling: intertwining molecular networks (, Mus musculus,Rattus norvegicus,Danio rerio,Cyprinus carpio,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Convergent signaling pathways where inflammation and metabolic signaling intersect along the CHIEF pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Non-overlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi (, NA)
• Mitochondrial pathway of apoptosis (, NA)
• HGF signaling pathways; A) Representative structures, cMET binding affinities (KD) and dimerization of HGF, NK1 (cMET agonists) and NK2 (cMET antagonists (, NA)
• An integrative analysis of the InR/PI3K/Akt network identifies the dynamic response to Insulin signaling (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Matthiola incana,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Lineage relationships of cells originating in the otocyst (, Mus musculus,Rattus norvegicus,Cavia porcellus,Danio rerio,Phoenicopterus roseus,Homo sapiens,Drosophila melanogaster,Paraechinus aethiopicus)
• Dll4-Notch Signaling in Macrophage Activation (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,clinical samples)
• Ras signaling through RASSF proteins (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Human gammaherpesvirus 4)
• Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration (, Saccharomyces cerevisiae,Dictyostelium discoideum,Dictyostelium discoideum AX2,Guibourtia demeusei,Homo sapiens)
• Proposed mechanisms by which the interaction of dietary long-chain n-3 polyunsaturated fatty acids from fish oil and butyrate from bacterial fermentation of dietary fiber may reduce colon tumorigenesis (, Nicotiana tabacum,Glycine max,Malus domestica,Olea europaea,Curcuma longa,Theobroma cacao,Mus musculus,Rattus norvegicus,Gallus gallus,Triportheus paranensis,Homo sapiens)
• Schematic overview of costimulatory receptors and their ligands (, NA)
• Anticipatory UPR Activation: A Protective Pathway and Target in Cancer (, NA)
• Interplays between various posttranslational modifications (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Respiratory syncytial virus,Human T-cell leukemia virus type I,Measles morbillivirus,Murid gammaherpesvirus 4,Mycobacterium tuberculosis,Helicobacter pylori,Streptococcus pneumoniae,Haemophilus influenzae,Mycobacterium leprae,Mus musculus,Rattus norvegicus,Homo sapiens,Candida albicans)
• Sweet path to metabolic demise: fructose and lipid synthesis (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Saccharomyces cerevisiae,Zea mays,Homo sapiens,Canis lupus familiaris,Xenopus laevis,NA)
• Chemical Tumor Biology of Heparan Sulfate Proteoglycans (, NA)
• Mitochondria and Cancer (, Mus musculus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,Adenoviridae,NA)
• Host responses to Candida albicans: Th17 cells and mucosal candidiasis (, NA)
• Cellular pathways leading to upregulation of COX-2 in neutrophils (, Homo sapiens,Mus musculus)
• Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Agaricus bisporus,Homo sapiens)
• Crosstalks between EPCR, PAR-1, S1P1, and Tie2 (, Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Lymphangiogenesis and Lymphatic Metastasis in Breast Cancer (, Homo sapiens)
• General overview of BDNF and GDNF signaling mechanisms (, Mus musculus,Rattus norvegicus,Adeno-associated virus,Betapolyomavirus macacae,Homo sapiens,Oryctolagus cuniculus)
• Proposed mechanism of the priming phase of complement-induced liver regeneration (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Endotoxin binding: Schematic overview of the LPS, LBP, CD14 and TLR-4 signal transduction pathway (, NA)
• Roles of cGMP and S-nitrosylation in NO-based signaling (A) and enzymatic protein denitrosylation mediated by the S-nitrosoglutathione reductase (GSNOR) and thioredoxin (Trx) systems (B) (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Homo sapiens,Human gammaherpesvirus 4)
• Possible interactions between cholinergic and eCB signaling in the toxicity of organophosphorus anticholinesterases (, Mus musculus,Rattus norvegicus,Cavia porcellus,Arachis hypogaea,Musa acuminata,Cannabis sativa,Homo sapiens,Canis lupus familiaris)
• TGFB ligands signal through the type I and type II TGFB receptors (, Homo sapiens,Mus musculus,Human papillomavirus type 16)
• Deep mRNA Sequencing for In Vivo Functional Analysis of Cardiac Transcriptional Regulators: Application to GAq (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Four pathways for double-stranded break (DSB) repair.Nascent DSBs are first recognized by ATM and the MRN complex that initiate a series of DNA damage response events that aim at arresting cell cycle and recruiting DSB repair proteins (, NA)
• Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer (, NA)
• Adenosine-A1 Receptor Agonist Induced Hyperalgesic Priming Type II (, Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens,Capsicum frutescens)
• Neuregulin 1 - erbB4 pathway in schizophrenia: From genes to an interactome (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Differential vulnerability of neurons in Huntington's disease: The role of cell type-specific features (, Homo sapiens,Mus musculus,Rattus norvegicus,Papio hamadryas,Drosophila melanogaster,Prevotella sp.)
• Islet GPCRs and their downstream signaling pathways (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Eurotium medium)
• Multiple Faces of FGF-23 (, NA)
• Possible orientation of nuclear Beta-AR signaling complexes (, NA)
• Stem cell metabolism (, NA)
• Transport proteins in Alzheimer’s disease (, NA)
• Protein components of the pheromone response network constructed by the PCST approach (, NA)
• Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization (, Homo sapiens)
• P53 stabilization (, Homo sapiens)
• Response of p53 to DSBs generated by ionizing radiation (, Homo sapiens)
• Targeting Hedgehog - a Cancer Stem Cell Pathway (, Bos taurus,Capra hircus,Ovis aries,Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Drosophila melanogaster)
• PKCD in neurotoxin-induced neuronal apoptosis (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,vectors)
• Drug-induced DNA damage may be repaired by various DNA repair pathways, or apoptosis may be triggered as a result of attempted repair of platinum-induced damage by the Mismatch Repair pathway (, NA)
• PPAR signaling pathway upregulated in LCMUFA group compared to control (FDR < 0.01) and olive oil group (FDR < 0.01) (, NA)
• Cellular apoptosis pathways and intervention by both cellular anti-apoptotic proteins and viral proteins encoded by oncolytic Ad, HSV and VV (, NA)
• Genetic Alterations in Glioblastoma Occur Frequently in 3 Cellular Signaling Pathways (, NA)
• Simplified scheme of signaling pathways required for maintenance of pluripotency of mESC (top panel) and hESC (bottom panel) (, NA)
• Endocrine related Hippo Signaling Pathway (, NA)
• Analysis and metabolic engineering of lipid-linked oligosaccharides in glycosylation-deficient CHO cells (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Saccharomyces cerevisiae)
• Role of AMP-activated Protein Kinase A1 in 17Alpha-Ethinylestradiol-induced Cholestasis in Rats (, NA)
• Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,Mycobacterium tuberculosis)
• New Strategies in Head and Neck Cancer: epidermal growth factor receptor inhibition in head and neck cancer (, Homo sapiens,Rattus norvegicus,Nicotiana tabacum,Human papillomavirus)
• Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes (, Homo sapiens)
• Signalling through growth factor receptors can activate the PI3K/Akt/mTOR pathway and the JAK3/STAT5 pathway (, Mus musculus,Homo sapiens)
• Bruton’s tyrosine kinase in autoimmunity and implications for therapy (, NA)
• Cell-free Xenopus egg extracts for studying DNA damage response pathways (, Xenopus laevis,Xenopus tropicalis,Homo sapiens,Saccharomyces cerevisiae,Betapolyomavirus macacae,Lambdavirus lambda)
• Planar cell polarity (PCP) proteins and spermatogenesis (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Xenopus laevis,Phoenicopterus roseus,Homo sapiens)
• Scheme of the glycogen synthase kinase-3 (GSK3) signaling pathway modulated by ketamine (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of ROS in TNFA induced endothelial dysfunction (, NA)
• Neurobiology of dysregulated motivational systems in drug addiction (, NA)
• Carbohydrate metabolism and fermentation in tumor cells (, Escherichia coli,Mycobacterium tuberculosis,Lactococcus lactis,Archaeoglobus fulgidus,Lysinibacillus sphaericus,Pseudarthrobacter oxydans,Saccharomyces cerevisiae,Candida albicans,Raphanus sativus,Cydonia oblonga,Bos taurus,Drosophila melanogaster,Equus caballus,Schistosoma japonicum,Homo sapiens,Mus musculus)
• Pheochromocytoma: The First Metabolic Endocrine Cancer (, NA)
• Lactic acid bacteria differentially regulate filamentation in two heritable cell types of the human fungal pathogen Candida albicans (, NA)
• SIRT1-dependent Regulation of Chromatin and Transcription: Linking NAD+ Metabolism and Signaling to the Control of Cellular Functions (, NA)
• MYELOID HSF1-Beta-CATENIN AXIS REGULATES NLRP3 INFLAMMASOME ACTIVATION IN MOUSE LIVER ISCHEMIA/REPERFUSION INJURY (, NA)
• Fast-Acting Antidepressants Rapidly Stimulate ERK Signaling and BDNF Release in Primary Neuronal Cultures (, NA)
• Schematical overview of the signaling pathway mediated by OA1 (, NA)
• Schematical overview of the signaling pathway mediated by MC1R (, NA)
• WNT1-Inducible Signaling Pathway Protein-1 Activates Diverse Cell Survival Pathways and Blocks Doxorubicin-induced Cardiomyocyte Death (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Mouse mammary tumor virus,Vasconcellea candicans)
• With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Schizosaccharomyces pombe,Homo sapiens,Streptomyces hygroscopicus,Tor tor)
• With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Schizosaccharomyces pombe,Homo sapiens,Streptomyces hygroscopicus,Tor tor)
• Calcineurin signaling and PGC-1A expression are suppressed during muscle atrophy due to diabetes (, NA)
• Diagram of PDGF-D cross-talks with other pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Paracentrotus lividus)
• More to life than NFKB in TNFR1 signaling (, NA)
• Current Understanding of Metformin Effect on the Control of Hyperglycemia in Diabetes (, NA)
• IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction (, Listeria monocytogenes,Yersinia enterocolitica,Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Cryptosporidium parvum)
• IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction (, Listeria monocytogenes,Yersinia enterocolitica,Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Cryptosporidium parvum)
• GRK isoforms regulating the signaling of the dopamine receptors in the striatum (, Mus musculus,Rattus norvegicus,Homo sapiens,Merluccius merluccius)
• Physiological mechanisms and therapeutic potential of bone mechanosensing (, NA)
• Ingenuity pathway analysis of endocrine networks depicted in through (, NA)
• Oxidative stress intracellular signaling pathways in lung cancer (, Mus musculus,Rattus norvegicus,Triticum aestivum,Sambucus nigra,Homo sapiens,clinical samples)
• Genetics of immune-mediated disorders (, NA)
• Illustration showing how the CaMKII–MK2 pathway may exacerbate hyperglycaemia and hyperinsulinaemia in obesity (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Candida dubliniensis)
• Microenvironmental Regulation of Hematopoietic Stem Cells and Its Implications in Leukemogenesis (, NA)
• Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways (, NA)
• MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage (, Homo sapiens,Mus musculus,vectors,Calloplesiops altivelis)
• Tuberous Sclerosis Complex: A Brave New World? (, Homo sapiens,Mus musculus,Pluchea carolinensis)
• IGF-I activation of a signaling pathway to mTOR (, Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Saccharomyces cerevisiae,Drosophila melanogaster,Canis lupus familiaris,Adeno-associated virus,Streptomyces hygroscopicus)
• DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HIPPOCAMPUS PROTEOME AND METABOLOME PROFILES IN ADULT OFFSPRING (, NA)
• Melatonin receptor signaling (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Meriones unguiculatus,Oryctolagus cuniculus,Tupaia glis,Homo sapiens,Danio rerio)
• Emerging role of alternative splicing of CRF1 receptor in CRF signaling (, Cricetulus griseus,Cricetus cricetus,Oryctolagus cuniculus,Homo sapiens)
• Possible mechanism of regulation of SIRT1 and AMPK pathway by CD38 inhibition (, Drosophila melanogaster,Caenorhabditis elegans,Toxoplasma gondii,Paracentrotus lividus,Aplysia californica,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Streptococcus sp. group A)
• Signaling through the PI-3 Kinase-Akt pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus)
• Transcriptional regulation by E2F complexes modulates cell-cycle control, cell fate, and survival (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Does Activation of the Blood Coagulation Cascade Play a Role in Malaria Pathogenesis? (, NA)
• (1) Nicotine binds to the nicotinic acetylcholine receptor, causing a conformational change that opens the receptor's ion channel and allowing entry of Ca2+ and Na+ (, NA)
• Energy Metabolism and Inflammation in Brain Aging and Alzheimer’s Disease (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,Caenorhabditis elegans,Xenopus laevis,Candida dubliniensis)
• Displayed is the signaling pathway associated with insulin-mediated activation of endothelial nitric oxide synthase (eNOS) (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Corynephage beta)
• Disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5) (, Micropterus salmoides,Homo sapiens)
• Models for organization of CO2signaling pathways (, NA)
• DEVELOPMENTAL CIGARETTE SMOKE EXPOSURE II: HEPATIC PROTEOME PROFILES IN 6 MONTH OLD ADULT OFFSPRING (, NA)
• Simplified representation of oncogenic signaling cascades in pancreatic cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa,Alburnus alburnus)
• Complement cascade (, Homo sapiens)
• Pathway analysis using all altered genes and proteins (, Escherichia coli,Escherichia coli 27A,Escherichia coli KD2,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Simplified diagram of mTORC1 and ERK1/2 signaling following muscle contraction (, Mus musculus,Rattus norvegicus,Homo sapiens)
• The Activin/TGFB mediated Smad2/3 signaling pathway (, Mus musculus,Rattus norvegicus,Cavia porcellus,Mus musculus domesticus,Mus musculus castaneus,Mus musculus molossinus,Mus musculus musculus,Danio rerio,Xenopus laevis,Eublepharis macularius,Homo sapiens,Papio anubis,Drosophila melanogaster,Agaricus bisporus,Monkeypox virus)
• Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling (, Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Drosophila melanogaster,Candida dubliniensis)
• Injury site-specific targeting of complement inhibitors for treating stroke (, NA)
• IGF-1R Signaling (, Homo sapiens,Macaca mulatta,Callithrix jacchus,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Glires,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue (, Oryctolagus cuniculus,Equus asinus,Homo sapiens,Mus musculus)
• Merkel Cell Polyomavirus Infection and Merkel Cell Carcinoma (, Polyomavirus sp.,Merkel cell polyomavirus,Homo sapiens)
• Neuronal ischemic preconditioning (, Homo sapiens,Flakea papillata)
• Osmotic stress and ABA sensing and signaling (, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Embryophyta,Physcomitrium patens,Homo sapiens)
• An Immunological Perspective on Neonatal Sepsis (, Homo sapiens,Mus musculus)
• DRAStic RHOAdblock of Pyrin inflammasome activation (, Homo sapiens,Mus musculus)
• Histiocytic Neoplasms in the Era of Personalized Genomic Medicine (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Double-strand break can be repaired by cNHEJ with minimal end processing (, Saccharomyces cerevisiae,Arabidopsis thaliana,PX clade,Chlamydomonas reinhardtii,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Dipturus trachyderma,Homo sapiens,Mus musculus,Bos taurus,Escherichia coli,Escherichia phage T7)
• Signaling in podocyte apoptosis (, NA)
• RA pathway (, NA)
• Non-invasive metabolic imaging of brain tumors in the era of precision medicine (, NA)
• Revitalization of a diastemal bud (, NA)
• Non-invasive metabolic imaging of brain tumors in the era of precision medicine (, NA)
• Results of a Pathway Studio® analysis of direct relationships between the components of the protein-bound fraction of renal cyst fluid (, NA)
• PI3K signaling: a molecular pathway associated with acute hypophagic response during inflammatory challenges (, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome)
• Epithelial and Live Epithelial Cell Extrusion (, NA)
• Illustration of different mechanisms of MUC1 and MUC4 for the repression of apoptosis (, NA)
• Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease (, Homo sapiens,Mus musculus)
• Environmental enrichment regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) (, NA)
• Cocaine regulation of specific Canonical Pathways at the mRNA level (left) and protein level (right) (, NA)
• Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis (, NA)
• Immunologic Consequences of Hypoxia during Critical Illness (, NA)
• The PI3K/mTOR signaling pathway (, Homo sapiens)
• (Pro)renin (PRR) Induces Renal Damage Via cyclooxygenase-2 (COX-2) signaling (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens)
• Two models for coupling the circadian clock to the cell cycle/checkpoint response (, Homo sapiens,Mus musculus,Eutheria)
• DNA damage checkpoint pathways (, Homo sapiens,Mus musculus,Eutheria)
• Cross-regulation of signaling pathways: an example of nuclear hormone receptors and the canonical Wnt pathway (, NA)
• Sphingosine Kinase: Role in Regulation of Bioactive Sphingolipid Mediators in Inflammation (, NA)
• Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures (, Homo sapiens,Saccharomyces cerevisiae)
• Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures (, Homo sapiens,Saccharomyces cerevisiae)
• NF1 is a direct G protein effector essential for opioid signaling to Ras in the striatum (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Heterotrimeric G Proteins: Breaking the rules of engagement, space and time (, NA)
• TLR8 couples SOCS-1 and restrains TLR7-mediated antiviral immunity exacerbating West Nile virus infection in mice (, NA)
• Two-signal model for NLRP3 inflammasome activation (, NA)
• Activation for non-canonical and alternative NLRP3 inflammasomes (, NA)
• Role of Interleukin-18 in the Pathophysiology of Allergic Diseases (, NA)
• Redox Biology and the Interface Between Bioenergetics, Autophagy and Circadian Control of Metabolism (, NA)
• The involvement of HSPs and class Ib molecules in immune surveillance and anti-tumor responses (, NA)
• Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells (, Mus musculus,Rattus norvegicus,Adeno-associated virus,adeno-associated virus 2,Homo sapiens)
• T cells in Systemic Lupus Erythematosus (, Homo sapiens,Mus musculus)
• Sphingolipids in Mitochondria (, NA)
• Immune signaling cascades triggered by Cryptococcus neoformans recognition (, NA)
• Endocytic Pathway in Microglia During Health, Aging and Alzheimer’s Disease (, Mus musculus,Cricetulus griseus,Homo sapiens,Candida dubliniensis,prion,Corynephage beta)
• Anabolic and catabolic pathways regulating skeletal muscle mass (, NA)
• Endocytic Pathway in Microglia During Health, Aging and Alzheimer’s Disease (, Mus musculus,Cricetulus griseus,Homo sapiens,Candida dubliniensis,prion,Corynephage beta)
• ER and SR interactions within mammalian cells (, NA)
• Disorders of the mTORC1 signaling pathway (, NA)
• Molecular mechanisms underlying alcohol-drinking behaviours (, NA)
• Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases (, NA)
• Ingenuity Pathway Analysis of the top overlapping networks in chronic beryllium disease and sarcoidosis (, NA)
• Intracellular cholesterol landscape: dynamic integrator of the immune response (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,Human immunodeficiency virus,unidentified influenza virus,Human papillomavirus type 16,West Nile virus,Human rhinovirus sp.,Human rotavirus,Homo sapiens,Mus musculus,NA,NA)
• PPARD mediated gene regulation (, NA)
• Alterations in DLPFC layer 3 pyramidal cells in schizophrenia (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Diabetic cardiomyopathy: signaling defects and therapeutic approaches (, Homo sapiens)
• TNF axis in cancer progression and metastasis (, NA)
• New Insights into Protein Hydroxylation and Its Important Role in Human Diseases (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• PI3K Pathway in B Cell Metabolism (, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• PI3K Pathway in B Cell Metabolism (, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• PI3K Pathway in B Cell Metabolism (, Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• Revealing insect herbivory-induced phenolamide metabolism: from single genes to metabolic network plasticity analysis (, NA)
• Targeting cancer metabolism: dietary and pharmacological interventions (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Targeting cancer metabolism: dietary and pharmacological interventions (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta)
• Targeting Inflammation in Cancer Prevention and Therapy (, Hepatitis B virus,Human immunodeficiency virus,Human papillomavirus,Human T-cell leukemia virus type I,Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Homo sapiens,Helicobacter pylori,human gut metagenome,NA)
• Targeting Inflammation in Cancer Prevention and Therapy (, Hepatitis B virus,Human immunodeficiency virus,Human papillomavirus,Human T-cell leukemia virus type I,Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Homo sapiens,Helicobacter pylori,human gut metagenome,NA)
• Canonical Notch signaling and Notch conservation between human and Monosiga brevicollis (, Monosiga brevicollis,Homo sapiens)
• An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 (, Human immunodeficiency virus 1,Variola virus,Molluscum contagiosum virus,Variola minor virus,Drosophila melanogaster,Nicotiana tabacum,Erythroxylum coca,Pieris rapae,Homo sapiens,Mus musculus,Canis lupus familiaris,Staphylococcus aureus)
• An Update on the Genetics of Atopic Dermatitis: Scratching the Surface in 2009 (, Human immunodeficiency virus 1,Variola virus,Molluscum contagiosum virus,Variola minor virus,Drosophila melanogaster,Nicotiana tabacum,Erythroxylum coca,Pieris rapae,Homo sapiens,Mus musculus,Canis lupus familiaris,Staphylococcus aureus)
• Interleukin-10 (IL-10) gene transcription regulation (, NA)
• NLRP3, NLRC5, NLRP7, AIM2 and other inflammasome-like signaling is activated in response to S (, Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Neisseria meningitidis,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Candida dubliniensis,NA)
• Intrinsic pathway is deregulated in cancer (, Caenorhabditis elegans,Venustaconcha ellipsiformis,Homo sapiens,Mus musculus)
• Displays canonical IL-1 signaling pathway identified through Ingenuity Pathway Analysis (IPA) (, Chlamydia trachomatis,Neisseria gonorrhoeae,Mycoplasmoides genitalium,Sequoia sempervirens,Prunus persica,Homo sapiens,Mus musculus,unidentified,NA)
• Displays canonical P2Y Purinergic Receptor Signaling pathway identified through Ingenuity Pathway Analysis (IPA) (, Chlamydia trachomatis,Neisseria gonorrhoeae,Mycoplasmoides genitalium,Sequoia sempervirens,Prunus persica,Homo sapiens,Mus musculus,unidentified,NA)
• Signaling pathway model (, Saccharomyces cerevisiae,Arabidopsis thaliana,PX clade,Schizosaccharomyces pombe,Chlamydomonas reinhardtii,Phytophthora infestans,Marchantiophyta,Thalassiosira pseudonana,Stramenopiles,Volvox carteri,Opisthokonta,Phytophthora ramorum,Aureococcus anophagefferens,Karlodinium veneficum,Plasmodium falciparum,Toxoplasma gondii,Dictyostelium discoideum,Entamoeba histolytica,Tetrahymena thermophila,Alveolata,Neospora caninum,Dictyostelia,Physarum polycephalum,Toxoplasma gondii GT1,Dictyostelium purpureum,Malawimonas californiana,Homo sapiens,Bos taurus,Helicobacter pylori,Opsanus beta,Paramecium bursaria Chlorella virus 1,NA)
• Displays canonical BMP pathway identified through Ingenuity Pathway Analysis (IPA) (, Chlamydia trachomatis,Neisseria gonorrhoeae,Mycoplasmoides genitalium,Sequoia sempervirens,Prunus persica,Homo sapiens,Mus musculus,unidentified,NA)
• Implications of cell biological processes on innate immune signaling (, NA)
• Biosynthetic pathway: nucleic acid detection from within the cytosol (, NA)
• Portion of the miRNA-augmented Regulation of lipolysis in adipocytes pathway (, Homo sapiens,Candida dubliniensis)
• VHL Inactivation in Renal Cell Carcinoma: Implications for Diagnosis, Prognosis, and Treatment (, NA)
• The p53 tumor suppressor in metabolism and diabetes (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Intersectin scaffold proteins and their role in cell signaling and endocytosis (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Xenopus laevis,Human gammaherpesvirus 4,Human gammaherpesvirus 8,Oryzias latipes,Homo sapiens,Cryptococcus neoformans)
• Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment (, NA)
• An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p (, NA)
• Lymph node fibroblastic reticular cells in health and disease (, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Ebola virus,Zaire ebolavirus,Homo sapiens,Macaca mulatta,Cercocebus atys,Mus musculus,Leishmania major,NA)
• Visual integration of quantitative proteomic data, pathways and protein interactions (, NA)
• Structuring protein interactions around familiar canonical pathways provides intuitive visualizations (, NA)
• Analysis of a protein interaction network in the context of the T-cell pathway (, NA)
• Translational Control of Long-Lasting Synaptic Plasticity and Memory (, NA)
• Pathways activated following binding of the TSLP cytokine to its receptor complex (, NA)
• Naïve T cells are predominantly oxidative and constantly monitor their environment for immune insult (, Homo sapiens,Mus musculus,Listeria monocytogenes)
• Hedgehog Signaling in the Stomach (, NA)
• Human endometrial receptivity (, NA)
• Oscillatory Signaling and Network Responses during the Development of Dictyostelium discoideum (, NA)
• Oscillatory Signaling and Network Responses during the Development of Dictyostelium discoideum (, NA)
• INHIBITION OF MAPK AND STIMULATION OF AKT KINASE SIGNALING PATHWAYS: TWO APPROACHES WITH THERAPEUTIC POTENTIAL IN THE TREATMENT OF NEURODEGENERATIVE DISEASE (, NA)
• Prohibitin as the Molecular Binding Switch in the Retinal Pigment Epithelium (, Bos taurus,Oryctolagus cuniculus,Equus caballus,Panthera leo,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Human T-cell leukemia virus type I,Raphanus sativus,Homo sapiens,Salmonella enterica subsp. enterica serovar Typhi)
• Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target (, NA)
• Triggering Receptor Expressed on Myeloid Cells and 5′Adenosine Monophosphate-activated Protein kinase in the Inflammatory Response: A Potential Therapeutic Target (, NA)
• Signaling pathways mediating the dual roles of senescence-associated inflammatory cytokines in cancer development (, NA)
• Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,vectors)
• Downregulation of a GPCR by Beta-Arrestin2-mediated Switch from an Endosomal to a TGN Recycling Pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Nuclear DNA damage signalling to mitochondria in ageing (, NA)
• Signaling events leading to MYC and YAP upregulation (, Hepatitis B virus,Vesicular stomatitis virus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Glucose metabolism reprogrammed by overexpression of IKK-epsilon promotes pancreatic tumor growth (, NA)
• MITOCHONDRIAL FUNCTION IN HYPOXIC ISCHEMIC INJURY AND INFLUENCE OF AGING (, NA)
• Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia (, NA)
• Fine-tuning vascular fate during endothelial-mesenchymal transition (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Gallus gallus,Xenopus laevis,Homo sapiens)
• Regulation of macrophage function in tumors: the multifaceted role of NFKB (, Homo sapiens,Mus musculus)
• Targeting translation initiation bypasses signaling crosstalk mechanisms that maintain high MYC levels in colorectal cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• NFAT Proteins: Emerging Roles in Cancer Progression (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• SIRT1-AMPK metabolic control network (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Human immunodeficiency virus 1,Adenoviridae,Bikinia letestui,Homo sapiens,Danio rerio,Alphaproteobacteria)
• Molecular Basis of Pulmonary Alveolar Proteinosis (, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Listeria monocytogenes,Mus musculus,Rattus norvegicus,Pneumocystis carinii,Pneumocystis jirovecii,Homo sapiens,Plasmodium chabaudi,Gekko adenovirus)
• Stress kinases in the modulation of metabolism and energy balance (, Homo sapiens,Mus musculus)
• Wnt signaling is a complex pathway, believed to be involved in the regulation of divergent processes, including the maintenance of pluripotency and commitment to differentiation (, NA)
• Effect of estrogen (E2) on endothelial nitric oxide synthase (eNOS) (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model for the mechanism of SNRK regulation of ROCK activity (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana)
• Pathway to muscle fibrosis depends on myostatin stimulating the differentiation of fibro/adipogenic progenitor cells in chronic kidney disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus)
• TLR signaling pathway and ENU-induced mutations that impair TLR-dependent TNF or type I IFN secretion (, NA)
• ER stress-induced apoptotic pathways (, Homo sapiens,Mus musculus)
• Hijacking HES1: Tumors Co-opt the Anti-differentiation Strategies of Quiescent Cells (, NA)
• Condition-specific dependency network (CDN) for TG-101348-sensitive cell lines (, Homo sapiens,Mus musculus)
• Condition-specific dependency network (CDN) for indisulam for drug-sensitive cell lines (, Homo sapiens,Mus musculus)
• High levels of phosphotidyl inositol-protein kinase C signaling in the PFC markedly impair PFC function at the behavioral and cellular levels (, NA)
• Insulin Receptor Signaling Pathway Targeted by Surgery-Responsive microRNAs (, NA)
• Carcinogenic Effects of Oil Dispersants: a KEGG Pathway-based RNA-seq Study of Human Airway Epithelial Cells (, Odontesthes bonariensis,Odontesthes argentinensis,Homo sapiens,Mus musculus,Helicobacter pylori)
• Harnessing cancer cell metabolism for theranostic applications using metabolic glycoengineering of sialic acid in breast cancer as a pioneering example (, NA)
• Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy (, NA)
• G protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Candida dubliniensis,Meleagris gallopavo)
• Principles of Kinase Inhibitor Therapy for Solid Tumors (, NA)
• Models of checkpoint control in (a) S (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens)
• Rationale for combination therapy in lymphoma (, NA)
• Possible model for the interaction between A (, NA)
• Posttranslational modulation of FoxO proteins is associated with intricate cellular signal transduction pathways (, Saccharomyces cerevisiae,Vasconcellea candicans,Asarum minus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Human gammaherpesvirus 8,Sulfolobus turreted icosahedral virus 1)
• DNA damage and replication checkpoints in various organisms (, NA)
• Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer (, NA)
• Sites of action of curcumin on cancer cells (, NA)
• Multi-component nature of TGFB and Wnt Pathways (, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Examples of pathways that may be activated by EP2R and EP4R (, NA)
• Schematic drawing of the signal transduction pathways involved in human gingival fibroblast (HGF) migration including the possible effects of nicotine on these pathways (, NA)
• Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Heloderma suspectum)
• Signal transduction pathways and crosstalk activated by insulin/IGF-1 receptor and GPCR systems (, Homo sapiens,Mus musculus)
• Schematic demonstrating the signaling networks and their cross talks involved in differentiating the mesenchymal stem cells (MSCs) into osteoblasts (, NA)
• Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1 (, NA)
• Hypothetical model linking multiple biological pathways in the development of SS-like disease based on differentially expressed genes identified in lacrimal glands by global microarray analyses (, NA)
• Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors (, NA)
• Signaling pathway that connects store-operated Ca2+ entry with NFAT-dependent gene transcription in T cells (, Drosophila melanogaster,Homo sapiens)
• Biosynthesis of the lipid-linked oligosaccharide precursor for N-linked glycosylation and known defects in this pathway (, NA)
• Key role of the PI(3)K/Akt signalling in the cumulo-oocyte complexe survival (, NA)
• The two major transduction pathways of apoptotic signalling (, NA)
• Simplified scheme of the cAMP pathway and the regulation of renin synthesis and release (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Genetic and Developmental Basis of Cardiovascular Malformations (, Homo sapiens,Mus musculus,Drosophila melanogaster,Avian erythroblastosis virus E26)
• Posttranscriptional mechanisms of regulation of the miRNA biogenesis pathway (, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Pan troglodytes,Danio rerio,Sus scrofa,NA)
• Deubiquitinases in breast cancer (, NA)
• Novel targets for the treatment of autosomal dominant polycystic kidney disease (, Mus musculus,Rattus norvegicus,Bikinia letestui,Tripterygium wilfordii,Homo sapiens,Canis lupus familiaris,Streptomyces hygroscopicus)
• Novel targets for the treatment of autosomal dominant polycystic kidney disease (, Mus musculus,Rattus norvegicus,Bikinia letestui,Tripterygium wilfordii,Homo sapiens,Canis lupus familiaris,Streptomyces hygroscopicus)
• Simplified model of the signaling pathways regulating radiation-induced bystander effects (, Homo sapiens,Bos taurus,Armoracia rusticana,Dipturus trachyderma)
• Defective Treg cell suppressive mechanisms in IPEX and IPEX-like disorders (, Homo sapiens,Mus musculus)
• EDA signaling (, Homo sapiens,Mus musculus)
• Hypoxic signaling connected to Siah (, Saccharomyces cerevisiae,Erythrina poeppigiana,Saccharomyces cerevisiae PW5,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Mouse mammary tumor virus)
• Intrinsic and extrinsic factors used during vertebrate lens development (, Fragaria x ananassa,Alburnus alburnus,Homo sapiens)
• Growth Arrest-Specific 6 (GAS6) Promotes Prostate Cancer Survival by G1 Arrest/S Phase Delay and Inhibition of Apoptotic Pathway During Chemotherapy in Bone Marrow (, NA)
• Structure, Mechanism and Regulation of Pyruvate Carboxylase (, NA)
• NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection (, Brucella abortus,Homo sapiens)
• Schematized general estrogen signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) Pathway (, NA)
• Nox1/4 dual inhibitor GKT137831 or Nox4 knockdown inhibits Angiotensin-II-induced adult mouse cardiac fibroblast proliferation and migration. AT1 physically associates with Nox4 (, NA)
• PLCB – G protein signaling pathway showing how the binding of an extracellular to a transmembrane GPCR will activate a G protein heterotrimer whose G A or G BG subunits can bind to and activate PLC B (, NA)
• Inhibition of the NOTCH pathway by NUMB (, Mus musculus,Rattus norvegicus,Glycine max,Curcuma longa,Homo sapiens,Drosophila melanogaster,Gallus gallus)
• TGFB induces apoptosis in human B cells via transcriptional regulation of BIK and BCL-XL (, NA)
• Multifunctionality of Man-HA-MnO2 NPsaaMnO2 particles (~15 nm) are entrapped in hyaluronic acid (HA) with mannan molecules attached (, NA)
• Anaplastic Lymphoma Kinase (ALK) as a therapeutic target in non-small cell lung cancer (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,NA)
• Schematic summary of metabolic pathways disturbance caused by suppression of pyruvate carboxylase in MDA-MB-231-derived cell lines (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Differential gene expression in PPAR signaling pathway (, NA)
• Convergence of Pathways in TLR and IL-1R SignalingUpon activation, the IL-1 receptor dimerized with the IL-1 receptor accessory protein (, Staphylococcus aureus,Streptococcus pneumoniae,Streptomyces hygroscopicus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Oryctolagus cuniculus)
• Simplified scheme of early FcERI-mediated signaling events (, Homo sapiens,Mus musculus,Rattus norvegicus,Apis mellifera,Papio anubis,Trichinella spiralis,Toxicodendron radicans,Toxicodendron diversilobum,Klebsiella pneumoniae,Vaccinia virus,Atractaspis engaddensis)
• Metabolomics and Metabolic Diseases: Where do we stand? (, Mus musculus,Rattus norvegicus,Phocaeicola vulgatus,Prevotella copri,Homo sapiens,Xenopus laevis,gut metagenome)
• Opposing influences on Foxo cellular localization and transcriptional activity (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Human immunodeficiency virus)
• Brx-mediated osmotic stress-activated signaling system and its implications for the immune response (, Bos taurus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Gallus gallus,Helicobacter pylori)
• Human SRMAtlas: A resource of targeted assays to quantify the complete human proteome (, Mycobacterium tuberculosis,Streptococcus pyogenes,Homo sapiens,Saccharomyces cerevisiae)
• Canonical Wnt/b-catenin signaling pathway (, Mus musculus,Rattus norvegicus,Solanum lycopersicum,Lareunionomyces loeiensis,Homo sapiens,Paraechinus aethiopicus)
• Molecular cascades of fear memory stabilization in the amygdala (, NA)
• The kynurenine pathway with relevant regulatory components, summarizing gene expression and metabolite changes previously identified for schizophrenia in the frontal and anterior cingulate cortex (, Homo sapiens,Rattus norvegicus)
• Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion (, Mus musculus,Rattus norvegicus,Homo sapiens,teleost fish)
• TGF-b/BMP signaling pathway in osteoblast differentiation (, Mus musculus,Rattus norvegicus,Solanum lycopersicum,Lareunionomyces loeiensis,Homo sapiens,Paraechinus aethiopicus)
• Minimally oxidized LDL induces TLR4-dependent lipoprotein uptake by macrophages (, NA)
• Signaling complexes induced by TNFA to mediate NFKB activation, apoptosis and necroptosis (, NA)
• mTOR and cancer: many loops in one pathway (, Homo sapiens,Mus musculus,clinical samples)
• mTOR and cancer: many loops in one pathway (, Homo sapiens,Mus musculus,clinical samples)
• Mammalian autophagy: core molecular machinery and signaling regulation (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Eucalyptus intertexta,Homo sapiens,Dictyostelium discoideum)
• Mammalian autophagy: core molecular machinery and signaling regulation (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Eucalyptus intertexta,Homo sapiens,Dictyostelium discoideum)
• TOR-dependent control of autophagy: biting the hand that feeds (, NA)
• Autophagy Genes as Tumor Suppressors (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Impact of ELS on the normal development of tissues and organs (, NA)
• CD28 costimulation, IL-2 signaling, and mTOR pathway regulate Otub1 and GRAIL expression, controlling proliferation in primary naive CD4 T cells (, Homo sapiens,Macaca mulatta,Cercocebus atys,Mus musculus,Oryctolagus cuniculus,murine stem cell retroviral vector)
• Non-genomic estrogen mediated mechanisms of VSM contraction (, Homo sapiens)
• Non-genomic estrogen mediated endothelial pathways of vascular relaxation (, Homo sapiens)
• Microtubule motors drive Hedgehog signaling in primary cilia (, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Chlamydomonas reinhardtii)
• The mechanisms of retinoid induction of NIS expression in MCF-7 cells (, NA)
• Scheme of the autophagy pathway (, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Enterovirus C,Betapolyomavirus macacae,Coxsackievirus B3,Sindbis virus,Coxsackievirus,Murine hepatitis virus,Tobacco mosaic virus,Dengue virus type 2,Human rhinovirus sp.,Murid gammaherpesvirus 4,Human parvovirus B19,Hepatitis C virus genotype 1,SARS coronavirus LC3,dengue virus type I,Coxsackievirus B4,Dengue virus type 3,Human alphaherpesvirus 1 strain 17,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Toxoplasma gondii,Homo sapiens,NA,NA,NA,NA,NA)
• Clinical applications of mouse models for breast cancer engaging HER2/neu (, Mouse mammary tumor virus,Moloney murine leukemia virus,Venezuelan equine encephalitis virus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Decentralized model of endothelial mechanotransduction by shear stress (, NA)
• The Notch signaling pathway (, NA)
• New View into the Regulation of Purine Metabolism – The Purinosome (, Homo sapiens,Gallus gallus)
• New View into the Regulation of Purine Metabolism – The Purinosome (, Homo sapiens,Gallus gallus)
• Schematic presentation of Akt-mTOR signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,clinical samples)
• Schematic presentation of PI3K-Akt signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,clinical samples)
• Crosstalk between intracellular signaling pathways in female reproductive behavior (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Xenopus laevis,Cavia porcellus,Cricetus cricetus,Mesocricetus auratus,Coturnix coturnix,Coturnix japonica,Bos taurus,Oryctolagus cuniculus,Mustela putorius furo,Homo sapiens,Macaca radiata,Symphonia globulifera)
• Pharmacological and Immunological Targeting of Tumor Mesenchymalization (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples)
• Frequent amplification and overexpression of multiple EGFR-family-signaling components in non-small cell lung cancer (NSCLC) (, NA)
• Metabolic pathways active in proliferating cells are directly controlled by signaling pathways involving known oncogenes and tumor suppressor genes (, Homo sapiens,Saccharomyces cerevisiae,NA)
• Interconnections Between Autophagy and Integrin-Mediated Cell Adhesion (, NA)
• Mesenchymal Stem Cell Derived Secretome and Extracellular Vesicles for Acute Lung Injury and Other Inflammatory Lung Diseases (, NA)
• Main targets of RhoA and ROCK, involved in organization of the cytoskeleton (, NA)
• Nuclear Dynamics of Heterochromatin Repair (, NA)
• Viruses exploit host proteasome pathway for immune evasion (, DNA viruses,Homo sapiens)
• Viral regulation of host proteins via post translational modifications (, DNA viruses,Homo sapiens)
• Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis,Hepatitis B virus,NA)
• Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases (, Citrobacter rodentium,Helicobacter hepaticus,Homo sapiens,Mus musculus,Carpinus caroliniana)
• Immunoregulatory Functions of mTOR Inhibition (, NA)
• Mechanisms and clinical implications of hepatocyte lipoapoptosis (, Mus musculus,Rattus norvegicus,Candida dubliniensis,Bikinia letestui,Homo sapiens)
• Vitamin D3-driven signals for myeloid cell differentiation - Implications for differentiation therapy (, Homo sapiens,Mus musculus,Salvia rosmarinus)
• Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes: Are we getting closer? (, Homo sapiens,Mus musculus)
• Schematic diagram of molecular interactions stimulated by HMW-HA (, NA)
• Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1 (, Drosophila melanogaster,Caenorhabditis elegans,Dictyostelium discoideum,Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• Competition Among Stem Cells Gets Sticky (, Homo sapiens,Drosophila melanogaster)
• Identification of KRT16 as a Target of an Autoantibody Response in Complex Regional Pain Syndrome (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• MYC-mediated mRNA cap methylation of Wnt/Beta-catenin signaling pathway transcripts (, NA)
• BRD4 regulates breast cancer dissemination through Jagged1/Notch1 signaling (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Molecular Mechanisms of T cell Receptor and Costimulatory Molecule Ligation/Blockade in Autoimmune Disease Therapy (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Molecular Mechanisms of T cell Receptor and Costimulatory Molecule Ligation/Blockade in Autoimmune Disease Therapy (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Network of the genes related with post-translational modification, cancer, and tumor morphology (, Homo sapiens,Mus musculus,Capra hircus)
• Network of the genes related with cancer and DNA replication, recombination, and repair (, Homo sapiens,Mus musculus,Capra hircus)
• Functions of natural IgM in homeostasis maintenance and autoimmune diseases prevention; (A) sIgM enhances apoptotic cell clearance (, Lareunionomyces loeiensis,Aspergillus fumigatus,Agaricus bisporus,Mus musculus,Rattus norvegicus,Homo sapiens,Neisseria meningitidis,Gnathostomata,Heligmosomoides polygyrus)
• Routes of interaction between epoxyeicosanoid and endocannabinoid signaling pathways (, NA)
• Role of Radiation-induced TGF-beta Signaling in Cancer Therapy (, Mus musculus,Rattus norvegicus,Danio rerio,Dipturus trachyderma,Homo sapiens,Drosophila melanogaster,Hepatitis B virus)
• Modes of DNA synthesis (, Homo sapiens,Saccharomyces cerevisiae)
• Restoring sAPPA functions as a potential treatment for Alzheimer’s disease (, NA)
• Inflammatory role of phagocyte apoptotic pathways in rheumatic diseases (, NA)
• Cancer Therapies in HIV Cure Research (, Homo sapiens,Human immunodeficiency virus 1,Hepatitis B virus,Macaca mulatta,Mus musculus)
• Signaling pathway stimulated by cotinine.Stimulation of A7 nicotinic receptors activates PI3K leading to the activating phosphorylations on Akt, which phosphorylates the inhibitory Ser-9 of GSK3B, leading to pro-cognitive effects (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Nicotiana tabacum,Homo sapiens)
• Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Eucalyptus intertexta,Treponema pallidum)
• Schematic diagram illustrating the possible interplay between the EGFR and CK2 signaling pathways that regulate GBM cell proliferation (, NA)
• Unfolded protein response in immunity and inflammation (, Escherichia coli,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptomyces sp. sp1,Human alphaherpesvirus 1,Respiratory syncytial virus,Japanese encephalitis virus,Encephalomyocarditis virus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• Unfolded protein response in immunity and inflammation (, Escherichia coli,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptomyces sp. sp1,Human alphaherpesvirus 1,Respiratory syncytial virus,Japanese encephalitis virus,Encephalomyocarditis virus,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,NA)
• Molecular Origins of Cancer (, Homo sapiens,clinical samples)
• The genes involved in PCP signaling (, NA)
• CD40-mediated NFKB activation in B cells is increased in multiple sclerosis and modulated by therapeutics (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke (, NA)
• Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases (, NA)
• Epicardial-Myocardial Signaling Directing Coronary Vasculogenesis (, NA)
• General synthetic route to the racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues (1a–e, g, i–k) is shown in (, Streptococcus pneumoniae,Homo sapiens)
• Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases (, NA)
• Representation of the mechanisms of UV-induced cellular response in skin: 1) UV-radiation is absorbed by the genomic DNA and causes direct DNA damage through the formation of CPDs and (6–4) PPs (, NA)
• Telomeres: protecting chromosomes against genome instability (, NA)
• Telomeres: protecting chromosomes against genome instability (, NA)
• Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis (, Homo sapiens,Mus musculus,Staphylococcus aureus,Dipturus trachyderma)
• Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis (, Homo sapiens,Mus musculus,Staphylococcus aureus,Dipturus trachyderma)
• Group 1 mGluR-dependent synaptic long-term depression (mGluR-LTD): mechanisms and implications for circuitry & disease (, NA)
• Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis (, Homo sapiens,Mus musculus,Staphylococcus aureus,Dipturus trachyderma)
• DREAM as a novel therapeutic target for anti-thrombotic agents (, NA)
• Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration (, NA)
• Ingenuity®Pathway Analysis (IPA®) revealed significant overlap between the XDP signature and gene networks related to (A) RNA polymerase II (p = 1.19 × 10−6) and (B) NFKB (p = 1.36 × 10−12) (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Cricetus cricetus,Homo sapiens,Armoracia rusticana,Human immunodeficiency virus)
• Transposon mutagenesis identifies candidate genes that cooperate with loss of Transforming Growth Factor-beta signaling in mouse intestinal neoplasms (, NA)
• ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway via Zinc Finger Transcription Factor CREB (, NA)
• Pathogenesis of kidney disease in systemic lupus erythematosus (, NA)
• HNE formation and pathway of metabolism (, NA)
• Gasotransmitters in cancer: from pathophysiology to experimental therapy (, NA)
• Histone chaperone networks shaping chromatin function (, Saccharomyces cerevisiae,Xenopus laevis,Schizosaccharomyces pombe,Triportheus paranensis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Clinical imaging of cancer metabolism (, NA)
• Regulation of hepcidin expression in hepatocytes in response to iron status and requirements (left) or inflammation (right) (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Human immunodeficiency virus 1,Brucella abortus)
• Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort (, NA)
• Action of metformin (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Induction of IL-21 in Peripheral T Follicular Helper cells is Indicator of Influenza Vaccine Response in Previously Vaccinated HIV-Infected Pediatric Cohort (, NA)
• Glycogen Synthase Kinase-3B Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3 (, Mus musculus,Rattus norvegicus,Dipturus trachyderma,Homo sapiens)
• Utilizing a combination of immunoprecipitation (IP) and tandem mass spectrometry (MS) protein identification (ID), complemented by gene expression analysis, a comprehensive Ang-(1-7) stimulated Mas1 receptor signaling pathway was generated (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Citrus medica)
• Too Old to Fight? Aging and its Toll on Innate Immunity (, NA)
• Microbial Induction of Inflammatory Bowel Disease Associated Gene TL1A (TNFSF15) in Antigen Presenting Cells (, NA)
• Involvement of HMGN1 in TCR (, NA)
• Emerging roles of p53 and other tumour-suppressor genes in immune regulation (, Influenza A virus,Human papillomavirus,unidentified influenza virus,Human gammaherpesvirus 8,Vaccinia virus,Enterovirus C,Betapolyomavirus macacae,Sindbis virus,Homo sapiens,Mus musculus,NA,NA)
• The DNA Damage Response During the Life Cycle of Human Papillomaviruses (, NA)
• The DNA Damage Response During the Life Cycle of Human Papillomaviruses (, NA)
• HPV E6 and E7 interacts with core components of the interferon pathway (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,H1N1 subtype,Adeno-associated virus,West Nile virus,Enterovirus C,Simian immunodeficiency virus,Alphapapillomavirus 7,human papillomavirus 11,human papillomavirus 31,Bovine papillomavirus,Human papillomavirus 38,Mus musculus papillomavirus type 1,Homo sapiens,Mus musculus,NA)
• Diverse role of Survival Motor Neuron Protein (, NA)
• Intersections of Post-Transcriptional Gene Regulatory Mechanisms with Intermediary Metabolism (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Oryctolagus cuniculus,NA)
• Simplified schematic of the T cell receptor signaling pathway (, NA)
• Simplified schematic of the IgE receptor (FcERI) signaling pathway (, NA)
• Programmed cell death as a defence against infection (, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Pseudomonas syringae,Vibrio cholerae,Bacillus anthracis,Escherichia coli IS1,Shigella flexneri,Haemophilus influenzae,Citrobacter rodentium,Francisella tularensis,Mycobacterium avium,Neisseria gonorrhoeae,Serratia marcescens,Yersinia pestis,Streptococcus sp. group B,Yersinia enterocolitica,Francisella tularensis subsp. novicida,Yersinia pseudotuberculosis,Chromobacterium violaceum,Burkholderia thailandensis,bacterium B,Burkholderia mallei,Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Vesicular stomatitis virus,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Encephalomyocarditis virus,Murine hepatitis virus,Saccharomyces cerevisiae,Arabidopsis thaliana,Candida albicans,Mus musculus,Chinchilla chinchilla,Homo sapiens,Equus caballus,prion,Calloplesiops altivelis)
• A signaling cascade activated by opiates (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Human immunodeficiency virus 1)
• Programmed cell death as a defence against infection (, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Pseudomonas syringae,Vibrio cholerae,Bacillus anthracis,Escherichia coli IS1,Shigella flexneri,Haemophilus influenzae,Citrobacter rodentium,Francisella tularensis,Mycobacterium avium,Neisseria gonorrhoeae,Serratia marcescens,Yersinia pestis,Streptococcus sp. group B,Yersinia enterocolitica,Francisella tularensis subsp. novicida,Yersinia pseudotuberculosis,Chromobacterium violaceum,Burkholderia thailandensis,bacterium B,Burkholderia mallei,Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Vesicular stomatitis virus,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Encephalomyocarditis virus,Murine hepatitis virus,Saccharomyces cerevisiae,Arabidopsis thaliana,Candida albicans,Mus musculus,Chinchilla chinchilla,Homo sapiens,Equus caballus,prion,Calloplesiops altivelis)
• Role and mechanism of action of Sclerostin in bone (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis)
• Schematic diagram demonstrating the mechanism of action of perlecan and endorepellin in angiogenesis and autophagy (, NA)
• Cross-Talk between the Cytoplasmic RIG-I and STING Sensing Pathways (, NA)
• Understanding the intersections between metabolism and cancer biology (, NA)
• High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity (, NA)
• Inference of Cancer Mechanisms through Computational Systems Analysis (, NA)
• STAT3-dependent negative regulation of DCs induced by HDAC inhibition (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Xenopus laevis)
• Canonical Wnt/Beta-catenin pathway (modified after ()) (, NA)
• Seoul virus suppresses NFKB-mediated inflammatory responses of antigen presenting cells from Norway rats (, NA)
• The dendrimer-based nanoplatform for targeted delivery of DJ-1 siRNA to the ovarian cancer cells via LHRH receptor-mediated endocytosis and the role of siRNA-induced suppression of DJ-1 protein in the combinatorial treatment (, NA)
• The role of Rho GTPase/Rho kinase signaling pathway in regulation of actin cytoskeletal organization and cellular processes in smooth muscle and non-smooth muscle cells (, Bos taurus,Oryctolagus cuniculus,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens,Broussonetia kazinoki)
• DNA polymerase beta germline variant confers cellular response to cisplatin therapy (, NA)
• CD62L regulation by T-cell receptor (TCR) stimulation and Gc-cytokines (, Influenza A virus,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Vesicular stomatitis virus,Murid betaherpesvirus 1,Variola virus,Homo sapiens,Mus musculus,Gallus gallus,Listeria monocytogenes)
• Neurotrophin actions on the endothelial cell (, NA)
• Necrototic pathway (, Homo sapiens,Mus musculus)
• Cytokine signaling through the JAK/STAT pathway (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Influenza A virus,Listeria monocytogenes,Borreliella burgdorferi,Homo sapiens)
• Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines using TMT 10-plex Isobaric Labeling (, Saccharomyces cerevisiae,Agriosomyces longus,Homo sapiens,Mus musculus)
• Involvement of GSK3 in TLR4 signaling pathways.Activation of TLR4 by LPS or alarmins (called ligand in the figure) involves dimers of TLR4 binding to CD14 and MD-2 (, Mus musculus,Rattus norvegicus,gut metagenome,human metagenome,Homo sapiens,Mycolicibacterium vaccae)
• Role of the ubiquitin–proteasome pathway in long-term facilitation in Aplysia (, NA)
• Chronic lymphocytic leukaemia (, NA)
• HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways (, Human alphaherpesvirus 1,West Nile virus,Enterovirus C,Human alphaherpesvirus 2,Human alphaherpesvirus 3,Mus musculus,Cavia porcellus,Cricetulus griseus,Homo sapiens,NA)
• Regulation and function of SK1 (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Homo sapiens)
• Post-transcriptional regulation of cytokine and growth factor signaling in cancer (, NA)
• Regulation of MUC4 expression (, NA)
• Mechanisms by which mild mitochondrial uncoupling protects neurons against oxidative stress, excitotoxicity and the accumulation of disease-related self-aggregating proteins such as amyloid Beta-peptide, Tau and Alpha-synuclein (, NA)
• The signaling pathways involved in the migration induced by G-CSF in human trophoblast Swan 71 cells (, NA)
• Modeling, Signaling and Integrated Modeling-experimental Frameworks in Cell Migration (, NA)
• Transforming growth factor beta (TGFB) and inflammation in cancer (, unidentified influenza virus,Mouse mammary tumor virus,Homo sapiens,Mus musculus)
• GSK3: a multifaceted kinase in Wnt signaling (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Xenopus laevis)
• Autophagy in infection, inflammation, and immunity (, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human gammaherpesvirus 8,Measles morbillivirus,Sindbis virus,Murid gammaherpesvirus 4,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus sp. group A,Anaplasma phagocytophilum,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,NA,NA)
• Notch, lipids, and endothelial cells (, NA)
• Schematic diagram shows projections of midbrain dopaminergic projections (ventral tegmental area or substantia nigra) to the frontal cortex and striatum and intracellular signaling pathway in a D1 receptor synapse (, NA)
• Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders (, NA)
• PI3K-Akt pathway negatively regulates LPS signaling and gene expression in mouse macrophages by inhibiting the activation of MAPKs (, Mus musculus,Homo sapiens)
• Plane facts of PCP in the CNS (, NA)
• Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms (, NA)
• Therapeutic Targeting of Signaling Pathways in Muscular Dystrophy (, NA)
• Signaling pathways triggered by GDNF activation of the RET transmembrane receptor (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Xenopus laevis)
• TNFSFR and NFKB signaling activation during macrophage activation: CpG late responses (, NA)
• Sonic Hedgehog, Wnt and TGFB signaling pathway gene expression in CpG late treated macrophages [; ; ; ], see discussion (, NA)
• Basic components of the NOTCH signaling pathway (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Xenopus laevis)
• CONVERTING HUMAN PLURIPOTENT STEM CELLS INTO BETA CELLS: RECENT ADVANCES AND FUTURE CHALLENGES (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Ras-MapK pathway (, NA)
• PD-1 signaling (, Homo sapiens,Macaca mulatta,Pan troglodytes,Human papillomavirus,Vaccinia virus,Mus musculus,NA,NA)
• Activation of membrane-bound GCs by intracellular signals (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Crosstalk between autophagy and inflammatory signaling pathways: balancing host defence and homeostasis (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,unidentified influenza virus,Measles morbillivirus,Human alphaherpesvirus 2,Sindbis virus,Yellow fever virus,Rift Valley fever virus,Murid gammaherpesvirus 4,Murine norovirus,Murid herpesvirus 68,Staphylococcus aureus,Mycobacterium tuberculosis,Listeria monocytogenes,Borreliella burgdorferi,Citrobacter rodentium,Legionella pneumophila,Brucella abortus,Drosophila melanogaster,Caenorhabditis elegans,Toxoplasma gondii,Plasmodium vivax,Lareunionomyces loeiensis,Aspergillus fumigatus,Homo sapiens,Mus musculus)
• WWOX gene and gene product: tumor suppression through specific protein interactions (, NA)
• Regulation of autophagy induction in yeast and mammalian cells (, Saccharomyces cerevisiae,Arabidopsis thaliana,Komagataella pastoris,Yarrowia lipolytica,Ogataea angusta,Drosophila melanogaster,Caenorhabditis elegans,Dictyostelium discoideum,Mus musculus,Rattus norvegicus,Mycobacterium tuberculosis,Streptococcus pyogenes,Homo sapiens)
• Metabolic interactions with cancer epigenetics (, NA)
• Autophagy regulation in response to stress (, Saccharomyces cerevisiae,Komagataella pastoris,Yarrowia lipolytica,Ogataea angusta,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Mycobacterium tuberculosis,Listeria monocytogenes,Homo sapiens,Human alphaherpesvirus 1,NA)
• NKT cells in immune-mediated pregnancy loss (, NA)
• Metabolic reprogramming, caloric restriction and aging (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae)
• Innate antiviral immunity in Drosophila (, NA)
• Proteins Secreted By Embryonic Stem Cells Activate Cardiomyocytes Through Ligand Binding Pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Sequoia sempervirens,Homo sapiens)
• Cell cycle proteins as promising targets in cancer therapy (, NA)
• Major pattern recognition receptors (PRRs) that sense RNA and DNA virus pathogen associated molecular patterns (PAMPs) in the cytosol (, Human immunodeficiency virus 1,Hepatitis B virus,Human alphaherpesvirus 1,Human papillomavirus,Human betaherpesvirus 5,Vaccinia virus,Murid betaherpesvirus 1,Murine leukemia virus,Virus-associated RNAs,Homo sapiens,Mus musculus,prion,synthetic construct,NA,NA)
• Constitutive low levels of IFNB that are produced by most cell types “prime” type I IFNs producing cells for a robust type I IFNs production upon sensing “danger” signals such as cytosolic DNA and TLR ligands (, Homo sapiens,Mus musculus,Bos taurus,Francisella tularensis)
• Role of Aim2 protein in non lupus-prone and lupus-prone strains of mice in the regulation of type I IFNs production (, Homo sapiens,Mus musculus,Bos taurus,Francisella tularensis)
• Signaling Mechanisms in Thyroid Hormone-Induced Cardiac Hypertrophy (, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Cerobasis alpha)
• Viral infections in type 1 diabetes mellitus — why the B cells? (, NA)
• Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Deregulation of sphingolipid metabolism in Alzheimer's disease (, NA)
• Summary of identified microRNAs that target key proteins of autophagic pathway for regulation of autophagy (, NA)
• Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy (, Homo sapiens,Mus musculus)
• Junctional complex in the paracellular pathway of the BBB (, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Equus caballus,Cavia porcellus,Homo sapiens)
• Yeast mitogen-activated protein kinase signaling pathway, illustrating the signaling paths in responses to different signals (, Saccharomyces cerevisiae,Saccharomyces cerevisiae RM11-1a,Homo sapiens)
• Examples of Metabolic Pathway Linking Gut Microbiota to Cardiovascular Diseases (, NA)
• Therapeutic small-molecules target inhibitor of apoptosis proteins in cancers with deregulation of extrinsic and intrinsic cell death pathways (, Homo sapiens,Mus musculus,Ovis aries,Human papillomavirus)
• Interplay between immune checkpoint proteins and cellular metabolism (, Homo sapiens,Mus musculus)
• Putative mechanism by which the UPS acts downstream of BDNF/TrkB signaling to ultimately regulate Alpha-synuclein aggregation (, Homo sapiens,Papio hamadryas,Callithrix jacchus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Saccharomyces cerevisiae,prion,Tetronarce californica)
• Intrinsic and extrinsic apoptotic pathways, the TRADD/NFKB survival pathway, and the growth factor (GF) receptors PI3K/AKT pro-survival signaling axis in CSCs (, NA)
• 11-Step Enantioselective Synthesis of (−)-Lomaiviticin Aglycon (, NA)
• microRNAs in lipoprotein metabolism and cardiometabolic disorders (, Homo sapiens,Mus musculus,Opsanus beta,NA)
• Myelodysplastic syndromes: updates and nuances (, Homo sapiens,Mus musculus,Human parvovirus B19)
• Tissue Factor-Factor VIIa Complex Triggers Protease Activated Receptor 2-Dependent Growth Factor Release and Migration in Ovarian Cancer (, Homo sapiens,Mus musculus,Armoracia rusticana)
• Insulin and IGF1 signaling pathway to promote glucose uptake by GluT3 in neurons (shown) or GlutT4 in muscle (not shown) (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,Canis lupus familiaris)
• Beta-AR-dependent translation initiation (, Homo sapiens,Mus musculus)
• An Overview of IL-7 Biology and Its Use in Immunotherapy (, NA)
• The current understanding of PELP1 signaling pathway (, NA)
• PPARG targeted oral cancer treatment and additional utility of genomics analytic techniques (, NA)
• An intricate gene regulatory network controls OL differentiation (, NA)
• Hippo pathway (, NA)
• Autoimmunity in vitiligo is driven by the IFN-Gamma-CXCL10 cytokine signaling pathway (, Homo sapiens,Mus musculus,Ginkgo biloba)
• Kinase signaling and targeted therapy for primary myelofibrosis (, Homo sapiens,Mus musculus,Myeloproliferative leukemia virus,Rana aurora)
• Role of Autophagy in HIV Pathogenesis and Drug Abuse (, NA)
• Schematic diagram showing the neuroprotective effect of celastrol on Cd-induced apoptosis in neuronal cells (, NA)
• Smad Signaling in Skeletal Development and Regeneration (, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Papio ursinus)
• Canonical and Noncanonical Inflammasome (, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Vibrio cholerae,Clostridioides difficile,Bacillus anthracis,Shigella flexneri,Citrobacter rodentium,Francisella tularensis,Clostridioides difficile CD3,Helicobacter hepaticus,Mycobacteroides abscessus,Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Galatella linosyris)
• Regulation of NOX by H (, Helicobacter pylori,Homo sapiens)
• Metabolic reprogramming in T cell fate and function (, NA)
• Impact of CTLA-4 Ig versus anti-CD28 domain Abs on alloreactive T cell responses (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Prunus persica)
• GPCR signaling can be mediated by receptor-interacting proteins (, NA)
• IFITM Proteins Mediate the Innate Immune Response to Influenza A H1N1 Virus, West Nile Virus and Dengue Virus (, NA)
• Entry into an ICL repair pathway depends on the mode of recognition (, NA)
• Biomechanical relationships between the corneal endothelium and Descemet’s membrane (, NA)
• Induction of glycolytic and tricarboxylic acid cycle enzymes by M-CSF and GM-CSF (, NA)
• Complement Factors and their G Protein Coupled Receptors in Neuroprotection and Neurodegeneration (, Mus musculus,Rattus norvegicus,Homo sapiens)
• RSK in Tumorigenesis: Connections to Steroid Signaling (, NA)
• REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS (, NA)
• Myosin II Light Chain Phosphorylation Regulates Membrane Localization and Apoptotic Signaling of Tumor Necrosis Factor Receptor-1 (, Mus musculus,Arabidopsis thaliana,Canis lupus familiaris,Homo sapiens)
• TLRs signaling pathway showed on TLR2 example (, Staphylococcus aureus,Mycobacterium tuberculosis variant bovis BCG,Porphyromonas gingivalis,Borreliella burgdorferi,Salmonella enterica subsp. enterica serovar Typhi,Leptospira interrogans,Drosophila melanogaster,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Respiratory syncytial virus,Plasmodium falciparum,Trypanosoma cruzi,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens)
• TRL2 pathway is activated by Tollip and results in IRAK suppression (, Staphylococcus aureus,Mycobacterium tuberculosis variant bovis BCG,Porphyromonas gingivalis,Borreliella burgdorferi,Salmonella enterica subsp. enterica serovar Typhi,Leptospira interrogans,Drosophila melanogaster,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Respiratory syncytial virus,Plasmodium falciparum,Trypanosoma cruzi,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens)
• Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair (, NA)
• A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance (, NA)
• Wnt signaling and cellular metabolism in osteoblasts (, NA)
• Proposed signaling pathway by which AngII inhibits the activity of ROMK channels in the CCD from LK-fed rats (, NA)
• Heterotrimeric G Proteins and Apoptosis: Intersecting Signaling Pathways Leading to Context Dependent Phenotypes (, Clostridioides difficile,Clostridioides difficile CD3,Pasteurella multocida,Clostridioides difficile CD8,Clostridioides difficile CD47,Pasteurella multocida subsp. multocida,Mus musculus,Rattus norvegicus,Cricetulus griseus,Cricetus cricetus,Bos taurus,Canis lupus familiaris,Oryzias latipes,Fundulus heteroclitus,Homo sapiens,Toxoplasma gondii)
• How the PI3K-AKT and MEK-ERK pathways regulate apoptosis in EGFR driven cancers (, Homo sapiens,Mus musculus)
• Comparison of gene expression in peripheral blood cells stratified by the C8orf13-BLK variants rs2736340-rs13277113 heterozygote versus homozygote in SSc demonstrates alterations in B Cell Receptor Signaling Pathway (A) and NFKB Signaling Pathway (B) (, Homo sapiens,Mus musculus,Bos taurus,Mouse mammary tumor virus)
• Portrayed here is a molecular pathway analysis of genes regulated in the mouse nucleus accumbens by a direct infusion of the HDAC inhibitor MS-275 after chronic social defeat stress (, NA)
• Structure and signalling in the IL-17 receptor superfamily (, NA)
• Roles of Caspases in Necrotic Cell Death (, NA)
• Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets (, NA)
• Intracellular signalling pathways for migration (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Reactive oxygen species (ROS) induced damage in diabetic endothelial cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Canonical and non-canonical NFKB pathways (, NA)
• Activation modes of NFKB in the pathogenesis of B cell lymphoma (, NA)
• Apoptotic pathways of NFKB: TRAIL mediating the extrinsic pathway and p53 mediating the intrinsic pathway (, NA)
• Therapeutic targets in B cell lymphoma of NFKB activation (, NA)
• MTOR signaling pathway (, NA)
• Diagnosis and Management of Autoimmune Cytopenias in Childhood (, Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Helicobacter pylori)
• Redox signaling responses in DCs and T cells during T cell activation (, NA)
• AURKA interactions (, NA)
• Mechanism, consequences and therapeutic targeting of abnormal IL-15 signaling in cutaneous T-cell lymphoma (, Capra hircus,Equus asinus,Homo sapiens,Mus musculus,clinical samples)
• Innate immune evasion strategies of influenza viruses (, Influenza A virus,Influenza B virus,Homo sapiens)
• Innate immune evasion strategies of influenza viruses (, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Orthomyxoviridae,H1N1 subtype,H5N1 subtype,H3N2 subtype,Influenza A virus H3N2,H9N2 subtype,Influenza B virus,Swine influenza virus,Stealth virus 1,H7N7 subtype,Canis lupus familiaris,Sus scrofa,Equus caballus,Felis catus,Mustela putorius furo,Mustela lutreola,Sus scrofa domesticus,Myrmecophaga tridactyla,Mus musculus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus)
• Suggested signaling of the early stages of 1,25D-induced monocytic differentiation (, NA)
• Transcriptional regulation of the differentiation of Th2 cells (, Homo sapiens)
• Transcriptional regulation of the differentiation of Th1 cells (, Homo sapiens)
• Urine-based assays for the detection of bladder cancer (, NA)
• Heat-labile Enterotoxins as Adjuvants or Anti-Inflammatory Agents (, Escherichia coli,Vibrio cholerae,Clostridioides difficile,Streptococcus mutans,Clostridioides difficile CD3,Clostridioides difficile CD8,Clostridioides difficile CD40,Clostridioides difficile CD86,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Lipid Kinase Activity: PI3Ks are classically well known for this lipid kinase activity (, NA)
• Heart Failure in Pediatric Patients with Congenital Heart Disease (, Homo sapiens,Mus musculus,Panthera pardus)
• Regulation of SUMOylation pathway (, NA)
• Autophagy signaling pathway in C (, Caenorhabditis elegans,Homo sapiens)
• Summary of potential mechanism by which altered OC nAChR activity may drive structural and functional changes observed in cochleae of A9 null mice (, NA)
• Caspase Mediated Cleavage, IAP Binding and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NFKB Signaling (, Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Oryctolagus cuniculus)
• Genetic Susceptibility to Lymphoma (, NA)
• Chemotactic signalling in neutrophils (, Homo sapiens)
• This model illustrates the circadian rhythm in chicken cone photoreceptors (, NA)
• Ras signaling in early B cell development (, Homo sapiens,Mus musculus)
• Colorectal cancer (CRC) stem cell model (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Contemporary approaches to modulating the nitric oxide-cGMP pathway in cardiovascular disease (, NA)
• An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling (, NA)
• Regulation of Cell Cycle and RNA Transcription Genes Identified by Microarray Analysis of PC-3 Human Prostate Cancer Cells Treated with Luteolin (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Raphanus sativus,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Drosophila melanogaster)
• Oxidative stress and glutathione in TGF-Beta-mediated fibrogenesis (, NA)
• Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Nuclear phosphoinositide-mediated stress response pathway (, NA)
• GSK3 regulation of STATs, Smads, Beta-catenin, and NFAT (, NA)
• Signaling networks activating the canonical RAF-MEK-ERK signaling pathway and that have been involved in SCLC metastasis (see text) (, NA)
• The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5) (, NA)
• Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists (, Homo sapiens)
• Central BCR signaling network constructed from literature (, NA)
• Insulin receptor signaling pathways (, Homo sapiens)
• Molecular genetics of osteosarcoma (, NA)
• Interluekin-17A (IL17A) (, NA)
• Choose your own adventure: The role of histone modifications in yeast cell fate (, Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Sesamum indicum,Nakaseomyces glabratus,Homo sapiens,Mus musculus)
• Complement Anaphylatoxins, C5a and C3a, Suppress Interferon-Beta Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway (, Listeria monocytogenes,Homo sapiens)
• Cartoon showing the multiple inputs regulating the function of a conventional PKC (, Mus musculus,Rattus norvegicus,Lavandula angustifolia,Croton tiglium,Homo sapiens,Cerobasis alpha)
• Cell cycle phases and two examples of independent core pathways in the G1 stage (, NA)
• Cartoon illustrating two independent parallel pathways in the post-mitosis G1 phase (G1-pm) in cell proliferation: MAPK and the Hippo pathways (, NA)
• New Milestones Ahead in Complement-Targeted Therapy (, Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,Porphyromonas gingivalis,Neisseria meningitidis,Homo sapiens,Mus musculus,Cavia porcellus,Macaca fascicularis,Sus scrofa,Lareunionomyces loeiensis,Vaccinia virus)
• Proposed model for FoxO1 and AMPK regulation of EtOH-induced autophagy (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Armoracia rusticana,Homo sapiens)
• From neuronal activity to the actin cytoskeleton: a role for CaMKKs and ßPIX in spine morphogenesis (, NA)
• Schematic illustrating our strategy to generate iPSCs resistant to IL-1-mediated signaling for tissue engineering applications (, NA)
• Pulsatile GnRH secretion: Roles of G protein-coupled receptors, second messengers and ion channels (, NA)
• Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine (, NA)
• Hexosamine Signaling Pathway: O-GlcNAc cycling in feast or famine (, NA)
• The Hexosamine Signaling Pathway (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Activation of the NFKB signaling pathway by farnesol is related to ER stress (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Candida albicans,Aspergillus nidulans,Ocimum basilicum,Myristica fragrans,Mentha spicata,Cymbopogon citratus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Mesocricetus auratus,Homo sapiens)
• Farnesol induces ER stress and activation of the unfolded protein response (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Candida albicans,Aspergillus nidulans,Ocimum basilicum,Myristica fragrans,Mentha spicata,Cymbopogon citratus,Mus musculus,Rattus norvegicus,Cricetulus griseus,Mesocricetus auratus,Homo sapiens)
• Primary Cilium as a Complex Signaling Center (, NA)
• Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias (, NA)
• Nutrient sensing and inflammation in metabolic diseases (, NA)
• Coupling between Akt-mediated cellular energy metabolism, cell survival and proliferation (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Caenorhabditis elegans,Xenopus laevis,Murine leukemia virus)
• Regulation of autophagy and apoptosis (, NA)
• VDR-dependent and auxiliary pathways that lead to deltanoid-induced monocytic differentiation of myeloid leukemia cells (, NA)
• The postulated signaling of MAP kinase pathway in proliferating or differentiating HL60 cells (, Homo sapiens)
• AITC metabolism through the mercapturic acid pathway (, NA)
• THE ROLE OF ESTROGEN AND RECEPTOR AGONISTS IN MAINTAINING ORGAN FUNCTION AFTER TRAUMA-HEMORRHAGE (, NA)
• Fatty acid binding protein-1 (FABP1) and the human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias (, NA)
• GSK-3B modulation of LKB1-AMPK pathway in autophagy induction (, NA)
• Material Cues as Potent Regulators of Epigenetics and Stem Cell Function (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Bos taurus,Gallus gallus)
• High-Throughput Screening of Tyrosine Kinase Inhibitor Cardiotoxicity with Human Induced Pluripotent Stem Cells (, Armoracia rusticana,Diaporthe sclerotioides,Triticum aestivum,Matthiola incana,Homo sapiens,Mus musculus,Danio rerio,Coxsackievirus B3,archaeon RC26,NA)
• NFATc1 Mediates Vascular Endothelial Growth Factor-induced Proliferation of Human Pulmonary Valve Endothelial Cells (, Homo sapiens,Mus musculus)
• Simplified diagram of the unfolded protein response (, Homo sapiens,Rattus norvegicus,Drosophila melanogaster,Oryctolagus cuniculus,Armoracia rusticana,Human immunodeficiency virus)
• PACAP/PAC1 receptor signaling to ERK activation (, Mus musculus,Oryctolagus cuniculus,Cavia porcellus,Equus asinus,Homo sapiens,Matthiola incana)
• HDL, ABCA1 and ABCG1 transporters in cholesterol efflux and immune responses (, NA)
• TK-mediated signaling pathway promoting HaCaT keratinocyte migration (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Target genes, Gnas, Got2 and Snord32a, following tenofovir exposure of primary osteoclasts (, Homo sapiens,Macaca mulatta,Mus musculus,Human immunodeficiency virus)
• Top illustration shows disruptions in normal cell survival and normal apoptosis in glioblastoma (, NA)
• Pathophysiology and management of CVD (, Salvia miltiorrhiza,Ginkgo biloba,Centella asiatica,Aesculus hippocastanum,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus)
• Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action (, Homo sapiens)
• Targeting molecular pathway (, NA)
• Cytokine Decoy and Scavenger Receptors as Key Regulators of Immunity and Inflammation (, NA)
• The putative role of central insulin resistance in attenuating leptin modulation of rHypoE-19 hypothalamic neurons (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma (, NA)
• Simplified diagram of the angiogenesis pathway with anti-angiogenic targets and select compounds exploiting them (, NA)
• Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases (, NA)
• Gene program of neutrophil recruitment and tissue injury based on gene expression and in vitro data (, NA)
• Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells (, Homo sapiens)
• Working model of TGFB and NFKB pathway interactions that regulate GCT viability (, NA)
• Tale of Transforming Growth FactorB (TGFB) Signaling: A Soigné Enigma (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Homo sapiens,Bos taurus,Moloney murine sarcoma virus)
• Signaling network model for heart valve development and remodeling (, NA)
• Simplified overview of the canonical Wnt/Beta-catenin signaling pathway (, NA)
• Wnt signaling pathway involvement in cancer and neurodegeneration (, NA)
• BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN (, NA)
• BIOLOGY OF VASCULAR MALFORMATIONS OF THE BRAIN (, NA)
• The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections (, Porphyromonas gingivalis,Fusobacterium nucleatum,Aggregatibacter actinomycetemcomitans,Tannerella forsythia,Prevotella intermedia,Veillonella parvula,Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris)
• Hepatocyte expression of Serum Response Factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice (, Mus musculus,Rattus norvegicus,Homo sapiens,Matthiola incana)
• Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas (, Saccharomyces cerevisiae,Bikinia letestui,Homo sapiens,clinical samples)
• RFC-PCNA complex inhibiting cell proliferation (, Homo sapiens,Chlorocebus aethiops,Paracentrotus lividus,Parechinus angulosus)
• TGF-Beta-mediated signaling function in epithelia including the seminiferous epithelium of adult rat testes (, NA)
• Network diagram of Sp1-interacting proteins (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana,Human immunodeficiency virus,vectors,Paramormyrops ntotom,NA)
• Signaling mechanisms for PGF2A and AL-8810 stimulation of FP receptor (, NA)
• Shared coregulator GRIP1 in the GR and type I IFN signaling networks (, NA)
• Initial steps of PR activation (, NA)
• Genomic and nongenomic cross talk of the GnRHR and GR signaling pathways on the GnRHR promoter in LBT2 cells (, NA)
• Proposed Model for the Intracellular Mechanism of CART Action in Bovine GCsFSH stimulates Erk1/2 and Akt activation whereas CART treatment accelerates the termination of FSH-induced Erk1/2 and Akt signaling (, NA)
• Possible Signaling Pathway that Mediates FSH-Induced Meiotic Resumption of Mouse OocytesAfter binding with its membrane-integrated receptor in cumulus cells, FSH uses PKAII as a downstream mediator after a transient increase of cAMP (, Mus musculus,Homo sapiens)
• Signaling Pathways for Permitting Cross Talk between WNT and GnRHThe shaded pathway represents the skeletal features of the canonical Wnt/Beta-catenin signal transduction pathway (, NA)
• Proposed schematic of ACh-induced neuroprotection (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Sus scrofa,Mus musculus,Rattus norvegicus,Glycine max,Human immunodeficiency virus 1,Homo sapiens)
• FA/BRCA DNA damage response pathway (, Homo sapiens,Diaporthe sclerotioides,Human papillomavirus)
• Toll-like receptor signaling in cell proliferation and survival (, NA)
• Toll-like receptor signaling in cell proliferation and survival (, NA)
• MicroRNA function in Drosophila memory formation (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Agaricus bisporus)
• Ingenuity Pathway Analysis network showing the relationships between several assayed genes (emphasized with black arrows) (, NA)
• Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy (, Staphylococcus aureus,Streptomyces hygroscopicus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Various roles of C3 in complement activation and effector functions (, NA)
• Regulation of expression of hyperalgesic priming by estrogen receptor alpha in the rat (, NA)
• Glutamine/glutamate utilization in proliferating cells (, Escherichia coli,Dickeya chrysanthemi,Homo sapiens,Mus musculus)
• Serine/glycine metabolism in proliferating cells (, Escherichia coli,Dickeya chrysanthemi,Homo sapiens,Mus musculus)
• Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host (, NA)
• Pathogenic Bacterial Proteins and their Anti-Inflammatory Effects in the Eukaryotic Host (, NA)
• Maternal obesity on placental function and fetal development (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Type II Transmembrane Serine Protease Mediated Signaling in Cancer (, NA)
• Microarray profiling of 467 human GBMs discovered that polo-like kinase 1 (PLK1) was highly expressed in these tumors and that it clustered with the proliferative subtype (, NA)
• Nitric oxide (NO) as a mediator of cancer phenotype has led researchers to investigate strategies for manipulating in vivo production and exogenous delivery of this molecule for therapeutic gain (, NA)
• Idelalisib impacts cell growth through inhibiting translation regulatory mechanisms in mantle cell lymphoma (, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Matthiola incana)
• Signal transduction pathways and targets in paediatric Burkitt lymphoma (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4,Sequoia sempervirens)
• Cell–cell communication and cyclic AMP coordinates oocyte meiotic maturation in worms and mammals (, Homo sapiens,Caenorhabditis elegans)
• A) IPA analysis suggests the involvement of signaling by ITAMs (immunoreceptor tyrosine-based activation motifs) in the FcGR pathway at 24h (, Mus musculus,Rattus norvegicus,Acomys percivali,Acomys kempi,Homo sapiens,Danio rerio)
• Ischemia leads to inflammation, tissue injury, and ROS production, which, when coupled with reperfusion can lead to injury (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Equus caballus,Elephas maximus,Mus musculus,Rattus norvegicus,Homo sapiens,Pseudomonas aeruginosa)
• Eukaryotic DNA mismatch repair (MMR) (, NA)
• Nephronophthisis: Disease Mechanisms of a Ciliopathy (, NA)
• Nephronophthisis: Disease Mechanisms of a Ciliopathy (, NA)
• Nephronophthisis: Disease Mechanisms of a Ciliopathy (, NA)
• Mechanism of resistance and SCC development (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Canis lupus familiaris,Lareunionomyces loeiensis,Murine sarcoma virus 3611)
• Coordination of DNA Single Strand Break Repair (, NA)
• p38 signaling to the chromatin in muscle progenitor cells (, NA)
• Hypothesized regulation of the different routes of Ca2+ influx and/or release from stores by NTs, and its effects on intracellular Ca2+ levels (, Rattus norvegicus,Homo sapiens)
• S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• BDNF/TrkB signaling convergence on the MAP kinase pathway is implicated in both synaptic plasticity and learning and memory (, NA)
• Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras (, NA)
• Main pathways altered in GEMMs of cutaneous melanoma (, Rat sarcoma virus,Avian leukosis virus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Correlates of metastatic melanoma response to checkpoint inhibition (, NA)
• Correlates of metastatic melanoma response to checkpoint inhibition (, NA)
• AMP-Activated Protein Kinase – A Ubiquitous Signalling Pathway with Key Roles in the Cardiovascular System (, NA)
• AMP-Activated Protein Kinase – A Ubiquitous Signalling Pathway with Key Roles in the Cardiovascular System (, NA)
• Oncogenic growth factor signaling mediating tumor escape from cellular immunity (, NA)
• Brain foods: the effects of nutrients on brain function (, Saccharomyces cerevisiae,Solanum tuberosum,Arachis hypogaea,Curcuma longa,Helianthus annuus,Spinacia oleracea,Theobroma cacao,Ginkgo biloba,Linum usitatissimum,Prunus dulcis,Persea americana,Lens culinaris,Bertholletia excelsa,Homo sapiens,Pan troglodytes,Pan troglodytes schweinfurthii,Mus musculus,Rattus norvegicus,Gallus gallus,Meleagris gallopavo,Bos taurus)
• Tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (, NA)
• Anoikis signaling pathway in cancer cells (, Human gammaherpesvirus 4,Equine rhinitis A virus,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• MATI/III and GNMT control DNA synthesis and hepatocyte growth (, NA)
• The Akt/mTOR pathway in tobacco-carcinogen induced lung tumorigenesis (, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Panax ginseng,Homo sapiens)
• Cross-talk between TCR and TGFB signaling networks (, NA)
• Biochemical pathway of junction remodeling at the BTB, apical ES and hemidesmosome (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Syringa vulgaris,Homo sapiens,Drosophila melanogaster,Canis lupus familiaris,Merluccius merluccius)
• Core components of the MAPK signaling pathway (, NA)
• Cadmium-induced Testicular Injury (, NA)
• Schema of proposed clodronate signaling pathway (, NA)
• Regulation of muscle growth and regeneration by the immune system (, NA)
• Clostridium difficile infection (, Escherichia coli,Staphylococcus aureus,Bacillus subtilis,Clostridioides difficile,Enterococcus faecalis,Bacillus subtilis At2,Bacillus anthracis,Escherichia coli IS1,Clostridium perfringens,Klebsiella oxytoca,Clostridioides difficile 630,Paeniclostridium sordellii,Mus musculus,Oryctolagus cuniculus,Sus scrofa,Cricetus cricetus,Enterovirus C,Sigma virus,Homo sapiens,Bacteriophage sp.)
• Scar-mediated inhibition and CSPG receptors in the CNS (, NA)
• Targeting iron metabolism in drug discovery and delivery (, Nicotiana tabacum,Matthiola incana,Artemisia annua,Mus musculus,Rattus norvegicus,Danio rerio,Mergus merganser,Homo sapiens,Caenorhabditis elegans,prion,Subgroup C,Staphylococcus capitis)
• Joubert syndrome: insights into brain development, cilium biology and complex disease (, NA)
• Schematic diagram summarizing alterations in molecules of the signalling pathway leading to protein synthesis in Lean and Obese Zucker rats after High force electrical stimulation (HFES) (, Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Candida dubliniensis,Homo sapiens,Oryctolagus cuniculus)
• ECM–cell communication is dictated by focal-adhesion players (, NA)
• ROS in Cancer: The Burning Question (, NA)
• NO/cGMP pathway is a signaling node for pro- and anti-angiogenic signaling (, NA)
• Thrombospondin-1 (TSP1) binds to two receptors on endothelial cells that inhibit NO signaling (, NA)
• VEGF binding to VEGFR2 on endothelial cells activates its Tyr kinase activity and results in autophosphorylation of the receptor at several cytoplasmic sites (, NA)
• Metabolic shifts in hypoxia: the role of Hif1 and miR-210 in reductive stress (, NA)
• “Tissue Development, Cardiovascular System Development and Function, Organismal Development.” This was the top most associated network according to IPA core analysis of the TM gene input set which included the microarray study by Fan et al (, NA)
• Melanocyte activation integrated in the schematic view of the UV-induced pigmentation pathway in the normal skin (, NA)
• Melanocyte differentiation (, NA)
• Autophagy in UV damage response (, Homo sapiens,Mus musculus,Human papillomavirus,Azumapecten farreri)
• Strategies for Increasing Pancreatic Tumor Immunogenicity (, Listeria monocytogenes,Porphyromonas gingivalis,Bacteroides fragilis,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,human oral metagenome)
• Targets for lithium’s neuroprotective effects (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Human immunodeficiency virus,Alburnus alburnus)
• Multiple pro-inflammatory mediators in the tumor microenvironment increase the accumulation of MDS cells and enhance their immunosuppressive activity (, Homo sapiens,Mus musculus)
• Disrupting the Rb-Raf-1 Interaction: A potential therapeutic target for cancer (, NA)
• Cholesterol and isoprenoid synthesis pathway which shows the inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase by statins (, NA)
• Adipose Tissue NAD+ Biology in Obesity and Insulin Resistance: From Mechanism to Therapy (, Homo sapiens,Mus musculus,Helianthus tuberosus,Dendrothereua homa)
• Tuberous sclerosis complex and mTOR pathway (, NA)
• Stress-induced EGF Receptor Signaling Through STAT3 and Tumor Progression in Triple-Negative Breast Cancer (, NA)
• Intestinal FXR and TGR5 signaling in metabolic regulation (, NA)
• Canonical cannabinoid receptor (CBR)-mediated, G protein-dependent signaling pathways (, NA)
• The Role of Neutrophils in the Event of Intestinal Inflammation (, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Shigella flexneri,Helicobacter pullorum,Mus musculus,Rattus norvegicus,Homo sapiens)
• Based on GeneCodis3 analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, 23 significantly enriched pathways were revealed (, NA)
• Pathway alterations diagram integrating gene mutations and copy number alterations to identify pathways altered in UC- and CD-associated CAC (, Homo sapiens,Mus musculus)
• Gestational exposure to sidestream (secondhand) cigarette smoke promotes transgenerational epigenetic transmission of exacerbated allergic asthma and bronchopulmonary dysplasia (, NA)
• Oxysterols in human cancer (, NA)
• Promising bone-related targets for rheumatoid arthritis therapy (, NA)
• Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy (, Homo sapiens)
• Insulin-dependent signal transduction pathways (, NA)
• Conserved insulin-signaling pathway in the ovary (, NA)
• Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway (, NA)
• Targeting the cyclin D–cyclin-dependent kinase (CDK)4/6–retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions (, NA)
• The expression of cell cycle regulatory genes modulated by P (, Pleurotus ostreatus,Homo sapiens)
• Targeting the Transforming Growth FactorB Signaling Pathway in Human Cancer (, NA)
• Regulation of nitric oxide signaling by thrombospondin-1: implications for anti-angiogenic therapies (, Mus musculus,Rattus norvegicus,Mouse mammary tumor virus,Polyomavirus sp.,Homo sapiens,Candida dubliniensis)
• Models of Merlin-dependent membrane receptor distribution in flies and mammalian cells (, Drosophila melanogaster,Caenorhabditis elegans,Monosiga brevicollis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Endotoxin binds to CD14 and Toll-like receptor 4 (TLR4) on the surface of monocytes and endothelial cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,unidentified influenza virus,clinical samples,Mycobacterium tuberculosis variant bovis BCG)
• Schematic presentation of the signaling pathway for LPS-induced PI3K/PKCD-dependent CHL1 expression in cultured astrocytes from early postnatal mouse cerebral cortex (, NA)
• Summary of ergot-alkaloid biosynthetic pathways with emphasis on Clavicipitaceae (, NA)
• B2-agonists (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Tumor-Associated Macrophages as Treatment Targets in Oncology (, Homo sapiens,Mus musculus,unidentified)
• Emerging Role of MicroRNAs in mTOR Signaling (, Homo sapiens,Mus musculus,Human betaherpesvirus 5,Punica granatum)
• Emerging Role of MicroRNAs in mTOR Signaling (, Homo sapiens,Mus musculus,Human betaherpesvirus 5,Punica granatum)
• Emerging Role of MicroRNAs in mTOR Signaling (, Homo sapiens,Mus musculus,Human betaherpesvirus 5,Punica granatum)
• Emerging Role of MicroRNAs in mTOR Signaling (, Homo sapiens,Mus musculus,Human betaherpesvirus 5,Punica granatum)
• Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition (, NA)
• What’s the buzz about hydroxynorketamine? Is it the history, the story, the debate, or the promise?! (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cannabinoid receptor-dependent mechanisms whereby AEA leads to tumor growth suppression and/or cell death (, NA)
• Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases (, NA)
• Heme synthethic pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus)
• Cancer metabolism as a central driving force of glioma pathogenesis (, Homo sapiens)
• IRF4: Immunity. Malignancy! Therapy? (, Human gammaherpesvirus 4,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,unidentified)
• Apoptosis in cerebral ischemia and reperfusion (, NA)
• ROS are associated with the generation of CIN (, Mus musculus,Cricetulus griseus,Homo sapiens,Saccharomyces cerevisiae)
• Viral infection elicits a variety of antiviral cellular responses (, Human alphaherpesvirus 1,Vesicular stomatitis virus,Vaccinia virus,Measles morbillivirus,Human alphaherpesvirus 2,Reovirus sp.,Myxoma virus,Homo sapiens,Rattus norvegicus,Candida dubliniensis,Equus caballus,Marinobacter nauticus,NA)
• Shear stress regulates the activity of NFKB (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,Human immunodeficiency virus)
• Possible cross-talk between Nod2, TCR, Cd28, TLR and TNFR family members in regulating NFKB (, NA)
• Canonical Notch Signaling Pathway: Structural And Biochemical Insights Into Shape, Sugar, And Force (, NA)
• Schema of major signaling pathways involved in renal development (for space and clarity, not all factors in each pathway shown) (, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Homo sapiens)
• Stem cell models in the colon (, NA)
• Gene selection in the TGFß signaling pathway (, Homo sapiens,Mus musculus,Canis lupus familiaris)
• Novel Strategies for Reversing Platinum Resistance (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Signaling and regulation of PRR-induced autophagy (, NA)
• Haploinsufficient tumor suppressor genes (, NA)
• Haploinsufficient tumor suppressor genes (, NA)
• Interactions of IGF and ERB signaling pathways in malignancy (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Overlap of the present results with Greengard’s neurotransmission integration scheme (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway (, NA)
• Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation (, Homo sapiens,Mus musculus)
• Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle (, NA)
• Proteins that interact directly or indirectly with mGlu1/5 receptors and mediate receptor signalling (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Curious origins of Angioimmunoblastic T-Cell Lymphoma (, NA)
• RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Moloney murine leukemia virus)
• mTOR-signaling pathway: mTORC1 and mTORC2 complexes and the key signaling nodes that regulate mTORC1 and mTORC2 (, Mus musculus,Rattus norvegicus,Graphiurus murinus,Drosophila melanogaster,Cerobasis alpha,Homo sapiens,Saccharomyces cerevisiae,Streptomyces hygroscopicus)
• Signaling pathways that lead from activated KIT and aggregated FcERI to mast cell responses (, NA)
• Alterations in mTOR signaling pathway on spermatogenesis (, Mus musculus,Rattus norvegicus,Graphiurus murinus,Drosophila melanogaster,Cerobasis alpha,Homo sapiens,Saccharomyces cerevisiae,Streptomyces hygroscopicus)
• Simplified representation of the complement cascade (, NA)
• Roles of mTOR signaling pathway in cancer in type 2 diabetes (, Mus musculus,Rattus norvegicus,Homo sapiens)
• TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice (, NA)
• Roles of Autophagy signaling pathway in cancer in type 2 diabetes (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Extracellular nutrients are required to maintain oncogenic signaling in brain cancer – a critical role for mTORC2 (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• KEGG MAPK signaling pathway (KEGG ID: hs04010) (, NA)
• Proposed mechanism for the action of 7,8-dihydroxyflavone (7,8-DHF) on enhancing the outcome of exercise post-TBI (, NA)
• Working model of PKA’s role in trastuzumab resistance (, NA)
• Molecular mechanisms of dietary fat absorption within enterocytes (, NA)
• Inflammasome complexes: emerging mechanisms and effector functions (, Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Escherichia coli DH5alpha,Clostridioides difficile,Shigella flexneri,Legionella pneumophila,Clostridioides difficile CD3,Streptococcus sp. group B,Francisella tularensis subsp. novicida,Clostridioides difficile CD8,Homo sapiens,Mus musculus)
• Pancreatic Islet Inflammation: An Emerging Role for Chemokines (, NA)
• TGFB signaling pathway (, NA)
• Metabolic and epigenetic coordination of T cell and Macrophage immunity (, Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Mus musculus,Influenza A virus)
• Metabolic and epigenetic coordination of T cell and Macrophage immunity (, Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Mus musculus,Influenza A virus)
• Metabolic reprogramming and tolerance during sepsis-induced AKI (, NA)
• Metabolic reprogramming and tolerance during sepsis-induced AKI (, NA)
• Panel A shows cGMP-dependent and independent nitric oxide (NO) signaling pathways (, Oryctolagus cuniculus,Canis lupus familiaris,Mustela putorius furo,Lepus timidus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Panax ginseng,Sturnus vulgaris)
• Topology of leukemia-related BCR-ABL pathway (, Homo sapiens,Saccharomyces cerevisiae)
• Tired hippocampus: The molecular impact of sleep deprivation on hippocampal function (, NA)
• How is the Brain Renin-Angiotensin System Regulated? (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Adeno-associated virus)
• Proposed mechanistic model as to how ciRS-7 functions as a miR-7 sponge and regulates EGFR/RAF1/MAPK pathway via inhibiting miR-7 activity (, NA)
• Biologic and Clinical Perspectives on Thyroid Cancer (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Biologic and Clinical Perspectives on Thyroid Cancer (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks (, Mus musculus,Cavia porcellus,Homo sapiens,Drosophila melanogaster)
• Barcoding of GPCR Trafficking and Signaling Through the Various Trafficking Roadmaps by Compartmentalized Signaling Networks (, Mus musculus,Cavia porcellus,Homo sapiens,Drosophila melanogaster)
• Cellular signaling pathways and transcriptional regulatory circuits mediating physiologic cardiac hypertrophic growth (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Sturnus vulgaris)
• Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis (, NA)
• Notch signaling in the mammalian ovary (, NA)
• Complementopathies (, Homo sapiens,Escherichia coli)
• KEAP1-NRF2 Signaling and Autophagy in Protection against Oxidative and Reductive Proteotoxicity (, Mus musculus,Rattus norvegicus,Homo sapiens)
• KEAP1-NRF2 Signaling and Autophagy in Protection against Oxidative and Reductive Proteotoxicity (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Response of heterogeneous ribonuclear proteins (hnRNP) to ionizing radiation and their involvement in DNA damage repair (, NA)
• Response of heterogeneous ribonuclear proteins (hnRNP) to ionizing radiation and their involvement in DNA damage repair (, NA)
• CanProVar 2.0: an Updated Database of Human Cancer Proteome Variation (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells (, NA)
• Putative targets of common changes in gene expression with single and repeated IMO stress (, NA)
• FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states (, NA)
• Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? (, NA)
• Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? (, NA)
• Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? (, NA)
• mTOR Signaling Cascade (, Homo sapiens,Mus musculus)
• Proteomics analyses of prostate cancer cells reveals cellular pathways associated with androgen resistance (, Homo sapiens,Bos taurus)
• Downregulation of several proteins in the oxidative phosphorylation pathway identified in the global proteomic data for LNCaP-95 androgen resistant prostate cancer cells (, Homo sapiens,Bos taurus)
• Examination of Tetrahydrobiopterin Pathway Genes in Autism (, Homo sapiens)
• NPM-ALK oncogenic tyrosine kinase controls T cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells (, NA)
• Proposed model of the underlying mechanism by which NeuroD6 may bridge neuronal differentiation to survival (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Unaspis yanonensis,Homo sapiens,Armoracia rusticana,Xenopus laevis)
• Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin (, NA)
• Failure of Mitochondria Leads to Neurodegeneration: Do Mitochondria Need A Jump Start? (, NA)
• Estrogen synthesis and aromatase promoter II use in the ovary (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Mouse mammary tumor virus)
• Identification of Actively Translated mRNA Transcripts in a Rat Model of Early Stage Colon Carcinogenesis (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Oryctolagus cuniculus,Zea mays)
• TRAIL-R1/-R2 apoptotic signaling pathway (, Oryctolagus cuniculus,Canis lupus familiaris,Mycobacterium tuberculosis variant bovis BCG,Mycobacterium tuberculosis variant bovis,Homo sapiens,Mus musculus)
• miRNA process pathway (, NA)
• Road to the crossroads of life and death: Linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer (, NA)
• Mitotic removal of cohesin in humans: In humans, cohesins (pink) are removed from chromosome arms in prophase in a Plk1-dependent pathway (, NA)
• Wnt signaling and senescence: a tug of war in early neoplasia? (, Mouse mammary tumor virus,Human papillomavirus type 16,Betapolyomavirus macacae,Mus musculus,Rattus norvegicus,Homo sapiens)
• Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy (, Saccharomyces cerevisiae,Nicotiana tabacum,Syzygium aromaticum,Mus musculus,Cricetus cricetus,Homo sapiens,Escherichia coli)
• Impaired DNA Damage Response – an Achilles’ Heel Sensitizing Cancer to Chemotherapy and Radiotherapy (, Saccharomyces cerevisiae,Nicotiana tabacum,Syzygium aromaticum,Mus musculus,Cricetus cricetus,Homo sapiens,Escherichia coli)
• Nuclear Receptor Coregulators in Cancer Biology (, NA)
• “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia (, NA)
• Kidney development: from ureteric bud formation to branching morphogenesis (, NA)
• Activation of aromatase promoter I.4 and promoters I.3/II in breast adipose fibroblasts and promoter I.7 in breast endothelial cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Mouse mammary tumor virus)
• EGFR signaling through the PI3K/Akt pathway (, NA)
• Cell cycle and acute kidney injury (, NA)
• Is cancer a disease of abnormal cellular metabolism? (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Differentiating Human Multipotent Mesenchymal Stromal Cells Regulate microRNAs (, Homo sapiens,Mus musculus,Bos taurus,Danio rerio,Matthiola incana,Human papillomavirus type 16)
• Multiple regulatory loops exist within the EGF signaling cascade (, NA)
• Cytokine signaling modules in inflammatory responses (, NA)
• Different views of the Akt pathway/network (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Schizosaccharomyces pombe,Homo sapiens,Mus musculus)
• COPPER ACTIVATION OF NFKB SIGNALING IN HEPG2 CELLS (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Cinnamomum verum,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• CREB-induced IL-10 production is regulated by IFNG (, Mycobacterium tuberculosis,Bacillus anthracis,Mycobacterium tuberculosis SP1,Mycobacterium tuberculosis SP3,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida albicans,Homo sapiens,Human immunodeficiency virus 1)
• Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function (, NA)
• Aging is a complicated process, often characterized by increased ROS and inflammation (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Altered B cell signalling in autoimmunity (, Homo sapiens,Mus musculus,Middle East respiratory syndrome-related coronavirus)
• Key components of the stress response signaling network in C (, NA)
• PD-1 is also expressed on T-cells following TCR engagement and activation (, Helicobacter pylori,Human gammaherpesvirus 4,Human papillomavirus,Anaplasma marginale,Homo sapiens,Mus musculus,Nicotiana tabacum,gut metagenome)
• Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia (, NA)
• Pathological pain and the neuroimmune interface (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human alphaherpesvirus 3,Homo sapiens,Staphylococcus aureus)
• Oncogene-induced genomic instability (, Homo sapiens,Mus musculus,Iris germanica)
• Mitotic chromosomal instability and cancer: mouse modelling of the human disease (, Mouse mammary tumor virus,Betapolyomavirus macacae,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,prion,Nymphalis l-album)
• “Pushmi-Pullyu” of DNA REPAIR: Clinical Synthetic Lethality (, Homo sapiens,Drosophila melanogaster,Iris germanica,Rupicapra rupicapra)
• Mechanistic association of insulin signaling with mitochondrial function in normal and diabetic brain (, Corvus corax,Corvus corax PS-1,Corvus corax PS-2,Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular Modeling in the Age of Clinical Genomics, The Enterprise of the Next Generation (, NA)
• A, Multifactorial etiology of adhesion formation (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Rattus norvegicus)
• Beclin 1-Independent Pathway of Damage-Induced Mitophagy and Autophagic Stress: Implications for Neurodegeneration and Cell Death (, NA)
• Model describing the regulation of protein synthesis by AMPK, Ca++ and Akt -signaling pathways (, NA)
• The diversity and plasticity of adult hepatic progenitor cells and their niche (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Skin microbiome and mast cells (, NA)
• Roles of the selected genes in the DSBR pathway (, NA)
• Sepsis and septic shock (, Homo sapiens)
• Apoptotic signaling in aging muscles (, NA)
• Shh pathway targets and regulatory networks (, NA)
• Recurrent architecture of tumour initiation, progression and drug sensitivity (, NA)
• Comparison of Biomarker Expression between Proximal and Distal Colorectal Adenomas: The Tennessee-Indiana Adenoma Recurrence Study (, NA)
• REV1 and DNA polymerase zeta in DNA interstrand crosslink repair (, NA)
• BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure (, NA)
• Reactivation of the p90RSK–CDC25C pathway leads to bypass of the ganetespib induced G2/M arrest and mediates acquired resistance to ganetespib in KRAS mutant NSCLC (, NA)
• Calcium signaling pathway initiated by melanoma contact to endothelium (, NA)
• Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis (, NA)
• Identification of the serine biosynthesis pathway as a critical component of BRAF inhibitor resistance of melanoma, pancreatic, and non-small cell lung cancer cells (, NA)
• mTORC1 signaling and the metabolic control of cell growth (, NA)
• NMR-Based Stable Isotope Resolved Metabolomics in Systems Biochemistry (, NA)
• A, Schematic diagram showing intra-cellular functions of the Bcl family of proteins (, NA)
• Hyperglycemia-Induced Tau Cleavage In Vitro And In Vivo: A Possible Link Between Diabetes And Alzheimer’s Disease (, Mus musculus,Rattus norvegicus,Armoracia rusticana,Bikinia letestui,Homo sapiens,Capra hircus)
• PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Oxygen Availability and Metabolic Adaptations (, NA)
• AKT/PKB Signaling: Navigating the Network (, Homo sapiens,Mus musculus)
• AKT/PKB Signaling: Navigating the Network (, Homo sapiens,Mus musculus)
• Integration of activated transcription factors with the upstream signaling network during CB1R-induced neurite outgrowth (, NA)
• Proposed model for I-SMAD-regulated signaling that enhances HSPG expression, cholesterol uptake and HCV entry (, NA)
• Schematic diagram depicting the signalling pathways linking insulin-RBM20-titin splicing (, NA)
• The PI3K-AKT-mTOR signaling pathway (, Mus musculus,Rattus norvegicus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Syzygium aromaticum)
• Reelin-LIS1-tubulins pathway (, Mus musculus,Rattus norvegicus,Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Syzygium aromaticum)
• Heterogeneous ribosomes preferentially translate distinct subpools of mRNAs genome-wide (, Saccharomyces cerevisiae,Armoracia rusticana,Kluyveromyces lactis,Crateva religiosa,Vesicular stomatitis virus,Encephalomyocarditis virus,Cricket paralysis virus,Homo sapiens,Mus musculus,Escherichia coli,Drosophila melanogaster,Oryctolagus cuniculus,NA)
• Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R (, Mus musculus,Homo sapiens)
• Proposed scheme of steroid-regulated cancer progression via Shc proteins (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape (, Saccharomyces cerevisiae,Drosophila melanogaster,Lareunionomyces loeiensis,Antarctothoa delta,Homo sapiens,Mus musculus,NA)
• Biological determinants of radioresistance and their remediation in pancreatic cancer (, NA)
• Emerging role of PI3K/AKT-mediated epigenetic regulation in cancer (, NA)
• Emerging role of PI3K/AKT-mediated epigenetic regulation in cancer (, NA)
• PLCG1 deficiency perturbs phosphorylation on canonical TCR signaling proteins (, NA)
• Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity (, NA)
• Revisiting the Role of Wnt/Beta-catenin Signaling in Prostate Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• TGFB family member signaling and its target in CRC (, NA)
• Proposed model of the Src/IGF-IR signaling axis present in both prostate cancer Exo and cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• DGAT1-dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy (, Saccharomyces cerevisiae,Bos taurus,Oryctolagus cuniculus,Saccharomyces cerevisiae CAT-1,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• INTERLINKING INTERLEUKIN-7 (, NA)
• Cofilin Mediates LPS-Induced Microglial Cell Activation and Associated Neurotoxicity Through Activation of NFKB and JAK-STAT Pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli IS25,Homo sapiens,Armoracia rusticana,Xenopus laevis)
• Negative regulators of the RIG-I-like receptor signaling pathway (, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Vesicular stomatitis virus,Encephalomyocarditis virus,H3N2 subtype,Homo sapiens,Mus musculus,Cerobasis alpha,NA,NA,NA)
• Negative regulators of the RIG-I-like receptor signaling pathway (, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Vesicular stomatitis virus,Encephalomyocarditis virus,H3N2 subtype,Homo sapiens,Mus musculus,Cerobasis alpha,NA,NA,NA)
• Negative regulators of the RIG-I-like receptor signaling pathway (, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Vesicular stomatitis virus,Encephalomyocarditis virus,H3N2 subtype,Homo sapiens,Mus musculus,Cerobasis alpha,NA,NA,NA)
• Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors (, NA)
• Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors (, NA)
• Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products (, Serratia marcescens)
• Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products (, Serratia marcescens)
• RAS Proteins and Their Regulators in Human Disease (, NA)
• Metabolic Disorder Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,NA)
• Insulin-induced PI3K-Akt and MAPK network in hepatocytes (, NA)
• Model depicting the Cdc42-mediated regulation of EGF receptor interactions with c-Cbl (, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Sus scrofa,Meleagris gallopavo)
• The main cellular mechanisms of chemioresistance (, NA)
• Targeting mTOR in fibrosis (, NA)
• Control of B Lymphocyte Development and Functions by the mTOR Signaling Pathways (, NA)
• The role of mTORC1 signaling in suppression of lipolysis in adipocytes (, Bos taurus,Oryctolagus cuniculus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• To identify coherent networks of genes influenced directly by smoking, we examined the potential interconnections of the 310 genes identified in the genome wide methylation analysis using PPI information in the STRING database (, NA)
• Innate Immunity to Intracellular pathogens: balancing microbial elimination and inflammation (, NA)
• Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Anti-Angiogenesis (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Gallus gallus,Human immunodeficiency virus 1)
• IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway (, NA)
• Genomics, Biology, and Human Illness: Advances in the Monogenic Autoinflammatory Diseases (, Homo sapiens,Mus musculus,Danio rerio,Clostridium botulinum,Canna indica)
• Up and down-regulated metabolic proteins in PANC-1 cells (, NA)
• DNA damage and its links to neurodegeneration (, NA)
• IRE1A arm of the unfolded protein response (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida dubliniensis,Human gammaherpesvirus 8,Coxsackievirus B3,Homo sapiens,prion,bacterium C-10)
• Oxidative Stress and Obesity, Diabetes, Smoking, and Pollution: Part 3 of a 3-Part Series (, Nicotiana tabacum,Candida dubliniensis,Olea europaea,Theobroma cacao,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens)
• Antiviral mechanisms in mammalian cells: IFN-based antiviral system, including IFN expression pathway (AE) and IFN response pathway (AR); the intrinsic antiviral pathway (B); and the RNAi antiviral pathway (C) (, Human alphaherpesvirus 1,West Nile virus,Betapolyomavirus macacae,Encephalomyocarditis virus,Chikungunya virus,Nodamura virus,Homo sapiens,Mus musculus,Caenorhabditis elegans,synthetic RNA,NA,NA)
• miRNA pathways in myeloid differentiation and myeloid-derived malignancies (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Vesicular stomatitis virus)
• miRNA pathways in mature immune cell function (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Vesicular stomatitis virus)
• Action of PD-1 and CTLA-4 pathway inhibitors (, Homo sapiens,Mus musculus)
• Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Methionine metabolic pathway (, NA)
• Dox- and AD198-induced apoptosis and chemosensitization by inhibition of the PI3K/AKT pathway with LY294002 in OSCCs in vitro (, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Felis catus,Homo sapiens,Nicotiana tabacum,Human papillomavirus)
• Inherited and Acquired Disorders of Magnesium Homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Key components of the JAK/STAT pathway (, NA)
• An overview of central carbon metabolism (, NA)
• Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Insulin and the PI3K/AKT Signaling Pathway Regulate Ribonuclease 7 Expression in the Human Urinary Tract (, Escherichia coli,Pseudomonas aeruginosa,Escherichia coli K-12,Citrobacter rodentium,Escherichia coli CFT073,Escherichia coli UTI89,Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,clinical samples)
• Ten Strategies of Interferon Evasion by Viruses (, NA)
• Schematic summary of the possible link between IGF-1R signaling, synaptic changes, neurotransmitter function and inflammatory response (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cavia porcellus,Homo sapiens)
• Innate immune escape by Dengue and West Nile viruses (, West Nile virus,Dengue virus,Zika virus,Japanese encephalitis virus,Kunjin virus,West Nile virus strain NY-99,tick-borne encephalitis virus group,Aedes aegypti,Aedes albopictus,Homo sapiens,Mus musculus,NA)
• Fanconi Anemia Protein Interaction Network: Casting A Wide Net (, Homo sapiens)
• Post-translational Modifications (PTMs) that Modulate the Retinoic Acid-Inducible Gene I (RIG-I)-like receptor (RLR)–Mitochondrial Antiviral Signaling Protein (MAVS) Signaling Pathway (, NA)
• SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling (, Homo sapiens,Mus musculus)
• Working Title: Who is the real 12-HETrE? (, NA)
• Entanglement of GSK-3B, Beta-catenin and TGFB1 signaling network to regulate myocardial fibrosis (, NA)
• Molecular actions of HDIs in sarcoma (, NA)
• Toll gates to periodontal host modulation and vaccine therapy (, NA)
• Ras-ERK/MAPK signaling-associated stem cell regulators (, Caenorhabditis elegans,Kurzia media,Perionyx excavatus,Escherichia coli,Escherichia coli OP50,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Configuring a robust nervous system with Fat cadherins (, Gallus gallus,Danio rerio,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Echinochloa frumentacea)
• Clarifying Busulfan Metabolism and Drug Interactions to Support New Therapeutic Drug Monitoring Strategies: A Comprehensive Review (, Homo sapiens)
• BCR–ABL pathway drives signaling in H929 cells and phosphorylation is inhibited by imatinib (, Homo sapiens,Oryctolagus cuniculus)
• Metabolic Abnormalities and Oxidative Stress in Lupus (, Homo sapiens,Mus musculus,NA)
• Regulation of Wnt Signaling by Protocadherins (, Gallus gallus,Danio rerio,Xenopus laevis,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Substituting SNORD115 with an oligonucleotide (, Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Canis lupus familiaris,Equus caballus,Escherichia coli IS1,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Xenopus laevis)
• TLR Mediated Immune Responses in the Urinary Tract (, NA)
• Processing and digestion of engulfed apoptotic cells utilizes LC3-associated phagocytosis and promotes an anti-inflammatory response (, Saccharomyces cerevisiae,Candida dubliniensis,Aspergillus fumigatus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a “Watch-and-Wait” Approach to Cancer (, NA)
• InterferonA Negatively Regulates the Expression of Endothelial Nitric Oxide Synthase and Nitric Oxide Production: Implications for SLE (, Homo sapiens,Mus musculus,Capra hircus)
• Action of metformin on cancer (, NA)
• The STAT3 pathway and therapeutic targets (, NA)
• Possible interactions between PVN inflammation and sympathoexcitation in spontaneously hypertensive rats (, NA)
• MUC1-C IS A TARGET IN LENALIDOMIDE RESISTANT MULTIPLE MYELOMA (, NA)
• Summary diagram depicting the current understanding of GRK3 regulation and function in the cardiovascular and respiratory systems (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster,Danio rerio,Human gammaherpesvirus 8)
• Targeting of protein translation as a new treatment paradigm for prostate cancer (, Homo sapiens,Mus musculus)
• TLR Mediated Immune Responses in the Urinary Tract (, NA)
• TLR Mediated Immune Responses in the Urinary Tract (, NA)
• PI3K/AKT/mTOR pathway and interaction with PTEN and TSC1/TSC2 (, Mus musculus,Rattus norvegicus,Homo sapiens)
• The MUST complex (MAGEL2-USP7-TRIM27) is important for the retromer-mediated endosomal protein recycling pathway (, Eutheria,Metatheria,Ornithorhynchus anatinus,Gallus gallus,Danio rerio,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Dendritic cells (DC) can either activate adaptive immunity or tolerize T cells depending on their state of maturation (, NA)
• Dopamine regulation of GABAA receptors contributes to light/dark modulation of the ON-cone bipolar cell receptive field surround in the retina (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Carassius auratus,catfish,Necturus maculosus,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Arachis hypogaea,Homo sapiens,Byasa polyeuctes)
• Systemic lupus erythematosus (SLE)-activated platelets induce endothelial cell activation via an interleukin-1B (IL-1B) pathway (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• The major pathways involved in excitation-contraction, and relaxation coupling in GI smooth muscle (, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Felis catus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Gallus gallus,Diaporthe sclerotioides)
• HSC Niche Biology and HSC Expansion Ex Vivo (, Danio rerio,Phoenicopterus roseus,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Preventive effect of rapamycin on hsBAFF-evoked B-cell proliferation and survival (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Escherichia coli,Human gammaherpesvirus 4)
• Schematic diagram for molecular mechanisms of activation of ER stress (, NA)
• Stat1 signaling pathway and modulation by T (, NA)
• Linking long non-coding RNA to control bile acid signaling and cholestatic liver fibrosis (, Homo sapiens,Mus musculus)
• Regulated Cell Death Pathways (, NA)
• AT1 receptor signaling pathways in the cardiovascular system (, NA)
• AT1 receptor signaling pathways in the cardiovascular system (, NA)
• Proteome Profile of Functional Mitochondria from Human Skeletal Muscle Using One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS (, Armoracia rusticana,Diaporthe sclerotioides,Vasconcellea candicans,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,NA)
• Osteopontin expression is a specific outcome of alternate pathway signalling (, NA)
• IL-4 induces an alternate pathway for BCR signalling (, NA)
• Puzzles, promises and a cure for ageing (, NA)
• Specification of cell fate in the mammalian cochlea (, NA)
• Borrelia burgdorferi infection induces lipid mediator production during Lyme arthritis (, Mus musculus,Rattus norvegicus,Homo sapiens,Borreliella burgdorferi)
• Enzymatic oxylipin synthesis pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Scomberomorus regalis)
• Landscape of new drugs in lymphoma (, NA)
• Landscape of new drugs in lymphoma (, NA)
• AMPK-activating drugs that reduce cellular ATP levels, such as the antidiabetic metformin, promote tumor suppressive actions in a LKB1-dependent manner (, NA)
• Synthesis and turnover of complex sphingolipids along with actin dynamics are regulated by PI4,5P2 and the Slm1 and Slm2 proteins (, NA)
• Multiple and bidirectional connections between actin dynamics and endocytosis (, NA)
• Transcriptional programs controlling endocytosis and genetic reprogramming by endocytosis (, NA)
• Endocytic circuitries in asymmetric cell division (, NA)
• Representative intracellular g-protein coupled signal transduction cascades (, Homo sapiens)
• Genetic and epigenetic mechanisms of gene regulation during lens development (, NA)
• Genetic and epigenetic mechanisms of gene regulation during lens development (, NA)
• Signal transduction pathways involved in Ha-ras-mediated AEG-1 induction (, NA)
• Neurotransmitter receptor heteromers and their integrative role in ‘local modules’: The striatal spine module (, NA)
• ALTERNATE ROUTES FOR DRUG DELIVERY TO THE CELL INTERIOR (, NA)
• ALTERNATE ROUTES FOR DRUG DELIVERY TO THE CELL INTERIOR (, NA)
• Wnt signaling pathways (, NA)
• Schematic view of the VEGFvascular endothelial growth factor pathway and the sites of action of its inhibitors (, Homo sapiens)
• Diagram shows a simplified scheme of the phosphatidylinositol 3-kinase (PI3K)/Akt/mTORmammalian target of rapamycin signaling pathway (, Homo sapiens)
• TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated with Hyperlipidemia (, NA)
• Central tolerance for B cells (, Saccharomyces cerevisiae,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Galatella linosyris,Homo sapiens,Mus musculus,Gallus gallus,Equus caballus)
• Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis (, NA)
• NOD1 and NOD2: beyond peptidoglycan sensing (, Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Shigella flexneri,Brucella abortus,Chlamydia muridarum,Candidatus Sodalis pierantonius str. SOPE,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Human betaherpesvirus 5,Vesicular stomatitis virus,ssRNA viruses,Drosophila melanogaster,Plasmodium falciparum,Trypanosoma cruzi,Plasmodium berghei,Homo sapiens,Mus musculus,Oryza sativa,NA)
• NOD1 and NOD2: beyond peptidoglycan sensing (, Brucella abortus,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Enterococcus faecalis,Shigella flexneri,Chlamydia muridarum,Candidatus Sodalis pierantonius str. SOPE,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Human betaherpesvirus 5,Vesicular stomatitis virus,ssRNA viruses,Drosophila melanogaster,Plasmodium falciparum,Trypanosoma cruzi,Plasmodium berghei,Homo sapiens,Mus musculus,Oryza sativa,NA)
• Innate and Adaptive Immune Responses in Chronic HCV infection (, NA)
• ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES (, Influenza A virus,unidentified influenza virus,Dengue virus,Zika virus,West Nile virus,Japanese encephalitis virus,Yellow fever virus,Dengue virus type 2,Influenza A virus H3N2,Tick-borne encephalitis virus,Kunjin virus,Tick-borne flavivirus,Langat virus,West Nile virus strain NY-99,Yellow fever virus 17D,Spondweni virus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• ANTAGONISM OF TYPE I INTERFERON BY FLAVIVIRUSES (, Influenza A virus,unidentified influenza virus,Dengue virus,Zika virus,West Nile virus,Japanese encephalitis virus,Yellow fever virus,Dengue virus type 2,Influenza A virus H3N2,Tick-borne encephalitis virus,Kunjin virus,Tick-borne flavivirus,Langat virus,West Nile virus strain NY-99,Yellow fever virus 17D,Spondweni virus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines (, NA)
• Protein-bound uremic toxins could take use of five potential toxin-conjugated albumin-receptor pathways to either promote or suppress inflammation (, NA)
• Signaling and gene regulatory networks in mammalian lens development (, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Oryzias latipes,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Signaling and gene regulatory networks in mammalian lens development (, Gallus gallus,Danio rerio,Xenopus laevis,Coturnix coturnix,Oryzias latipes,Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Crosstalk between Panx1 and ligand-gated receptor channels (, Mus musculus,Rattus norvegicus,Xenopus laevis,Paralichthys olivaceus,Homo sapiens,Olea europaea)
• Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells (, NA)
• Transcriptional regulation of Th9 cell generation (, NA)
• The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (, NA)
• JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (, NA)
• The role of the TGF-Beta-Smad and BMP-Smad signaling pathways in myocardial infarction and the mechanisms of some associated potential therapies (, Sophora flavescens,Styphnolobium japonicum,Euonymus japonicus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Xenopus laevis)
• Mechanism of synergistic action of VCN-2 and docetaxel (DTL) (, NA)
• Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer (, NA)
• Metabolic regulation of the immune humoral response (, NA)
• Thyroid C-Cell Biology and Oncogenic Transformation (, Homo sapiens)
• Thyroid C-Cell Biology and Oncogenic Transformation (, Homo sapiens)
• Proposed model (, NA)
• Model of the role of FAK in regulating lineage commitment, proliferation, and osteogenic differentiation of BMSCs (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Armoracia rusticana,Diaporthe sclerotioides,Homo sapiens,Xenopus laevis)
• Hippo pathway in intestinal regeneration and disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,Hepatitis B virus,NA)
• Hippo pathway in intestinal regeneration and disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,Hepatitis B virus,NA)
• Hippo pathway in intestinal regeneration and disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,Hepatitis B virus,NA)
• Hippo pathway in intestinal regeneration and disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Lareunionomyces loeiensis,Hepatitis B virus,NA)
• Association between expression of cell cycle proteins in NETs according to pathway (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Citrus macrophylla)
• Hypothetical roles of ANTXR1 as a modulator of HbF expression (, Homo sapiens,Papio hamadryas,Papio anubis,Diaporthe sclerotioides,Senegalia senegal,Mus musculus,Bacillus anthracis)
• Metabolic Instruction of Immunity (, NA)
• Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors (, NA)
• Nuclear receptors outside the nucleus: extranuclear signalling by steroid receptors (, NA)
• T Cell Signaling and Gene Regulation Defects in Systemic Lupus Erythematosus (SLE) (, Homo sapiens,Mus musculus,Adeno-associated virus,Patella vulgata)
• Immune mediators in the brain and peripheral tissues in autism spectrum disorder (, Homo sapiens,Macaca mulatta,Bacteroides fragilis,Candidatus Arthromitus sp. SFB-mouse,Mus musculus,Danio rerio,gut metagenome)
• Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications (, Homo sapiens,Mus musculus)
• Etiology and Management of Muscle Wasting in Chronic Liver Disease (, NA)
• Apoptosis and necroptosis as host defense strategies to prevent viral infection (, NA)
• Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus (, NA)
• Progesterone Receptors (PR) Mediate STAT Actions: PR and Prolactin Receptor Signaling Crosstalk in Breast Cancer Models (, NA)
• Mapping Biological Networks from Quantitative Data-Independent Acquisition Mass Spectrometry Proteomic Data: Data to Knowledge Pipelines (, Arabidopsis thaliana,Malus domestica,Agriosomyces longus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pathway enrichment analysis of primary human lung cell secretory proteins with decreased abundance in response to PC (, Mus musculus,Rattus norvegicus,Homo sapiens,Agriosomyces longus)
• Action of Targeted Therapies in Metastatic Renal Cell Carcinoma (, Homo sapiens,Mus musculus,Bikinia letestui,synthetic RNA)
• Role of Ras pathway proteins in exo-some biogenesis, cargo selection and release (, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 4,Plasmid pTF1)
• Structural variability in the RLR-MAVS pathway and sensitive detection of viral RNAs (, NA)
• pRB/E2F pathway dysregulation leading to unrestricted CASP3 gene transcription (, NA)
• Activation of PC-3 by PAC-1 and its derivatives via chelation of labile inhibitory zinc (, NA)
• Towards precision oncology in advanced prostate cancer (, Homo sapiens,Mus musculus,NA)
• Towards precision oncology in advanced prostate cancer (, Homo sapiens,Mus musculus,NA)
• Towards precision oncology in advanced prostate cancer (, Homo sapiens,Mus musculus,NA)
• Biology of Forgetting – A Perspective (, NA)
• Towards precision oncology in advanced prostate cancer (, Homo sapiens,Mus musculus,NA)
• Death receptor signaling in the heart: cell survival, apoptosis, and necroptosis (, Mus musculus,Homo sapiens)
• Towards precision oncology in advanced prostate cancer (, Homo sapiens,Mus musculus,NA)
• Pictorial representation of the signaling pathway activated by VLA-5 binding to fibronectin (, NA)
• NAD+ biosynthetic and degradative enzymes (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular mechanisms of arrhythmogenic cardiomyopathy (, NA)
• Dysregulation of the complement cascade in C3 glomerulopathy (, Homo sapiens,Mus musculus,Sus scrofa,Bikinia letestui,Sugarcane Ramu stunt disease phytoplasma)
• Splicing the innate immune signalling in leukaemia (, Homo sapiens)
• Scheme of the N-linked glycosylation pathway (, Homo sapiens,Bikinia letestui)
• The suppressive effects of Crabp1 in adipogenesis and adipocyte hypertrophy (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Simian endogenous retrovirus)
• Responsive Drosophila intestinal stem cell lineage (, Drosophila,Homo sapiens)
• Gluconeogenesis in cancer cells – repurposing of a starvation-induced metabolic pathway? (, NA)
• Regulatory network hubs are related to neurogenesis (, NA)
• Tumor-targeting bacteria engineered to fight cancer (, Escherichia coli,Staphylococcus aureus,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Escherichia coli K-12,Salmonella enterica,Mycobacterium tuberculosis variant bovis BCG,Streptococcus pyogenes,Mycobacterium tuberculosis variant bovis,Clostridium acetobutylicum,Bifidobacterium longum,Salmonella enterica subsp. enterica serovar Typhi,Streptococcus sp. group A,Clostridium butyricum,Aliivibrio fischeri,Bifidobacterium longum subsp. infantis,Clostridium acetobutylicum ATCC 824,Vibrio vulnificus,Escherichia coli Nissle 1917,Clostridium sporogenes,Clostridium tetani,Clostridium novyi NT,Clostridium novyi,Salmonella enterica subsp. enterica serovar Gallinarum,Human papillomavirus,Human papillomavirus type 16,Vaccinia virus,Enterovirus C,Measles morbillivirus,Mus musculus,Rattus norvegicus,unidentified shuttle vector,synthetic gene,Homo sapiens,Canis lupus familiaris,transposons,Sinsheimervirus phiX174)
• Pathway to chronic rapamycin therapy in prostate cancerModel: Chronic mTORC1 inhibition delays of PCa progression from active surveillance (, unidentified influenza virus,Vaccinia virus,Homo sapiens,Mus musculus)
• Roles of microglia/macrophages in tumor progression of brain cancer and metastatic disease (, NA)
• PTEN controls the G2-M transition to prevent bypass of the G2 checkpoints and premature entry into mitosis (M) (, NA)
• MicroRNA Mediated Regulation of Immunity against Gram-Negative Bacteria (, NA)
• DNA damage response pathway (, NA)
• Tetherin blocks virus release, activates an innate immune response and is counteracted by Vpu or Nef (, Homo sapiens,Human immunodeficiency virus 1,Human immunodeficiency virus,Macaca mulatta,Pan troglodytes,Chlorocebus aethiops,Simian immunodeficiency virus,Ebola virus sp.,Human immunodeficiency virus 2,Cercocebus atys,Equine infectious anemia virus,Cercopithecidae,Avian retroviruses,Cercopithecus mona,Mus musculus,Escherichia coli)
• Possible mechanisms of inhibition of receptor tyrosine kinases by EGCG (, NA)
• Review of Markers of Zona Glomerulosa and Aldosterone-Producing Adenoma Cells (, NA)
• Stretch-induced actomyosin contraction in epithelial tubes: mechanotransduction pathways for tubular homeostasis (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Spiroplasma phage R8A2B)
• Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases (, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Cytotoxic Vibrio T3SS1 Rewires Host Gene Expression to Subvert Cell Death Signaling and Activate Cell Survival Networks (, Escherichia coli,Pseudomonas aeruginosa,Helicobacter pylori,Vibrio parahaemolyticus,Clostridium botulinum,Vibrio vulnificus,Helicobacter pylori SS1,Bos taurus,Oryctolagus cuniculus,Equus asinus,Saccharomyces cerevisiae,Sequoia sempervirens,Homo sapiens,Mus musculus,uncultured marine bacterium)
• Mitochondrial Ribosomes in Cancer (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Vasconcellea candicans,Mesocricetus auratus,Escherichia coli,Chlamydia psittaci,Homo sapiens,Bos taurus,Gallus gallus,Euparyphium melis)
• Schematic representation of the mTOR signaling pathway before discovery of TSC function (, NA)
• RNA editing-dependent epitranscriptome diversity in cancer stem cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Human alphaherpesvirus 1,NA)
• Protein O-GlcNAcylation: emerging mechanisms and functions (, NA)
• microRNAs and lipid metabolism (, NA)
• Gemfibrozil, stretching arms beyond lipid lowering (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Human immunodeficiency virus 1,NA)
• Neural Stem Cell-based Regenerative Approaches for the Treatment of Multiple Sclerosis (, NA)
• Endocannabinoid System in Neurodegenerative Disorders (, NA)
• Endocannabinoid System in Neurodegenerative Disorders (, NA)
• Endocannabinoid System in Neurodegenerative Disorders (, NA)
• Development of POMC neurons (, NA)
• Mixed Chimerism-Based Transplant Tolerance (, Homo sapiens,Macaca fascicularis,Mus musculus,Sus scrofa,Listeria monocytogenes)
• Damage Associated Molecular Patterns in the Pathogenesis of Osteoarthritis: Potentially Novel Therapeutic Targets (, NA)
• Proposed model of pleiotropic roles of Ca+2/calmodulin-dependent (CAMK) pathways regulating cadmium toxicity in human osteoblast-like cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Aeromonas hydrophila)
• Cell-autonomous excitation of midbrain dopamine neurons by endocannabinoid-dependent lipid signaling (, Mus musculus,Rattus norvegicus,Cavia porcellus,Diaporthe sclerotioides,Allium tricoccum,Homo sapiens,Bos taurus)
• Apoptosis in animal models of virus-induced disease (, NA)
• Diagrammatic representation of hypothesized molecular mechanism of LH signaling dysfunction in PCOS women modified from (, Homo sapiens,Macaca mulatta,Macaca fascicularis,Mus musculus,Rattus norvegicus,Ovis aries)
• Overall pathway of DC Activation (, NA)
• General signaling cascades responsible for downstream activation of TLRs (, NA)
• Network of selected factors influencing myofibroblast survival/resistance to apoptosis (, NA)
• Protective role of autophagy pathway in AD pathogenesis (, NA)
• Protective role of the FOXO pathway in aging and AD pathogenesis (, NA)
• The IR/Akt/mTOR signaling pathway in promoting aging and AD pathogenesis (, NA)
• Protective role of the SIRT pathway in aging and AD pathogenesis (, NA)
• Controversial role of the hypoxia/HIF signaling pathway in aging and AD pathogenesis (, NA)
• Illustration shows a simplified scheme of the BRAF/MEK/ERK signaling pathway (, NA)
• The ROS pathway in aging and AD pathogenesis (, NA)
• Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP2) Signaling in Immune Cell Functions (, NA)
• Synaptic Long-Term Potentiation: Genes differentially expressed in the NAC of LE vs (, Rattus norvegicus,Homo sapiens)
• Dopamine Receptor Signaling: Genes differentially expressed in the NAC of LE vs (, Rattus norvegicus,Homo sapiens)
• Protective role of the AMPK pathway in aging and AD pathogenesis (, NA)
• Significantly Mutated Genes and Regulatory Pathways in SCLC – A Meta-analysis (, NA)
• Schematics representing different tissues using varied forms of cellular communication within a lineage hierarchy (solid arrows indicate cell lineages; dotted arrows represent signaling between different cells) (, Homo sapiens,Drosophila melanogaster)
• Dual role of pro-inflammatory cytokines in regulating synaptic plasticity (, NA)
• Ethanol upregulates TNFA in Kupffle cells via the activation of multiple pathways Ethanol administration activates the TLR4 pathway, ROS production and complement activation to increase the expression of TNFA (, NA)
• Cell biology of APOL1 (, Trypanosoma brucei,Trypanosoma brucei gambiense,Trypanosoma brucei rhodesiense,Botrynema brucei,Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Human immunodeficiency virus 1,Vibrio cholerae)
• Matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1 (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Candida dubliniensis,Homo sapiens)
• Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia (, NA)
• Targeting EGFR resistance networks in Head and Neck Cancer (, Homo sapiens,Mus musculus,Nicotiana tabacum,Human papillomavirus,Corynebacterium phage gamma)
• ER stress-induced signaling pathways that mediate autophagy (, Mus musculus,Saccharomyces cerevisiae,Homo sapiens)
• Glia unglued: How signals from the extracellular matrix regulate the development of myelinating glia (, NA)
• Nitric oxide - the forgotten child of tumor metabolism (, NA)
• Molecular mechanisms determining lifespan in short- and long-lived species (, Bos taurus,Canis lupus familiaris,Delphinus delphis,Loxodonta africana,Balaena mysticetus,Balaenoptera acutorostrata,Pteropus alecto,Myotis davidii,Myotis brandtii,Mus musculus,Rattus norvegicus,Heterocephalus glaber,Cryptomys hottentotus,Drosophila melanogaster,Caenorhabditis elegans,Arctica islandica,Homo sapiens,Pan troglodytes,Saccharomyces cerevisiae,Betapolyomavirus macacae,NA)
• Stromal niche for epithelial stem cells: a template for regeneration and a brake on malignancy (, NA)
• JARID1 Histone Demethylases: Emerging Targets in Cancer (, NA)
• Tissue force programs cell fate and tumor aggression (, NA)
• Liver Kinase B1 Links Macrophage Metabolism Sensing and Atherosclerosis (, NA)
• Trafficking of Heme and Porphyrins in Metazoa (, NA)
• PID gene defects in the IFNG pathway (, NA)
• Complex Roles of mTOR in Adipocytes and Beyond (, NA)
• Loss of NLRX1 exacerbates neural tissue damage and NFKB Signaling following brain injury (, Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus,unidentified influenza virus,clinical samples,Melia azedarach)
• NMD degrades mRNAs encoding UPR components (, NA)
• NMD and apoptosis have a complex regulatory relationship I (, NA)
• Diagram showing LMP1 signaling transduction to IRF4 activation (, NA)
• MAIT conundrum – how human MAIT cells distinguish bacterial colonization from infection in mucosal barrier tissues (, Homo sapiens)
• Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (, NA)
• Summary of pathways and signals discussed in this review that induce NK cell activation and/or NKG2D ligand expression in tumor cells and in virus-infected cells (, Human immunodeficiency virus 1,Human immunodeficiency virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Murid betaherpesvirus 1,Abelson murine leukemia virus,Homo sapiens,Mus musculus,NA)
• Mitochondrion: a central architect of copper homeostasis (, NA)
• Glycerolipid biosynthetic pathway enzyme localization to subcellular compartments (, NA)
• From phenologs to silent suppressors: Identifying potential therapeutic targets for human disease (, Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Adeno-associated virus)
• RPL23 links oncogenic RAS signaling to p53-mediated tumor suppression (, NA)
• Rationale for mTOR inhibitor + NOTCH inhibitor combination (, NA)
• Role of Cross Talk between PI3-Kinase and ERK/MAP Kinase Pathways in Artery-Vein Specification (, NA)
• Possible mechanism by which BMPs and estrogen regulate GNRH production by GT1-7 cells (, NA)
• Lymphocyte Fate and Metabolism: A Clonal Balancing Act (, NA)
• Rethinking HSF1 in stress, development and organismal health (, NA)
• Biosynthesis and Structure-Activity Relationships of the Lipid A Family of Glycolipids (, Escherichia coli,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica,Porphyromonas gingivalis,Campylobacter jejuni,Chlamydia trachomatis,Cereibacter sphaeroides,Neisseria meningitidis,Francisella tularensis,Bacteroides thetaiotaomicron,Francisella tularensis subsp. novicida,Rhizobium leguminosarum,Bordetella pertussis,Leptospira interrogans,Salmonella enterica subsp. enterica serovar Minnesota,Pseudomonas aeruginosa BL10,Capnocytophaga canimorsus,Hepatitis B virus,Human papillomavirus,Homo sapiens,Mus musculus,Drosophila melanogaster,Triportheus paranensis)
• Genetic Basis for Kidney Cancer (, NA)
• Intracellular ascorbate (Asc) modulates redox-sensitive signaling pathways in microvascular endothelial cells during sepsis (, Bos taurus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli)
• Signaling pathways downstream of HVEM, LIGHT, and their binding partners are shown (, NA)
• Signalling crosstalk in B cells: managing worth and need (, Mus musculus,Homo sapiens)
• Proposed schematic of Akt pathway control in the UMSCC47, UPCI-SCC90, and the SQ20B cell lines (, NA)
• Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling, Loss of Lens Specific Markers, and Changes in Stress Response Proteins (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Signaling molecules and pathways regulating the fate of spermatogonial stem cells (, NA)
• AROMATASE EXCESS IN CANCERS OF BREAST, ENDOMETRIUM AND OVARY (, NA)
• Biosynthesis of Polyketide Synthase Extender Units (, NA)
• Roles of ectonucleotidases in sequential activation of purinergic receptors (, NA)
• Working model of the mechanical response pathway by which pressure and shear stimulate tumor cell adhesion (, Homo sapiens,Mus musculus,Cyprinus carpio)
• Schematic diagram depicting the mechanism of PTxB-mediated desensitization of CXCR4 (, NA)
• AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease (, Mus musculus,Rattus norvegicus,Sus scrofa,Sus scrofa domesticus,Homo sapiens,Saccharomyces cerevisiae,NA)
• Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires Barrestin-2 (, NA)
• Immunobiology of the IL-15-IL-15RA Complex as an Antitumor and Antiviral Agent (, Human alphaherpesvirus 1,Human immunodeficiency virus,Adeno-associated virus,Simian immunodeficiency virus,Myxoma virus,Mus musculus,Rattus norvegicus,Homo sapiens,Mycobacterium tuberculosis variant bovis BCG,Bacillus phage Gamma)
• Psoriasis: A mixed autoimmune and autoinflammatory disease (, Homo sapiens)
• Activity-Dependent BDNF Release is Required for the Rapid Antidepressant Actions of Scopolamine (, Mus musculus,Rattus norvegicus,Homo sapiens,adeno-associated virus 2,Merluccius merluccius)
• Red Carpet for Iron Metabolism (, Xanthorhoe munitata)
• Strategy for analysis of ERBB2-driven gastric cancer (, NA)
• ERBB signaling pathway analysis (, NA)
• Summation of the proteomic values for the ERBB2− sample set for genes present in the regulation of actin cytoskeleton pathway for ERBB2− set from KEGG (, NA)
• Novel Mechanisms and Functions of Complement (, NA)
• Strategies for Comparing Metabolic Profiles: Implications for the Inference of Biochemical Mechanisms from Metabolomics Data (, Homo sapiens,Diaporthe sclerotioides)
• Pathway alterations in glioblastoma multiforme (, NA)
• Eosinophil chemoattractant 5-oxo-ETE and the OXE receptor (, NA)
• Nox proteins in signal transduction (, NA)
• Metabolic Advantages and Vulnerabilities in Brain Metastases (, NA)
• Nutrient regulation of pancreatic Beta-cell proliferation (, NA)
• Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses (, NA)
• Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses (, NA)
• Nutrient regulation of pancreatic Beta-cell proliferation (, NA)
• Model illustrating the intracellular signaling pathway leading to cell proliferation and survival in response to NRG-1B treatment (, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Fibroblast Growth Factor Receptor Signaling Pathway as a Mediator of Intrinsic Resistance to EGFR-specific Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• The Fibroblast Growth Factor Receptor Signaling Pathway in Non-Small Cell Lung Cancer (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• P53 pathway (, NA)
• Epidermal growth factor receptor (EGFR) pathway (, NA)
• Hypoxia signaling pathway in DM patients 4d post-CPB/C (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• PCP and SHH Signaling pathways (, NA)
• Mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain (, NA)
• G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Molva molva,Corynephage beta)
• The Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Ligation of HLA class I molecules by anti-HLA antibodies activates signaling cascades that result in EC survival and proliferation (, NA)
• The cellular mechanisms in endothelial cells mediating the antiangiogenic and capillary barrier actions of 2-ME (, NA)
• Pathway for activation of Ca cycling proteins in cardiac myocytes during Beta-adrenergic stimulation (, Mus musculus,Rattus norvegicus,Cavia porcellus,Oryctolagus cuniculus,Mustela putorius furo,Homo sapiens,Xenopus laevis)
• PI3K pathway in human disease (, Homo sapiens)
• PI3K pathway in human disease (, Homo sapiens)
• PI3K pathway in human disease (, Homo sapiens)
• Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase CD, Lyn Kinase, and Matrix Metalloproteinases (, Homo sapiens)
• PI3K pathway in human disease (, Homo sapiens)
• Toward better understanding of the mechanism of this hydroarylation reaction, the kinetic isotope effect studies were performed (, NA)
• PIK3CA cellular signaling pathway (, Homo sapiens)
• New concepts in herpes simplex virus vaccine development: notes from the battlefield (, NA)
• MELK promotes melanoma growth by stimulating the NFKB pathway (, NA)
• Proposed model for the integration of anti-proliferative genomic and nongenomic 1,25D pathways via MAPK cross-talk through a classic VDR in human osteosarcoma cells (, Homo sapiens)
• Representation of NF1 interactions with the Ras and PI3K pathways (, Homo sapiens,Mus musculus)
• Brothers and Sisters: Molecular insights into arterial-venous heterogeneity (, Gallus gallus,Danio rerio,Coturnix coturnix,Mus musculus,Rattus norvegicus,Homo sapiens,Paraechinus aethiopicus)
• MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• MELK promotes melanoma growth by stimulating the NFKB pathway (, NA)
• Cyclin–CDK complexes and the cyclin D–CDK4/6–p16–Rb pathway in the cell cycleThe cell cycle is regulated by cyclins and checkpoints, with different cyclins (and cyclin–CDK combinations) and checkpoints acting at phase transition of the cell cycle (, NA)
• Interferon signaling in HPV-containing keratinocytes (, NA)
• Survival signals generated by PI3K and PLD that target mTOR (, NA)
• Found in translation: how preclinical research is guiding the clinical development of the BCL-2-selective inhibitor venetoclax (, NA)
• Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon like peptide-1 in the paraventricular hypothalamus (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Cricetulus griseus,Sindbis virus,Lyssavirus rabies,Suid alphaherpesvirus 1,Homo sapiens,Drosophila melanogaster,Gallus gallus,vectors)
• Integration of signaling changes after the induction of BP1 (, NA)
• Signalling mechanisms of syndecan heparan sulphate proteoglycans (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Human immunodeficiency virus 1)
• Schematic presentation of the proposed TGFB signaling alteration that promotes HNSCC in mice (, NA)
• An emerging role for the ribosome as a nexus for post-translational modifications (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Schizosaccharomyces pombe,Escherichia coli,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Deacetylases and NFKB in Redox Regulation of Cigarette Smoke induced Lung Inflammation: Implications in Pathogenesis of COPD (, NA)
• Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma (, Homo sapiens,Mus musculus)
• Targeting EGFR Co-dependent Signaling Pathways in Glioblastoma (, Homo sapiens,Mus musculus)
• Mechanisms regulating the duration of Erk (extracellular signal-regulated kinase) activation (, NA)
• An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: A biochemical and molecular perspective (, NA)
• P75NTR-mediated signal transduction pathways (, NA)
• PDGRF signaling pathway (, NA)
• Major components of FGF and HH signaling pathways (, NA)
• CHOLANGIOCYTE PRIMARY CILIUM IN HEALTH AND DISEASE (, NA)
• Interferon response genes are coordinately upregulated relative to the rs17445836 allele of IRF8 (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Innate immune evasion by hepatitis C virus and West Nile virus (, NA)
• Environment Matters: Microglia Function and Dysfunction in a Changing World (, NA)
• Inborn errors of immunity underlying fungal diseases in otherwise healthy individuals (, NA)
• Cholesterol transport in steroid biosynthesis: Role of protein-protein interactions and implications in disease states (, NA)
• Canonical PI3K signaling pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Avian retrovirus)
• Formation of autophagasomes in autophagy (, NA)
• Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity (, NA)
• Regulation of the Hippo pathway transcription factor TEAD (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Human papillomavirus type 16)
• Use of nuclear magnetic resonance-based metabolomics in detecting drug resistance in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans)
• Potential mechanisms of estrogen-mediated signaling through estrogen receptor (ESR) and G protein-coupled receptor 30 (GPR30) (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Homo sapiens,Diaporthe sclerotioides)
• CREB Mediates Prostaglandin F2Alpha-Induced MUC5AC Overexpression (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Cricetulus griseus,Homo sapiens,Armoracia rusticana)
• Trk receptor tyrosine kinases and major signal transduction pathways (, NA)
• Three main classes of regulatory small RNAs (, Drosophila melanogaster,Caenorhabditis elegans,Plasmodium falciparum,Bombyx mori,Aedes aegypti,Anopheles gambiae,Plasmodium berghei,Tribolium castaneum,Aedes albopictus,Acyrthosiphon pisum,Nilaparvata lugens,Culex quinquefasciatus,Plutella xylostella,Anopheles stephensi,Culex pipiens,Blattella germanica,Heliconius melpomene,Episyrphus balteatus,Megaselia abdita,Dengue virus,West Nile virus,Sindbis virus,Chikungunya virus,Dengue virus type 2,Semliki Forest virus,Rift Valley fever virus,dsRNA viruses,Flock House virus,La Crosse virus,mosquito-borne viruses,Yellow fever virus group,Wolbachia pipientis,Wolbachia sp. wMelPop,Homo sapiens,Mus musculus,Solanum melongena,NA)
• LKB1-AMPK pathway: metabolism and growth control in tumor suppression (, NA)
• LKB1-AMPK pathway: metabolism and growth control in tumor suppression (, NA)
• LKB1-AMPK pathway: metabolism and growth control in tumor suppression (, NA)
• Neuroprotective Effects of the Complement Terminal Pathway During Demyelination: Implications for Oligodendrocyte Survival (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Optic Pathway Gliomas in Neurofibromatosis Type 1 (, Homo sapiens,Mus musculus)
• Simplified schematic depicting the mTOR pathway and associated “mTORopathies.” The mTOR pathway involves 2 complexes, mTORC1 and mTORC2 (, Homo sapiens,Mus musculus)
• Regulation of aging: does autophagy underlie longevity? (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,AKT8 retrovirus)
• Parathyroid Hormone-related Protein Regulates Cell Survival Pathways via Integrin A6B4-mediated Activation of PI3-K/Akt Signaling (, Homo sapiens,Mus musculus,Bos taurus)
• Adiponectin-mediated regulation of inflammatory responses in different cell types (, NA)
• Expanding the Paradigm for the Outer Membrane: Acinetobacter baumannii in the Absence of Endotoxin (, NA)
• Trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line (, NA)
• CIE and CDE pathways showing lipid content and regulatory molecules (, NA)
• Transcriptional regulation of human CYP17 (, NA)
• Hepatitis B Virus Persistence (, NA)
• Metabolic Strategies of Melanoma Cells: Mechanisms, Interactions with the Tumor Microenvironment, and Therapeutic Implications (, NA)
• Apprehending multicellularity: regulatory networks, genomics and evolution (, NA)
• LPS signal transduction via the MyD88-independent pathway (, NA)
• LPS signal transduction via the MyD88-dependent pathway (, NA)
• Slingshot Family of Phosphatases Mediates Rac1 Regulation of Cofilin Phosphorylation, Laminin-332 Organization, and Motility Behavior of Keratinocytes (, NA)
• Hypothetical schematic of a DAergic synapse (, Mus musculus,Rattus norvegicus,Homo sapiens,Cannabis sativa)
• Transition to endocycles in Drosophila (, NA)
• Integration of ITAM and cytokine Jak–STAT signaling (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Evasion and subversion of antigen presentation by Mycobacterium tuberculosis (, NA)
• Plasma membrane damage activates the CWI pathway and the Ca2+-dependent signaling cascade in budding yeast.Purple circles indicate the components of the CWI pathway (, Homo sapiens,Saccharomyces cerevisiae)
• Working model of the plasma membrane damage checkpoint.The plasma membrane damage checkpoint activates the CWI pathway and the Ca2+-dependent signaling cascade (, Homo sapiens,Saccharomyces cerevisiae)
• Type I interferon production by dendritic cells in host defense (, NA)
• HYPOXIA AND PLACENTAL DEVELOPMENT (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Macaca mulatta,Diaporthe sclerotioides,Eutheria)
• Scheme for up-regulation of the PAI-1 gene by EGF in glioblastoma (, NA)
• Schematic presentation of different pathways involved in PCa disparity.1 (, NA)
• Controversy and Consensus: Non-Canonical Signaling Mechanisms in the Insect Olfactory System (, NA)
• Epithelial PGR regulates multiple signaling pathways in the endometrium and transuduce signals via uterine epithelial-stormal inteactions (, Bos taurus,Sus scrofa,Ovis aries,Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus)
• MOLECULAR CONSTITUTION OF BREAST BUT NOT OTHER REPRODUCTIVE TISSUES IS RICH IN GROWTH PROMOTING MOLECULES (, NA)
• Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets (, NA)
• Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets (, NA)
• Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease (, NA)
• Challenges and Promise of Targeting the Liver X Receptors for Treatment of Inflammatory Disease (, NA)
• ESTRADIOL MEMBRANE-INITIATED SIGNALING IN THE BRAIN MEDIATES REPRODUCTION (, NA)
• Akt-FoxO pathway in regulation of heart size (, NA)
• FoxO factors in endothelial cells (, NA)
• Diagrammatic representation of intracellular pathways of receptor-mediated endocytosis and trafficking: The ligand binding to specific cell surface receptor leads to a selective recruitment of ligand-receptor complexes into clathrin-coated pits (, NA)
• Pericytes of the neurovascular unit: Key functions and signaling pathways (, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Gallus gallus,Danio rerio,Human immunodeficiency virus 1,Human immunodeficiency virus,Felis catus,Homo sapiens,Candida dubliniensis,Antarctothoa delta)
• Pericytes of the neurovascular unit: Key functions and signaling pathways (, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Gallus gallus,Danio rerio,Human immunodeficiency virus 1,Human immunodeficiency virus,Felis catus,Homo sapiens,Candida dubliniensis,Antarctothoa delta)
• Pericytes of the neurovascular unit: Key functions and signaling pathways (, Mus musculus,Rattus norvegicus,Cavia porcellus,Bos taurus,Gallus gallus,Danio rerio,Human immunodeficiency virus 1,Human immunodeficiency virus,Felis catus,Homo sapiens,Candida dubliniensis,Antarctothoa delta)
• Wnt pathway can be classified as canonical and non-canonical (, NA)
• Canonical Wnt Pathway and Inhibitors of the Wnt/beta-Catenin Signaling Pathway (, NA)
• Non-Canonical Wnt Pathway and the Notch and Sonic Hedgehog Pathway-The two major non-canonical pathways are Wnt/calcium and Planar Cell Polarity (PCP) pathways (, NA)
• Cross-Talk between the Wnt, Notch and Sonic Hedgehog Pathways- Beta-catenin can drive activation of Notch signaling by increasing expression of the JAG1 gene, which encodes the Notch ligand Jagged1 (, NA)
• Coverage of the insulin receptor signaling pathway (, Mus musculus,Homo sapiens)
• Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target (, Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis)
• Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target (, Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis)
• Serotonin neuron development: shaping molecular and structural identities (, NA)
• Initiation of oocyte and follicular growth (, Bos taurus,Canis lupus familiaris,Ovis aries,Equus caballus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Gallus gallus)
• Flexible Roles for Proteoglycan Sulfation and Receptor Signaling (, NA)
• Sphingosine-1-phosphate synthesis and functions in mast cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Arachis hypogaea)
• Hypothetical diagram of possible sites of action of non-opioids in the regulatory pathway of MMPs (, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Human gammaherpesvirus 4)
• Hypothetical diagram of possible sites of action of non-opioids in the regulatory pathway of IL-6 (, Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Homo sapiens,Human gammaherpesvirus 4)
• Approaches to biomarkers in human colorectal cancer (, NA)
• Enzymatic pathways of the biosynthesis and degradation of the two main endocannabinoids, anandamide and 2-arachidonoylglycerol (, NA)
• Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas (, NA)
• Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development (, NA)
• Regulation of Granulosa and Theca Cell Transcriptomes During Ovarian Antral Follicle Development (, NA)
• GSH biosynthetic route and GSH cycle (, NA)
• Leptin signaling: A key pathway in immune responses (, NA)
• Monoclonal antibodies in the treatment of pancreatic cancer (, NA)
• MTDH/AEG-1 promotes tumor progression through the integration of multiple signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1)
• Apoptosis pathway (, Rattus norvegicus,Homo sapiens)
• Transcripts corresponding to most genes present in the KEGG Cell Cycle Pathway were increased in abundance in CCDs from rats on Day 2 of development of vasopressin-escape (, NA)
• Guardian of corpulence: a hypothesis on p53 signaling in the fat cell (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus,Human papillomavirus,Homo sapiens,NA)
• Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy (, NA)
• Pathway model for studying the influence of drug-binding kinetics on EGF signaling in non-small cell lung cancer (, NA)
• Schematic drawing showing the effects of IGF-1 and ALC on prepubertal Kp synthesis and release (, NA)
• Injury-induced changes in the nociceptive pathway (, Mus musculus,Rattus norvegicus,Castor fiber,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Homo sapiens,Danio rerio)
• Toll-like receptor (TLR) pathway (, Mus musculus,Rattus norvegicus,Castor fiber,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Homo sapiens,Danio rerio)
• Induction of autoimmunity by pristane and other naturally-occurring hydrocarbons (, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Helicobacter pylori,PX clade,Listeria monocytogenes,Homo sapiens,Salmo salar,Patella vulgata)
• Pathway from PI3K to TOR (, Rat sarcoma virus,Rous sarcoma virus,Avian sarcoma virus 16,UR2 sarcoma virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Gallus gallus)
• Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mTOR activity and p27Kip1 localization (, NA)
• Schematic depicting B2AR-mediated ERK activation (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Beta-catenin signaling and its regulation (, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Canis lupus familiaris,Xenopus laevis,Elephas maximus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Ethanol Preconditioning of Rat Cerebellar Cultures Targets Nmda Receptors to the Synapse and Enhances Peroxiredoxin 2 Expression (, NA)
• The role of adiponectin in blood pressure lowering (, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus)
• TumorMap framework and application to the analysis of the TCGA Pan-Cancer-12 Dataset (, NA)
• Activation of NFKB (nuclear factorKB) by canonical and atypical pathways (, NA)
• Regulation of Mitochondrial Respiratory Chain Biogenesis by Estrogens/Estrogen Receptors and Physiological, Pathological and Pharmacological Implications (, Homo sapiens)
• Toll-like receptors in skin infectious and inflammatory diseases (, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Porphyromonas gingivalis,Staphylococcus epidermidis,Mycobacterium leprae,Cutibacterium acnes,Leptospira interrogans,Cutibacterium acnes subsp. acnes,Treponema maltophilum,Saccharomyces cerevisiae,Candida albicans,unidentified influenza virus,Mouse mammary tumor virus,Vaccinia virus,Malassezia furfur,Drosophila melanogaster,Trypanosoma cruzi,Homo sapiens,Mus musculus)
• Air Pollution: Mechanisms of Neuroinflammation & CNS Disease (, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Equus caballus,Homo sapiens)
• Improved readability and performance with multi-scale information integrated in pathway visualization using metagraph (, NA)
• PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity dependent manner through a protein kinase C-dependent pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Lithobates catesbeianus)
• Mechanisms underlying the pleiotropic effects of statins in stroke (, Homo sapiens)
• Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents (, Lareunionomyces loeiensis,Veratrum californicum,Zingiber zerumbet,Physalis minima,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Gallus gallus,Danio rerio,Ovis aries,Paraechinus aethiopicus,Antarctothoa delta,Homo sapiens)
• mTORC1 signaling governs hematopoietic stem cell quiescence (, NA)
• Ras/mitogen-activated protein kinase (MAPK) signaling pathway and associated developmental syndromes (indicated by dashed lines) (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Panthera pardus)
• Simplified scheme depicting the basic signaling pathways defined in ischemic preconditioning in mammals (, Homo sapiens)
• Hedgehog signaling pathway (, Escherichia coli,Escherichia coli DH5alpha,Mycobacterium xenopi,Homo sapiens,Mus musculus,Armoracia rusticana)
• Non-canonical NFKB pathway in immunity and inflammation (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Saimiriine gammaherpesvirus 2,Ateline gammaherpesvirus 2,Helicobacter pylori,Citrobacter rodentium,Legionella pneumophila,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• Non-canonical NFKB pathway in immunity and inflammation (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Saimiriine gammaherpesvirus 2,Ateline gammaherpesvirus 2,Helicobacter pylori,Citrobacter rodentium,Legionella pneumophila,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• Key signaling pathways between amino acids, inflammatory cytokines, and tumor-specific factors gr1Amino acids stimulate muscle protein synthesis through the mTOR pathway (, Homo sapiens,Mus musculus)
• Non-canonical NFKB pathway in immunity and inflammation (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Saimiriine gammaherpesvirus 2,Ateline gammaherpesvirus 2,Helicobacter pylori,Citrobacter rodentium,Legionella pneumophila,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• Metabolic cooperativity between oocytes and cumulus cells, and the role of oocyte-derived paracrine factors in promoting metabolism in cumulus cells (, Xenopus laevis,Coturnix coturnix,Calyptocephallela gayi,Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Ovis aries,Macaca mulatta)
• Non-canonical NFKB pathway in immunity and inflammation (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Saimiriine gammaherpesvirus 2,Ateline gammaherpesvirus 2,Helicobacter pylori,Citrobacter rodentium,Legionella pneumophila,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• Interactions of Methoxyacetic Acid with Androgen Receptor (, Mus musculus,Homo sapiens)
• Non-canonical NFKB pathway in immunity and inflammation (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Saimiriine gammaherpesvirus 2,Ateline gammaherpesvirus 2,Helicobacter pylori,Citrobacter rodentium,Legionella pneumophila,Mus musculus,Rattus norvegicus,Homo sapiens,NA,NA)
• PI3K-AKT-mTOR signaling pathways in glioblastoma (, Mus musculus,Rattus norvegicus,Homo sapiens)
• How location governs Toll like receptor signaling (, NA)
• Inteferons pen the JAK-STAT pathway (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio,Ovis aries)
• Schematic showing the pathway for synthesis and mode of action of prostacyclin (PGI2) (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Siproeta stelenes)
• Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (, Saccharomyces cerevisiae,Phleum pratense,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,gut metagenome,Mouse mammary tumor virus)
• Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (, Saccharomyces cerevisiae,Phleum pratense,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,gut metagenome,Mouse mammary tumor virus)
• Cruciferous Vegetables and Human Cancer Risk (, NA)
• Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer's disease (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Cavia porcellus,Homo sapiens,Candida dubliniensis,Turdus migratorius)
• Genetic Susceptibility to Lupus: New Insights from fine mapping and genome-wide association studies (, Homo sapiens,Caenorhabditis elegans,Human gammaherpesvirus 4)
• Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer's disease (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Cavia porcellus,Homo sapiens,Candida dubliniensis,Turdus migratorius)
• Brucella abortus triggers a cGAS-independent STING pathway to induce host protection that involves guanylate-binding proteins and inflammasome activation (, Brucella abortus,Homo sapiens)
• Multiple isoforms catalyze each step in the glycerol-3-phosphate pathway of TAG synthesis (, NA)
• “Kinin danger signals proteolytically released by gingipain induce fimbriae-specific IFNG and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis” (, Porphyromonas gingivalis,Homo sapiens)
• IMP Dehydrogenase: Structure, Mechanism and Inhibition (, NA)
• Decoding the Epigenetic Language of Neuronal Plasticity (, NA)
• Autophagy pathway and machinery.A (, Human alphaherpesvirus 1,Sindbis virus,NA)
• Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase (, NA)
• Simplified model of the leptin signaling pathway (, Homo sapiens,Macaca mulatta,Callithrix jacchus,marmosets,Human adenovirus sp.,Human adenovirus 36,Human adenovirus 11p,Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Gallus gallus,Olea europaea)
• Transcriptional regulation of cytokine function in airway smooth muscle cells (, NA)
• Diagram shows the cell signaling pathways, which were involved in postconditioning (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Felis catus,Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Genetic Variation in TNF and the NFKB Canonical Pathway and Risk of Non-Hodgkin Lymphoma (, NA)
• Contribution of Rho to canonical Wnt3A signaling (, NA)
• Ubiquitin in NFKB Signaling (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Human T-cell leukemia virus type I,Cervus elaphus)
• Potential cascade of molecular events leading to reduced differentiation of regulatory T cells for prevention of autoimmunity (, Murid betaherpesvirus 1,Encephalomyocarditis virus,dsRNA viruses,Homo sapiens,Mus musculus)
• VEGF/VEGFR-mediated protection of cardiomyocytes from pressure stress and ischemia, and potential interactions of sunitinib and sorafenib (, NA)
• Carcinogenesis of Bcr-Abl in CML (, NA)
• HP1 Proteins Form Distinct Complexes and Mediate Heterochromatic Gene Silencing by Non-Overlapping Mechanisms (, NA)
• Deubiquitylation and regulation of the immune response (, Streptococcus pneumoniae,Haemophilus influenzae,Yersinia enterocolitica,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Generalized model for signaling through the NFKB pathway (, Homo sapiens,Saccharomyces cerevisiae)
• HiJAKing the Epigenome in Leukemia and Lymphoma (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• HiJAKing the Epigenome in Leukemia and Lymphoma (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pathway affected commonly in liver metastases irrespective of cancer types (, NA)
• Targeting the ASK1/MKK4/JNK pathway upstream of mitochondrial prodeath signaling (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of STAT3 signal transduction pathway (, NA)
• Bridging the gap between high-throughput genetic and transcriptional data reveals cellular pathways responding to alpha-synuclein toxicity (, Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Evolution of Fox genes and their role in development and disease (, NA)
• Novel Role of the Nociceptin System as a Regulator of Glutamate Transporter Expression in Developing Astrocytes (, NA)
• Outline of the major cell surface receptor-mediated signaling pathways important in the differentiation, survival, and function of melanocytes (, NA)
• Ligand binding to inactive monomeric Her receptors is followed by dimer formation and kinase activation (, NA)
• Ligand and receptor endocytosis in the Notch signaling pathway (, NA)
• TGFB can leave you breathless (, NA)
• Activation of inflammatory pathway mediated through NFKB by life-style related factors such as tobacco, stress, dietary agents, obesity, alcohol, infectious agents, irradiation and environmental stimuli that account for as much as 95% of all cancers (, Homo sapiens,Nicotiana tabacum)
• Proposed model of increase PTHrP expression in breast cancer cells (, NA)
• Nm23-H1suppression of tumor metastasis may depend on at least three pathways (, Human gammaherpesvirus 4,Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Adeno-associated virus,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Drosophila melanogaster,Arabidopsis thaliana)
• Scheme showing the role of different signaling pathways in mediating the effect of low K intake on ROMK and BK channels in the CCD (, NA)
• Scheme showing the role of different signaling pathways in mediating the effect of high K intake on ROMK and BK channels in the CCD (, NA)
• ES-EB system has made possible the identification of multipotent progenitors for both hemato-vascular and cardio-vascular derivatives (, Homo sapiens)
• Immunological synapse or the interface between an antigen presenting cell and a T-cell (, Homo sapiens)
• Is NFKB a good target for cancer therapy? Hopes and pitfalls (, NA)
• Wnt signaling network (, NA)
• Map of protein interactivity (binding, regulation, modification) between genes revealed to be significantly associated with bladder cancer in urothelial cell samples (, Homo sapiens,Nicotiana tabacum)
• How ERK1/2 Activation Controls Cell Proliferation and Cell Death Is Subcellular Localization the Answer? (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae,Cerobasis alpha)
• Schematic diagram depicting our findings on the post-transcriptional regulation of CXCR4 in MCF7-HER2 cells as a result of estrogen and HER2 cross-talk and the involvement of activated PI3K and MAPK pathways and TSC2 (tuberin) (, NA)
• Regulation of B-cell entry into the cell cycle (, NA)
• Genetic polymorphisms, their allele combinations and IFNB treatment response in Irish multiple sclerosis patients (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,NA)
• EGFR-dependent MAPK activation (, NA)
• Multiple previously established signaling cascades in activated mast cells with quantitative proteomic data from MCP5 cells represented as heatmap bars beside individual proteins (, Mus musculus,Homo sapiens)
• GD T cells in homeostasis and host defence of epithelial barrier tissues (, NA)
• Cancer cell metabolic changes linked to hyper-O-GlcNAcylation (, NA)
• Wnt/Beta-Catenin Signaling Acts at Multiple Developmental Stages to Promote Mammalian Cardiogenesis (, NA)
• Proposed coloboma mechanism in Lrp6-null eyes and a possible signaling network during early eye development (, NA)
• Quest for genetic determinants of human longevity: challenges and insights (, Homo sapiens)
• Retromer sorting pathway is made up of a coat complex that binds and transports transmembrane receptors between the endosome and the trans-Golgi network (TGN) (, NA)
• Intracellular signaling consequences of calpain-mediated substrate cleavage (, prion)
• Simplified EGFR signaling pathway (, NA)
• Oxygen Sensors and Modulators of Vascular Tone in Regions of Low PO2 in Erythrocytes (, NA)
• Regulation of IFN response genes by TLR3 signaling (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Renilla reniformis)
• Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage (, NA)
• Tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1 (, Saccharomyces cerevisiae,Gallus gallus,Xenopus laevis,Schizosaccharomyces pombe,Homo sapiens)
• Macrophage activation by endogenous danger signals (, NA)
• Wnt Signaling in Cardiovascular Disease: Opportunities and Challenges (, NA)
• Synaptically Localized Transcriptional Regulators in Memory Formation (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Controlling Hair Follicle Signaling Pathways through Polyubiquitination (, NA)
• Schema for the signaling pathway regulated by NHERF (, NA)
• Targeting lung inflammation: novel therapies for the treatment of COPD (, NA)
• BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells (, NA)
• Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer’s disease (, Candida dubliniensis,Colletotrichum paranaense,Homo sapiens,Mus musculus,prion)
• Regulation of hepatic glucose metabolism in health and disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Adeno-associated virus,NA)
• Type I Interferon signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryza sativa,Measles morbillivirus)
• Regulation of the immune response by the aryl hydrocarbon receptor (, Mycobacterium tuberculosis,Pseudomonas aeruginosa,Listeria monocytogenes,Streptococcus pneumoniae,Citrobacter rodentium,Limosilactobacillus reuteri,Mycobacterium tuberculosis PGG1,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Candida albicans,Influenza A virus,unidentified influenza virus,Homo sapiens,Danio rerio,Canis lupus familiaris)
• Proposed pathway involved in the regulation of the osteoblast F-actin cytoskeleton, based upon previous literature and the current experimental results (, NA)
• SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis (, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,vectors,clinical samples)
• The TSC/mTOR signaling pathway (, NA)
• Reactive Oxygen Species Damage Drives Cardiac and Mitochondrial Dysfunction Following Acute Nano-Titanium Dioxide Inhalation Exposure (, NA)
• Pathobiology of biliary epithelia (, NA)
• Downstream targets of IGF-1R (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,clinical samples)
• Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hexosamine Template – A Platform for Modulating Gene Expression and for Sugar-based Drug Discovery (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Triportheus paranensis)
• Hippo pathway, a vital growth regulator of cell proliferation and apoptosis was initially identified by mosaic screens in Drosophila melanogaster (,) (, Drosophila melanogaster,Homo sapiens)
• Viral infection of cells initiates the homo-dimerization and subsequent phosphorylation and activation of interferon-induced, double-stranded RNA-activated protein kinase (PKR) (, Adenoviridae,Human alphaherpesvirus 1,Vesicular stomatitis virus,Vaccinia virus,Measles morbillivirus,Reovirus sp.,Myxoma virus,Aurantiochytrium single-stranded RNA virus 01,Replication competent viruses,Human alphaherpesvirus 1 strain 17,Homo sapiens,Macaca mulatta,Aotus trivirgatus,Mus musculus,Rattus norvegicus,Escherichia coli,Marinobacter nauticus,Oryctolagus cuniculus,Diaporthe sclerotioides,NA,NA)
• Advances in Oncolytic Virus Therapy for Glioma (, Adenoviridae,Human alphaherpesvirus 1,Vesicular stomatitis virus,Vaccinia virus,Measles morbillivirus,Reovirus sp.,Myxoma virus,Aurantiochytrium single-stranded RNA virus 01,Replication competent viruses,Human alphaherpesvirus 1 strain 17,Homo sapiens,Macaca mulatta,Aotus trivirgatus,Mus musculus,Rattus norvegicus,Escherichia coli,Marinobacter nauticus,Oryctolagus cuniculus,Diaporthe sclerotioides,NA,NA)
• Proposed signaling pathway of mmLDL-induced, TLR4/Syk-dependent ROS generation and proinflammatory cytokine expression (, Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• Selective Raf Inhibition in Cancer Therapy (, NA)
• Selective Raf Inhibition in Cancer Therapy (, NA)
• GR signal transduction pathway (, NA)
• Paracrine and autocrine mechanisms of Akt-mediated tumor-stromal interactions (, Homo sapiens,Mus musculus)
• Notch and Kras in pancreatic cancer (, NA)
• Chemoattractant-guided walk through lymphopoiesis: from hematopoietic stem cells to mature B lymphocytes (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,NA)
• Bevacizumab-Induced Hypertension: Clinical Presentation and Molecular Understanding (, NA)
• Blocking the myostatin pathway (, NA)
• Activation of EP2 Prostanoid Receptors in Human Glial Cell Lines Stimulates the Secretion of BDNF (, NA)
• The concept of angiotensin II-growth factor cross-talk in ureteric bud morphogenesis (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Gene regulatory networks in kidney development (, NA)
• Activation of synaptic NMDAR mediates survival pathway and induces LTP and LTD (, Homo sapiens,Rattus norvegicus,Cordeauxia edulis)
• SST-induced hyperpolarization of subicular BCs (, NA)
• Effect of small DNA viruses on the ARF-p53 pathway (, Polyomavirus sp.,JC polyomavirus,Homo sapiens)
• mTOR signaling pathway (, Polyomavirus sp.,JC polyomavirus,Homo sapiens)
• Denosumab: Targeting the RANKL pathway to treat Rheumatoid Arthritis (, Homo sapiens,Mus musculus)
• One possible pathway which regulates cell migration in response to strain on fibronectin (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Sus scrofa)
• One possible pathway which regulates cell proliferation in response to strain on collagen (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Sus scrofa)
• Ingenuity Pathway network showing significant pathways (P-value ≤0.05) enriched by VvInt correlated transcripts (, NA)
• Recognition of poorly immunogenic tumor via endogenous and exogenous pathways (, NA)
• GRK4 pathway (, NA)
• Supreme EnLIGHTenment: Damage Recognition and Signaling in the Mammalian UV Response (, Homo sapiens,Dipturus trachyderma)
• Metabolic targeting strategies against malignant tumors that rely on HK-2 facilitated glycolytic flux (, Homo sapiens,Rattus norvegicus,Citrus x paradisi,NA)
• ICP10PK-mediated neuroprotection from MPP+-induced PCD (, NA)
• Major regulatory steps in the process of DNA damage response (DDR) (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster,Human immunodeficiency virus)
• Role of ATM in cellular responses (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster,Human immunodeficiency virus)
• Intracellular signaling resulting from activation of nAChRs, glutamate ionotropic receptors, and GABAA receptors (, Homo sapiens,Rattus norvegicus)
• MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway (, NA)
• Crz1 enters the nucleus in short stochastic bursts lasting about 2 min after undergoing dephosphorylation in the cytoplasm by the calcium-activated phosphatase calcineurin (Cn) (, ) (, NA)
• Essential kinase ATR: ensuring faithful duplication of a challenging genome (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Xenopus laevis)
• MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES (, Human immunodeficiency virus,unidentified influenza virus,Mouse mammary tumor virus,Respiratory syncytial virus,Vesicular stomatitis virus,Japanese encephalitis virus,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Candida dubliniensis,NA,NA)
• MICROBE SENSING, POSITIVE FEEDBACK LOOPS, AND THE PATHOGENESIS OF INFLAMMATORY DISEASES (, Human immunodeficiency virus,unidentified influenza virus,Mouse mammary tumor virus,Respiratory syncytial virus,Vesicular stomatitis virus,Japanese encephalitis virus,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Candida dubliniensis,NA,NA)
• TNF superfamily (, NA)
• Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways (, Saccharomyces cerevisiae,Arabidopsis thaliana,Triticum aestivum,Schizosaccharomyces pombe,Agaricus bisporus,Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Mus musculus,Escherichia coli,Gallus gallus,Danio rerio,Mycobacterium tuberculosis,Cricetulus griseus,Influenza B virus,Fowl aviadenovirus 1,Homo sapiens,Oryctolagus cuniculus)
• Independent of its source (endogenous/exogenous), 17Beta-estradiol protects the hippocampus against cerebral ischemia via activation of CREB pathway (, NA)
• Feedback inhibition of the phosphatidylinositol 3—kinase (PI3K) pathway (, Mouse mammary tumor virus,Rous sarcoma virus,Avian retrovirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,NA)
• Mechanistic model of enhanced activation induced by the E545K mutation in p110A (, Mouse mammary tumor virus,Rous sarcoma virus,Avian retrovirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,NA)
• Phosphatidylinositol 3—kinase (PI3K) signaling pathway (, Mouse mammary tumor virus,Rous sarcoma virus,Avian retrovirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,NA)
• Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an antagonist of class I phosphatidylinositol 3—kinase (PI3K) signaling (, Mouse mammary tumor virus,Rous sarcoma virus,Avian retrovirus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,NA)
• It’s all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection (, NA)
• Regulation of immunity and inflammation by hypoxia in immunological niches (, Pseudomonas aeruginosa,Helicobacter pylori,Clostridioides difficile,Clostridioides difficile CD8,Homo sapiens,Mus musculus)
• Wnt/Beta-catenin signaling in adipogenesis and metabolism (, NA)
• RNA Silencing (, Human immunodeficiency virus 1,Human immunodeficiency virus,unidentified influenza virus,Vesicular stomatitis virus,Hepatovirus A,Human spumaretrovirus,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Notch signaling in differentiation and function of dendritic cells (, Mus musculus,Homo sapiens)
• Proposed signaling pathway (, NA)
• Metabolic Regulation of Immune Responses (, Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus sp. group A,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• KEY ROLE OF EXTRACELLULAR VESICLES IN THE METASTATIC PROCESS (, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 4)
• Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio)
• Model of the role of MAPK cascades in cardiomyocyte hypertrophy (, NA)
• DNA Topoisomerase I Inhibitors: Chemistry, Biology and Interfacial Inhibition (, NA)
• Regulation of glycolysis, glutaminolysis and de novo nucleotide biosynthesis in tumor cells (, NA)
• Aberrant mTOR Signaling and Disrupted Autophagy: the Missing Link in Potential Vigabatrin-Associated Ocular Toxicity? (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Molecular changes from acute psychostimulant exposure to persistent molecular changes in the nucleus accumbens (NAc) and dorsal striatum (, NA)
• Regulation of L-type Ca2+ channel (LTCC) phosphorylation by psychostimulants (, NA)
• Molecular changes from acute to chronic amphetamine exposures in ventral tegmental area (VTA) dopaminergic (DA) neurons (, NA)
• Endoplasmic Reticulum and the Unfolded Protein Response (, Homo sapiens)
• Cardiac gene regulatory networks in Drosophila (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced Signal Transduction and Cell Proliferation in HCA-7 colon cancer cells (, NA)
• Castration-Adapted Prostate Cancer: Targeting Androgen Metabolic Pathways in Recurrent Disease (, Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Apoptotic pathway in Drosophila (, Homo sapiens,Mus musculus,Drosophila melanogaster,unidentified,Dipturus trachyderma)
• Protein kinase Cι: human oncogene, prognostic marker and therapeutic target (, Homo sapiens,Lambdavirus lambda)
• Major signaling pathways of cranial suture fusion (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Dermal cone/fat dome structure and its role in burn-related HTS pathogenesis (, NA)
• Beyond Alkylating Agents for Gliomas: Quo Vadimus? (, NA)
• Role of peroxisome-proliferator-activated receptor B/D (PPARB/D) in gastrointestinal tract function and disease (, Mus musculus,Rattus norvegicus,Homo sapiens)
• ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway (, NA)
• Cytoplasmic APC and the WNT signaling pathway (, NA)
• Some complement proteins can accelerate tumor growth (, NA)
• Diagrammatic representation of hormone therapy-induced changes in gene expression in the dorsal raphe block (, NA)
• Block diagram of JAK-STAT pathway (, NA)
• Histone Acetylation in Drug Addiction (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Porphyromonas gingivalis-Host Interactions: Open War or Intelligent Guerilla Tactics? (, NA)
• Identification of neuronal target genes for CCAAT/Enhancer Binding Proteins (, NA)
• Gene Expression, and Fatigue in Puerto Rican Men during Radiotherapy for Prostate Cancer: an exploratory study (, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Antiviral Immunity Directed by Small RNAs (, NA)
• Renaissance of complement therapeutics (, NA)
• Proposed signaling pathway of the extracellular nucleotide-induced phosphorylation of eNOS in EC (, NA)
• Cell biology of autophagy in metazoans: a developing story (, NA)
• Synthesis of modified mannosamines and sialic acids (, Homo sapiens)
• Personalized proteomics in proliferative vitreoretinopathy implicate hematopoietic cell recruitment and mTOR as a therapeutic target (, NA)
• FIBROTIC DISEASE AND THE TH1/TH2 PARADIGM (, NA)
• Ferritin functions as a proinflammatory cytokine via iron-independent PKC-ζ/NFKB-regulated signalling in rat hepatic stellate cells (, NA)
• Models to explain HDAC-mediated regulation of MHC gene expression during hypertrophy (, NA)
• Regulation of cell junction dynamics by cytokines in the testis – a molecular and biochemical perspective (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Load-driven signaling pathways predicted with ankle loading at 1 h after the last loading (, Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus,Diaporthe sclerotioides,Ovis aries)
• Heme-Oxygenase-1 Induced Protection Against Hypoxia/Reoxygenation is Dependent on Biliverdin Reductase and its Interaction with PI3K/Akt Pathway (, NA)
• Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression (, Homo sapiens,Mus musculus,Rattus norvegicus,Bos taurus,Escherichia coli,Oryctolagus cuniculus,Porphyromonas gingivalis,Papio hamadryas)
• Schematic showing inter-relationships of clustered genes associated with fatty acid, lipid and lipoprotein homeostasis based on differentially-expressed genes identified in lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice (, Homo sapiens,Mus musculus)
• Inter-relationships of genes associated with apoptosis differentially expressed in the lacrimal glands of C57BL/6.NOD-Aec1Aec2 mice (, Homo sapiens,Mus musculus)
• Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism (, Homo sapiens,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Callithrix jacchus)
• Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism (, Homo sapiens,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Callithrix jacchus)
• Aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism (, Homo sapiens,Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Callithrix jacchus)
• Schematic pathway of signaling in Plasmodium (, NA)
• Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease (, NA)
• Integrins in Lens Development and Disease (, NA)
• Primary targets of lithium in the cell are the glycogen synthase kinase 3/A (Gsk3/A) and inositol trisphosphate (InsP3) signalling pathways (, NA)
• Improving gemcitabine-mediated radiosensitization using molecularly targeted therapy: A review (, NA)
• Tumor Suppressor Candidate 2 (TUSC2; FUS-1) and Human Cancers (, Homo sapiens,Mus musculus)
• Proposed signaling pathways by which the Tec kinases regulate JNK activation, actin polymerization, and cytokine expression in LPS-stimulated neutrophils (, NA)
• Live Longer Sans the AT1A Receptor (, Homo sapiens,Mus musculus,Antarctothoa delta)
• Autophagy in the Pathogenesis of Disease (, NA)
• Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Synergistic combinations of signaling pathway inhibitors: Mechanisms for improved cancer therapy (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Store-operated Ca2+ entry in T cells (, NA)
• TNF-Induced MAP Kinase Activation Oscillates in Time (, Mus musculus,Homo sapiens)
• Raf>MEK>ERK and PI3K>Akt pathways on caspase 9 phosphorylation and the induction of drug resistance (, Mus musculus,Homo sapiens)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• ROLES OF THE RAF/MEK/ERK PATHWAY IN CELL GROWTH, MALIGNANT TRANSFORMATION AND DRUG RESISTANCE (, NA)
• Protein Acetylation Microarray Reveals NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster,Oryctolagus cuniculus,Trypanosoma brucei,Saccharomyces cerevisiae S288C,Homo sapiens,Escherichia coli)
• Resistance to echinocandin-class antifungal drugs (, Saccharomyces cerevisiae,Candida albicans,Homo sapiens)
• Comparison of VPC and HCG patterning networks in C (, Pristionchus pacificus,Homo sapiens)
• Bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease (, NA)
• Lipid rafts/caveolae as microdomains of calcium signaling (, NA)
• Different forms of regulation of ion channels relevant to Ca2+signaling (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Ciona intestinalis,Homo sapiens,Saccharomyces cerevisiae,Corynebacterium phage gamma,Mustela lutreola)
• Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity (, NA)
• COMMOM PATHWAYS FOR ACTIVATION OF PROINFLAMMATORY GENE EXPRESSION BY G PROTEIN-COUPLED RECEPTORS IN PRIMARY LUNG EPITHELIAL AND ENDOTHELIAL CELLS (, NA)
• Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)-retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line (, Homo sapiens)
• Biological actions of isoprenoids (, NA)
• BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway (, NA)
• Regulation of Vascular Permeability by Sphingosine 1-Phosphate (, Homo sapiens,Mus musculus,Canis lupus familiaris)
• The steroidogenic cascade involving the steroid hydroxylating cytochromes P450 (P450) that catalyze cleavage and/or hydroxylation of sequential substrates from cholesterol through pregnenolone, androstane and estrane (synthesis) (, Bos taurus,Canis lupus familiaris,Sus scrofa,Ovis aries,Equus caballus,Sus scrofa domesticus,Hippopotamus amphibius,Babyrousa babyrussa,Pecari tajacu,Tayassu pecari,Mus musculus,Rattus norvegicus,Danio rerio,Cavia porcellus,Cricetus cricetus,Oncorhynchus mykiss,teleost fish,Dipnomorpha,Homo sapiens,Saccharomyces cerevisiae,Branchiostoma lanceolatum)
• Proposed pathway for the interaction between ERA and growth factor (GF) signaling pathways and regulation by estradiol (E2) and progesterone (P4) (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Unifying model of TGFB signaling in breast epithelium (, NA)
• Relationships between metabolome, proteome, and genome in metabolic reprogramming of endothelial cells in PH (, NA)
• Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling (, NA)
• Hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Two B-hyperpaths computed in the full NCI-PID signaling pathway (, Homo sapiens,Lareunionomyces loeiensis)
• Small Wnt Pathway Solutions to nuclear Beta-catenin, denoted by a compartment marked ‘n’ for nucleus (, Homo sapiens,Lareunionomyces loeiensis)
• Large Wnt Pathway solutions (, Homo sapiens,Lareunionomyces loeiensis)
• NO–mediated endothelial paracrine signal (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of endothelial nitric oxide synthase (eNOS) by ROCKs (, Mus musculus,Homo sapiens)
• HuR and/or AUF1 differentially regulate mRNAs encoding cell cycle and Erk1/Erk2 Mapk signaling-related genes in MCT-1–transformed cells (, NA)
• BER subpathways for damaged bases and DNA strand breaks (, NA)
• PAF-induced enterocyte apoptosis and its inhibition by PUFA (, Rattus norvegicus,Homo sapiens)
• Ras signaling pathways (, Homo sapiens,Mus musculus,Mammuthus primigenius)
• Bile Acids in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bikinia letestui,Senna obtusifolia,Homo sapiens,NA)
• Biochemical, Cell Biological, Pathological, and Therapeutic Aspects of Krabbe Disease (, NA)
• Major mechanisms of therapeutic resistance to androgen axis-targeting therapies in prostate cancer (, NA)
• Gonadotropin regulation by pulsatile GnRH: signaling and gene expression (, NA)
• Gonadotropin regulation by pulsatile GnRH: signaling and gene expression (, NA)
• Recent mechanistic insights into the pathophysiology of antiphospholipid antibodies (aPL) and APS (, NA)
• Ezrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Canis lupus familiaris,vectors,Pleistophora sp. 1)
• VHL gene complex targets hypoxia-inducible factors (HIF) for ubiquitin-mediated degradation (, Homo sapiens)
• Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease (, NA)
• Two-signal model of T-cell activation (, Human gammaherpesvirus 4,Human immunodeficiency virus,Coxsackievirus A21,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• PD-1 and its downstream effect (, Human gammaherpesvirus 4,Human immunodeficiency virus,Coxsackievirus A21,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells (, NA)
• Combined Yeast-derived Beta-Glucan with Anti-tumor Monoclonal Antibody for Cancer Immunotherapy (, NA)
• Prospects for clinical cancer metabolomics using stable isotope tracers (, NA)
• An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (, NA)
• Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis (, NA)
• Induction of Distinct TLR2-Mediated Proinflammatory and Proadhesive Signaling Pathways in Response to Porphyromonas gingivalis Fimbriae (, NA)
• Complement in cancer: untangling an intricate relationship (, NA)
• Biologic actions of isoprenoids (, NA)
• VHL Loss of Function and Its Impact on Oncogenic Signaling Networks in Clear Cell Renal Cell Carcinoma (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Transcriptional regulation of human small nuclear RNA genes (, NA)
• Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Bos taurus)
• CD36: Implications in Cardiovascular Disease (, NA)
• Biochemical Signaling Pathways for Memory T cell Recall (, Homo sapiens,Mus musculus,Listeria monocytogenes)
• Induction of IFN-signaling pathways in HCV-infected uPA-SCID mice (A) and patients (B) (, Human immunodeficiency virus 1,Ebola virus,Non-A non-B hepatitis virus,Hepatitis C virus JFH-1,Homo sapiens,Pan troglodytes,Mus musculus,clinical samples,NA)
• Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Escherichia coli)
• Control of Cell Number in the Sexually Dimorphic Brain and Spinal Cord (, NA)
• Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites (, Schistosoma mansoni,Strongylocentrotus purpuratus,Nippostrongylus brasiliensis,Homo sapiens,Mus musculus)
• Apoptosis and Tumor Resistance Conferred by Par-4 (, NA)
• Cardioprotective Signaling to Mitochondria (, NA)
• Neuregulin 1 in neural development, synaptic plasticity and schizophrenia (, NA)
• ErbB proteins are type I transmembrane receptor tyrosine kinases (, NA)
• Sphingolipid metabolism in cancer signalling and therapy (, NA)
• SHP-2 IS A NOVEL TARGET OF ABL KINASES DURING CELL PROLIFERATION (, NA)
• NFKB activation in cancer (, NA)
• Regulation mechanisms for Itch-mediated Th2 differentiation.TCR triggering plus CD28-mediated costimulation results in the activation of MEKK1-JNK signaling pathway, which induces the serine/threonine phosphorylation of Itch (, NA)
• Unraveling the complexities of the interferon response during SARS-CoV infection (, Severe acute respiratory syndrome-related coronavirus,H5N1 subtype,Ebola virus,Murine hepatitis virus,SARS coronavirus NS-1,Homo sapiens,Mus musculus,Felis catus,Bacillus anthracis,NA,NA)
• Function of Nod-like Receptors in Microbial Recognition and Host Defense (, NA)
• Roles of TLR signaling in glial cells, endothelial cells, leukocytes and neuronal cells during the pathogenesis of ischemic stroke (, NA)
• TLR mediated signaling (, NA)
• Schematic model of insulin-stimulated glucose uptake in adipocytes (, Homo sapiens,Sus scrofa)
• Dual Role of Cyclin E in Cell Proliferation and Apotosis May Provide a Target for Cancer Therapy (, NA)
• OVARIAN CANCER (, NA)
• Involvement of p53 signaling after ROS generation (, NA)
• Crosstalk at the initial encounter: Interplay between host defense and ameba survival strategies (, Homo sapiens,Entamoeba histolytica)
• Integrin-RTK signaling (, NA)
• Combinatorial CRISPR-Cas9 metabolic screens reveal critical redox control points dependent on the KEAP1-NRF2 regulatory axis (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Genomic Landscape of Pheochromocytoma and Paraganglioma (, NA)
• Fanconi Anemia Signaling and Cancer (, NA)
• Hypothesis-Driven Medication Discovery for the Treatment of Psychostimulant Addiction (, Homo sapiens)
• Conversion of subendothelial macrophages into cholesterol-laden foam cells is believed to constitute the foundation of the atherosclerotic lesion (, NA)
• Abl Tyrosine Kinases in T-cell signaling (, NA)
• Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Brain arteriovenous malformation biology relevant to hemorrhage and implication for therapeutic development (, NA)
• Targeting the AMPK pathway for the treatment of Type 2 diabetes (, NA)
• Wnt/Beta-catenin signaling during early vertebrate neural development (, Gallus gallus,Danio rerio,Xenopus laevis,Xenopus tropicalis,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell (, NA)
• Apoptosis pathways (, Homo sapiens)
• Metabolism pathways (, Homo sapiens)
• Metabolism-mediated modification of pro-apoptotic proteins (, Homo sapiens)
• ESSENTIAL ROLE OF ERK IN 4-OXO-2-NONENAL MEDIATED CYTOTOXICITY IN SH-SY5Y HUMAN NEUROBLASTOMA CELLS (, NA)
• mTORC1 activation by nutrients and growth factors (, Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Signaling via the TgfB type I receptor Alk5 in heart development (, NA)
• A novel pathway for heme oxygenase/carbon monoxide-dependent cyclic GMP signaling based on the newly described sGC/cyclic GMP-modulating agents YC-1 and BAY 41-2272 as shown (, Homo sapiens)
• Postnatal Roles of GDNF Family Members in Nociceptors Plasticity (, Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens)
• Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Sequoia sempervirens,Raphanus sativus,Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Pathways analysis on the set of genes contained in the SNP component (, Homo sapiens,Sequoia sempervirens)
• Oncogenic Gene Fusions in Epithelial Carcinomas (, Homo sapiens,Mus musculus)
• Regulation of p53 and MDM2 and the outcomes of p53 activation (, NA)
• INHIBITOR OF APOPTOSIS (IAP) PROTEINS IN EUKARYOTIC EVOLUTION AND DEVELOPMENT: A MODEL OF THEMATIC CONSERVATION (, NA)
• Mechanism of action of toll-like receptors (TLRs) (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• Crosstalk via the NFKB Signaling System (, Mus musculus,Homo sapiens)
• Regulation of Signal Transduction by DJ-1 (, NA)
• Regulation of Signal Transduction by DJ-1 (, NA)
• Regulation of Signal Transduction by DJ-1 (, NA)
• Severe congenital neutropenias (, NA)
• Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy (, NA)
• GST-MDA-7 causes PERK-dependent vacuolization and JNK pathway activation in transformed cells that leads to cell death (, Homo sapiens)
• Signaling cascade of PI3K/AKT pathway (, NA)
• Toll-like Receptors: Novel Pharmacological Targets for the Treatment of Neurological Diseases (, NA)
• Role of Adenomatous Polyposis Coli (APC) and Microtubules in Directional Cell Migration and Neuronal Polarization (, NA)
• Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation (, Mus musculus,Homo sapiens)
• Activin Modulates the Transcriptional Response of LBT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation (, Mus musculus,Homo sapiens)
• Unifying model of Wnt signaling with regard to cardiomyogenesis (, NA)
• Oncogenic Function of ATDC in Pancreatic Cancer Through Wnt Pathway Activation and Beta-catenin Stabilization (, Homo sapiens,Mus musculus)
• Thyroid Carcinoma: Molecular Pathways and Therapeutic Targets (, NA)
• Prodeath or Prosurvival: Two Facets of Hypoxia Inducible Factor-1 in Perinatal Brain Injury (, NA)
• ALPS and CEDS illustrate signaling pathways for lymphocyte apoptosis and activation (, Homo sapiens)
• Lessons from characterization and treatment of the inflammatory syndromes (, NA)
• MTOR signaling pathway and the cell cycle pathway associated with lung adenocarcinoma as reported in (, Homo sapiens,Bacillus phage Gamma,Euscorpius gamma)
• PLA2 and PI3K/PTEN regulate chemotaxis in Dictyostelium (, Homo sapiens)
• PBT-1 induced genes in different pathways according to the KEGG and BIOCARTA pathway databases (, Armoracia rusticana,Vincetoxicum indicum,Vincetoxicum hirundinaria,Vincetoxicum tanakae,Homo sapiens,Mus musculus,Bos taurus,Ideopsis similis)
• Tumor resistance to EGFR-targeted therapies (, NA)
• Growth factor interaction with growth factor receptors on the cell surface to initiate PI3K/Akt pathway responsible for cell cycle progression, survival, and proliferation (, NA)
• Mitochondrial Nuclear Receptors and Transcription Factors: Who’s Minding the Cell? (, NA)
• Simplified model for the involvement of cell cycle proteins in the regulation of survival and differentiation by neuronal chemokine receptors: SDF-1A may affect expression of survival genes by regulating Rb and E2F-1 function (, Human immunodeficiency virus 1,Human immunodeficiency virus,Rattus norvegicus,Homo sapiens)
• Generalized schematic presentation of signaling pathways targeted by molecular therapies in malignant glioma (, NA)
• Tyrosine kinase network regulating mast cell activation (, Mus musculus,Rattus norvegicus,Homo sapiens,Antarctothoa delta,NA)
• CCN1 signaling and crosstalk with TNFA (, Gallus gallus,Danio rerio,Xenopus laevis,Mus musculus,Rattus norvegicus,Coxsackievirus B3,Avian myeloblastosis-associated virus type 1,Homo sapiens)
• Mechanotransduction gone awry (, NA)
• UPS presynaptic pathways (, NA)
• Pericyte: Cellular regulator of microvascular blood flow (, NA)
• Krüppel-like factor 5 mediates the transforming activity of oncogenic H-Ras (, NA)
• Novel NFKB-inducing Kinase-MAPK Signaling Pathway Up-regulates NFKB Activity in Melanoma Cells (, Homo sapiens)
• Tumorigenesis in the adrenal cortex (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Notolabrus celidotus,Euphydryas colon,NA)
• Protein Scaffolds in MAP Kinase Signalling (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio)
• Angiotensin converting enzyme 2 in the brain (, NA)
• Model for GalR1 neuroplasticity within the LC (, NA)
• TGFB superfamily signaling: notes from the desert (, NA)
• Paracrine mechanisms in adult stem cell signaling and therapy (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Genome Wide Analysis Reveals Inositol, not Choline, as the Major Effector of Ino2p-Ino4p and Unfolded Protein Response Target Gene Expression in Yeast (, NA)
• Toll-Like Receptors and Corneal Innate Immunity (, NA)
• Proposed Src involvement in HCEC wound healing (, Homo sapiens)
• TLR signaling and the role of epithelium in corneal innate defense (, NA)
• Interactions between injury and endogenous repair processes (, NA)
• Differential Requirement for MEK/ERK and SMAD Signaling in PAI-1 and CTGF Expression in Response to Microtubule Disruption (, NA)
• Proposed pathways influencing adiposity in C (, NA)
• Myeloid Notch1 Deficiency Activates RhoA/ROCK Pathway And Aggravates Hepatocellular Damage In Mouse Ischemic Livers (, NA)
• Ty retrotransposition cycle (, Homo sapiens,Saccharomyces cerevisiae)
• Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin-Dependent N-End Rule Pathway (, NA)
• Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells (, Homo sapiens)
• Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth FactorB1 in Mesenchymal Cells Is Mediated by p38 MAPK-dependent Induction of an Autocrine Growth Factor (, Homo sapiens)
• Molecular and cellular biology of enhanced cognition (, NA)
• Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity (, NA)
• Working model for the effects of 15d-PGJ2 and thiazolidinediones on TNF-stimulated NFKB activation and COX2 expression (, Homo sapiens)
• Role of Ang II signaling in adverse myocardial remodeling (, NA)
• DNA Damage Tolerance: When It’s OK to Make Mistakes (, NA)
• Toll-like receptor signaling pathways in the prefrontal cortex (, NA)
• Targeting Bromodomain and Extraterminal Proteins in Breast Cancer (, NA)
• Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88 Dependent and Independent Signaling and is Reciprocally Modulated by LXR Activation (, NA)
• T cell differentiation proceeds along distinct pathways following antigen presentation by DCs (, Lareunionomyces loeiensis,Malus domestica,Allium cepa,Trifolium pratense,Mus musculus,Rattus norvegicus,Salmonella enterica subsp. enterica serovar Typhimurium,Influenza A virus,Listeria monocytogenes,unidentified influenza virus,Homo sapiens,Gallus gallus,Ovis aries)
• Current evidence on statin use and prostate cancer prevention: are we there yet? (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Signaling via RAGE (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Human gammaherpesvirus 4,Plantago princeps)
• Dual-targeting Wnt and uPA Receptors Using Peptide Conjugated Ultra-small Nanoparticle Drug Carriers Inhibited Cancer Stem-Cell Phenotype in Chemo-Resistant Breast Cancer (, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis)
• Mode of BMP signaling determines Smad dependent and independent pathways (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Mus musculus,Rattus norvegicus,Mandrillus leucophaeus)
• Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death (, NA)
• Cascade of events that follows a hypoxic-ischemic insult and over-stimulation of glutamate receptors in the brain (, Homo sapiens)
• Brain-immune interactions in perinatal hypoxic-ischemic brain injury (, NA)
• Lysophosphatidic Acid Signaling in Airway Epithelium: Role in Airway Inflammation and Remodeling (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Schistosoma mansoni)
• Inhibition of Butyrylcholinesterase with Fluorobenzylcymserine, An Experimental Alzheimer’s Drug Candidate: Validation of Enzoinformatics Results by Classical and Innovative Enzyme Kinetic Analyses (, NA)
• Lysophosphatidic Acid Induces Interleukin-13 (IL-13) Receptor A2 Expression and Inhibits IL-13 Signaling in Primary Human Bronchial Epithelial Cells (, Homo sapiens)
• Interleukin-31 acts through three signaling pathways: Jak/STAT pathway, PI3K/AKT pathway and MAPK pathway (, NA)
• MET as a target for treatment of chest tumours (, NA)
• ANASTELLIN, THE ANGIOSTATIC FIBRONECTIN PEPTIDE, IS A SELECTIVE INHIBITOR OF LYSOPHOSPHOLIPID SIGNALING (, NA)
• AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration (, NA)
• Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism (, NA)
• Proposed mechanism by which PKCA regulates Ca2+ sparklet activity in arterial myocytes (, NA)
• ErbB Receptors in the Biology and Pathology of the Aerodigestive Tract (, Homo sapiens,Mus musculus,Nicotiana tabacum,Helicobacter pylori,Human papillomavirus)
• Calcium store-mediated signaling in sustentacular cells of the mouse olfactory epithelium (, NA)
• Pathway maps generated using GenMapp depicting increased glycolytic protein expression in differentiated intestinal epithelial cells relative to crypt cells (, NA)
• Crosstalk between the Androgen Receptor and Beta-Catenin in Castrate Resistant Prostate Cancer (, NA)
• Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Mouse Liver (, Saccharomyces cerevisiae,Olea europaea,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio)
• Time-course Comparison of Xenobiotic Activators of CAR and PPARA in Liver (, Saccharomyces cerevisiae,Olea europaea,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio)
• Cellular retinoid metabolism (, NA)
• THE PRIMARY CILIUM: AT THE CROSSROADS OF MAMMALIAN HEDGEHOG SIGNALING (, Homo sapiens)
• PRIMARY CILIUM: AT THE CROSSROADS OF MAMMALIAN HEDGEHOG SIGNALING (, Homo sapiens)
• Basic Helix-Loop-Helix Factor Hand2 Regulates Autonomic Nervous System Development (, NA)
• PML regulon model is used to explain the effects of the PML protein and PML nuclear bodies on survival signaling as described in the text (, NA)
• Detailed qualitative dynamic knowledge representation using a BioNetGen model of TLR-4 signaling and preconditioning (, NA)
• Dual Roles of Nrf2 in Cancer (, Armoracia rusticana,Solanum lycopersicum,Allium sativum,Zingiber officinale,Cinnamomum verum,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• TLRs/NODs and key intracellular signaling cascades (, NA)
• Tumor Necrosis Factor-like Weak Inducer of Apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta activated kinase 1 (, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• INNATE IMMUNE CONTROL OF ALPHAVIRUS INFECTION (, NA)
• Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network (, NA)
• The Importance of NAD in Multiple Sclerosis (, NA)
• Emerging Role of Adipose Tissue Hypoxia in Obesity and Insulin Resistance (, NA)
• Akt-dependent and independent mechanisms of mTOR regulation in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Akt-dependent and independent mechanisms of mTOR regulation in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Akt-dependent and independent mechanisms of mTOR regulation in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Model showing the activation of the JNK pathway upon challenge by UVB (, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Armoracia rusticana,vectors,Dipturus trachyderma)
• Mechanisms underlying the neuroprotective effects of calorie restriction (, NA)
• CK1 in Developmental signaling: Hedgehog and Wnt (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Eucalyptus intertexta,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• Estradiol action on hypothalamic cells (, NA)
• Specific desensitization of GCB by S1P (, NA)
• Proposed signaling pathway underlying PMA-induced activation of the Tspo promoter (, NA)
• IGF-1 signaling mediated cell-specific skeletal mechano-transduction (, NA)
• Cell-specific requirements for STAT proteins and type I IFN receptor signaling discretely regulate IL-24 and IL-10 expression in NK cells and macrophages (, Escherichia coli,Listeria monocytogenes,Yersinia pestis,Yersinia pestis 24H,Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Murid betaherpesvirus 1)
• Interleukin (IL)-6-signaling pathways with potential drug targets (, NA)
• Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy (, NA)
• Lipids involved in TGN trafficking (, Homo sapiens,Saccharomyces cerevisiae)
• Working model of the signaling pathway components that are differentially regulated in C57BL/6 and CD-1 pup brain tissues and cultured NPCs under normoxic and hypoxic conditions (, NA)
• METABOLIC SWITCHING AND CELL FATE DECISIONS: IMPLICATIONS FOR PLURIPOTENCY, REPROGRAMMING AND DEVELOPMENT (, NA)
• NAD+ intermediates: The biology and therapeutic potential of NMN and NR (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Bos taurus,Canis lupus familiaris,Ipomoea batatas,Homo sapiens,unidentified,Paracentrotus lividus)
• From the diet to the nucleus: Vitamin A and TGFB join efforts at the mucosal interface of the intestine (, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatovirus A)
• Herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by NGF deprivation through inhibition of caspase-3 activation and XIAP upregulation (, Rattus norvegicus,Human alphaherpesvirus 2,Chlorocebus aethiops,Homo sapiens)
• De novo purine biosynthesis pathway (, NA)
• Posttranscriptional regulation of gene networks by GREs (, NA)
• Retinoic acid dependent regulation of immune responses by dendritic cells and macrophages (, NA)
• Role for PPAR signaling in alternative (M2) macrophage activation (, NA)
• Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes (, NA)
• Insulin and amino acid signaling pathway leading to the stimulation of translation initiation (, NA)
• Regulation of Neural Progenitor Cell Development in the Nervous System (, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Gallus gallus,Xenopus laevis,Macaca mulatta,Mustela putorius furo,Drosophila melanogaster)
• Smad3 in TGFB–mediated proapoptotic transcriptional responses (, Homo sapiens,Mus musculus)
• Smad3 in TGFB–induced antiproliferative transcriptional responses (, Homo sapiens,Mus musculus)
• Sites of action for reactive oxygen species in the regulation of the insulin signaling pathway (, NA)
• Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity (, NA)
• Transcriptomes in Healthy and Diseased Gingival Tissues (, Homo sapiens,Rattus norvegicus,Nicotiana tabacum,Helicobacter pylori)
• TGFB/SMAD signaling pathway (, Homo sapiens,Rattus norvegicus)
• New central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9 (, NA)
• Role of IRS-1 in insulin and IGF-1 signaling (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Betapolyomavirus macacae,Panthera pardus)
• Activation of Nrf2-mediated ARE pathway by phytochemicals (, Homo sapiens)
• Core signaling pathway downstream from V2R occupation in IMCD (, Rattus norvegicus,Homo sapiens)
• Kinetic Scheme for the 5-HT1AR and 5-HT2AR mediated MAP kinase activation pathway (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Xenopus laevis)
• Neurotrophic Factors and Structural Plasticity in Addiction (, NA)
• PI3K/Akt non-Smad pathway (, NA)
• Small GTPase non-Smad pathway (, NA)
• JNK/p38 non-Smad pathway (, NA)
• Erk non-Smad pathway (, NA)
• CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC PROTEASE (, Homo sapiens,Mus musculus)
• CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC PROTEASE (, Homo sapiens,Mus musculus)
• 13C metabolic flux analysis of E (, NA)
• Myeloid diversion pathways for advanced pro-T cells by re-introduction of C/EBPA or PU.1 (, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Stepwise respecification of ETP and DN2 cells by GATA-3 overexpression (, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Leptin Neuroprotection in the Central Nervous System: Mechanisms and Therapeutic Potentials (, NA)
• Pediatric Pharmacogenomics: A systematic assessment of ontogeny and genetic variation to guide the design of statin studies in children (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Mechanism of PD-1 and PDL-1 pathway in tumor environment and the complex crosstalk between cancer, tumor, T-cell, APC and macrophage and tumor stroma (, NA)
• Regulation of canonical and noncanonical pathways of NFKB activation by cylindromatosis (CYLD) (, NA)
• Complement System and Preeclampsia (, NA)
• INTEGRATING RADIOTHERAPY WITH EGFR ANTAGONISTS AND OTHER MOLECULAR THERAPEUTICS FOR THE TREATMENT OF HEAD AND NECK CANCER (, NA)
• GenMapp pathway showing the impact of 1 week of STZ-DM on transcription in pathways related to cytokines and the inflammatory response (, NA)
• Putative model illustrating the interplay between RANK/NFKB-dependent and Hdac3-dependent control of mTEC development (, NA)
• MiR-103/107 and PANKs may constitute coordinated transcription units with synergistic cellular effects concerning cellular acetyl-CoA levels and other metabolic pathway elements (, NA)
• Toll-like receptors in skin (, NA)
• Cellular pathways targeted by drugs which induce apoptosis in HTLV-1-infected cells (, NA)
• Transcriptomic data shows immunometabolic effects of vitamin D (, Homo sapiens,Mycobacterium tuberculosis)
• Transcriptomic data shows immunometabolic effects of vitamin D (, Homo sapiens,Mycobacterium tuberculosis)
• Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls (, NA)
• UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes (, NA)
• Compatible solute biosynthesis (, NA)
• Molecular Regulation of Follicle-Stimulating Hormone Synthesis, Secretion and Action (, NA)
• Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells (, NA)
• Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin (, NA)
• The Wnt Signaling Pathway in Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Non-Canonical Wnt-signaling: Non-canonical Wnt/PCP (planar cell polarity) pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Wnt Signaling Pathway in Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Canis lupus,Mus musculus,Rattus norvegicus,Heterocephalus glaber,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Matthiola incana)
• Death receptor-mediated apoptosis signaling (, Homo sapiens,Mus musculus)
• Tumor necrosis factor and cancer, buddies or foes? (, NA)
• Ca2+/calmodulin (CaM)-dependent kinase (CaMK) and Ca2+/CaM-dependent phosphatase pathways (, NA)
• Semaphorins and their receptors in lung cancer (, NA)
• DAF-2 Insulin-like Signaling Pathway Independently Regulates Aging and Immunity (, Homo sapiens,Caenorhabditis elegans)
• FoxO proteins employ multiple signal transduction pathways that affect cell proliferation, survival and immune system function (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Danio rerio,Xenopus laevis,Homo sapiens,Human gammaherpesvirus 8,Vasconcellea candicans,Sulfolobus turreted icosahedral virus 1)
• Renin cells in homeostasis, regeneration and immune defence mechanisms (, NA)
• Regulation of G1/S transition by growth factor (insulin and IGF-I) signaling in Beta-cells (, Mus musculus,Rattus norvegicus,Meriones unguiculatus,Homo sapiens)
• Regulation of ROS-mediated activation of the p38 MAPK stress response signaling pathway (, Mus musculus,Homo sapiens)
• Regulation pathways of Arc transcription in BDNF- and Ca2+-mediated signaling (, NA)
• Cell specific APC protective signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed potential therapeutic targets in Erythroleukemia (, Spleen focus-forming virus,Friend murine leukemia virus,Friend spleen focus-forming virus,Homo sapiens,Mus musculus,clinical samples)
• Proposed pathway (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Capra hircus,Lactobacillus sp.,Escherichia coli O127B8,Homo sapiens)
• Wnt/Beta-catenin signaling pathway in leukemia (, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Role of the ATM-p53 pathway in IR-induced apoptosis of developing CNS (, NA)
• Alternative splicing in the NFKB signaling pathway (, NA)
• Schematic of the predicted signalling pathways for HagB-induced MMP production in dendritic cells (, NA)
• How radiation impacts tumor and immune cells to modulate the immunological response (, NA)
• Multifaceted Fanconi Anemia Signaling (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Rotavirus infection (, NA)
• Does Inhibition of Glycogen Synthase Kinase Protect in Mice? (, NA)
• Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus (, Influenza A virus,unidentified influenza virus,Orthomyxoviridae,Homo sapiens,Mus musculus)
• Luteolin, a flavonoid with potentials for cancer prevention and therapy (, Malus domestica,Fragaria x ananassa,Allium cepa,Daucus carota,Punica granatum,Capsicum annuum,Petroselinum crispum,Apium graveolens Dulce Group,Taraxacum officinale,Perilla frutescens,Melissa officinalis,Rubus occidentalis,Zostera marina,Vitex trifolia,Mus musculus,Rattus norvegicus,Homo sapiens,Opsanus beta,Leishmania donovani)
• IL-6 signalling pathways (, Homo sapiens)
• Targeting the IL-6/JAK/STAT3 signalling axis in cancer (, Homo sapiens)
• Regulation of IGF-I Function by Proinflammatory Cytokines: At the Interface of Immunology and Endocrinology (, Homo sapiens,Mus musculus)
• PCPH/ENTPD5 expression confers to prostate cancer cells resistance against cisplatin-induced apoptosis through PKCAlpha-mediated Bcl-2 stabilization (, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Antarctothoa delta)
• Tibolone Rapidly Attenuates the GABAB Response in Hypothalamic Neurones (, NA)
• Canonical and noncanonical NFKB signaling pathways (, Homo sapiens,Mus musculus,Human adenovirus 5,Beta vulgaris subsp. maritima)
• Antitumor activity and resistance of the inhibitor PX-866 (, NA)
• Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways (, NA)
• A theoretical pancreatic endocrine tumor cell, smooth muscle cell (pericyte) or endothelial cell demonstrating the sites and mechanism of action of novel agents for the management of metastatic PETs (, NA)
• Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells (, NA)
• Human binge alcohol intake inhibits TLR4-MyD88 and TLR4-TRIF responses but not TLR3-TRIF pathway: HspA1A and PP1 play selective regulatory roles (, unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Escherichia coli,NA)
• Pathways involved in folate-dependent methionine transmethylation and transsulfuration (, NA)
• Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence (, NA)
• Chronic colon colitis model (, NA)
• Comparing and Contrasting the Roles of AMPK and SIRT1 in Metabolic Tissues (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, Metabolic and Disease Implications (, NA)
• Working model of the Smac-mimetic IAP-inhibitors in radiosensitization (, NA)
• Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration (, NA)
• AR signaling and therapeutic interventions in TNBC (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Estradiol and the Control of Feeding Behavior (, NA)
• Ageing, oxidative stress and cancer: paradigms in parallax (, NA)
• JAK/STAT signaling pathway (, NA)
• Hh-Gli pathway and the Gli code in tissue patterning and stem-cell lineages (, NA)
• Membrane-initiated Estrogen Signaling in Hypothalamic Neurons (, NA)
• Membrane Recruitment as a Cancer Mechanism: A Case Study of Akt PH Domain (, NA)
• Apoptosis and Autophagy: regulatory connections between two supposedly different processes (, NA)
• Apoptosis and Autophagy: regulatory connections between two supposedly different processes (, NA)
• Phosphatidylcholine (PC) metabolism and Alzheimer’s disease (AD) (, NA)
• Role of Programmed Cell Death in the Immunopathogenesis of Sepsis (, NA)
• MTOR signaling pathway with potential contributions from GABA and Glu receptors (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Saccharomyces cerevisiae SK1,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Wnt/Beta-catenin signaling pathway (, NA)
• Molecular Genetics of Colorectal Cancer: An Overview (, NA)
• Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension (, NA)
• Retrosynthetic analysis for lipid II (, NA)
• Dopamine Transporter Constitutively Internalizes and Recycles in a Protein Kinase C-regulated Manner in Stably Transfected PC12 Cell Lines (, NA)
• Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension (, NA)
• SOCS Regulation of the JAK/STAT Signalling Pathway (, NA)
• TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway (, NA)
• TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway (, NA)
• The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway (, NA)
• Possible scheme for ES cell differentiation and the role of specific factors in the formation of primitive ectoderm and primary germ layers (, NA)
• Pathways of apoptosis (, Homo sapiens)
• Nuclear Factor-kappa B Signaling in Skeletal Muscle Atrophy (, NA)
• Obesity and Free Fatty Acids (FFA) (, Mus musculus,Rattus norvegicus,Homo sapiens)
• TNFR1 and LTBR ligation-induced signaling in vascular EC (, Homo sapiens)
• Schematic diagram illustrating two opposing signaling pathways activated by DFMO-mediated polyamine depletion in NB cells (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Regulation of metastasis in colorectal adenocarcinoma: A collision between development and tumor biology (, NA)
• Raf/MEK/ERK Pathway (, NA)
• PI3K/PTEN/Akt/mTOR Pathway (, NA)
• Free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines (, NA)
• Free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines (, NA)
• Hepatitis C and Innate Immunity – Recent Advances (, NA)
• Model based on studies of the activation of JNK pathway upon generation of H2O2 in rat alveolar macrophages () and in human bronchial epithelial cells (HBE1) exposed to HNE () (, NA)
• Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock (, NA)
• Possible cellular mechanisms involved in calycopterin-induced apoptosis in HepG2 cells (, Saccharomyces cerevisiae,Morus alba,Dracocephalum kotschyi,Homo sapiens,Mus musculus,Bos taurus)
• mTOR inhibition as a Therapeutic Strategy in the Management of Urologic Malignancies (, NA)
• Sulfur switches can exist as "Redox Sensors" and as "Redox Rheostats" in generic redox circuitry models (, NA)
• Targeting EGFR and Src Pathways in Head and Neck Cancer (, Homo sapiens)
• PI3K pathway as affected by IGF2 administration based on Pathway-Express (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,Labeo bata)
• TGFB pathway as affected by IGF2 administration based on Pathway-Express (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana,Labeo bata)
• The involvement of TNFAlpha-mediated signaling pathways in insulin resistance (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Respective balance between Gi- and Gs-dependent signalling pathways and their roles in the modification of FcARI-mediated mast cell degranulation (, NA)
• Protein kinase C isozymes as therapeutic targets for treatment of human cancers (, Mus musculus,Rattus norvegicus,Homo sapiens,Lambdavirus lambda)
• Plasticity within striatal direct pathway neurons following neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 Map Kinase pathway (, Rattus norvegicus,Homo sapiens)
• Plasticity within striatal direct pathway neurons following neonatal dopamine depletion is mediated through a novel functional coupling of serotonin 5-HT2 receptors to the ERK 1/2 Map Kinase pathway (, Rattus norvegicus,Homo sapiens)
• Possible scenarios for coupling between Stim1 and Orai1 in SOC activation (, NA)
• Cross-talk between protein synthesis, energy metabolism and autophagy in cancer (, NA)
• Highly simplified diagram of signaling pathways involving Beta-catenin that may be relevant for RPE cell morphogenesis and susceptibility to age-related oxidative stress (, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Gallus gallus,Human betaherpesvirus 5)
• Migrating D-loop model of recombination (, NA)
• ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY (, NA)
• ALTERATION OF AKT ACTIVITY INCREASES CHEMOTHERAPEUTIC DRUG AND HORMONAL RESISTANCE IN BREAST CANCER YET CONFERS AN ACHILLES HEEL BY SENSITIZATION TO TARGETED THERAPY (, NA)
• Transcriptional and Translational Regulation of Transforming Growth FactorB Production in Response to Apoptotic Cells (, Mus musculus,Rattus norvegicus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Homo sapiens,Bos taurus,Escherichia coli,Armoracia rusticana)
• Eicosanoid Lipid Mediators in Fibrotic Lung Diseases: Ready for Prime Time? (, Homo sapiens)
• Information flow through the JNK network (, Drosophila melanogaster,Homo sapiens)
• Activation of the mammalian target of rapamycin (mTOR) pathway can result from numerous glioma-associated genetic changes (, Homo sapiens,Mus musculus)
• Hypothetical model for AVP concentration-dependent transitions between Ca2+ entry and Ca2+ release (, Rattus norvegicus,Homo sapiens)
• Bile acid and cytokine inhibition of CYP7A1 gene transcription (, Homo sapiens)
• HIV-1 infected astrocytes and the microglial proteome (, Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Mus musculus)
• Metabolism of sulforaphane involving (A) hydrolysis of glucosinolate to its isothiocyanate via myrosinase enzyme activity and (B) metabolism of SFN via the mercapturic acid pathway (, NA)
• Proposed signaling pathway (, Mus musculus,Homo sapiens)
• Classification and regression tree analysis of genetic polymorphisms in cell cycle pathways and smoking status with OPL risk (, Homo sapiens,Nicotiana tabacum)
• Injury and Nucleotides Induce Phosphorylation of Epidermal Growth Factor Receptor: MMP and HB-EGF Dependent Pathway (, NA)
• Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-ALL (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: a one-carbon metabolism candidate gene study (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Amphilophus globosus)
• RLR signaling pathway and its negative regulatory molecules (, NA)
• Most prominently involved biological pathways in OSCC (, Homo sapiens,Mus musculus,Nicotiana tabacum,Human papillomavirus,Pieris rapae)
• Therapeutic targets of the AR pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries,Streptomyces hygroscopicus)
• Oxysterol-Induced Osteogenic Differentiation of Marrow Stromal Cells is Regulated by Dkk-1 Inhibitable and PI3-Kinase Mediated Signaling (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Armoracia rusticana)
• Two pathways via which binding of cardiotonic steroids to the Na+/K+-ATPase exerts genomic and non-genomic effects (, Homo sapiens)
• Iron–sulfur (Fe-S) cluster biogenesis in eukaryotes (, Saccharomyces cerevisiae,Arabidopsis thaliana,Trachipleistophora hominis,Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Synechococcus elongatus PCC 6301,Homo sapiens,Mus musculus,Danio rerio)
• Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer’s Disease (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Activation of microglia with zymosan promotes excitatory amino acid release via volume-regulated anion channels: the role of NADPH oxidases (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Saccharomyces cerevisiae)
• Store-operated Ca2+ entry in T cells (, Mus musculus,Homo sapiens)
• Inhibition of the BRCA1 DNA damage response pathway indicated by a down modulation (green; up-modulation is indicated in red) of atm, brip1, cdkn1a, e2f3, fancd2, fancl, mdc1, rad51, and rpa1 in male X (, Xiphophorus maculatus,Homo sapiens)
• Simplified repression model of angptl3 promoter activity by PPARB (, Homo sapiens,Mus musculus)
• Hematopoietic niche and bone meet (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and Forkhead signaling? (, NA)
• Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and Forkhead signaling? (, NA)
• MOLECULAR TARGETED THERAPIES FOR PANCREATIC CANCER (, Homo sapiens,Mus musculus,Nicotiana tabacum)
• MOLECULAR TARGETED THERAPIES FOR PANCREATIC CANCER (, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Ubiquitin Signaling in the NFKB Pathway (, NA)
• Ubiquitin Signaling in the NFKB Pathway (, NA)
• Ubiquitin Signaling in the NFKB Pathway (, NA)
• Oncogenic signaling networks by Kaposi’s sarcoma-associated herpesvirus (, NA)
• These data suggest that arsenicals activate MAPK signaling both through ROS, as well as by direct association () (, Homo sapiens)
• Diagramatics representation of the estrogen signal transduction pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of the cytoskeleton in flow (shear stress)-induced dilation and remodeling in resistance arteries (, NA)
• Mechanisms that may result in perturbed neuronal Ca2+ homeostasis in Alzheimer’s disease (, NA)
• Physiology and role of irisin in glucose homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Physiology and role of irisin in glucose homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Physiology and role of irisin in glucose homeostasis (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio)
• Extranuclear Signaling by Sex Steroid Receptors and Clinical Implications in Breast Cancer (, NA)
• Phospholipase A2 (PLA2) catalyzes phosphatidylcholine into AA in response to agonist stimulation of a G-protein–coupled cell surface receptor (, NA)
• Molecular pathway triggered by RARB2 for the suppression of human carcinogenesis (, NA)
• Notch signaling pathway (, NA)
• Ischemia induces cell death by several distinct pathways, and Hsp70 reduces all of these (, NA)
• PGE2 formation and its signal transduction pathways (, NA)
• Canonical Wnt signaling pathway (, NA)
• Gut microbiota and IBD: causation or correlation? (, NA)
• Display of differentially expressed genes in the uterine cervix after term spontaneous labor mapped on the PLAU signaling pathway (, Homo sapiens)
• Insulin receptor signaling (, Homo sapiens,Escherichia phage T7)
• MSn fragmentation scheme defining the major fragmentation Pathways I and II, of Francisella lipid A species and isobaric lipid A species featuring heterogeneous acyl chain distribution (, Francisella tularensis)
• AMPK: an energy-sensing pathway with multiple inputs and outputs (, NA)
• Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP (, NA)
• The central role of hepatocyte apoptosis in liver injury (, NA)
• ER stress pathway (, NA)
• Extrinsic and intrinsic pathways of hepatocyte apoptosis (, NA)
• Foxo3 regulation by PI3K-Akt signaling pathway within oocytes in the control of primordial follicle activation (, Mus musculus,Homo sapiens)
• IL-6 signaling and therapeutic targets in CCA (, NA)
• Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits GA13/RhoA-mediated Migration (, NA)
• Optogenetically controlled protein kinases for regulation of cellular signaling (, NA)
• During cellular oxidative stress, especially vascular oxidative stress, a host of cellular pathways are activated that directly result in the enzymatic formation of ROS and reactive nitrogen species (RNS), () (, NA)
• PPARG in Type 1/Type 2 T (NK) cell differentiation (, Homo sapiens)
• 15d-PGJ2 actions (, Homo sapiens)
• Synthesis of 15d-PGJ2 (, Homo sapiens)
• Proposed EphB2 signaling network (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cartoon schematic showing the mTOR signaling pathway in cells (, Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• Wnt, Activin, and BMP Signaling Regulate Distinct Stages in the Developmental Pathway from Embryonic Stem Cells to Blood (, Mus musculus,Homo sapiens)
• Wnt signaling: the good and the bad (, Gallus gallus,Danio rerio,Xenopus laevis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Developmental signaling pathways (, NA)
• Graphic illustrating the roles of 8 genes implicated in the present study in lithium-sensitive signaling pathways (, NA)
• Microbiome series (, NA)
• Interferon-inducible antiviral effectors (, NA)
• Directional Sensing During Chemotaxis (, Homo sapiens,Mus musculus)
• Intrinsic apoptotic signaling pathway (, NA)
• Extrinsic apoptotic signaling pathway (, NA)
• HIV-1 Eradication: Early Trials (and Tribulations) (, Homo sapiens,Macaca mulatta,Mus musculus,Human immunodeficiency virus 1,Diaporthe sclerotioides,Petrocephalus catostoma)
• Role of mTOR in anticancer drug resistance (, NA)
• The Transcriptional Response of Skin to Fluorescent Light Exposure in Viviparous (Xiphophorus) and Oviparous (Danio, Oryzias) Fishes (, NA)
• Platyfish significantly down modulate the IGF signaling pathway leading to a suppression of cell proliferation, cell growth and cell survival in skin following FL exposure (, NA)
• In zebrafish following FL exposure, the most significantly modulated pathway in skin is the oncostatin M pathway (, NA)
• Platyfish skin (A) significantly down modulates the PPARA/RXRA signaling pathway in response to FL; however, both medaka (B) and zebrafish (C) significantly up-modulate the PPARA/RXRA pathway in skin following FL exposure (, NA)
• NOVEL VIP SIGNALING PATHWAY IN T CELLS cAMP→ Protein Tyrosine Phosphatase (SHP-2?)→JAK2/STAT4→Th1 differentiation (, NA)
• Alterations in glucose and glutamine metabolism contribute to tumor growth and proliferation (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus)
• PI-3kinase pathway in hematopoietic stem cells and leukemia-initiating cells: a mechanistic difference between normal and cancer stem cells (, NA)
• Regulation of ER-stress by p38 and tumor dormancy (, NA)
• Sepsis and insights from clinical trials (, Homo sapiens)
• Canonical PI3K/AKT/mTOR signaling pathway (, NA)
• Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective (, NA)
• Epidermal Growth Factor Receptor Signaling to the MAPK Pathway Bypasses RAS in Pancreatic Cancer Cells (, Bos taurus,Equus caballus,Homo sapiens,Mus musculus,Armoracia rusticana)
• Mechanisms by which diabetes increases cardiovascular disease (, NA)
• Notch signaling via Deltex (, NA)
• Notching up another pathway (, NA)
• Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus (, Homo sapiens)
• Multiple Pathways of TIMP-1-CD63 signaling (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Danio rerio,Homo sapiens,Bos taurus,Escherichia coli,Betapolyomavirus macacae)
• Sphingosine-1-phosphate receptors and innate immunity (, NA)
• Gdnf signaling pathways within the mammalian spermatogonial stem cell niche (, NA)
• Gdnf signaling pathways within the mammalian spermatogonial stem cell niche (, NA)
• SIRT6 IN DNA REPAIR, METABOLISM, AND AGEING (, NA)
• Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs): Multifunctional proteins in cancer (, NA)
• Effect of AB on CypD-involved mPTP formation (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Emerging concepts for immune checkpoint blockade-based combination therapies (, NA)
• Emerging concepts for immune checkpoint blockade-based combination therapies (, NA)
• Brick by brick: metabolism and tumor cell growth (, NA)
• Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease (, NA)
• Classical and back-door pathways of androgen biosynthesis (, NA)
• Traditional Chinese Medicine in Treatment of Metabolic Syndrome (, NA)
• Traditional Chinese Medicine in Treatment of Metabolic Syndrome (, NA)
• Interaction between two known Egr1 target genes, PTEN and fibronectin achieves a delicate balance between attachment and apoptosis of detached cells (anoikis) (, NA)
• Genes mapped to the IL-6 pathway by IPA Software (, NA)
• Signalling routes emanating from the epidermal growth factor receptor (EGFR) (, NA)
• Prostaglandin E2 as a Regulator of Immunity to Pathogens (, NA)
• For Therapeutic Targeting of AKAP Signaling Complexes in Nervous System Disorders (, NA)
• For Therapeutic Targeting of AKAP Signaling Complexes in Nervous System Disorders (, NA)
• Drug resistance in HER2-positive breast cancer brain metastases: blame the barrier or the brain? (, Homo sapiens,Mus musculus,Mouse mammary tumor virus)
• Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis (, NA)
• Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis (, NA)
• Dysregulation of the Phosphatidylinositol 3-kinase Pathway in Thyroid Neoplasia (, NA)
• Dopaminergic Signaling in Dendritic Spines (, NA)
• Regulation of the Nitric Oxide Pathway Genes by Tetrahydrofurandiols: Microarray Analysis of MCF-7 Human Breast Cancer Cells (, NA)
• Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations (, NA)
• Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations (, NA)
• Hyperglycemia enriches metabolic flux to glycolysis and five principal branches including the polyol pathway, pentose phosphate pathway (PPP), hexosamine pathway, protein kinase C (PKC) pathway, and advanced glycation end-products (AGE) pathway (, NA)
• The molecular pathways and their potential interactions involved during the development of the pyloric sphincter (, Gallus gallus,Homo sapiens)
• Mechanisms of acantholysis in pemphigus (, NA)
• MEK5-ERK5 Signaling in Cancer: Implications for Targeted Therapy (, NA)
• Protein Kinase C: Perfectly Balanced (, Saccharomyces cerevisiae,Croton tiglium,Croton flavens,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Lambdavirus lambda,NA)
• Signaling cascades initiated via TLR2- and TLR4-dependent activation (, NA)
• TIGIT pathway (, NA)
• Sphingolipids and their metabolism in physiology and disease (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces cerevisiae SK1,Homo sapiens,Bos taurus,Caenorhabditis elegans,Human immunodeficiency virus 1,prion)
• Aspects of PRLR signaling as related to mammary gland function (, Homo sapiens)
• Hypothetical scheme illustrates the putative intracellular signaling cascades serving as the context for the data collected in the current study (, Rattus norvegicus,Homo sapiens)
• Models to describe how Ras/PKA signaling activity influences autophagy and how this control might be coordinated with that of the Tor signaling pathway (, NA)
• Purine salvage pathway and HGprt function () (, Homo sapiens)
• WNT SIGNALING PATHWAY: AGING GRACEFULLY AS A PROTECTIONIST? (, NA)
• WNT SIGNALING PATHWAY: AGING GRACEFULLY AS A PROTECTIONIST? (, NA)
• Therapeutic targets for brain injury for nanoparticle mediated drug delivery (, NA)
• Cartoon of two of the most promising DNA repair pathways for cancer therapeutics (, NA)
• Astrocyte glycogen and lactate: new insights into learning and memory mechanisms (, NA)
• Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine (, NA)
• Two branches of TLR downstream signaling (, Mus musculus,Staphylococcus aureus,Homo sapiens)
• GCs stimulate GSK3ß and inhibit Wnt signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR) (, NA)
• Proposed model for PMT action on Gq-mediated mitogenic signaling (, NA)
• Working hypothesis on the mechanism by which plasminogen activator inhibitor-1 (PAI-1) causes hepatic steatosis (, NA)
• Wnt Signaling and Skeletal Development (, NA)
• TOLL-LIKE RECEPTORS REGULATION OF VIRAL INFECTION AND DISEASE (, Homo sapiens,Mus musculus)
• Stress-induced release of eHsp72 (, NA)
• Promiscuous Mutations Activate the Non-Canonical NF-kB Pathway in Multiple Myeloma (, Homo sapiens)
• Diasporin Pathway: a tumor progression-related transcriptional network that predicts breast cancer survival (, Homo sapiens,Mus musculus,vectors)
• Synthesis and breakdown of proteins by amino acids (, NA)
• MUC1-C ACTIVATES POLYCOMB REPRESSIVE COMPLEXES AND DOWNREGULATES TUMOR SUPPRESSOR GENES IN HUMAN CANCER CELLS (, Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• Signaling and bipolar cell reprogramming (, Homo sapiens,Papio anubis,Mus musculus)
• Metabolic pathway of lipid mediator production (, Mus musculus,Homo sapiens)
• Senescence via tumor suppressor pathways (, Homo sapiens,Mus musculus)
• Scratching the surface of skin development (, NA)
• Summary of the signaling pathways involved in hair follicle morphogenesis and regeneration (, NA)
• Catenins: Keeping Cells from Getting Their Signals Crossed (, NA)
• Single-base resolution mapping of 5-hydroxymethylcytosine modifications in hippocampus of Alzheimer’s disease subjects (, Homo sapiens,Mus musculus,Malus domestica)
• Progesterone-induced neuroprotective signaling (, NA)
• Interferon system (, Dengue virus,H1N1 subtype,Zika virus,West Nile virus,Dengue virus type 2,Dengue virus group,Dengue virus type 3,Homo sapiens,Macaca mulatta,Aedes aegypti,Aedes albopictus,Mus musculus,clinical samples)
• Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases (, NA)
• Interactions between cellular metabolism, the circadian molecular clock, and ion channels (, NA)
• Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle (, NA)
• P53 on the IGF-1 signaling pathway (, NA)
• Networks of pathways unique in the HIV-1 regulated mPBMCs (, Homo sapiens,Human immunodeficiency virus 1,Simian immunodeficiency virus,Macaca nemestrina)
• TGFB1-induced PAI-1 expression in VSMC (, Mus musculus,Rattus norvegicus,Adenoviridae,Homo sapiens)
• Comprehensive Review of Genetic Factors Contributing to Head and Neck Squamous Cell Carcinoma (HNSCC) Development in Low-Risk, Non-Traditional Patients (, Human papillomavirus,Human papillomavirus type 16,Homo sapiens,Nicotiana tabacum)
• GCN5L1/BLOS1 links acetylation, organelle remodeling and metabolism (, NA)
• Intermittent metabolic switching, neuroplasticity and brain health (, NA)
• Intermittent metabolic switching, neuroplasticity and brain health (, NA)
• Aging of the brain, neurotrophin signaling, and Alzheimer’s disease: is IGF1-R the common culprit? (, NA)
• Some signaling pathways that could mediate long-term changes in cellular plasticity as a function of sexual experience (, NA)
• Androgen actions via intracellular androgen receptor mediated pathways (, NA)
• Heterogeneity of Pacemaking Ability among SCN Neurons Robust rhythm generation in SCN neurons (, Homo sapiens)
• Thy-1-associated signaling pathways (, Mus musculus,Homo sapiens)
• Involvement of IRAK-2, M, and 4 in the differential regulation of NFkB pathway (, Homo sapiens)
• Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types (, Diaporthe sclerotioides,Eucalyptus intertexta,Erythroxylum coca,Homo sapiens,Calloplesiops altivelis)
• BDNF enhancement of glutamate-induced phase shifting in the SCN, and potential locations in the signaling pathway where ethanol could inhibit this process (, NA)
• Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade (, NA)
• Human T-Cell Leukemia Virus Type 1 Blunts Signaling by Interferon Alpha (, Human T-cell leukemia virus type I)
• Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics (, Homo sapiens)
• Epidermal Growth Factor Stimulates RSK2 Activation through Activation of the MEK/ERK Pathway and Src-dependent Tyrosine Phosphorylation of RSK2 at Tyr-529 (, NA)
• Possible role of GPCR oligomerization in arrestin-mediated signaling (, NA)
• Folate and one-carbon metabolic pathway (, NA)
• NEC pathophysiology is a complex series of events leading to a final common pathway of inflammation (, NA)
• Development and Connectivity of the Habenular Nuclei (, NA)
• Summary of known actions of activated ras-p21 in cells, beginning (top, left) when a growth factor binds to its cell receptor (, NA)
• Triggering and amplification of the Wnt/Beta-catenin pathway in osteocytes in response to load (, NA)
• Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges (, Homo sapiens,Mus musculus,gut metagenome,Mouse mammary tumor virus)
• Using gene expression data to direct breast cancer therapy: Evidence from a pre-clinical trial (, NA)
• Integration of Progesterone Receptor Action with Rapid Signaling Events in Breast Cancer Models (, NA)
• Schematic depicting the effect of the PI3-K/Akt pathway and the JNK pathway on Bad activation in the peripheral area after brain ischemia/reperfusion injury and pharmacological manipulation (, NA)
• Multiple roles of chemokine CXCL12 in the central nervous system: A migration from immunology to neurobiology (, NA)
• Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation (, NA)
• Dmp1 links the Rb and p53 pathways (, NA)
• Reactive Oxygen Species in Metabolic and Inflammatory Signaling (, NA)
• Canonical Wnt signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis)
• Noncanonical Wnt signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis)
• Wnt/TOR and Wnt/STOP signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Lareunionomyces loeiensis)
• Rapid Signaling Mechanisms of Estrogens in the Developing Cerebellum (, NA)
• PARP inhibition mechanism of action—blockade of the base excision pathway (, NA)
• Cytokine-Effects on Glucocorticoid Receptor Function: Relevance to Glucocorticoid Resistance and the Pathophysiology and Treatment of Major Depression (, NA)
• P. gingivalis accelerates gingival epithelial cell progression through the cell cycle (, NA)
• Combinatorial signalling by TGFB1 of the inducible activation of FAK and AKT in anoikis-resistant myofibroblasts (, NA)
• RGC death induced by glaucomatous stimuli involves receptor-mediated caspase activation, and caspase-dependent and -independent components of the mitochondrial cell death pathway (, Homo sapiens)
• MSC PGE2 secretion reprograms M1 via two independent pathways to M2 macrophages (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Escherichia coli)
• Metabolomics Applied to Islet Nutrient Sensing Mechanisms (, NA)
• Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis (, NA)
• Diagrammatic representation of insulin on growth factor signaling through the Ras-Raf, MEK-ERK signaling pathway with downstream effects on gene transcription through ERK translocation (, NA)
• Intracellular Signaling in Insulin-mediated Regulation of Drug Metabolizing Enzyme Gene and Protein Expression (, NA)
• Insulin-mediated activation of PI3K signaling pathways (, NA)
• Diagram showing several factors involved in lens development (, NA)
• MAPK pathway alterations in melanoma (, Mus musculus,Homo sapiens)
• SARS CORONAVIRUS AND INNATE IMMUNITY (, Severe acute respiratory syndrome coronavirus 2,Influenza A virus,Coronaviridae,Severe acute respiratory syndrome-related coronavirus,Vaccinia virus,Ebola virus,Measles morbillivirus,Murine hepatitis virus,Human coronavirus 229E,Infectious bronchitis virus,Transmissible gastroenteritis virus,Zaire ebolavirus,Homo sapiens,Chlorocebus aethiops,Mus musculus,NA,NA,NA,NA,NA,NA)
• PI3K/AKT/mTOR pathway (, Mus musculus,Homo sapiens)
• DNA replication and damage checkpoint regulation (, NA)
• The strategy for identifying Ub modification sites in protein targets and for analyzing polyUb chain topologies (, NA)
• Keratinocyte Apoptosis in Epidermal Development and Disease (, Mus musculus,Homo sapiens)
• Keratinocyte Apoptosis in Epidermal Development and Disease (, Mus musculus,Homo sapiens)
• ESTABLISHMENT OF SPEMANN’S ORGANIZER AND PATTERNING OF THE VERTEBRATE EMBRYO (, NA)
• ESTABLISHMENT OF SPEMANN’S ORGANIZER AND PATTERNING OF THE VERTEBRATE EMBRYO (, NA)
• Mitochondrial pathway through Bcl-2 family members (, NA)
• The Stat pathway (, NA)
• Pan-cancer molecular classes transcending tumor lineage across 32 cancer types, multiple data platforms, and over 10,000 cases (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Mechanical strain induced phospho-proteomic signaling in uterine smooth muscle cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Sequoia sempervirens)
• Schematic illustration of the principal signaling pathways that are affected by sodium arsenite (As) treatment (, Homo sapiens,Mus musculus)
• Nucleotide excision repair pathway (, NA)
• TAK1 is a central mediator of NOD2 signaling in epidermal cells (, NA)
• Intracellular Signaling via ERK/MAPK Completes the Pathway for Tubulogenic Fibronectin in MDCK Cells (, NA)
• Drugs that regulate hepatic bile acid and other organic solute uptake, synthesis, detoxification and secretion (, NA)
• Glycogen Synthase Kinase-3 (GSK3) in Psychiatric Diseases and Therapeutic Interventions (, NA)
• FIP200, a key signaling node to coordinately regulate various cellular processes (, NA)
• CaMK/BPIX signaling pathway (, Rattus norvegicus,Agaricus bisporus,Homo sapiens)
• Pharmokinetic Limitations of Antioxidant Treatment for COPD (, Homo sapiens)
• Oncogene-induced genomic instability (, NA)
• Plasmacytoid dendritic cells and type I IFN: 50 years of convergent history (, NA)
• Proliferation induced by androgen independent pathways (, NA)
• Steroid receptor expression in postnatal day 5–10 developing prostates from oil-treated control rats (A) and neonatally estrogenized rats (B) (, NA)
• Race disparities in the contribution of miRNA isoforms and tRNA-derived fragments to triple-negative breast cancer (, NA)
• Proposed model for the activation of oligodendrocyte apoptosis by MHV infection (, NA)
• GSK-3B Targets Cdc25A for Ubiquitin-Mediated Proteolysis and GSK-3B Inactivation Correlates with Cdc25A Overproduction in Human Cancers (, Homo sapiens,Mus musculus)
• 5-HT2A receptor agonists cause activation of GAq/11 proteins which in turn activate the second messenger enzyme PLC (, NA)
• Type 1 diabetes pathogenesis and B cell protective factors (, Homo sapiens,Mus musculus)
• Ghrelin and the Growth Hormone Secretagogue Receptor Constitute a Novel Autocrine Pathway in Astrocytoma Motility (, NA)
• Simplified schematic diagram showing putative regulation of B (, Biomphalaria glabrata,Homo sapiens)
• Finally, expression of T-cell co-stimulatory and co-inhibitory receptors can be modulated by hypoxia as well (, NA)
• Heterotypic RPE-choroidal endothelial cell contact increases choroidal endothelial cell transmigration via PI 3-kinase and Rac1 (, NA)
• Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration (, NA)
• TrkB-mediated activation of the phosphatidylinositol-3-kinase/Akt cascade reduces the damage inflicted by oxygen-glucose deprivation in area CA3 of the rat hippocampus (, NA)
• Schematic diagram showing the major components that control [Ca2+]i in myometrium (, NA)
• Life and death decisions by the E2F transcription factors (, NA)
• Life and death decisions by the E2F transcription factors (, NA)
• Cell injury to wound closure, including P2Y activation, intracellular Ca2+ release and EGFR signaling (, Homo sapiens)
• Signal-transduction events in necroptosis (, NA)
• Schematic outline of the involvement of necroptosis in elimination of cells of the cardiovascular system and reported inhibition strategies based on necroptosis pathway (, NA)
• Signaling pathways downstream of adiponectin in cells of the cardiovascular system (, NA)
• Review of craniofacial and dental findings of the RASopathies (, Canis lupus familiaris,Panthera pardus,Homo sapiens)
• Structure of FAK (, NA)
• Plasticity of myeloid-derived suppressor cells in cancer (, Homo sapiens,Mus musculus,Candida dubliniensis,Listeria monocytogenes)
• Hepatic and Renal Metabolism and Toxicity of Trichloroethylene and Perchloroethylene by Alterations in Status of Cytochrome P450 and Glutathione (, NA)
• Intracellular signaling cascades activated by BDNF-stimulated autophosphorylation of TrkB receptors may affect prominent pathways responsible for elevations of intracellular Ca2+ levels in neurons (, NA)
• Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain (, NA)
• Hypothetical role of Hsp72 in the regulation of oxidative stress-induced HMGB1 cytoplasmic translocation and release (, Mus musculus,Homo sapiens)
• Schematic presentation of the NFKB signaling network in radiation-induced adaptive radioresistance (, Homo sapiens)
• Schematic illustration of NGF activation of KOR P2 during RA-induced neuronal differentiation of P19 (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Metformin as a Tool to Target Aging (, NA)
• RPMT signaling pathways in cardiomyocytes (, NA)
• THE INFLAMMATORY RESPONSE IN STROKE (, NA)
• Canonical Wnt Signaling Pathway (, NA)
• Prototypical myelin-derived neurite growth inhibitors, their receptors and intracellular signaling pathway (, Homo sapiens)
• Manipulating the PD-1 pathway to improve immunity (, Human alphaherpesvirus 1,Vaccinia virus,Simian immunodeficiency virus,Homo sapiens,Macaca mulatta,Mus musculus,Schistosoma mansoni,Histoplasma capsulatum,NA,NA)
• Manipulating the PD-1 pathway to improve immunity (, Human alphaherpesvirus 1,Vaccinia virus,Simian immunodeficiency virus,Homo sapiens,Macaca mulatta,Mus musculus,Schistosoma mansoni,Histoplasma capsulatum,NA,NA)
• Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and its Agonists (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa)
• Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells (, Homo sapiens,Mus musculus)
• Pathways for the synthesis of the major phospholipids in S (, Saccharomyces cerevisiae,Homo sapiens)
• To Eat or Not to Eat – The Metabolic Flavor of Ferroptosis (, Homo sapiens,Mus musculus,Caenorhabditis elegans)
• Deciphering p53 Signaling in Tumor Suppression (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Focal Adhesions Regulate AB Signaling & Cell Death in Alzheimer’s Disease (, NA)
• Anti-apoptotic pro-survival signaling mechanisms, termed the reperfusion injury salvage kinase (RISK) pathway, that have been proposed to protect the heart from reperfusion injury (, NA)
• Network of metabolic pathways that regulate leukemia (, Homo sapiens,Macaca mulatta,Mus musculus)
• Identified pathway between EGFR and JUN for Loi’s breast cancer dataset (, Homo sapiens,Saccharomyces cerevisiae,Simian retrovirus 2)
• HIF-1A pathway and creation of an HIF-1A knockout mouse model (, NA)
• Insulin/IGF-1 signalling map (, NA)
• Role of nitric oxide (NO) and peroxynitrite in cardiovascular pathophysiology (, Homo sapiens)
• Mitogen-activated protein kinase (MAPK) signaling and stimulating effects of peroxynitrite (, Homo sapiens)
• Cardiovascular dysfunction in diabetes: role of superoxide and peroxynitrite (, Homo sapiens)
• Wnt-Frizzled signaling pathway regulates PS exposure and apoptosis (, NA)
• Membrane asymmetry in neuronal and vascular systems (, NA)
• TUNING IMMUNE TOLERANCE WITH VASOACTIVE INTESTINAL PEPTIDE: A NEW THERAPEUTIC APPROACH FOR IMMUNE DISORDERS (, NA)
• Inflammation and Insulin Resistance (, NA)
• Obstructive nephropathy: insights from genetically engineered animals (, Homo sapiens)
• Targeting Autophagy in Cancer (, NA)
• Scheme depicting a molecular pathway by which cell-cycle-related molecules promote cell death in neurons in development and disease (, NA)
• Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer (, NA)
• Histamine H3-Receptor Signaling in Cardiac Sympathetic Nerves: Identification of a Novel MAPK-PLA2-COX-PGE2-EP3R Pathway (, Cavia porcellus,Homo sapiens)
• Inhibition of COX-2 modulates multiple functional pathways during acute inflammation and pain (, NA)
• MOLECULAR AND CELLULAR MECHANISMS OF THE ANABOLIC EFFECT OF INTERMITTENT PTH (, NA)
• Oxidative stress initiates a cascade of reactions leading to cell death via one or more sequences of molecular events (, Homo sapiens)
• BACTEROIDES FRAGILIS TOXIN COORDINATES A PRO-CARCINOGENIC INFLAMMATORY CASCADE VIA TARGETING OF COLONIC EPITHELIAL CELLS (, NA)
• Working model for Eph receptor function in tumor promotion and tumor suppression (, NA)
• Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions (, NA)
• Colorectal cancer prevention: immune modulation taking the stage (, NA)
• RA synthesis pathway (, Homo sapiens)
• MAPK pathway in BRAF-mutant melanoma (, NA)
• Fumarate accumulation, HIF-1A regulation, and glycolysis in renal cells with increased intracellular glucose (, NA)
• MAPK pathway bypass in melanoma (, NA)
• Hedgehog Signaling In Liver Pathophysiology (, NA)
• Filoviruses inhibit the type I IFN response at multiple steps (, NA)
• FAK FERM-mediated p53 turnover and cell survival (, Homo sapiens,Mus musculus)
• Multiple ERK scaffold regulate growth factor and adhesion signaling (, NA)
• New Opportunities and Challenges to Defeat Cancer Stem Cells (, NA)
• Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3 (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Signaling pathways that regulate Drosophila metabolism (, NA)
• Ca2+ mobilization and Ca2+ removal mechanisms in VSM (, NA)
• Schematic representation showing the plausible signaling events from uPAR integrin complex (, Homo sapiens)
• Cardiovascular dysfunction in diabetes: role of superoxide and peroxynitrite (, NA)
• Proposed role of the oxidative and nitrosative stress–poly(ADP-ribose) polymerase 1 (PARP-1) pathway in oxidant-induced cellular dysfunction and necrosis (, NA)
• Function of JNK/SAPK scaffolds in organizing the MKKK-MKK4/MKK7- JNK signaling module (, Homo sapiens,Rattus norvegicus)
• Role of Oxidative-Nitrosative Stress and Downstream Pathways in Various Forms of Cardiomyopathy and Heart Failure (, Homo sapiens)
• Peroxynitrite-mediated interference with the NFKB pathway (, Homo sapiens,Rattus norvegicus)
• NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential (, NA)
• Illustration of cross-communication network of BCR, PI3K, and NFKB signaling pathways that harbor effective therapeutic targets in lymphoma (, Homo sapiens)
• Illustration of JAK/STAT signaling pathway that inspires effective therapeutic targets in lymphoma (, Homo sapiens)
• Apoptosis signaling pathway that contains effective therapeutic targets in lymphoma (, Homo sapiens)
• PD-1/PD-Ls signaling pathway that acts as effective therapeutic targets in lymphoma (, Homo sapiens)
• Molecular targets for therapy in the HH pathway web of collaboration (, NA)
• Glutamine/Glutamate (GLN/GLU) cycle in neurons and astrocytes (, NA)
• Nonhuman primate kidney transcriptome in fetal development (, NA)
• PI3K/AKT/mTOR signaling pathway (, Homo sapiens,Mus musculus)
• Polarization of the EMS cell and the T cell (, Homo sapiens,Caenorhabditis elegans)
• Oval of iNOS-inducing signaling pathways (, NA)
• Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism (, NA)
• Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Drosophila melanogaster,prion,Streptococcus pyogenes)
• Mechanisms of Action of GLP-1 in the Pancreas (, NA)
• Schema outlining the signaling mechanisms reported to be involved in GLP-1R-induced differentiation/neogenesis of pancreatic precursor cells, proliferation and in the prevention of apoptosis (, NA)
• Advances in combating fungal diseases (, NA)
• Models for the dual roles of KLF4 and KLF5 in tumor suppression and oncogenesis (, NA)
• Blocks of iNOS-blocking signaling pathways (, NA)
• Proposed model of an energy balance-responsive network associated with DNMT1 regulation, DNA methylation and transcriptional regulation of ERA and ERB (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Armoracia rusticana,Helicobacter pylori,Mouse mammary tumor virus)
• Functional interacteome of all parietal cortex proteins (, NA)
• Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src (, NA)
• Notch signaling pathway (, NA)
• Mitochondrial energetics in the kidney (, NA)
• Nm23-H1 in cell cycle regulation and apoptosis (, NA)
• Signaling mechanisms involved in lifespan regulation and the cellular response to genotoxic stress (, NA)
• AUTOPHAGY: HIGHLIGHTING A NOVEL PLAYER IN THE AUTOIMMUNITY SCENARIO (, NA)
• Cocaine evokes a profile of oxidative stress and impacts innate antiviral response pathways in astrocytes (, Human immunodeficiency virus 1,Human immunodeficiency virus,Zika virus,Aurantiochytrium single-stranded RNA virus 01,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Rattus norvegicus,Gallus gallus,prion,Leishmania amazonensis)
• Regulation of gap junction coupling through the neuronal connexin Cx35 by nitric oxide and cGMP (, NA)
• Signaling during SMC phenotype switching (, NA)
• Co-coculture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells (, NA)
• Apoptotic signaling during SMC response to injury (, NA)
• illustrates the possible mechanisms that underlie VIP’s actions in SCN neurons (, Homo sapiens,Drosophila melanogaster)
• Adenylyl cyclases are targets of multiple regulatory signaling pathways and respond differently, depending on which group they belong to (, NA)
• Checkpoints activated upon rereplication (, Homo sapiens,Mus musculus)
• Ischemic/hypoxic effects on cardiac myocytes and stem cells (, NA)
• Role of Lipids in Brain Injury and Diseases (, NA)
• Beta Adrenergic Receptors in Keratinocytes (, NA)
• Signaling on the endocytic pathway (, NA)
• Signaling mechanisms for the activation of HAT and HDAC (, NA)
• TLR4 initiated and cAMP mediated abrogation of bacterial invasion of the bladder (, Escherichia coli,Klebsiella pneumoniae,Mus musculus,Homo sapiens)
• Interaction map of the Notch signaling pathway (, NA)
• Representation of the dual effects of zinc in Bax-associated induction of mitochondrial apoptogenesis in malignant prostate cells (, Homo sapiens,Mus musculus)
• Chordin gene regulation in the zebrafish gastrula (, Homo sapiens,Danio rerio)
• Developmental Exposure to Environmental Endocrine Disruptors: Consequences within the Ovary and on Female Reproductive Function (, NA)
• ZIP1 expression and zinc accumulation in the pathway and bioenergetics of citrate production and citrate oxidation in normal versus malignant prostate cells (, Homo sapiens,Mus musculus)
• TGFB SIGNALING BY PROINFLAMMATORY CYTOKINES IN ARTICULAR CHONDROCYTES (, Homo sapiens,Bos taurus,Sequoia sempervirens)
• Immune Response and Cell Cycle Networks (, NA)
• Proline-Rich Tyrosine Kinase 2 Mediates Gonadotropin-Releasing Hormone Signaling (, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Armoracia rusticana,Triticum aestivum,Homo sapiens,Corynephage beta)
• Putative vasoactive signaling pathways involved in neurovascular coupling (, NA)
• Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system (, NA)
• Cellular Prion Protein (PrPC): Its Physiological Function and Role in Disease (, NA)
• Regulation of cell proliferation and cell death by PKCE (, NA)
• Ins (endocytosis) and Outs (exocytosis) of GLUT4 Trafficking (, NA)
• Regulation of CXCR4 Signaling (, NA)
• Functional Foods for Augmenting Nitric Oxide Activity and Reducing the Risk for Salt-Induced Hypertension and Cardiovascular Disease in Japan (, NA)
• Model showing a role for Yap in governing cardiac growth and survival by interlinking the Hippo, IGF, and Wnt pathways (, NA)
• Progesterone regulated paracrine signaling model depicted within the uterine compartments at the time of embryo implantation (, NA)
• Nodal signaling pathway in melanoma (, NA)
• Cytokine Combination Therapy Prediction for Bone Remodeling in Tissue Engineering Based on the Intracellular Signaling Pathway (, NA)
• Complement and dysbiosis in periodontal disease (, Escherichia coli,Porphyromonas gingivalis,Bacillus anthracis,Treponema denticola,Tannerella forsythia,Prevotella intermedia,Homo sapiens,Macaca fascicularis,Mus musculus,Equus caballus,Triportheus paranensis)
• P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation (, NA)
• The role of Wnt signaling in hypothalamic progenitor differentiation (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Zea mays,unidentified)
• Alzheimer’s Disease pathway from KEGG (, NA)
• Additional analysis of the PPI network (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Matthiola incana,Homo sapiens,Mus musculus,Oryctolagus cuniculus,vectors,Epinnula magistralis,NA)
• TAP-MS PPI RTK-Ras-ERK signaling network (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Matthiola incana,Homo sapiens,Mus musculus,Oryctolagus cuniculus,vectors,Epinnula magistralis,NA)
• Possible cellular responses and transcriptional regulation initiated by activation of opioid receptor signaling (, NA)
• Proposed model for the involvement of NFKB signaling in opioid receptor-expressing immune and neuronal cells (, NA)
• Putative microRNAs identified to regulate gene expression in the PGE2pathway (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Drosophila melanogaster)
• Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease (, NA)
• A, in hormone-dependent ER+ breast cancer cells, estrogen (E2) activates ER-mediated transcription (genomic pathway) and nongenomic ER-mediated signaling (, Homo sapiens)
• Choreography of Ca2+signaling and examples of virus-induced perturbations on Ca2+ homeostasis (, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Respiratory syncytial virus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Enterovirus C,Betapolyomavirus macacae,Human alphaherpesvirus 2,Coxsackievirus B3,Human alphaherpesvirus 3,Coxsackievirus,Murine hepatitis virus,Tobacco mosaic virus,Simian immunodeficiency virus,Polyomavirus sp.,Human rhinovirus sp.,Suid alphaherpesvirus 1,Influenza B virus,Papaya ringspot virus,Human T-cell lymphotropic virus,Bovine alphaherpesvirus 1,Bluetongue virus,Rubella virus,Poliovirus 2,Deltapapillomavirus 4,Turnip crinkle virus,Bovine ephemeral fever virus,Human respirovirus 1,Human rhinovirus 1A,Equid alphaherpesvirus 1,African horse sickness virus,rhinovirus B3,Feline panleukopenia virus,Rat coronavirus,rhinovirus B14,Avian polyomavirus,Goat enterovirus,Beet yellow stunt virus,Cocksfoot mottle virus,Nicotiana tabacum,Citrus limon,Corynebacterium phage gamma,Sinsheimervirus phiX174,Homo sapiens,Rattus norvegicus,Escherichia coli,Canis lupus familiaris,NA,NA,NA)
• Illustration of the metabolic pathway analysis for zidovudine with thick arrows indicating targets identified by the automatic classifier (, NA)
• Interferon-Gamma-induced glial cell activation by transforming growth factor B1: A role for STAT1 and MAPK pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• ATM signaling upon oxidative stress and double-strand DNA breaks (, NA)
• Schematic respresentation of anterograde and retrograde trafficking pathways for KCa2.x (left) and KCa3.1 (right) channels (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Canis lupus familiaris,Xenopus laevis)
• Insulin Resistance and Heart Failure: Molecular Mechanisms (, NA)
• Integration of B cell responses through Toll-like receptors and antigen receptors (, NA)
• Glutathione and modulation of cell apoptosis (, NA)
• Glutathione and modulation of cell apoptosis (, NA)
• The MAPK cascade activation and potential cross talk signals (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,unidentified virus)
• HIF target genes encode proteins involved in critical aspects of cancer progression (, Homo sapiens,Mus musculus)
• Neuronal and extraneuronal release of ATP and NAD+ in smooth muscle (, NA)
• Docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and 16O/18O labeling (, NA)
• Regulation of mammalian target of rapamycin complex (mTORC) signaling networks (, NA)
• The zonulin mechanism of action (, Homo sapiens,Rattus norvegicus,Triticum aestivum,Vibrio cholerae)
• HER2 overexpression renders human breast cancers sensitive to PARP inhibition independently of any defect in homologous recombination DNA repair (, Homo sapiens,Mus musculus,Bos taurus)
• Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with Sorafenib (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Glycine max)
• Cell-Intrinsic Innate Immune Control of West Nile Virus Infection (, NA)
• Network analysis suggests an immune response and inflammation in ulcerative tissue and non-ulcerative tissue of patients with ulcerative interstitial cystitis (IC) (, Homo sapiens,Rattus norvegicus)
• Blastocyst Lineage Segregation and Stem Cells (, Mus musculus,Rattus norvegicus,Microtus arvalis,Homo sapiens,Bos taurus,Diaporthe sclerotioides)
• Mosquito immune defenses against Plasmodium infection (, NA)
• The signaling pathways involved in T-cell activation (, NA)
• Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets (, Mus musculus,Rattus norvegicus,Homo sapiens,Woolly monkey sarcoma virus,NA)
• Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets (, Mus musculus,Rattus norvegicus,Homo sapiens,Woolly monkey sarcoma virus,NA)
• Aberrant activation of the MAPK signaling pathway in papillary thyroid tumor cells (, NA)
• Crowdsourcing Network Inference: The DREAM Predictive Signaling Network Challenge (, Homo sapiens,Sequoia sempervirens)
• Network analysis of proteins found to be significantly altered in abundance in the CSF proteome by ANOVA (p value <0.05) following analysis of individual subject samples (, Borreliella burgdorferi,Borreliella burgdorferi B31,Borreliella garinii,Homo sapiens,Mus musculus)
• Age-related alterations in receptors and signaling molecules of CD8 T cells (, Homo sapiens,Mus musculus,Respiratory syncytial virus)
• RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Nrf2 as a Chemopreventive Target in Colorectal Cancer (, Panax ginseng,Curcuma longa,Brassica oleracea,Homo sapiens,Mus musculus,Rattus norvegicus,Pan troglodytes,Canis lupus familiaris,Tringa semipalmata)
• Complement-targeted therapeutics in periodontitis (, Staphylococcus aureus,Porphyromonas gingivalis,Homo sapiens,Mus musculus)
• Emerging Roles for Cholesterol and Lipoproteins in Lung Disease (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mycobacterium tuberculosis,Klebsiella pneumoniae,Homo sapiens,Oryctolagus cuniculus,Dermatophagoides farinae)
• BOLERO-2 trial: the addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer (, Homo sapiens)
• Mechanism of Sirt1activation by RSV (, NA)
• Regulatory network analysis of the top genes with SNPs with p<0.001 using MetaCore’s shortest pathway algorithm (GeneGo Inc.); the nodes that are circled are the genes of interest (, NA)
• Multiple roles of COUP-TFII in cancer initiation and progression (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus,Argopecten nucleus)
• Large scale phosphoproteome analysis of LNCaP human prostate cancer cells (, Homo sapiens,Bos taurus,Lareunionomyces loeiensis)
• HER2 activation (, NA)
• General mechanisms of resistance to trastuzumab: presence of upregulation of HER2 downstream signaling pathways (, NA)
• General mechanisms of resistance to trastuzumab: presence of signaling through an alternate receptor and/or pathway (, NA)
• Involvement of the target of rapamycin (mTOR) pathway in human disease syndromes (, NA)
• Transmembrane CLRs involved in antifungal immunity and their intracellular signaling pathways (, Saccharomyces cerevisiae,Candida albicans,Aspergillus fumigatus,Cryptococcus neoformans,Alternaria alternata,Paracoccidioides brasiliensis,Pneumocystis carinii,Blastomyces dermatitidis,Fonsecaea pedrosoi,Homo sapiens,Mus musculus,Escherichia coli)
• MAPK and NFKB signaling pathways (, NA)
• Proposed model for mitohormesis in response to reduced insulin/IGF1-signaling.A (, NA)
• HIV’s double strike at the brain (, NA)
• MTORC1 signaling and genetic mutations at specific sites in the pathway (, Oryctolagus cuniculus,Capra hircus,Equus caballus,Homo sapiens,Mus musculus,Avian myeloblastosis virus)
• Nongenomic and genomic estrogen signaling pathways (, NA)
• mAKAPB coordinates hypertrophic signaling leading to cardiac gene remodeling (, NA)
• Schematic illustrating metabolic pathways prominent in malignant cells (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• As a key downstream target of PI3K-mediated signaling pathway in response to extracellular stimuli such as growth factors through receptor tyrosine kinase (RTK), Akt plays an important role in regulation of diverse cellular processes (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Metformin, an anti-diabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway (, Armoracia rusticana,Nicotiana tabacum,Homo sapiens,Mus musculus,Bos taurus)
• The Ras→Raf→MEK1/2→ERK1/2 signalling pathway (, Homo sapiens,Mus musculus,NA)
• Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (, Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Cytokinesis Mechanics and Mechanosensing (, Caenorhabditis elegans,Paracentrotus lividus,Dictyostelium discoideum,Homo sapiens,Schizosaccharomyces pombe)
• Schematic diagrams of the role of STAT1 in antimycobacterial, antiviral and antifungal immunity (, NA)
• Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease (, NA)
• Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act (, NA)
• Metabolic Actions of Angiotensin II and Insulin: A Microvascular Endothelial Balancing Act (, NA)
• Emerging role of nuclear architecture in DNA repair and genome maintenance (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Prognostic Value of Cell-Cycle Regulation Biomarkers in Bladder Cancer (, NA)
• Yeast Saccharomyces cerevisiae: A Versatile Model System for the Identification and Characterization of Bacterial Virulence Proteins (, Saccharomyces cerevisiae,Homo sapiens)
• SHEDDING NEW LIGHT ON NEURODEGENERATIVE DISEASES THROUGH THE MAMMALIAN TARGET OF RAPAMYCIN (, NA)
• SHEDDING NEW LIGHT ON NEURODEGENERATIVE DISEASES THROUGH THE MAMMALIAN TARGET OF RAPAMYCIN (, NA)
• SOCS1 regulates the IFN but not NFKB pathway in TLR-stimulated human monocytes and macrophages (, Oryctolagus cuniculus,Capra hircus,Equus asinus,Homo sapiens,Mus musculus,Influenza A virus)
• Apigenin Inhibits NNK-induced Focal Adhesion Kinase Activation in Pancreatic Cancer Cells (, NA)
• Wnt signaling cascadesWnt signals can be transduced either through the canonical pathway (colored in pink) or different non-canonical pathways (, NA)
• Neurotrophin Regulation of Energy Balance in the Adult CNS and PNS (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Pathway related to prostate cancer (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• HLA-I antibodies stimulate intracellular signals via integrin B4 in endothelial cells and smooth muscle cells in the setting of transplant atherosclerosis (, NA)
• Optimizing treatments for lymphangioleiomyomatosis (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Therapeutic Mechanisms of Treatment in Cervical and Vaginal Cancer (, NA)
• Direct Signaling Between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis (, NA)
• SCOP localization within the neuron (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Immune-Neuroendocrine Integration at the Adrenal Gland: Cytokine Control of the Adrenomedullary Transcriptome (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• Metabolic flux through the purine salvage pathway in L (, NA)
• Characterization of c-Kit expression and activation in KSHV-infected endothelial cells (, NA)
• Cancer Cell Metabolism: One Hallmark, Many Faces (, NA)
• Signaling pathways for estrogen production and action (, Homo sapiens,Mus musculus,Equus caballus,Mouse mammary tumor virus)
• Schematic representation which shows possible mechanisms of action by D- and Gamma-tocopherol in multiple signaling pathways involved in mammary carcinogenesis (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Mouse mammary tumor virus,Trichogramma alpha)
• CYTOPROTECTIVE PROTEIN C PATHWAYS AND IMPLICATIONS FOR STROKE AND NEUROLOGICAL DISORDERS (, Mus musculus,Rattus norvegicus,Escherichia coli,Pseudomonas aeruginosa,Homo sapiens,Oryctolagus cuniculus)
• Inflammatory Bowel Disease (, NA)
• Interface between hemostasis and adaptive immunity (, Staphylococcus aureus,Listeria monocytogenes,Homo sapiens,Mus musculus)
• Calcium regulation of keratinocyte differentiation (, Corynephage beta,Corynebacterium phage gamma,Homo sapiens,Mus musculus,Bos taurus,Cerobasis alpha)
• Distinct signaling pathways of synaptic and extrasynaptic NMDAR in neuron fate (, NA)
• Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Daphnia pulex,Homo sapiens,Canis lupus familiaris,Streptomyces hygroscopicus)
• Interplay between FOXO, TOR, and Akt (, NA)
• Akt isoforms and glucose homeostasis - the leptin connection (, NA)
• GH-STAT5 signaling pathway (, NA)
• Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal (, Homo sapiens,Mus musculus)
• Stem cell pathways analysis for label-retaining cancer cell (LRCC) (, NA)
• AB oligomers stimulate oxidative/nitrosative pathways involving NMDA receptor, nNOS and NADPH oxidase leading to production of ROS and activation of cPLA2 (, Mus musculus,Rattus norvegicus,Homo sapiens,prion,Ginkgo biloba)
• Termination steps during IgE-mediated activation (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Arachis hypogaea,NA)
• Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity (, Mus musculus,Candida dubliniensis,Homo sapiens)
• Cellular Targeting in Autoimmunity (, NA)
• Synergistic cancer cell death in response to stress when TSC2, but not Pten is inactivated in the context of a deregulated Rb pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Human papillomavirus)
• A) Model of the proposed function of dnlg1 in the regulation of synaptic growth and activity in the neuromuscular junction based on the analysis of loss of function and gain of function mutants (, NA)
• Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function (, NA)
• Model illustrating CD40-induced signals that mediate the expression of VEGF in endothelial cells (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Bikinia letestui)
• Estradiol membrane signaling induces spinogenesis in the ARH (, NA)
• Cancer Stem Cells (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Regulation of CSCs by inflammatory cytokine networks (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Conducting the G-protein Coupled Receptor (GPCR) Signaling Symphony in Cardiovascular Diseases: New Therapeutic Approaches (, NA)
• Hippo signaling in Drosophila: recent advances and insights (, NA)
• TARGETING THE INTRAGRAFT MICROENVIRONMENT AND THE DEVELOPMENT OF CHRONIC ALLOGRAFT REJECTION (, NA)
• Chondroitin sulfate proteoglycan 4 (CSPG4) Signaling Pathways (, NA)
• The crosstalk between classical and non-classical mechanisms in female reproductive behavior (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Homo sapiens,Gallus gallus,Symphonia globulifera)
• The activity of PI3K signaling pathway in normal and tumor cells (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Activity of Wnt canonical signaling pathway in the normal and tumor cells (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Targeting a Common Collaborator in Cancer Development (, Homo sapiens,Mus musculus)
• Wnt transduction pathways and their functions during synapse development, function and plasticity (, NA)
• WNTs tune up the neuromuscular junction (, Gallus gallus,Danio rerio,Phoenicopterus roseus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Canis lupus familiaris)
• FoxM1 and WntBeta-catenin Signaling in Glioma Stem Cells (, Homo sapiens,Mus musculus,Xenopus laevis,Lareunionomyces loeiensis,Human papillomavirus type 16)
• Trafficking of DSL ligands and the Notch receptor to and from the plasma membrane of both signal sending cells and signal-receiving cells control activation of the pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Molecular Pathways: The Metabolic Regulator Estrogen-Related Receptor Alpha as a Therapeutic Target in Cancer (, NA)
• Two different pathways could bypass DNA damage causing stalled replication forks (, NA)
• Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• EphrinB reverse signaling (, NA)
• Cholesterol Accumulation Regulates the Expression of Macrophage Proteins Implicated In Proteolysis and Complement Activation (, Homo sapiens,Mus musculus)
• Wnt signaling pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Dipturus trachyderma)
• Expression and mutation analyses implicate ARHGAP29 as the etiologic gene for the cleft lip with or without cleft palate locus identified by genome wide association on chromosome 1p22 (, NA)
• Signaling pathways for longevity (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Signaling pathways for longevity (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Fibroblast growth factor 23: State of the field and future directions (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus)
• WNTS AND TGFB IN SYNAPTOGENESIS: OLD FRIENDS SIGNALLING AT NEW PLACES (, NA)
• Schema of the cholesterol pathway (, NA)
• Biological targets under investigation for treatment of SLE (, Homo sapiens,Mus musculus,Schizosaccharomyces pombe)
• Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud (, NA)
• BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II (, Matthiola incana,Usnea florida,Homo sapiens,Mus musculus,Danio rerio)
• Hypothesized model for actions of the cAMP-Epac-Rap1 signaling pathway at neuronal gap junctions (, NA)
• Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Vasconcellea candicans)
• Proposed model of Cripto-1 modulation of the Wnt/Beta-catenin signaling pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Xenopus laevis,vectors)
• Known relationships between the candidate genes (, NA)
• TARGETING ONCOGENIC BRAF IN HUMAN CANCER (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,Diaporthe sclerotioides,Antarctothoa delta,Harvey murine sarcoma virus)
• Alternative STAT-independent pathway of cytokine receptor cross-talk (, Drosophila melanogaster,Anopheles gambiae,Dipnomorpha,Strongylocentrotus purpuratus,Gnathostomata,Petromyzon marinus,Cyclostomata,Microcotyle sebastis,Escherichia coli,Listeria monocytogenes,Human papillomavirus,Lyssavirus rabies,Bacillus thuringiensis,Vaccinia virus GLV-1h68,Homo sapiens,Pan troglodytes,Mus musculus,Sus scrofa,cellular organisms)
• Sphingosine-1-Phosphate Rapidly Increases Cortisol Biosynthesis and the Expression of Genes Involved in Cholesterol Uptake and Transport in H295R Adrenocortical Cells (, NA)
• XBP-1 in the UPR Signaling Pathway (, NA)
• The K+ channels (, NA)
• TGFB in Cancer (, NA)
• TGFB in Cancer (, NA)
• Progastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem Cells (, Mus musculus,Rattus norvegicus,Bos taurus,Canis lupus familiaris,Homo sapiens,Curcuma longa,Citrobacter rodentium)
• Bioactive probe of the oxidative pentose phosphate cycle: novel strategy to reverse radioresistance in glucose deprived human colon cancer cells (, Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Dipturus trachyderma)
• BRCA and RAD52 pathways of DNA double-strand break (DSB) repair (, Saccharomyces cerevisiae,Arabidopsis thaliana,Zea mays,Ustilago maydis,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Escherichia coli,Gallus gallus)
• Proposed mechanisms leading to VEGF signaling pathway inhibitor-induced hypertension (, Mus musculus,Rattus norvegicus,Nicotiana tabacum,Diaporthe sclerotioides,Homo sapiens,Sus scrofa,Salminus brasiliensis)
• The expression and role of cyclic nucleotide signalling pathway in control of electrical activity in pituitary cells (, NA)
• 12-LIPOXYGENASE AND THE REGULATION OF HYPOXIA-INDUCIBLE FACTOR IN PROSTATE CANCER CELLS (, NA)
• Using components of the Vitamin D pathway to prevent/treat colon cancer (, NA)
• Summary of the mechanisms of DC-mediated HIV-1 transmission to CD4+ T cells (, NA)
• Roles of RKIP in intracellular signaling (, NA)
• Autophagy, Myocardial Protection and the Metabolic Syndrome (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Ginkgo biloba)
• Putative Altered Signaling Events occurring upon treatment of GSI (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Oryctolagus cuniculus,Capra hircus,Prorocentrum donghaiense,Homo sapiens,Drosophila melanogaster)
• Targets of the tumor suppressor gene miR-200 in regulation of the epithelial-mesenchymal transition in cancer (, NA)
• Targeting the TGFB signalling pathway in disease (, NA)
• Targeting the TGFB signalling pathway in disease (, NA)
• Molecular mechanisms of activation, amplification, regulation, and evasion of the AP C3 convertase (, NA)
• Metabolic Pathway for the Formation of CHB (1) and CBO (2) from BD, and the Subsequent Reactions of CBO with GSH to Form Three CBO-GSH Conjugates (3, 4, and 5) (, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus)
• DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis (, NA)
• Proposed role of ER calcium underlying early disruptions in synaptic homeostasis at the CA3–CA1 synapse in AD (, Mus musculus,Rattus norvegicus,Cavia porcellus,Drosophila melanogaster,Oryctolagus cuniculus,Capra hircus,Neopetrosia exigua,Homo sapiens,Diaporthe sclerotioides)
• Platinum drug action pathway (, NA)
• DNA Damage Signaling Assessed in Individual Cells in Relation to the Cell Cycle Phase and Induction of Apoptosis (, NA)
• Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches (, NA)
• Roles for the Ubiquitin-Proteasome Pathway in Protein Quality Control and Signaling in the Retina: Implications in the Pathogenesis of Age-Related Macular Degeneration (, NA)
• Proposed pathway of SubAB-induced apoptosis (, Escherichia coli,Bacillus anthracis,Escherichia coli O113H21,Escherichia coli 98NK2,Homo sapiens,Mus musculus,Bos taurus,Armoracia rusticana)
• Molecular mechanisms underlying PA and histologically anaplastic PA (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Bikinia letestui)
• Simplified diagram depicting Ras signaling and crosstalk with PI3 kinase- Akt pathway in leukemia (, Homo sapiens,Ligustrum vulgare)
• Schematic structures of NAD(H) and NADP(H) (, NA)
• Regulatory RNAs in Brain Function and Disorders (, NA)
• Insulin signaling transduction (, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Armoracia rusticana,Zea mays,Homo sapiens)
• Memory Enhancement (, NA)
• Illustration of GnRH signaling pathways necessary for FSHB induction (, NA)
• Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response (, Bos taurus,Oryctolagus cuniculus,Equus caballus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• MAPK signaling pathway and B-Raf derangements in gliomas (, NA)
• Extracellular and Intracellular Esterase Processing of SCFA-Hexosamine Analogs: Implications for Metabolic Glycongineering and Drug Delivery (, Sar,Traverhyphes indicator,Homo sapiens,Mus musculus,Escherichia coli)
• Signaling pathway (, NA)
• Novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer (, NA)
• Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity (, NA)
• Schematic displays hypothesized pre- and post-synaptic signaling pathways activated by IL-1B to induce synapse loss (, Mus musculus,Rattus norvegicus,Bos taurus,Human immunodeficiency virus 1,Equus caballus,Human immunodeficiency virus,Homo sapiens)
• Proposed pathway of urinary carnitine loss by cisplatin in wildtype mice (A) but not in Oct1/2(−/−) mice (B) (, NA)
• IFNA and LPS up-regulate APOBEC3 (A3) mRNA through different signaling pathways (, NA)
• Identification of multiple disrupted components in a biological pathway (, NA)
• p62-interacting partners and functions (, NA)
• Impact of IL-27 on lymphocyte signaling pathways (, NA)
• Receptors for IL4 and IL13 are comprised of four different subunits, IL4RA (green), gamma chain (Gc; purple), IL13RA1 (red), and IL13RA2 (yellow) (, NA)
• GSK3 signaling in neural development (, NA)
• Vorinostat, an HDAC Inhibitor Attenuates Epidermoid Squamous Cell Carcinoma Growth by Dampening mTOR Signaling Pathway in a Human Xenograft Murine Model (, NA)
• Pathways for dNTP biosynthesis in E (, Escherichia coli,Escherichia coli K-12,Escherichia coli IS1,Escherichia coli IS5,Tequatrovirus T4,Muvirus mu,Homo sapiens,Saccharomyces cerevisiae)
• Ingenuity pathway analysis reveals the close relationship between 14 of 17 of most relevant genes in rectal cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Schematic model showing the existence of distinct secretory pathways in pheochromocytoma (, Bos taurus,Canis lupus familiaris,Sus scrofa,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,bacterium NOTE,NA)
• Targeting 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) for colorectal cancer prevention and treatment (, NA)
• GSK-3 serine/threonine kinase promotes MLL-FP-mediated leukemogenesis by increasing the recruitment of HOXA9 and its cofactor MEIS1 to target genes (, Homo sapiens,Mus musculus,Xenopus laevis)
• Unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses (, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Human papillomavirus type 16,Vesicular stomatitis virus,West Nile virus,H5N1 subtype,Enterovirus C,Coxsackievirus,Human papillomavirus types,Hepatovirus A,dsRNA viruses,Aurantiochytrium single-stranded RNA virus 01,Escherichia coli,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Klebsiella pneumoniae,Porphyromonas gingivalis,Campylobacter jejuni,Escherichia coli O157H7,Yersinia enterocolitica,Finegoldia magna,Escherichia coli O55H7,Homo sapiens,Mus musculus,Bacteriophage sp.,NA,NA)
• Death receptor pathway (, NA)
• Integration of intercellular signaling through the Hippo pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Legionella secreted effectors and innate immune responses (, Salmonella enterica subsp. enterica serovar Typhimurium,Legionella pneumophila,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• PI3K-AKT-mTOR signaling pathway (, NA)
• Proposed signaling pathways of H2S in cardioprotection: representation of the putative cascade of reactions triggered by molecular H2S (, Mus musculus,Rattus norvegicus,Gallus gallus,Allium cepa,Allium sativum,Oncorhynchus mykiss,Riftia pachyptila,Arenicola marina,Homo sapiens,Bos taurus,Escherichia coli)
• PI3K Signaling in B and T Lymphocytes: New Developments and Therapeutic Advances (, NA)
• Oncogenic Transcription Factors: Cornerstones of Inflammation-Linked Pancreatic Carcinogenesis (, NA)
• Autophagy and apoptosis- what’s the connection? (, Homo sapiens,Mus musculus)
• Immunoregulatory role of anchored cAMP signaling in T cells (, Mus musculus,Rattus norvegicus,Cavia porcellus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Bos taurus)
• CYTOKINES, INFLAMMATION AND COLON CANCER (, NA)
• CYTOKINES, INFLAMMATION AND COLON CANCER (, NA)
• Autoinflammatory Disease Reloaded: A Clinical Perspective (, Homo sapiens,Mus musculus,Variola virus)
• Schematic of calcium signaling pathways in osteocytes investigated in present study (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• Complex Patterns of Altered MicroRNA Expression during the Adenoma-Adenocarcinoma Sequence for Microsatellite-Stable Colorectal Cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,Armoracia rusticana)
• MTOR signaling pathway (, NA)
• Ras signaling pathway which is disrupted in juvenile myelomonocytic leukemia (JMML) (, Homo sapiens)
• Stochastic signaling pathways regulated by oncogenic Ras in the induction of apoptosis (, NA)
• Vascular complications of diabetes: mechanisms of injury and protective factors (, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Corynephage beta,Cerobasis alpha)
• [LM5]Strategies for treatment of traumatic central nervous system (CNS) injuries (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Avian adeno-associated virus)
• G Protein-coupled Receptor FPR1 as a Pharmacologic Target in Inflammation and Human Glioblastoma (, Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Listeria monocytogenes)
• Molecular signaling alterations induced by intracellular delivery of CagA (, NA)
• Integrated scheme for MIF expression, signal transduction and regulation of glucocorticoid immunosuppression and cell survival (, Homo sapiens,Mus musculus)
• Schematic diagram showing the intracellular signaling pathway by which angiotensin type-2 receptors (AT2Rs) and dopamine -1 receptors (D1Rs) interact in the control of Na+ transport (, NA)
• Telomere syndromes (, Saccharomyces cerevisiae,Zea mays,Kluyveromyces lactis,Mus musculus,Mus musculus castaneus,Homo sapiens,Tetrahymena thermophila)
• VEGFA and BMP pathways have distinct as well as overlapping intracellular targets (, NA)
• Low-dose radiation responsive genes linked to carcinogenesis (, NA)
• Ras activation by •NO-mediated processes in pancreatic cancer (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Retinoic acid signaling pathway for neurogranin expression (, NA)
• Innate immune stimulation by LPS positively impacts T cell priming (, Homo sapiens)
• Ubiquitination in Signaling to and Activation of IKK (, NA)
• Ubiquitination in Signaling to and Activation of IKK (, NA)
• Control of cell adhesion during neuronal migration (, NA)
• KEGG pathway of the renin-angiotensin system (, NA)
• Generalized schematic representation of the BMP signaling pathway (, NA)
• The glucosinolate (GLS) pathway (, NA)
• PGN-induced miR-132 and miR-212 in TLR signaling (, NA)
• Advances in graft-versus-host disease biology and therapy (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,gut metagenome)
• Clinical Implications of Cancer Stem Cell Biology in Hepatocellular Carcinoma (, NA)
• Cocaine and Withdrawal on the Mouse Nucleus Accumbens Transcriptome (, NA)
• NleB, a bacterial effector with glycosyltransferase activity targets GADPH function to inhibit NFKB activation (, Escherichia coli,Clostridioides difficile,Citrobacter rodentium,Clostridioides difficile CD40,Mus musculus,Rattus norvegicus,Homo sapiens,Celithemis elisa)
• Chemical factors influence the cellular response to mechanical factors and vice versa (, Gallus gallus,Danio rerio,Leuciscus leuciscus,Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Cardiac myocyte signaling coupled to phosphodiesterase (PDE) 5 (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• The effect of chronic oxidative stress on the insulin signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries)
• PIAs recapitulate the activity of two tumor suppressors that converge on mTOR (, Mus musculus,Homo sapiens)
• Essential Role of PIKE GTPases in Neuronal Protection Against Excitotoxic Insults (, Mus musculus,Rattus norvegicus,Felis catus,Homo sapiens)
• DNA interstrand crosslink repair and cancer (, NA)
• DNA interstrand crosslink repair and cancer (, NA)
• The interleukin (IL)-12/IL-23/interferon (IFN)G pathway and its role in mycobacterial disease control (, NA)
• Signaling pathways involved in v-src induced initial closure of Cx43: The hypothetical model shown is based on the data presented here, and established (solid lines) or proposed connections (dashed lines) from other studies (see text) (, NA)
• Connecting the Insulin pathway to the Drosophila autophagy machinery (, NA)
• New insights for FOXO and cell-fate decision in HIV-infection (, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Ginkgo biloba,Homo sapiens,Caenorhabditis elegans,Human immunodeficiency virus 1,NA)
• TRPV4 in mechanosensitivity in the distal nephron cells (, NA)
• Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles (, Tannerella forsythia,Homo sapiens)
• Tannerella forsythia infection-induced calvarial bone and soft tissue transcriptional profiles (, Tannerella forsythia,Homo sapiens)
• TGFB signaling via TAK1 pathway: Role in kidney fibrosis (, NA)
• TGFB signaling via TAK1 pathway: Role in kidney fibrosis (, NA)
• TGFB signaling via TAK1 pathway: Role in kidney fibrosis (, NA)
• TGFB signaling via TAK1 pathway: Role in kidney fibrosis (, NA)
• MicroRNA Circuits in Transforming Growth FactorB actions and Diabetic Nephropathy (, NA)
• Cytoscape diagram of the functional interaction network representing proteins modulation in Pt1 interstitial fluid (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• Biochemical relationships between the CDP-choline pathway of PtdCho synthesis, the degradation of PtdCho, and general phospholipid metabolism in mammals (, Legionella pneumophila,Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetulus griseus,Escherichia coli,Streptococcus pneumoniae,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Glycine max,Homo sapiens,Gallus gallus,NA)
• Surfactant phospholipid metabolism (, NA)
• Oncogenic pathways in ABC-DLBCLThe stimulation of several surface receptors, including the B-cell receptor (BCR), CD40 or Toll-like receptors, triggers signaling cascades resulting in the activation of the NF-kB pathway (, Escherichia coli,Escherichia coli 53C,Homo sapiens,Mus musculus)
• Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 (, NA)
• Premetazoan origin of the Hippo signaling pathway (, NA)
• Metabolism of [U-13C]glucose in Human Brain Tumors In Vivo (, NA)
• Thyroid Hormone Receptors and Cancer (, NA)
• Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections (, Pseudomonas aeruginosa,Homo sapiens)
• EMT in fibrosis (, NA)
• Wound repair and fibrosis (, NA)
• Phosphatidic Acid Plays a Central Role in the Transcriptional Regulation of Glycerophospholipid Synthesis in Saccharomyces cerevisiae (, Saccharomyces cerevisiae,Homo sapiens)
• Proposed mechanism for opioid modulation for TLR (, Human immunodeficiency virus 1,Human immunodeficiency virus,Human betaherpesvirus 6,Mus musculus,Rattus norvegicus,Streptococcus pneumoniae,Klebsiella pneumoniae,Homo sapiens,Equus caballus,Candida albicans)
• Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression (, NA)
• Schematic presentation of the proposed involvement of signaling pathways in expression of P450s and extracellular lignin degrading enzyme system (LDS) in P (, NA)
• Role of mesothelin in cancer progressionOverexpression of mesothelin leads to higher IL-6 production by constitutively activating NFKB (, Homo sapiens,Mus musculus)
• IL-2 signals by activating three principal signaling pathways, the SHC/RAS/MAP kinase pathway, JAK1/JAK3/STAT5 pathway, and PI 3-K/AKT/p70 S6 kinase pathway (, NA)
• Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation (, Mus musculus,Xenopus laevis,murine stem cell retroviral vector,Homo sapiens)
• Understanding metabolic regulation and its influence on cell physiology (, Homo sapiens,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae)
• Genes highly expressed in TNBC compared to HR-positive, HER2-negative breast cancer (, Homo sapiens,Caenorhabditis elegans)
• Schematic diagram shows how Ca cycling proteins and other regulatory parameters affect Ca alternans via the common pathway of the 3R’s (, NA)
• SIRT1 in the brain is involved in a number of processes that affect neuronal health, neurogenesis, and behavior (, Drosophila melanogaster,Caenorhabditis elegans,Frontinella communis,Homo sapiens,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Macaca mulatta,Spondias dulcis)
• Six important signaling networks of osteoblast differentiation (, Homo sapiens,Mus musculus)
• shows the effects of osteoblast-secreted osteocalcin on glucose homeostasis and its novel role in regulating testosterone production in the leydig cells (, Homo sapiens,Mus musculus)
• Apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Armoracia rusticana)
• HIV pathogenesis and T-cell signaling by HIV-1 Nef (, Human immunodeficiency virus 1,Human immunodeficiency virus,Vesicular stomatitis virus,Human T-cell leukemia virus type I,Simian immunodeficiency virus,Homo sapiens,Macaca mulatta)
• Historical Lessons in Translational Medicine: Cyclooxygenase Inhibition and P2Y12 Antagonism (, NA)
• Microbial Cell Components Induced Tolerance to Flagellin-Stimulated Inflammation through Toll-Like Receptor Pathways in Intestinal Epithelial Cells (, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Lacticaseibacillus rhamnosus GG,Staphylococcus aureus 1-B-1,Escherichia coli O26,Homo sapiens,Mus musculus,Bos taurus)
• Development of allergic inflammation (, Mus musculus,Rattus norvegicus,Canis lupus familiaris,Felis catus,Homo sapiens,Staphylococcus aureus,Respiratory syncytial virus,Arachis hypogaea,Corynebacterium phage gamma)
• Proposed regulatory mechanism of ERB in colitis-associated colon cancer (, NA)
• Ubiquitination and Phosphorylation in the Regulation of NOD2 signaling and NOD2-mediated Disease (, NA)
• Conserved role of IGF-I in lifespan regulation and stress resistance (, NA)
• TLR-induced corneal inflammation (, Human alphaherpesvirus 1,ssRNA viruses,dsRNA viruses,Staphylococcus aureus,Pseudomonas aeruginosa,Homo sapiens,Mus musculus,Oryctolagus cuniculus,Fusarium solani,Onchocerca volvulus,NA)
• T cell receptor (TCR)-mediated signalling pathway (, NA)
• Gallium-containing anticancer compounds (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Triportheus paranensis)
• Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention (, NA)
• O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation (, NA)
• Evolution and impact of subclonal mutations in chronic lymphocytic leukemia (, Homo sapiens,Eucalyptus intertexta)
• Mitogen and stress-activated protein kinase 1 (MSK1) modulates photic entrainment of the suprachiasmatic circadian clock (, NA)
• Activity-dependent neuronal signalling and autism spectrum disorder (, Mus musculus,Rattus norvegicus,Aplysia californica,Aplysia sp.,Homo sapiens,Escherichia coli)
• Activity-dependent neuronal signalling and autism spectrum disorder (, Mus musculus,Rattus norvegicus,Aplysia californica,Aplysia sp.,Homo sapiens,Escherichia coli)
• NFKB: Roles and Regulation In Different CD4+ T cell subsets (, Homo sapiens,Mus musculus,Eutheria)
• Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy (, NA)
• Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy (, NA)
• Gene Network Analysis of Small Molecules with Autoimmune Disease Associated Genes Predicts a Novel Strategy for Drug Efficacy (, NA)
• Inflammation and Diabetes-Accelerated Atherosclerosis: Myeloid Cell Mediators (, Homo sapiens,Mus musculus,Nicotiana tabacum)
• Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets (, NA)
• Early signaling events that underlie fate decisions of naive CD4+ T cells towards distinct T-helper cell subsets (, NA)
• Lineage-specific and ubiquitous biological roles of the mammalian transcription factor LSF (, NA)
• What Goes On Must Come Off: phosphatases gate-crash the DNA damage response (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Corynebacterium phage gamma,NA)
• Synergy of chemotherapy and radiotherapy with mesenchymal stem cell (MSC)-delivered anticancer agents (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,murine stem cell retroviral vector)
• Mesenchymal stem cells (MSCs) may have both growth inhibitory and stimulatory effects on tumours (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,murine stem cell retroviral vector)
• Alliance for Cellular Signaling Plasmid Collection (, NA)
• Mechanisms involved in hypoxia-induced systemic hypertension (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Homo sapiens,Vasconcellea candicans)
• Animal models of skin disease for drug discovery (, NA)
• Transcriptional integration of mitochondrial biogenesis (, NA)
• Summary of radiation-induced long-term alterations, local and systemic, in relation to mammary glands (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Working model for the role of TAK1 lysine-72 in the negative regulation of TNFAlpha-induced NFKB activation (, Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,Armoracia rusticana,vectors)
• Oxidative pathway of ethanol metabolism (, NA)
• Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function (, NA)
• State-of-the-science: An update on renal cell carcinoma (, NA)
• Use of Metabolomic Profiling in the Study of Arachidonic Acid Metabolism in Cardiovascular Disease (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Canis lupus familiaris,Calloplesiops altivelis)
• Recent advances in prostate development and links to prostatic diseases (, Canis lupus familiaris,Metatheria,Trichosurus vulpecula,Mus musculus,Rattus norvegicus,Homo sapiens)
• Recent advances in prostate development and links to prostatic diseases (, Canis lupus familiaris,Metatheria,Trichosurus vulpecula,Mus musculus,Rattus norvegicus,Homo sapiens)
• Quercetin Increases CFTR Mediated Chloride Transport and Ciliary Beat Frequency: Therapeutic Implications for Chronic Rhinosinusitis (, NA)
• Pattern-recognition receptors (PRRs) and signaling pathways that lead to differentiation of antifungal T helper (Th) cells (, Homo sapiens)
• Schematic summarizing the effects of MIF on the canonical MAPK pathways (, NA)
• Lipid (fatty acid) metabolic pathway diagram from KEGG Pathway analysis (, NA)
• Interactions between cytokine and glucocorticoid receptor (GR) signaling pathways (, Homo sapiens,Mus musculus,Rattus norvegicus,Diaporthe sclerotioides,Macaca mulatta,Coccoloba uvifera)
• PAK1 Molecular Pathway (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Mus musculus,Danio rerio)
• Epithelial to Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma (, Homo sapiens,Human papillomavirus)
• LEM2 is a negative regulator of ERK signaling during muscle differentiation (, NA)
• Cellular and molecular mechanisms of metformin: an overview (, Mus musculus,Homo sapiens)
• Cardioprotection is typically initiated by activation of G-protein coupled receptors, which result in activation of the PI3K signaling pathway (, NA)
• Lipids in The Control of Autophagy (, Saccharomyces cerevisiae,Komagataella pastoris,Ogataea angusta,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,Salmonella enterica subsp. enterica serovar Typhimurium)
• Simplified schematic of signaling pathways driving resistance to BRAF inhibitors (, NA)
• Regulation of LTP induction in the hippocampus by NRG1-ErbB4 signaling through suppressing Src enhancement of NMDARs (, NA)
• Systems analysis of salivary gland development and disease (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens)
• Key branches of the insulin signaling cascade (, NA)
• Possible models of oncogenicity (, Homo sapiens,Mus musculus,Gallus gallus)
• Figure 2 A illustrated the interaction of the genomic and acute estrogen signaling pathways in regulating nitric oxide (NO) signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Proposed scheme for the inhibition of both arms of the mTOR pathway by p-XSC and rapamycin in C4-2 cells (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Pathways regulating intestinal sterol absorption and homeostasis (, NA)
• ATR barrier to replication-born DNA damage (, NA)
• Four simplified signaling pathways (, NA)
• Pro-osteoblastogenic signal transduction by insulin and IGF1 receptors (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cross-talk between insulin/IGF-1, BMP2, and Wnt signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens)
• PAFAH1B1 (platelet-activating factor acetylhydrolase 1 regulatory subnuit 1, formerly known as LIS1)-binding partners (, NA)
• CDK5 phosphorylation substrates during neuronal migration (, NA)
• Insulin receptors in endothelial cells co-localize with cavaolae, and insulin signaling in endothelial cells leads to two downstream signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Role of Insulin Resistance in Endothelial Dysfunction (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Endothelial dysfunction and endothelial insulin resistance co-exist in the state of insulin resistance including metabolic syndrome, obesity and diabetes (, Homo sapiens,Rattus norvegicus,Bos taurus)
• Signaling pathway by which Beta-catenin may regulate intricate inflammatory responses in liver IRI (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Oryctolagus cuniculus,Capra hircus,Siproeta stelenes,Homo sapiens)
• TLR3 immunity to infection in mice and humans (, NA)
• Regulation of NFKB by Ubiquitination (, Homo sapiens,Mus musculus,Rattus norvegicus,Escherichia coli,Shigella flexneri,Aotus trivirgatus,Saccharomyces cerevisiae,Human T-cell leukemia virus type I)
• Anaplasma phagocytophilum: deceptively simple or simply deceptive? (, NA)
• Regulation of NFKB by Ubiquitination (, Homo sapiens,Mus musculus,Rattus norvegicus,Escherichia coli,Shigella flexneri,Aotus trivirgatus,Saccharomyces cerevisiae,Human T-cell leukemia virus type I)
• Signaling mechanisms of the five major endothelium-derived hyperpolarizing factors (EDHFs) (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Glires,Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Serotonergic transcriptional networks and potential importance to mental health (, NA)
• Caspase-8 and FLIP regulate RIG-I/MDA5-induced innate immune host responses to picornaviruses (, Coxsackievirus,Dengue virus,Human gammaherpesvirus 8,West Nile virus,Enterovirus C,Measles morbillivirus,Coxsackievirus B3,Enterovirus A71,Encephalomyocarditis virus,Murine hepatitis virus,Foot-and-mouth disease virus,Human rhinovirus sp.,Hepatovirus A,Echovirus,Poliovirus 2,Human rhinovirus 1A,Coxsackievirus B2,Echovirus E7,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Equus asinus,Homo sapiens,prion,Pannonibacter phragmitetus,NA)
• Canonical or Wnt/Beta-catenin–TCF/LEF signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Interaction of pathogen recognition and ST2 receptor systems with FcERI leads to substantial enhancement of production of cytokines and chemokines (, NA)
• Estrogen synthesis and signaling pathways during ageing: from periphery to brain (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Papio anubis,Equus caballus,Olea europaea,Coturnix coturnix)
• Estrogen synthesis and signaling pathways during ageing: from periphery to brain (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Papio anubis,Equus caballus,Olea europaea,Coturnix coturnix)
• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Possible pathways leading to inhibition of extracellular signal regulated kinase (ERK)1/2 phosphorylation by A2B adenosine receptors (A2BARs) (, NA)
• Kaempferol’s Effects on the MAPK Pathway (, NA)
• Hepatocyte growth factor sensitizes brain tumors to c-MET kinase inhibition (, Homo sapiens,Mus musculus,Bikinia letestui)
• Insulin/IGF-1 signaling pathway in vector arthropods (, Drosophila melanogaster,Caenorhabditis elegans,Plasmodium falciparum,Trypanosoma cruzi,Aedes aegypti,Trypanosoma brucei,Leishmania major,Anopheles gambiae,Plasmodium berghei,Aedes albopictus,Plasmodium vivax,Ixodes scapularis,Culex quinquefasciatus,Rhodnius prolixus,Glossina morsitans,Plasmodium yoelii,Anopheles stephensi,Trypanosoma brucei brucei,Culex pipiens,Trypanosoma brucei gambiense,Rhipicephalus microplus,Amblyomma americanum,Pediculus humanus,Dermacentor variabilis,Theileria annulata,Pediculus humanus corporis,Ornithodoros moubata,Rhipicephalus sanguineus,Anopheles aquasalis,Haemaphysalis longicornis,Triatoma dimidiata,Phlebotomus papatasi,Triatoma infestans,Culex tritaeniorhynchus,Babesia bigemina,Lutzomyia spinicrassa,Homo sapiens,Macaca mulatta,Borreliella burgdorferi,Papio anubis,Anaplasma phagocytophilum,Anaplasma marginale,Mus musculus,Rattus norvegicus,Dengue virus,Vaccinia virus,Saccharomyces cerevisiae,Bos taurus)
• TGFB1 signaling pathway in vector arthropods (, Drosophila melanogaster,Caenorhabditis elegans,Plasmodium falciparum,Trypanosoma cruzi,Aedes aegypti,Trypanosoma brucei,Leishmania major,Anopheles gambiae,Plasmodium berghei,Aedes albopictus,Plasmodium vivax,Ixodes scapularis,Culex quinquefasciatus,Rhodnius prolixus,Glossina morsitans,Plasmodium yoelii,Anopheles stephensi,Trypanosoma brucei brucei,Culex pipiens,Trypanosoma brucei gambiense,Rhipicephalus microplus,Amblyomma americanum,Pediculus humanus,Dermacentor variabilis,Theileria annulata,Pediculus humanus corporis,Ornithodoros moubata,Rhipicephalus sanguineus,Anopheles aquasalis,Haemaphysalis longicornis,Triatoma dimidiata,Phlebotomus papatasi,Triatoma infestans,Culex tritaeniorhynchus,Babesia bigemina,Lutzomyia spinicrassa,Homo sapiens,Macaca mulatta,Borreliella burgdorferi,Papio anubis,Anaplasma phagocytophilum,Anaplasma marginale,Mus musculus,Rattus norvegicus,Dengue virus,Vaccinia virus,Saccharomyces cerevisiae,Bos taurus)
• T cell signaling pathways and protein phosphorylation sites identified to be differential between NOD and B6g7 mice in stimulated cells (, NA)
• Inhibition of Na+-K+-2Cl− cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells (, NA)
• SLC41 family of MgtE-like magnesium transporters (, NA)
• PI3K/Akt/mTOR signaling in breast cancer (, NA)
• Altered expression of cytokine signaling pathway genes in peripheral blood cells of alcohol dependent subjects: Preliminary findings (, NA)
• Adenosine Signaling During Acute and Chronic Disease States (, NA)
• TGFB/BMP and the Wnt pathway (, NA)
• simplified and unified view of the multi-level cross-talk (, NA)
• EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance (, NA)
• Wnt/Beta-catenin signaling in T cell immunity and cancer immunotherapy (, NA)
• Recognition of nucleic acids by innate immune cells triggers cytokine production (, NA)
• Cancer cells undergo metabolic re-programming (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Interleukin-1 alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil (, NA)
• Insulin signaling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Bikinia letestui)
• Metabolic regulation of epigenetics (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Association between mTOR and the PI-3K–Akt intracellular signaling pathway in vascular endothelial cells (, NA)
• Routes of AMPAR trafficking (, Homo sapiens,Mus musculus)
• Epidermis model pathways (, Drechmeria coniospora,Homo sapiens)
• Wnt signaling pathways (, NA)
• Unfolded protein response and its role in intestinal homeostasis and inflammation (, Escherichia coli,Pseudomonas aeruginosa,Salmonella sp.,Streptomyces sp. sp1,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (, NA)
• Seven important signaling networks of osteoblast differentiation (, NA)
• Transcription factors and signaling involved in the osteoblast differentiation pathway (, NA)
• Subnetworks identified from TCGA ovarian cancer gene expression data set (, Homo sapiens,Venustaconcha ellipsiformis)
• Enriched pathways and GO functional annotations are: (a) ErbB signaling pathway: p=9.10e-13; Signal transduction p=2.33e-07 (, Homo sapiens,Venustaconcha ellipsiformis)
• Enriched pathways and GO functional annotations are: (a) NFKB signaling pathway p=7.03e-05 (, Homo sapiens,Venustaconcha ellipsiformis)
• Signaling Circuitries Controlling Stem Cell Fate: To Be or Not To Be (, NA)
• Proteome coverage of the KEGG ‘Insulin Signaling’ pathway (, NA)
• Proposed synergistic pathway to mitotic cell death in cells treated with a combination of paclitaxel and gefitinib or the PLK1 inhibitor BI2536 (, NA)
• Role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development (, Gallus gallus,Danio rerio,Homo sapiens,Mus musculus)
• Harmonies Played by TGFB in Stem Cell Biology (, NA)
• Association of Luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies (, NA)
• Regulation of Akt Activation by the PI 3-K pathway (, NA)
• IGF-1R and EGFR/HER2crosstalk occurs by two main mechanisms (, NA)
• Calciomics: integrative studies of Ca2+-binding proteins and their interactomes in biological systems (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Escherichia coli,Caenorhabditis elegans,Rubella virus)
• Phosphoinositide 3-Kinase Inhibition in Chronic Lymphocytic Leukemia (, NA)
• Neuroprotective signaling pathways employed by Erythropoietin (, NA)
• Caspases and Kinases in a Death Grip (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Citrus medica,Homo sapiens,Mus musculus,Drosophila melanogaster,Canis lupus familiaris,Xenopus laevis)
• Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability (, Mus musculus,Saccharomyces cerevisiae,Gallus gallus,Nicotiana tabacum,Xenopus laevis,Cricetus cricetus,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability (, Mus musculus,Saccharomyces cerevisiae,Gallus gallus,Nicotiana tabacum,Xenopus laevis,Cricetus cricetus,Homo sapiens,Escherichia coli,Drosophila melanogaster)
• Signalling regulation of mammalian autophagy (, Drosophila melanogaster,Caenorhabditis elegans,Toxoplasma gondii,Dictyostelium discoideum,Manduca sexta,Sarcophaga bullata,Chironomus tentans,Mycobacterium tuberculosis,Listeria monocytogenes,Salmonella enterica,Streptococcus pyogenes,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Ogataea angusta,Homo sapiens)
• mTOR: from growth signal integration to cancer, diabetes and ageing (, Drosophila melanogaster,Caenorhabditis elegans,Dictyostelium discoideum,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• An emerging role of mTOR in lipid biosynthesis (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Emerging roles of E2Fs in cancer: an exit from cell cycle control (, Saccharomyces cerevisiae,Drosophila melanogaster,Arabidopsis thaliana,Caenorhabditis elegans,Homo sapiens,Mus musculus,clinical samples,Betapolyomavirus macacae)
• Personalized Medicine and Inhibition of EGFR Signaling in Lung Cancer (, NA)
• The multi-step pathway of CENP-A-containing centromeric chromatin replication utilizing sequential, temporally separated steps across the mammalian cell cycle (, Saccharomyces cerevisiae,Arabidopsis thaliana,Candida albicans,Schizosaccharomyces pombe,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Homo sapiens)
• TGFB restoration by SMAD6 knockdown (, NA)
• Emerging actions of the nuclear receptor LRH-1 in the gut (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Equus caballus,Hepatitis B virus,NA)
• Ras/Raf/MEK/ERK pathway.Binding of growth factors (GF) to receptor tyrosine kinases (RTK) leads to recruitment of adaptor proteins and guanine exchange factors (GEF) (, NA)
• Simplified version of the insulin signaling pathway (, NA)
• Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target (, NA)
• PI3K Enters Beta-Testing (, Homo sapiens,Mus musculus,Gallus gallus)
• Transcriptome analysis of HeLa cells response to Brucella melitensis infection: A molecular approach to understand the role of the mucosal epithelium in the onset of the Brucella pathogenesis (, Brucella melitensis,Homo sapiens)
• Membrane-initiated Actions of Estradiol that Regulate Reproduction, Energy Balance and Body Temperature (, NA)
• Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway In Cancer Prevention and Treatment (, NA)
• Interleukin-1B enhances cell migration through AP-1 and NFKB pathway dependent FGF2 expression in human corneal endothelial cells (, NA)
• Resection of Non-Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System (, NA)
• Significantly changing expression sub-networks in LMB hypothalamus (, Oncorhynchus mykiss,teleost fish,Carassius auratus,Dipnomorpha,Salmo trutta,catfish,Micropterus salmoides,Pimephales promelas,Cyprinus carpio color,Clarias gariepinus,Acanthopagrus schlegelii,Sphyrna tiburo,Mus musculus,Rattus norvegicus,Bos taurus,Capra hircus,Homo sapiens,Drosophila melanogaster,Diaporthe sclerotioides)
• Proposed model for PDGF-D signaling pathway that controls the processes of EMT (, Homo sapiens,Mus musculus,Symphonia globulifera)
• Modeling spatially restricted biochemical reactions (, NA)
• Feed-forward relay for decoding signal duration (, NA)
• ROS-dependent signaling pathway activated by s-flow, which induces eNOS-mediated NO production and subsequently increases mitochondria-derived H2O2 (, NA)
• Ischemia-reperfusion injury in the diabetic myocardium is multi-factorial and complex (, NA)
• Interactions between the growth factor and Beta-adrenergic receptor pathways (, NA)
• Modeling Cell Signaling Networks (, NA)
• Cardiovascular Complications Associated with Novel Angiogenesis Inhibitors: Emerging Evidence and Evolving Perspectives (, NA)
• Regulation of miRNA biogenesis and turnover in the immune system (, NA)
• Control of Alternative Splicing in Immune Responses: Many Regulators, Many Predictions, Much Still to Learn (, Human immunodeficiency virus 1,Human immunodeficiency virus,Human T-cell leukemia virus type I,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Trichogramma alpha)
• Achieving cancer cell death with PI3K/mTOR-targeted therapies (, NA)
• Targets for inhibition within the EGFR signaling pathway (, NA)
• MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches (, NA)
• MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches (, NA)
• MUC1-C Oncoprotein as a Target in Breast Cancer; Activation of Signaling Pathways and Therapeutic Approaches (, NA)
• Wnt3a/Beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signaling program (, NA)
• Simplified scheme of the complement activation network (, Escherichia coli,Porphyromonas gingivalis,Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• The control of ERA expression and cardioprotection by MEF2 and class II HDACs (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Griffonia simplicifolia)
• Aging signaling pathways and circadian clock-dependent metabolic derangements (, NA)
• Candida albicans morphogenesis and host defence: discriminating invasion from colonization (, NA)
• Diversity in endothelium- dependent dilator pathways in the human microcirculation (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Cavia porcellus,Mesocricetus auratus,Homo sapiens)
• The signalling transduction pathways involving the tuberous sclerosis proteins, hamartin and tuberin (, Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma,Spodoptera frugiperda)
• Overview on the mechanisms of glutathione induced cell death (, Mus musculus,Rattus norvegicus,Dipturus trachyderma,Calloplesiops altivelis,Homo sapiens,Bos taurus)
• Regulation of angiogenesis by microRNAs (miRNAs) (, NA)
• Activation of NKT cells (, NA)
• Genes and signaling pathways involved in ureteric budding (, NA)
• FOXO proteins are involved in multiple signaling pathways that control cell proliferation, apoptosis, survival, and immune functions in response to external and internal stimuli (, Homo sapiens)
• Genes and signaling pathways involved in ureter development (, NA)
• NAMPT in mammalian NAD metabolism (, Escherichia coli,Salmonella enterica,Microbacterium aurantiacum,Homo sapiens,Saccharomyces cerevisiae)
• Ingenuity Pathway Analysis (IPA) was performed with proteins where SUMO3 conjugation was 2- or more fold up-regulated in any gel slice (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Armoracia rusticana)
• Androgens up-regulating PCa cell proliferation via p66Shc-ROS signal pathway (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Central roles for BDNF in the beneficial effects of exercise, dietary energy restriction and cognitive challenges on brain health (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Human immunodeficiency virus 1,Dracocephalum tanguticum)
• GW182 controls Drosophila circadian behavior and PDF-Receptor signaling (, NA)
• Thioredoxin-Interacting Protein Mediates Sustained VEGFR2 Signaling in Endothelial Cells required for Angiogenesis (, NA)
• Leptin and adiponectin activate signaling components that integrate PI3K/Akt, RAS/MAPK, and pAMPK/mTor pathways (, NA)
• Mi-2/NuRD complex making inroads into DNA-damage response pathway (, Mus musculus,Rattus norvegicus,Xenopus laevis,Calloplesiops altivelis,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Kappa opioid receptors regulate stress-induced cocaine-seeking and synaptic plasticity (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Schematic overview of estradiol-mediated genomic signaling pathway via ERA/B and rapid nongenomic signaling pathways via GPER, Gq-mER, and membrane subpopulation mERA/B (, NA)
• RAS oncogenes: weaving a tumorigenic web (, NA)
• RAS oncogene signaling (, NA)
• Schematic model of the Hippo signaling cascade in mammals (, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• BTB restructuring is mediated in part by serine/threonine kinases belonging to the MAPK pathway, which transduces signals received from external stimuli (e.g., cytokines and environmental toxicants) (, NA)
• HCMV management of the PI3K/AKT/mTOR pathway (, NA)
• GLI1 Isoforms and cancer characteristics (, NA)
• Regulation of GLI1 the isoforms by the canonical and noncanonical pathways (, NA)
• Interplay between viruses and host mRNA degradation (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,unidentified influenza virus,Dengue virus,Human betaherpesvirus 5,Human gammaherpesvirus 8,Vaccinia virus,Human T-cell leukemia virus type I,West Nile virus,Enterovirus C,Moloney murine leukemia virus,Sindbis virus,Reovirus sp.,Coxsackievirus,Murine hepatitis virus,Lyssavirus rabies,Yellow fever virus,Dengue virus type 2,Semliki Forest virus,SARS coronavirus NS-1,Murine coronavirus,Rous sarcoma virus,Murid gammaherpesvirus 4,Murid herpesvirus 68,Cowpox virus,Kunjin virus,Brome mosaic virus,Poliovirus 3,Western equine encephalitis virus,Saccharomyces cerevisiae virus L-A,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA,NA,NA,NA,NA,NA)
• Network 1 (antigen presentation, cell-mediated immune response, and humoral immune response) generated by pathway analysis of the hot list (, NA)
• SnoN Signaling in Proliferating Cells and Postmitotic Neurons (, NA)
• LPS/ KLA stimulated eicosanoid metabolism and signaling pathway (, Saccharomyces cerevisiae,Arabidopsis thaliana,Oryza sativa,Homo sapiens,Escherichia coli,Escherichia coli IS1,Mandrillus leucophaeus,Mus musculus,unidentified)
• Network 2 (metabolic disease, renal and urologic disease, and molecular transport) generated by pathway analysis of the hot list (, NA)
• Cytokine signaling cascades that influence tropoelastin transcription (, NA)
• PMEL: A PIGMENT CELL-SPECIFIC MODEL FOR FUNCTIONAL AMYLOID FORMATION (, NA)
• Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small cell lung cancer (, Homo sapiens,Mus musculus)
• Stress response pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Nutrient Signaling to mTOR and Cell Growth (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Streptomyces hygroscopicus)
• Nutrient Signaling to mTOR and Cell Growth (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Streptomyces hygroscopicus)
• Nutrient Signaling to mTOR and Cell Growth (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Streptomyces hygroscopicus)
• Shh signalling pathway1 (, Gallus gallus,Lareunionomyces loeiensis,Molva molva,Solanum aethiopicum,Homo sapiens,Mus musculus,Drosophila melanogaster,Paraechinus aethiopicus)
• Signaling Pathways in Schizophrenia: emerging targets and therapeutic strategies (, NA)
• Signaling Pathways in Schizophrenia: emerging targets and therapeutic strategies (, NA)
• Signaling pathways and their targeted therapies in NSCLC (, NA)
• Alternative Macrophage Activation and Metabolism (, Homo sapiens,Mus musculus,Drosophila melanogaster)
• Identification of genes in the camp-mediated signaling pathway whose expression was altered in association with recovery (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens)
• Signaling Networks of the Herpesvirus Entry Mediator (TNFRSF14) in Immune Regulation (, Influenza A virus,Human alphaherpesvirus 1,Human betaherpesvirus 5,Human alphaherpesvirus 2,Staphylococcus aureus,Listeria monocytogenes,Homo sapiens,Mus musculus,Plasmodium berghei ANKA,NA)
• FOXM1’s role in thyroid cancer (, NA)
• Transforming growth factorB (TGFB) signaling pathway (, NA)
• Pluripotent Stem Cells: Immune to the Immune system? (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,NA)
• MTOR signaling pathway (, NA)
• Purine nucleotide synthesis and its role in regulation of AMPK (, NA)
• TRAIL-activated proapoptotic and antiapoptotic pathways (, NA)
• Two major pathways to apoptosis (, NA)
• Proposed mechanisms that link synaptic activity, cerebral vasculature regulation and astrocytic energy metabolism with astrocytic Ca2+signaling (, Mus musculus,Rattus norvegicus,Homo sapiens)
• IL-33 signalling pathways (, Homo sapiens,Mus musculus,Human gammaherpesvirus 8,Cryptomeria japonica)
• Eicosanoid biosynthesis and EP receptor signaling pathway (, NA)
• Oncogenic signaling pathways regulated by NO and PP2A (, Betapolyomavirus macacae,Polyomavirus sp.,Homo sapiens,Rattus norvegicus,Plasmodium falciparum,Citrobacter rodentium)
• Cross-regulation between the IL-1B/IL-18 processing inflammasome and other inflammatory cytokines (, NA)
• Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches (, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches (, Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1)
• Frizzled receptors signal through G proteins (, NA)
• On/off switches of the mitochondrial uncoupling proteins (, NA)
• Steroid Receptor Coactivator-3 as a Potential Molecular Target for Cancer Therapy (, NA)
• Humanin: a harbinger of mitochondrial-derived peptides? (, NA)
• Mechanisms that Regulate Stem Cell Aging and Life Span (, Homo sapiens,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Saccharomyces cerevisiae,Thymallus thymallus,NA)
• The complement system (, NA)
• Nitric oxide signaling pathway (, NA)
• Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes (, NA)
• Direct targeting of MEK1/2 and RSK2 by silybin induces cell cycle arrest and inhibits melanoma cell growth (, Mus musculus,Capra hircus,Anemia multiplex,Homo sapiens)
• Implications of Protein Post-translational Modifications in IBD (, Escherichia coli,Bacteroides thetaiotaomicron,Homo sapiens,Mus musculus,Caenorhabditis elegans,Lareunionomyces loeiensis)
• Induction and maintenance of IDO in dendritic cells (, Human alphaherpesvirus 1,unidentified influenza virus,Homo sapiens,Mus musculus,Candida albicans)
• Proposed scheme linking metabolic and signaling pathways to insulin resistance in the heart (, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis)
• HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer (, Homo sapiens,Mus musculus)
• Genetic-based biomarkers and next-generation sequencing: the future of personalized care in colorectal cancer (, Homo sapiens,Escherichia coli,Nicotiana tabacum)
• Genetic-based biomarkers and next-generation sequencing: the future of personalized care in colorectal cancer (, Homo sapiens,Escherichia coli,Nicotiana tabacum)
• Cardiac Lipotoxicity: Molecular Pathways and Therapeutic Implications (, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,Corynephage beta,Cerobasis alpha)
• Androgen regulation of epithelial–mesenchymal transition in prostate tumorigenesis (, NA)
• Iron and Diabetes Risk (, NA)
• Roles of DNA Helicases in the Mediation and Regulation of Homologous Recombination (, NA)
• Interplay Between the Cancer Genome and Epigenome (, Homo sapiens,Mus musculus,NA)
• Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum,Streptococcus pneumoniae,Triportheus paranensis)
• mTOR signaling and its regulation by DGKs (, NA)
• Function network built upon genes selected from the identified genetic component (, NA)
• Therapeutic targeting of the p53 pathway in cancer stem cells (, NA)
• MEK inhibition increases lapatinib sensitivity via modulation of FOXM1 (, NA)
• Network was generated using Ingenuity Pathway Analysis (Ingenuity Systems, www.ingenuity.com) (, NA)
• miR-23a, a critical regulator of “migR”ation and metastasis in colorectal cancer (, Homo sapiens,Mus musculus)
• Environmental regulation of GSC proliferation at developmental stages of the gonad (, NA)
• Mechanism of endorepellin dual receptor antagonism and block of angiogenesis (, NA)
• Regulation of Wnt/Beta-catenin Signaling within and from Osteocytes (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Drosophila melanogaster,Gallus gallus,Mouse mammary tumor virus)
• Lin28: Primal Regulator of Growth and Metabolism in Stem Cells (, NA)
• Insulin signalling attenuates cAMP-mediated lipolysis at multiple steps in adipocytes (, NA)
• EphA Receptor Signaling – Complexity and Emerging Themes (, NA)
• Mutations in glutamate signaling pathway and its associated proteins in melanoma (, NA)
• The mechanism of late PC (, NA)
• Activation pathway of pDCs responding to viral nucleic acids and negative regulation of the pDC function by surface receptors (, Human immunodeficiency virus 1,Hepatitis B virus,Influenza A virus,unidentified influenza virus,H1N1 subtype,H5N1 subtype,Human alphaherpesvirus 2,Murid betaherpesvirus 1,H3N2 subtype,ssRNA viruses,Influenza A virus H3N2,Homo sapiens,Macaca mulatta,Chlorocebus aethiops,Cercocebus atys,Mus musculus,Rattus norvegicus,Sus scrofa,Ovis aries,Drosophila melanogaster,NA,NA)
• Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Drosophila melanogaster,Xenopus laevis)
• Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases (, NA)
• Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases (, NA)
• Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases (, NA)
• Ras Family of Small GTPases In Immunity And Inflammation (, NA)
• Neural Regulation of Lacrimal Gland Secretory Processes: Relevance in Dry Eye Diseases (, NA)
• Marginal zone B cells: virtues of innatelike antibody-producing lymphocytes (, NA)
• Action of TIEG in the TGFBeta-Smad signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• PTPN11-Associated Mutations in the Heart: Has LEOPARD changed its RASpots? (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Panthera pardus)
• Intersection of pathways controlling Wnt/Beta-catenin signaling and cadherin-mediated adhesion (, NA)
• Central role of Beta-catenin in Wnt signaling and the cadherin complex (, NA)
• Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Signaling pathway of HGF and Met (, NA)
• Autophagy in alcohol-induced liver diseases (, NA)
• Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Danio rerio,Diaporthe sclerotioides,Osphranter robustus)
• Diagram of genes that have been implicated in susceptibility to CL and ML disease caused by L (, Leishmania major,Leishmania braziliensis,Major minor,Acanthobothrium sp. 1,Homo sapiens,Mus musculus)
• Spatial and temporal organization of ubiquitin networks (, NA)
• Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio)
• Beta-Adrenergic Receptor Signaling in Heart Failure and Longevity: Targeting Adenylyl Cyclase Type 5 (, NA)
• Beta-Adrenergic Receptor Signaling in Heart Failure and Longevity: Targeting Adenylyl Cyclase Type 5 (, NA)
• Signaling pathways involving PKR-mediated inflammation and immune regulation (, Homo sapiens,Mus musculus,Escherichia coli,Vaccinia virus)
• ENDOCRINE RESISTANCE IN BREAST CANCER (, Homo sapiens,Mus musculus)
• Hippocampal BDNF/TrkB signaling pathways that modulate depressive behavior and antidepressant responses (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Ciliary signaling pathways implicated in control of cell proliferation (, NA)
• Genetic predisposition to peripheral nerve neoplasia: Diagnostic criteria and pathogenesis of neurofibromatoses, Carney complex, and related syndromes (, NA)
• CoA biosynthesis in E (, Escherichia coli,Escherichia coli str. K-12 substr. MG1655,Lactobacillus helveticus)
• Coagulation and complement cascades (, Escherichia coli,Pseudomonas aeruginosa,Porphyromonas gingivalis,Pseudomonas aeruginosa 2C1A,Homo sapiens,Macaca fascicularis,Papio hamadryas,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus)
• Simplified scheme of the correlation between Notch signaling components and CDX2 amounts determined in the study with and without inhibition by DCA and DAPT (, Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus)
• Main interaction sites of anticancer metal complexes with cellular redox and oxidative stress pathways (, NA)
• Liver Ischemia and Reperfusion Injury: New Insights Into Mechanisms of Innate – Adaptive Immune-Mediated Tissue Inflammation (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity (, NA)
• Signaling network of HER-2-mediated NFKB activation in radio- andlor chemo-resistant breast cancer cells (, NA)
• Notch signaling in the vasculature (, NA)
• Simplified model of the opposing roles of PHB1 in tumorigenesis (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Salmonella enterica subsp. enterica serovar Typhimurium,Salmonella enterica subsp. enterica serovar Typhi,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,NA)
• Schema of the FUS1 pathway (, Homo sapiens)
• Notch signaling in the vasculature (, NA)
• Multigene Kinase Network, Kidney Transport and Salt in Essential Hypertension (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Glia-mediated detrimental and beneficial inflammatory pathways in PD (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Mouse mammary tumor virus)
• Wnt1/Fzd-1/Beta-catenin signaling as a candidate regulatory circuit controlling mesencephalic DAergic neuron–astrocyte crosstalk (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Mouse mammary tumor virus)
• Regulation of alternative splicing by signaling (, NA)
• Statins Are Associated with Reduced Risk of Esophageal Cancer, Particularly in Patients with Barrett’s Esophagus: A Systematic Review and Meta-Analysis (, Homo sapiens,Diaporthe sclerotioides,Alces americanus)
• O-GlcNAcylation in FGF signaling (, Drosophila melanogaster,Armoracia rusticana,Triticum aestivum,Matthiola incana,Trypanosoma cruzi,Trypanosoma brucei,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Danio rerio)
• NSAIDs perturbed genes related to thrombosis, fibrinolysis, and PAR signaling (, NA)
• From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited (, Mycobacterium tuberculosis,Listeria monocytogenes,Klebsiella pneumoniae,Borreliella burgdorferi,Citrobacter rodentium,Lareunionomyces loeiensis,Candida albicans,Cryptococcus neoformans var. neoformans,Candida albicans 23P,Homo sapiens,Mus musculus,Saimiriine gammaherpesvirus 2,Toxocara canis)
• Association between TLR4 and chitinase 3-like 1 (CHI3L1/YKL-40) signaling on colonic epithelial cells in inflammatory bowel disease and colitis-associated cancer (, NA)
• Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses (, NA)
• Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses (, NA)
• Novel zebrafish model reveals a critical role for mapk in lymphangiogenesis (, NA)
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (, NA)
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (, NA)
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (, NA)
• Major signaling pathways leading to cellular apoptosis (, Escherichia coli,Mycobacterium tuberculosis variant bovis BCG,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Functional chromaffin cell plasticity in response to stress: focus on nicotinic, gap junction, and voltage-gated Ca2+ channels (, NA)
• Sites of PP2A activity within the network of ERK activation (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• SHP-1 and SHP-2 are phosphatases that can play opposite roles in the regulation of signalling pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis)
• Assembly of targeting patches and inside–out orientation of the secretory pathway (, NA)
• Regulation of vascular cell signaling by thrombospondin-1 and CD47 (, Influenza A virus,Dengue virus,West Nile virus,Ebola virus,Japanese encephalitis virus,Human alphaherpesvirus 2,Porcine reproductive and respiratory syndrome virus,Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Danio rerio,Sus scrofa,NA,NA)
• Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Xenopus laevis,Corynebacterium phage gamma,Aphyosemion alpha,Bacillus phage Gamma,Homo sapiens,Saccharomyces cerevisiae,Oryctolagus cuniculus,Betapolyomavirus macacae)
• Cell cycle regulation of Golgi membrane dynamics (, Homo sapiens,Rattus norvegicus,Drosophila melanogaster)
• Current landscape for T-cell targeting in autoimmunity and transplantation (, NA)
• Endoplasmic Reticulum and the Unfolded Protein Response: Dynamics and Metabolic Integration (, NA)
• IDENTIFICATION AND DESCRIPTION OF A NOVEL MURINE MODEL FOR POLYTRAUMA AND SHOCK (, Homo sapiens,Mus musculus)
• Molecular Biology of Lung Cancer: Clinical Implications (, NA)
• Molecular Biology of Lung Cancer: Clinical Implications (, NA)
• Molecular Biology of Lung Cancer: Clinical Implications (, NA)
• Molecular Biology of Lung Cancer: Clinical Implications (, NA)
• IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis (, Homo sapiens,Mus musculus,Catopsilia pomona,NA)
• IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis (, Homo sapiens,Mus musculus,Catopsilia pomona,NA)
• Abbreviated Pluripotent Cell Cycle (, Homo sapiens,Mus musculus,Drosophila melanogaster,Melia azedarach)
• Mechanisms underlying molecularly targeted therapeutics-induced cardiac toxicity (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular Rheostat at the Interface of Cancer and Diabetes (, NA)
• Observed effects of Hedgehog and Wnt inhibition, and Sox17 overexpression in HOG cells (, Oryctolagus cuniculus,Capra hircus,Paraechinus aethiopicus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Matthiola incana,Homo sapiens,Drosophila melanogaster,Bartonella vinsonii)
• Phosphatidic Acid and Lipid Sensing by mTOR (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Danio rerio)
• Role of SHIP1 in bone biology (, Homo sapiens,Mus musculus)
• Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Heat Shock Proteins Are Important Mediators of Skeletal Muscle Insulin Sensitivity (, NA)
• TNIP1-mediated signaling pathways (, NA)
• miR221/222 in Cancer: Their Role in Tumor Progression and Response to Therapy (, Mus musculus,Rattus norvegicus,Homo sapiens)
• New Advances in the Diagnosis and Treatment of Autoimmune Lymphoproliferative Syndrome (ALPS) (, NA)
• Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition (, NA)
• New look at TCR signaling to NFKB (, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Where No Synapses Go: Gatekeepers of Circuit Remodeling and Synaptic Strength (, NA)
• Plasminogen Activator Inhibitor-1: The Double Edged Sword in Apoptosis (, NA)
• Eicosanoids in Metabolic Syndrome (, NA)
• Notch pathway (, NA)
• Hypothetic models for the role of F-CPE and ΔN-CPE in Wnt signaling (, Bos taurus,Oryctolagus cuniculus,Equus caballus,Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Armoracia rusticana,Vesicular stomatitis virus)
• Musashi signaling pathways associated with mammary progenitor cell expansion (, NA)
• Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease (, NA)
• Accessory molecules for Toll-like receptors and their function (, NA)
• Schematic showing some major pathways implicated in cancer progression using Drosophila studies (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Canonical ATR signaling pathway and functions of newly identified regulators.(A) ATR signaling is activated in response to single-stranded DNA gaps in the genome (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Xenopus laevis,Human alphaherpesvirus 1,Bacillus cereus)
• Wound Healing in Development (, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Diaporthe sclerotioides,Ovis aries)
• Alterations of the AKT pathway in human cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Citrus macrophylla,NA)
• Canonical pathway analysis (, NA)
• Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines (, Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,H5N1 subtype,H3N2 subtype,Escherichia coli,Staphylococcus aureus,Streptococcus pneumoniae,Acholeplasma laidlawii,Homo sapiens,Gallus gallus,Meleagris gallopavo,Mandrillus leucophaeus)
• Novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair (, NA)
• Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair (, Gallus gallus,Danio rerio,Xenopus laevis,Carassius auratus,Drosophila melanogaster,Caenorhabditis elegans,Aplysia californica,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces cerevisiae VR1,Homo sapiens,Oryctolagus cuniculus,Bacteriophage sp.)
• Aspirin targets multiple components of the AMPK/mTOR signaling pathway in colorectal cancer (, NA)
• P38 MAP kinase pathway (, NA)
• EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets (, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• Components and targets of pro-phenol oxidase, Toll-Dorsal/Dif and JAK/STAT pathways (, Drosophila melanogaster,Drosophila simulans,Heliothis virescens,Leptopilina boulardi,Drosophila yakuba,Drosophila sechellia,Campoletis sonorensis,Asobara tabida,Drosophila mauritiana,Drosophila santomea,Ganaspis xanthopoda,Leptopilina heterotoma,Leptopilina victoriae,Drosophila teissieri,Homo sapiens,Listeria monocytogenes,Ichnoviriform sonorense)
• EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets (, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• EGFR/TGFA and TGFB/CTGF Signaling in Neuroendocrine Neoplasia: Theoretical Therapeutic Targets (, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples)
• IRE1Alpha- and PERK-mediated cell death pathways (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Saccharomyces cerevisiae CAT-1,Homo sapiens,prion,Felis catus)
• Apoptotic pathways regulated by the UPR (, Saccharomyces cerevisiae,Armoracia rusticana,Vasconcellea candicans,Dianthus caryophyllus,Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Caenorhabditis elegans)
• SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Two CDC42 paralogs modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions (, Cryptococcus neoformans,Homo sapiens)
• Depiction of Notch pathway and loci at which current and experiemental inhibitors block (, NA)
• Exploiting conformational ensembles in modeling protein-protein interactions on the proteome scale (, NA)
• Role of the TSH receptor in the immunopathogenesis of Graves’ ophthalmopathy (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus)
• Many host factors are involved at each step of the HCV life cycle, which starts with virus binding to its specific receptors (CD81, CLDN1, OCLN, and SR-BI) (, NA)
• Recent developments on immunotherapy for brain cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides,Pseudomonas aeruginosa,Human alphaherpesvirus 1,Patella vulgata)
• Depiction of arachidonic acid signaling pathway highlighting genes measured in this study (, Homo sapiens,Mus musculus)
• Is the Amyloid Hypothesis of Alzheimer's disease therapeutically relevant? (, NA)
• Model depicting the role of Wls/Gpr177 in regulating the Wnt signaling pathway (, NA)
• CXCR2: a target for pancreatic cancer treatment? (, NA)
• Murine mutants in the study of systemic iron metabolism and its disorders: an update on recent advances (, Mus musculus,Rattus norvegicus,Subgroup C,Feline leukemia virus,Homo sapiens,Danio rerio)
• Oxidative Stress, Plasminogen Activator Inhibitor 1, and Lung Fibrosis (, NA)
• Molecular Pathways: Extracting Medical Knowledge from High Throughput Genomic Data (, Homo sapiens,Venustaconcha ellipsiformis)
• Marked alterations in the distal gut microbiome linked to diet-induced obesity (, NA)
• Different layers of the epidermis, and the functions within those layers regulated by VDR and its coactivators (, NA)
• Canonical wnt signaling pathway (, NA)
• MODELS OF INSULIN RESISTANCE AND HEART FAILURE (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Homo sapiens,Candida dubliniensis)
• Schematic model of FGF-2 and FGF-18 signaling pathways in articular cartilage and IVD (, NA)
• Wnt signaling pathways (, NA)
• Metabolic crossroads of iron and copper (, NA)
• Pathways that control levels of macroautophagy (, NA)
• TCR signaling pathway leading to NFKB and JNK activation (, Drosophila melanogaster,Antarctothoa delta,Homo sapiens,Mus musculus,Pseudomonas aeruginosa,Lareunionomyces loeiensis,unidentified)
• The possible mechanistic roles of platelets in cancer metastasis (, Homo sapiens,Mus musculus,Bos taurus)
• Wnt signaling (, Human gammaherpesvirus 4,Human papillomavirus,Mouse mammary tumor virus,Human papillomavirus type 16,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Mechanisms by which rotaviruses cause diarrhea (, Variola virus,Human rotavirus,Rotavirus A,Porcine rotavirus,Bovine rotavirus,Simian rotavirus A strain RRV,Rotavirus B,Simian rotavirus,Human rotavirus Ro1845,Human rotavirus HCR3A,Rotavirus G3,Bos taurus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Mus musculus,Rattus norvegicus,Chlorocebus aethiops,Lactobacillus acidophilus)
• Schematic outline of the regulation of EGFR internalization and mediated signaling by the CIN85–SH3GL2–Cbl complex (, Nicotiana tabacum,Bikinia letestui,Homo sapiens,Mus musculus,Vaccinia virus)
• Transcriptional Control of Cellular Metabolism by mTOR Signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Insulin Signaling: Inositol Phosphates Get Into the Akt (, Mus musculus,Homo sapiens)
• Signal transduction in MMTV-Pax8PPARG mice (, NA)
• Ced-1 may coordinate multiple mechanisms to link innate immunity to the Unfolded Protein Response (, NA)
• Activation of the calcineurin-NFAT pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• PPARA signaling canonical pathway in chronic arsenic-exposed lung epithelial cells (, NA)
• Proposed disease pathway in arrhythmogenic cardiomyopathy showing potential mechanisms of gap junction remodeling (, NA)
• Proposed metabolic pathway of BP-7,8-dione in three human lung cells (, NA)
• Emerging Therapies for Systemic Lupus Erythematosus - Focus on Targeting Interferon-alpha (, Homo sapiens,Mus musculus)
• Regulation of the calcineurin-NFAT pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• NFAT Gene Family in Inflammation and Cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Interaction networks of significantly regulated genes from interconnected neurons 7 days post-infarct (, NA)
• IL-33: A Novel Danger Signal System in Atopic Dermatitis (, Homo sapiens,Mus musculus,unidentified influenza virus)
• Free Radical-Producing Myeloid-Derived Regulatory Cells: Potent Activators and Suppressors of Lung Inflammation and Airway Hyperresponsiveness (, NA)
• MAPK signaling transduction in mammalian cells (, NA)
• Neuroimmune Signaling: A Key Component of Alcohol Abuse (, NA)
• Focus on Histone variant H2AX: to be or not to be (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Case 19-2010: A 35-Year-Old Man with Adenocarcinoma of the Cecum (, Homo sapiens,Diaporthe sclerotioides,NA)
• Exploring mechanisms of FGF signalling through the lens of structural biology (, NA)
• Nicotine and Pathological Angiogenesis (, NA)
• Relationship between metabolism and the autophagy machinery during the innate immune response (, Mycobacterium tuberculosis,Listeria monocytogenes,Salmonella enterica,Shigella flexneri,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development (, Homo sapiens,Mus musculus,Gallus gallus)
• Scaffolds can organize pleiotropic kinases into stimulus-specific signaling modules to direct them to one specific pathway (, NA)
• Comparison of CK2 knockout defects and Wnt pathway knockout defects, with a schema to indicate where in the pathway CK2 is believed to act (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Antibiotics doxycycline and minocycline inhibit inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi (, NA)
• Regulation of CTGF Expression by TGFB1 in OsteoblastsTGFB1 induction of CTGF in osteoblasts requires Src, Smad and ERK signaling (, NA)
• CTGF Signaling in ChondrocytesCTGF interacts with (an) unknown receptor(s) on the surface of chondrocytes via binding of one or more of its four distinct modules (, NA)
• Signaling pathways activated in cord blood-derived CD34pos hematopoietic progenitor cells (upper panel) and in erythroblasts at day 6 of differentiation (erythroblasts, lower panel) (, NA)
• Advances in targeting cell surface signalling molecules for immune modulation (, NA)
• Summary of events leading to the generation of cytosolic reactive oxygen species (ROS) (R1) and mitochondrial ROS (R2) (, Mus musculus,Rattus norvegicus,Homo sapiens)
• The signaling pathways regulating radiation-induced bystander effects through expression and secretion of soluble biologically active factors (, NA)
• Aiding and Abetting Cancer: mRNA export and the nuclear pore (, Human immunodeficiency virus,Vesicular stomatitis virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Angiogenesis signaling pathways in epilepsy (, NA)
• Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer (, Homo sapiens,Mus musculus,Human papillomavirus,Olea europaea,unidentified)
• TLR4 and chemokine receptor crosstalk (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus,Dengue virus)
• Ubiquitination-mediated regulation of interferon responses (, NA)
• NADPH Oxidase 2 Regulates Bone Marrow Microenvironment Following Hindlimb Ischemia: Role in Reparative Mobilization of Progenitor Cells (, NA)
• Signaling Pathways That Control mRNA Turnover (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Signaling Pathways That Control mRNA Turnover (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus)
• Resveratrol enhances exercise training responses in rats selectively bred for high running performance (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• Chemical genetic discovery of targets and anti-targets for cancer polypharmacology (, Saccharomyces cerevisiae,Matthiola incana,Homo sapiens,Mus musculus,Bos taurus,Drosophila melanogaster,NA)
• Highlights of 10 years of immunology in Nature Reviews Immunology (, Homo sapiens,Mus musculus,Leishmania major,Candidatus Arthromitus sp. SFB-mouse)
• Highlights of 10 years of immunology in Nature Reviews Immunology (, Homo sapiens,Mus musculus,Leishmania major,Candidatus Arthromitus sp. SFB-mouse)
• Proposed model for NV-128-induced casapase-independent cell death in OCSCs (, NA)
• Impact of Subarachnoid Hemorrhage on Parenchymal Arteriolar Function (, NA)
• miR-181b and miR-146a induced in CAFs are involved in the regulation of the NFKB signaling pathway (, NA)
• The enhanced mathematical model used to represent the Gq-mediated calcium signaling pathway (, NA)
• miRNA biogenesis pathway (, NA)
• Hedgehog Signal Transduction Network (, NA)
• These images represent the evolving picture of medicine that is driving the development of nanotechnologies for the investigation, diagnosis, and treatment of cancer (, NA)
• Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation (, Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation (, Candida dubliniensis,Sequoia sempervirens,Homo sapiens,Mus musculus)
• Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization (, NA)
• Encoding and Decoding Cellular Information through Signaling Dynamics (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Xenopus laevis,Bacillus subtilis,Coxsackievirus B3)
• CD44 Is the Signaling Component of the Macrophage Migration Inhibitory Factor-CD74 Receptor Complex (, NA)
• Effects of PEDF on cancer biology: mechanisms of action and therapeutic potential (, NA)
• Proposed intracellular effects of S100A1, S100A4, and S100A8/S100A9 (, NA)
• S100A8 induction in macrophages (, NA)
• Summary of events leading to the generation of cytosolic ROS (R1) and mitochondrial ROS (R2) (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Cerobasis alpha,Serinus sp.)
• Nitr9L–Dap12 activation of cytotoxic cells (, NA)
• Intracellular localization of Rabs (, NA)
• Rab GTPases in Membrane Traffic and Cell Physiology (, NA)
• The proposed signaling pathways for 8-iso-PGF2Alpha-mediated modulation of human platelet function (, Homo sapiens)
• Adenovirus VA RNA inhibition of both the Interferon/PKR pathway (, NA)
• ERK pathway, its upstream activators and downstream targets (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Saccharomyces cerevisiae,Human immunodeficiency virus 1,Corynebacterium phage gamma)
• Diagram illustrating the signaling mechanism of how CARD9 may be inhibiting apoptosis from TNF-alpha (, NA)
• Smooth Muscle Differentiation and Patterning in the Urinary Bladder (, Homo sapiens,Mus musculus,Paraechinus aethiopicus)
• Summary of the effects of increased dietary fat plus ethanol on the AMPK pathway and expression of enzymes involved in fatty acid synthesis (, NA)
• Anticoagulant and cytoprotective actions of the protein C pathway (, NA)
• MicroRNA and Signal Transduction Pathways in Tumor Radiation Response (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model for the integration of primary afferent, mast cell and sympathetic systems in supporting CRPS-related nociception (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Armoracia rusticana,Oryza sativa,Homo sapiens,Human alphaherpesvirus 3)
• Scheme illustrating the mechanism by which WNK4 inhibits BK channels (, NA)
• mTORC1 signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Targeting of PI3K/mTORC1 signaling in hamartoma syndromes (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Axis of ageing: telomeres, p53 and mitochondria (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• WT transcriptome data overlaid on selected metabolic pathways (, Escherichia coli)
• Transcriptional changes in TGFB1 signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Armoracia rusticana)
• Functional link between the BMP system and GnRH-induced FSH transcription (, NA)
• Cytochrome P450 1A1 Regulates Breast Cancer Cell Proliferation and Survival (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Salvia rosmarinus)
• Interactions between nTreg (A) or IL-2 activated inducible Treg (Tr1) with effector T cells (Teff) mediated by the adenosine and PGE2 pathways (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Schematic depicting the canonical and noncanonical TGFB signaling systems coupled to EMT in MECs (, NA)
• Negative feedback and adaptive resistance to the targeted therapy of cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster)
• Regulation of cytoplasmic mRNA decay (, NA)
• Th17 cell based vaccines in mucosal immunity (, NA)
• Intrinsic and ER pathways of apoptosis (, NA)
• TRAIL-mediated extrinsic pathway of apoptosis (, NA)
• Therapeutic targeting of caspase activation signaling.Ligand binding to death receptors (extrinsic pathway) results in death initiation signaling complex activation and signaling through initiator caspase 8 (, Mus musculus,Rattus norvegicus,Gallus gallus,Adeno-associated virus,Triportheus paranensis,Chicken anemia virus,Homo sapiens,Justicia procumbens)
• Regulation of Iron Absorption in Hemoglobinopathies (, Homo sapiens,Mus musculus)
• Dmrt genes integrate sex-specific, spatial, and temporal cues to induce sexually dimorphic differentiation in restricted groups of cells (, NA)
• Canonical and noncanonical TGFB signaling systems activated during mammary tumorigenesis (, NA)
• Cripto/GRP78 modulation of the TGFB pathway in development and oncogenesis (, NA)
• Proposed mechanism for fatty acid-mediated modulation of endothelial cell activation induced by TNFA (, NA)
• Examples of ciliary chemo-, photo-, and mechanotransduction (, NA)
• EIF4F-signaling pathway (, Nicotiana tabacum,Aglaia foveolata,Homo sapiens,Mus musculus,Escherichia coli,Danio rerio)
• IGF pathway (, NA)
• Molecular events in cholangiocarcinogenesis (, NA)
• Anticancer effects of resveratrol – Modulation of transcription factors (, NA)
• PI3K/Akt/mTOR pathway (, NA)
• Signaling Mechanisms in Mammalian Myoblast Fusion (, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster,Candida dubliniensis)
• Neurofibromatosis Type 2 Protein, NF2: An uncoventional cell cycle regulator (, NA)
• Genetic and molecular control of Osterix in skeletal formation (, NA)
• Lipids and Prostate Cancer (, Zea mays,Olea europaea,Helianthus annuus,Carthamus tinctorius,Prunus dulcis,Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Metabolic pathway for disulfiram in humans (, Diaporthe sclerotioides,Matthiola incana,Homo sapiens,Human immunodeficiency virus 1,clinical samples)
• Dose-dependent MeHg-induced gene expression alterations within the Wnt-signaling pathway (, NA)
• Cooperative role of ROS and NO in angiogenesis (, NA)
• Leukocyte recruitment to sites of injury/infection: dominant role of ROS (, NA)
• Signaling axis exploited in the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutant mouse model of prostate tumorigenesis (, Mus musculus,Rattus norvegicus,Betapolyomavirus macacae,Avian sarcoma virus,Homo sapiens,Drosophila melanogaster,Punavirus P1)
• TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO (, Drosophila melanogaster,Caenorhabditis elegans,Metadinium medium,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Toll-Like Receptor 4-Myeloid Differentiation Factor 88 Signaling Contributes to Ventilator-induced Lung Injury in Mice (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• Immunomodulatory functions of type I interferons (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,unidentified influenza virus,Vaccinia virus,Encephalomyocarditis virus,Yellow fever virus,ssRNA viruses,Myxoma virus,dsRNA viruses,Escherichia coli,Mycobacterium tuberculosis,Listeria monocytogenes,Vibrio cholerae,Citrobacter rodentium,Francisella tularensis,Lactobacillus acidophilus,Chlamydia muridarum,Triticum aestivum,Hordeum vulgare,Candida albicans 11C,Candida albicans 28A,Mus musculus,Cricetulus griseus,Homo sapiens,Oryctolagus cuniculus,NA)
• Post-Translational Regulation of Beta-Catenin Protein by Notch.Notch can negatively regulate active Beta-catenin levels in a non-canonical fashion (, NA)
• Target-derived NGF mediates axon growth and synapse assembly in sympathetic neurons via endocytic signaling mechanisms (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Corynebacterium phage gamma)
• The cAMP response element binding protein (CREB)-CCAAT enhancer binding protein (C/EBP) pathway activated during memory formation (, NA)
• Cellular Senescence and Cancer Chemotherapy Resistance (, Homo sapiens,Mus musculus)
• miRNAs and estrogen action (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens)
• Role of COX in human disease (, Bos taurus,Oryctolagus cuniculus,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Helicobacter pylori,Simkania negevensis,Homo sapiens,Nicotiana tabacum)
• PATHWAYS IN MICROBE-INDUCED OBESITY (, NA)
• Musashi1 (Msi1)-dependent activation of Wnt and Notch pathways as well as of proliferation in the intestinal progenitors (, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Drosophila melanogaster)
• Proposed model illustrating the effects of reduced TH in thyroid cancer development in ThrbPV/PV-PTU mice (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Mutations causing susceptibility to intestinal inflammation (, Klebsiella pneumoniae,Bacteroides fragilis,Proteus mirabilis,Helicobacter hepaticus,Homo sapiens,Mus musculus,Bos taurus,Nicotiana tabacum)
• Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling (, NA)
• Cellular Metabolic and Autophagic Pathways: Traffic Control by Redox Signaling (, NA)
• Aldose Reductase Inhibition Enhances TRAIL-Induced Human Colon Cancer Cell Apoptosis through AKT/FOXO3a-dependent upregulation of Death Receptors (, Bos taurus,Oryctolagus cuniculus,Diaporthe sclerotioides,Vasconcellea candicans,Homo sapiens,Mus musculus,Mycobacterium tuberculosis variant bovis BCG,NA)
• Molecular mechanisms of cellular insulin resistance in muscle and liver (, NA)
• Two mechanisms of phase II xenobiotic-metabolizing enzyme induction by phase II inducers (, NA)
• Pattern Recognition Receptors in Intestinal Inflammation (, NA)
• Pattern Recognition Receptors in Intestinal Inflammation (, NA)
• HIV-1 extracellular Vpr action on astrocytic functions (, Mus musculus,Rattus norvegicus,Human immunodeficiency virus 1,Human immunodeficiency virus,Homo sapiens,Saccharomyces cerevisiae,synthetic HIV-1)
• Cell signaling pathways involved in ischemic postconditioning (, NA)
• Innate Immune Responses in Hepatitis C Virus Infection (, NA)
• Innate Immune Responses in Hepatitis C Virus Infection (, NA)
• Building Robust Functionality in Synthetic Circuits Using Engineered Feedback Regulation (, Saccharomyces cerevisiae,Arabidopsis thaliana,synthetic gene,synthetic construct,Homo sapiens,Mus musculus,Escherichia coli,Xenopus laevis)
• Simplified scheme of the pathways of complement activation (, Mus musculus,Cavia porcellus,Homo sapiens,Nicotiana tabacum,Human gammaherpesvirus 4,NA)
• TGFBeta-mediated signaling and transcriptional regulation in pancreatic development and cancer (, NA)
• Neural and Cellular Mechanisms of Fear and Extinction Memory Formation (, NA)
• TGFBeta-mediated signaling and transcriptional regulation in pancreatic development and cancer (, NA)
• MYC on the Path to Cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Gallus gallus,Avian myelocytomatosis virus 29)
• Schematic model for mechanical force-induced glomerular podocyte apoptosis (, NA)
• Kaposi’s Sarcoma-Associated Herpesvirus G Protein Coupled Receptor: Lessons on Dysregulated Angiogenesis from a Viral Oncogene (, NA)
• Mechanism of action of GW583340 in sensitive (a) and acquired resistance (b) IBC models (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Meleagris gallopavo)
• Lessons from mathematically modeling the NFKB pathway (, NA)
• MLCK signaling in endothelial hyperpermeability (, NA)
• miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients (, Homo sapiens,Mus musculus,Bos taurus,Sequoia sempervirens)
• Déjà vu: EGF receptors drive resistance to BRAF inhibitors (, Homo sapiens)
• An NFKB p65-cIAP2 Link is Necessary for Mediating Apoptotic Resistance to TNFA in Gliomas (, NA)
• Tyrosine kinase (TYK) targeting growth factor and proliferation pathways (, NA)
• Working model for how ERA may modulate signaling by TLR-activated DCs (, NA)
• Molecular Pathways: The Role of Primary Cilia in Cancer Progression and Therapeutics with a Focus on Hedgehog Signaling (, Mus musculus,Rattus norvegicus,Lareunionomyces loeiensis,Chlamydomonas reinhardtii,Homo sapiens,Deinocerites cancer)
• Diacylglycerol kinases in immune cell function and self-tolerance (, NA)
• Diacylglycerol kinases in immune cell function and self-tolerance (, NA)
• Angiogenesis pathway of FAK, EZH2 and Dll4/Notch in cancer-associated endothelial cells (, NA)
• Exocyst Sec10 is Involved in Basolateral Protein Translation and Translocation in the Endoplasmic Reticulum (, NA)
• Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways (, NA)
• Schematic diagram summarizing the signaling pathways relevant to this study (, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Gene expression in keratinocytes related to IL-1 signaling (, Mus musculus,Rattus norvegicus,Subgroup C,Feline leukemia virus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster)
• Bioenergetics-EMT-cancer initiating cell axis in the pathogenesis of epithelium-originated carcinomas: a roadmap in the pursuit of targeted chemo-prevention (, Olea europaea,Taraxacum officinale,Homo sapiens,Mus musculus)
• Omics-Based Molecular Target and Biomarker Identification (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed model of Cr(VI)-induced carcinogenesis (, NA)
• Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Francisella tularensis,Legionella pneumophila,Francisella tularensis subsp. novicida,Burkholderia pseudomallei,Burkholderia thailandensis,Mus musculus,Rattus norvegicus,Dengue virus,West Nile virus,Homo sapiens)
• PI3K/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice (, Mus musculus,Rattus norvegicus,Homo sapiens)
• New insights into the biological effects of anthrax toxins: linking cellular to organismal responses (, NA)
• Signal integration by mTORC1 coordinates nutrient input with biosynthetic output (, NA)
• RB1 pathway indicating genes with mutations in this series (, Mus musculus,Rattus norvegicus,Homo sapiens)
• PI(3)K-Dependent Upregulation of Mcl-1 by Human Cytomegalovirus is Mediated by Epidermal Growth Factor Receptor and Inhibits Apoptosis in Short-Lived Monocytes (, Mus musculus,Mycobacterium tuberculosis,Cricetulus griseus,Mycobacterium leprae,Homo sapiens,Armoracia rusticana,Capra hircus,Human betaherpesvirus 5)
• Classical example of NFKB is the heterodimer of p50 and p65 and the classical activation pathway entails the release from its association with an inhibitory molecule of the IKB family (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Sus scrofa domesticus,Mus musculus,Rattus norvegicus,Candida dubliniensis,Schizosaccharomyces pombe,Homo sapiens,prion,Petrocephalus catostoma)
• Illustration of the hypoxia-inducible factor (HIF) activation pathway, highlighting hydroxylation and acetylation of HIF-1A depending on cellular oxygen tension, that is, normoxia and hypoxia (, Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Sus scrofa domesticus,Mus musculus,Rattus norvegicus,Candida dubliniensis,Schizosaccharomyces pombe,Homo sapiens,prion,Petrocephalus catostoma)
• Proposed model outlining the role of PPARD in the modulation of the radiation-induced proinflammatory response in BV-2 cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Dipturus trachyderma)
• Chemopreventive potential of natural compounds in head and neck cancer (, Nicotiana tabacum,Glycine max,Solanum lycopersicum,Olea europaea,Arachis hypogaea,Curcuma longa,Camellia sinensis,Spinacia oleracea,Brassica oleracea,Daucus carota,Punica granatum,Salvia rosmarinus,Apium graveolens Dulce Group,Carica papaya,Citrullus lanatus subsp. vulgaris,Thymus vulgaris,Origanum vulgare,Polygonum cuspidatum,Mentha x piperita,Psidium guajava,Mus musculus,Rattus norvegicus,Homo sapiens)
• Sumoylation and regulation of cardiac gene expression (, Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans,Human betaherpesvirus 5)
• BRCA1 functions independently of homologous recombination in DNA interstrand cross-link repair (, NA)
• mTOR couples cellular nutrient sensing to organismal metabolic homeostasis (, NA)
• Inhibitory molecules and therapeutic targets within the Rhopathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Diaporthe sclerotioides,Clostridium botulinum)
• DDR-adapted model in meiotic silencing (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Equus caballus,Schizosaccharomyces pombe,Metatheria,Homo sapiens,Gallus gallus)
• Targeting TGFB signaling in cancer (, NA)
• TGFB signalling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• TG2-containing adhesive/signaling complexes on the cell surface (, NA)
• The mechanism by which the EGF-induced DMR signal is mediated in UPCI-37B SCCHN cells and its application for HTS of EGFR pathway inhibitors (, NA)
• FGF signalling: diverse roles during early vertebrate embryogenesis (, NA)
• Wnt/Ctnnb1 signaling pathway is involved in self-renewal of leukemic stem cells (, Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis)
• Mechanisms Modulating Inflammatory Osteolysis: A Review with Insights into Therapeutic Targets (, NA)
• Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression (, Saccharomyces cerevisiae,Arabidopsis thaliana,Triticum aestivum,Hordeum vulgare,Allium sativum,Momordica charantia,Anacardium occidentale,Drosophila melanogaster,Caenorhabditis elegans,Apis mellifera,gut metagenome,human metagenome,Homo sapiens,Mus musculus)
• Alcohol Consumption Improves Insulin Signaling in the Myocardium (, NA)
• Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma (, Homo sapiens,Mus musculus,Human papillomavirus type 16,Derris trifoliata)
• Wnt/Beta-catenin signaling pathway (, NA)
• Role of DMP1 and its future in lung cancer diagnostics (, NA)
• Pim kinase targets and their roles in inflammation and cancer (, NA)
• Crosstalk Between Reverse Cholesterol Transport and Innate Immunity (, NA)
• Chromatin Recruitment of DNA repair proteins: Lessons from the Fanconi Anemia and Double Strand Break Repair Pathways (, NA)
• Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Hepatitis B virus,Listeria monocytogenes,NA)
• Cellular metabolism and disease: what do metabolic outliers teach us? (, NA)
• Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure (, NA)
• Endosomal network and the multivesicular bodies (MVBs) pathway (, NA)
• Road to transplant tolerance is paved with good dendritic cells (, NA)
• Recombination-independent interstrand crosslink repair pathway in vertebrates (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli,Drosophila melanogaster,Xenopus laevis,Human papillomavirus)
• Plasma Cells For Hire: Prior Experience Required (, Homo sapiens,Mus musculus,Gallus gallus)
• Treatment advances in neonatal neuroprotection and neurointensive care (, Mus musculus,Rattus norvegicus,Homo sapiens,Ovis aries,Punica granatum,Taxila haquinus)
• Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Danio rerio,Sus scrofa)
• Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (, NA)
• Intestinal permeability defects: Is it time to treat? (, Mus musculus,Rattus norvegicus,Cavia porcellus,Canis lupus familiaris,Sus scrofa,Homo sapiens,Gallus gallus,Candidatus Arthromitus sp. SFB-mouse,Trichuris suis)
• cAMP is a universal second messenger (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Mus musculus,Rattus norvegicus,Theobroma cacao,Vasconcellea candicans,Homo sapiens,Sar)
• Normal complement activation cascade and its regulation (, Homo sapiens)
• Chronic alcohol exposure alters gene expression in HepG2 cells (, NA)
• Chronic alcohol exposure alters gene expression in HepG2 cells (, NA)
• Key mutational and therapeutic targets in melanoma (, NA)
• Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury following cerebral ischemia in mice (, NA)
• When Ubiquitin Meets NFKB: A trove for anti-cancer drug development (, NA)
• Signaling pathway and proposed sites of arsenite perturbation (, Bos taurus,Oryctolagus cuniculus,Homo sapiens,Mus musculus)
• Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia (, NA)
• Simplified schematic of the cAMP/CREB signaling pathway (, NA)
• Cell Death in Disease: Mechanisms and Emerging Therapeutic Concepts (, NA)
• Summary of major signal transduction pathways downstream of chemokine receptors (, NA)
• Pathway interactions among HGF/c-Met, PI3K/Akt, and Notch signaling pathways (, NA)
• Upregulation of HER3 and resistance to anti-HER2 therapies (, NA)
• Proposed regulation of cardiac Per2 (, NA)
• Inborn Errors of Human JAKs and STATs (, NA)
• Tbx1 Regulates Progenitor Cell Proliferation in the Dental Epithelium by Modulating PITX2 Activation of p21 (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Expanding roles for CD4+ T cells in immunity to viruses (, Human immunodeficiency virus 1,Influenza A virus,Human alphaherpesvirus 1,unidentified influenza virus,Dengue virus,Respiratory syncytial virus,Vesicular stomatitis virus,Vaccinia virus,West Nile virus,Ebola virus,Enterovirus C,Human alphaherpesvirus 2,Murid betaherpesvirus 1,Murine hepatitis virus,Yellow fever virus,Venezuelan equine encephalitis virus,Theilers encephalomyelitis virus,Homo sapiens,Mus musculus,Listeria monocytogenes,NA,NA,NA,NA,NA)
• Dietary compounds on extrinsic and intrinsic pathways of apoptosis (, NA)
• Map of molecular interactions involving GADD45 proteins and cell signaling pathways generated using Ingenuity Pathway Analysis software (IPA) (, NA)
• Duo/Cdc42 pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Sesamum indicum)
• Schematic model for inhibition of cell proliferation by EGCG analogs (, Homo sapiens,Mus musculus,Bos taurus,Capsicum frutescens)
• Fat side of Prostate Cancer (, NA)
• Fat side of Prostate Cancer (, NA)
• Immunohistochemical Staining, Laser Capture Microdissection and FASP Assisted Proteomic Analysis of Target Cell Populations within Tissue Samples (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,clinical samples)
• Transcriptional regulation of effector and memory CD8+ T cell fates (, NA)
• Transcriptional regulation of effector and memory CD8+ T cell fates (, NA)
• Cancer metabolism: fatty acid oxidation in the limelight (, NA)
• mTOR signaling in growth control and disease (, Drosophila melanogaster,Caenorhabditis elegans,Cerobasis alpha,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Human immunodeficiency virus 1,prion)
• Proposed model of TRP47 effector function in E (, NA)
• Interleukin-17 Enhancement of the Interleukin-6 Signaling Cascade in Astrocytes (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Influenza A virus)
• Pathway diagram of the CTLA4 signaling in cytotoxic T lymphocytes from the IPA (, Homo sapiens)
• PHLPP suppresses the PI3K/Akt signalling pathway (, Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Cerobasis alpha,Homo sapiens,Saccharomyces cerevisiae)
• Computational framework of 3D vascularized bone regeneration within a porous biodegradable CaP scaffold (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Allium schoenoprasum)
• Pathway analysis depicting cytokine and cytokine receptor interactions relative to position in the cellular environment (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Reducing Sphingolipid Synthesis Orchestrates Global Changes to Extend Yeast Lifespan (, Saccharomyces cerevisiae,Saccharomyces cerevisiae BY4741,Saccharomyces cerevisiae CAT-1,Saccharomyces cerevisiae BY4743,Homo sapiens,Mus musculus,Corynephage beta)
• Scopolamine rapidly increases mTORC1 signaling, synaptogenesis, and antidepressant behavioral responses (, NA)
• Clathrin-dependent and -independent endocytosis of STx (, Escherichia coli,Escherichia coli O157H7,Shigella dysenteriae,Shigella dysenteriae 1,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways (, NA)
• Four major signaling pathways in the postsynaptic region of a neuron that combine to form a local signaling network (, NA)
• Phosphorylation events and the modulation of aquaporin 2 cell surface expression (, Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis,Ovis aries,Human alphaherpesvirus 3)
• Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer (, NA)
• Role of mTOR Inhibition in Preventing Resistance and Restoring Sensitivity to Hormone-Targeted and HER2-Targeted Therapies in Breast Cancer (, NA)
• TGFB signaling pathway and its integration with other major pathways that is likely to be involved in the pathogenesis of cardiovascular diseases in elderly patients (, NA)
• CTLA4Ig inhibits effector T cells through regulatory T cells and TGFB (, NA)
• Influence of Metabolism on Epigenetics and Disease (, NA)
• Top panel: In normal and during cholestatic injury, histamine receptors are found in small and large cholangiocyte populations (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Glucose, fatty acid (FA) and glutamine metabolic pathways (, Bos taurus,Sus scrofa,Ovis aries,Mus musculus,Cricetus cricetus,Homo sapiens,Saccharomyces cerevisiae)
• Development of the Bile Ducts: Essentials for the Clinical Hepatologist (, Mus musculus,Rattus norvegicus,Danio rerio,Xenopus laevis,Homo sapiens)
• Major elements of the canonical Wnt signaling pathway (, NA)
• Major elements of the noncanonical PCP Wnt signaling pathway (, NA)
• Major elements of the noncanonical Wnt/Ca2+signaling pathway (, NA)
• Schematic diagram illustrating the proposed interaction between CDH17 and Wnt/Beta-catenin pathway during HCC progression (, Mus musculus,Rattus norvegicus,Homo sapiens,Adeno-associated virus,murine stem cell retroviral vector,NA)
• Major elements of the Rho signaling pathway (, NA)
• CCM3 interacts with multiple signaling complexes (, NA)
• Arterial-venous and lymphatic specification in vertebrate embryo (, Gallus gallus,Danio rerio,Coturnix coturnix,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Diaporthe sclerotioides,Equus caballus)
• Schematic model depicting the proposed signaling pathway in LH/hCG-induced LHR mRNA down-regulation.Binding of ligand to LH receptor induces activation of ERK1/2 through the cAMP/PKA pathway (, NA)
• Protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2 (, Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Mus musculus)
• MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention (, NA)
• Epigenetic Regulation of SOX9 by the NFKB Signaling Pathway in Pancreatic Cancer Stem Cells (, NA)
• Pattern-recognition receptors (PRRs) recognize wear debris around loose implants (, Mus musculus,Diaporthe sclerotioides,Homo sapiens)
• GABAA receptor subunit regulation after status epilepticus (SE) (, NA)
• Differentially expressed genes (DEGs) related to the cell cycle (, NA)
• Integrative Analysis Reveals an Outcome-associated and Targetable Pattern of p53 and Cell Cycle Deregulation in Diffuse Large B-cell Lymphoma (, Homo sapiens,Mus musculus,Bikinia letestui)
• Genes identified in the phosphatidylinositol and hedgehog signaling pathways (, Homo sapiens)
• Unchaining the beast; insights from structural and evolutionary studies on TGFB secretion, sequestration, and activation (, Paracentrotus lividus,Branchiostoma lanceolatum,Deuterostomia,Bilateria,Amphimedon queenslandica,Danio rerio,Xenopus tropicalis,Tetrapoda,Gnathostomata,Mus musculus,Rattus norvegicus,unidentified influenza virus,H5N1 subtype,Homo sapiens,Bos taurus,Candida dubliniensis)
• Cracking the O-GlcNAc Code in Metabolism (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Arabidopsis thaliana,Lambdavirus lambda)
• Several key factors/signaling pathways in CSCs that are targets of phytochemicals (, NA)
• Common mechanisms for PLCE regulation of CICR in cardiac myocytes and pancreatic B cells downstream of Gs-coupled receptors (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Danio rerio,Ziziphus mauritiana)
• Metabolic actions of Rho-kinase in periphery and brain (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Gallus gallus,Xenopus laevis,Homo sapiens,Clostridium botulinum,Citrus medica)
• Glucocorticoid hormones, secreted as a result of a stressful event, enhance the consolidation of behavioral responses, including memories related to the event (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Nicotiana tabacum,Adeno-associated virus)
• Role of the PD-1 Pathway in the Immune Response (, Schistosoma mansoni,Patella vulgata,Catopsilia pomona,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Role of hypoxia and HIF2A in development of the sympathoadrenal cell lineage and chromaffin cell tumours with distinct catecholamine phenotypic features (, Mus musculus,Rattus norvegicus,Gallus gallus,Merluccius merluccius,Homo sapiens,Saccharomyces cerevisiae,Ovis aries)
• Crosstalk between glucose signaling pathways in yeast (, Saccharomyces cerevisiae,Aspergillus nidulans,Saccharomyces pastorianus,Homo sapiens)
• Proposed signaling pathway for ATP release from erythrocytes in response to exposure to low O2 (, Rattus norvegicus,Cricetus cricetus,Homo sapiens,Oryctolagus cuniculus)
• Epidermal growth factor receptor family and targeted agents (, Homo sapiens)
• Molecular mechanisms of T cell co-stimulation and co-inhibition (, NA)
• ICP10PK-mediated protection of uninfected neurons (, NA)
• Innate immune responses by Yersinia type III secretion system translocators and effectors (, Salmonella enterica subsp. enterica serovar Typhimurium,Clostridioides difficile,Yersinia pestis,Yersinia enterocolitica,Yersinia pseudotuberculosis,Homo sapiens,Mus musculus)
• Pathways linking hypoxia to CSCs and EMT in tumor aggressiveness (, Homo sapiens)
• Therapeutic targets of the androgen receptor signaling pathway (, NA)
• TGFB signaling (, NA)
• Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure (, NA)
• Comparing feedback mechanisms in morphogen signaling (, NA)
• Molecular pathogenesis and mechanisms of thyroid cancer (, NA)
• Molecular pathogenesis and mechanisms of thyroid cancer (, NA)
• Molecular pathogenesis and mechanisms of thyroid cancer (, NA)
• The Autophagy Pathway by Human Tumor Viruses (, NA)
• TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma (, NA)
• TNF signalling pathway (, Homo sapiens,Mus musculus,Escherichia coli,Filamentous phage)
• Steps in the reverse cholesterol transport pathway (, NA)
• Simplified overview of commonly mutated oncogenes, tumor suppressors, and pathways in endocrine cancer (, NA)
• mTOR and MAPK pathways (, NA)
• Phytochemistry and Biological Properties of Glabridin (, NA)
• Natriuretic Peptide Signaling and Breakdown (, NA)
• Linking Lipids to Alzheimer’s Disease: Cholesterol and Beyond (, NA)
• What do mechanotransduction, Hippo, Wnt, and TGFB have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease (, NA)
• Targeting the Metabolic Microenvironment of Tumors (, NA)
• Illustration of the proposed mechanisms underlying the crosstalk between insulin/IGF1 and IL-17 signaling pathways (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Sorbus aucuparia,Prenanthella exigua,Homo sapiens,Saimiriine gammaherpesvirus 2)
• Aryl Hydrocarbon Receptor Promotes RORGt+ ILCs and Controls Intestinal Immunity and Inflammation (, NA)
• Glucose-6-phosphate dehydrogenase in the pentose phosphate pathway (, herbal medicine,Vicia faba,Lawsonia inermis,Acalypha indica,Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus,Plasmodium falciparum)
• PLD and phosphatidic acid in the cell (, NA)
• Role of TRAF6 in RANK Signal Transduction Pathway (, NA)
• Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila (, NA)
• PI3K/Akt pathway impairment is a key feature of IR and vascular dysfunction (, Mus musculus,Rattus norvegicus,Psammomys obesus,Homo sapiens,Bos taurus,Candida dubliniensis)
• Insulin signaling (, Mus musculus,Rattus norvegicus,Psammomys obesus,Homo sapiens,Bos taurus,Candida dubliniensis)
• Coenzyme Q10biosynthetic pathway and electron transport role in the mitochondrial respiratory chain (, NA)
• Insulin, IGF-I and IGF-II binding to IR and IGF-IR (, NA)
• Gut triglyceride production (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Mesocricetus auratus,Psammomys obesus,Canis lupus familiaris,Sus scrofa,Candida dubliniensis,Cinnamomum verum,Homo sapiens)
• APE1 role in DNA base excision repair (BER) (, NA)
• Innate immune response during urinary tract infection and pyelonephritis (, Homo sapiens,Mus musculus,Escherichia coli,Epirrhoe alternata,Betapolyomavirus hominis)
• Primary therapeutic targets in the Ras downstream signaling pathway (, Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• Pheromone response pathway in Cryptococcus neoformans (, NA)
• Biology of Progesterone Receptor in the Normal Mammary gland and in Breast Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus,clinical samples)
• RSK isoforms control motility and other aspects of tumor cell invasion and metastasis (, Homo sapiens,Mus musculus,Danio rerio,Canis lupus familiaris,unidentified)
• Tangled Circuitry of Metabolism and Apoptosis (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Xenopus laevis)
• Estrogen Regulation of Dkk1 and Wnt/Beta-Catenin Signaling in Neurodegenerative Disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Xenopus laevis,Equus caballus)
• Targeting the RAS oncogene (, NA)
• Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Armoracia rusticana,Homo sapiens)
• Cartoon of the phospholipase CBeta-G protein signaling pathway (, NA)
• Diagrammatic representation of the hedgehog (Hh) signaling pathway (, Diaporthe sclerotioides,Ovis aries,Olea europaea,Paraechinus aethiopicus,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• Alcohol metabolism and putative mechanism of alcoholic lung injury (, NA)
• Serine, glycine and the one-carbon cycle: cancer metabolism in full circle (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Caenorhabditis elegans,Ricinus communis)
• Squalene Synthase Inhibitor Lapaquistat Acetate: Could Anything Be Better Than Statins? (, Homo sapiens)
• Rho GDP–Rho GTP signaling pathway from membrane to the cytosol (, NA)
• MyD-88 dependent TLR signaling pathway: MyD-88 (*) associates with the cytoplasmic domain of TLR, recruiting IRAK1 and IRAK4 to activate TRAF6 (, Homo sapiens,Bikinia letestui,NA)
• IL-33 markedly activates murine eosinophils by an NFKB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop (, NA)
• Schematic overview of multiple feedback loops in the PI3K pathway (, NA)
• Targeting Mutant Fibroblast Growth Factor Receptors in Cancer (, NA)
• Gremlin regulation of LOXs in TM (, NA)
• NLRP6 in Infection and Inflammation (, NA)
• Target genes of CDX1 and CDX2, and the BMP/TGFB signaling pathway (, NA)
• Feedback signaling following mTORC1 inhibition (, Homo sapiens,Mus musculus,NA)
• Feedback signaling following PI3K, AKT, or dual mTORC1/2 inhibition (, Homo sapiens,Mus musculus,NA)
• Growth factors, insulin, nutrients and energy status regulate the activation of the PI3K/Akt/mTOR signaling network (, NA)
• Proposed Model for EtOH and PA regulation of mTORC1 and mTORC2 signaling (, NA)
• Bcl-2 inhibition may act directly on tumor cells but may also target the nutrient supply to the tumor by disrupting the blood vessels that form around, and within, the tumor () (, Mus musculus,Rattus norvegicus,Homo sapiens,Camellia sinensis,clinical samples)
• PKCE ACTIVATION PROMOTES FGF-2 EXOCYTOSIS AND INDUCES ENDOTHELIAL CELL PROLIFERATION AND SPROUTING (, NA)
• Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management (, Malus domestica,Cucumis sativus,Allium cepa,Mus musculus,Rattus norvegicus,Homo sapiens)
• Role of B-RafV600E in differentiated thyroid cancer and preclinical validation of compounds against B-RafV600E (, Nicotiana tabacum,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Role of B-RafV600E in differentiated thyroid cancer and preclinical validation of compounds against B-RafV600E (, Nicotiana tabacum,Lareunionomyces loeiensis,Homo sapiens,Mus musculus)
• Schematic model depicting activation of the AIM2 inflammasome by F (, NA)
• n – 3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation (, NA)
• Roles for prions and protein-only inheritance in cancer (, prion,Bos taurus,Ovis aries,Mustela lutreola,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Aplysia californica,NA)
• MicroRNAs: molecular features and role in cancer (, NA)
• Ecdysteroids Elicit a Rapid Ca2+ Flux Leading to Akt Activation and Increased Protein Synthesis in Skeletal Muscle Cells (, NA)
• Outline of steps mediating androgen synthesis and metabolism in prostate cancer cells (, NA)
• Pathway based analysis of high ranking composite score genes reveals key signaling pathways associated with PDAC clinical progression (, Homo sapiens,Mus musculus,Bikinia letestui)
• Gene Array Data from CWR22RV1 xenografts treated with PD325901 for three weeks (, NA)
• Infarction Induced Myocardial Apoptosis and ARC Activation (, NA)
• Ingenuity Pathway Analysis (Ingenuity Systems, Inc., Redwood City, CA) of endothelial gene expression (, NA)
• Structure and function of GDP-mannose-3′ ,5′ -epimerase; an enzyme which performs three chemical reactions at the same active site (, Arabidopsis thaliana,Solanum tuberosum,Syringa vulgaris,Escherichia coli,Escherichia coli IS1,Homo sapiens,Tobacco etch virus)
• Towards a ‘systems’ level understanding of the nervous system and its disorders (, Mus musculus,Rattus norvegicus,Homo sapiens,gut metagenome,Bacteroides fragilis)
• Targeting Mutant BRAF in Melanoma: Current Status and Future Development of Combination Therapy Strategies (, NA)
• Targeting Mutant BRAF in Melanoma: Current Status and Future Development of Combination Therapy Strategies (, NA)
• Simplified flavonoid biosynthetic pathway showing enzymatic steps specific to the biosynthesis of nutraceutical stilbenes (RS), flavonols (FLS), proanthocyanidins (and lignin [, ], HCT) (LAR and ANR), and anthocyanins (UFGT) (, NA)
• Unfolded protein response and its regulation on cell activities (, NA)
• Viral modulation of programmed necrosis (, NA)
• PI3K/AKT/mTOR signaling pathway showing interacting activation and regulatory feedback loops (, Homo sapiens,NA)
• Targeting blood–brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery (, NA)
• Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes (, NA)
• Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate (, NA)
• Commonly mutated pathways in glioblastoma (, Homo sapiens,Mus musculus,Gallus gallus,Avian retrovirus)
• Regulation of the human catalytic subunit of telomerase (hTERT) (, NA)
• Changing the ubiquitin landscape during viral manipulation of the DNA damage response (, Human T-cell lymphotropic virus,Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,Betapolyomavirus macacae,Human adenovirus 5,Simian immunodeficiency virus,Murid herpesvirus 68,Minute virus of mice,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA,NA)
• Rac signaling in breast cancer: A tale of GEFs and GAPs (, NA)
• TNFAlpha-mediated transient IKK activation pathways (, Homo sapiens,Mus musculus)
• Crosstalk in TNFR1 signaling (, Homo sapiens,Mus musculus)
• From Evolution to Revolution: miRNAs as Pharmacological Targets for Modulating Cholesterol Efflux and Reverse Cholesterol Transport (, Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Candida dubliniensis,Chlorocebus aethiops,Mus musculus,Opsanus beta,synthetic RNA,Mycoplasma capricolum)
• Quantitative Phosphoproteomic Profiling of Human Non-Small Cell Lung Cancer Tumors (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,clinical samples)
• Role of Calcium, Vitamin D, and the Extrarenal Vitamin D Hydroxylases in carinogenesis (, NA)
• Regulation of cancer stem cells by inflammatory cytokine networks (, Homo sapiens,Mus musculus)
• Effects of Akt activation status on matrix metalloproteinase 1 (MMP1) gene expression (, Bos taurus,Oryctolagus cuniculus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana,Human adenovirus sp.)
• Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate (, NA)
• Wnt-dependent pathway responses (, Lareunionomyces loeiensis,Veratrum californicum,Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio,Capra hircus)
• In silico method for modelling metabolism and gene product expression at genome scale (, Escherichia coli,Mycobacterium tuberculosis,Bacillus subtilis,Escherichia coli IS1,Thermotoga maritima,Escherichia coli B,Thermococcus litoralis,Thermotoga maritima MSB8,Homo sapiens)
• Dual coordinated regulation of CYP7A1 by the FXR-SHP-LRH-1 and FXR-FGF15/19-FGFR4 pathways (, Xenopus laevis,Dipturus batis,Leucoraja erinacea,Mus musculus,Rattus norvegicus,Homo sapiens)
• ERK and PI3K signaling networks are shown, with illustrations of feedback loops and cross talk (, NA)
• IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Molecular events associated with tumor suppressor gene product-induced senescence or apoptotic cell death of tissue-resident stem/progenitor cells during chronological aging (, Homo sapiens)
• Rho GTPase signaling pathway (, NA)
• Role of inflammation and its mediators in acute ischemic stroke (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells (, NA)
• Circuitry and biochemical basis for Tuberous Sclerosis symptoms: From Epilepsy to Neurocognitive deficits (, NA)
• Tudor: a versatile family of histone methylation ‘readers’ (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Homo sapiens,Drosophila melanogaster)
• MAPK signalling pathway and PI3K/IP3signalling pathway in C (, Saccharomyces cerevisiae,Candida albicans,Schizosaccharomyces pombe,Cryptococcus neoformans,Neurospora crassa,Pyricularia grisea,Cryptococcus neoformans var. grubii,Cryptococcus gattii VGI,Cryptococcus neoformans var. neoformans,Cryptococcus neoformans var. neoformans JEC21,Cryptococcus sp. IS,Homo sapiens,Mus musculus,Aphyosemion alpha,Simian retrovirus 2)
• Protein Kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Arachis hypogaea,Eurosta comma)
• Protein Kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Arachis hypogaea,Eurosta comma)
• Pathway databases (, NA)
• Ductal bile modification (, NA)
• Mitochondrial Retrograde Signaling at the crossroads of tumor bioenergetics, genetics and epigenetics (, NA)
• Mitochondrial Retrograde Signaling at the crossroads of tumor bioenergetics, genetics and epigenetics (, NA)
• In addition to apoptosis, AR may also regulate other kinds of cell death (, NA)
• MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells (, NA)
• Mammalian target of rapamycin (mTOR) signaling pathway for the regulation of skeletal muscle protein synthesis in response to growth factors, nutrition, and mechanical stimuli (, Homo sapiens,Mus musculus,Rattus norvegicus,Microcebus murinus,Drosophila melanogaster,Diaporthe sclerotioides)
• Molecular chaperones in mammary cancer growth and breast tumor therapy (, NA)
• Activation of BIM by cellular stress in normal cells (, Homo sapiens,Mus musculus,Human gammaherpesvirus 4)
• Cisplatin resistance.Notes: Cisplatin creates DNA adducts and activates the apoptotic pathway, thus killing rapidly dividing cells (, NA)
• = Transporter, ◊ = Enzyme, ∇ = Kinase, ∆ = Phosphatase, = Transcription regulator, 〇 = Other, = Complex/group, = Peptidase (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Armoracia rusticana)
• New mechanisms of NOD-like receptor-associated inflammasome activation (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Bacillus anthracis,Legionella pneumophila,Yersinia pestis,Burkholderia pseudomallei,Burkholderia thailandensis,Human gammaherpesvirus 8,Encephalomyocarditis virus,Tobacco etch virus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Genomic Characterization of the Inherited Bone Marrow Failure Syndromes (, Homo sapiens,Mus musculus,Bos taurus,Danio rerio)
• Regulation of Hsp genes by HSF and FOXO (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Rattus norvegicus,Saccharomyces cerevisiae,Escherichia coli,prion)
• miRNAs that promote or inhibit tumorigenesis provide diverse functions within oncogenic and tumor suppressor signaling pathways (, NA)
• Cell Death in Heart Disease (, NA)
• Unconventional roles of kinesins in cell signaling (, Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Ustilago maydis,Homo sapiens,Mus musculus)
• Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells (, NA)
• Inhibition of the Nedd8 system sensitizes cells to DNA Inter-strand crosslinking agents (, Homo sapiens,Mus musculus)
• How both apoptotic death and immunity may be triggered by dsRNA (, NA)
• KIT/KITLG pathway in primordial and small primary follicles participates in oocyte viability and survival (, NA)
• Human epidermal growth fa ctor receptor 2 (HER2) signal transduction pathways (, NA)
• Canonical (Wnt/Beta-catenin) pathway (, NA)
• Signaling pathways interface with Wnt/Beta-catenin signaling (, NA)
• Consequences of dysregulated Wnt/b-catenin signaling on HIV replication in the CNS (, NA)
• The inverse relationship between Wnt/Beta-catenin signaling and HIV replication (, NA)
• PTEN in cancer, metabolism and aging (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Hallmarks of Aging (, NA)
• Role of apoptosis in colon cancer biology, therapy, and prevention (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Metabolism of adenosine (, NA)
• Inhibition of glycogen phosphorylation induces changes in cellular proteome and signaling pathways in MIA pancreatic cancer cells (, NA)
• Potential role for PRC in orchestrating a balance between cell cycle entry and the inflammatory response to metabolic stress (, Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Oryctolagus cuniculus,Venustaconcha ellipsiformis,Homo sapiens)
• Integration of mitochondrial oxidative and antioxidant pathways by PGC-1A (, Mus musculus,Rattus norvegicus,Bos taurus,Drosophila melanogaster,Oryctolagus cuniculus,Venustaconcha ellipsiformis,Homo sapiens)
• Intracellular effects of estrogen are exerted through two main pathways, genomic and non-genomic (, NA)
• The Potential of 11C-acetate PET for Monitoring the Fatty Acid Synthesis Pathway in Tumors (, NA)
• Targeted inhibition of BRAF kinase: opportunities and challenges for therapeutics in melanoma (, NA)
• Insights on how the Mycobacterium tuberculosis heme uptake pathway can be used as a drug target (, Staphylococcus aureus,Mycobacterium tuberculosis,Serratia marcescens,Homo sapiens)
• Toll-Like Receptors in Chronic Pain (, Escherichia coli,Staphylococcus aureus,Porphyromonas gingivalis,Mycobacterium avium,Streptococcus sp. group B,Escherichia coli 14A,Microcystis aeruginosa,Microcystis viridis CL4,Mus musculus,Rattus norvegicus,Castor fiber,Homo sapiens,Drosophila melanogaster,Gallus gallus,Human immunodeficiency virus 1,prion)
• Cancer Cells Incorporate and Remodel Exogenous Palmitate into Structural and Oncogenic Signaling Lipids (, Homo sapiens,Mus musculus,Candida dubliniensis)
• Insulin Biosynthetic Interaction Network Component, TMEM24, Facilitates Insulin Reserve Pool Release (, Mus musculus,Rattus norvegicus,Homo sapiens)
• One putative signaling pathway for cardioprotection initiated by LMW FGF2 via cMyBP-C phosphorylation (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus)
• Estrogen-induced ER-mediated pathways of vascular relaxation (, NA)
• Evidence Stacks Up that Endothelial Insulin Resistance is a Culprit in Atherosclerosis (, NA)
• Cholesterol synthesis pathway and protein prenylation (, NA)
• MAPK signaling pathway is upregulated in OSI-906 resistant CRC lines (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus)
• The IFNG signaling pathway (, NA)
• The potential role of altered cytokine-mediated signal transduction and mitochondrial metabolism in DPI- and DTI-related growth control (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Sequoia sempervirens,Citrus macrophylla,Homo sapiens,Moloney murine leukemia virus,Siproeta stelenes)
• Proposed mechanism underlying FGF-mediated inhibition of RhoA after ICH (, NA)
• XIAP mono-ubiquitylates Groucho/TLE to promote canonical Wnt signaling (, NA)
• Calcium at fertilization and in early development (, Xenopus laevis,Homo sapiens)
• Multiple feedback loops contribute to commitment and progression through meiotic cell-cycle progression (, NA)
• Proposed cellular mechanisms involved in insulin-stimulated androgen biosynthesis, PCOS-associated defects, free fatty acids-induced insulin resistance and increased androgen production, and PPARG actions (, NA)
• Rat sarcoma viral oncogene homolog (RAS) activation converts normal keratinocytes to an initiated phenotype through a series of potentially reversible autocrine signals (, NA)
• Divergent roles of myeloid differentiation factor 88 (MyD88) in colon carcinogenesis (, NA)
• Wnt/Beta-catenin signaling pathway in liver biology and disease (, NA)
• DNA repair pathway in mitochondria (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Escherichia coli,Human gammaherpesvirus 4,clinical samples)
• Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs (, Danio rerio,Xenopus laevis,Calloplesiops altivelis,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Listeria monocytogenes)
• Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection (, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human papillomavirus,unidentified influenza virus,Human papillomavirus type 16,Human gammaherpesvirus 8,Simian immunodeficiency virus,Human immunodeficiency virus 2,Homo sapiens,Macaca mulatta,Mus musculus,NA)
• Evaluating the potential of IL-27 as a novel therapeutic agent in HIV-1 infection (, Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Influenza A virus,Human papillomavirus,unidentified influenza virus,Human papillomavirus type 16,Human gammaherpesvirus 8,Simian immunodeficiency virus,Human immunodeficiency virus 2,Homo sapiens,Macaca mulatta,Mus musculus,NA)
• Microbiota impact on the epigenetic regulation of colorectal cancer (, Escherichia coli,Helicobacter pylori,Bacteroides fragilis,Lactobacillus acidophilus,Staphylococcus epidermidis,Lacticaseibacillus rhamnosus GG,Bifidobacterium breve,Helicobacter hepaticus,Escherichia coli NC101,Fasciola hepatica,Opisthorchis viverrini,Homo sapiens,Mus musculus,gut metagenome)
• Metabolic networks of longevity (, NA)
• IL-11: a prominent pro-tumorigenic member of IL-6 family (, Homo sapiens,Mus musculus)
• TGFB signaling can occur through multiple pathways (, NA)
• BTB restructuring and spermiation are coordinated by IL-1A during spermatogenesis (, NA)
• IL-1 signaling leads to actin stress fiber formation (, NA)
• Signaling pathways of NFKB activation (, NA)
• Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina (, NA)
• Canonical NFKB activation by TCR/CD28 and HTLV1 Tax (, NA)
• The Sema3A-activated signaling pathway that triggers adhesion site disassembly (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens,Dictyostelium discoideum,actinobacterium OR-12)
• Tax-specific noncanonical NFKB pathway (, NA)
• Human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone (, NA)
• Model of the signaling pathway mediated by ATM in response to DSBs induced by IR, as proposed by Kitagawa et al (, NA)
• Global Proteomics and Pathway Analysis of Pressure-overload Induced Heart Failure and Its Attenuation by Mitochondrial Targeted Peptides (, NA)
• Hippo-YAP pathway: new connections between regulation of organ size and cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,Gallus gallus)
• Ras-dependent versus Ras-independent extracellular signal-regulated kinase (ERK) signaling (, NA)
• Therapeutic Strategies to Increase Human Beta-Cell Growth and Proliferation by Regulating mTOR and GSK-3/Beta-Catenin Pathways (, NA)
• Proposed functions of Spry1 and Spry2 in regulation of eyelid closure (, Mus musculus,Gallus gallus,Homo sapiens)
• Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Basic depiction of the classical view of the PI3K signaling network (black arrows) as well as the novel signaling pathway revealed in the study by Tan et al (, Homo sapiens,Mus musculus)
• Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk (, Bos taurus,Capra hircus,Homo sapiens,Mus musculus,Moloney murine leukemia virus)
• NMNATs, Evolutionarily Conserved Neuronal Maintenance Factors (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Allium cepa,Homo sapiens,Drosophila melanogaster)
• Canonical WNT/Beta-catenin signaling and inhibitors (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Matricellular Protein Thrombospondin-1 Globally Regulates Cardiovascular Function and Responses to Stress via CD47 (, NA)
• NAD+ metabolism, a therapeutic target for age-related metabolic disease (, Saccharomyces cerevisiae,Arachis hypogaea,Reynoutria japonica,Veratrum grandiflorum,Homo sapiens,Macaca mulatta,Mus musculus,Caenorhabditis elegans,Canis lupus familiaris)
• Overall PI3K and MAPK-Erk signaling is complex, but can highly influence the balance between cell survival and death (, Mus musculus,Rattus norvegicus,Homo sapiens,Ginkgo biloba,Myxoma virus)
• Molecular Pathways: Sterols and receptor signaling in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Molecular Pathways: Sterols and receptor signaling in cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Pancreatic cancer initiation pathway for simulation setting (III) (, NA)
• Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway (, Danio rerio,Dipturus trachyderma,Homo sapiens,Mus musculus,Drosophila melanogaster,Arabidopsis thaliana)
• Schematic diagram showing the interaction between NW arenaviruses and host innate immune response (, Mus musculus,Cavia porcellus,Mastomys natalensis,Calomys musculinus,Calomys callosus,Mus setulosus,Neotoma micropus,Sigmodon alstoni,Oecomys sp.,Zygodontomys brevicauda,Myotomys unisulcatus,Necromys obscurus,Neotoma albigula,Neacomys guianae,Nephelomys albigularis,Sooretamys angouya,Arvicanthis sp.,Hylaeamys megacephalus,unidentified influenza virus,Mouse mammary tumor virus,Respiratory syncytial virus,H5N1 subtype,Ebola virus,Measles morbillivirus,New world arenaviruses,Old world arenaviruses,Morogoro mammarenavirus,Mammarenavirus allpahuayoense,Catarina virus,Dandenong virus,Gbagroube virus,Menekre virus,Homo sapiens,Macaca mulatta,Macaca fascicularis,marmosets,Argentina sphyraena,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA,NA)
• What a Tangled Web We Weave: Emerging Resistance Mechanisms to Inhibition of the Phosphoinositide 3-kinase Pathway (, NA)
• CD4 T-cell immunotherapy for chronic viral infections and cancer (, NA)
• Ubiquitylation in immune defence and pathogen evasion (, NA)
• Ubiquitylation in immune defence and pathogen evasion (, NA)
• Yin and Yang of PDGF-mediated signaling pathway in the context of HIV infection and drug abuse (, NA)
• Computational Model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking (, NA)
• Conversion of ω6 and ω3 series PUFA by metabolic enzymes and interaction with de novo fatty acid synthesis (, NA)
• Main enzymes and G protein-coupled receptors in the cyclooxygenase pathway (, NA)
• The FBXL2- and PTPL1-dependent regulation of the PI(3)K pathway (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,NA)
• Citrobacter Infection and Wnt signaling (, Escherichia coli,Helicobacter pylori,Clostridioides difficile,Campylobacter jejuni,Fusobacterium nucleatum,Citrobacter rodentium,Salmonella enterica subsp. enterica serovar Typhi,Clostridioides difficile CD3,Escherichia coli IS5,Helicobacter hepaticus,Pasteurella multocida,Citrobacter freundii,Streptococcus equinus,Hathewaya histolytica,Streptococcus gallolyticus,Bartonella bacilliformis,Lawsonia intracellularis,Citrobacter rodentium ICC168,Homo sapiens,Mus musculus,Drosophila melanogaster,Lareunionomyces loeiensis,human gut metagenome)
• Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (, NA)
• Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (, NA)
• O-linked N-acetylglucosamine (O-GlcNAc) is a nutrient sensor and underlies glucose toxicity (, Saccharomyces cerevisiae,Arabidopsis thaliana,Triticum aestivum,Aspergillus niger,Aspergillus niger SH-2,Human immunodeficiency virus 1,Adenoviridae,Human betaherpesvirus 5,Autographa californica nucleopolyhedrovirus,Drosophila melanogaster,Caenorhabditis elegans,Giardia intestinalis,Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Danio rerio,Listeria monocytogenes,Opsanus beta,Streptococcus sp. group A,Homo sapiens)
• Regulation of insulin sensitivity by electrophiles through adduction and inhibition of PTP1B (, NA)
• Molecular regulation of autophagy (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens)
• Ingenuity Pathway Analysis of genes that are differentially methylated (P<1.8 × 10−6) between normal mucosa of cancer patients and controls (, Homo sapiens)
• Targets of immunosuppressive drugs used in solid organ transplantation, according to the 3-signal model of T-cell activation (, NA)
• Molecular Pathways: Beta-adrenergic signaling in cancer (, NA)
• Suppression of the NFKB Pathway by Diesel Exhaust Particles Impairs Human Antimycobacterial Immunity (, NA)
• Brain Reward Circuitry in Mood Disorders (, NA)
• Regulated in DNA Damage and Development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1) (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Bos taurus,Drosophila melanogaster,Xenopus laevis)
• Death receptors and the extrinsic pathway of apoptosis (, NA)
• Molecular basis for synergistic activation through pairs of coactivation receptors on NK cells (, Human immunodeficiency virus 1,Human betaherpesvirus 5,Vaccinia virus,Enterovirus C,Murid betaherpesvirus 1,Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus,Corynebacterium phage gamma,NA)
• Protein components of the pheromone response network constructed by the PCST approach (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Escherichia coli,Acanthamoeba polyphaga mimivirus)
• Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses (, Drosophila melanogaster,Caenorhabditis elegans,Enterococcus faecalis,Neisseria gonorrhoeae,Anopheles gambiae,Aeromonas hydrophila,Aliivibrio fischeri,Acyrthosiphon pisum,Patinopecten sp.,Hydra vulgaris,Buchnera aphidicola,Lymantria dispar,Euprymna scolopes,Aeromonas salmonicida,Sodalis glossinidius,Hirudo medicinalis,Biomphalaria glabrata,Serratia symbiotica,Aeromonas veronii,bacterium V,Candidatus Hamiltonella defensa,Sepia officinalis,Candidatus Regiella insecticola,Aeromonas salmonicida subsp. salmonicida,Hydra oligactis,Aeromonas veronii bv. sobria,Hirudo verbana,Theromyzon tessulatum,Homo sapiens,Mus musculus,gut metagenome,Dengue virus,cellular organisms,Gnathostomata,Afrothismia hydra)
• Photoreceptor cell death and rescue in retinal detachment and degenerations (, NA)
• Hypoxia inducible factor pathway inhibitors as anticancer therapeutics (, NA)
• Schematic diagram illustrating central role for ROS and Src in hypoxia-induced pY654-Beta-catenin/HIF1A formation and tumor EMT (, NA)
• Histone modifications: implications in renal cell carcinoma (, NA)
• In vivo astrocytic Ca2+ signaling in health and brain disorders (, NA)
• Transcriptome Analysis of Human Injured Meniscus Reveals a Distinct Phenotype of Meniscus Degeneration with Aging (, Candida dubliniensis,Lotus berthelotii,Homo sapiens,Mus musculus,Drosophila melanogaster,Oryctolagus cuniculus,Xenopus laevis,Mouse mammary tumor virus)
• Network pathway analysis integrated the majority of proteins identified as changed on 2DE (), as shown in but did not include S-methyl-5`thioadenosine phosphorylase, and lamin B1 because of low scoring (, NA)
• Schematic diagram illustrating the canonical insulin signaling pathway (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,NA,NA)
• Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,NA,NA)
• Targeting the EGFR signaling pathway in cancer therapy (, Mus musculus,Rattus norvegicus,Glycine max,Diaporthe sclerotioides,Homo sapiens)
• Targeting the EGFR signaling pathway in cancer therapy (, Mus musculus,Rattus norvegicus,Glycine max,Diaporthe sclerotioides,Homo sapiens)
• Many potential signaling pathways for adiponectin in endothelial cells (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca mulatta,NA,NA)
• Deconvoluting the Obesity and Breast Cancer Link: Secretome, Soil and Seed Interactions (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Signaling cross-talk at the various levels of EGFR/HER2 signaling pathways (, Homo sapiens,Mus musculus,clinical samples)
• Cross-talk of EGFR/HER2 signaling with other pathways (, Homo sapiens,Mus musculus,clinical samples)
• An outline of the GPI and GPI-anchored protein biosynthetic pathway (, Trypanosoma cruzi,Trypanosoma brucei,Homo sapiens,Saccharomyces cerevisiae,Staphylococcus aureus,prion)
• EGFRvIII represses the Erk pathway and preferentially activates the PI3K/Akt pathway (, Homo sapiens,Mus musculus,Bos taurus)
• Cav-1 phosphorylation-dependent LPS signaling pathway in mediating lung inflammation in endothelial cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Escherichia coli,Oryctolagus cuniculus)
• SIRT3: as simple as it seems? (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• FOXO transcription factors throughout T cell biology (, NA)
• MDA-7 interferes with tumor promoting pathways (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Armoracia rusticana,Matthiola incana,Homo sapiens,Mus musculus)
• Regulation of the mTOR signaling pathway (, NA)
• MTOR pathway and epilepsy (, Mus musculus,Rattus norvegicus,Homo sapiens)
• PKG regulation of TRPC current and signaling (, NA)
• Invasion gene signaling networks (GSNs) of (A) chronic CNT-exposed and (B) chronic asbestos-exposed MeT5A cells (, Armoracia rusticana,Matthiola incana,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Gallus gallus)
• Pathway modulations and epigenetic alterations in ovarian tumorbiogenesis (, NA)
• The muscarinic acetylcholine receptor subtypes M1–M5 (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Canis lupus familiaris,Diaporthe sclerotioides,Sar)
• Bypass Mechanisms of Resistance to Receptor Tyrosine Kinase Inhibition in Lung Cancer (, Homo sapiens,Mus musculus,NA)
• Therapeutic targets in cancer cell metabolism and autophagy (, NA)
• Schematic view of integration of TCR signal transduction with diverse components of the actin polymerization machinery (, Homo sapiens,Mus musculus)
• Signaling pathways involved in the action of A3AR agonists (, NA)
• Analysis with NIH DAVID, Princeton GO term finder and Ingenuity Pathway Analysis yield similar gene enrichments, biological processes and pathways.The high confidence hit list was also analyzed by IPA for biological pathway enrichment (, Saccharomyces cerevisiae,Escherichia coli,Matthiola incana,Escherichia coli IS1,Saccharomyces cerevisiae S288C,Escherichia coli O157H7 str. EC10,vectors,unidentified shuttle vector,Homo sapiens,Mus musculus,Human immunodeficiency virus 1,clinical samples)
• Purine biosynthetic pathway, its intermediates and energy metabolism in the cell (, NA)
• Caspase cascade (, NA)
• AKAP signaling complexes: pointing towards the next generation of therapeutic targets? (, NA)
• Regulating the Regulator: Post-Translational Modification of Ras (, NA)
• Ephrin-B cleavage and signaling (, Gallus gallus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Ephs and Ephrins in Cancer: Ephrin-A1 Signaling (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Pathway of formation and catabolism of HDL particles (, Homo sapiens,Mus musculus)
• Multiple messengers contribute to NMDAR-induced metaplasticity (, NA)
• Reactive oxygen species in cancer (, NA)
• Phytoestrogens on ECs and VSMCs (, Homo sapiens,Glycine max)
• Phytoestrogens-induced NO release from endothelial cells (, Homo sapiens,Glycine max)
• Molecular mechanism of senescence (, NA)
• Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Physiological regulation of the mTOR pathway (, NA)
• Pathological regulation of the mTOR pathway in neurological disease (, NA)
• Working models of cellular pathways giving rise to phrenic motor facilitation following AIH (, NA)
• Smoking and microRNA dysregulation: a cancerous combination (, NA)
• Proposed model for the mechanism of SHP-1–mediated inhibition of M (, Staphylococcus aureus,Mycobacterium tuberculosis variant bovis,Mycoplasmoides pneumoniae,Mycoplasmopsis fermentans,unidentified influenza virus,Respiratory syncytial virus,Adeno-associated virus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster)
• TRAIL on Trial: Preclinical advances for cancer therapy (, NA)
• Regulating intestinal function to reduce atherogenic lipoproteins (, NA)
• Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals: a review of recent research (, NA)
• Autism genes keep turning up chromatin (, Mus musculus,Rattus norvegicus,Homo sapiens,Gallus gallus)
• Regulation of Ceramide Biosynthesis by TOR Complex 2 (, NA)
• Transcription Factors in Long-Term Memory and Synaptic Plasticity (, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Carassius auratus,Serinus canaria,Taeniopygia guttata,Aplysia californica,Lymnaea stagnalis,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Transcription Factors in Long-Term Memory and Synaptic Plasticity (, Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Carassius auratus,Serinus canaria,Taeniopygia guttata,Aplysia californica,Lymnaea stagnalis,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Cardiac Aging and Insulin Resistance: Could Insulin/Insulin-Like Growth Factor (IGF) Signaling be used as a Therapeutic Target? (, Mus musculus,Rattus norvegicus,Mesocricetus auratus,Drosophila melanogaster,Drosophila repleta,Homo sapiens,Candida dubliniensis)
• Schematic illustrating numerous small molecules and biological compounds identified in the literature that inhibit Wnt/Beta-catenin signaling at various points in the pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Hepatitis B virus,clinical samples,NA)
• Additional mechanisms by which Wnt/Beta-catenin signaling can be modulated in cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Hepatitis B virus,clinical samples,NA)
• Common mechanisms by which the Wnt/Beta-catenin pathway is dysregulated in cancer (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Hepatitis B virus,clinical samples,NA)
• Schematic illustrating the Wnt/Beta-catenin pathway (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis,Hepatitis B virus,clinical samples,NA)
• Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis (, NA)
• Effects of resveratrol on a simplified signaling pathway involved in metabolic control in the liver (, NA)
• Simplified signaling pathway of the effects of resveratrol involved in metabolic control in the skeletal muscle (, NA)
• Proposed mechanisms of interaction between TLRs and MUCs: I (, Human immunodeficiency virus 1,Hepatitis B virus,Streptococcus pneumoniae,Haemophilus influenzae,Human alphaherpesvirus 2,Mycoplasmoides pneumoniae,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Gymnophalloides seoi,Homo sapiens,Candida albicans)
• Toll-like Receptors (TLRs) recognize specialized structural motifs on the microbes known as pathogen-associated molecular patterns (PAMPs) (, Human immunodeficiency virus 1,Hepatitis B virus,Streptococcus pneumoniae,Haemophilus influenzae,Human alphaherpesvirus 2,Mycoplasmoides pneumoniae,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Gymnophalloides seoi,Homo sapiens,Candida albicans)
• Neurodegenerative diseases and widespread aggregation are associated with supersaturated proteins (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Bos taurus,Escherichia coli,Caenorhabditis elegans)
• VIP tunes immune and inflammatory response by regulating multiple signaling pathways (, NA)
• Coordinating tissue interactions: Notch signaling in cardiac development and disease (, NA)
• Pathogenesis of alcoholic hepatitis with identification of newer therapeutic targets (, Homo sapiens,Mus musculus,Bos taurus,Bikinia letestui,NA)
• Redox signaling pathways regulate cardiac hypertrophy (, NA)
• Modulators of the microRNA biogenesis pathway via arrayed lentiviral enabled RNAi screening for drug and biomarker discovery (, Drosophila melanogaster,Caenorhabditis elegans,Matthiola incana,Prunus armeniaca,Homo sapiens,Mus musculus,Corvus corax,Acanthamoeba polyphaga mimivirus)
• Illustration of NFKB signaling pathway depicting classical and alternative arms (, NA)
• Polarization of immune cells in the tumour environment by TGFB (, NA)
• STAT-3: A Molecular Hub for Signaling Pathways in Gliomas (, NA)
• STAT-3: A Molecular Hub for Signaling Pathways in Gliomas (, NA)
• Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways (, NA)
• MONOGENIC AUTOINFLAMMATORY DISEASES: DISORDERS OF AMPLIFIED DANGER SENSING AND CYTOKINE DYSREGULATION (, NA)
• Comparison of in vivo (left) and in vitro (right) signaling support to the intestinal stem cell (, Homo sapiens,Mus musculus,unidentified)
• GLI1 target genes converge on a regulatory pathway that suggests roles in cell proliferation, survival and genomic stability (, NA)
• Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns to Shape the Cancer Genome (, Homo sapiens,Mus musculus,Bos taurus,Danio rerio)
• Until recently, the exact mechanism of 5-aza induced cardiomyogenesis was largely unknown and attributed to demethylation, and subsequent activation, of an unknown cardiac-related gene (, NA)
• Recapitulation of heart development can provide useful insight for optimizing differentiation protocols (, NA)
• GENETIC CONTROL OF CANDIDA ALBICANS BIOFILM DEVELOPMENT (, NA)
• Multiple pathways inducing the switch from mitosis to the endo-cycle (, NA)
• Finding a Panacea Among Combination Cancer Therapies (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Wnt signaling (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• PBK/AKT/FOSLI pathway regulating the invasive trophoblast cell lineage and trophoblast cell-directed uterine spiral artery remodeling (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signal transduction pathways leading to increased HIF-1A protein levels (, NA)
• Ewing’s Sarcoma: Overcoming the Therapeutic Plateau (, Homo sapiens,Mus musculus)
• TGFB Regulation of Gene Expression at Early and Late Stages of HPV16-Mediated Transformation of Human Keratinocytes (, NA)
• Wide variety of glycoconjugates such as heparin sulfate proteoglycan (HSPG), chondrotin sulfate proteoglycan (CSPG), N-glycosylated cystatin C, and galectins-1 are involved in signaling pathways inducing proliferation and self-renewal of NSCs (, Mus musculus,Rattus norvegicus,Homo sapiens,Campylobacter jejuni)
• Pharmacological approaches to restore mitochondrial function (, Homo sapiens,Drosophila melanogaster,Caenorhabditis elegans,Macaca mulatta,Mus musculus,Saccharomyces cerevisiae)
• Eicosanoid biosynthetic pathway (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Escherichia coli)
• Toll pathway (, Drosophila melanogaster,Anopheles gambiae,Homo sapiens)
• Synthesis of the C5 isoprenoid precursors IPP and DMAPP (, NA)
• Possible mechanisms of regulation of DP thymocytes by multiple factors (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Jak-STAT Signaling Pathway from KEGG (ID: hsa04630) overlaid with log2 fold change values using PathVisio indicating up (red) or downregulation (blue) following ART (, NA)
• Farnesoid X receptor–Acting through bile acids to treat metabolic disorders (, Zea mays,Candida dubliniensis,Humulus lupulus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms (, NA)
• Lymphotoxin Signaling in Immune Homeostasis and the Control of Microorganisms (, NA)
• Beta-catenin signaling: a novel mediator of fibrosis and potential therapeutic target (, Mus musculus,Rattus norvegicus,Homo sapiens,Lareunionomyces loeiensis,Mouse mammary tumor virus)
• Yin and Yang of PI3K vs PTEN in the regulation of beta cell proliferation (, Mus musculus,Rattus norvegicus,Homo sapiens,Hypostomus robinii)
• Family business: stem cell progeny join the niche to regulate homeostasis (, Drosophila melanogaster,Homo sapiens)
• Hypothesized schematic representation of the intracellular signaling cascade that mediates the mER-induced attenuation of ORL1 receptor- mediated spinal antinociception via rapid non-genomic mechanisms (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Middle East respiratory syndrome-related coronavirus)
• PI3K and STAT3: a New Alliance (, NA)
• Signaling pathways of the fibroblast growth factor receptor in neural stem cells (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Signaling pathways for inner ear proliferation and differentiation (, NA)
• Transmembrane signaling of IL-6, which is a major growth factor for MM (, NA)
• Molecular mechanisms involved in leptin receptor signaling in the hypothalamus (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris,Diaporthe sclerotioides)
• Steps of autophagy pathway activation (, Escherichia coli,Staphylococcus aureus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Salmonella enterica,Streptococcus pyogenes,Shigella flexneri,Mycobacterium tuberculosis variant bovis,Streptococcus sp. group A,Human immunodeficiency virus 1,Human alphaherpesvirus 1,Sindbis virus,Murine norovirus,Mus musculus,Rattus norvegicus,Toxoplasma gondii,Plasmodium berghei,Homo sapiens,Saccharomyces cerevisiae,NA)
• Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target (, Homo sapiens,Mus musculus)
• Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (, NA)
• MRE11 complex: starting from the ends (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Escherichia coli,Pyrococcus furiosus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Xenopus laevis,Middle East respiratory syndrome-related coronavirus,Tequatrovirus T4)
• MRE11 complex: starting from the ends (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Schizosaccharomyces pombe,Escherichia coli,Pyrococcus furiosus,Homo sapiens,Mus musculus,Caenorhabditis elegans,Xenopus laevis,Middle East respiratory syndrome-related coronavirus,Tequatrovirus T4)
• Canonical (A) and noncanonical (B) Wnt signaling pathway represented by KEGG analysis (, Homo sapiens,Mus musculus)
• Signaling Pathways Underlying the Pathophysiology and Treatment of Depression: Novel Mechanisms for Rapid-Acting Agents (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Diaporthe sclerotioides)
• Signaling Pathways Underlying the Pathophysiology and Treatment of Depression: Novel Mechanisms for Rapid-Acting Agents (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Diaporthe sclerotioides)
• REACTIVE OXYGEN SPECIES IN PULMONARY VASCULAR REMODELING (, NA)
• Cardiovascular Effects of Erythropoietin: An Update (, NA)
• Canonical PI3K and MAPK pathway activation determined by reverse phase protein arrays and compared between GBM subclasses: Proneural (P, purple, n=55) and Mesenchymal (M, red, n=45) (, NA)
• TGFB signaling at the BBB during acute peripheral inflammatory pain (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Homotherium serum,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Role of cytokines in Th1 and Th2 differentiation of lymphocytes (, NA)
• ErbBs/EGFR(s) signaling pathways (, Nicotiana tabacum,Curcuma longa,Citrus macrophylla,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• BRAFV600E and microenvironment in thyroid cancer: a functional link to drive cancer progression (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction (, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction (, Homo sapiens,Mus musculus,Drosophila melanogaster,NA)
• Ras oncogenes: split personalities (, Betapolyomavirus macacae,Reovirus sp.,Rat sarcoma virus,Rous sarcoma virus,Avian sarcoma virus,Harvey murine sarcoma virus,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Gallus gallus,Xenopus laevis,Broussonetia kazinoki,Homo sapiens,Bos taurus,Escherichia coli,Drosophila melanogaster)
• Metabolic map of the propionate pathway and erythromycin biosynthetic pathway (, Saccharopolyspora erythraea)
• Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy (, NA)
• Inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to AMPK activation and anti-tumor activity (, NA)
• Signalling pathways involved in smooth muscle contraction (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Ambrosia artemisiifolia)
• Transforming growth factorB (TGFB) signalling pathway (, NA)
• IGF-I regulatory system and its impact on skeletal and energy homeostasis (, NA)
• Contemporary multistep, two-dimensional model of human breast cancer progression derived from morphological, immunohistochemical, genetic and gene-expression data (, Homo sapiens,Mus musculus,clinical samples)
• Mimicking metabolic mechanisms of epigenetic regulation with small molecules (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• LPS receptor signaling pathways (, Escherichia coli,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Porphyromonas gingivalis,Haemophilus influenzae,Staphylococcus epidermidis,Moraxella catarrhalis,Salmonella enterica subsp. enterica serovar Minnesota,Human papillomavirus,unidentified influenza virus,Human papillomavirus type 16,Homo sapiens,Mus musculus,Cryptococcus neoformans)
• The Intertwined Roles of Transcription and Repair Proteins (, NA)
• Schematic diagram depicts the underlying mechanism by which LOV protects OLs from cytokine toxicity (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens)
• Kinetic changes in gene expression of selected components of the Wnt/Beta-catenin signaling pathway in aging CD8+ T cells (, Candida dubliniensis,Lareunionomyces loeiensis,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• Kinetic changes in gene expression of selected components of Th2 responses (, Candida dubliniensis,Lareunionomyces loeiensis,Sequoia sempervirens,Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• Pathophysiology of Acute Kidney Injury (, Homo sapiens)
• Schematic overview of the ABeta-Cav1.2-ptau-autophagy pathway (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Drosophila melanogaster,Ovis aries,clinical samples)
• Activation of an RTK induces dimerization and downstream phosphorylation of non-receptor tyrosine kinases (, Mus musculus,Rattus norvegicus,Homo sapiens,Corynebacterium phage gamma,Clinitrachus argentatus)
• Lipid signals and insulin resistance (, Mus musculus,Rattus norvegicus,Glycine max,Carthamus tinctorius,Homo sapiens)
• Compensatory model that is mediated by the Wnt signaling pathway and p53 in mESCs (, NA)
• Innate Immunity in the Host Defense Against intestinal Bacterial Pathogens (, NA)
• SREBPs in the innate immune response (, NA)
• Myostatin and activin signaling in muscle (, NA)
• Drosophila as a model for epithelial tube formation (, Gallus gallus,Turnagra capensis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• Pak activation by the small GTPases Rac and Cdc42 (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster,Oryctolagus cuniculus)
• Functional Relevance of Biased Signaling at the Angiotensin II Type 1 Receptor (, Mus musculus,Rattus norvegicus,Homo sapiens,Diaporthe sclerotioides)
• AEG-1/MTDH/LYRIC promotes hepatocarcinogenesis (, NA)
• Mouse embryonic stem cells undergo Charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment (, Mus musculus,Rattus norvegicus,Homo sapiens,Taxila haquinus)
• Subcellular itineraries of paradigmatic substrates of ubiquitin-dependent sorting pathways (, NA)
• DAF-12, a nuclear hormone receptor regulating development and lifespan (, Homo sapiens,Caenorhabditis elegans)
• Scaffolding Proteins: Not Such Innocent Bystanders (, NA)
• Cell death signalling regulated by the Bcl2 family (, NA)
• BH3-only proteins Bim and Bmf are subjected to multiple layers of regulation (, NA)
• Breaking bad: Manipulation of the host response by Porphyromonas gingivalis (, NA)
• Bile Acid Receptors in Non-alcoholic Fatty Liver Disease (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module (, Mus musculus,Rattus norvegicus,Escherichia coli,Escherichia coli IS1,Homo sapiens,Saccharomyces cerevisiae)
• Models of RB/E2F and RNA processing control (, NA)
• IGF-1 SIGNALING PATHWAY IN CISPLATIN-RESISTANT LUNG CANCER CELLS (, NA)
• FGF/FGFR signaling pathway (, NA)
• Key organelles and proteins involved in cellular Cu homeostasis (, NA)
• Roles of Cu in synaptic function (, NA)
• Differential effects of type I and II interferons on myeloid cells and resistance to intracellular bacterial infections (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Chlamydia trachomatis,Neisseria meningitidis,Francisella tularensis,Francisella tularensis subsp. novicida,Burkholderia pseudomallei,Chlamydia muridarum,Mus musculus,Rattus norvegicus,Homo sapiens,unidentified influenza virus)
• Dopamine and extinction: A convergence of theory with fear and reward circuitry (, NA)
• Mixed-lineage leukemia (, NA)
• NFAT proteins activate an anergy-inducing program of gene expression (, Homo sapiens,Mus musculus,Human immunodeficiency virus 1,Malus domestica)
• Wiring and firing neuronal networks: Endocannabinoids take center stage (, NA)
• Phase II Trials of Single Agent Anti-VEGF Therapy for Patients with Chronic Lymphocytic Leukemia (CLL) (, NA)
• Inflammatory cytokine Interleukin 6 (IL-6) plays an important role in hepatocarcinogenesis through the modulation of STAT3 pathway, MAPK route and cell cycle progression (, NA)
• Regulation of Hippo pathway and implications for anticancer drug development (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster)
• a) Digrammatic representation of follicle growth from the non-proliferating pool of primordial follicles (, Homo sapiens,Bos taurus,Capra hircus,Ovis aries,Macaca mulatta,Papio anubis,Mus musculus,Cricetus cricetus,Eimeria media)
• Intersection of glucose metabolism and NAD salvage (, Homo sapiens,Mus musculus)
• Wnt signaling pathway represented by KEGG analysis (, NA)
• Diagram of known egg activation pathways in Drosophila, Xenopus, and mouse (, Drosophila melanogaster,Caenorhabditis elegans,Paracentrotus lividus,Danio rerio,Xenopus laevis,Homo sapiens,Mus musculus)
• Progress in molecular-based management of differentiated thyroid cancer (, Homo sapiens,Mus musculus)
• Insights into phagocytosis-coupled activation of Pattern Recognition Receptors and Inflammasomes (, NA)
• Interactions between SOX factors and Wnt/Beta-catenin signaling in development and disease (, Drosophila melanogaster,Gallus gallus,Xenopus laevis,Paracentrotus lividus,Homo sapiens,Mus musculus)
• Interactions between SOX factors and Wnt/Beta-catenin signaling in development and disease (, Drosophila melanogaster,Gallus gallus,Xenopus laevis,Paracentrotus lividus,Homo sapiens,Mus musculus)
• Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Equus caballus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,vectors,Vesicular stomatitis virus,Raphanus sativus)
• Differentiation pathways of CSCs (, NA)
• Signaling Crosstalk: Integrating Nutrient Availability and Sex (, NA)
• Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy (, Homo sapiens)
• The HER4 signaling model, highlighting the two divergent pathways: PI3K/AKT and JAK2/STAT5a (, NA)
• RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits (, Oryctolagus cuniculus,Capra hircus,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation and effectors of the mTOR signaling pathway (, NA)
• Iron Transport Machinery of Human Cells: Players and Their Interactions (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Danio rerio,Diaporthe sclerotioides,Xenopus laevis,Subgroup C,Feline leukemia virus,Homo sapiens,Felis catus)
• Cell biological view of Toll-like receptor function: regulation through compartmentalization (, Homo sapiens,Mus musculus)
• Role of ABL Family Kinases in Cancer: from Leukemia to Solid Tumors (, NA)
• Canonical Wnt/Beta-catenin and non-canonical Wnt signaling pathways (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis,Lareunionomyces loeiensis)
• The PTEN/mTOR signaling pathway (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens)
• MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family (, Homo sapiens)
• Iron homeostasis in the liver (, NA)
• Molecular signaling pathways mediated by MET receptor tyrosine kinase in neurons (, NA)
• Canonical signal transduction cascades and mood stabilizer targets in bipolar disorder (, NA)
• Neuroprotective/apoptotic intracellular cascades at baseline and as mitigated by mood stabilizers in BD (, NA)
• Signaling abnormalities and impairment of neurotrophic cascades that underlie the neurobiological basis of bipolar disorder (, NA)
• Scheme for illustrating the effect of Naproxen on the regulation of cell cycle and apoptosis mediated through the inhibition of the PI3-K signaling pathway (, Bos taurus,Canis lupus familiaris,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens,Armoracia rusticana)
• Dissecting the Molecular Basis of the Role of the O-Mannosylation Pathway in Disease: Alpha-Dystroglycan and Forms of Muscular Dystrophy (, NA)
• Folate pathway (, NA)
• Toll, Imd and JAK-STAT immune signaling pathways (, Drosophila melanogaster,Plasmodium falciparum,Aedes aegypti,Anopheles gambiae,Plasmodium berghei,Tribolium castaneum,Plasmodium vivax,Plasmodium yoelii,Anopheles stephensi,Plasmodium falciparum 3D7,Anopheles quadrimaculatus,Plasmodium falciparum NF54,Plasmodium gallinaceum,Anopheles aquasalis,Anopheles albimanus,Plasmodium falciparum 7G8,Anopheles dirus,Plasmodium cynomolgi strain B,Saccharomyces cerevisiae,Beauveria bassiana,Capparis spinosa,Homo sapiens,Mus musculus,Escherichia coli,Dengue virus)
• Endogenous fatty acid metabolism in the control of hepatic gene transcription (, NA)
• Frizzled homolog proteins, microRNAs and Wnt Signaling in Cancer (, NA)
• Complement activation pathways (, Homo sapiens,Mus musculus,Escherichia coli,Oryctolagus cuniculus)
• MG53-mediated negative feedback regulation of skeletal myogenesis (, NA)
• Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins (, Escherichia coli,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Bacillus subtilis,Streptococcus pneumoniae,Agrobacterium tumefaciens,Pseudomonas syringae,Pseudomonas putida,Vibrio cholerae,Mycolicibacterium smegmatis,Synechocystis sp.,Acinetobacter baumannii,Bacillus thuringiensis,Ralstonia solanacearum,Thermus thermophilus,Streptococcus agalactiae,Methanocaldococcus jannaschii,Bacteroides thetaiotaomicron,Myxococcus xanthus,Burkholderia pseudomallei,Deinococcus radiodurans,Saccharolobus solfataricus,Archaeoglobus fulgidus,Burkholderia cenocepacia,Bacillus pumilus,Photorhabdus luminescens,Methanosarcina acetivorans,Mesorhizobium loti,Streptomyces fradiae,Burkholderia sp.,Methanococcus maripaludis,Synechococcus sp.,Rhodococcus opacus,Metallosphaera sedula,Gluconacetobacter diazotrophicus,Halalkalibacterium halodurans,Thiobacillus denitrificans,Bordetella petrii,Niallia circulans,Paenibacillus sp.,Brevibacillus brevis,Acidovorax sp.,Pseudoalteromonas atlantica,Methylobacterium sp.,Desulfitobacterium hafniense,Rhodospirillum centenum,Thermosynechococcus vestitus,Serratia proteamaculans,Streptomyces sviceus,Alistipes putredinis,Saccharophagus degradans,Desulforapulum autotrophicum,Rhodopirellula baltica,Verrucomicrobium spinosum,Actinosynnema mirum,Frankia alni,Actinoplanes friuliensis,Thioalkalivibrio sp.,Xanthobacter autotrophicus,Colwellia psychrerythraea,Leptospira biflexa,Gemmatimonas aurantiaca,Magnetospirillum magnetotacticum,Alkaliphilus metalliredigens,Dethiobacter alkaliphilus,Polynucleobacter necessarius,Salisediminibacterium selenitireducens,Chlorobium phaeobacteroides,Mycobacterium sp. JLS,Escherichia coli O127H6,Mycobacterium sp. KMS,Escherichia albertii,Roseiflexus sp.,Alkalilimnicola ehrlichii,Pelodictyon luteolum,Lederbergia lenta,Chloroflexus aggregans,Leptospirillum sp.,Kordia algicida,Candidatus Solibacter usitatus,Desulfonatronospira thiodismutans,Saccharomyces cerevisiae,PX clade,Olea europaea,Prunus domestica,Thalassiosira pseudonana,Stramenopiles,Homo sapiens,uncultured actinomycete,Giardia intestinalis,Bos gaurus)
• Hypothetic mechanisms of cancer therapy-induced HSC senescence and LT-BM injury and potential strategies for therapeutic intervention (, NA)
• Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches (, NA)
• Hepcidin as therapy for primary and secondary iron overload disorders: pre-clinical models and approaches (, NA)
• Induction and clearance strategies (, NA)
• PKM2 and the Tricky Balance of Growth and Energy in Cancer (, NA)
• Ras signal transduction (, Homo sapiens,Mus musculus,Syzygium aromaticum,Panthera pardus)
• Molecular mechanisms in Carney complex (CNC) and McCune-Albright syndrome (MAS): Receptor activation (ligand binding) makes GsA to exchange GDP to GTP, GsA is then freed from the BetaG dimer and activates adenyl cyclase (AC) (, NA)
• GENETICS AND EPIGENETICS OF ADRENOCORTICAL TUMORS (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Lareunionomyces loeiensis,clinical samples,Notolabrus celidotus)
• GENETICS AND EPIGENETICS OF ADRENOCORTICAL TUMORS (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Lareunionomyces loeiensis,clinical samples,Notolabrus celidotus)
• Tracking Progesterone Receptor-Mediated Actions in Breast Cancer (, Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Bikinia letestui)
• Toll-like receptors in antiviral innate immunity (, NA)
• Proteolytic pathway that controls glucose uptake in fat and muscle (, Saccharomyces cerevisiae,Arabidopsis thaliana,Komagataella pastoris,Mus musculus,Rattus norvegicus,Homo sapiens)
• Cytosolic DNA sensing pathways (, NA)
• Kidney Regeneration: Common Themes From the Embryo to the Adult (, Gallus gallus,Danio rerio,Xenopus laevis,Xenopus tropicalis,Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster)
• Bone morphogenetic protein signaling in nephron progenitor cells (, NA)
• TRIMmunity: The roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity (, NA)
• CaMKII Represses Transcriptionally-Active Beta-Catenin to Mediate Acute Ethanol Neurodegeneration and Can Phosphorylate Beta-Catenin (, Mus musculus,Rattus norvegicus,Gallus gallus,Xenopus laevis,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,Tobacco etch virus)
• Glutamate, BDNF, insulin and glucagon-like peptide 1 (GLP-1) improve neuronal bioenergetics and protect the neurons against neurodegenerative disease and traumatic injury (, Ursus maritimus,Mirounga angustirostris,Halichoerus grypus,Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Aptenodytes forsteri,Aptenodytes patagonicus,Homo sapiens,Saccharomyces cerevisiae,Escherichia coli)
• Putative role of the mTOR pathway in pathogenesis and epileptogenesis of focal cortical malformations (, NA)
• MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NFKB signaling in pancreatic cancer (, Homo sapiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Macaca mulatta,Armoracia rusticana,Salmonella enterica subsp. enterica serovar Typhimurium,Simian-Human immunodeficiency virus)
• Signal transduction events that link ER stress to inflammation (, NA)
• Illustration of the effects of mitochondrial ROS induced by NADH on the INa (, NA)
• Diagram of IGF/INSR/IGF1R signaling pathway (, NA)
• A Lipidomic Perspective on Inflammatory Macrophage Eicosanoid Signaling (, NA)
• Tumor suppressive signatures of miR-200 (, NA)
• Changing appetites: The adaptive advantages of fuel choice (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Drosophila melanogaster)
• Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes (, NA)
• Sex Differences in Anxiety and Depression: Role of Testosterone (, NA)
• Proposed signaling pathway for PCB detoxification in vivo (, Armoracia rusticana,Zea mays,Olea europaea,Camellia sinensis,Mus musculus,Rattus norvegicus,Gallus gallus,Stenotomus chrysops,Homo sapiens)
• Molecular alterations and biomarkers in colorectal cancer (, NA)
• Molecular alterations and biomarkers in colorectal cancer (, NA)
• Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism (, NA)
• The proposed model for the signaling events in mature, human oligodendrocytes in response to B. burgdorferi (, NA)
• Cellular response pathways of RPE cells upon AGE stimulation (, Homo sapiens,Bos taurus)
• Molecular pathways regulated by PGE2 that are inhibited by aspirin (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Colony-Stimulating Factors for Febrile Neutropenia during Cancer Therapy (, NA)
• N-glycan biosynthetic pathways in eukaryotes and glycoengineering (, Saccharomyces cerevisiae,Nicotiana tabacum,Nicotiana benthamiana,Komagataella pastoris,Lemna minor,Mucor hiemalis,Escherichia coli,Streptococcus pneumoniae,Campylobacter jejuni,Elizabethkingia meningoseptica,Glutamicibacter protophormiae,Homo sapiens,Human immunodeficiency virus 1,Equus caballus,Cricetulus griseus,Triportheus paranensis)
• Shear stress–induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells (, Rattus norvegicus,Homo sapiens)
• H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity (, NA)
• Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time (, NA)
• Regulation of G protein-mediated signaling by RGS2 in the heart (, Mus musculus,Rattus norvegicus,Homo sapiens,Canis lupus familiaris)
• Two major signaling pathways activated by HBV and HCV in hepatocarcinogenesis (, NA)
• Leveraging melanocortin pathways to treat glomerular diseases (, NA)
• Regulation of the life cycle of HPVs by differentiation and the DNA damage response (, NA)
• The host cell EGF signaling pathway and proteins downstream of the EGF receptor that are activated in response to C (, NA)
• Wnt/Beta-catenin signaling pathway (, NA)
• To Bud or not to Bud: The RET perspective in CAKUT (, Homo sapiens,Mus musculus,Corynebacterium phage gamma)
• TAK1 Regulates Hepatic Cell Survival and Carcinogenesis (, NA)
• TLR4 Signaling Pathway (, NA)
• JNK signaling enhances the compensatory proliferation of the neighboring cells, stem cells or cancer stem cells (CSCs) (, NA)
• FAK functions in cancer stem cells (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Canis lupus familiaris)
• FAK and tumor microenvironment Cancer cells are surrounded by cancer cell niche or tumor microenvironment components, such as extracellular matrix, endothelial cells, blood vessels; and immune cells, playing a significant role in inflammation (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Gallus gallus,Canis lupus familiaris)
• Ack1 signaling pathway in normal and cancerous cells (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Mouse mammary tumor virus)
• MEK5 regulation and downstream targets (, NA)
• MEK5/ERK5 Pathway: The first fifteen years (, NA)
• MEK5/ERK5 Pathway: The first fifteen years (, NA)
• Beta-catenin pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Matthiola incana)
• DISC1 as a key lead in studying cortical development and associated brain disorders (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Proposed signaling pathway of EGb 761-induced neuroprotection and neurogenesis (, NA)
• Tissue Factor Inflammatory Response Regulated by Promoter Genotype and p38 MAPK in Neonatal vs. Adult Microvascular Endothelial Cells (, NA)
• Targeting the Bcl-2 Family for Cancer Therapy (, NA)
• Potential crosstalk signaling pathway between PACAP and BDNF leading to neuroprotection; 1st, 2nd, and 3rd represent the three mechanisms leading to neuroprotection; arrow up—activation; arrow down—inhibition; striped line—plasma membrane (, NA)
• Invisible hand: regulation of RHO GTPases by RHOGDIs (, NA)
• Simplified model of the leptin signaling pathway (, Homo sapiens,Macaca mulatta,Callithrix jacchus,marmosets,Human adenovirus sp.,Human adenovirus 36,Human adenovirus 11p,Mus musculus,Rattus norvegicus,Caenorhabditis elegans,Gallus gallus,Olea europaea)
• Glucose and glutamine metabolism is altered by oncogenic K-Ras (, NA)
• MK-2206 Causes Growth Suppression and Reduces Neuroendocrine Tumor Marker Production in Medullary Thyroid Cancer through Akt Inhibition (, NA)
• Major components of the TGF-ß signaling pathway (, NA)
• Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity (, NA)
• Autophagy inhibition synergistically enhances anti-cancer efficacy of RAMBA, VN/12-1 in SKBR-3 cells and tumor xenografts (, Mus musculus,Cavia porcellus,Homo sapiens)
• Mitochondrial respiratory chain (, Homo sapiens,Mus musculus,Adeno-associated virus,Vasconcellea candicans)
• ATM regulates mTORC1 activity through AMPK in response to elevated ROS levels (, NA)
• ATM interaction with metabolic signaling pathways (, NA)
• Gemcitabine metabolic pathway genetic polymorphisms and response in non-small cell lung cancer patients (, Nicotiana tabacum,Eucalyptus intertexta,Bikinia letestui,Homo sapiens,unidentified,clinical samples)
• Sphingolipid Signaling and Hematopoietic Malignancies: To the Rheostat and Beyond (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Isaria sinclairii,Homo sapiens,Danio rerio,Dictyostelium discoideum)
• Schematic overview of the mTOR signaling pathway with the most important factors and their action (, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Schematic overview of the mTOR signaling pathway with the target position of drugs (, Mus musculus,Rattus norvegicus,Homo sapiens,Hepatitis B virus)
• Q43L mutant of neuregulin 2B is a pan-ErbB receptor antagonist (, NA)
• NFKB signaling pathways in osteoclast lineage cells (, NA)
• IAP antagonists and NFKB signaling in osteoclast lineage cells (, NA)
• Factors shown to promote or inhibit the vascular normalization phenotype in tumors (, Homo sapiens,Mus musculus)
• Simplified model of signaling pathways regulating protein synthesis and degradation (, Mus musculus,Rattus norvegicus,Cavia porcellus,Cricetus cricetus,Bos taurus,Oryctolagus cuniculus,Felis catus,Homo sapiens,unidentified)
• NEW STRATEGIES FOR TRIPLE NEGATIVE BREAST CANCER – DECIPHERING THE HETEROGENEITY (, NA)
• Relationships between the cellular signal pathways in HAdV-36 infected human muscle cells (, Influenza A virus,unidentified influenza virus,H5N1 subtype,Human adenovirus sp.,Human adenovirus 2,Human adenovirus 36,Homo sapiens,Saccharomyces cerevisiae,Gallus gallus,Xenopus laevis,Sequoia sempervirens,Callithrix jacchus,Mus musculus,Drosophila melanogaster)
• Reconfiguration of a signaling network upon drug treatment (, NA)
• Outside the Box Signaling: Secreted Factors Modulate GnRH Receptor-Mediated Gonadotropin Regulation (, NA)
• Signaling pathways that can be inhibited to increase the radiation response of tumors (, Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis) (, NA)
• Hypothetical mechanisms of tolerance within the TLR4 pathway (, Escherichia coli,Porphyromonas gingivalis,Cereibacter sphaeroides,Serratia marcescens,Salmonella enterica subsp. enterica serovar Minnesota,Salmonella enterica subsp. enterica serovar Abortusequi,Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Bile duct regeneration in different disease conditions (, NA)
• Integration of L-R Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2 (, NA)
• Immunopathogenesis of inflammatory bowel disease (IBD) (, Homo sapiens)
• Known components of the PCP signalling pathway and related cellular functions (, NA)
• The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs and Skin (, Homo sapiens)
• Mechanisms by which Th17 and Th22 pathways contribute to psoriasis and atopic dermatitis (, Homo sapiens)
• Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1 (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Armoracia rusticana)
• RGS proteins in the regulation of GPCR, PTH, and Wnt signaling pathways during bone remodeling (, NA)
• Cl− channels in cardiac myocytes (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Ovis aries,Cavia porcellus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,Xenopus laevis,prion,bacterium NOTE)
• Schematic description of FGF15/19-mediated repression of Cyp27 and Cyp7a1 in cholangiocytes and hepatocytes (, NA)
• Combining Immunotherapy and Targeted Therapies in Cancer Treatment (, NA)
• Drug resistance mediated by AEG-1/MTDH/LYRIC (, Homo sapiens,Mus musculus,Human immunodeficiency virus 1)
• 1A: Base excision repair (BER) pathway targets DNA damaged during replication or by environmental agents (, Saccharomyces cerevisiae,Nicotiana tabacum,Homo sapiens,Rattus norvegicus,Escherichia coli,unidentified shuttle vector)
• A) Pathogen recognition receptors RIG-I and TLR3 detect HCV ds RNA and activate via their adaptor molecules IPS-1 and TRIF (, Homo sapiens,Mus musculus,Hepatitis B virus,NA)
• Strategies for Delivery of Therapeutics into the Central Nervous System for Treatment of Lysosomal Storage Disorders (, NA)
• Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications (, NA)
• Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications (, NA)
• Self-consumption: the interplay of autophagy and apoptosis (, Drosophila melanogaster,Homo sapiens)
• Molecular pathology of FLS in RA (, Mus musculus,Rattus norvegicus,Homo sapiens,adeno-associated virus 2)
• HGF/Met receptor signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Generalized prostanoid signaling scheme (, NA)
• Many negative feedback loops in mTOR signaling (, NA)
• Schematic showing actin cytoskeleton signaling pathways in adult hippocampal spines (see ) and the proposed mechanisms by which the glucocorticoid receptor (GR) affects actin assembly and stabilization (, NA)
• Metabolic connections during apoptotic cell engulfment (, Homo sapiens,Mus musculus,Escherichia coli,Caenorhabditis elegans,Candida dubliniensis)
• Ezrin expression and cell survival regulation in colorectal cancer (, NA)
• Innovative Therapy for Classic Galactosemia - Tale of Two HTS (, NA)
• IRF signaling pathway that was generated from pathway analysis of proteins with significant fold changes across both studies (, NA)
• Tolerogenic plasmacytoid DC (, NA)
• Prominent signaling pathways involved with PDAC tumoral compartment and stromal compartment crosstalk (, NA)
• Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Human betaherpesvirus 5,H1N1 subtype,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,West Nile virus,Human alphaherpesvirus 2,Influenza A virus H3N2,Bos taurus,Capra hircus,Homo sapiens,Mus musculus,NA)
• Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication (, Human immunodeficiency virus 1,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,unidentified influenza virus,Human betaherpesvirus 5,H1N1 subtype,Human gammaherpesvirus 8,Human T-cell leukemia virus type I,West Nile virus,Human alphaherpesvirus 2,Influenza A virus H3N2,Bos taurus,Capra hircus,Homo sapiens,Mus musculus,NA)
• Best-fitting Independent pathway model, showing one twin in a pair: circles indicate variance components, and rectangles indicate observed variables (, Homo sapiens,Cuculus canorus)
• Acute and Chronic Regulation of Aldosterone Production (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Bos taurus,Diaporthe sclerotioides,Human alphaherpesvirus 1)
• Genes involved in the WNT signaling pathway (, NA)
• MicroRNA-Mediated Mechanism of Vitamin D Regulation of Innate Immune Response (, Human gammaherpesvirus 4,Avian leukosis virus,Homo sapiens,Mus musculus)
• GOLGI IN COPPER HOMEOSTASIS: A VIEW FROM THE MEMBRANE TRAFFICKING FIELD (, NA)
• Negative feedback inhibition of HER3 (, NA)
• Suppression of Farnesyltransferase Activity in Acute Myeloid Leukemia and Myelodysplastic Syndrome: Current Understanding and Recommended Use of Tipifarnib (, NA)
• TLR4 signaling pathway is highly regulated (, Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• At Loose Ends: Resecting a Double-Strand Break (, Saccharomyces cerevisiae,Schizosaccharomyces pombe,Homo sapiens,Escherichia coli)
• Pathophysiology and pharmacology of hepcidin (, Homo sapiens,Mus musculus,Rattus norvegicus,Macaca fascicularis,Brucella abortus,Mergus merganser)
• NRAS mutant melanoma: biological behavior and future strategies for therapeutic management (, NA)
• NRAS mutant melanoma: biological behavior and future strategies for therapeutic management (, NA)
• MiRNA regulation of skin fibrosis in epithelial and fibroblast cells (, Mus musculus,Rattus norvegicus,Homo sapiens,adeno-associated virus 2,Gallacea scleroderma,NA)
• Inflammasome priming by LPS is dependent upon ERK signaling and proteasome function (, NA)
• Heart Failure and Loss of Metabolic Control (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Canis lupus familiaris,Cavia porcellus,Felis catus,Saccharomyces cerevisiae,Candida dubliniensis,Homo sapiens,Drosophila melanogaster)
• PI3K pathway inhibitors for the treatment of brain metastases with a focus on HER2+ breast cancer (, Homo sapiens,Mus musculus)
• MicroRNA Regulation of T Helper Cell Differentiation and Plasticity (, NA)
• MicroRNA Regulation of T Helper Cell Differentiation and Plasticity (, NA)
• Origins and implications of pluripotent stem cell variability and heterogeneity (, Homo sapiens,Mus musculus)
• The role of sphingosine (SPH) in controlling the transactivation potential of steroidogenic factor 1 (SF-1) (, NA)
• Ingenuity pathway analysis (IPA) of the EGFR ablation signature with oncogenic (A) and wildtype Ras (B) (, Oryctolagus cuniculus,Capra hircus,Ovis aries,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy (, Homo sapiens,Hepatitis B virus,Sequoia sempervirens)
• Insulin signaling pathways that control gluconeogenesis (, Homo sapiens,Mus musculus)
• Notch signaling pathway and agents in clinical development (, Homo sapiens,Mus musculus,Drosophila melanogaster,Danio rerio)
• PGD2 pathway in alopecia (, Mus musculus,Rattus norvegicus,Homo sapiens)
• RAF activation of the MAPK/ERK pathway (, Homo sapiens,Mus musculus)
• Paradoxical activation of the MAPK/ERK pathway in tumours treated with RAF inhibitors (, Homo sapiens,Mus musculus)
• MAPK signalling cooperates with loss of APC to promote adenoma development (, Homo sapiens,Mus musculus)
• Tau Acts as a Mediator for Alzheimer's Disease-Related Synaptic Deficits (, Mus musculus,Rattus norvegicus,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis,prion)
• Diagram of putative mDA differentiation pathway based on this and other studies (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Beta-Catenin is a multifunctional protein that localizes at cell-cell contacts, the nucleus, cytosol and centrosomes (, Homo sapiens,Mus musculus,Caenorhabditis elegans,Xenopus laevis,Lareunionomyces loeiensis)
• Targeted therapy in uterine serous carcinoma: an aggressive variant of endometrial cancer (, Clostridium perfringens,Homo sapiens)
• S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment care mediated by Gi and Rac (, NA)
• Cilia in the nervous system: linking cilia function and neurodevelopmental disorders (, NA)
• Establishing the pre-placodal region and breaking it into placodes with distinct identities (, NA)
• FOLATE-ALCOHOL AND CANCER PATHWAY HYPOTHESES (, Mus musculus,Rattus norvegicus,Homo sapiens,Nicotiana tabacum)
• Copper is passed (green arrows) to cuproproteins (dark green circles), including metallothioneins Crs5 and Cup1, in for example Saccharomyces cerevisiae, by copper metallochaperones (pale green circles, or ovals if membrane associated) (, NA)
• DREAM complex: Master coordinator of cell cycle dependent gene expression (, Human papillomavirus type 16,Human gammaherpesvirus 8,Polyomavirus sp.,Woolly monkey sarcoma virus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Danio rerio,Lareunionomyces loeiensis)
• Regulation of Immune Responses by Prostaglandin E2 (, Escherichia coli,Francisella tularensis,Escherichia coli K1,Mus musculus,Bos taurus,Cavia porcellus,Felis catus,Homo sapiens)
• Signaling processes in endothelial aging in relation to chronic oxidative stress and their potential therapeutic implications (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans)
• Dendritic cells initiate T cell immunity in the lymph nodes (, Hepatitis B virus,Human papillomavirus,Respiratory syncytial virus,Mus musculus,Cavia porcellus,Bacteriophage sp.,Qubevirus durum,Homo sapiens,Bos taurus,Mycobacterium tuberculosis,Plasmodium falciparum,NA)
• Oxidative stress is a central process in the development of obesity-induced insulin resistance (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Vasconcellea candicans,Homo sapiens,unidentified influenza virus,Streptococcus pneumoniae)
• Migration of marginal zone precursor B cells regulated by type I interferon (IFN) and IL-17 (, NA)
• AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Cricetus cricetus,Physcomitrium patens,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Cricetus cricetus,Physcomitrium patens,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Arabidopsis thaliana,Cricetus cricetus,Physcomitrium patens,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,NA)
• Amino acid signalling upstream of mTOR (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Drosophila melanogaster,Hepatitis B virus)
• Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer (, Homo sapiens,Mus musculus,Human T-cell leukemia virus type I)
• Insulin effects on endothelial cells (, Mus musculus,Rattus norvegicus,Cricetus cricetus,Bos taurus,Canis lupus familiaris,Homo sapiens,Corynephage beta)
• Simplified pathway map of CCN1 and CCN2-dependent outside-in signaling pathways regulating endothelial cell function and behavior (, Gallus gallus,Xenopus laevis,Homo sapiens,Mus musculus)
• Estrogen promotes actin polymerization in CA1 dendritic spines (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Cordeauxia edulis)
• Brain-Derived Neurotrophic Factor in the Airways (, NA)
• Schematic mechanisms of hypoxia-induced collagen deposition (, Mus musculus,Rattus norvegicus,Cavia porcellus,Sus scrofa,Ovis aries,Homo sapiens,Gallus gallus)
• Partial list of AMPK targets (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Encephalitozoon cuniculi,Homo sapiens,Bos taurus,Escherichia coli,Danio rerio,NA)
• Does stress remove the HDAC brakes for the formation and persistence of long-term memory? (, NA)
• Genes identified in GWAS of Phase 1+2 AA subjects using a case-control model in the canonical pathway “calcium signaling.” The gene or gene families with a significant association result are shown in orange (, Mus musculus,Rattus norvegicus,Homo sapiens,clinical samples,Thermus aquaticus)
• Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer (, Homo sapiens,Mus musculus,Saccharomyces cerevisiae)
• Canonical BMP signaling pathway (, NA)
• Autophagic pathways in mammalian cells (, NA)
• KIT signaling pathways (, NA)
• Receptor tyrosine kinase trafficking may affect signal transduction (, NA)
• Alternatively Spliced Tissue Factor and Full-length Tissue Factor Protect Cardiomyocytes against TNF-Alpha-induced Apoptosis (, NA)
• PI3K and Cancer: Lessons, Challenges and Opportunities (, Mus musculus,Rattus norvegicus,Homo sapiens)
• PI3K and Cancer: Lessons, Challenges and Opportunities (, Mus musculus,Rattus norvegicus,Homo sapiens)
• mTOR Signaling in Cardiac Physiology and Disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Sus scrofa)
• mTOR Signaling in Cardiac Physiology and Disease (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Sus scrofa)
• Myocilin signaling in cell migration (, NA)
• Pathways for (A) Maturity Onset Diabetes of the Young (hsa04950), (B) type 2 diabetes (hsa04930), and (C) Notch signaling pathway (hsa04330); adapted from Kanehisa, et al (, Homo sapiens,Mus musculus,Ovis aries)
• Pathway analysis and molecular interactions of focus genes AKT, CTNNB1, GAB2, and SERPINE1 (hightlighted in pink) (, Homo sapiens,Mus musculus,Sequoia sempervirens)
• Treg functional stability and its responsiveness to the microenvironment (, NA)
• Proposed model (, NA)
• Overlay of significant canonical pathway and the connectivity in the molecular mechanism of cancer, with the eight genes in IPA canonical pathway and with the genes in Network (I) that differentially altered in PCB exposure (, NA)
• Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders (, NA)
• Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens (, NA)
• Origins of Metastatic Traits (, NA)
• Regulation of viperin expression (, NA)
• Metastatic Stem Cells: Sources, Niches, and Vital Pathways (, NA)
• ADVANCING AGE IS ASSOCIATED WITH GENE EXPRESSION CHANGES RESEMBLING mTOR INHIBITION: EVIDENCE FROM TWO HUMAN POPULATIONS (, NA)
• Alternatively Activated Macrophages Revisited: New Insights into the Regulation of Immunity, Inflammation and Metabolic Function following Parasite Infection (, NA)
• mTORC1 is a component of mTOR that is directly inhibited by rapamycin and rapamycin derivatives like everolimus (, NA)
• Inflammatory cytokine-associated idiosyncratic drug hepatotoxicity as a “network toxicity” (, Homo sapiens,Mus musculus)
• NRG1 signalling and neurite formation mediators (, Caenorhabditis elegans,Venustaconcha ellipsiformis,Homo sapiens,Mus musculus,Bos taurus,Human gammaherpesvirus 4,Sequoia sempervirens,Corynebacterium phage gamma)
• Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance (, NA)
• TWEAK-Fn14 Pathway: A Potent Regulator of Skeletal Muscle Biology in Health and Disease (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Metabolic, redox, and epigenomic influences of the ketogenic diet (, NA)
• Bioenergetic regulation of cellular physiology and gene expression (, NA)
• The mechanisms that lead to cell survival in MEN2A associated RET mutations that activate PI3K/Akt signaling: apoptosis suppression and enhanced cell cycle progression (, NA)
• PI3K/Akt signaling pathway is involved in several human cancers (, NA)
• Arf Family G Proteins and their regulators: roles in membrane transport, development and disease (, NA)
• TWEAK-Fn14 Pathway: A Potent Regulator of Skeletal Muscle Biology in Health and Disease (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Cholesterol as a Causative Factor in Alzheimer Disease: A Debatable Hypothesis (, NA)
• Wnt pathway and its interactions with other pathways in bone (, NA)
• The canonical Wnt, Ihh, Bmp and PTH/PTHrP signaling pathways in regulating the differentiation of mesenchymal precursors (, NA)
• Death receptor signaling and programmed necrosis (, Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Sus scrofa,Calloplesiops altivelis)
• Simplified overview of the receptor tyrosine kinase (RTK)-RAS and RAS-related RHEB signaling pathways (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Panthera pardus)
• Ischemic preconditioning (IPC): signaling pathways and targets (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Caenorhabditis elegans)
• Estrogenic Steroid Hormones in Lung Cancer (, Homo sapiens,Mus musculus,Nicotiana tabacum,unidentified)
• Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma (, NA)
• Trichloroethylene Disrupts Cardiac Gene Expression and Calcium Homeostasis in Rat Myocytes (, Rattus norvegicus,Homo sapiens)
• The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer’s model (, Mus musculus,Rattus norvegicus,Cricetulus griseus,Homo sapiens,Bos taurus)
• Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling (, NA)
• Chemoprevention of Head and Neck Squamous Cell Carcinoma through Inhibition of NFKB Signaling (, NA)
• Emerging role of Interleukin-22 in autoimmune diseases (, NA)
• GSK3B and the control of infectious bacterial diseases (, Staphylococcus aureus,Mycobacterium tuberculosis,Pseudomonas aeruginosa,Helicobacter pylori,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Streptococcus pneumoniae,Salmonella enterica,Porphyromonas gingivalis,Bacillus anthracis,Chlamydia trachomatis,Neisseria meningitidis,Francisella tularensis,Streptomyces hygroscopicus,Streptococcus sp. group A,Streptococcus sp. group B,Yersinia enterocolitica,Streptomyces albus,Moraxella catarrhalis,Streptomyces verticillus,Mus musculus,Rattus norvegicus,Nicotiana tabacum,Curcuma longa,Homo sapiens,Mouse mammary tumor virus)
• New Insights into Hypertension-Associated Erectile Dysfunction (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES (, NA)
• DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES (, NA)
• DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES (, NA)
• DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES (, NA)
• DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES (, NA)
• DIETARY HYPERGLYCEMIA, GLYCEMIC INDEX AND METABOLIC RETINAL DISEASES (, NA)
• Beta2-adrenergic receptor engagement on a B cell that will make IgE uses a unique signaling pathway to increase the level of IgE produced (, NA)
• Beta2-adrenergic receptor and CD86 signaling pathways converge to induce an increase in the level of IgG1 produced by an activated B cell (, NA)
• Regulation of ABCA1 Functions by Signaling Pathways (, Homo sapiens,Mus musculus)
• Targeting angiogenesis for the treatment of prostate cancer (, NA)
• Signaling networks for brain, lung, and bone metastases of breast cancer (, NA)
• Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease (, NA)
• Molecular Pathways: Co-Expression of Immune Checkpoint Molecules: Signaling Pathways and Implications for Cancer Immunotherapy (, Homo sapiens,Mus musculus,Plasmodium yoelii,NA,NA)
• MULTIPLE WAYS TO DIE: DELINEATION OF THE UNFOLDED PROTEIN RESPONSE AND APOPTOSIS INDUCED BY SURFACTANT PROTEIN C BRICHOS MUTANTS (, NA)
• DNA Damage Response, Redox Status and Hematopoiesis (, Homo sapiens,Mus musculus,Human papillomavirus type 16,Calloplesiops altivelis)
• Diabetic Neuropathy: Mechanisms to Management (, NA)
• AUTOPHAGY IN BRAIN TUMORS: A NEW TARGET FOR THERAPEUTIC INTERVENTION (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae)
• Class III Histone Deacetylase Sirtuin 1 in Immune Suppression and Its Therapeutic Potential in Rheumatoid Arthritis (, NA)
• Src REGULATES SPHINGOSINE-1-PHOSPHATE MEDIATED SMOOTH MUSCLE CELL MIGRATION (, Oryctolagus cuniculus,Capra hircus,Homo sapiens,Mus musculus,Adenoviridae)
• Intercellular communication between adjacent epithelial cells via cell–cell signaling receptors (, NA)
• Unraveling intestinal stem cell behavior with models of crypt dynamics (, Homo sapiens,Mus musculus)
• HER 2: Biology, Detection, and Clinical Implications (, NA)
• The mechanism of late PC (, NA)
• Protective effects and mechanisms of sirtuins in the nervous system (, Homo sapiens,Saimiri sciureus,Saimiri,Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,prion,Ginkgo biloba,mixed culture,Bos taurus,Danio rerio,Adenoviridae)
• TOR in the immune system (, Human immunodeficiency virus 1,unidentified influenza virus,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Mycobacterium tuberculosis)
• Sarcolemmal actin assembly and nuclear signaling (, NA)
• Beta-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas (, NA)
• Molecular Pathways: BRAF Induces Bioenergetic Adaptation by Attenuating Oxidative Phosphorylation (, NA)
• microRNAs in cancer (, NA)
• Cap-dependent and elongation translational control by GNRH (, NA)
• Calcineurin Signaling Regulates Neural Induction Through Antagonizing the BMP Pathway (, NA)
• How to understand and outwit adaptation (, Saccharomyces cerevisiae,Allium tricoccum,Guibourtia demeusei,Homo sapiens,Mus musculus,Escherichia coli,Dictyostelium discoideum)
• Bayesian Brain Immune and Microglia Module (, Homo sapiens,Mus musculus)
• Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry (, NA)
• MiRNA Regulation of the Human Glycome (, NA)
• Pro-inflammatory Cytokine/Chemokine Production and Breast Tumor Invasion (, NA)
• Molecular mechanisms of FGFR3 signaling in cartilage (, NA)
• Glycosylated Synaptomatrix Regulation of Trans-Synaptic Signaling (, Armoracia rusticana,Nicotiana tabacum,Triticum aestivum,Arachis hypogaea,Raphanus sativus,Ricinus communis,Datura stramonium,Ulex europaeus,Griffonia simplicifolia,Aleuria aurantia,Vigna unguiculata subsp. cylindrica,Vicia villosa,Maackia amurensis,Drosophila melanogaster,Caenorhabditis elegans,Hippospongia communis,Limulus polyphemus,Limacus flavus,Mus musculus,Rattus norvegicus,Bos taurus,Equus caballus,Cricetulus griseus,Cervus elaphus,Danio rerio,Coturnix coturnix,Homo sapiens)
• Ciliary-vesicle-dependent steps of ciliogenesis, and modular organization and mechanism of the IFT machinery (, NA)
• Model depicting ciliary cargo trafficking pathways (, NA)
• O-glycan biosynthesis/human version pathway (, Homo sapiens,Mus musculus,Bos taurus,Xenopus laevis,unidentified influenza virus)
• The IRS-1→PI3K→Akt insulin signaling pathway (, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa)
• Schematic summary of hippocampal formation alterations in the IR→IRS-1→PI3K→Akt→mTOR signaling pathway of AD dementia cases versus age- and gender-matched controls (, Mus musculus,Rattus norvegicus,Homo sapiens,Curcuma longa)
• Schematic diagram shows the possible effect of xanthones on the apoptosis pathways (, NA)
• Metabolic pathways, transport, and receptors of S1P (, Mus musculus,Rattus norvegicus,Homo sapiens,Bos taurus,Danio rerio,Corynebacterium phage gamma,Isaria sinclairii)
• GAq - Ca2+ signaling pathway promotes actin-mediated epidermal wound closure (, Escherichia coli,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Xenopus laevis,Escherichia coli OP50,Homo sapiens,Mus musculus,Colletotrichum paranaense)
• Pathways leading from ssDNA-bound RPA to the recruitment of an error-prone polymerase η, ι, K or Rev1 for bypass of a potential template lesion (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Homo sapiens,Mus musculus,Venustaconcha ellipsiformis)
• Dietary Fatty Acids and the Aging Brain (, NA)
• Omega-3 fatty acids and dementia (, NA)
• Protein Kinase Signaling at the Crossroads of Myocyte Life and Death in Ischemic Heart Disease (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Solanum tuberosum,Homo sapiens,NA)
• Integrated Analysis of Genome-wide Copy Number Alterations and Gene Expression in MSS, CIMP-negative Colon Cancer (, Homo sapiens,Mus musculus,Bikinia letestui)
• Noncanonical transforming growth factor B signaling in scleroderma fibrosis (, NA)
• Apigenin Modulates Insulin-like Growth Factor Axis: Implications for Prevention and Therapy of Prostate Cancer (, NA)
• Targeting glioma stem cells: a novel framework for brain tumors (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Genes involved in the TGF beta signaling pathway after 5 days (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Ras-induced Senescence and its Physiological Relevance in Cancer (, Homo sapiens,Mus musculus)
• Neural tube defects – recent advances, unsolved questions and controversies (, Mus musculus,Rattus norvegicus,Gallus gallus,Danio rerio,Homo sapiens,Triticum aestivum,Felis catus)
• TGFB family signaling for Müllerian duct regression (, Mus musculus,Amniota,Homo sapiens)
• Clopidogrel activation and platelet aggregation pathways (, Homo sapiens)
• Bacterial effectors that target and manipulate the innate immune and inflammatory pathways (, NA)
• NFKB gene signature predicts prostate cancer progression (, NA)
• The ERK1/2 MAPK signaling network controlled by receptor tyrosine kinases and Ras (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Phosphorylation of the activation loop serines on MEK1 and 2 decreases affinity for allosteric inhibitors such as trametinib and selumetinib (, Homo sapiens,Mus musculus,Diaporthe sclerotioides)
• Roles of TGFB in the tumour microenvironment (, Mus musculus,Rattus norvegicus,Homo sapiens)
• Mechanism of white matter damage in SHR-SP (, NA)
• Network-Based Kernel Machine Test for the Identification of Risk Pathways in Genome-Wide Association Studies (, NA)
• Importance of Breast Cancer Subtype in the Development of Androgen Receptor Directed Therapy (, NA)
• Tumor Suppressor p53 and Estrogen Receptors in Nuclear–Mitochondrial Communication (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus,Mouse mammary tumor virus,NA,NA)
• Hereditary Hemochromatosis and Transferrin Receptor 2 (, NA)
• Hepatic S-adenosylmethionine (SAMe) metabolism (, Mus musculus,Rattus norvegicus,Homo sapiens)
• TGFB signalling in context (, Drosophila melanogaster,Trichoplax adhaerens,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Gallus gallus)
• Conservation of host cells and pathogen categories in zebrafish and mammalian infection by eukaryotes (, Homo sapiens,Danio rerio)
• JAK-STAT signaling in adipose tissue function (, NA)
• Complement system (, Mus musculus,Rattus norvegicus,Homo sapiens,Sus scrofa,Lareunionomyces loeiensis,Sugarcane Ramu stunt disease phytoplasma)
• Molecular and biophysical characterization of the human blood-nerve barrier: Current concepts (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Avena sativa,Ulex europaeus,Homo sapiens,Betapolyomavirus macacae)
• Signaling pathways modulated by PKD1 in cancer (, NA)
• HIV induction by PKC activators and HDAC and BET inhibitors: NFKB is sequestered in the cytoplasm by IKB (, NA)
• Signal transduction by prostaglandin receptor EP2 (, NA)
• Wnt signaling pathway (, Saccharomyces cerevisiae,Lareunionomyces loeiensis,Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• KIBRA in Hippo pathway (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Nicotiana tabacum,Citrus medica,Mus spretus,Homo sapiens,Chlorocebus aethiops,Drosophila melanogaster,Canis lupus familiaris,Dipnomorpha)
• G protein-coupled receptors (GPCR) trigger dissociation of GA and GBG heterotrimeric G proteins upon agonist stimulation (, NA)
• PA can be generated de novo,, by sequential enzyme-catalyzed acylations of glycerol-3-phosphate, or in response to cell signaling pathways () (, NA)
• Inferred signaling network (, Homo sapiens)
• Pathway adapted from by including three missed edges and correcting one reversed edge (, Homo sapiens)
• DEVELOMENT AND NEUROGENIC POTENTIAL OF MÜLLER GLIAL CELLS IN THE VERTEBRATE RETINA (, Gallus gallus,Danio rerio,Xenopus laevis,Carassius auratus,Lithobates pipiens,Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Cricetus cricetus,Felis catus,Setonix brachyurus,Drosophila melanogaster,Apis mellifera,Homo sapiens,Sequoia sempervirens)
• Mitochondrial and metabolic checkpoints of T-cell activation and apoptosis signals (, NA)
• Chromatin modifications as therapeutic targets in MLL-rearranged Leukemia (, NA)
• MAPK pathway signaling in malignant melanoma leads to phosphorylation and activation of RAS, RAF, MEK, and ERK, a process that ultimately regulates the cell cycle, differentiation, and apoptosis (, Homo sapiens,Mus musculus,Diaporthe sclerotioides,Myxoma virus)
• Schematic shows two possible signaling pathways that can be triggered by nerve growth factor (NGF) binding (, NA)
• Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP (, NA)
• EPEC1 and EHEC use different mechanisms of Tir activated signaling cascades that converge on common host actin nucleation factors, N-WASP and Arp2/3 to form actin pedestals (, Escherichia coli,Homo sapiens)
• IFNAB and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions (, NA)
• Identification and development of mPGES-1 inhibitors: where we are at? (, NA)
• Immune evasion strategies of Porphyromonas gingivalis (, Porphyromonas gingivalis,Homo sapiens)
• Targeting protein prenylation for cancer therapy (, Homo sapiens)
• MicroRNA regulation of the germinal center response (, Homo sapiens,Mus musculus)
• Trafficking of endosomal Toll-like receptors (, NA)
• Developmental pathways in Saccharomyces cerevisiae (, Saccharomyces cerevisiae,Homo sapiens)
• Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27 (, NA)
• JAK/STAT pathway dysregulation in tumors: A Drosophila perspective (, NA)
• An Inside View: VEGF Receptor Trafficking and Signaling (, NA)
• Mucins in the Pathogenesis of Breast Cancer: Implications in Diagnosis, Prognosis and Therapy (, NA)
• NK cells: immune cross-talk and therapeutic implications (, NA)
• Nitric Oxide and Arginine Dysregulation: A Novel Pathway to Pulmonary Hypertension in Hemolytic Disorders (, Homo sapiens,Mus musculus,Ovis aries)
• Bid can be activated by multiple proteases in response to a variety of pathophysiological signals (, Homo sapiens,Mus musculus,Ovis aries)
• Purinergic autoregulation model of mechanosensitivity in human ECs (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Bos taurus)
• Signaling pathway initiated by Edn1-induced Ednra signaling (, NA)
• Complement activation and effector functions (, NA)
• FGF signaling in neural specification of hESCs (, NA)
• Protein phosphatases in pancreatic islets (, Coxsackievirus,Rous sarcoma virus,Avian sarcoma virus,Mus musculus,Rattus norvegicus,Homo sapiens,Equus caballus,Meleagris gallopavo,Neurospora crassa,NA)
• Progesterone and breast cancer (, NA)
• Chromatin Landscape and Transcription Factors in T-Cell Programming (, Homo sapiens,Mus musculus)
• Apoptotic cell clearance: basic biology and therapeutic potential (, Escherichia coli,Staphylococcus aureus,Shigella flexneri,Chlamydia pneumoniae,Homo sapiens,Mus musculus,Nicotiana tabacum,Equus caballus)
• Subversion of the actin cytoskeleton during viral infection (, Rous sarcoma virus,Human immunodeficiency virus 1,Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human immunodeficiency virus,Human papillomavirus,unidentified influenza virus,Mouse mammary tumor virus,Respiratory syncytial virus,Human papillomavirus type 16,Human gammaherpesvirus 8,Vesicular stomatitis virus,Vaccinia virus,Enterovirus C,Measles morbillivirus,Betapolyomavirus macacae,Coxsackievirus,Ebola virus sp.,Polyomavirus sp.,Human orthopneumovirus,Murine leukemia virus,Suid alphaherpesvirus 1,African swine fever virus,Human respirovirus 3,Avian leukosis virus,Human adenovirus 2,Avian retrovirus,human papillomavirus 31,Equine infectious anemia virus,Simian sarcoma-associated virus,Frog virus 3,Yaba-like disease virus,Lymphocystis disease virus 1,Mus musculus,Rattus norvegicus,Cricetus cricetus,Gallus gallus,Calloplesiops altivelis,Homo sapiens,Equus caballus,NA,NA,NA,NA)
• SIRT1 in neurodevelopment and brain senescence (, Mus musculus,Rattus norvegicus,Saccharomyces cerevisiae,Drosophila melanogaster,Caenorhabditis elegans,Diaporthe sclerotioides,Homo sapiens,prion)
• From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling (, NA)
• From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling (, NA)
• Several types of TG2-containing adhesive / signaling complexes present on the cell surface (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• Normal activation of MAPK pathway and pathway response to RAF inhibition (, NA)
• Signaling pathways mediating DON-induced RSR, including the MAPK (A, blue), NFKB (B, red), AKT and AMPK pathways (C, green) (, Homo sapiens,Mus musculus,Arabidopsis thaliana)
• Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis (, NA)
• Differential Expression of MicroRNA and Predicted Targets in Pulmonary Sarcoidosis (, NA)
• Transcriptional control of spermatogonial maintenance and differentiation (, NA)
• Testosterone signaling pathways in Sertoli cells (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens)
• MUC1: A Novel Metabolic Master Regulator (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,Pseudomonas aeruginosa)
• MUC1: A Novel Metabolic Master Regulator (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,Pseudomonas aeruginosa)
• MUC1: A Novel Metabolic Master Regulator (, Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Caenorhabditis elegans,Pseudomonas aeruginosa)
• Genomic and nongenomic vascular effects of estrogen (, Homo sapiens,Equus caballus)
• MicroRNAs in pancreatic cancer metabolism (, Mus musculus,Rattus norvegicus,Homo sapiens,Danio rerio,clinical samples)
• Differential Transcription of Fathead Minnow Immune-related Genes Following Infection with Frog virus 3, an Emerging Pathogen of Ectothermic Vertebrates (, NA)
• Angiogenesis Inhibitors (VSP Inhibitors) being tested in human cancer trials (, NA)
• PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis (, NA)
• Cellular functions of proteins commonly mutated in uveal melanoma (, Homo sapiens)
• ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway (, NA)
• Pathways for sulfide biogenesis and clearance (, NA)
• HEPCIDIN AND IRON HOMEOSTASIS (, Mus musculus,Rattus norvegicus,Meriones unguiculatus,Caenorhabditis elegans,Asterias forbesi,Homo sapiens,Arabidopsis thaliana,Turdus migratorius)
• Developmental Control of Size in Insects (, Drosophila melanogaster,Manduca sexta,Homo sapiens)
• Redox control of p53 in the transcriptional regulation of TGFB1 target genes through SMAD cooperativity (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Mustela lutreola,Mus musculus,Rattus norvegicus,Homo sapiens,Xenopus laevis)
• Brief Overview of DNA Damage Repair: Three common types of DNA damage are depicted in this image as well as an summary of the pathways/proteins that are activated in response to each type of damage (, Hepatitis B virus,Human gammaherpesvirus 4,Human alphaherpesvirus 1,Human papillomavirus,Human papillomavirus type 16,Human betaherpesvirus 5,Adeno-associated virus,Human gammaherpesvirus 8,Betapolyomavirus macacae,Polyomavirus sp.,Human papillomavirus types,human papillomavirus 18,Alphapapillomavirus 7,human papillomavirus 11,JC polyomavirus,Deltapapillomavirus 4,human papillomavirus 31,Human papillomavirus type 8,Human betapapillomavirus,Homo sapiens,Mus musculus,Calloplesiops altivelis,Pinellia pedatisecta,NA)
• Notch: Architect, Landscaper, and Guardian of the Intestine (, NA)
• Ingenuity Pathway Analyses: Details are as in (, NA)
• Targeting JAK2 in the therapy of myeloproliferative neoplasms (, Mus musculus,Rattus norvegicus,Homo sapiens,NA)
• Role of the CD40–CD40L pathway during the CD8 primary response (, Toxoplasma gondii,Leishmania donovani,Patella vulgata,Hepatitis B virus,Human immunodeficiency virus,Homo sapiens,Mus musculus,NA,NA,NA)
• The CD40-CD40L pathway plays a critical role in CD4 T-cell–mediated IL-21 production during the rescue of exhausted T-cell response (, Toxoplasma gondii,Leishmania donovani,Patella vulgata,Hepatitis B virus,Human immunodeficiency virus,Homo sapiens,Mus musculus,NA,NA,NA)
• Regulation of Inflammation in Cancer by Eicosanoids (, Mus musculus,Rattus norvegicus,Homo sapiens,Human gammaherpesvirus 8)
• DNA double-strand break repair pathway choice and cancer (, Gallus gallus,Xenopus laevis,Dipturus trachyderma,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,Caenorhabditis elegans)
• The Wnt/Beta-catenin signaling pathway that responds to Norrin interaction with Frizzled4 (, Homo sapiens,Mus musculus,Drosophila melanogaster,Xenopus laevis)
• Therapeutics in development that target survival pathways activated by LMP1 and LMP2a (, NA)
• WT1/EGR1-mediated Control of STIM1 Expression and Function in Cancer Cells (, NA)
• D-PDMP inhibits ox-LDL induced LCS activity and atherosclerosis development (, NA)
• Deciphering the role of Th17 cells in human disease (, NA)
• Tonic regulation of vascular permeability (, NA)
• HRG-mediated signaling via mTORC2 to mTORC1 (, Homo sapiens,Mus musculus,Armoracia rusticana)
• Core phosphatases of the PI 3-Kinase pathway (, NA)
• Induction of EMT and breast cancer progression through aberrant activation of Aurora-A kinase activity (, Homo sapiens,Mus musculus)
• Polarity proteins and actin regulatory proteins are unlikely partners that regulate cell adhesion in the seminiferous epithelium during spermatogenesis (, NA)
• Signaling pathways that positively regulate ecdysteroidogenesis in the PG in Drosophila melanogaster (, Drosophila melanogaster,Homo sapiens)
• Genetic Basis of Diffuse Large B Cell Lymphoma (, NA)
• Contribution of chemoattractant GPCRs to glioma stem-like cell mediated tumorigenesis, invasion and angiogenesis express various GPCRs (, NA)
• Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease (, NA)
• Signalling pathways activated by chemokine receptors (, NA)
• Regulation of Akt phosphorylation (, NA)
• Components of the two mTOR complexes (, NA)
• Proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease (, Homo sapiens,Macaca mulatta,Papio hamadryas,Mus musculus,Rattus norvegicus,Bos taurus,Diaporthe sclerotioides)
• Phosphoglycerate mutase 1 (PGAM1) controls the levels of allosteric regulators 3-phosphoglycerate and 2-phosphoglycerate (, NA)
• Pathway Studio® (Ariadne Genomics) was used to identify known relationships among human homologues of the genes identified as differentially regulated by ANOVA (, NA)
• Working model describing how in HIV+ macrophages constitutively activated PI3K elicits blunting of lipid A-induced increases in TNFA release through sustained mTOR activation (, NA)
• Drosophila melanogaster as a model system for human brain cancers (, Drosophila melanogaster,Homo sapiens)
• Protease Regulation: The Yin and Yang of neural development and disease (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Gallus gallus,Ambystoma mexicanum,Homo sapiens,Canis lupus familiaris)
• Scheme of participation of MC1R in regulation of melanogenesis (, NA)
• Scheme of the impact of MC1R on development of melanoma (, NA)
• Origins and removal of ribonucleotides in DNA (, NA)
• Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1 (, NA)
• IL-15: a central regulator of celiac disease immunopathology (, NA)
• Current understanding of molecular mechanisms regulating spermatogonial stem cell (SSC) self-renewal in mice (, Homo sapiens,Mus musculus)
• Important mechanotransduction signaling pathways in striated muscle cells (, NA)
• Simplified diagram of the TLR-mediated and interferon (IFN)-mediated immunity in response to viruses (, NA)
• Design and application of oncolytic HSV vectors for glioblastoma therapy (, NA)
• Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets? (, NA)
• Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis (, Porphyromonas gingivalis,Homo sapiens)
• Cilia and cilia-associated proteins in cancer (, Homo sapiens,Mus musculus,Danio rerio,Lareunionomyces loeiensis,Corynebacterium phage gamma)
• Bile Acids are Nutrient Signaling Hormones (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Clostridium scindens)
• Proposed model for the formation of reactive oxygen species at mitochondria, activation of Nrf2, and regulation of phase 2 gene expression in the nucleus (, Equus caballus,Homo sapiens)
• Comparison of apoptotic pathways and NLRP3 inflammasome activation (, NA)
• Cell Death Pathways (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• Regulation of mTORC1 by amino acids (, NA)
• Regulation of receptor-mediated endocytosis by CRL pathways (, Saccharomyces cerevisiae,Arabidopsis thaliana,Human immunodeficiency virus 1,Influenza A virus,Vesicular stomatitis virus,Komagataella pastoris,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Xenopus laevis,Pseudomonas aeruginosa,Mustela lutreola,NA)
• Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology (, NA)
• Signal Transduction in Vasculogenesis and Developmental Angiogenesis (, Mus musculus,Danio rerio,Cavia porcellus,Coturnix coturnix,Homo sapiens,Paraechinus aethiopicus,Corynebacterium phage gamma)
• Insulin/mTOR signaling pathway and also the extrinsic modifiers that are present in diabetes (, NA)
• Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factorB signalling (, NA)
• Cell-type specific crosstalk between p38 MAPK and Rho signaling in lung micro- and macrovascular barrier dysfunction induced by Staphylococcus aureus-derived pathogens (, NA)
• Muscle hypertrophy and atrophy (, Mus musculus,Rattus norvegicus,Cavia porcellus,Homo sapiens,Candida dubliniensis)
• Sulfoglucuronosyl paragloboside promotes endothelial cell apoptosis in inflammation: Elucidation of a novel glycosphingolipid-signaling pathway (, Mus musculus,Rattus norvegicus,Bos taurus,Oryctolagus cuniculus,Homo sapiens,Campylobacter jejuni)
• Examples of pathway engineering and combinatorial biosynthesis to generate new analogs: A (, Escherichia coli,Streptomyces coelicolor,Streptomyces hygroscopicus,Streptomyces lividans,Streptomyces griseus,Streptomyces avermitilis,Streptomyces albus,Saccharopolyspora erythraea,Streptomyces microflavus,Streptomyces fradiae,Streptomyces peucetius,Salinispora tropica,Streptantibioticus cattleyicolor,Streptomyces argillaceus,Streptomyces filamentosus,Streptomyces platensis,Streptomyces lincolnensis,Streptomyces rapamycinicus,Streptomyces sp. BY,Streptomyces lasalocidi,Saccharomyces cerevisiae,Glycine max,Embryophyta,Aspergillus nidulans,Catharanthus roseus,Aspergillus oryzae,Aspergillus terreus,Penicillium chrysogenum,Vinca minor,Monascus purpureus,Rhodotorula mucilaginosa,Penicillium griseofulvum,Glycyrrhiza echinata,Aspergillus sp. ATCC 58397,Homo sapiens,Mus musculus,Bos taurus,NA)
• Insulin Resistance, Hyperglycemia, and Atherosclerosis (, Mus musculus,Rattus norvegicus,Homo sapiens,Candida dubliniensis,NA)
• Signaling components of the RAS/MAPK pathway found to harbor activating mutations in various types of nevi and melanoma (, NA)
• Targeting the PI3K/AKT/mTOR pathway (, Homo sapiens,Mus musculus)
• Targeting B-cell activation (, Homo sapiens,Mus musculus)
• Overview of the general innate immune response to viral infection (, NA)
• Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors (, Homo sapiens)
• Proposed estrogen receptor (ER)-activated signaling pathways involved in vasodilation (, Bos taurus,Oryctolagus cuniculus,Canis lupus familiaris,Sus scrofa,Equus caballus,Mus musculus,Rattus norvegicus,Homo sapiens,Glyptocephalus cynoglossus)
• mTORC2 in the center of cancer metabolic reprogramming (, Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,clinical samples)
• Interaction of kisspeptin, estrogen and BMP-4 in regulation of GnRH production by GT1-7 cells (, NA)
• Molecular Pathways: Niches in Metastatic Dormancy (, Homo sapiens,Mus musculus,NA)
• MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY (, Mus musculus,Rattus norvegicus,Homo sapiens,Cordeauxia edulis,NA)
• MOLECULAR MECHANISMS OF FEAR LEARNING AND MEMORY (, Mus musculus,Rattus norvegicus,Homo sapiens,Cordeauxia edulis,NA)
• Complement regulation of T cell immunity (, Homo sapiens,Mus musculus,Lareunionomyces loeiensis)
• Turning Off AKT: PHLPP as a Drug Target (, Drosophila melanogaster,Caenorhabditis elegans,Bilateria,Mus musculus,Rattus norvegicus,Homo sapiens,Saccharomyces cerevisiae,Euteleostomi)
• Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease (, Homo sapiens,Mus musculus)
• Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease (, NA)
• Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes (, Mus musculus,Rattus norvegicus,Homo sapiens,Oryctolagus cuniculus)
• All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis (, Homo sapiens,Mus musculus,Oryctolagus cuniculus,Arachis hypogaea,Betapolyomavirus macacae)
• Type I Interferon in the Pathogenesis of Lupus (, Homo sapiens,Mus musculus)
• Pathogenic microbes and community service through manipulation of innate immunity (, NA)
• Wnt signaling is required for long-term memory formation (, Matthiola incana,Agaricus bisporus,Brassica napus subsp. rapifera,Mus musculus,Drosophila melanogaster,Homo sapiens)
• Unexpected targets and triggers of autoimmunity (, Candida albicans,Candida albicans 23R,Homo sapiens,Mus musculus,Staphylococcus aureus,gut metagenome)
• Signaling networks control chemotaxis (, NA)
• Shh and BMP signaling (, Mus musculus,Rattus norvegicus,Gallus gallus,Coturnix coturnix,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Wnt signaling pathway (, Mus musculus,Rattus norvegicus,Gallus gallus,Coturnix coturnix,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• The sonic hedgehog signaling pathway in the primary cilium (, Mus musculus,Rattus norvegicus,Gallus gallus,Coturnix coturnix,Homo sapiens,Drosophila melanogaster,Lareunionomyces loeiensis)
• Beta-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis (, NA)
• Diagram showing the effects of knockout or blockade of specific elements of the alternative, classical and lectin pathways of complement activation on the pathogenesis of anti-MPO induced murine crescentic glomerulonephritis (, Homo sapiens,Mus musculus)
• Non-homologous end joining: emerging themes and unanswered questions (, NA)
• Recruiting Adaptive Cellular Stress Responses for Successful Brain Aging (, NA)
• Ingenuity pathway analysis of phosphatidylinositol 3-kinase (PI3K) signaling pathway affected by angiotensin II (, Mouse mammary tumor virus,Betapolyomavirus macacae,Homo sapiens,Mus musculus,Canis lupus familiaris,Xenopus laevis,Sequoia sempervirens)
• Regulation of type I interferon responses (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Mycobacterium leprae,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA,NA)
• Regulation of type I interferon responses (, Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhimurium,Listeria monocytogenes,Mycobacterium leprae,Homo sapiens,Mus musculus,Saccharomyces cerevisiae,NA,NA)
• Contextualizing Sharpin within the NFKB pathway by comparative analysis of mutant transcriptomes (, Human immunodeficiency virus 1,Influenza A virus,unidentified influenza virus,Respiratory syncytial virus,H1N1 subtype,Vesicular stomatitis virus,H5N1 subtype,Variola virus,H7N9 subtype,Influenza A virus H3N2,Modified Vaccinia Ankara virus,Mycobacterium tuberculosis,Salmonella enterica subsp. enterica serovar Typhi,Francisella tularensis subsp. tularensis,Sus scrofa,Mustela putorius furo,Homo sapiens,Mus musculus,Lareunionomyces loeiensis,clinical samples,Pandion haliaetus)
• Irinotecan Pathway, view of a model human liver cell showing blood, bile, and intestinal compartments, indicating tissue-specific involvement of genes in the irinotecan pathway (, Homo sapiens)
• HDAC-Dependent Transcriptional Repression of Bmp-7 Potentiates TGF-Beta-Mediated Renal Fibrosis in Obstructive Uropathies (, Homo sapiens,Mus musculus,Oryctolagus cuniculus)
• Regulation of Primary Response Genes (, NA)
• Immunoproteasomes Regulate Lps-Induced Trif/Tram Signaling Pathway in Murine Macrophages (, Escherichia coli,Cereibacter sphaeroides,Escherichia coli PA28,Mus musculus,Bos taurus,unidentified influenza virus,Homo sapiens)
• Mammary Cell Proliferation Network (, Homo sapiens,Saccharomyces cerevisiae)
• Rapid tip growth: Insights from pollen tubes (, NA)
• Schematic models of signalling pathways used by SDF-1/CXCR4 and GLP-1/GLP-1R in the activation of beta catenin/TCF7L2-mediated transcriptional expression of genes involved in beta cell survival and proliferation a SDF-1 activation of WNT signalling (, Mus musculus,Rattus norvegicus,Homo sapiens,Mouse mammary tumor virus)
• Three commonly differentially expression MicroRNAs in pancreatic cancer tissue and patient blood: MicroRNAs 21, 155, and 200 (, Homo sapiens)
• Predicted network linking pancreatic cancer miRNA markers, known pancreatic cancer genetic lesions, and DAMPs (, Homo sapiens)
• NKT-cell subsets: Promoters and protectors in inflammatory liver disease (, NA)
• Phosphoinositide-3-kinase-Akt-mTOR pathway (, Homo sapiens,Mus musculus)
• Redox biology of the intestine (, NA)
• NFKB signaling pathway (, NA)
• Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells (, Mus musculus,Rattus norvegicus,Oryctolagus cuniculus,Capra hircus,Homo sapiens,Drosophila melanogaster,Corynebacterium phage gamma)
• Phosphorylation of Foxo1 at S253 by Akt promotes Foxo1 cytoplasmic retention and ubiquitination, which serves as a central mechanism controlling Foxo1 stability and activity () (, NA)
• FGF receptors signal through the evolutionarily conserved SHP2/RAS/ERK pathway to mediate biological responses (, NA)
• Ablation of p21-Activated Kinase-1 in Mice Promotes Isoproterenol-Induced Cardiac Hypertrophy in Association with Activation of Erk1/2 and Inhibition of Protein Phosphatase 2A (, NA)
• Toward the development of podocyte-specific drugs (, Mus musculus,Rattus norvegicus,Drosophila melanogaster,Caenorhabditis elegans,Homo sapiens,Danio rerio)
• Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/Beta-catenin/cyclin D1 signaling pathway in rats (, Mus musculus,Rattus norvegicus,Triticum aestivum,Camellia sinensis,Homo sapiens)
• Epidermal growth factor receptor (EGFR) pathway activation during HNSCC carcinogenic process (, Mus musculus,Cricetus cricetus,Homo sapiens,Nicotiana tabacum)
• Pathogenesis of T2D: adipose tissue, the pancreas, NLRP3 and T2D (, NA)
• EGFR/PI3K Pathway (, Homo sapiens)
• Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain (, Saccharomyces cerevisiae,Diaporthe sclerotioides,Triticum aestivum,Boswellia sacra,Saccharomyces cerevisiae VL3,Mus musculus,Rattus norvegicus,Homo sapiens,Caenorhabditis elegans,Capra hircus,Mouse mammary tumor virus)
• G-Protein Coupled Receptors Engage the Mammalian Hippo pathway through F-Actin (, NA)
• Graphic illustration of the perturbation of the insulin signal transduction pathways by cellular stressors (, NA)
• Autophagy modulation as a potential therapeutic target for diverse diseases (, NA)
• Autophagy modulation as a potential therapeutic target for diverse diseases (, NA)
• Targets and structure of compstatin (, Homo sapiens,Macaca mulatta,Macaca fascicularis,Papio hamadryas,Escherichia coli IS5,Escherichia coli KD1,Diaporthe sclerotioides)
• Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease (, Homo sapiens,Macaca mulatta,Saimiri sciureus,Saimiri,Mus musculus,Rattus norvegicus,Solanum tuberosum,Alocasia macrorrhizos)
• Wnt Signal Transduction Pathways (, Gallus gallus,Danio rerio,Xenopus laevis,Oryzias latipes,Phoenicopterus roseus,Mus musculus,Rattus norvegicus,Cricetus cricetus,Homo sapiens,Drosophila melanogaster)
• Interplay between Wnt/Beta-catenin signaling and HIV: Virologic and biologic consequences in the CNS (, NA)
• Rescue of the aged fibroblast to myofibroblast differentiation by amplification of TGFB signaling via the Tak1/AMPK/p38MAPK pathway (, NA)
• Hepatitis C, Porphyria Cutanea Tarda, and Liver Iron: An Update (, NA)
• Simplified diagram illustrating the mTOR signaling pathway (, NA)
• Schematic model depicting how HMW isoforms regulate bone formation (, Bos taurus,Oryctolagus cuniculus,Capra hircus,Ovis aries,Equus asinus,Mus musculus,Rattus norvegicus,Homo sapiens)
• Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor (, NA)
• Regulation of embryonic stem cell self-renewal and pluripotency by leukaemia inhibitory factor (, NA)
• Simplified summary of the role of ATGL in macrophages.FFAs which are taken up by macrophages are incorporated into TGs (and cholesteryl esters) (, Homo sapiens,Mus musculus,Candida dubliniensis)
• Postulated interactions between 20-HETE and RAS in the vascular endothelium (, NA)
• Targeting the TGFB signalling pathway in disease (, NA)